54 results about "Tissue membrane" patented technology

A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is constructed of a material that is destroyed upon forming the micropore. The transdermal drug delivery device also comprises at least one reservoir and a controller for controlling the formation of said micropore by the porator and destroying the porator after the formation of the micropore.

An organism tissue suturing apparatus for suturing a penetrated hole formed subcutaneously in a tissue membrane of an organism includes a body part having a predetermined length. The body part includes a rotary portion, disposed at a front end thereof, that can be inserted into the tissue of the organism from the hole, a needle member accommodated in a portion, inside the body part, rearward from the rotary position, and a pressing mechanism for advancing the needle member from a side surface of the body part and pressing the needle member into the rotary portion. The rotary portion has a needle member receiving portion for receiving essentially a front end of the needle member pressed into the rotary portion by the pressing mechanism, with the rotary portion disposed in the tissue of the organism. The needle member has a suturing thread of a duct for the suturing thread.

A titanium-mesh umbrella for bone grafting used to combine with conventional implant and to hold bone graft in proper position during dental implant placement procedure, comprises: a titanium metal shank with one end as implant end and the other end having a pin hole at its center to form a mounting portion; a titanium-mesh with its surface having a plurality of screen meshes, wherein said titanium-mesh encircles an area with a diameter in horizontal direction and forms a projecting umbrella surface with a curvature in perpendicular direction, a rough surface being formed on said projecting umbrella surface, said umbrella type titanium-mesh being able to position quickly on the mounting portion of said metal shank to form an umbrella structure. Thus, the titanium metal umbrella can be positioned quickly during dental implant placement procedure, so that the guide tissue membrane can be securely attached, a space for bone graft growing can be maintained, and the operation duration can be shortened.

The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.

A prosthetic valve implantable by catheter without surgery includes a frame with an abluminal surface extending between a proximal end of the frame and a distal end of the frame, and a single layer of a biocompatible membrane material mounted to the abluminal surface of the frame. The single layer of biocompatible membrane is located such that an interior surface of the membrane sheet extends between the proximal end of the frame and the distal end of the frame, and resides radially exterior the abluminal surface of the frame. In at least one embodiment, the disposition of membrane sheet at all points of attachment is entirely exterior/abluminal to the frame, such that no part of the abluminal surface of the membrane sheet contacts the frame.

The invention discloses a composite biological matrix for glaucoma surgery and a preparation method thereof. The composite biological matrix has a double-layer composite structure formed by aging and freeze-drying a compact base material layer and a loose layer coated on the compact base material layer, wherein the compact base material layer is a cross-linked denuded amniotic membrane or animal tissue membrane, and the loose layer is a porous membrane prepared from a biological macromolecular material. The composite biological matrix is prepared by multiple times of cross-linking modification, so that the retention time of the composite biological matrix in vivo is significantly prolonged, the effect of stably preventing scarring for a long term is achieved, and the long-term treatment effect after filtering surgery can be effectively improved.

A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane, tanning the membrane, coupling an active layer to an inner surface of the membrane, cutting the membrane into a desired shape and size, positioning the cut membrane onto a rod-shaped mold so that the cut membrane assumes a cylindrical configuration, and attaching a spiral support to the outer surface of the cut membrane.

The current invention discloses an apparatus for creating openings in tissue membranes and methods for using the apparatus. The apparatus comprises a cutting device that can include a cutting element and a resisting element located on the ends of elongate members. The cutting device can be manipulated so that the cutting element and resisting element are on opposite sides of the target tissue membrane. The cutting device is delivered to a tissue membrane using an elongate delivery device that can be routed through a working lumen in an endoscopic probe. The delivery device can also access the tissue membrane via means other than an endoscopic probe. Embodiments of the invention can include a vacuum lumen in the delivery device and a vacuum source for stabilizing the tissue membrane relative to the apparatus or for securing sections of tissue that are removed from the membrane.

A tool for forming a predetermined shaped and sized piece of tissue membrane from a sheet of surgically implantable tissue membrane comprising a body having a cutting portion configured to engage and to form a piece from a sheet of tissue membrane and a drive portion configured to apply a force to the cutting portion to form the piece of tissue membrane. The shapes and sizes of the cutting portions include those typically used in medical procedures.

The invention discloses a panax notoginseng loaded hemostatic tissue repair membrane. The panax notoginseng loaded hemostatic tissue repair membrane comprises a hemostatic layer and a tissue membrane repair layer, wherein the hemostatic layer is prepared by mixing panax notoginseng and/or dencichine with natural high polymer materials; the tissue membrane repair layer is prepared by performing electrostatic spinning on panax notoginseng and/or dencichine and an electrostatic spinning material for tissue repair; and in the tissue membrane repair layer, the panax notoginseng and/or dencichine accounts for 5-30 percent of the mass of the tissue membrane repair layer. The tissue repair membrane disclosed by the invention has a good hemostatic function, is conveniently operated by a doctor, realizes hemostasis, does not influence the original repair effect of the tissue repair membrane and is particularly suitable for repairing tissues of easily bleeding parts.

The invention a production method of MACA (mthe actualir conthe actual) candied fruits, which comprises the steps of cleaning and sterilizing digged fresh MACA, and sequentially carrying out low-temperature freezing, vacuum dehydration, vacuum impregnation, and the like on the MACA. After MACA is subjected to freezing treatment, cell tissue membranes of the MACA are damaged, so that the permeability of the MACA is increased, thereby facilitating the seepage of water in the process of unfreezing; and the texture of the tissue structure of the MACA subjected to freezing treatment is softer. Most of water in tissues of MACA is removed by vacuum dehydration, so that due to the reduction of the water, in the late production period of candied fruits, excessive water in the candied fruits is not required to be removed by using traditional high temperature roasting, thereby both saving energy and completely eradicating the damages caused by high temperature to nutritional ingredients and active substances in MACA. The vacuum impregnation is low in temperature and rapid in speed, so that the original color and flavor of MACA are retained, and because the whole impregnation process is performed in a closed state, the safety and wholesomeness of food are ensured.

The invention relates to a preparation method for a decellularized tissue membrane. The method comprises the following steps: 1) removing adipose tissue on the tissue membrane, washing and cleaning bloodstain; 2) placing the neutralized and washed tissue in surfactant solution and soaking, and adequately removing impure proteins; 3) placing in protein renaturation solution and soaking; 4) placing in an organic solvent and soaking, and separating out grease; 5) placing in alkaline solution and soaking, neutralizing, and preparing pores on the tissue membrane; 6) placing the tissue membrane in solution containing a crosslinking agent and soaking, crosslinking; and 7) executing the radiation sterilization to the tissue membrane obtained in the steps in the wet state; or executing the radiation sterilization or EO sterilization in the freeze-drying mode. The method is capable of removing antigens, such as cells, lipids and impure proteins, in the human source or animal source tissue membrane, keeping and extracellular matrix and generating the suitable pores. The prepared decellularized tissue membrane can be used as a tissue engineering bent, a patching material for tissue membrane damage and a wound surface dressing.

The invention relates to an oral cavity defect repair membrane and a preparation method thereof, in particular to an acellular matrix material and preparation thereof, and the application in the repair of oral cavity defect. The preparation comprises: (1) taking the porcine small intestine jejunum segment, cleaning, radial cutting, removing the mucosa layer, sarcolemma layer and serosa layer, andobtaining the porcine small intestine submucosa tissue membrane; (2) soaking the tissue membrane of the porcine small intestine submucosa obtained in the step (1) in peroxyacetic acid solution or sodium hydroxide solution, and take out and cleaning to obtain an acellular matrix of the porcine small intestine submucosa tissue; (3) soaking the porcine small intestinal submucosa tissue obtained in the step (2) with a dopamine solution, sterilize, and obtaining an acellular matrix material. The invention can avoid the loss of cell growth factor in the tissue membrane of the porcine small intestinesubmucosa, ensure the the obtained acellular matrix material has better tissue micropore structure and mechanical properties, and can meet the needs of oral bone injury repair; low immunogenicity andgood safety.

The invention belongs to the technical field of biological analysis and detection and in particular relates to an integrated device for gathering, purifying and enzymolyzing membrane protein in online identification of the membrane protein. The device consists of a high-pressure pump, a six-way valve, a membrane protein covalent fixation reaction column and relevant connection structures, wherein active groups on the surface of filler in the membrane protein fixation reaction column can react with dissociated amino and carboxyl of the membrane protein so as to firmly fix the membrane protein in the reaction column. By using a covalent bonding principle, the membrane protein is fixed in the reaction column; interference materials such as solubilizers and phospholipid can be removed by using a method for washing mobile phase on line, so that extra sample loss is avoided, and the ideal identification effect is achieved. Experiments show that the device has the advantages of high reaction efficiency and small nonspecific adsorption and can be successfully applied to the identification of rat liver tissue membrane protein groups. The device is novel in structure, practical and efficient and has popularization and application prospects.

A structurally enhanced tissue graft has at least one placental membrane having a corrugated portion made of a series of pleated peaks and valleys. The structurally enhanced tissue graft further may have one or both of a first and second flat portion tissue membrane adhered to the corrugated portion. The first flat portion is adhered to an external surface along either peaks or valleys of the corrugated portion. The second flat portion tissue membrane adhered to the corrugated external surface along the corrugated portion opposing peaks or valleys. The first flat portion forms a top or bottom of the structurally enhanced tissue graft and the second flat portion forms an opposing bottom or top with the corrugated portion sandwiched therebetween.

The invention discloses a frozen fat eliminating device. The frozen fat eliminating device comprises a fat eliminating instrument and a glycerin wet tissue membrane paste assorted with the fat eliminating instrument, wherein the glycerin wet tissue membrane paste acts on the skin of an object so as to form an interface in a treatment area; the fat eliminating instrument comprises a heat-conducting fin and a semiconductor refrigeration chip which are arranged in an instrument shell; the refrigeration temperature is transferred to the heat-conducting fin by a working area of the semiconductor refrigeration chip through a control circuit, and the skin is frozen by the heat-conducting fin through the glycerin wet tissue membrane paste; the glycerin wet tissue membrane paste comprises non-woven fabric, pure water, glycerin and preservative. According to the frozen fat eliminating device, the low temperature generated through refrigeration of the semiconductor refrigeration chip and a glycerin wet tissue together act on the skin, which needs treatment, metabolism of a human body is accelerated, so that water molecules of subcutaneous fat are crystallized and are finally congealed, thus a fat layer is gradually decreased to achieve the purpose of spot reduction; the frozen fat eliminating device has the advantages of no pain, no side effect, convenience for use, low price, quick weight loss and convenience for carrying.

A shaped transplant product 10 derived from human umbilical cord 2 has a collagenous tissue membrane 20 derived from an umbilical cord 2 made essentially of thick collagenous tissue which is shaped to form a soft tissue barrier or wound covering or other internal or external wound healing attachment. The shaped transplant product 10S has a defined memory shape that can be configured to pass through a hollow cylindrical trocar or arthroscopy device for implantation. The defined memory shape can be a hollow elongated split tube. The split tube along the split can have abutting edges. The split tube can have an open split forming a gap between edges adjacent the open slit. The split tube can have overlapping edges. The split tube can have an elongated body having a center portion tapering toward opposing smaller ends to form a pre-set shape.

The invention relates to a biological periosteum repair material and a preparation method thereof, and particularly relates to an acellular dermis matrix material and a preparation method and application thereof to periosteum repair. The preparation method comprises: (1) taking a jejunum segment of a pig small intestine, cleaning up, radially cutting open, removing a mucous layer, a myolemma layerand a serosal layer and obtaining a pig small-intestine mucous lower-layer tissue membrane; (2) sequentially carrying out the following processing on the obtained pig small-intestine mucous lower-layer tissue membrane: firstly, placing in peracetic acid solution to soak and cleaning up; then placing in sodium hydroxide solution to soak and cleaning up; finally, placing in acetone solution to soak, cleaning and obtaining a pig small-intestine mucous lower-layer tissue acellular matrix. The biological periosteum repair material is high in biological safety, low in immunogenicity and cytotoxicity, good in biocompatibility, can promote multiplication of cells adhered to the biological periosteum repair material, is applicable to use as a biological repair material and is particularly suitablefor periosteum repair.

The invention discloses a tissue scaffold based sodium ion channel detection method of three dimensional optic cup originated neuron-like cells. According to the method, the nerve fiber layer of human iPSc source 3D retina is digested into single cells; then the single cells are taken as the seed cells, after induced differentiation and culture medium re-suspension, the seed cells are inoculated to a matrix gel embedded polylactic acid-hydroxyacetic acid polymer scaffold, then the seed cells are cultured in an induced differentiation culture medium, which is composed of a neurotrophic factor containing retina differentiation nutrient liquid with a constant concentration; and after the culture lasts for a while, the neuron-like cells on the polylactic acid-hydroxyacetic acid polymer scaffold are subjected to sodium ion channel detection to detect the neurological basic functions of the neuron-like cells. The nerve cells cultured on the PLGA membrane is subjected to sodium ion channel immuno-fluorescent staining; the state of cells on the tissue membrane can be represented more realistically; and reference and basis are provided for the membrane clamp detection on functional potential of cells on the membrane.

The invention belongs to the technical field of tissue membranes. A high-barrier double-sided heat-sealable tissue membrane is characterized by consisting of a heat sealing layer, a first core layer, a second core layer and a corona layer which are sequentially arranged in a curtain-coated four-layer co-extrusion mode, wherein the mass percentages of the heat sealing layer, the first core layer, the second core layer and the corona layer are respectively 20%, 31%, 31% and 18%; the heat sealing layer is composed of the following raw materials in percentage by mass: 25% of a binary copolymer, 47.5-48% of a ternary copolymer, 24%-24.5% of a homopolymerization material, 0.5%-1% of an antistatic agent and 2%-2.5% of a slipping agent; and the corona layer is made from a binary copolymer or a ternary copolymer. The tissue membrane disclosed by the invention can be subjected to double-sided heat-sealing, and can conform to different heat sealing modes (applicable to the packaging of different paper products) of paper products.