28 results about "Cardiac output" patented technology

Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. Based on the received signals, the progress of contraction of the heart is determined. Based on the progress of contraction, the chamber of the heart may then be stimulated at a plurality of locations. In another embodiment, a plurality of electrodes are implanted in the left ventricle to stimulate at multiple locations in the left ventricle for the purpose of improving hemodynamic performance and increasing cardiac output in a patient who is suffering from congestive heart failure.

Systems and apparatus are provided for using a non-invasively monitored uncalibrated pressure signal from a patient to compute cardiac output and other cardio-vascular parameters, thereby providing safe, effective, reliable and low cost monitoring of patient health. Wearable devices are disclosed that include a sensor array for obtaining patient data that is used to provide an estimate of aortic systolic blood pressure, cardiac output, and end-systolic elastance that may be determined without the need for a cuff.

The invention relates to the technical field of vital sign monitoring, and discloses a non-invasive vital sign monitoring system and method.The system comprises a basic vital sign monitoring module, an extended vital sign monitoring module, a hemodynamic monitoring module and a monitoring and early warning module; the basic vital sign monitoring module is used for monitoring breathing related indexes and stress indexes; an oxyhemoglobin saturation monitoring unit of the extended vital sign monitoring module is used for acquiring a PPG signal through a photoelectric volume sensor and monitoring oxyhemoglobin saturation according to the PPG signal; the hemodynamics monitoring module is used for carrying out cuff-free blood pressure monitoring on the basis of pulse transmission time delay and monitoring output quantity per stroke and cardiac output quantity according to the electrocardiogram signal, the PPG signal and the pulse transmission time delay; and the monitoring and early warning module is used for determining the comprehensive health index of the patient according to the monitoring data of the basic vital sign monitoring module, the extended vital sign monitoring module and the hemodynamics monitoring module, and carrying out prediction and early warning on the physiological state of the patient.

A system for determining a global hypoperfusion index (GHI) includes an arterial blood pressure sensor, a ventricular blood pressure sensor, an oximetry module, and an integrated hardware unit including a system processor and a system memory. The system memory includes instructions that cause the system to receive arterial hemodynamic data, ventricular hemodynamic data, and blood oxygen saturation data. One or more right ventricular pressure features, one or more pulmonary artery pressure features, one or more cardiac output parameters, and one or more venous oxygen saturation parameters are derived from the arterial hemodynamic data, the ventricular hemodynamic data, and the blood oxygen saturation data. The GHI is derived by using a predictive decision model based upon the one or more right ventricular pressure features, the one or more pulmonary artery features, the one or more cardiac output parameters, and the one or more venous oxygen saturation parameters.

The present application relates to the technical field of medical image monitoring, in particular to an intraoperative cerebral oxygen saturation image dynamic monitoring and early warning system and method for elderly patients, comprising a bilateral cerebral oxygen acquisition module, a cerebral oxygen waveform image construction module, a cerebral oxygen image feature extraction module, a hierarchical early warning module and a multi-parameter linkage display module, through the bilateral cerebral oxygen saturation time series signals output by the bilateral near-infrared cerebral oxygen saturation sensors are synthesized into a double-channel cerebral oxygen waveform image aligned with the same time window start and end time and sharing the amplitude scale, three types of geometric morphological features of bilateral cerebral oxygen slope, bilateral cerebral oxygen asymmetry index and relative baseline drop amplitude are uniformly extracted in the image domain, three types of high-risk mode hierarchical triggering of unilateral cerebral oxygen threshold persistence, relative baseline drop and bilateral asymmetry are driven, and the invasive arterial pressure, cardiac output, anesthesia depth index waveform and hemodynamic event characteristic root cause pairing display are jointly presented.

The application discloses a non-invasive continuous real-time blood pressure and hemodynamics and heart function integrated device and a data calculation method thereof, which comprises a signal acquisition module, a statistical and weighted calculation module, a communication module and a display module which are electrically connected with a main control board, wherein the signal acquisition module comprises an ECG and heart sound digitization detection module and a real-time continuous blood pressure and hemodynamics calculation module.The application has the beneficial effects that: the device combines the heart sound and ECG with the non-invasive hemodynamics acquisition device, and the blood pressure parameters obtained by the device are mutually calibrated, so that the device not only solves the problems of real-time continuous blood pressure and hemodynamics detection, but also synchronously outputs ECG parameters, heart sound logarithms, cardiac output, stroke volume, vascular resistance, cardiac contractility and other parameters.

The present invention relates to a device, system and method for monitoring of peripheral arterial perfusion of a subject. To enable distinguishing between low pulsatility caused by centralization or low cardiac output, the proposed device comprises an input (30) for receiving first detection data of a tissue region of a subject, said first detection data being acquired over time by detecting radiation reflected from and / or transmitted through tissue of the subject, and for receiving second detection data of a skin region of subject, said second detection data being acquired over time by detecting radiation received from said tissue region in response to coherent light being emitted towards said skin region, a PPG unit (32) for deriving a photoplethysmography, PPG, signal from said first detection data, a flow unit (34) for deriving, from said second detection data, a flow signal indicative of a flow of light scattering particles within the skin region, and an evaluation unit (36) for evaluating said PPG signal and said flow signal to obtain information on the peripheral arterial perfusion, wherein the evaluation unit is adapted to determine a state of low vascular compliance and / or a state of low cardiac output based on a combined evaluation of said PPG signal and said flow signal.

The invention belongs to the technical field of medical instruments, and provides a control module and device for dynamic blood flow regulation of a left ventricular assist device.A processor in the control module circularly executes the steps that motion data, the current heart rate and the current blood pressure of a patient and the actual blood flow in a blood pump blood flow channel are obtained; extracting motion features from the motion data of the patient, and inputting the motion features to a motion classification model to obtain a motion mode; determining a motion intensity index of the patient based on the motion pattern and the current heart rate; using a first flow model to obtain a basic blood flow based on the exercise intensity index of the patient; obtaining a target blood flow based on the current heart rate, the current blood pressure and the basic blood flow of the patient by using a flow correction model; and determining a target driving current of a stator coil of the blood pump based on the actual blood flow and the target blood flow by adopting a preset control algorithm. The pump speed is automatically adjusted according to the activity state (such as movement and sleep) of the patient, so that cardiac output supports adaptation to the patient.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit, such as veno-venous extracorporeal membrane oxygenation, includes determining (i) a first arterial carbon dioxide content or surrogate and (ii) a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; establishing a second removal rate of carbon dioxide from the blood in the oxygenator in the extracorporeal blood oxygenation circuit; determining (i) a second arterial carbon dioxide content or surrogate and (ii) a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood; and calculating a cardiac output of the patient corresponding to a blood flow rate through the extracorporeal blood oxygenation circuit, the first arterial carbon dioxide content or surrogate, the first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; the second arterial carbon dioxide content or surrogate and the second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood.

The application provides a kind of ventricular assist device control device, method, ventricular assist system and electronic equipment, it is related to the field of medical instrument control.The control device includes: timing judgment module, characteristic flow calculation module and motor control module;Timing judgment module is used to divide target cardiac cycle into systolic phase and diastolic phase;Characteristic flow calculation module is used to divide the real-time flow of ventricular assist device in target cardiac cycle into systolic flow in systolic phase and / or diastolic flow in diastolic phase, and calculate the characteristic cardiac output of ventricular assist device in target cardiac cycle according to systolic flow and diastolic flow;Motor control module is used to adjust motor speed.Using the control device provided by the embodiment of the application can make the cardiac output of ventricular assist device more in line with the physiological law of heart, realize the stable control of cardiac output.

The invention relates to the technical field of medical monitoring, in particular to a post-anesthesia multi-mode heart blood supply monitoring system and a post-anesthesia multi-mode heart blood supply monitoring method which are used for solving the problems that existing post-anesthesia heart blood supply monitoring is single in mode, low in accuracy, lagged in intervention and the like. The system comprises a multi-mode sensing module, a data preprocessing module, a fusion analysis module, a display early warning module and a feedback regulation module which are electrically connected in sequence, multi-source signals such as myocardial blood oxygen and cardiac output are collected through multiple sensors, through ANC algorithm and Butterworth filtering preprocessing, a CNN-LSTM model is used for fusion analysis and early warning grade division, and the early warning system is used for early warning. And the feedback module is linked with the drug delivery system to realize graded automatic intervention. The method comprises seven steps of preoperative preparation, signal acquisition, preprocessing, fusion analysis, display early warning, feedback intervention and postoperative monitoring, and personalized monitoring is realized in combination with a preoperative baseline. According to the invention, non-invasive, real-time and accurate monitoring is realized, the anomaly detection accuracy is high, a monitoring-intervention closed loop is formed, the occurrence rate of postoperative cardiac complications is reduced, and the intelligence and safety of post-anesthesia nursing are improved.

Methods and systems are disclosed for creating and using a neural network model to estimate a cardiac parameter of a patient, and using the estimated parameter in providing blood pump support to improve patient cardiac performance and heart health. Particular adaptations include adjusting blood pump parameters and determining whether and how to increase or decrease support, or wean the patient from the blood pump altogether. The model is created based on neural network processing of data from a first patient set and includes measured hemodynamic and pump parameters compared to a cardiac parameter measured in situ, for example the left ventricular volume measured by millar (in animals) or inca (in human) catheter. After development of a model based on the first set of patients, the model is applied to a patient in a second set to estimate the cardiac parameter without use of an additional catheter or direct measurement.

The disclosed concepts are directed to providing protocols, ideas, concepts, designs, methods and systems related to determining vascular compliance of a subject. In particular, blood pressure and arterial flow of first and second arteries (corresponding arteries on the same or contralateral limb) are measured (e.g., as a function of arterial diameter and / or velocity at which blood travels through the arteries). The pulse pressure can be determined from the blood pressure and the pulse quantity can be determined from the arterial flow. Vascular compliance can be determined from the pulse pressure and the volumetric pressure. Therefore, a direct and accurate vascular compliance estimation result can be obtained in a non-invasive manner. Also disclosed is using the determined vascular compliance in a transfer function to obtain accurate hemodynamic parameter estimates (e.g., cardiac output and stroke output) of a subject.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit includes measuring first oxygenated blood flow rate by a pump in the extracorporeal circuit and a corresponding arterial oxygen saturation and recirculation in the extracorporeal circuit, then changing the pump flow rate, such as decreased, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances or drift), which change in the arterial oxygen saturation and recirculation are measured. From the first flow rate and the second flow rate along with the corresponding measured recirculation and the arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation. The system also includes an accommodation of oxygenation by the lungs of the patient during the extracorporeal blood oxygenation.

The invention relates to a computer-implemented method for determining a cardiovascular performance (2). The method comprises receiving a plurality of measurement data (5) through a communication interface (6) from a sensor (7) at a measurement section (41) of the patient's distal periphery (4). The measurement data (5) provides information about a perfusion of the blood flow at the measurement section (41). The plurality of measurement data (5) comprises at least two different measurement data (5) detected at different times after the blood flow to the distal periphery (4) has been restored. The method further comprises determining the cardiovascular performance (2), in particular the cardiac output, based on the plurality of measurement data and providing output data by an output interface (8) comprising the cardiovascular performance (2).

The invention relates to a device (105) for determining a cardiac output for a cardiac assist system (100), wherein the device (105) comprises a support structure (115) and a sensor device (120). The support structure (115) comprises at least one brace (125) and a connection section (130) for connecting the device (105) to an element (110, 112) of the cardiac assist system (100). The at least one brace (125) is connected to the connection section (130) and can be folded away from the element (110, 112). The sensor device (120) is coupled to the at least one brace (125) and configured to sense a blood stream.

This invention discloses a parameter identification method for a lumped parameter model of systemic circulation, belonging to the field of lumped parameter model technology. The method includes: constructing the state equation of the lumped parameter model of systemic circulation based on Kirchhoff's voltage and current laws to obtain the systemic circulation control equation; calculating the duration ratio of systolic to diastolic phases and stroke volume based on routine clinical measurement data, constructing classic aortic pressure and flow waveforms, and performing registration processing; calculating central venous pressure and flow based on routine clinical measurement data; and using the registered aortic inlet pressure and flow, central venous pressure and flow, and systemic circulation control equations to calculate the values ​​of each parameter in the parameter model. This invention, by periodically stretching the classic reference waveform, matches the waveform extreme values ​​with the patient's measured blood pressure and cardiac output, indirectly reconstructing the aortic inlet pressure and flow curve reflecting individual characteristics under non-invasive conditions, significantly improving the model's individualization and clinical compatibility.

The application discloses a kind of applied to the monitoring method, system and electronic equipment of perioperative patient, the system includes: wearable information acquisition device and risk prediction device, wherein, risk prediction device includes: user physiological information acquisition unit, for obtaining user physiological information by wearable information acquisition device, physiological information includes: electrocardiogram information, pulse wave information, blood vessel information;User comprehensive physiological information generation unit is used to generate user comprehensive physiological information based on predetermined algorithm according to physiological information, comprehensive physiological information includes: blood pressure information, cardiac output information;Prediction unit is used to input comprehensive physiological information into pre-trained multi-modal illness classification model, and obtain the user potential risk information output by model, multi-modal illness classification model is based on stack method to analyze comprehensive physiological information;Risk information sending unit is used to send user potential risk information to monitoring center.

The application discloses a kind of based on blood pressure waveform cardiac output estimation method and system.The method comprises: obtaining the initial blood pressure waveform information of current cycle;The initial blood pressure waveform information of current cycle is extracted, to obtain the waveform feature information of current cycle;By regression model, according to waveform feature information, generate the initial stroke volume of current cycle;By last cycle regression model coefficient, the initial stroke volume is calibrated, to obtain the calibrated vascular impedance and the corrected stroke volume of current cycle;According to the corrected stroke volume of current cycle, generate the cardiac output of current cycle.The application is through advanced waveform preprocessing, dynamic feature extraction and adaptive calibration, not only can realize continuous, non-invasive cardiac output estimation, can also compensate interference under noise and variation environment stably, provides efficient, reliable technical approach for cardiac function monitoring.

Foley type catheter embodiments for sensing physiologic data from a urinary tract of a patient are disclosed. The system includes the catheter and a data processing apparatus and methods for sensing physiologic data from the urinary tract. Embodiments may also include a pressure sensor having a pressure interface at a distal end of the catheter, a pressure transducer at a proximal end, and a fluid column disposed between the pressure interface and transducer. When the distal end is residing in the bladder, the pressure transducer can transduce pressure impinging on it into a chronological pressure profile, which can be processed by the data processing apparatus into one or more distinct physiologic pressure profiles, for example, peritoneal pressure, respiratory rate, and cardiac rate. At a sufficiently high data-sampling rate, these physiologic data may further include relative pulmonary tidal volume, cardiac output, relative cardiac output, and absolute cardiac stroke volume.

The present application relates to a kind of improving vascular senility composition and its preparation method and application, belong to natural product technical field.The present application provides a kind of improving vascular senility composition, including osmanthus fragrans extract and pumpkin seed protein peptide, the mass ratio of osmanthus fragrans extract and pumpkin seed protein peptide is osmanthus fragrans extract:pumpkin seed protein peptide=1:(0.2-8).The present application is improved vascular senility composition by osmanthus fragrans extract and pumpkin seed protein peptide collocation, can effectively inhibit angiotensin II induced vasoconstriction, enhance cardiac output, prevent zebra fish heart structure and function damage, while also can enhance blood flow velocity, reduce vascular injury, from multidimensional synergistic prevention vascular senility formation.

A system for determining a global perfusion insufficiency index (GHI) includes an arterial blood pressure sensor, a ventricular blood pressure sensor, an oximetry module, and an integrated hardware unit including a system processor and a system memory. The system memory includes instructions that cause the system to receive arterial hemodynamic data, ventricular hemodynamic data, and oxyhemoglobin saturation data. One or more right ventricular pressure characteristics, one or more pulmonary arterial pressure characteristics, one or more cardiac output parameters, and one or more venous blood oxygen saturation parameters are derived from arterial hemodynamic data, ventricular hemodynamic data, and blood oxygen saturation data. GHI is derived using a predictive decision model based on one or more right ventricular pressure characteristics, one or more pulmonary artery characteristics, one or more cardiac output parameters, and one or more venous oxygen saturation parameters.

This invention discloses a traditional Chinese medicine composition for treating heart failure and insufficient cardiac function, belonging to the field of pet medicine technology. The composition, based on a 30 kg pet, is made from the following raw materials in parts by weight: ginseng 5-7g, astragalus 18-22g, salvia miltiorrhiza 8-12g, lepidium seed 4-6g, aconite root 1-3g, alisma 8-12g, poria cocos 8-12g, polygonatum odoratum 4-6g, cinnamon twig 2-4g, chuanxiong rhizome 1-3g, coptis chinensis root 1-3g, and licorice root 2-4g. This composition follows the principles of invigorating qi and warming yang, promoting blood circulation and removing blood stasis, and promoting diuresis and reducing swelling. It can effectively improve heart failure, insufficient cardiac function, and insufficient cardiac output in pets, increase left ventricular ejection fraction and cardiac output, and reduce myocardial damage indicators. It has definite clinical efficacy, high safety, and few toxic side effects, is suitable for the physiological characteristics of dogs, cats, and other pets, and has a simple preparation process, making it suitable for widespread clinical application in pets.

The invention discloses radix ophiopogonis powder capable of improving mitochondrial activity and resisting aging and a preparation method and application of the radix ophiopogonis powder, and relates to the technical field of radix ophiopogonis products. The prepared radix ophiopogonis powder can effectively improve mitochondrial membrane potential, activate a mitochondrial compound I, increase ATP (adenosine triphosphate) generation and reduce ROS (reactive oxygen species) level, remarkably recover heart beat output and realize cross-model mitochondrial activation in a zebra fish myocardial injury model, and can remarkably improve activity of a nematode compound I, nematode movement ability and nematode life in a nematode model. Meanwhile, the compound has good safety in a human body, and can improve mitochondrial activity and delay telomere shortening after being orally taken. The composition is used for human skin, has excellent moisturizing, barrier repairing and anti-oxidation effects, and has the functions of remarkably improving mitochondrial activity and resisting aging.

A system and method for prolonged organ preservation and real-time ex-vivo organ assessment. The organ perfusion and assessment system includes three components: A full cardiac output circuit, a resuscitation and low flow circuit, and an organ indexing stack to perform real-time hemodynamic ex-vivo organ assessment. A containment vessel maintains sterility and allows for complete echo-analysis. The slope of preload recruitable stroke work (PRSW) and other load-independent and load-dependent assays are used to stratify donor heart function. The best assessment of systolic function and therefore transplant suitability appears to be PRSW; the best systolic function is seen with full support of a donor heart. The best assessment of diastolic dysfunction appears to be Tau; the best diastolic function is also seen with full support of a donor organ. Load independent assessments appear to be highly repeatable and should identify currently discarded human donor hearts that are actually suitable for transplantation.

A system for determining a patient's hemodynamic state includes a first hemodynamic sensor and a display. The first hemodynamic sensor generates a first hemodynamic sensor signal representing the patient's right ventricular pressure waveform. The system further includes one or more processors and a computer-readable memory in which instructions, when executed by one or more processors, cause the system to receive the first hemodynamic sensor signal, convert the right ventricular pressure waveform into an estimate of the blood flow waveform, and extract features from the right ventricular pressure waveform. The instructions further cause the system to estimate the patient's cardiac output based on the right ventricular pressure waveform or features extracted from the patient's right ventricular pressure waveform, and to output the blood flow waveform and cardiac output to the display.

The utility model provides an adjustable in-aorta balloon catheter, which relates to the technical field of balloon catheters and comprises a main balloon, a control balloon and a catheter, an air passage is arranged in the catheter, and the main balloon and the control balloon are distributed along the axial direction of the catheter. The control balloons are distributed at the near end and / or the far end of the main balloon in the axial direction of the catheter, the main balloon and the control balloons are both communicated with the air channel and are configured to be independently inflated and deflated through the air channel, and when the main balloon and the control balloons are both in a full state, the diameter of the control balloons is larger than that of the main balloon. The adjustable balloon catheter in the aorta can solve the problems that a traditional balloon catheter is limited in cardiac displacement, low in systemic circulation perfusion amount and the like.

The present invention relates to a method for producing a cell spheroid through co-culture of adipocytes and cardiomyocytes, a cell spheroid produced thereby, and use thereof. Upon administration of the cell spheroid produced through co-culture of adipocytes and cardiomyocytes, of the present invention, the cell spheroid has the effects of improving the functions of cardiomyocytes, such as inducing the regeneration and maturation of cardiomyocytes, strengthening the heartbeat, and improving the consistency of the cardiac cycle, and of recovering or improving the functions of the heart, such as improving heart ejection fraction, cardiac output, and fractional shortening rate. Therefore, the cell spheroid can be used as an ingredient of a medicine, food, feed, and the like for the prevention, amelioration or treatment of heart diseases.