359 results about "Saline solutions" patented technology

The invention relates to the technical field of biological products, in particular to a collagen-hyaluronic acid or hyaluronate composite solution. By controlling the concentration of the collagen concentrated solution, the concentration of the hyaluronic acid / hyaluronate solution and the mass ratio of the collagen to the hyaluronic acid / hyaluronate in the composite solution, the composite solution has good storage stability and whiteness and is easy to push. The composite solution is safe to use, simple in preparation method and easy to industrialize, can be used in the field of injection medical treatment or injection filling, and has a wide application prospect.

The invention provides a preparation method of a two-dimensional high-strength coating material, which comprises the following steps: under the protection of inert gas, dissolving melamine and trimesoyl chloride as reaction monomers in a solution A, adding triethylamine as an acid-binding agent, and promoting amidation reaction through magnetic stirring; after the reaction is finished, washing with saturated saline solution and NaHCO3 to remove impurities, and then obtaining high-purity two-dimensional polymer powder through the steps of solution mixing, ultrasonic treatment, centrifugal separation and the like. And finally, dissolving polymer powder in the solution F to prepare two-dimensional polymer solutions with different concentrations, and coating the two-dimensional polymer solutions on the surface of a substrate pretreated by acetone and isopropanol to obtain a flat and compact coating film. The triethylamine is adopted as the acid binding agent, so that the purity and the reaction efficiency of the polymer are improved, the preparation controllability and the structural uniformity of the coating material are remarkably improved, and the high-performance coating requirements in the fields of machinery, chemical protection and the like are met.

The invention belongs to the technical field of biomedical materials, and particularly relates to a multi-layer multifunctional hydrogel microsphere for diabetic wounds as well as a preparation method and application of the multi-layer multifunctional hydrogel microsphere. The preparation method comprises the following steps: firstly, synthesizing a chitosan derivative with proper amino and aldehyde group contents, oxidized macromolecules and modified chitin; then preparing photocuring hydrogel microspheres by utilizing a microfluidic technology, and sequentially immersing the photocuring hydrogel microspheres into an oxidized polymer solution, a modified chitin solution, a tannic acid solution and a metal salt solution, so as to construct the hydrogel microspheres with a multifunctional layer structure. The invention further provides specific application intervals of parameters such as solvents used by various solutions, concentration ranges and soaking time. The preparation method provided by the invention has expansibility and universality, various types of microspheres can be constructed for sequential release of bioactive substances, and the requirements of tissue repair are met.

Transcatheter devices and delivery systems with various shape-memory improvements for facilitating procedures, including advancement within the body. The devices may include metallic stent features that are trained to assume certain shapes upon direct heating or cooling. Device can be trained with multiple shape memory configurations. For some devices, anchor arms extend from the device and are curled or curved at body temperature but can be straightened out when cooled. Similarly, a support structure of the devices can be trained to radially self-crimp when subjected to a reduced temperature. Various convertible elements within a delivery system can also be trained so as to enable selective disengagement. Cooling may be accomplished through the instruction of a cold saline solution, or through the use of miniature Peltier coolers mounted on the convertible elements themselves, or other means.

The invention discloses a treatment method for fermenting smelly mandarin fish by coupling gradient salt control and directional inoculation, which comprises the following steps of: pretreating the smelly mandarin fish, putting the smelly mandarin fish into ozone-containing water for bacteria reduction treatment, then putting the smelly mandarin fish into a salt solution for pickling, finally inoculating bacteria liquid into the pickled smelly mandarin fish for fermentation treatment, cleaning, draining, packaging and quickly freezing after fermentation is finished, and thus obtaining the smelly mandarin fish. According to the method, the fermentation production process of the smelly mandarin fish is adjusted and standardized, the microorganism content of the slaughtered smelly mandarin fish is reduced through pretreatment, then the bacteria-reduced smelly mandarin fish is pickled with a low-concentration sodium chloride aqueous solution, meanwhile, the screened strains (psychrobacter halophilus and lactobacillus plantarum) are inoculated, and compared with traditional fermentation, the method is easy to operate, low in cost and high in yield. The product quality is stable, the defective rate is low, the labor cost is saved, the speed is high, the volatile basic nitrogen of the obtained smelly mandarin fish is less than or equal to 30mg / 100g, and the peroxide value (in terms of fat) is less than or equal to 2.5 g / 100g.

The invention discloses a preparation method of non-denatured II-type collagen for promoting bone and cartilage growth, and belongs to the technical field of II-type collagen extraction.The preparation method comprises the following steps that 1, pretreatment is conducted; (2) soaking in a salt solution: adding the salt solution into the cartilage particles for soaking treatment to obtain a precipitate; (3) soaking in an organic solvent; and (4) drying and crushing the solid matter to obtain the traditional Chinese medicine composition. The salt solution is prepared from the following components in percentage by mass: 1 to 5 percent of sodium chloride, 0.2 to 0.8 percent of lecithin, 0.3 to 1 percent of plant extract and the balance of water; the plant extract is a water extract of rhizoma kaempferiae, chicory and houttuynia cordata; the organic solvent is an ethanol water solution and pullulan polysaccharide. According to the method disclosed by the invention, the saline solution is improved, so that the structural stability of the collagen is improved while the dissolution of non-collagen components is promoted, the denaturation of the type II collagen is avoided, and the extraction efficiency of the non-denatured type II collagen is improved.

A drug delivery system includes a packaging housing a first component including at least one of a drug product, a diluent, a saline solution, or an IV stabilizing solution (“IVSS”) and a second component comprising at least one of the drug product, the diluent, the saline solution, and the IVSS, the first component being different than the second component. The first component is disposed in a first container in a storage state and the first container is positioned in a first compartment of the packaging housing. The second component is disposed in a second container in a storage state and the second container is positioned in a second compartment of the packaging housing. At least one of the first compartment and the second compartment may include an individual seal and wherein each of the individual seals and the first and second compartments are sterilized.

The invention relates to a composite bone repair material, a preparation method and application, the preparation method comprises the following steps: immersing silkworm cocoons in a soap salt solution for degumming, drying to prepare degummed silk, dissolving the degummed silk in a lithium bromide solution, dialyzing for desalting, and concentrating to obtain a regenerated silk protein solution; mixing the regenerated silk fibroin solution with a gelatin solution to obtain a gel solution; mechanically shaking the gel solution, so that the gel solution is uniformly mixed, uniformly distributed bubbles are formed in the gel solution, and a silk protein / gelatin gel block is obtained; soaking and cleaning the silk protein / gelatin gel block in an ammonium sulfate solution to obtain silk protein / gelatin cross-linked gel; and freeze-drying the fibroin / gelatin cross-linked gel to obtain the fibroin / gelatin composite material. The composite bone repair material has the advantages that the composite bone repair material has a bionic porous structure, has excellent mechanical properties and also has good biocompatibility and osteogenic activity. The material can be applied to filling and regeneration repair of skull defects of the orthopedics department, the oral cavity, the plastic surgery (maxillofacial) and the neurosurgery department, and has high industrial production and clinical application prospects.

The invention discloses a synthesis method of a felinone intermediate, and relates to the technical field of medicine synthesis. The synthesis method comprises the following steps: firstly, taking a 500ml four-neck flask, adding 200ml of dichloromethane, adding 40g of 3-hydroxypropionitrile, finally adding 5g of a DMAP solid material, and stirring for 1 hour; continuously dropwise adding 50 g of ketene dimer, and after temperature-controlled dropwise adding is completed, carrying out heat preservation reaction for 2 hours to obtain a reaction solution; and taking the reaction liquid, washing with 200ml of saturated saline solution, preserving heat, taking the lower-layer material, washing with 200ml of purified water, preserving heat, taking the lower-layer material, finally washing with 200ml of saturated saline solution, taking the lower-layer material, distilling, and desolventizing to obtain the target product. The preparation method comprises the following steps: putting 40g of a target product and 200ml of DMF (Dimethyl Formamide) into a 500ml four-mouth flask, stirring, then adding 50g of 4-cyano-2-methoxybenzaldehyde into a constant-pressure dropping funnel and the like; the synthesis method is stable in reaction, low in raw material price, reasonable in synthesis route, basically free of by-products in the synthesis process, and high in target product purity.

The invention disclosed in this document presents a novel direct in-scope suction system designed for the retrieval of calculus fragments within the body. This system comprises two key components: a calculus fragments retrieval device and a pump unit. The calculus fragments retrieval device features a body with a single working channel that includes both an irrigation port and a suction port, which are connected to respective irrigation and suction pumps via elastomer-based rubber tubes. This setup allows for the controlled infusion of saline solution into the body lumens during lithotripsy procedures, ensuring clear visibility and fragment clearance. The retrieval device includes a trigger lever connected to a pincher tab. When the operator presses the trigger lever, the suction port is opened by releasing the pinched suction tube, increasing pressure inside the body.

The invention belongs to the technical field of analysis and detection of medicine related components, and particularly relates to a method for determining related substances of a methotrexate oral solution, the related substances comprise methotrexate impurity B, impurity C, impurity E, impurity D, impurity H and impurity I. The determination method adopts a high performance liquid chromatography method. A mobile phase of the high performance liquid chromatography comprises a mobile phase A and a mobile phase B, the mobile phase A is a buffer salt solution, the mobile phase B is acetonitrile, and gradient elution is adopted. According to the method, a plurality of known impurities in the methotrexate oral solution can be measured at the same time by utilizing the high performance liquid chromatography, interference generated by a blank solvent and an auxiliary material solution is eliminated, and the method can be used for accurately and quantitatively detecting related substances in the preparation process and the storage process of the methotrexate oral solution and serves as an important component for medicine quality control. The clinical use risk is reduced. The method is good in specificity, good in separation degree, good in accuracy and high in practicability in actual quality control work.

A body implantable penile prosthetic assembly includes a reservoir, a penile implant, and a pump. The reservoir is for containing a saline solution. The penile implant is penile implant operable to shift between a flaccid state in which the penile implant is at least partially depleted of the saline solution and an erect state in which the penile implant receives the saline solution from the one or more reservoirs. The pump is configured to generate pressure that causes the saline solution to flow from the reservoir to the penile implant to cause the penile implant to form the erect state. The penile implant includes a cylinder for receiving the saline solution. The cylinder is formed from a multilayered material having an inner layer comprising polyester and an outer layer comprising silicone.

The invention discloses a core-shell nano-enzyme composite spray gel dressing and a preparation method and application thereof.The dressing comprises a component A prepared from sodium alginate, N-isopropylacrylamide PNIPAM, core-shell nano-enzyme and curcumin and a component B of a divalent metal salt solution, and the component A and the component B are sprayed at the same time to form the core-shell nano-enzyme composite spray gel dressing. The preparation method of the core-shell nano enzyme comprises the following steps: mixing potassium ferrocyanide, ferric trichloride and polyvinylpyrrolidone to obtain a Prussian blue nano particle precursor solution; carrying out ultrasonic emulsification treatment and replacement on the curcumin core solution and the Prussian blue nanoparticle precursor solution; and freeze-drying to obtain the core-shell nano-enzyme. Through rapid ionic crosslinking of sodium alginate and divalent metal ions and the temperature-sensitive phase change characteristic of the temperature-sensitive polymer poly (N-isopropylacrylamide), the gel dressing is rapidly formed, the damaged skin is effectively covered and protected, the excellent antioxidant, anti-inflammatory and antibacterial capabilities are achieved, and the healing cycle of the radiodermatitis wound can be remarkably shortened.

The invention belongs to the field of medical isotope separation and preparation, and particularly relates to a method for separating and purifying < 212 > Pb from a thorium solution, which comprises the following steps: 1) leacheate is introduced into a Pb selective adsorption column to pretreat the Pb selective adsorption column, and then < 232 > Th salt solution and leacheate are introduced in sequence; 2) continuously introducing a desorption solution into the Pb selective adsorption column, enabling the desorption solution passing through the Pb selective adsorption column to flow into the Th selective adsorption column, and collecting the outflowing desorption solution; a desorption solution only containing 212Pb is obtained; according to the method, the 212Pb in the high-concentration thorium solution can be separated and purified at the same time. While < 232 > Th impurity entrainment and pollution in a < 212 > Pb product are remarkably reduced, compared with a single-column process, the separation time is basically not increased. The separated 212Pb product has high radionuclide purity and chemical purity at the same time, and can meet related pharmaceutical requirements.

The invention discloses an experimental method and system for evaluating the sealing capability of a microcrack of wellbore annulus cement stone. The method comprises the following steps: step 1, preparing cement paste; 2, curing the cement paste to obtain a set cement sample; 3, a saline solution is prepared according to the formation water mineralization degree; 4, placing the saline solution and CO2 in a piston type intermediate container; 5, the set cement sample is saturated with saline water; step 6, pressurizing the cement stone sample saturated with the saline water to form a crack, so as to obtain the initial permeability of the cement stone sample; step 7, putting the cement stone sample subjected to fracture forming into a core holder, and monitoring the pressure of the inlet end of the core holder; when the pressure change of the inlet end of the core holder reaches an expected rising and falling trend, collecting data of the pressure of the inlet end to obtain an end point permeability; 8, if the terminal permeability is lower than the initial permeability, it shows that the set cement sample has the micro-crack self-sealing capacity. The experimental method and system simulate and measure the change of the sealing performance in the shaft direction.

An acoustic technique designed to increase the gas-dissolution rate of a bubble in a liquid media is proposed. Increased gas-dissolution rate is achieved by increasing the bubble's surface-to-volume ratio via bubble fragmentation. This is achieved by attaching an electroacoustic transducer to the system or load in which bubbles travel and exciting the transducer at the frequency of resonance. The electric resonance of the transducer attached to the system corresponds in frequency to the mechanical resonance of the system or load which allows for achieving such state without the use of an internally placed hydrophone to certify the resonance state. The acoustic bubble fragmentation technique increased the dissolution rate 4 to 5 times of bubbles with initial diameters between 150 and 550 μm in distilled water and in medical grade saline solution.

Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of the user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The saline solution source bottle is disposed relative to the device to provide gravitational inducement of saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and the relative vacuum from an effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of a user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils.

A nasal irrigation monitoring and congestion mapping system is disclosed herein. The system comprises an electrical nasal irrigation device and a mobile application. In an embodiment, the electrical nasal irrigation device includes an electronic pump circuit having a microcontroller unit (MCU) configured to control the operation of the pump and pressure modes and a pressure detection sensor to measure the flow rate of saline solution to identify pressure fluctuation data in the nasal passages during saline delivery, and provide real-time data on nasal congestion levels. A mobile application is communicatively connected to the nasal irrigation device to receive and interpret the pressure fluctuation data using congestion mapping algorithm to assess a degree of nasal congestion, and map the congestion severity as nasal congestion data based on the degree of nasal congestion.

The invention discloses a preparation method of an oral bone repair hydrogel periosteum material, which comprises the following steps: reacting a natural polysaccharide solution with a metal salt to obtain a gelatinous substance, then drying to obtain a membranous substance, and mineralizing and drying the membranous substance in a metal salt solution to obtain the oral bone repair hydrogel periosteum material. The periosteum material with one hydrophilic side and the other hydrophobic side is obtained through metal ion mineralization and drying reforming. The obtained periosteum material is high in tensile strength and plastic in shape, the requirement for high mechanical performance needed in oral bone repair is met, the periosteum can be well attached to the periphery of bone defect tissue, and the degradation period is matched with the treatment period of oral bone repair. The preparation method is simple, low in cost and suitable for being used as a periosteum material for oral bone repair.

The invention provides an oral thylakoid product for resisting organ failure and aging, which is prepared by the following steps: extracting thylakoid from plants including spinach, arabidopsis thaliana, lettuce, cabbage, green algae or wheat seedlings, redissolving the thylakoid into a buffer salt solution A, and carrying out ultrasonic treatment for 10-20 minutes under the ultrasonic power of 200-500W to prepare a suspension; adjusting the concentration of the suspension to 0.5-2 mg / ml, and obtaining a nano capsule-like body with the particle size of 200-500 nm by using a microfluidic technology; the buffer salt solution A is prepared from 10 to 100 mmol / L of 4-hydroxyethyl piperazine ethanesulfonic acid (HEPES), 1 to 2 mmol / L of ethylenediamine tetraacetic acid (EDTA) disodium, 0.5 to 4 mmol / L of magnesium chloride (MgCl2), 1 to 10 mmol / L of ascorbic acid and 100 to 500 mmol / L of sapoeda sodium (SNAC), and the pH value of the buffer salt solution A is adjusted to 7.5 to 8.0; and the concentration of the capsule in the buffer salt solution A is 100-400 mg / mL. According to the product, self QPRT enzyme of the thylakoid is used for efficiently catalyzing de novo synthesis of NAD + of whole body tissues and organs, so that multiple physiological processes such as energy synthesis enhancement, oxidative stress reduction and inflammatory reaction relief are finally realized, organ failure is efficiently reversed, and organ aging is relieved.

A method and system of generating electrical power or hydrogen from thermal energy is disclosed. The method includes adding heat to (or removing heat from) a salinity gradient generator configured to generate a more concentrated and a less concentrated saline solution. The method further includes drawing the more concentrated saline solution and the less concentrated saline solution from the salinity gradient generator and feeding the more concentrated saline solution and the less concentrated saline solution into a power generator. Feeding the saline solutions into the power generator causes the power generator to receive the saline solutions and generate power by performing a controlled mixing of the more concentrated saline solution and the less concentrated saline solution. The method further includes drawing, from the power generator, a combined saline solution comprising the mixed saline solutions and feeding the combined saline solution to the salinity gradient generator.

The invention relates to the technical field of pharmaceutical analysis, in particular to a detection method of a compound sodium picosulfate oral solution, which is used for detecting sodium picosulfate and related substances. The detection method comprises the following steps: carrying out liquid chromatography detection on the compound sodium picosulfate oral solution; the conditions of the liquid chromatography detection are as follows: (1) a chromatographic column is a reverse C18 chromatographic column or an efficiency equivalent column thereof; (2) taking a mixed solution of an ammonium acetate buffer salt solution and methanol as a mobile phase A and acetonitrile as a mobile phase B; wherein the pH value of the ammonium acetate buffer salt solution is 4.9 to 5.2; and (3) gradient elution is adopted. The quality detection method disclosed by the invention can be used for the preparation process of the compound sodium picosulfate oral solution and the quality control of the final product, is good in specificity, good in separation degree, high in sensitivity and good in reproducibility, and has important significance for evaluating the advantages and disadvantages of synthesis and preparation processes, controlling the quality of the final product and detecting a stable sample.

The present invention relates to a method for synthesizing nanoparticles comprising or containing at least one zeolite nanocrystal, comprising: - preparing a first composition / solution 1 comprising an aluminum source and a source of alkali metal M, particularly Na ions; - preparing a second composition / solution 2 comprising a silicon source and a source of alkali metal M, particularly Na ions, wherein compositions / solutions 1 and 2 contain no organic structuring agents; - mixing the two compositions / solutions 1 and 2; - crystallizing the mixture; and - separating the nanoparticles thus formed. According to the present invention, both the first composition / solution 1 and the second composition / solution 2 comprise the sources and alkaline phosphate buffer (PBS). The present invention also relates to the obtained nanoparticles and compositions comprising them.

This invention belongs to the field of biochemical detection and discloses a portable hepatitis biomarker detection kit. The kit contains a hydrogel; the hydrogel is obtained by dispersing hollow manganese dioxide in water to obtain an H-MnO2 dispersion, mixing the H-MnO2 dispersion with sodium alginate solution to obtain a mixed solution, and then adding a calcium salt solution to obtain the hydrogel. The hollow manganese dioxide is obtained by etching manganese Prussian blue analog nanoparticles with sodium hydroxide. The manganese Prussian blue analog nanoparticles are prepared from potassium ferricyanide, polyvinylpyrrolidone, and manganese salts. This invention utilizes the color change of hollow manganese dioxide in relation to TMB to construct a method for detecting hepatitis biomarkers using a smartphone to capture signals. This kit reduces the detection cost of hepatitis biomarkers, does not require large instruments, and is highly portable and widely applicable, possessing great potential as a novel point-of-care testing device.

The application discloses an injectable self-healing self-assembling protamine extract hydrogel and a preparation method and application thereof, and belongs to the technical field of hydrogel materials and wound repair. The hydrogel is prepared by mixing protamine extract and a crosslinking agent solution; the crosslinking agent solution comprises a salt solution with a final concentration of 0.01-4.5 M, 0.01-0.1 M sodium citrate and 0.01-0.1 M sodium bicarbonate; the protamine extract is mixed with the crosslinking agent solution at different proportions (1%-50%, w / v%) and is stirred at 20-35 DEG C until complete gelation; and a series of hydrogels can be prepared after multiple freeze-thaw cycles. The hydrogel prepared by the application has good self-healing, injectable characteristics, blood compatibility and tissue regeneration capacity, and has a wide application prospect.

The present application relates to the technical field of pharmaceutical formulations and provides zedoary turmeric oil / oxidized regenerated cellulose embolization microspheres, a preparation method therefor, and use thereof. In the present application, with zedoary turmeric oil as a core solution, a mixed solution of oxidized regenerated cellulose, sodium alginate, and gelatin as a shell layer solution, and a divalent or trivalent metal salt solution as a receiving solution, the zedoary turmeric oil / oxidized regenerated cellulose embolization microspheres are prepared by means of a coaxial electrostatic spraying method. The zedoary turmeric oil / oxidized regenerated cellulose embolization microspheres prepared in the present application have a marked core-shell structure, are uniform in size and good in sphericity, can effectively hide the pungent smell of zedoary turmeric oil, improves the stability of zedoary turmeric oil, and enables directed embolization in tumor blood vessels, thereby reducing toxic and side effects. In addition, the embolization microspheres prepared in the present application have good mechanical properties; therefore, the microspheres can effectively resist deformation under compression and prevent fragmentation within the body, enabling firm embolization of zedoary turmeric oil at the tumor vascular site.

This invention provides a transcervical access system for moving fluids transcervically. [Solution] The transcervical access system 100 is effective in transferring a wide range of fluids into the uterine cavity, including the delivery of a hydrogel precursor, saline solution, and imaging fluid. The transcervical access system 100 is also effective in removing fluids, such as residual bodily fluids, residual fluids from procedures, or tissue from the uterine cavity. The transcervical access system 100 includes a flow limiter, such as an outflow limiter 106 and / or a cervical plug. A method of using the transcervical access system 100 involves using the transcervical access system 100 to transcervically access the uterine cavity and to install the hydrogel. The transcervical access system 100 and related methods are useful in preventing adhesions after intrauterine procedures by providing a biodegradable hydrogel within the uterine cavity, including the cervix.

The primary culture method of the porcine ovary granular cells comprises the following steps: step 1, taking a fresh porcine ovary, quickly putting the porcine ovary into a Hank's balanced salt solution preheated at 38 DEG C for transportation, repeatedly washing the ovary with the Hank's balanced salt solution to remove blood and impurities, and then extracting follicular fluid with a 5ml syringe under a sterile condition; according to the method, the granular cells can be effectively separated and cultured from the porcine ovary, and the porcine ovary granular cells with higher purity and better activity can be obtained, so that the subsequent cell biology experiment research, such as gene transfection, protein expression analysis and the like, is facilitated; a cell model is provided for researching the physiological functions (such as hormone secretion and follicle development regulation and control) of the porcine ovarian granular cells, the operation is relatively simple, the cost is relatively low, and the used reagents and instruments are common in a cell culture laboratory and are convenient to popularize and apply.

The utility model relates to the technical field of brine solution sedimentation, in particular to sedimentation equipment for solid particles in brine solution, which comprises a main box body, an overflow plate is arranged in an inner cavity of the main box body, and the inner cavity of the main box body is divided into a lower-layer sedimentation cavity and an upper-layer overflow cavity by the overflow plate; and overflow ports which are distributed at intervals are formed in the overflow plate. By designing the settling equipment for the solid particles in the saline solution, which comprises the main box body, the overflow plate, the liquid inlet pipe and the liquid discharge pipe, the effective separation of the solid particles and the saline solution is realized. Overflow ports distributed on the overflow plate at intervals allow clear saline water to enter the upper overflow cavity and be discharged through a liquid discharge pipe, and solid particles sink to the bottom under the action of gravity. An upper baffle plate and a lower baffle plate are arranged in the lower settling cavity, so that the flowing time of the saline water is prolonged, the settling efficiency of solid particles is improved, and the purity of the discharged saline water solution is ensured.

The present invention relates to aqueous saline solutions comprising dantrolene and optionally at least one additional active ingredient, such as botulinum neurotoxin, and their use for various therapeutic and / or aesthetic purposes. The solutions can be administered in any suitable manner, but have the advantage of being particularly well-suited for intramuscular injection.