678 results about "Heart valve" patented technology

An intravascular blood pump includes a pump housing having an input port and an output port. A relatively short intake cannula may draw blood in through an intake port and deliver the blood to the input port of the pump housing. The intake cannula is relatively short, to prevent excess hydraulic loss. An outflow hose is connected to the output port of the pump housing, so as to convey blood exiting the output port through the outflow hose in a downstream direction to a discharge port, e.g. into an aorta or other blood vessel. Despite the short intake cannula, the outflow hose longitudinally separates the intake port from the discharge port sufficiently so the intake port and the discharge port remain on opposite sides of a heart valve, despite inadvertent longitudinal shifts of the intravascular heart pump.

A prosthetic heart valve and associated methods for assembling a prosthetic heart valve including a plurality of leaflets is disclosed. As one example, a prosthetic heart valve includes a frame; a plurality of commissure support elements, each connected the frame and including two axially-extending members spaced apart from one another to form a window; and a plurality of leaflets, each leaflet comprising a body and two opposing commissure tabs, each commissure tab arranged adjacent to another commissure tab to form a pair of commissure tabs that are disposed in a commissure support element to form a commissure. Each commissure tab includes a series of overlapping layers that include a first set of two overlapping layers that extends through the window and a second set of two overlapping layers that extends away from the first set of two overlapping layers and over an outer side of a corresponding axially-extending member.

A high-performance near-pure zinc alloy, a preparation method therefor and a use thereof, relating to the technical field of zinc alloys. The alloy component is that the content of Zn is greater than or equal to 99.5%, and the remaining trace alloy elements include at least two of the following 14 elements: Mg, Mn, Li, Cu, Ag, Ca, Sr, Fe, Zr, Ti, Al, C, Ga, and Si. The alloy has the yield strength ≥ 250 MPa, the tensile strength ≥ 320 MPa, the elongation ≥ 25%, the mechanical property change during one year of room-temperature storage ≤ 5%, the maximum bending force ≥ 2 kN, the stress corrosion sensitivity factor ≤ 15%, the size of corrosion pits after 60 days of immersion ≤ 15 μm, and the standard deviation of the size of corrosion pits ≤ 3 μm. The alloy is suitable for the preparation of biodegradable stents, bone implant devices, medical staplers or anastomotic nails for intestines, blood vessels or nerves, vascular clamps, guided bone or tissue regeneration membranes, heart valve protheses, dura mater repair membranes, soluble bridge plugs and fracturing balls for oil drilling, zinc alloy die castings, electroplated zinc materials, building zinc materials, battery-grade zinc, printing-grade zinc, and zinc-based brazing alloys.

The present invention discloses a prosthetic heart valve comprising at least two valve components, a sealant covering the valve components, and an edge-sealing structure. A space is formed between the valve components covered with the sealant. The edge-sealing structure has a closed end face and connects the ends of the sealant to form a closed space within the space. The prosthetic heart valve provided by the present invention can reduce the risk of thrombosis between the valve components. Because the edge-sealing structure is flexible, it has little effect on the compression and gripping of the prosthetic valve, and the addition of the edge-sealing structure does not affect the normal function of the prosthetic valve.

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the valve; a system including the coaptation assistance element and anchors for implantation; a system including the coaptation assistance element and delivery catheter; and a method for transcatheter implantation of a coaptation element across a heart valve.

This disclosure relates to a catheter system for introducing a heart valve stent into the body of a patient. The catheter system includes a catheter tip having a seat portion for accommodating the stent in its collapsed state and a stent holder for releasably fixing the stent, wherein the seat portion is constituted by a first sleeve and a second sleeve, said sleeves being moveable relative to each other and relative to the stent holder, and a catheter shaft for connecting the catheter tip to a handle.

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the valve; a system including the coaptation assistance element and anchors for implantation; a system including the coaptation assistance element and delivery catheter; and a method for transcatheter implantation of a coaptation element across a heart valve.

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the valve; a system including the coaptation assistance element and anchors for implantation; a system including the coaptation assistance element and delivery catheter; and a method for transcatheter implantation of a coaptation element across a heart valve.

The invention relates to the field of medical instruments, in particular to a heart valve. The invention provides a heart valve. The heart valve comprises a stent body, a skirt edge and developing points. The skirt edge is connected to the bracket body; the skirt edge comprises an inner skirt edge and an outer skirt edge; the inner skirt edge and the outer skirt edge form an interlayer; the developing points are arranged in the interlayer; the number of the developing points is at least two; at least two developing points are in the same or different annular cross sections. Developing points are arranged in an interlayer; the setting mode can physically isolate the developing point, and the direct contact between the bracket and the developing point is eliminated through physical isolation; the galvanic corrosion risk can be effectively avoided, and the service life of instruments is prolonged; the metal ion release risk is reduced, and the biological safety is improved. And the developing points are arranged in the interlayer between the inner skirt edge and the outer skirt edge, so that the overall position of the valve can be reflected more accurately.

The invention provides a heart valve regurgitation detection method and system and a medium. The method comprises the steps that regurgitation area identification caused by heart valve structure or function abnormity is obtained; performing principal component analysis on the regurgitation area, and determining the main extension direction of the regurgitation of the corresponding heart valve; determining at least one morphological characteristic parameter of the reflux region according to the main extension direction; and determining the regurgitation state information of the heart valve according to the morphological characteristic parameters. According to the method, the spatial distribution of a reflux region is subjected to characteristic decomposition through principal component analysis, a complex irregular blood flow form is converted into a main extension direction with definite physical significance, and form characteristic parameters are calculated based on the main extension direction; random errors caused by subjective view angle differences or insufficient experience when valve reflux parameters are manually measured can be eliminated, and valve reflux evaluation results obtained by different operators under different detection conditions have high consistency and repeatability.

A prosthesis assembly includes a stent frame that is expandable and configured for being positioned in the ascending aorta, and a receiving socket positioned within a proximal end of the prosthesis assembly. The receiving socket defines a recess for allowing flowthrough of blood into the stent frame. The receiving socket is further configured for selectively receiving a heart valve assembly for replacing a native heart of a patient or maintaining a mode of operation where the socket is empty and blood flows through the socket into the stent frame.

A funnel crimper includes a body having a tapered portion, an extended outflow portion, and a tissue compressor. The tissue compressor is configured to apply a radially inward force to tissue of a prosthetic valve of a transcatheter heart valve prosthesis disposed on an inner surface of a frame of the transcatheter heart valve prosthesis as the transcatheter heart valve prosthesis is advanced through a lumen of the funnel crimper. The tissue compressor may be a ring of relatively soft material extending into the lumen of the funnel crimper or pressurized fluid applied radially inward to the lumen of the funnel crimper.

The application provides a valve support and an artificial valve with the same, and belongs to the technical field of heart valves. The valve support comprises a support body, a positioning ring and an elastic connecting wire. The positioning ring is arranged in a compressed state and is adapted to be sequentially and serially arranged along an axis with the support body. When the positioning ring is elastically deformed from the compressed state to an expanded state, the positioning ring can be coaxially sleeved on the support body through the traction of the elastic connecting wire. After the valve support is implanted, the positioning ring can be self-expanded to the expanded state through elastic deformation and can be coaxially sleeved on the support body according to the traction of the elastic connecting wire. Therefore, the positioning ring and the support body can be simultaneously positioned during the implantation operation. Due to the traction of the connecting wire, the support body can be self-positioned according to the positioning ring, thereby saving the separate positioning operation of the positioning ring and the support body and making the operation more convenient.

A system for cutting leaflet tissue at a cardiac valve may comprise a guide catheter having a proximal end and a distal end, wherein the distal end of the guide catheter is steerable to a position above a cardiac valve. The system may also include a handle coupled to the proximal end of the guide catheter, the handle comprising at least one control configured to steer the guide catheter to the position above the cardiac valve. Finally, the system may comprise a cutting mechanism routable through the guide catheter and able to be positioned at the distal end of the guide catheter, the cutting mechanism configured to cut a portion of leaflet tissue of the cardiac valve.

The invention discloses a construction method and application of a mouse model for specifically tracing heart valve cells, and belongs to the technical field of animal model construction. The model construction method comprises the following steps: (1) constructing a Wid1-Cre hybrid mouse before inserting a Cre recombinase coding gene into a termination codon of a mouse Wid1 gene; and (2) hybridizing the Wid1-Cre hybrid mouse with the Rosa26-tdTomato homozygous report mouse, so as to obtain the double transgenic mouse which simultaneously carries the Wid1-Cre gene and the Rosa26-tdTomato gene. According to the invention, on the basis of the expression characteristic that Wif1 is only limited to a valve area in the heart, Wif1-Cre is constructed; according to the Rosa26-tdTomato mouse model, specific tracing of heart valve cells is achieved, and an important experimental tool is provided for mechanism research of heart valve diseases and development of therapeutic drugs.

This disclosure relates to a heart valve with improved functionality and durability.

Apparatuses, systems, and methods for prosthetic valves having sensor systems are disclosed. Examples of prosthetic valves include replacement heart valves for replacing the function of a native heart valve, such as a mitral or tricuspid valve. In various embodiments, replacement heart valves are provided with sensors or markers for assisting with proper placement and / or securement in the body. A replacement heart valve may include anchors for securing the replacement heart valve to native leaflets, wherein sensors and / or markers provide feedback to the physician for confirming proper placement of the anchors during the implantation procedure. Sensors may also be used to assess the function of the prosthetic valve after deployment. Sensors may also be used to monitor blood pressure, temperature, oxygen, insulin, cholesterol, and / or glucose to assess overall patient health.

A heart valve prosthesis comprising a radially expandable and compressible annular frame is disclosed. The frame comprises a plurality of interconnected rows of cells disposed between an inflow end and an outflow end of the frame, the interconnected rows of cells comprising a plurality of outflow struts defining the outflow end and a plurality of inflow struts defining the inflow end. The frame further comprises a plurality of tip regions formed at the inflow end and the outflow end, each tip region curved between two angled strut portions and forming one of the outflow struts or one of the inflow struts with the two angled strut portions.Each tip region has a reduced width and a length extending at least 25% of the total length of the outflow strut or the inflow strut, the reduced width being less than the width of the two angled strut sections.

Prosthetic heart valves may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valve includes structural features that securely anchor the prosthetic heart valve to the anatomy at the site of the native heart valve. Such structural features can provide robust migration resistance. In addition, the prosthetic heart valves can include structural features that improve sealing between the prosthetic valve and native valve anatomy to mitigate paravalvular leakage. In particular implementations, the prosthetic heart valves occupy a small delivery profile, thereby facilitating a smaller delivery catheter system for advancement to the heart. Some delivery catheter systems can include a curved inner catheter to facilitate deployment of the prosthetic heart valve to a native tricuspid valve site via a superior vena cava or inferior vena cava.

A system for crimping and expanding a medical device may include a delivery system with a handle, a catheter, and an inflatable balloon. A syringe may receive inflation media and may be configured to be received on a balloon inflation system and to be coupled to the delivery system. A crimper may have a collapsible iris assembly configured to receive the medical device therein. The crimper may be configured to mechanically couple to the balloon inflation system. The balloon inflation system may actuate the crimper to crimp the medical device onto the balloon when the medical device is received within the iris assembly. The balloon inflation system may be configured to actuate the syringe to advance the inflation media from the syringe to the balloon to expand the balloon and to expand the medical device that is crimped onto the balloon.

This application relates to prosthetic heart valves. Disclosed are embodiments of a radially collapsible and expandable prosthetic heart valve. The valve frame can have a tapered profile when mounted on a delivery shaft, with a smaller diameter at the inflow end portion than at the outflow end portion. The valve can include generally V-shaped leaflets, reducing the amount of material in the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, with longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. An angularly woven inner skirt can be axially elongated with the frame. Side tabs adjacent the leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be recessed radially inward relative to the surrounding frame portions when the valve is crimped on a delivery shaft.

A prosthetic heart valve includes an annular frame having an inflow end and an outflow end, a leaflet structure comprising a plurality of leaflets positioned within the annular frame, and an inner skirt disposed on an inner surface of the annular frame. The leaflet structure is movable between an open state which permits blood flow from the inflow end to the outflow end and a closed state which blocks blood fluid flow from the outflow end to the inflow end. Each leaflet includes a main body and two opposing sub-commissure tabs arranged on opposite sides of the main body. Each sub-commissure tab is paired with and connected to an adjacent sub-commissure tab of an adjacent leaflet. Pairs of sub-commissure tabs extend through adjacent gaps formed in the inner skirt.

The invention discloses an integrated heart valve stent with the supporting performance of an inflow end enhanced, and relates to heart valve stents. The integrated heart valve stent with the supporting performance of the inflow end enhanced comprises a main stent body, and the main stent body comprises an outflow end supporting rod, an inflow end supporting rod and a plurality of crossed supporting rods. The outflow end supporting rod is composed of a plurality of outflow end supporting rod sections, and the inflow end supporting rod is composed of a plurality of inflow end supporting rod sections. The main body support further comprises a plurality of inflow end reinforcing rods, and the inflow end reinforcing rods are arranged between the adjacent inflow end supporting rod sections. The main body support is further provided with a plurality of sets of positioning pieces used for being inserted into the sinus bases of the heart valves, and the positioning pieces are connected with the cross supporting rods. Through the arrangement, the supporting capacity of the inflow end of the heart valve stent is improved, so that the friction anchoring force between the valve and the annulus tissue is enhanced, and the displacement risk of the heart valve stent is reduced.

The application provides a perfusion balloon catheter with a one-way valve, comprising: a balloon body part; the balloon body part comprises an inner lumen tube and a plurality of balloons arranged around the outer surface of the inner lumen tube; the distal balloon tube leg of the plurality of balloons is in contact with the tube wall of the inner lumen tube; a one-way valve is arranged between the inner lumen tube and the balloon part of the balloon. Compared with the prior art, the perfusion balloon catheter provided by the application is formed by a plurality of balloon clusters, and after expansion, a hollow cylindrical shape is formed, and a one-way valve is arranged in the cavity, which is used to simulate the leaflets in the heart valve, and the one-way valve is enabled after the balloon is opened, without the need for switching operation, and the structure is stable, and the function of the leaflets can be realized for multiple times; in addition, the design of the cluster balloon can reduce the difficulty of the balloon forming process while meeting the expected function.

A replacement heart valve implant includes an expandable framework including a tubular wall comprising a plurality of interconnected struts and defining a central lumen, wherein the wall includes inflow and outflow ends, and a plurality of commissure posts. A plurality of valve leaflets is secured to the commissure posts. The framework may include a plurality of native leaflet clamps extending upstream from the outflow end, wherein the leaflet clamps are configured to pinch native leaflets of the native heart valve against the wall. The framework may include a plurality of native commissure clamps extending upstream from the commissure posts, wherein the commissure clamps are configured to pinch native commissures of the native heart valve. The framework may include a plurality of native leaflet clamps extending upstream from the commissure posts, wherein the leaflet clamps are configured to pinch native leaflets of the native heart valve against the wall.

A heart valve assembly has a valve frame having a cylindrical body with commissure posts connected to an outflow end, and a leaflet assembly sutured to the plurality of commissure posts and the valve frame. The assembly also has an outflow frame having a plurality of connection posts, with each connection post connected to one of the commissure posts. The valve frame and the annulus frame are made from different materials. A delivery system has a balloon catheter having a shaft, a balloon provided on the shaft adjacent the distal end of the catheter, and a frame seat located on the shaft directly proximal to the balloon. The delivery system includes a sheath assembly having a capsule that slidably covers the balloon and the frame seat such that the outflow frame is seated around the frame seat and the valve frame is seated over the balloon.

In some examples, a method of manufacturing a prosthetic heart valve includes providing a stent and a valve assembly, the valve assembly including at least one of an inner cuff and an outer cuff, and a plurality of leaflets, sputter coating a layer of one or more target materials onto a surface of at least one component selected from the plurality of leaflets, the inner cuff and the outer cuff, and coupling the valve assembly to the stent.

A catheter system (100) usable for treating a treatment site (106) within or adjacent to a vessel wall (108A) of a blood vessel (108) or a heart valve within a body (107) of a patient (109), the catheter system (100) can include an energy source (124) that generates energy, a catheter (102) that includes an energy guide (122A) that receives the energy from the energy source (124), and a system controller (126) that is coupled to the energy source (124), the system controller (126) being configured to: (i) monitor real-time operating parameters of the catheter system (100), including at least energy delivery characteristics and treatment site conditions, (ii) detect and identify operating parameters that require adjustment, (iii) automatically adjust operating parameters, and (iv) dynamically provide a summary of system status, treatment progress, and actionable alerts.

An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.