Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane

Abstract

A prosthetic valve implantable by catheter without surgery includes a frame with an abluminal surface extending between a proximal end of the frame and a distal end of the frame, and a single layer of a biocompatible membrane material mounted to the abluminal surface of the frame. The single layer of biocompatible membrane is located such that an interior surface of the membrane sheet extends between the proximal end of the frame and the distal end of the frame, and resides radially exterior the abluminal surface of the frame. In at least one embodiment, the disposition of membrane sheet at all points of attachment is entirely exterior/abluminal to the frame, such that no part of the abluminal surface of the membrane sheet contacts the frame.

Description

technical field [0001] The present invention relates to the field of medical devices, and more particularly to percutaneously deliverable heart valves and percutaneously deliverable vascular valves. Background technique [0002] Heart valve disease is a common degenerative disorder that impairs physiological function and causes restrictive symptoms and is life-threatening for millions of patients worldwide. There are multiple underlying causes, but heart valve dysfunction ultimately manifests as insufficient conduction of blood through the plane of the valve due to narrowing (stenosis) of the anatomical pathway, or as an insufficiency that allows blood to return through the valve again, thereby reducing Efficient forward conduction of blood through a valve (incompetent or backflow of blood). These hemodynamic states result in 1) inadequate cardiac output and 2) an unfavorable load on the heart's pumping chambers, both of which in turn lead to patient dysfunction and often p...

AI Technical Summary

Problems solved by technology

[0007] Second, the PHV must, in its implanted working configuration, mimic both the open and closed operation of a natural heart valve—two different geometries and mechanical structures such as those provided by the natural anatomy of the aortic valve, but there are The limitation is that the PHV must be effectively contained within its physical and working capsule without the advantage of the very different anatomy of the native aortic valve

That is, while Hill at paragraph [0072] generally discusses the use of various possible fasteners to attach the cover to the frame, none of the fasteners are shown and described with respect to the frame

Of particular importance is that while Hill mentions coupling the cover 108 to the frame 102 at the connection areas 132 and 134, there is no mention of coupling the cover 108 to the frame member 126 leading to the connection areas 132 and 134. arch of

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