363 results about "Heart valve" patented technology

A system for crimping and expanding a medical device may include a delivery system with a handle, a catheter, and an inflatable balloon. A syringe may receive inflation media and may be configured to be received on a balloon inflation system and to be coupled to the delivery system. A crimper may have a collapsible iris assembly configured to receive the medical device therein. The crimper may be configured to mechanically couple to the balloon inflation system. The balloon inflation system may actuate the crimper to crimp the medical device onto the balloon when the medical device is received within the iris assembly. The balloon inflation system may be configured to actuate the syringe to advance the inflation media from the syringe to the balloon to expand the balloon and to expand the medical device that is crimped onto the balloon.

This application relates to prosthetic heart valves. Disclosed are embodiments of a radially collapsible and expandable prosthetic heart valve. The valve frame can have a tapered profile when mounted on a delivery shaft, with a smaller diameter at the inflow end portion than at the outflow end portion. The valve can include generally V-shaped leaflets, reducing the amount of material in the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, with longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. An angularly woven inner skirt can be axially elongated with the frame. Side tabs adjacent the leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be recessed radially inward relative to the surrounding frame portions when the valve is crimped on a delivery shaft.

The invention discloses an integrated heart valve stent with the supporting performance of an inflow end enhanced, and relates to heart valve stents. The integrated heart valve stent with the supporting performance of the inflow end enhanced comprises a main stent body, and the main stent body comprises an outflow end supporting rod, an inflow end supporting rod and a plurality of crossed supporting rods. The outflow end supporting rod is composed of a plurality of outflow end supporting rod sections, and the inflow end supporting rod is composed of a plurality of inflow end supporting rod sections. The main body support further comprises a plurality of inflow end reinforcing rods, and the inflow end reinforcing rods are arranged between the adjacent inflow end supporting rod sections. The main body support is further provided with a plurality of sets of positioning pieces used for being inserted into the sinus bases of the heart valves, and the positioning pieces are connected with the cross supporting rods. Through the arrangement, the supporting capacity of the inflow end of the heart valve stent is improved, so that the friction anchoring force between the valve and the annulus tissue is enhanced, and the displacement risk of the heart valve stent is reduced.

In some examples, a method of manufacturing a prosthetic heart valve includes providing a stent and a valve assembly, the valve assembly including at least one of an inner cuff and an outer cuff, and a plurality of leaflets, sputter coating a layer of one or more target materials onto a surface of at least one component selected from the plurality of leaflets, the inner cuff and the outer cuff, and coupling the valve assembly to the stent.

An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.

The invention discloses a heart valve segmentation method based on edge and important content perception, which adopts an encoder and decoder architecture and comprises the following steps of: firstly, transmitting a heart CT (Computed Tomography) image into the first three layers of encoding stages of an encoder; in each coding stage, multi-direction edge information and local shape features are extracted through a mixed feature enhancement module constructed by a multi-direction learnable Sobel convolutional layer and a standard convolutional layer; then, the local features are transmitted to the last two layers of coding stages; and finally, respectively transmitting each coding feature into a corresponding decoding stage for decoding so as to generate a heart valve segmentation result. According to the method, a staged and progressive feature coding mode is designed, multi-direction edge and local shape features of the heart CT image in the shallow coding stage and important content information of the heart CT image in the deep coding stage are effectively learned, and important details of the heart valve are learned, so that the segmentation effect is better improved, and the segmentation efficiency is improved. And a certain technical support is provided for the diagnosis requirements of clinicians.

The invention discloses an interventional heart valve stent with staggered folding valve leaflets.The heart valve stent is in a circular ring shape, the heart valve stent comprises basic units which are repeatedly arranged in the circumferential direction, each basic unit comprises a compressible structure, and at least one compressible structure is of an inwards-concave structure; the main body structure is sequentially provided with three areas in the circumferential direction, the three valve leaflets are fixed to valve leaflet suture point positions of the three areas respectively, two side end suture point positions, located at the two ends of the circumferential direction, of each valve leaflet are fixed to the compressible structure, and the axial compression displacement of the two edge point positions is different. According to the stent structure, when the valve is pressed and held out of the conveying sheath tube, the valve leaflets are pulled to be distributed in a staggered mode in the axial direction through displacement of the valve frame and valve leaflet suture points, the number of valve leaflet folding layers is reduced, damage caused by mutual extrusion of the valve leaflets is relieved, and therefore the long-term durability rate of the valve after the valve is implanted into a human body is improved.

Valve repair devices are disclosed herein. One valve repair device has a main shaft and a pair of paddles. The pair of paddles include a connection portion, an inner paddle portion, and an outer paddle portion. Each connection portion of the pair of paddles is connected to the main shaft. The pair of paddles are moveable between an open position and a closed position.

A collapsible and expandable prosthetic mitral valve stent is provided with improved recapture into a distal lumen of a delivery sheath. Various embodiments comprise a valve support within the interior of a stent frame and defining a flow channel therethrough, wherein the top or upstream of the valve support comprises a row, or a plurality, of stent cells that are bent radially inward at least partially over the flow channel. Some embodiments may comprise a recapture assist mechanism, such as an open paddle, attached to one or more of the inwardly bent stent cells and adapted to receive and / or engage a wire to aid in positioning, expansion, recapture and / or implanting the device in a patient's heart chamber.

An automated system that can be used for prosthetic heart valve manufacturing or suturing procedures. The system includes automated fixtures that maneuver a needle and a target device. The automated fixtures can be suturing arms, target device holders, needle transfer fixtures, and / or needle holders. The automated fixtures can rotate a target device held by the holder to allow one or more additional automated fixtures to perform operations such as form sutures on the target device without intervention of a human operator. The system can include a display system configured to display status information of a suturing procedure.

A replacement heart valve comprises a unibody, folded, double-wall stent, with a stent cover and a leaflet valve attached to the inner lumen of the stent. The heart valve is delivered using a multi-pulley, suture-based stent restraint assembly provided by fixed guide openings or structures along the distal end of the delivery system that independently permits expansion of the distal and proximal ends of the outer wall of the stent, and control of the inner wall expansion simultaneously with or separately from the expansion of the outer wall.

The invention relates to a heart valve docking device and a system for treating a native valve of a patient. In various embodiments, the device is configured to repair a native heart valve or to secure a prosthetic heart valve within a native valve of a patient's heart. An embodiment of the apparatus includes at least an upper coil and a lower coil, wherein the apparatus is configured to assume an axially expanded state in which the entire upper coil is positioned on a first side of the lower coil relative to the central axis and an axially compressed state in which at least a portion of the upper coil is positioned on a second side of at least a portion of the lower coil opposite the first side relative to the central axis.

The utility model relates to the technical field of interventional medical instrument in-vitro simulation demonstration, in particular to a structural heart disease interventional medical instrument in-vitro simulation demonstration device. The device comprises a model fixing device (3), a heart model (31) and a detachable valve leaflet model (32) are fixed on the model fixing device (3), a camera (5) is further arranged on the device, and the device can be used for simulation device demonstration of heart valve intervention medical instrument in-vitro performance research, instrument operation training of an operator in vitro and operation process practice.

The present invention provides a method for using prostheses, such as replacement heart valves, to be delivered and / or controlled to a desired location within the body. [Solution] A foldable and expandable frame comprising rows of cells may include a plurality of axial connecting portions extending between the top and bottom ends of the cells, each axial connecting portion being shaped to bend to accommodate transient changes in cell height during uneven compression of the replacement heart valve. The frame is advantageous when advancing the replacement heart valve through a funnel-shaped compression tool. The axial connecting portions are sufficiently flexible to accommodate changes in the frame shape during compression, while also being sufficiently resilient to reinforce the structural integrity of the frame in the fully deployed state. The replacement heart valve is preferably a double-frame heart valve, where the axial connecting portions form part of the inner frame, and the outer frame is provided to engage with tissue and form a seal.

A delivery system for delivering a prosthetic valve in a compressed condition over an inner shaft of a catheter. The delivery system includes a tip extending distally from the inner shaft. The tip has a proximal section and an opposite distal section extending to an end of the tip. The proximal section is configured to support an end of the prosthetic valve during loading and delivery of the prosthetic heart valve and includes a first portion, a second portion, and a third portion. The first portion is adjacent the distal section. The second portion is between the first portion and third portion. The third portion is adjacent a proximal end of the tip. An outer diameter of the first portion is greater than an outer diameter of the inner shaft, an outer diameter of the second portion, and an outer diameter of the third portion.

A transfemoral delivery system for implanting a replacement heart valve is provided. The replacement heart valve includes an expandable frame and a plurality of distal anchors. The delivery device includes an outer sheath assembly, a mid-shaft assembly, and an inner assembly, wherein the outer sheath assembly and the mid shaft assembly retain the replacement heart valve in a radially compacted state. The outer sheath assembly is retracted relative to the mid-shaft assembly to release the distal anchors while a portion of the replacement heart valve remains retained by the mid shaft assembly. After the distal anchors engage leaflets of the native heart valve, the retained portion of the replacement heart valve is released from the mid-shaft assembly and is allowed to fully expand.

The present application relates to the technical field of medical devices, and discloses a method for simulating stress distribution of a guide wire on a heart valve and perivalvular tissue, comprising: obtaining image data of the heart valve and perivalvular tissue of a patient before surgery, and obtaining strain of each structure; constructing a material constitutive equation of the heart valve and perivalvular tissue to determine stress-strain relationship of each structure under different stress conditions; determining first stress distribution of the heart valve and perivalvular tissue according to the strain of each structure in the heart valve and perivalvular tissue and the stress-strain relationship of each structure under different stress conditions; obtaining second stress distribution of the guide wire when the guide wire is in different morphological positions in the heart valve; and determining third stress distribution of the guide wire on the heart valve and perivalvular tissue when the guide wire is in different morphological positions in the heart valve according to the first stress distribution and the second stress distribution, so as to accurately perform intraoperative navigation of the guide wire.

The invention discloses a valve preparation method. The method comprises the following steps: performing decellularization treatment on a bovine pericardium material to be treated; enhancing the porosity of the decellularized bovine pericardium material through a physical and / or chemical method so as to promote the regeneration of native valve leaflet cells and tissues, and obtaining a composite material; and cutting the leaflet of the composite material to obtain the valve. The bovine pericardial valve which is high in durability, free of anticoagulation, excellent in biocompatibility, excellent in calcification resistance and low in immunogenicity can be prepared, and therefore the purpose of treating heart valve diseases is achieved.

A valve repair device, e.g., for treating mitral valve regurgitation, includes a tubular body defining a longitudinal axis, paddles supported by the tubular body and movable to change abduction of the paddles relative to the longitudinal axis, and retention members supported by the tubular body proximal the paddles and similarly movable to change abduction of the retention members relative to the longitudinal axis to facilitate capture of native valve leaflets between pairs of paddles and retention members. Movement of the paddles and / or retention members is provided by one or more control mechanisms including a collar a shaft extending within the tubular body. Each shaft is threadedly engaged to a respective collar and coupled to one or more of the movable elements such that, when the collar is rotated, the shaft translates to change abduction of the movable element relative to the longitudinal axis.

Medical delivery system for accessing a tricuspid valve via an inferior vena cava, including an outer guide catheter, an inner guide catheter and an interventional catheter. The first deflection portion of the outer guide catheter is steerable to define a first outer-guide-catheter curve and the second deflection portion of the outer guide catheter is steerable to define a second outer-guide-catheter curve and the first deflection portion of the inner guide catheter is steerable to define a first inner-guide-catheter curve.

A magnetic heart valve for a cardiovascular simulator based on magnetic field operation and a manufacturing method thereof, and a soft magnetically regulated heart valve apparatus using the same is disclosed. This magnetic heart valve includes magnetic particles, and an elastic silicone composite material, it has a circular plate shape, at least one heart valve shape is formed within the circular plate shape, and at least one heart valve shape is apart from each other to allow the circular plate shape to freely bend upward or downward.

A capsule of a delivery system for a transcatheter heart valve prosthesis includes markers for rotationally orienting the capsule within a native valve. The capsule includes markers that are sized and located on the capsule such that when viewed in a cusp overlap viewing angle image, the markers indicate whether the capsule is in a desired rotational orientation. Methods for rotationally aligning a capsule of a delivery system containing a transcatheter heart valve prosthesis within a native valve are also provided.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support coupled to a stent configured to be implanted within a vessel, e.g., the superior vena cava, to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal, delivery portion detachably coupled, in a delivery state, to a distal, implantable portion coupled to the prosthetic device. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow therethrough in one direction during diastole, but prevents blood regurgitation during systole. The stent further may include features configured to resist migration of the stent within the vessel, as well as to prevent in-folding of the stent during deployment.

A prosthetic heart valve may include an expandable stent having a plurality of struts forming cells connected to one another in a plurality of annular rows around the stent, a cuff attached to an annulus section of the stent by cuff sutures that have a plurality of stitches extending through material of the cuff and looping around the struts, and a plurality of leaflets each having a belly attached to the cuff within an interior region of the stent. The leaflets may together have a coapted position occluding the interior region of the stent and an open position in which the interior region is not occluded. The belly of each leaflet may be attached to the cuff by leaflet sutures extending in a path that crosses some of the struts in overlap zones. Those struts may be devoid of the stitches within the overlap zones.

A tissue culture system, comprising: a support configured to be rotated about an axis of rotation; and one or more culture vessels configured to be mounted to at least a portion of the support, a culture vessel comprising: (i) a chamber configured to receive a biological tissue, and (ii) a conduit in communication with the chamber and configured to facilitate a flow of a composition, wherein the support is configured to cause rotation of the one or more culture vessels during rotation of the support, and wherein the conduit is configured to allow for flow of the composition through the chamber during rotation of the culture vessel. Related methods and tissue treatment compositions are also provided.

A delivery system includes a delivery catheter that is releasably coupled to a fixation device and a delivery handle that is coupled to the delivery catheter. A lock control assembly of the delivery handle has a releasable lock line handle operable to lock and unlock components of the fixation device. The lock line handle has a shaft body and a lever arm that respectively define first and second openings. A lock line extending from the fixation device and through the delivery catheter has a first end portion fixedly coupled to the lock line handle and a second end portion that extends through the first and second openings. The lock line is free to move through the openings when the lever arm is in a first position and is secured when the lever arm is in a second position.

Disclosed herein are delivery systems and methods for delivering a prosthetic heart valve to a native heart valve of a heart. An exemplary delivery system may include a shaft portion having at least one shaft, at least one steering wire, and at least one pull wire. The system may further include a handle portion coupled to a proximal end of the shaft portion and a capsule portion coupled to a distal end of the shaft portion. The capsule portion may be configured to house the prosthetic heart valve. At least one portion of the delivery system may be configured to be engaged with the prosthetic heart valve when the prosthetic heart valve is implanted in the native heart valve of the heart.

In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging of a heart valve in a pre-operative state. The method includes generating a segmented heart valve by segmenting the heart valve of the 3D imaging. The method includes simulating a surgical procedure on the parameterized heart valve. The method includes determining at least one post-operative outcome based on simulating the surgical procedure on the parameterized heart valve. Systems and machine-readable media are also provided.