101 results about "Cardiac valve prosthesis" patented technology

A delivery system for transcatheter implantation of a heart valve prosthesis. The delivery system includes an outer sheath component defining a lumen therethrough, an elongate tube having at least two flat wires longitudinally extending from a distal end thereof, and self-expanding first and second frames disposed in series within a distal portion of the outer sheath component and held in a compressed delivery configuration therein. The elongate tube and the at least two flat wires are slidably disposed within the lumen of the outer sheath component. In the compressed delivery configuration the at least two flat wires longitudinally extend along exterior portions of the first and second frames and are woven through adjacent ends of the first and second frames to releasably couple them to each other. Proximal retraction of the at least two flat wires from the first and second frames releases at least the first frame from the delivery system.

The application provides a heart valve prosthesis and a preparation method thereof, the heart valve prosthesis comprising a stent and an integrated valve, the integrated valve comprising artificial valve leaves and a skirt, and the integrated valve being fixed to the stent by sewing threads; the preparation method comprises the following steps: obtaining an integrated valve material, and sequentially subjecting the integrated valve material to cutting, pre-shaping and folding processes, and finally sewing the folded integrated valve material on the stent to obtain the heart valve prosthesis. The application can minimize the damage to the valve, increase the durability of the valve, simplify the sewing process, reduce the production cost and improve the production efficiency.

The present invention relates to a heart valve prosthesis for implantation into the heart of a patient and to an insertion system for introducing such a heart valve prosthesis into the heart of a patient.

A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

Heart valve prosthesis implantation apparatus (10), comprising: - a prosthesis catheter (11) with a heart valve prosthesis (12) to be implanted, - an ICE catheter (9) - for insertion into a surrounding area of ​​a heart valve (HC) to be treated, - for detecting a relative position (RPHC) and / or a relative orientation direction (ROHC) of the heart valve (HC) to the ICE catheter (9) by means of an ultrasound image (USHC) of the heart valve (HC) through the ICE catheter (9), and - preferably for performing ultrasound images (USPC) of the prosthesis catheter (11), wherein the ICE catheter (9) is configured to determine an absolute reference position (ARPHC) and / or an absolute reference orientation direction (AROHC) of the heart valve, 2D ultrasound images in multiple planes, and / or 3D ultrasound images of the heart valve (HK) to create- a navigation system (51) for determining an absolute position (APICE) and an absolute orientation direction (AOICE) of the ICE catheter (9), - a control device (52) for controlling the insertion of the heart valve prosthesis (12) into the annulus of the heart valve (HC) based on the ultrasound images (USHK, USPK, USHKP) of the ICE catheter (9) and position and orientation direction information (APICE, AOICE, APPK, AOPK, APHKP, AOHKP) from the navigation system (51), - a display (53) for simultaneously displaying information (APHKP, AOHKP) regarding the position and / or orientation of the heart valve prosthesis (12) and the 2D ultrasound images and / or 3D ultrasound images for monitoring the insertion of the heart valve prosthesis (12) into the annulus of the heart valve, wherein the control device (52) is set up toto verify the correct insertion of the heart valve prosthesis (12) based on a comparison of the current position (APHKP) and / or the current orientation direction (ORHKP) of the heart valve prosthesis (12) with the determined absolute reference position (ARPHK) and the reference orientation direction (AROHK) of the heart valve (HC).

The present invention relates to an atrioventricular heart valve prosthesis implantable, for example, into the heart of a mammal. The heart valve prosthesis comprises a collapsible-expandable tubular stent having a lumen, preferably having an opening cross-section or area during use or in a fully expanded state of the stent that is smaller than an opening area of a native atrioventricular heart valve to be replaced by the heart valve prosthesis. The heart valve prosthesis further includes an inner valve tip disposed within the lumen of the tubular stent that closes the heart valve by resting against each other, an outer valve leaflet that closes against the native valve leaflet, and at least one anchor wire connected directly or indirectly to the tubular stent. The invention also relates to a method for manufacturing a heart valve prosthesis and to a method for inserting a heart valve prosthesis.

Heart valve prostheses comprise an expandable stent frame configured to expand from a contracted orientation to an expanded orientation. The heart valve prostheses can further comprise a valve apparatus extending past a distal end of the expandable stent frame. The valve apparatus comprise a plurality of commissure posts, each commissure post of the plurality of commissure posts comprises a first end portion attached to a distal end portion of the expandable stent frame, a second end portion attached to a distal tip of the valve apparatus at a distal end of the valve apparatus. The plurality of commissure posts converge together in a distal direction towards the distal tip. The valve apparatus further comprise a plurality of leaflets each coupled to a corresponding pair of the plurality of commissure posts.

The disclosure relates to a heart valve prosthesis with a variable sealing function, a method for replacing a native heart valve with a heart valve replacement prosthesis with a variable sealing function and the use of a heart valve replacement prosthesis with a variable sealing function for treating a heart valve disorder.

The present application provides a heart valve prosthesis, which has a first end and a second end opposite in a first direction; the heart valve prosthesis comprises a first support body, a second support body and an artificial valve leaflet; the first support body has a first edge and a second edge opposite in a second direction, which is perpendicular to the first direction; the second support body comprises a first segment, which is located on one side of the first support body and has a non-linear configuration; the first segment intersects the first edge at a first intersection point and intersects the second edge at a second intersection point; the second support body is connected with the first support body and allows the first segment to rotate relative to the first support body around a line connecting the first intersection point and the second intersection point; the artificial valve leaflet is connected with the edge of the second support body located on the side close to the first end and the first segment; the heart valve prosthesis has a contracted state and an expanded state; when the heart valve prosthesis switches from the contracted state to the expanded state, the first segment rotates and drives the middle part of the first segment to move in the direction close to the first end, and the distance between the middle part of the first segment and the first support body increases; when the heart valve prosthesis is in the expanded state, the area of the cross section of the artificial valve prosthesis perpendicular to the first direction first increases and then decreases along the first direction. The heart valve prosthesis can replace the native atrioventricular valve and / or the native arterial valve and has a larger effective valve orifice area.

Heart valve prosthesis delivery devices and methods. The devices include a delivery catheter and stabilization catheter. The stabilization catheter has expandable anchoring segments to anchor the device at a cardiac site superior to the implantation site of the heart valve prosthesis. The stabilization catheter also has a tubular assembly that includes an outer tubular member and an inner tubular member translationally displaceable within the outer tubular member. The outer tubular member defines a longitudinally extending slit and the inner tubular member defines an aperture positionable within the longitudinally extending slot. The device includes a snare and the location of the distal end of the snare adjacent to the distal portion of the delivery catheter is adjustable via translational displacement of the inner tubular member relative to the outer tubular member.

A heart valve prosthesis is positioned within an index valve prosthesis. The heart valve prosthesis includes an annular frame extending along a valve axis between a first valve end and a second valve end. The annular frame includes a plurality of frame members and is adjustable between a radially-collapsed configuration and a radially-expanded configuration. The annular frame includes an engagement region extending circumferentially around the valve axis and includes at least one protrusion arm extending radially outwardly. At least one anchor is attached to the at least one protrusion arm and contacts at least one lacerated leaflet of the index valve prosthesis and moves the at least one lacerated leaflet to a position that does not obstruct a coronary artery. Methods of implanting a heart valve prosthesis are provided.

A replacement heart valve prosthesis can be delivered to or within an existing prosthesis through a valve-in-valve delivery procedure. The existing prosthesis can be a prosthetic heart valve or other device that is implanted at a target site, such as an aortic or mitral valve of the heart. The methods provided herein can allow a surgeon to position a replacement prosthesis within or adjacent to an existing prosthesis and permit the replacement prosthesis to expand into engagement against the existing prosthesis. Thereafter, the surgeon can adjust components of the replacement prosthesis, including the position of separate anchor and frame components in order to ensure accurate and secure placement of the replacement prosthesis at the target site.

The present invention relates to a heart valve prosthesis for implantation into the heart of a patient, and to a delivery system for introducing such heart valve prosthesis into the heart of a patient.

An interventional delivery device for a heart valve prosthesis, and a threading member (101) of the delivery device. The interventional delivery device for the heart valve prosthesis comprises: an outer tube (103); an inner tube (102) located in the outer tube (103); a threading member (101) provided on the inner tube (102), the threading member (101) being provided with a threading hole (114) and a positioning portion (111); a suture end positioning member (105), one end of the suture end positioning member (105) being detachably positioned in the positioning portion (111) of the threading member (101); and a traction member (106), one end of the traction member (106) passing through the threading hole (114) to be connected to a heart valve prosthesis (104) and to be connected to the suture end positioning member (105), and the other end of the traction member extending out of the outer tube (103). By means of such an arrangement, the relative position of the heart valve prosthesis (104) and the heart can be adjusted, thereby improving the implantation accuracy of the heart valve prosthesis (104).

The invention relates to a method for reducing biological heart valve prosthesis calcification by adopting a titanium-containing coating in combination with ultraviolet irradiation. The invention relates to a method for treating a biological heart valve prosthesis with a titanium-containing coating, in particular a glutaraldehyde-immobilized pericardium, comprising the following steps: a) treating a biological heart valve prosthesis with a titanium-containing coating; and b) irradiating the treated biological heart valve prosthesis with light having a wavelength of 100 to 450 nm. In this way, the biological heart valve prosthesis with the uniform surface can be manufactured through the hypothesized polymer, and therefore the biological heart valve prosthesis with the uniform surface can be manufactured through the hypothesized polymer. Calcification of such a TAVI valve is significantly reduced, the life of the TAVI valve is increased, which increases the time interval at which such a TAVI valve must be replaced over the years.

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and / or improved means for positioning the replacement heart valve. A heart valve prosthesis is provided with a stent and at least one locator. The locator has an adapted design for positioning within a cusp of the native aortic valve for implantation at the native heart valve site. Placement of the locators within the cusps preferably prevents movement from the native heart valve site post-implantation, including proximal movement of the prosthesis into the left ventricle.

The invention relates to the technical field of medical apparatuses and instruments, and provides an interventional heart valve prosthesis conveying device and a threading piece thereof.The interventional heart valve prosthesis conveying device comprises an outer tube; an inner tube in the outer tube; the threading piece is arranged on the inner pipe, a threading part and a positioning part are arranged on the threading piece, the threading piece is provided with a channel used for guiding the inner pipe to penetrate through, and the threading part comprises at least one pair of threading hole and wire return hole; one end of the thread end positioning piece is detachably positioned in the positioning part of the threading piece; one end of each traction piece penetrates through the threading hole to be connected with the heart valve prosthesis and penetrates out of the thread return hole to be connected with the thread end positioning piece, and the other end of each traction piece extends out of the outer tube. According to the technical scheme, one traction piece can be separated in the threading process and the back-threading process through the threading hole and the wire returning hole which are in a pair, so that the situation that the traction piece interferes in the wire inlet process and the wire outlet process is reduced, and the operation convenience of medical staff is improved.

A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

A heart valve prosthesis for replacing a native atrioventricular valve of the heart. The prosthesis includes a housing component that is configured to be radially expandable and compressible between a radially compressed state and a radially expanded state to engage structure of the native atrioventricular valve to fix the housing component relative to the native atrioventricular valve. The housing component includes a housing body and an annular sealing element connected to an atrial end of the housing body. The annular sealing element is made of polyester and is reinforced with wire. A valve component is configured to be radially expandable and compressible between a radially compressed state and a radially expanded state within the housing component. The valve component includes a valve body having a valve passage extending therethrough and three leaflets made from pericardium secured to the valve body.

A heart valve prosthesis can be delivered within a native heart valve annulus using a delivery system that encases the heart valve prosthesis and sequentially permits expansion of a valve clasper and a lattice frame of the valve prosthesis. A sheath of the delivery system can be proximally retracted to permit the sinus locator to expand. Thereafter, a tubular member can be actuated to permit expansion of the lattice frame. Further, a clasper pusher of the delivery system, coupled to the tubular member, can be used to release a proximal portion of the sinus locator after release of the lattice frame. The delivery system can enable sinus locator engagement within the native annulus, sandwiching native valve leaflets between the expanded lattice frame and sinus locator, and thereafter permit disengagement of the sinus locator from the clasper pusher after the lattice frame expands.

The invention relates to a method to reduce the calcification of a biological heart valve prosthesis by a titanium containing coating in combination with UV irradiation. The method for treating the biological heart valve prosthesis with a titanium containing coating, particularly a glutaraldehyde-fixed pericardium, comprising the steps of: a) treating the biological heart valve prosthesis with a titanium containing coating; and b) irradiating the treated biological heart valve prosthesis with light of a wavelength between 100 nm and 450 nm. This results in a biological heart valve prosthesis by a hypothesized polymerization with a homogenous surface.

This invention provides a loading system and loading method. The loading system includes a main body, a receiving plate, and a receiving tube. The main body has a gripping channel extending through it axially. The receiving plate has a first central through hole extending through it axially. A plurality of first limiting grooves are circumferentially spaced along the first central through hole on one end face of the receiving plate. The first limiting grooves extend radially along the first central through hole. A plurality of second limiting grooves are circumferentially spaced on the inner wall of the receiving tube. The second limiting grooves extend through it axially. One end of the receiving plate with the first limiting grooves can be connected to the main body, and the receiving tube can be connected to the end of the receiving plate away from the main body, so that the lumen of the receiving tube, the first central through hole, and the gripping channel are coaxially connected, and the plurality of second limiting grooves are arranged in a one-to-one correspondence with the plurality of first limiting grooves. By using the loading system to grip a heart valve prosthesis with a flange and a gripper, and loading the gripped heart valve prosthesis into the delivery device, the loading quality can be effectively improved.

The disclosure relates to a heart valve prosthesis with a variable sealing function, a method for replacing a native heart valve with a heart valve replacement prosthesis with a variable sealing function and the use of a heart valve replacement prosthesis with a variable sealing function for treating a heart valve disorder.

A prosthetic heart valve assembly includes a heart valve prosthesis including an annular frame extending along a valve axis between a first valve end of the heart valve prosthesis and a second valve end of the heart valve prosthesis. The annular frame includes a plurality of frame members and is adjustable between a radially-collapsed configuration and a radially-expanded configuration. The heart valve prosthesis includes a plurality of prosthetic leaflets attached to the annular frame. The prosthetic heart valve assembly includes an anchoring element positioned within the heart valve prosthesis. The anchoring element includes a support frame that contacts the annular frame and applies an outward radial force to the annular frame in a radial direction away from the valve axis. Methods of implanting a heart valve prosthesis are provided.

A capsule guide tube for use with a loading system for loading a heart valve prosthesis into a delivery device includes an unlocked configuration and a locked configuration. The capsule guide tube includes a body and a locking member. The body is a one-piece tube configured to be disposed around a distal portion of the delivery device. The locking member is configured to releasably secure the body to a delivery device. The locking member includes a proximal end, a distal end, and a lock central passageway, wherein with the capsule guide tube in the locked configuration, the lock central passageway includes a distal portion having a first diameter configured to be disposed around a proximal portion of the body and a proximal portion having a second diameter and configured to be disposed around a portion of a delivery device, wherein the second diameter is smaller than the first diameter.

Methods, devices and systems for anchoring and / or sealing a heart valve prosthesis and, in particular, a mitral valve prosthesis (202). Inflatable elements (204, 206) are used to seal and anchor the mitral valve prosthesis (202) and / or other elements associated with repairing a native mitral valve.

The invention provides a delivery device for a heart valve prosthesis. The delivery device comprises a shell, wherein a mounting space is formed in the shell; the wire guide shaft is mounted in the mounting space, and one end of the wire guide shaft is exposed on the outer side of the shell; the conveying part is arranged on the outer side of the wire guide shaft in a sleeving mode, the conveying part can move on the wire guide shaft, and one end of the conveying part is exposed to the outer side of the shell; the fixing structure is fixed to the guide wire shaft and clamped between the conveying part and the guide wire shaft, a third containing cavity is formed among the fixing structure, the conveying part and the guide wire shaft, and a valve prosthesis is fixed in the third containing cavity; the locking mechanism is arranged at the end, close to the fixing structure, of the shell, the conveying part is sleeved with the locking mechanism, the locking mechanism can rotate relative to the shell, and the locking mechanism is used for limiting movement of the conveying part on the wire guide shaft. The heart valve prosthesis delivery device can solve the technical problem that in a heart valve prosthesis delivery device, due to the fact that the delivery structure is complex, the delivery efficiency is low.