461 results about "Saline solutions" patented technology

The preparation method comprises the following steps: mixing a tannic acid solution and a tetravalent cerium salt solution, adjusting the pH value to 9-11, and reacting to obtain the cerium tannate nano-enzyme, the molar ratio of the tannic acid to the tetravalent cerium salt is (1-4): 1; the hydration dynamic diameter of the cerium tannate nano-enzyme is 20 to 80 nm. The TA-Ce nano-enzyme prepared by the preparation method disclosed by the invention is smaller in particle size, can keep stable and good dispersibility in a physiological environment, and has good biocompatibility, low hemolysis rate and small systemic toxicity; meanwhile, the compound has good kidney targeting property, can be effectively enriched into the injured kidney, eliminates various ROS (reactive oxygen species) and relieves oxidative stress by utilizing unique redox cycle between Ce < 3 + > and Ce < 4 + > states, and has a good effect in treating acute kidney injury induced by rhabdomyolysis and / or cis-platinum. The research lays a foundation for the metal polyphenol nano material in the treatment of acute kidney injury.

The invention discloses double-layer hydrogel for wound repair and infection monitoring as well as a preparation method and application of the double-layer hydrogel, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: (1) firstly, preparing an aldehyde dextran-mulberry extract solution; (2) preparing a chitosan quaternary ammonium salt-mulberry extract solution; (3) mixing and dissolving sodium alginate, aldehyde dextran and mulberry extract in a PBS (Phosphate Buffer Solution), so as to obtain an upper-layer hydrogel pre-polymerization solution; (4) mixing the aldehyde dextran-mulberry extract solution with the chitosan quaternary ammonium salt-mulberry extract solution, so as to prepare a lower layer hydrogel; and (5) adding the upper-layer hydrogel prepolymerization liquid above the lower-layer hydrogel, and spraying a metal cation salt solution to enable the upper-layer hydrogel to be fully crosslinked, thereby obtaining the crosslinked hydrogel with a double-layer structure. The double-layer hydrogel for wound repair and infection monitoring, prepared by the invention, has good adhesion, tensile property, antibacterial property and hemostatic property.

The present invention relates to a kind of silk fibroin hydrogel and preparation method thereof, silkworm raw silk is degummed, sol, dialyzed, filtered, freeze-dried to obtain silk fibroin freeze-dried powder, then redissolved into high concentration silk fibroin solution, filtered and spray-dried into silk fibroin microspheres; silk fibroin microspheres are slowly added to a phosphate buffered saline solution containing γ-polyglutamic acid and glutaraldehyde, stirred and ultrasonically carried out the first cross-linking, then a cross-linking agent solution is added, stirred evenly and ultrasonically, and the second cross-linking is carried out, and the silk fibroin hydrogel is obtained after being rinsed with pure water after being placed for a period of time. In the preparation method of the present invention, a phosphate buffered saline solution containing γ-polyglutamic acid and glutaraldehyde is used as a cross-linking agent and secondary cross-linking is carried out, and the prepared silk fibroin hydrogel silk fibroin has a long retention time, good stability and mechanical strength, and the cross-linking method is simple, and it is suitable for large-scale industrial production.

The invention discloses a preparation method of an ulinastatin crude product, which comprises the following steps: a, adsorbing urine of healthy adults by using macroporous adsorption resin, and then desorbing by using a salt solution to obtain an eluent; b, carrying out ultrafiltration concentration on the obtained eluent to obtain a first concentrated solution; c, purifying and eluting the concentrated solution obtained in the step b by using a lectin affinity chromatography column, and collecting a liquid phase; d, performing ultrafiltration concentration on the obtained liquid phase to obtain a second concentrated solution; and e, salting out the second concentrated solution, and filtering to obtain the ulinastatin crude product. The ulinastatin prepared by the preparation method disclosed by the invention is high in specific activity and long in shelf life.

The invention relates to the technical field of biological products, in particular to a collagen-hyaluronic acid or hyaluronate composite solution. By controlling the concentration of the collagen concentrated solution, the concentration of the hyaluronic acid / hyaluronate solution and the mass ratio of the collagen to the hyaluronic acid / hyaluronate in the composite solution, the composite solution has good storage stability and whiteness and is easy to push. The composite solution is safe to use, simple in preparation method and easy to industrialize, can be used in the field of injection medical treatment or injection filling, and has a wide application prospect.

The invention provides a preparation method of a two-dimensional high-strength coating material, which comprises the following steps: under the protection of inert gas, dissolving melamine and trimesoyl chloride as reaction monomers in a solution A, adding triethylamine as an acid-binding agent, and promoting amidation reaction through magnetic stirring; after the reaction is finished, washing with saturated saline solution and NaHCO3 to remove impurities, and then obtaining high-purity two-dimensional polymer powder through the steps of solution mixing, ultrasonic treatment, centrifugal separation and the like. And finally, dissolving polymer powder in the solution F to prepare two-dimensional polymer solutions with different concentrations, and coating the two-dimensional polymer solutions on the surface of a substrate pretreated by acetone and isopropanol to obtain a flat and compact coating film. The triethylamine is adopted as the acid binding agent, so that the purity and the reaction efficiency of the polymer are improved, the preparation controllability and the structural uniformity of the coating material are remarkably improved, and the high-performance coating requirements in the fields of machinery, chemical protection and the like are met.

The invention belongs to the technical field of biomedical materials, and particularly relates to a multi-layer multifunctional hydrogel microsphere for diabetic wounds as well as a preparation method and application of the multi-layer multifunctional hydrogel microsphere. The preparation method comprises the following steps: firstly, synthesizing a chitosan derivative with proper amino and aldehyde group contents, oxidized macromolecules and modified chitin; then preparing photocuring hydrogel microspheres by utilizing a microfluidic technology, and sequentially immersing the photocuring hydrogel microspheres into an oxidized polymer solution, a modified chitin solution, a tannic acid solution and a metal salt solution, so as to construct the hydrogel microspheres with a multifunctional layer structure. The invention further provides specific application intervals of parameters such as solvents used by various solutions, concentration ranges and soaking time. The preparation method provided by the invention has expansibility and universality, various types of microspheres can be constructed for sequential release of bioactive substances, and the requirements of tissue repair are met.

Transcatheter devices and delivery systems with various shape-memory improvements for facilitating procedures, including advancement within the body. The devices may include metallic stent features that are trained to assume certain shapes upon direct heating or cooling. Device can be trained with multiple shape memory configurations. For some devices, anchor arms extend from the device and are curled or curved at body temperature but can be straightened out when cooled. Similarly, a support structure of the devices can be trained to radially self-crimp when subjected to a reduced temperature. Various convertible elements within a delivery system can also be trained so as to enable selective disengagement. Cooling may be accomplished through the instruction of a cold saline solution, or through the use of miniature Peltier coolers mounted on the convertible elements themselves, or other means.

The invention discloses sprayable hydrogel for healing a bacterial infected wound and a preparation method of the sprayable hydrogel. The preparation method comprises the following steps: preparing a g-C3N4 nanosheet by taking melamine as a precursor, and then preparing AuNPs-C3N4 nano-enzyme on the g-C3N4 nanosheet through in-situ reduction of HAuCl4. 3H2O; preparing oxidized hyaluronic acid through a sodium periodate oxidation method; the preparation method comprises the following steps: incubating an AuNPs-C3N4 nano-enzyme solution and a glucose solution, adding a Mn < 2 + >-containing manganese salt solution and a bicarbonate solution, then mixing with an oxidized hyaluronic acid solution to obtain a dispersion liquid, spraying the dispersion liquid and a carboxymethyl chitosan solution in a cross-phase manner, and carrying out a Schiff base reaction to prepare the AuNPs-C3N4 / Glu / Mn < 2 + >-carboxymethyl chitosan-OHA hydrogel. The method is simple in preparation process, and the prepared hydrogel can have excellent in-vitro antibacterial efficiency, good biocompatibility and bacterial adsorbability, and can effectively remove bacteria at wound infection parts and promote wound healing.

The invention discloses a treatment method for fermenting smelly mandarin fish by coupling gradient salt control and directional inoculation, which comprises the following steps of: pretreating the smelly mandarin fish, putting the smelly mandarin fish into ozone-containing water for bacteria reduction treatment, then putting the smelly mandarin fish into a salt solution for pickling, finally inoculating bacteria liquid into the pickled smelly mandarin fish for fermentation treatment, cleaning, draining, packaging and quickly freezing after fermentation is finished, and thus obtaining the smelly mandarin fish. According to the method, the fermentation production process of the smelly mandarin fish is adjusted and standardized, the microorganism content of the slaughtered smelly mandarin fish is reduced through pretreatment, then the bacteria-reduced smelly mandarin fish is pickled with a low-concentration sodium chloride aqueous solution, meanwhile, the screened strains (psychrobacter halophilus and lactobacillus plantarum) are inoculated, and compared with traditional fermentation, the method is easy to operate, low in cost and high in yield. The product quality is stable, the defective rate is low, the labor cost is saved, the speed is high, the volatile basic nitrogen of the obtained smelly mandarin fish is less than or equal to 30mg / 100g, and the peroxide value (in terms of fat) is less than or equal to 2.5 g / 100g.

The invention discloses a preparation method of non-denatured II-type collagen for promoting bone and cartilage growth, and belongs to the technical field of II-type collagen extraction.The preparation method comprises the following steps that 1, pretreatment is conducted; (2) soaking in a salt solution: adding the salt solution into the cartilage particles for soaking treatment to obtain a precipitate; (3) soaking in an organic solvent; and (4) drying and crushing the solid matter to obtain the traditional Chinese medicine composition. The salt solution is prepared from the following components in percentage by mass: 1 to 5 percent of sodium chloride, 0.2 to 0.8 percent of lecithin, 0.3 to 1 percent of plant extract and the balance of water; the plant extract is a water extract of rhizoma kaempferiae, chicory and houttuynia cordata; the organic solvent is an ethanol water solution and pullulan polysaccharide. According to the method disclosed by the invention, the saline solution is improved, so that the structural stability of the collagen is improved while the dissolution of non-collagen components is promoted, the denaturation of the type II collagen is avoided, and the extraction efficiency of the non-denatured type II collagen is improved.

A drug delivery system includes a packaging housing a first component including at least one of a drug product, a diluent, a saline solution, or an IV stabilizing solution (“IVSS”) and a second component comprising at least one of the drug product, the diluent, the saline solution, and the IVSS, the first component being different than the second component. The first component is disposed in a first container in a storage state and the first container is positioned in a first compartment of the packaging housing. The second component is disposed in a second container in a storage state and the second container is positioned in a second compartment of the packaging housing. At least one of the first compartment and the second compartment may include an individual seal and wherein each of the individual seals and the first and second compartments are sterilized.

The invention relates to a composite bone repair material, a preparation method and application, the preparation method comprises the following steps: immersing silkworm cocoons in a soap salt solution for degumming, drying to prepare degummed silk, dissolving the degummed silk in a lithium bromide solution, dialyzing for desalting, and concentrating to obtain a regenerated silk protein solution; mixing the regenerated silk fibroin solution with a gelatin solution to obtain a gel solution; mechanically shaking the gel solution, so that the gel solution is uniformly mixed, uniformly distributed bubbles are formed in the gel solution, and a silk protein / gelatin gel block is obtained; soaking and cleaning the silk protein / gelatin gel block in an ammonium sulfate solution to obtain silk protein / gelatin cross-linked gel; and freeze-drying the fibroin / gelatin cross-linked gel to obtain the fibroin / gelatin composite material. The composite bone repair material has the advantages that the composite bone repair material has a bionic porous structure, has excellent mechanical properties and also has good biocompatibility and osteogenic activity. The material can be applied to filling and regeneration repair of skull defects of the orthopedics department, the oral cavity, the plastic surgery (maxillofacial) and the neurosurgery department, and has high industrial production and clinical application prospects.

The invention discloses a synthesis method of a felinone intermediate, and relates to the technical field of medicine synthesis. The synthesis method comprises the following steps: firstly, taking a 500ml four-neck flask, adding 200ml of dichloromethane, adding 40g of 3-hydroxypropionitrile, finally adding 5g of a DMAP solid material, and stirring for 1 hour; continuously dropwise adding 50 g of ketene dimer, and after temperature-controlled dropwise adding is completed, carrying out heat preservation reaction for 2 hours to obtain a reaction solution; and taking the reaction liquid, washing with 200ml of saturated saline solution, preserving heat, taking the lower-layer material, washing with 200ml of purified water, preserving heat, taking the lower-layer material, finally washing with 200ml of saturated saline solution, taking the lower-layer material, distilling, and desolventizing to obtain the target product. The preparation method comprises the following steps: putting 40g of a target product and 200ml of DMF (Dimethyl Formamide) into a 500ml four-mouth flask, stirring, then adding 50g of 4-cyano-2-methoxybenzaldehyde into a constant-pressure dropping funnel and the like; the synthesis method is stable in reaction, low in raw material price, reasonable in synthesis route, basically free of by-products in the synthesis process, and high in target product purity.

The invention discloses a system for extracting lithium from salt lake brine through capillary crystallization, and relates to the technical field of brine resource development and utilization, the system comprises multiple stages of brine pools, each stage of brine pool comprises a brine reaction pool, each stage of brine reaction pool is located in a set of heat preservation chambers, and a lithium extraction device and a control system are installed in each heat preservation chamber; the lithium extraction device comprises a plurality of groups of woven steel core ropes, the bottom ends of the woven steel core ropes are inserted below the brine liquid level of the brine reaction tank, and the woven steel core ropes comprise a plurality of groups of porous fiber bundles which have capillary action on a saline solution. Different salts are separated and extracted according to different capillary salt absorption effects of the hydrophilic porous fibers on different salts, and the technical problem that high-magnesium-lithium-ratio separation is difficult in brine separation is solved.

Methods and systems for generating electricity or hydrogen from thermal energy are disclosed. The method includes separating a first saline solution from a second saline solution by a selective permeable membrane (104), receiving thermal energy from a heat source by the first saline solution and / or the second saline solution, and mixing the first saline solution and the second saline solution in a controlled manner, the first saline solution being separated from the second saline solution as a salinity difference between the first saline solution and the second saline solution decreases. At least some salinity gradient energy is captured as electrical power. The method further includes transferring thermal energy from the first saline solution to the second saline solution by a heat pump (320), causing an increase in salinity difference between the first saline solution and the second saline solution. The methods and systems may include regeneration processes such as membrane distillation, forward osmosis, electrodialysis, salt evaporation, and / or salt decomposition for further energy efficiency and power generation.

The utility model provides multi-angle rotary experimental equipment for erosion corrosion of a high-temperature saline solution. The device is made of customized acrylic materials, a JJ-1B type motor is selected as a rotating motor, the diameter of a rotating disc is 100 mm, and three kinds of rotating discs with different impact angles are manufactured in total. The centers of the samples are fixed on a rotary erosion corrosion device through bolts, three parallel samples are arranged in each group, the experiment temperature is 80 + / -5 DEG C, and the experiment time is 120 hours. The experimental medium is deionized water and a 3.5% NaCl solution. The erosion corrosion resistance of the material can be further analyzed by recording weight change results and weightlessness experiment results of different samples.

The invention disclosed in this document presents a novel direct in-scope suction system designed for the retrieval of calculus fragments within the body. This system comprises two key components: a calculus fragments retrieval device and a pump unit. The calculus fragments retrieval device features a body with a single working channel that includes both an irrigation port and a suction port, which are connected to respective irrigation and suction pumps via elastomer-based rubber tubes. This setup allows for the controlled infusion of saline solution into the body lumens during lithotripsy procedures, ensuring clear visibility and fragment clearance. The retrieval device includes a trigger lever connected to a pincher tab. When the operator presses the trigger lever, the suction port is opened by releasing the pinched suction tube, increasing pressure inside the body.

The invention belongs to the technical field of analysis and detection of medicine related components, and particularly relates to a method for determining related substances of a methotrexate oral solution, the related substances comprise methotrexate impurity B, impurity C, impurity E, impurity D, impurity H and impurity I. The determination method adopts a high performance liquid chromatography method. A mobile phase of the high performance liquid chromatography comprises a mobile phase A and a mobile phase B, the mobile phase A is a buffer salt solution, the mobile phase B is acetonitrile, and gradient elution is adopted. According to the method, a plurality of known impurities in the methotrexate oral solution can be measured at the same time by utilizing the high performance liquid chromatography, interference generated by a blank solvent and an auxiliary material solution is eliminated, and the method can be used for accurately and quantitatively detecting related substances in the preparation process and the storage process of the methotrexate oral solution and serves as an important component for medicine quality control. The clinical use risk is reduced. The method is good in specificity, good in separation degree, good in accuracy and high in practicability in actual quality control work.

A body implantable penile prosthetic assembly includes a reservoir, a penile implant, and a pump. The reservoir is for containing a saline solution. The penile implant is penile implant operable to shift between a flaccid state in which the penile implant is at least partially depleted of the saline solution and an erect state in which the penile implant receives the saline solution from the one or more reservoirs. The pump is configured to generate pressure that causes the saline solution to flow from the reservoir to the penile implant to cause the penile implant to form the erect state. The penile implant includes a cylinder for receiving the saline solution. The cylinder is formed from a multilayered material having an inner layer comprising polyester and an outer layer comprising silicone.

The present invention relates to a process for separating rubidium ions from saline solutions rich in other monovalent ions, particularly sodium and potassium. The process relies on rubidium ions adsorption via ion exchange performed by metal-hexacy anoferrate particles. The process of the present invention provides pure rubidium salt with estimated production costs that do not exceed 20% of the current price.

The invention discloses a core-shell nano-enzyme composite spray gel dressing and a preparation method and application thereof.The dressing comprises a component A prepared from sodium alginate, N-isopropylacrylamide PNIPAM, core-shell nano-enzyme and curcumin and a component B of a divalent metal salt solution, and the component A and the component B are sprayed at the same time to form the core-shell nano-enzyme composite spray gel dressing. The preparation method of the core-shell nano enzyme comprises the following steps: mixing potassium ferrocyanide, ferric trichloride and polyvinylpyrrolidone to obtain a Prussian blue nano particle precursor solution; carrying out ultrasonic emulsification treatment and replacement on the curcumin core solution and the Prussian blue nanoparticle precursor solution; and freeze-drying to obtain the core-shell nano-enzyme. Through rapid ionic crosslinking of sodium alginate and divalent metal ions and the temperature-sensitive phase change characteristic of the temperature-sensitive polymer poly (N-isopropylacrylamide), the gel dressing is rapidly formed, the damaged skin is effectively covered and protected, the excellent antioxidant, anti-inflammatory and antibacterial capabilities are achieved, and the healing cycle of the radiodermatitis wound can be remarkably shortened.

The invention belongs to the field of medical isotope separation and preparation, and particularly relates to a method for separating and purifying < 212 > Pb from a thorium solution, which comprises the following steps: 1) leacheate is introduced into a Pb selective adsorption column to pretreat the Pb selective adsorption column, and then < 232 > Th salt solution and leacheate are introduced in sequence; 2) continuously introducing a desorption solution into the Pb selective adsorption column, enabling the desorption solution passing through the Pb selective adsorption column to flow into the Th selective adsorption column, and collecting the outflowing desorption solution; a desorption solution only containing 212Pb is obtained; according to the method, the 212Pb in the high-concentration thorium solution can be separated and purified at the same time. While < 232 > Th impurity entrainment and pollution in a < 212 > Pb product are remarkably reduced, compared with a single-column process, the separation time is basically not increased. The separated 212Pb product has high radionuclide purity and chemical purity at the same time, and can meet related pharmaceutical requirements.

The invention discloses an experimental method and system for evaluating the sealing capability of a microcrack of wellbore annulus cement stone. The method comprises the following steps: step 1, preparing cement paste; 2, curing the cement paste to obtain a set cement sample; 3, a saline solution is prepared according to the formation water mineralization degree; 4, placing the saline solution and CO2 in a piston type intermediate container; 5, the set cement sample is saturated with saline water; step 6, pressurizing the cement stone sample saturated with the saline water to form a crack, so as to obtain the initial permeability of the cement stone sample; step 7, putting the cement stone sample subjected to fracture forming into a core holder, and monitoring the pressure of the inlet end of the core holder; when the pressure change of the inlet end of the core holder reaches an expected rising and falling trend, collecting data of the pressure of the inlet end to obtain an end point permeability; 8, if the terminal permeability is lower than the initial permeability, it shows that the set cement sample has the micro-crack self-sealing capacity. The experimental method and system simulate and measure the change of the sealing performance in the shaft direction.

An acoustic technique designed to increase the gas-dissolution rate of a bubble in a liquid media is proposed. Increased gas-dissolution rate is achieved by increasing the bubble's surface-to-volume ratio via bubble fragmentation. This is achieved by attaching an electroacoustic transducer to the system or load in which bubbles travel and exciting the transducer at the frequency of resonance. The electric resonance of the transducer attached to the system corresponds in frequency to the mechanical resonance of the system or load which allows for achieving such state without the use of an internally placed hydrophone to certify the resonance state. The acoustic bubble fragmentation technique increased the dissolution rate 4 to 5 times of bubbles with initial diameters between 150 and 550 μm in distilled water and in medical grade saline solution.

Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of the user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The saline solution source bottle is disposed relative to the device to provide gravitational inducement of saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and the relative vacuum from an effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of a user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils.

A nasal irrigation monitoring and congestion mapping system is disclosed herein. The system comprises an electrical nasal irrigation device and a mobile application. In an embodiment, the electrical nasal irrigation device includes an electronic pump circuit having a microcontroller unit (MCU) configured to control the operation of the pump and pressure modes and a pressure detection sensor to measure the flow rate of saline solution to identify pressure fluctuation data in the nasal passages during saline delivery, and provide real-time data on nasal congestion levels. A mobile application is communicatively connected to the nasal irrigation device to receive and interpret the pressure fluctuation data using congestion mapping algorithm to assess a degree of nasal congestion, and map the congestion severity as nasal congestion data based on the degree of nasal congestion.

The invention discloses a preparation method of an oral bone repair hydrogel periosteum material, which comprises the following steps: reacting a natural polysaccharide solution with a metal salt to obtain a gelatinous substance, then drying to obtain a membranous substance, and mineralizing and drying the membranous substance in a metal salt solution to obtain the oral bone repair hydrogel periosteum material. The periosteum material with one hydrophilic side and the other hydrophobic side is obtained through metal ion mineralization and drying reforming. The obtained periosteum material is high in tensile strength and plastic in shape, the requirement for high mechanical performance needed in oral bone repair is met, the periosteum can be well attached to the periphery of bone defect tissue, and the degradation period is matched with the treatment period of oral bone repair. The preparation method is simple, low in cost and suitable for being used as a periosteum material for oral bone repair.

The invention discloses lactobacillus gallinarum, a micro-ecological additive and application of the lactobacillus gallinarum and the micro-ecological additive, the lactobacillus gallinarum is named as lactobacillus gallinarum CD-13 and is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC M 20241172, and the nucleotide sequence of 16SrDNA of the lactobacillus gallinarum is SEQ ID NO.1. The lactobacillus gallinarum is named as lactobacillus gallinarum CD-13 and is preserved in the China Center for Type Culture Collection. The lactobacillus gallus CD-13 provided by the invention is good in stress resistance and can tolerate a strong acid environment, the survival rate of the lactobacillus gallus CD-13 in a solution with the pH value of 2.5 is 107.62%, and the lactobacillus gallus CD-13 has very strong tolerance to acidity. And the survival rate in a 0.3% cholate solution is 12.97%. In a high bile salt environment, the resistance is relatively poor, but a small amount of the strain still can survive, the stress resistance is relatively good, and the strain can adapt to a gastrointestinal tract environment. When the lactobacillus gallus CD-13 provided by the invention is added into drinking water as a micro-ecological additive, the lactobacillus gallus CD-13 has an obvious growth promoting effect on broiler chickens.

The invention provides an oral thylakoid product for resisting organ failure and aging, which is prepared by the following steps: extracting thylakoid from plants including spinach, arabidopsis thaliana, lettuce, cabbage, green algae or wheat seedlings, redissolving the thylakoid into a buffer salt solution A, and carrying out ultrasonic treatment for 10-20 minutes under the ultrasonic power of 200-500W to prepare a suspension; adjusting the concentration of the suspension to 0.5-2 mg / ml, and obtaining a nano capsule-like body with the particle size of 200-500 nm by using a microfluidic technology; the buffer salt solution A is prepared from 10 to 100 mmol / L of 4-hydroxyethyl piperazine ethanesulfonic acid (HEPES), 1 to 2 mmol / L of ethylenediamine tetraacetic acid (EDTA) disodium, 0.5 to 4 mmol / L of magnesium chloride (MgCl2), 1 to 10 mmol / L of ascorbic acid and 100 to 500 mmol / L of sapoeda sodium (SNAC), and the pH value of the buffer salt solution A is adjusted to 7.5 to 8.0; and the concentration of the capsule in the buffer salt solution A is 100-400 mg / mL. According to the product, self QPRT enzyme of the thylakoid is used for efficiently catalyzing de novo synthesis of NAD + of whole body tissues and organs, so that multiple physiological processes such as energy synthesis enhancement, oxidative stress reduction and inflammatory reaction relief are finally realized, organ failure is efficiently reversed, and organ aging is relieved.