99 results about "Paravalvular leakage" patented technology

The present invention provides a prosthetic heart valve device with improved fit and / or apposition between the device frame and left atrial tissue and / or the device base and the annular tissue of the left atrium to improve shifting of the implanted device and / or mitigate paravalvular leakage. The improved fit and / or apposition arises in various embodiments by providing or allowing an asymmetrical frame and / or frame base and / or providing a lower lip to aid in conforming to the asymmetrical shape of the atrium and / or ensure firm positioning therein. An additional benefit of these arrangement(s) is mitigation of paravalvular leakage as a result of improved fit and seal. In certain embodiments, the asymmetry of the frame assists with delivery of the device into the atrium.

Apparatuses, systems, and methods for prosthetic valves. An implantation site may comprise a native heart valve or another implantation site in examples. Examples may be utilized for improved anchoring and sealing of flow (e.g., paravalvular leakage) with a native heart valve having calcification. Examples may include breaking up calcification of a native heart valve to improve deployment to the native heart valve.

Prosthetic heart valves may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valve includes structural features that securely anchor the prosthetic heart valve to the anatomy at the site of the native heart valve. Such structural features can provide robust migration resistance. In addition, the prosthetic heart valves can include structural features that improve sealing between the prosthetic valve and native valve anatomy to mitigate paravalvular leakage. In particular implementations, the prosthetic heart valves occupy a small delivery profile, thereby facilitating a smaller delivery catheter system for advancement to the heart. Some delivery catheter systems can include a curved inner catheter to facilitate deployment of the prosthetic heart valve to a native tricuspid valve site via a superior vena cava or inferior vena cava.

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments. The segments may be orthogonal or oblique to the outer surface of the tubular stent.

An implantable prosthetic valve can include a radially expandable and compressible annular frame comprising an inflow end portion and an outflow end portion, and a valvular structure comprising a plurality of leaflets arranged within the frame. The prosthetic valve can further include a sealing member having a first end portion and a second end portion, the first end portion being coupled to an inflow edge of the frame, the sealing member being movable between a delivery configuration wherein the first end portion extends proximally from the frame and a deployed configuration wherein the first end portion is everted over the inflow end of the frame such that the second end portion forms a flanged portion.

The present invention provides a prosthetic heart valve, including a stent, prosthetic leaflets and an occlusion mechanism. Both the prosthetic leaflets and the occlusion mechanism are connected to the stent. The occlusion mechanism is able to extend outwards away from the stent and fill up a recessed portion of a native valve annulus, thereby closely fitting the prosthetic heart valve against the native valve annulus and effectively preventing paravalvular leakage.

The invention discloses a valve prosthesis which comprises an inflow end and an outflow end, the valve prosthesis comprises a support, a sealing piece and a covering film, the covering film at least covers the part, close to the inflow end, of the support, the sealing piece comprises a sealing material, a first fixing piece and a second fixing piece, and the sealing material comprises a first edge and a second edge which are oppositely arranged; the first edge or an area near the first edge is fixed with the covering film through the first fixing piece, then the second edge is close to the first edge in a rolling or folding mode to form an annular structure arranged on the outer side of the covering film, and then the annular structure and the covering film are fixed through the second fixing piece, so that the sealing piece which is accurately positioned and shaped on the valve prosthesis support can be obtained. Therefore, the perivalvular leakage prevention device can better adapt to the in-vivo physiological environment, and the perivalvular leakage situation is greatly reduced.

Prosthetic heart valves may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valve includes structural features that securely anchor the prosthetic heart valve to the anatomy at the site of the native heart valve. Such structural features can provide robust migration resistance. In addition, the prosthetic heart valves can include structural features that improve sealing between the prosthetic valve and native valve anatomy to mitigate paravalvular leakage. In particular implementations, the prosthetic heart valves occupy a small delivery profile, thereby facilitating a smaller delivery catheter system for advancement to the heart. Some delivery catheter systems can include a curved inner catheter to facilitate deployment of the prosthetic heart valve to a native tricuspid valve site via a superior vena cava or inferior vena cava.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

An anchoring device (100, 200, 300) for prosthetic heart valve (400) and a prosthetic heart valve system. The prosthetic heart valve system includes an anchoring device (100, 200, 300) and a prosthetic heart valve (400). The anchoring device (100, 200, 300) includes an anchoring section (110, 210, 310) and a supporting section (120, 220, 320) that are axially connected to each other. The anchoring section (110, 210, 310) has an annular first cavity (111, 211, 311) configured to accommodate a prosthetic heart valve (400). The supporting section (120, 220, 320) is arranged on one side of the anchoring section (110, 210, 310) along the axial direction thereof. The supporting section (120, 220, 320) includes at least two elastic wires (121, 221, 321) arranged sequentially on the circumference of the anchoring section (110, 210, 310). Each elastic wire (121, 221, 321) has an end connected to the anchoring section (110, 210, 310), and a further end extending in a direction away from the anchoring section (110, 210, 310). The anchoring device (100, 200, 300) can utilize the structure of the predetermined chamber to anchor the prosthetic heart valve (400) without crossing the native valve annulus during implantation, thereby effectively preventing the occurrence of paravalvular leakage after the prosthetic heart valve (400) is implanted.

The invention provides a double-hole mitral valve replacement implant which comprises a wrapping cloth outer support and an inner valve support, the wrapping cloth outer support is arranged on the periphery of the inner valve support in a sleeving mode, and the inner valve support comprises a first inner support and a second inner support which are arranged side by side. A first bioprosthetic valve and a second bioprosthetic valve are respectively arranged in the first inner stent and the second inner stent; a containing gap is formed among the wrapping cloth outer support, the first inner support and the second inner support, a flow blocking skirt edge is arranged in the containing gap, one side of the flow blocking skirt edge is connected with the inner wall of the wrapping cloth outer support, and the other side of the flow blocking skirt edge is arranged on the periphery of the first inner support and the periphery of the second inner support in an attached mode. A tightening line is arranged on the edge, close to the first inner support or the second inner support, of the flow blocking skirt edge in a penetrating mode. The problems of perivalvular leakage and leakage of a fit clearance between the inner support and the outer support are effectively solved, and high safety is achieved.

An annuloplasty ring includes an elastic elongated core having first regions and second regions, wherein the first regions are more stretchable than the second regions and are adapted for positioning at the commissures of a target native heart valve. The first regions and the second regions may enable the annuloplasty ring to both re-establish coaptation of the leaflets of a diseased native heart valve and establish a seal around a prosthetic replacement heart to prevent paravalvular leakage after a “Valve In Ring Procedure”.

The application provides a kind of replacement valve device and its support by catheterization, it is related to heart valve technical field.The replacement valve support by catheterization includes support main body, anchoring structure, skirt support structure and sealing membrane.The sealing membrane is circumferentially closed cylindrical structure, sealing membrane includes the first sealing section and the second sealing section being arranged along the axial direction and being connected with each other, the first sealing section is tightly arranged on part or all of skirt support structure, the second sealing section is tightly arranged on part or all of support main body;Sealing membrane is arranged on the inner side and / or outer side of skirt support structure and support main body.The application can solve the problem that sealing membrane and valve support do not fit in the prior art, poor sealing, leading to sealing membrane in blood, leading to paravalvular leakage or causing other complications, with high degree of fit, good sealing, can avoid sealing membrane in blood, effectively avoid paravalvular leakage or cause other complications.

The invention relates to the technical field of medical instruments and discloses a plugging device and a plugging system, the plugging device is of a semi-closed structure, a containing cavity is formed in the plugging device, an opening of the plugging device communicates with the containing cavity, the opening is suitable for allowing fluid to flow into the containing cavity, and the plugging device is suitable for expanding under the pressure of the fluid. The plugging device can be implanted between a valve support and a heart valve ring, an opening of the plugging device faces the blood inflow side, namely the far-end side, blood flows into the plugging device through the opening of the plugging device in the flowing process, and along with increase of the blood in the plugging device, the plugging device can be used for plugging the heart valve ring. The plugging device expands after being subjected to blood pressure and can be attached to the valve stent and the heart valve ring, so that a gap between the valve stent and the heart valve ring is plugged, and the problem of perivalvular leakage can be relieved; the plugging device expands by means of blood flowing in the body, so that the plugging device can adapt to the gap between the valve stent and the heart valve ring, and the plugging effect on perivalvular leakage can be improved.

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

The present invention relates to an artificial heart valve, which comprises a valve stent, a first sealing membrane, a second sealing membrane, valve leaflets and valve leaflet anchoring members. The valve stent includes an inflow section and an outflow section; the first sealing membrane is attached to the outer side of the valve stent and comprises a hydrophilic swelling material, which can absorb liquid and swell after contacting with blood, for reducing paravalvular leakage; the second sealing membrane is arranged on the outer side of the first sealing membrane and at least covers all regions corresponding to the outer surface of the inflow section, for increasing the friction with the native valve leaflets; the valve leaflets are arranged inside the valve stent for controlling the unidirectional flow of blood; the valve leaflet anchoring members are spiral and can be coiled outside the mitral / tricuspid chordae tendineae plexus and interact with the valve stent. By providing the first sealing membrane and the second sealing membrane, the artificial heart valve of the present invention can better fit with the native tissue after being implanted into the mitral / tricuspid valve, so as to effectively prevent the occurrence of paravalvular leakage.

The application relates to the technical field of medical devices, in particular to a valve support for mitral valve replacement, which comprises an annular support formed integrally, one end of the support is provided with an anchoring part, and the other end is provided with a connecting part; the connecting part comprises a connecting arm, the connecting arm comprises a bending section and a connecting section which are connected to each other, the bending section is integrally extended from the support, and the connecting section is provided with a flexible section used for abutting against the atrial wall; the anchoring part comprises a bendable anchoring arm, one end of the anchoring arm away from the support is provided with a clamping part used for anchoring the valve, and a fixing part used for preventing the valve from rotating. The valve support has the beneficial effects that the anchoring performance of the valve support is enhanced, and the risk of paravalvular leakage is reduced.

A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

This invention discloses a valve prosthesis, including an inflow end and an outflow end. The valve prosthesis includes a support, a seal, and a cover. The cover at least covers the portion of the support near the inflow end. The seal includes a sealing material, a first fixing member, and a second fixing member. The sealing material includes a first side and a second side disposed opposite to each other. The first side or its vicinity is fixed to the cover with the first fixing member. Then, the second side is rolled or folded to approach the first side, forming an annular structure disposed on the outside of the cover. The second fixing member then fixes the annular structure to the cover. This invention provides a seal that is precisely positioned and shaped on the valve prosthesis support, thereby better adapting to the physiological environment in the body and greatly reducing the occurrence of paravalvular leakage.

The invention relates to the technical field of medical instruments, in particular to a forward torque self-locking mitral valve replacement valve stent which comprises an annular atrial umbrella disc and a plurality of flexible supporting parts which are sequentially connected in the circumferential direction to form the atrial umbrella disc. Due to the arrangement of the inner concave sections, the grid units form outer edge parts which are bent in the circumferential direction, and the bending direction of the outer edge parts is the instantaneous needle direction; the annular support anchoring disc is formed by sequentially connecting a plurality of anchoring arms in the circumferential direction, the circumferential bending direction of the anchoring arms is the same as the circumferential bending direction of the outer edge part, and the anchoring arms are matched with the grid units. The valve support has the advantages that the forward torque self-locking effect can be generated, the valve support continuously winds and hooks the chordae tendineae, the attaching force of the valve support and an original valve leaflet is kept, the valve is prevented from shifting and slipping, and the perivalvular leakage risk is reduced.

Docking devices for securing a prosthetic valve at a native valve and delivery apparatus for delivery thereof. The docking device includes a coil member that can be moved into a coiled configuration, such that the coil member includes a plurality of helical turns when deployed at the native valve. The guard member includes a plurality of fibers that can extend radially outward from an exterior surface of the coil. The guard member can be secured to the coil via one or more sutures. The guard member can be compressed within a dock sleeve during delivery of the docking device to the native valve. The dock sleeve can be withdrawn or axially moved relative to the coil member to allow the guard member to transition from the compressed state to the radially extended state. The guard member can function anchor a prosthetic valve and limit or prevent paravalvular leakage when implanted in a native heart valve.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

This invention discloses a novel valve stent and artificial heart valve, belonging to the field of medical device technology. The valve stent has a hollow, symmetrical, mesh-like tubular structure, with a first layer of hexagonal mesh groups, a second layer of polygonal mesh groups, and a third layer of polygonal mesh groups arranged sequentially from the outflow end to the inflow end. The stent has a small overall mesh count and symmetrical structure, resulting in uniform deformation during compression and expansion. It exhibits excellent radial support and minimal expansion rebound, significantly reducing the risk of paravalvular leakage. While maintaining radial support, this invention can reduce the stent strut width to 0.2–0.4 mm, and the minimum outer diameter of the valve after compression can reach 2.5–4.5 mm. Simultaneously, the overall length change during stent compression and expansion is minimal, greatly improving the smoothness of vascular delivery and the accuracy of valve implantation positioning. This meets the clinical needs of transcatheter aortic valve replacement surgery, enhancing the safety and effectiveness of artificial heart valve implantation.

To provide treatment for heart valve regurgitation, including mitral valve disease and tricuspid valve disease.SOLUTION: An annuloplasty ring includes elastic features that make the ring optimal for receiving a subsequent prosthetic valve via "Valve In Ring". The elastic features provide a squeezing force on the native valve annulus, which ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently placed prosthetic valve. In one embodiment, an annuloplasty ring comprises an elongate core having a shape configured to establish an optimal perimeter for a human blood valve when implanted in a circulatory system, and includes at least one elastic feature allowing the core to be stretched from a resting state to a stretched state, where the core is biased toward the resting state.SELECTED DRAWING: None

The utility model relates to the technical field of medical instruments, in particular to an artificial valve clamping piece and a conveying system. The artificial valve clamping piece comprises a clamping piece body, a connecting wire and a traction structure, the clamping piece body comprises a pipe body and a plurality of through holes formed in the pipe body, the pipe body is in a wave shape, and the two ends of the pipe body are closed to form a ring shape; the connecting wire penetrates into the tube body, and the end part of the connecting wire penetrates through the through hole in the tube body and then is suitable for being connected with the artificial valve; the traction structure comprises a traction wire, the traction wire is arranged in the pipe body in a penetrating mode through a through hole in the pipe body, and the traction wire is suitable for being connected with a conveying system. The clamping piece is of a periodic wave-shaped or fluctuating annular structure, can be fixed to the periphery of the outer surface of the artificial valve, can be radially compressed and expanded according to the size of the internal artificial valve, and is matched with the artificial valve to clamp the autologous valve leaflet, so that the artificial valve can be stably anchored at an accurate position without displacement, and meanwhile, the clamping piece can be used for clamping the autologous valve leaflet. The clamping device can reduce the occurrence risk of perivalvular leakage.

The present application relates to a kind of artificial heart valve stents and artificial heart valve.The artificial heart valve stent includes inner support and outer support.Inclination from inflow end to outflow end, first portion and second portion are included in sequence in inner support, the radial dimension of first portion is greater than the radial dimension of second portion, at least a portion of second portion is nested in outer support, and at least a portion of first portion extends to inflow end relative to outer support, and the portion of first portion extending to inflow end relative to outer support covers flow blocking film.The artificial heart valve includes the artificial heart valve stent and artificial valve leaflet fixedly connected in inner support.The artificial heart valve stent and artificial heart valve can reduce the risk of paravalvular leakage while being stably positioned in heart.

The present invention provides a valve stent and a usage method thereof for bicuspid aortic valve stenosis, comprising an ascending aorta contact area, a connecting body, a valve support area and a valve prosthesis suture part; the ascending aorta contact area is in an annular shape, a honeycomb-like structure formed by arranging and connecting a plurality of regular hexagons; the valve support area is in an elliptical annular shape, a grid structure formed by arranging and connecting a plurality of rhombuses. The present invention enhances the radial stiffness of the stent, thereby improving its radial support capacity; the valve support area is designed as an elliptical ring structure, and when implanting the artificial heart valve stent, the long-axis implantation angle of the valve stent is kept perpendicular to the long axis of the valve annulus, and by using the mutual coupling effect between the two, the cross-sectional shape of the expanded valve stent is finally circular, which improves the problem of poor expansion during the implantation of the valve stent and the elliptization after the valve stent is implanted, thereby reducing the occurrence of paravalvular leakage, with uniform stress and extended service life.

Provided are an artificial intelligence AI-based simulation device and method for supporting procedure planning in transcatheter aortic valve implantation. The device receives patient-specific medical images, such as computed tomography data, and generates a three-dimensional (3D) model of the aortic root and native valve. An artificial valve is virtually inserted into the 3D model, and the virtual implantation model is automatically converted into mesh data suitable for Computational Fluid Dynamics (CFD) and Fluid-Structure Interaction (FSI) analysis. The processor performs CFD / FSI simulations to evaluate hemodynamic changes, structural stresses, and potential device-tissue interactions. Based on the analysis, the system outputs predicted risks of procedure-related complications (including coronary obstruction, annular rupture, paravalvular leakage, and valve deformation) and provides guideline data for selecting valve size, implantation depth, and insertion angle. The disclosed device and method enable accurate, patient-specific prediction and visualization, thereby assisting clinicians in establishing safe and optimized TAVI procedure plans.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.