2547 results about "Biological tissue" patented technology

The present invention concerns a novel magnetic stimulation device and method with optimized energy usage and improved performance comprising: a magnetic field generating device, a first energy storage device and a second energy storage device connected in series to form an electrical oscillating resonant circuit; an energy source coupled to the first energy storage device; and a switch to allow charging of the first energy storage device from the energy source and initiating electrical oscillation of the resonant circuit, wherein after the initiation of the electrical oscillation the two energy storage devices repetitively exchange electric charge through the magnetic field generating device due to the electrical oscillation of the resonant circuit and a time varying magnetic field is generated. The time varying magnetic field induces electric currents in biological tissues that stimulate them.

The invention relates to an image segmentation method for a burn wound area, and the method comprises the steps: collecting burn wound images under different spectrums through a multispectral imaging device, and enabling the burn wound images to comprise a plurality of wavebands, namely visible light, infrared light and ultraviolet light; for each spectral image, analyzing reflection and absorption characteristics of a burn area under different wavebands by using optical characteristics of biological tissues, and marking a potential burn area; designing a self-adaptive algorithm, and dynamically adjusting parameters, including exposure and light intensity, of imaging equipment based on feedback of different spectral characteristics; the feature contrast of the burn area is enhanced; preliminarily delimiting the boundary of the burn region according to the enhanced spectral image through a threshold segmentation or region growing algorithm; inputting the multispectral image into a hierarchical processing model, and decomposing different tissue levels of the burn area including epidermis and dermis based on different wave band or color information; on each layering result, a feature extraction algorithm including texture analysis and edge detection is used for extracting detail features of each layer.

The invention relates to the technical field of database construction, in particular to a construction method and system for a reproductive medicine database. The method comprises the following steps: acquiring a biological tissue sample of a patient; acquiring reproductive endocrine hormone data, embryo morphological parameter data, immune cell function data and genome variation data from the biological tissue sample of the patient; performing time sequence analysis processing on the hormone fluctuation mode according to the reproductive endocrine hormone data to obtain endocrine dynamic characteristic data; performing image recognition processing based on coherent superposition characteristics of light on the embryo morphological parameter data, and performing embryo development potential evaluation to obtain embryo development potential data; and performing hierarchical clustering processing on the individual heterogeneity of the patient according to the immune cell function data and the genome variation data to obtain immune-genetic typing data of the patient. By means of the quantum dot sensing technology and the multi-channel micro-fluidic chip, standardization of data acquisition is achieved, and the heterogeneity problem of a data source is solved.

A robotic surgical system includes one or more robotic actuators configured to interact with biological tissue during a surgical procedure. A plurality of sensors include at least one of fiber Bragg grating sensors, piezoelectric strain sensors, or magnetostrictive sensors to capture real-time mechanical, elasticity, or deformation data from biological tissues. deep learning engine trained on a dataset comprising tissue mechanical responses across multiple tissue types, pathological states, and patient demographics. Pre-contact predictive adjustment profiles are generated for anticipated tissue interactions using preoperative imaging data registered to intraoperative coordinates. Intraoperative deviations are detected from predicted mechanical behavior and autonomously recalibrate actuator forces. Upcoming surgical maneuvers are anticipated based on prior task sequences and adjust actuator stiffness or damping properties in preparation for anticipated contact. An emergency override of actuator forces is provided via an anomaly detection module when real-time sensor data deviates beyond a threshold from the predicted safe mechanical response range. A feedback loop iteratively refines the deep learning engine during the procedure using supervised learning updates, anomaly detection, and reinforcement learning strategies. The reinforcement learning model is optionally shared across procedures to optimize distributed actuator force patterns for minimizing localized and cumulative tissue stress.

The invention discloses a surgical operating instrument and a surgical operating system. The surgical operating instrument comprises a handle assembly, a forceps head assembly and a forceps tube assembly. The handle assembly comprises a handle and a trigger, the forceps head assembly comprises a first forceps head and a second forceps head which can relatively pivot to realize opening or closing, and at least one of the first forceps head and the second forceps head is configured to be capable of treating biological tissues. The forceps tube assembly comprises a pull rod and a forceps tube, a second fluid channel is formed between the outer circumferential wall of the pull rod and the inner circumferential wall of the forceps tube, an opening communicated with the second fluid channel is formed in the position, close to the forceps head assembly, of the forceps tube, and the first fluid channel is communicated with the second fluid channel and used for being connected with a fluid conveying device. A fluid passage between the open hole and the fluid conveying device is achieved, instrument switching in the operation process is reduced, the operation efficiency is improved, the operation duration is shortened, and meanwhile the workload of doctors is reduced.

An interventional device for a tubular body, comprising: a stent switchable between a first state and a second state, the diameter of the stent in the second state being greater than the diameter of the stent in the first state; the at least one puncture part is arranged on the stent, and the puncture part is used for puncturing the wall of the tubular body when the stent is in the second state; the at least one electrode is arranged on the at least one puncture part, and the electrode is used for extending out of the tubular body from the area, punctured by the puncture part, of the wall. By means of the scheme, effective implantation of the electrode can be achieved based on the intervention device, the implanted electrode can make direct contact with the biological tissue target area outside the tubular body, direct and non-barrier signal interaction is achieved, and the signal collecting and stimulation applying effects of the electrode are greatly improved.

The invention provides a surgical process monitoring method and system based on machine vision, and the method comprises the steps: firstly obtaining a surgical scene real-time image sequence containing the dynamic images of a surgical instrument operation region and a biological tissue region; secondly, extracting a surgical instrument identification result (including an instrument type and a space posture) and a biological tissue segmentation result (including a tissue type and a region boundary), then monitoring an instrument operation track and a biological tissue region deformation parameter based on the results, generating a dynamic operation state parameter, and according to a predefined surgical stage safety threshold value, determining a biological tissue region deformation parameter; multi-modal anomaly detection is carried out on the dynamic operation state parameters, an abnormal event type and a risk level are determined, finally, a visual operation monitoring report is generated according to the abnormal event type and the risk level, the report covers abnormal area marks, risk prompt information and correction suggestions, comprehensive intelligent monitoring of the operation process is achieved, and the operation safety and the success rate are improved in an auxiliary mode.

An apparatus for generating currents in biological tissue is provided. The apparatus comprises an electrical source capable of generating an electric field across a region of tissue and means for altering the impedance of the tissue relative to the electric field, whereby an altered current is generated. The means for altering the impedance may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. The system can be used to provide stimulation safely and effectively in human transcranial use. The currents are used for stimulating tissues and treating diseases, such as for example Parkinson's Disease, Chronic Pain, Depression, and / or Opioid Use Disorder.

The present invention relates to a solution for assessing alterations in biological tissue in a non-invasive manner based on computer-implemented analysis of hyper and / or multispectral images of the biological tissue of interest. Alterations can be related to stresses, aging, pests, diseases, changes related to concentration of an active ingredient, and / or resistances against active ingredient, or the like as well as combination thereof. In a particular embodiment such alterations can be assigned to an alteration type and / or the degree of alteration can be quantified over time.

The invention discloses a photoacoustic imaging method and a photoacoustic imaging system, and the method comprises the steps: obtaining the ultrasonic image data of an imaging target, and determining the biological tissue type of the imaging target based on the features of the ultrasonic image data; a luminous flux distribution result corresponding to the biological tissue type is determined, and the luminous flux distribution result is generated after a simulation target tissue corresponding to the biological tissue type of the imaging target is irradiated by laser in the simulation imaging process of the simulation target tissue; the light source is used for representing luminous flux distribution conditions of biological tissues relative to the body surface under different imaging depths; obtaining photoacoustic image data of the imaging target; determining compensation parameters of the photoacoustic image data based on the luminous flux distribution result; compensating the photoacoustic image data based on the compensation parameter to obtain compensated photoacoustic image data; and generating a photoacoustic image according to the compensated photoacoustic image data. According to the invention, the quality and precision of the photoacoustic image can be improved.

The invention provides automatic dyeing equipment for biological tissue sample slices, which comprises a feeding mechanism, a feeding and discharging buffering mechanism, an automatic dyeing mechanism, a reagent adding mechanism, an after-dyeing drying mechanism, a reagent storage mechanism and a main console, the main console is in control connection with the feeding mechanism, the feeding and discharging buffering mechanism, the automatic dyeing mechanism, the reagent adding mechanism, the after-dyeing drying mechanism and the reagent storage mechanism, the feeding mechanism is provided with a plurality of microscope glass slide vertical placing supports, the automatic dyeing mechanism is provided with a dyeing groove, and the dyeing groove can be filled with a dyeing reagent and is matched with the microscope glass slides; the reagent adding mechanism can automatically add and supplement a dyeing reagent to the dyeing tank, the reagent storage mechanism can add and supplement the dyeing reagent to the reagent adding mechanism, and the post-dyeing drying mechanism is matched with the feeding and discharging temporary storage mechanism and the automatic dyeing mechanism. The microscope glass slide has the beneficial effect that the risk of cross contamination between microscope glass slides filled with biological tissue sample slices can be avoided.

This disclosure relates to a biological tissue forming method includes the following steps: providing a biological tissue forming package with a base, a membrane, a sliding assembly and a sealing film that seals a chamber of the base used for receiving the membrane and the sliding assembly with one of the base and the sealing film being light-transmitting; passing a biological tissue fluid through the sealing film and the sliding assembly so as to be dispensed on the membrane; moving the sliding assembly away from a covering position used for covering the membrane via at least one passive magnetic element so as to expose the biological tissue fluid on the membrane; and emitting the biological tissue fluid exposed on the membrane by a curing light transmitting through the one of the base and the sealing film so as to cure the biological tissue fluid into a biological tissue.

A linear response stretchable resistance strain sensor belongs to the technical field of wearable sensors, is of a three-layer film structure and comprises a stretchable elastic substrate, a middle strain sensitive layer and a stretchable elastic package on the uppermost layer. The nano conductive material network bonded by the trace polymer not only has high conductivity close to that of a pure nano conductive material, but also enhances the mechanical stability of the conductive network. Uniform and random cracks are formed after primary stretching, and a stable structure similar to a plane spring is formed. The strain of the measured object drives the size of the air gap in the crack to change, and the conductive path is changed, so that the resistance is changed. The invention shows the detection capability of the sensor in a strain range of 0.001% to 100%, hysteresis (1.61%), linear response, fast enough reaction speed and extremely low residual resistance. The strain sensor also has stability, pressure insensitivity and waterproofness, and is suitable for long-term accurate monitoring of strain of soft systems such as biological tissues in the field of medical health.

The invention provides an irreversible electroporation ablation effect evaluation method based on biological impedance analysis, and the method is characterized in that the method comprises the following steps: applying an electric signal to a to-be-ablated tissue; measuring a voltage across the subject tissue generated by the electrical signal; determining an impedance value across the subject tissue at a predetermined frequency based on the measured voltage; carrying out IRE ablation on the biological tissue, and repeating the previous steps to measure the impedance value of the tissue after ablation; and evaluating the irreversible electroporation ablation effect based on the impedance value across the tested tissue at the predetermined frequency and the impedance value of the tissue after ablation. The invention provides an irreversible electroporation ablation effect evaluation method for bioimpedance analysis. The method can evaluate the ablation effect of IRE and feed back IRE treatment.

A novel catheter is disclosed comprising an electrode array that is capable of switching between a sensing configuration for sensing electrical signals of biological tissue and an ablation configuration for delivery of ablation energy at a region of interest. Irrigation ports are interlaced within the electrode array to vent irrigant during an ablation procedure to; prevent excessive heating, charring of tissue, coagulation of blood, and allow for efficient delivery of ablation therapy for maximum therapy efficacy. The novel catheter includes a plurality of splines with linear portions wherein the electrodes of the electrode array are disposed. The splines are connected by connectors which include one or more bends capable of storing potential energy when the bends are elastically deformed, enabling collapse and expansion of the catheter in a sheath. Software logic associated with this catheter analyzes sensing signals to diagnose critical regions of the biological rhythm disorder, and enables directional guidance to move the catheter to critical regions for therapy.

A platform for characterizing biomolecules, biological tissue sections, viruses, or other particles of interest in a non-invasive, high-throughput, cost-effective, and label-free manner. The platform includes a merged set of imaging modalities including and capable of interferometric microscopy and wide-field or confocal microscopy (such as, for example, a wide-field super-resolution surface enhanced Raman spectroscopy, SERS), although some aspects may be employed with data sets only received from wide-field or confocal microscopy. Related devices, systems, methods, techniques, and variations to the same are also provided.

A novel catheter is disclosed comprising an electrode array that is capable of switching between a sensing configuration for sensing electrical signals of biological tissue and an ablation configuration for delivery of ablation energy at a region of interest. Irrigation ports are interlaced within the electrode array to vent irrigant during an ablation procedure to; prevent excessive heating, charring of tissue, coagulation of blood, and allow for efficient delivery of ablation therapy for maximum therapy efficacy. The novel catheter includes a plurality of splines with linear portions wherein the electrodes of the electrode array are disposed. The splines are connected by connectors which include one or more bends capable of storing potential energy when the bends are elastically deformed, enabling collapse and expansion of the catheter in a sheath. Software logic associated with this catheter analyzes sensing signals to diagnose critical regions of the biological rhythm disorder, and enables directional guidance to move the catheter to critical regions for therapy.

The invention relates to the technical field of biological tissue engineering, and discloses a nerve-blood brain barrier co-culture model, which comprises a culture chip, and nerves and blood brain barriers respectively constructed in upper culture micropores and lower culture micropores of the culture chip. Wherein a semi-permeable membrane is arranged between the lower-layer culture micropores and the upper-layer culture micropores of the culture chip; the nerves are obtained by inoculating neurons / brain organs obtained by stem cell differentiation into the upper culture micropores for co-culture, and the blood brain barrier is obtained by inoculating brain microvascular endothelial cells obtained by stem cell differentiation into one side of the semipermeable membrane in the lower culture micropores for co-culture. The co-culture model is higher in biomimetic property, and can better simulate the structure and function of the blood brain barrier, for example, the co-culture model has a barrier function closer to the physiological level, the selective permeability of a small molecule drug is matched with the in-vivo permeation condition, and the co-culture model has the function of a small molecule related transporter. The invention further discloses a construction method and application.

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

The invention discloses a multi-frame photoacoustic image reconstruction method based on optical flow alignment and depth feature fusion. The method comprises the following steps: S1, obtaining photoacoustic signal data; s2, reconstructing a photoacoustic cross-sectional image; s3, performing optical flow calculation and image alignment; and S4, training the deep feature fusion network. According to the method, through optical flow motion correction and a potential space learning mechanism, space-time information and complementary features in the aligned multiple frames of images are dynamically integrated, complementary information in the multiple frames of images is adaptively fused, noise is suppressed, and finally reconstruction of high signal-to-noise ratio and high spatial resolution images of biological tissues is achieved. Experimental results show that the method can significantly improve image quality, recover image distortion and detail loss caused by motion and noise, and provide a new effective scheme for promoting robust clinical application of a photoacoustic imaging technology.

The invention relates to the technical field of tumor detection, and discloses a tumor detection method and system and computer equipment, and the method comprises the following steps: obtaining autofluorescence decay data of a target biological tissue, and extracting fluorescence intensity and fluorescence lifetime data from the autofluorescence decay data; performing data fusion on the fluorescence lifetime data and the fluorescence intensity data of the target biological tissue to obtain dual-channel fusion data; and inputting the dual-channel fusion data into a tumor detection model pre-trained based on a deep learning network model, outputting the prediction probability of each pixel corresponding to different categories, taking the category with the highest probability value as the tumor detection result of each pixel, and obtaining the distribution positions of tumors and blood vessels in the target biological tissue. According to the method, the fluorescence lifetime data and the fluorescence intensity data are fused and then input into the tumor detection model, so that the model can analyze tissue characteristics from richer and more comprehensive dimensions, the distribution positions of tumors and blood vessels in target biological tissues can be more accurately positioned, and the detection accuracy and the recognition speed are improved.

The invention discloses an intelligent wearing health monitoring method and system based on biological impedance analysis, and relates to the technical field of biomedical engineering. The method comprises the following steps: constructing an original impedance spectrum of a biological tissue, and synchronously collecting an original impedance signal; a two-channel impedance model is constructed, and quantitative evaluation of the electrode contact quality is achieved; constructing a time-varying transfer function to obtain a de-noising impedance time-frequency signal; establishing a Cole impedance model, extracting characteristic parameters through a tensor decomposition method, and constructing a dynamic tissue parameter matrix; physiological feature vectors are generated through a multi-layer perceptron; constructing a metabolic impedance coupling differential equation to obtain a body component estimation vector, and realizing dynamic tissue parameter weight distribution and sensitivity adjustment; and carrying out grading evaluation on the calibrated body component vector. The stability and adaptability of the system are improved by optimizing impedance measurement, constructing a high-dimensional tissue parameter model, dynamically estimating body components, enhancing the interpretability of health assessment, cooperatively processing physiological state parameters and fusing multi-source information.

The invention relates to the technical field of medical monitoring, in particular to a wrist signal collecting and processing method and system based on biological tissue analysis. The system is used for generating wrist multi-signal acquisition optimization equipment by designing and integrating wrist wearable equipment corresponding to a photoelectric volume pulse wave sensor, an electrocardio sensor and a skin electric response sensor and performing position structure optimization design; the method comprises the following steps: acquiring PPG signals, ECG signals and GSR signals corresponding to wrist biological tissues in real time by using wrist multi-signal acquisition optimization equipment, and performing high-frequency drift preprocessing and biological tissue characteristic analysis to obtain a wrist biological tissue signal characteristic set; and performing feature redundancy and dimension reduction processing on the wrist biological tissue signal feature set, and performing wrist physiological state assessment analysis to obtain a wrist biological tissue state assessment result. According to the invention, accurate acquisition and analysis of wrist signals can be realized, so that reliable data support is provided for personalized analysis.

The invention relates to a three-dimensional spiral high-density neural electrode and a preparation method and application thereof. The three-dimensional spiral high-density neural electrode comprises a probe structure and a plurality of electrode sites. The probe structure is formed by curling a planar flexible electrode precursor, and at least one end of the probe structure is provided with a spiral outer surface of a three-dimensional spiral line structure. Electrode sites are distributed along a spiral path, have a size of 5-1000 [mu] m, and are used for contacting biological tissues. On the planar flexible electrode precursor, electrode sites are arranged on one or more straight lines forming an inclined angle alpha with the axial direction of the probe, and the spatial distribution is matched with the edge. Compared with the prior art, the method has the advantages that the constraint of a traditional wiring mode is broken through, the integration of high-density three-dimensional channels is realized under a micro size, and a new generation of solution is provided for a high-precision brain-computer interface, deep brain stimulation and a three-dimensional electroencephalogram.

The invention discloses a vascularized tissue culture chip as well as a construction method and application thereof, and belongs to the technical field of biological tissue engineering and biological medicines. The vascularization tissue culture chip is formed by stacking five layers of sub-chips with different function requirements, a fluid channel and a culture chamber are formed, a highly integrated system is formed, and the design of a micro-column array further optimizes the fluid dynamic characteristics and reduces the dead angle effect of fluid. In-vivo microcirculation can be simulated, and a stable and controllable nutrition and metabolite exchange environment is provided for skin and liver tissue. The vascularized tissue culture chip provided by the invention provides a powerful research platform for a plurality of biomedical research fields such as personalized medical treatment, disease modeling, drug screening, toxicity testing, disease model research and the like.

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

The invention discloses a spatial domain identification method and device based on multi-modal topological consistency, and belongs to the field of transcriptome spatial domain identification, and the method comprises the steps: constructing a multi-layer network which is in one-to-one correspondence with modal information contained in a biological tissue based on spatial transcriptomics data of the biological tissue; extracting a consensus structure feature shared by the multi-layer network and a specific structure feature specific to each layer of network; constructing a cell consistency network of the biological tissue according to the consensus structural features, the specific structural features and the multilayer network; and performing clustering processing on the cell consistency network to obtain recognition results of different spatial domains in the biological tissue. According to the method, the heterogeneity problem among different modal data can be overcome, and the spatial domain recognition effect is better.

Some disclosed methods involve monitoring a heart rate waveform associated with a subject to detect cardiac cycle markers, determining a cardiac phase transition window based on the cardiac cycle markers, and activating a photoacoustic sampling system at a start of the cardiac phase transition window, the photoacoustic sampling system including a piezoelectric receiver and a light source system. Such methods may involve, during the cardiac phase transition window, controlling the light source system to emit a plurality of light pulses into biological tissue of the subject, receiving, from the piezoelectric receiver, signals corresponding to acoustic waves emitted from portions of the biological tissue, and obtaining plethysmography data based on the signals. Such methods may involve deactivating the photoacoustic sampling system by an end of the cardiac phase transition window.