49 results about "PROSTHETIC MITRAL VALVE" patented technology

The present invention provides a prosthetic heart valve device with improved fit and / or apposition between the device frame and left atrial tissue and / or the device base and the annular tissue of the left atrium to improve shifting of the implanted device and / or mitigate paravalvular leakage. The improved fit and / or apposition arises in various embodiments by providing or allowing an asymmetrical frame and / or frame base and / or providing a lower lip to aid in conforming to the asymmetrical shape of the atrium and / or ensure firm positioning therein. An additional benefit of these arrangement(s) is mitigation of paravalvular leakage as a result of improved fit and seal. In certain embodiments, the asymmetry of the frame assists with delivery of the device into the atrium.

A collapsible and expandable prosthetic mitral valve stent is provided with improved recapture into a distal lumen of a delivery sheath. Various embodiments comprise a valve support within the interior of a stent frame and defining a flow channel therethrough, wherein the top or upstream of the valve support comprises a row, or a plurality, of stent cells that are bent radially inward at least partially over the flow channel. Some embodiments may comprise a recapture assist mechanism, such as an open paddle, attached to one or more of the inwardly bent stent cells and adapted to receive and / or engage a wire to aid in positioning, expansion, recapture and / or implanting the device in a patient's heart chamber.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

The invention discloses a lantern-shaped variable-diameter transcatheter artificial mitral valve stent, and belongs to the technical field of medical instruments. Comprising a lantern-shaped outer stent body and an outer stent covering film, the outer stent covering film is arranged close to an aorta side semi-open window, and the outer stent covering film is arranged close to the aorta side semi-open window. The grid lantern-shaped support body comprises an atrial side umbrella disc, a ventricular side variable diameter structure and a negative pressure suction cup which is connected with the atrial side umbrella disc and the ventricular side variable diameter structure and used for strengthening anchoring. The valve inner frame comprises a grid barrel-shaped inner frame body and an inner frame covering film, and the inner side of the inner frame body is connected with an artificial valve leaflet. By means of the lantern-shaped design of the outer stent and the valve ring suction cup for assisting anchoring, the problem that an artificial mitral valve replaced through a catheter is difficult to anchor is solved, and the problem that a left ventricular outflow tract is prone to being blocked after a covered stent is implanted is solved through the design that the single side of the dynamically-changeable valve outer stent is not covered with a film.

A collapsible and expandable prosthetic mitral valve stent is provided with improved recapture into a distal lumen of a delivery sheath. Various embodiments comprise a valve support within the interior of a stent frame and defining a flow channel therethrough, wherein the top or upstream of the valve support comprises a row, or a plurality, of stent cells that are bent radially inward at least partially over the flow channel. Some embodiments may comprise a recapture assist mechanism, such as an open paddle, attached to one or more of the inwardly bent stent cells and adapted to receive and / or engage a wire to aid in positioning, expansion, recapture and / or implanting the device in a patient's heart chamber.

A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

A collapsible and expandable prosthetic mitral valve stent is provided with improved recapture into a distal lumen of a delivery sheath. Various embodiments comprise a valve support within the interior of a stent frame and defining a flow channel therethrough, wherein the top or upstream of the valve support comprises a row, or a plurality, of stent cells that are bent radially inward at least partially over the flow channel. Some embodiments may comprise a recapture assist mechanism, such as an open paddle, attached to one or more of the inwardly bent stent cells and adapted to receive and / or engage a wire to aid in positioning, expansion, recapture and / or implanting the device in a patient's heart chamber.

A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

Valve holders and introducers for delivering a prosthetic heart valve to an implant site are in various embodiments configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. A valve holder according to embodiments of the invention includes features that reduce or eliminate mistakes during implantation of the prosthetic valves, such as a removable activator dial and a removable handle that prevent implantation of the valve prior to proper deployment or adjustment of the holder. An introducer is provided which can facilitate passing of a prosthetic valve between adjacent ribs of a patient. Valve holders and introducers according to the various embodiments can be used in minimally invasive procedures, such as thoracotomy procedures.

Apparatuses and methods are described that include a delivery device that delivers a valve frame (120) to a native mitral valve and positions the valve frame (120) such that the center of the valve frame (120) is off-centered with respect to the center of an annular plane of the annulus and is positioned towards a posterior side of the annular plane. The arms (124) of the valve frame (120) are deployed between chordae tendineae of the native mitral valve. The valve frame (120) is rotated to cause the arms (124) to pull the leaflets of the native valve radially inward. The frame body (121) of the valve frame (120) expands radially to capture the native leaflet and cause the valve frame (120) to be deployed off-center with respect to the center of the annular plane. Other applications are also described herein.

Apparatus and methods are described herein including an expandable prosthetic mitral valve device that includes a first component configured to be deployed in the left atrium of a subject and a second component configured to be deployed in a left ventricle of the subject. At least one approximating component approximates the first and second components with respect to each other, such that, when the first and said second components are in an approximated configuration with respect to each other, one or more leaflets of the native mitral valve are trapped within the gap between a ventricular part and an annulus part. The approximating component secures the annulus part and the ventricular part in the approximated configuration. Other applications are also described.

A delivery device system for an artificial mitral valve implant. A distal movable sliding block (210) is driven by means of a front rotary knob (221) to axially move to enable a main stent (101) to be exposed or stored at a target position; and a proximal movable sliding block (212) is driven by means of a rear rotary knob (222) to axially move to enable an inner-layer stent (102) to be exposed or stored at the target position. By means of controlling the front rotary knob (221) and the rear rotary knob (222) to rotate separately or synchronously, the main stent (101) and the inner-layer stent (102) are released separately or synchronously, the interval time is short, and the displacement influence brought about by stress relief is reduced.

Disclosed herein are embodiments of an expandable replacement heart valve prosthesis. The expandable replacement heart valve prosthesis can include a number of different features, such as an hourglass (or generally hourglass) shape in the fully expanded position, anchor stiffening features, and improved retraction / retention configurations. For example, certain struts on the prosthesis can have different thicknesses / widths than other struts to improve compressibility.

The invention relates to a device (1) for placing an artificial mitral valve chorda (30), the device comprising: - a central body (10); - two end portions (12, 14) arranged on either side of the central body (10), each comprising a through-opening (122, 142) and comprising two jaws (124, 144) defining the corresponding opening (122, 142); it being possible for each end portion (12, 14) to be placed in two distinct configurations: - a first configuration in which the jaws are in a closed position, in which position an artificial chorda strand passing through the corresponding opening (122, 142) cannot pass between the corresponding jaws (124, 144); - a second configuration in which the jaws are in an open position, in which position an artificial chorda strand passing through the corresponding opening (122, 142) can pass between the corresponding jaws.

A valve prosthesis and methods for implanting the prosthesis are provided. The prosthesis generally includes a self-expanding frame and two or more engagement arms. A valve prosthesis is sutured to the self-expanding frame. Each engagement arm corresponds to a native mitral valve leaflet. At least one engagement arm immobilizes the native leaflets, and holds the native leaflets close to the main frame. The prosthetic mitral valve frame also includes two or more anchor attachment points. Each anchor attachment point is attached to one or more anchors that help attach the valve prosthesis to the heart.

The present invention relates to prosthetic mitral valve devices. More specifically, methods, systems, and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium without engaging the left ventricle, the native mitral valve leaflets, or the annular tissue downstream of the superior annulus during delivery, and in some embodiments, the ventricle, mitral valve leaflets, and / or the annular tissue located downstream of the superior annulus are not engaged by the delivered, positioned, and expanded prosthetic mitral valve device.

Systems for mitral valve repair are disclosed where one or more mitral valve interventional devices may be advanced intravascularly into the heart of a patient and deployed upon or along the mitral valve to stabilize the valve leaflets. The interventional device may also facilitate the placement or anchoring of a prosthetic mitral valve implant. The interventional device may generally comprise a distal set of arms pivotably and / or rotating coupled to a proximal set of arms which are also pivotably and / or rotating coupled. The distal set of arms may be advanced past the catheter opening to a subannular position (e.g., below the mitral valve) and reconfigured from a low-profile delivery configuration to a deployed securement configuration. The proximal arm members may then be deployed such that the distal and proximal arm members may grip the leaflets between the two sets of arms to stabilize the leaflets.

To provide an artificial heart valve capable of aiding the functions of the mitral valve of a patient in a minimally invasive manner. An artificial heart valve 1 which includes a valve leaflet securing part 2 and valve leaflets (a first valve leaflet 5 and a second valve leaflet 7), and in which the valve leaflets are connected to the valve leaflet securing part 2 at the top portion of the artificial heart valve 1, the valve leaflets each have a region which narrows in width toward the bottom of the leaflet, and the artificial heart valve is an artificial mitral valve or an artificial tricuspid valve.

A prosthetic mitral valve includes a stent frame and an anchor assembly coupled to and peripherally surrounding the stent frame. The anchor assembly includes atrial anchors on the inflow end, ventricular anchors on the outflow end, and a central waist portion disposed therebetween. The anchor assembly generally defines an hourglass shape wherein the atrial and ventricular anchors flare radially outward and the central waist portion has a relatively smaller diameter. The prosthetic valve may include a gasket disposed peripherally around the central waist portion to seal the space between the body of the valve and the native valve annulus to prevent paravalvular leakage without increasing the profile of the valve to allow for smooth insertion into and deployment from a delivery device. The prosthetic valve may alternatively include a sealing fabric surrounding the anchor assembly defining a radial protrusion around the central waist portion to seal the native annulus.

Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and / or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

The invention belongs to the technical field of medical instruments, and particularly relates to an artificial mitral valve implant conveying system which comprises a guide wire, a conveying pipe is slidably connected to the outer surface of the guide wire, a suction assembly is fixedly connected to the bottom end of the conveying pipe, and a first protection assembly is fixedly connected to the bottom end of the outer surface of the conveying pipe. The top end of the outer surface of the conveying pipe is fixedly connected with a second protection assembly, and the middle of the outer surface of the conveying pipe is fixedly connected with a first electromagnetic block. Through the arranged first protection assembly, under the action of the first electromagnetic block, the second electromagnetic block is attracted, the second storage cavity can be driven to be far away from the first storage cavity, unlocking and releasing of the frame body can be achieved, operation is easy, convenient and rapid, the controllability of the releasing process is high, and the releasing sequence is that the upper support is released firstly, and after the upper support is completely unfolded and fixed, the second storage cavity can be driven to be far away from the first storage cavity. And then the first accommodating cavity is moved downwards to release the lower stent, so that the stable orientation of the stent system in the implanting process can be ensured.

A low-profile prosthetic valve for treating a native valve includes a radially expandable frame having an expanded configuration and a collapsed configuration. An atrial end of the prosthetic valve forms a flared shape that engages a surface of an atrium of the native valve. The flared shape flares downward toward a ventricle of the native valve upon initial expansion, and then inverts the flared shape to form a tapered shape that tapers toward the ventricle and flares toward the atrium of the native valve upon full expansion. The prosthetic valve also has a plurality of prosthetic valve leaflets that open and close to control fluid flow through the prosthetic valve.

The present application discloses a "lantern-shaped" variable-diameter transcatheter artificial mitral valve stent, which belongs to the field of medical device technology. It includes a valve inner frame, a valve outer frame sleeved on the outside of the valve inner frame, and a connecting film connecting the valve outer frame and the valve inner frame. The valve outer frame includes a lantern-shaped outer stent body and an outer frame coating. The outer frame coating is arranged near the aorta side semi-open window. The grid lantern-shaped stent body includes an atrial side umbrella disc, a ventricular side variable diameter structure, and a negative pressure suction cup connected to the atrial side umbrella disc and the ventricular side variable diameter structure and used to strengthen anchoring; the valve inner frame includes a grid cylindrical inner stent body and an inner frame coating. The inner side of the inner stent body is connected to an artificial valve leaflet. The lantern-shaped design of the outer stent and the valve ring suction cup for auxiliary anchoring solve the problem of difficult anchoring of the artificial mitral valve during transcatheter replacement. The design of the dynamically changeable valve outer frame without coating on one side alleviates the problem of easy obstruction of the left ventricular outflow tract after implantation of the coated stent.

Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Some embodiments of prosthetic mitral valves described herein include an anchor portion that couples the prosthetic mitral valve to the anatomy near the native mitral valve, and a valve portion that is mateable with the anchor portion. Some embodiments of the transcatheter delivery system can include systems and techniques for retrieval of the anchor portions and the valve portion.

A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

A prosthetic mitral valve includes a stent frame and an anchor assembly coupled to and peripherally surrounding the stent frame. The anchor assembly includes atrial anchors on the inflow end, ventricular anchors on the outflow end, and a central waist portion disposed therebetween. The anchor assembly generally defines an hourglass shape wherein the atrial and ventricular anchors flare radially outward and the central waist portion has a relatively smaller diameter. The prosthetic valve may include a gasket disposed peripherally around the central waist portion to seal the space between the body of the valve and the native valve annulus to prevent paravalvular leakage without increasing the profile of the valve to allow for smooth insertion into and deployment from a delivery device. The prosthetic valve may alternatively include a sealing fabric surrounding the anchor assembly defining a radial protrusion around the central waist portion to seal the native annulus.