Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane

Abstract

A prosthetic valve implantable by catheter without surgery includes a frame with an abluminal surface extending between a proximal end of the frame and a distal end of the frame, and a single layer of a biocompatible membrane material mounted to the abluminal surface of the frame. The single layer of biocompatible membrane is located such that an interior surface of the membrane sheet extends between the proximal end of the frame and the distal end of the frame, and resides radially exterior the abluminal surface of the frame. In at least one embodiment, the disposition of membrane sheet at all points of attachment is entirely exterior / abluminal to the frame, such that no part of the abluminal surface of the membrane sheet contacts the frame.

Description

technical field [0001] The present invention relates to the field of medical devices, and more particularly to percutaneously deliverable heart valves and percutaneously deliverable vascular valves. Background technique [0002] Heart valve disease is a common degenerative disorder that impairs physiological function and causes restrictive symptoms and is life-threatening for millions of patients worldwide. There are multiple underlying causes, but heart valve dysfunction ultimately manifests as insufficient conduction of blood through the plane of the valve due to narrowing (stenosis) of the anatomical pathway, or as an insufficiency that allows blood to return through the valve again, thereby reducing Efficient forward conduction of blood through a valve (incompetent or backflow of blood). These hemodynamic states result in 1) inadequate cardiac output and 2) an unfavorable load on the heart's pumping chambers, both of which in turn lead to patient dysfunction and often p...

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