640 results about "Venous blood" patented technology

The invention relates to the technical field of medical clinical auxiliary diagnosis, in particular to an orthopedic postoperative complication early detection and early warning system based on data analysis, which comprises a multi-modal sign synchronous acquisition module, a sign dynamic difference quantification module, a complication feature association module, a grading early warning decision module and a dissection calibration visualization module. Wherein the multi-modal sign synchronous acquisition module is used for acquiring postoperative data of a patient; calculating a difference quantization parameter; the complication characteristic association module is used for identifying associated risk characteristics of the osteofascia ventricular syndrome, the deep venous thrombosis and the fat embolism; and the grading early warning decision module is used for generating a three-level early warning instruction based on the associated risk characteristics. According to the system and the method, through a multi-modal sign synchronous acquisition, difference quantification and grading early warning linkage mechanism, accurate recognition, risk grade division and visual intervention guidance of postoperative complications are realized, and the continuity of postoperative monitoring and the timeliness of early warning are improved.

The invention relates to a spontaneous cerebral hemorrhage postoperative intermuscular venous thrombosis risk prediction system based on a molecular mechanism and multi-modal data and a use method thereof, image space features are extracted through a multi-modal data level CNN to be complementary with time sequence features captured and detected by Transform, and support is provided for blood coagulation-endothelium-fibrinolysis three-channel activation degree calculation; a knowledge graph alignment module of a pathology and data level maps the cross-modal features to a unified semantic space, and corrects data conflicts with pathology time sequence constraints; and channel-space-time triple attention linkage at a space-time level is carried out, and a high-risk area is accurately marked. In a path driving layer, three-path activation degrees cooperatively adjust a dynamic time window, a single-path standard-exceeding triggering monitoring interval is shortened, and a double-path standard-exceeding amplitude is multiplied; and in a closed-loop feedback layer, system parameters are updated through confidence, pathological probability and conflict signal recursion, real-time calibration of a pathological mechanism and data is realized, and thrombus risk prevention and control efficiency is comprehensively improved.

The invention discloses a venous thrombosis risk assessment method based on a large language model, and relates to the technical field of medical artificial intelligence, and the method comprises the steps: collecting thoracic surgery diagnosis and treatment data of a patient, carrying out the space-time alignment, generating a standard diagnosis and treatment data flow, and carrying out the homomorphic encryption of the standard diagnosis and treatment data flow, and forming an encrypted patient data package; inputting the encrypted patient data packet into a multi-task large language model, performing feature extraction and semantic coding by a feature coding layer, performing time sequence modeling and risk probability calculation by a risk quantification layer, and outputting a venous thromboembolism risk level of a patient; and performing feature decoupling and potential space mapping on the encrypted patient data packet to obtain thrombus semantic potential features. Through the multi-task large language model, the dual machine learning algorithm and the homomorphic encryption, the accuracy of venous thrombosis risk early warning is improved, and the safety of the risk assessment process is enhanced.

The embodiment of the invention provides a continuous blood oxygen monitoring system in extracorporeal circulation and a control method thereof. The continuous blood oxygen monitoring system comprises a vein sensor, an artery sensor, a blood flow sensor, an oxygen sensor, a carbon dioxide sensor, a controller and a display, the vein sensor monitors the vein blood oxygen saturation degree; the artery sensor monitors arterial oxygen saturation and hematocrit; the blood flow sensor monitors the blood flow of the artery pipeline; the oxygen sensor monitors the oxygen concentration of the oxygenator; the carbon dioxide sensor monitors the carbon dioxide concentration of the oxygenator; the display provides an interaction control, responds to a trigger operation acting on the interaction control, sends an interaction instruction to the controller, and updates information displayed in an interaction interface according to the control of the controller; the controller receives the interaction instruction and executes processing corresponding to the interaction instruction; the processing includes controlling display information of the display; the display information comprises information corresponding to the monitoring parameters. The scheme ensures the safety and effectiveness of the treatment process.

The invention discloses a vasculopathy risk identification system based on a machine learning model. A control host acquires a blood oxygen value, a pH value, a lactic acid value and a pressure value in blood vessel blood of an evaluator and a blood vessel inner wall structure image; the blood vessel is a vein blood vessel, analyzing the tube diameter and the thickness of the intima, the medium and the adventitia based on the structure image, inputting the blood oxygen value, the pH value, the lactic acid value, the pressure value, the tube diameter and the thickness of the intima, the medium and the adventitia of the assessor into a target vein blood vessel machine learning model, and training and outputting a vein blood vessel lesion risk identification result; the blood vessel is an artery blood vessel, and the composition and form of the artery blood vessel are identified and the stenosis degree value of the vessel diameter is calculated when the vessel diameter, the thickness of the inner, middle and outer membranes and artery plaques exist in the artery blood vessel are analyzed based on the structure image; and inputting the blood oxygen value, the pH value, the lactic acid value, the pressure value, the tube diameter, the thickness of the intima, the middle and the adventitia of the blood vessel, the composition and the form of the artery plaque and the tube diameter stenosis degree value of the assessor into a target artery blood vessel machine learning model to train and output an artery blood vessel lesion risk identification result.

The invention discloses a multifunctional safe flushing system for hemodialysis, and belongs to the technical field of blood purification. The system comprises an arterial blood extraction assembly, a venous blood transfusion assembly and a plasma purification treatment assembly, one end of the venous blood transfusion assembly is connected with one end of the arterial blood extraction assembly through a plasma separator, one end of the plasma purification treatment assembly is connected with the plasma separator, and the other end of the plasma purification treatment assembly is connected with the venous blood transfusion assembly. A multifunctional safe flushing mechanism is arranged at the position, close to the plasma separator, of the plasma purification treatment assembly. During flushing, due to the fact that the path from the multifunctional safe flushing mechanism to the adsorber in the plasma purification treatment assembly is short, the time needed for flushing is shortened, the effective treatment duration is guaranteed, the needed amount of saline water is reduced, the situation that the amount of human body fluid is excessively increased is avoided, and it is guaranteed that the saline water has the needed flushing pressure when flowing to the adsorber; and the washing effect on the adsorber is ensured.

A fixed vertical plate is fixedly connected to one end of the top of a base, guide grooves are symmetrically formed in the two sides of the fixed vertical plate, a base plate is movably installed at one end of the fixed vertical plate, and movable blocks are symmetrically and fixedly connected to one end of the base plate; hydraulic telescopic rods are symmetrically and fixedly mounted in the middle of the top end of the base, an extension plate is fixedly connected to one end of the base, and elastic buffer plates are fixedly mounted at the top end of the extension plate at equal intervals. Lying is not needed during lower limb deep vein thrombosis detection, operation is more convenient, the time needed for lying down and standing up is shortened, meanwhile, the height of the base plate can be adjusted, the height of the base plate is matched with the height and the leg length of a patient, the lower limbs of the patient can be smoothly placed on the pedal, and the patient is more convenient to use. And the medical staff can conveniently examine the patient.

The utility model discloses a bleeding expelling and stopping ring with a fixing support, and relates to the technical field of medical instruments. The hemostasis device comprises a hemostasis ring and a fixing support, one end of the fixing support is detachably and fixedly connected with the hemostasis ring, and the other end of the fixing support is detachably and fixedly connected with a diseased limb. The elastic contraction ring and the bleeding stopping ring are arranged and can be tightly attached to the diseased limb, the uniform and lasting bleeding stopping effect is achieved, complications caused by a conventional air pressure tourniquet are reduced, and the occurrence of lower limb deep vein thrombosis is reduced; the rod-rod fixing clamp is arranged, the angle and the position of the support can be adjusted according to the operation requirement and the change of the body position of the patient, and therefore the accurate control over the operation body position of the patient is achieved; the bleeding expelling and stopping ring and the fixing support are connected and combined for use, so that the risk that the operation operable area range is possibly reduced and the operation difficulty is increased when one end close to the operation part is fixed through an external support is avoided, and the operation success rate is increased.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention discloses a method for establishing a dimensionality reduction training model of a high-dimensional raman spectrum in noninvasive detection, which is a method for performing dimensionality reduction training on high-dimensional spectral data to low-dimensional characteristic peak data, and comprises the following steps of: acquiring a Raman spectrum and a test result while acquiring venous blood of a human body for test to obtain an original data set, and eliminating abnormal spectrums through t test and Z test to obtain a dimensionality reduction training model of the high-dimensional raman spectrum in noninvasive detection. The method comprises the following steps: performing baseline correction on spectral data through a least square method, eliminating noise in a spectrum through discrete wavelet transform, and performing screening, wavelet method, recursive method and verification on a pre-characteristic peak to realize dynamic dimension reduction so as to generate a pre-training data set; according to the method, the problems that traditional characteristic peak selection is inaccurate, equipment system errors are uncertain, mixed substance characteristic peaks are superposed, dynamic characteristic peak optimization is not supported and the like are solved, continuous optimization of the accuracy of the characteristic peaks in iteration can be realized, and an innovative result and a basis are provided for later quantitative measurement of the mixed substances.

The invention relates to the field of blood taking needle production equipment, in particular to vein blood taking needle automatic assembling equipment with a safety seat, which comprises a rack, a turntable and a plurality of carriers arranged on the turntable, the feeding station, the assembling station, the pressing station, the heat sealing station, the detecting station and the discharging station are sequentially arranged around the rotating disc and correspond to the carriers in position. According to the equipment, a plurality of stations are arranged and matched with the rotating disc and the carrier, automatic feeding, assembling, heat sealing, detecting and discharging of the blood taking needles with the needle wings and the safety seats are achieved, all the stations are harmoniously matched through cooperation of the clamping jaws, the clamping seats and all the air cylinders, the actions of clamping, placing and moving of the blood taking needles and all components of the blood taking needles are flexible, and the working efficiency is improved. The whole process is full-automatically and efficiently completed, excessive manual intervention is not needed, the labor cost is saved, the assembling efficiency is improved, and meanwhile foreign matter mixing in the assembling process is avoided.

The invention provides a patch type thrombus monitoring and NO release closed-loop system for treating venous thrombosis, which comprises a flexible patch substrate on which a sensor module is integrated, and the sensor module comprises a blood flow velocity sensor, a biological impedance sensor, an acceleration sensor and a temperature sensor, the acquisition units are respectively used for acquiring blood flow velocity v at a target vein, related parameters of vascular resistance R, limb movement states and skin temperature of a patch area; the NO release module is used for releasing NO to act on the venous thrombosis part; the control module comprises a signal processing unit and a control unit and is used for receiving the signal output by the sensor module and operating a closed-loop control algorithm to generate an NO release control instruction; and the power supply module provides electric energy for the sensor module, the control module and the NO release module. The invention provides a patch type closed-loop system which integrates thrombus multi-mode monitoring, decision making, NO release assisting and treatment mode self-adaptive switching.

The utility model provides an ankle pump movement device for preventing lower limb deep venous thrombosis, which relates to the technical field of medical training and comprises a base and a pedal, a rotating shaft for controlling the pedal to rotate is arranged outside the base, and the pedal is arranged outside a support frame. A fixed adjusting mechanism used for adjusting the axis position of the supporting frame is arranged outside the rotating shaft, and the fixed adjusting mechanism comprises fixed plates symmetrically arranged outside the rotating shaft; through the arrangement of the gravity block, the control push plate, the control spring and the toe plate, a user can normally step on the foot when stepping on the foot. When the user hooks the feet, the toe plate can assist in completing upward hooking of tiptoes at the maximum angle, tibia anterior muscles can contract and become short, and triceps calf muscles can relax and extend, muscle contraction and relaxation are alternately carried out, blood and lymph backflow can be squeezed like a pump, and meanwhile, when the muscles are relaxed, the user can feel comfortable when hooking the feet. And fresh blood can be supplemented, so that a better exercise effect is achieved.

The invention discloses a method, a device, equipment, a medium and a product for determining hemodynamic indexes of a blood circulation system under the action of an acceleration field, and relates to the technical field of hemodynamics, the method comprises the following steps: constructing a one-dimensional topological model and a 0-dimensional connection model of main artery and vein blood vessel networks, and assigning parameters to obtain a 0-1-dimensional coupling basic model; iteratively solving by combining the simplified model of the basic model, the objective function and the physiological measured data to obtain individualized model parameters of the subject, and assigning the individualized model parameters to the basic model; extracting geometric topology information of the blood vessel network of the concerned part based on iconography information and assigning the geometric topology information to a corresponding position of the 0-1-dimensional model; the acceleration equivalent to the real environment is applied, the individualized 0-1-dimensional model control equation of the subject is solved, the hemodynamic indexes of the blood circulation system under the action of the acceleration field are obtained, and the hemodynamic changes of the arteriovenous system and the blood supply conditions of all important organs of the subject under the action of the acceleration can be accurately and quantitatively evaluated.

Systems and methods are provided for removal of clot material from a treatment site in a blood vessel, particularly in venous vasculature. A treatment device (101) can include a core member (115) having a distal portion (109) and an inner coil (111) surrounding the distal portion of the core member. A helical outer member (113) surrounds at least a portion of the inner coil, and a sheet of flexible material (117) extends between the inner coil and the helical outer member, such that the sheet extends helically around the inner coil to provide a surface for clot engagement at the treatment site.

The invention discloses an efficient variable-pressure blood sampling device suitable for plateau regions, and relates to the technical field of vein blood sampling, the efficient variable-pressure blood sampling device comprises a base, a test tube supporting mechanism, a blood sampling needle mechanism and a piston column labor-saving drawing mechanism, the right side of the top of the base is provided with a mounting groove, and the test tube supporting mechanism is mounted on the rear side of the top of the base; a negative pressure blood sampling test tube is mounted on the test tube supporting mechanism; one end of the blood taking needle mechanism is inserted into the top of the negative pressure blood taking test tube, the blood taking needle mechanism is connected with the test tube negative pressure enhancing mechanism, and the test tube negative pressure enhancing mechanism is mounted in the mounting groove; and the labor-saving piston plunger drawing mechanism is mounted on the base at the front end of the mounting groove, and is connected with the front end of the test tube negative pressure enhancing mechanism. According to the efficient variable-pressure blood sampling device suitable for the plateau area, the negative pressure in the test tube body can be increased so as to adapt to patients with increased blood viscosity in the plateau area, and the blood sampling efficiency of venous blood can be improved.

The utility model discloses an intelligent ankle pump movement massage instrument which comprises a control instrument, two air pressure leg sleeves, a connecting part used for connecting the control instrument and the air pressure leg sleeves, a rotating motor arranged on the air pressure leg sleeves, a rotating frame connected with the output end of the rotating motor and a mounting frame arranged on the rotating frame. The device comprises a mounting frame, a driving part located on the mounting frame, a foot boot connected with the driving part, and a massager and a heater arranged on the foot boot, the device can massage the foot sole of a patient and heat the foot of the patient at the same time through the arranged massager, and during operation, in combination with foot sole massage, meridian conditioning and constant-temperature heating can be achieved, so that the patient feels comfortable; meanwhile, blood circulation is further promoted; meanwhile, limb injury caused by dysphoria of the patient can be prevented through the air bag arranged in the air pressure leg sleeve, the femoral vein blood flow peak velocity is increased through the lower limb muscle pump combined with the negative pressure effect of the thoracic cavity, the lower limb vein blood return volume is increased, and lower limb deep vein thrombosis is effectively prevented.

The invention provides a limb thrombus monitoring device and method based on arteriovenous recognition, and the device comprises a monitoring management middle platform, a multi-modal data collection module, a vein recognition module, a feature extraction module, and a risk assessment module. The monitoring management middle platform is connected with the multi-modal data acquisition module, the vein recognition module, the feature extraction module and the risk assessment module, and manages each unit; the multi-modal data acquisition module is used for acquiring image data of limb parts of a patient; and the vein recognition module is used for recognizing and positioning the limb vein position of the patient based on the near-infrared imaging data to obtain vein position information. The accuracy of thrombus monitoring, evaluation and judgment can be improved, and the problem that the thrombus monitoring process mainly depends on clinical experience of medical staff for judgment is avoided. Therefore, the thrombus monitoring and judging efficiency and accuracy are improved.

The invention provides autologous platelet-containing plasma gel and a preparation method and application thereof, and relates to the technical field of biological medicine and tissue engineering.The preparation method comprises the following steps that peripheral venous blood of a patient is extracted and added into a centrifugal tube mixed with a sodium citrate anticoagulant; putting the centrifugal tube into a centrifugal machine for centrifuging, and taking upper-layer plasma; wherein the upper-layer plasma refers to plasma between the upper-layer liquid level and the lower-layer red blood cell layer by 1mm; the centrifugal speed ranges from 1300 r / min to 1700 r / min; the centrifugation time is 3-5 min; under a sterile condition, preparing a calcium gluconate / thrombin mixed solution; and dropping the calcium gluconate / thrombin mixed solution into the upper plasma, mixing, and solidifying to obtain the autologous platelet-containing plasma gel. After one-time centrifugation, upper-layer full-layer plasma is extracted, the volume of the prepared gel is far larger than that of a traditional method, the utilization rate of whole blood platelets and fibrinogen is close to 100%, and regeneration and repair of large-area tissue wounds can be met.

The invention discloses a vein blood vessel image processing method and device, equipment and a storage medium. The vein blood vessel image processing method comprises the steps of collecting a vein blood vessel image; the collected vein blood vessel image is preprocessed; an improved U-Net segmentation network and an improved Zhang-Suen skeletonization algorithm are adopted to process the preprocessed image, and multi-modal results are fused to obtain a blood vessel segmentation result; and based on a blood vessel segmentation result, performing blood vessel three-dimensional modeling by adopting a multi-stage B-spline mapping method, and quantitatively analyzing blood vessel spatial geometric features and hemodynamic parameters to obtain a blood vessel form-function joint evaluation index. The vein blood vessel image is processed and analyzed, three-dimensional modeling is carried out on the blood vessel, the radiation path of radiotherapy is planned, and a foundation is laid for follow-up treatment of varicosity through in-vitro radiation.

The invention discloses a wearable device for preventing formation of lower limb venous thrombosis, relates to the technical field of venous thrombosis protection equipment, and provides the following scheme that the wearable device comprises a thigh clamping sleeve, and a shank clamping sleeve is arranged below the thigh clamping sleeve; knee joint driving parts are fixedly connected to the right side surfaces of the thigh clamping sleeve and the shank clamping sleeve, and 2-3 vein restraint straps are arranged on the rear side surface of the shank clamping sleeve. The upper clamping sleeve and the lower clamping sleeve are arranged to wrap the thigh and the shank, and the knee joint driving component is used for driving the two clamping sleeves to rotate mutually in an electric and gear transmission mode, so that bending between the thigh and the shank is assisted, blood circulation of the leg is assisted, and venous thrombosis is prevented; in addition, the vein restraint strap is arranged on the shank part, the binding force of the shank part is gradually reduced from bottom to top in the mode of expanding the strip-shaped air bag, and therefore flowing of blood in veins is accelerated.

Disclosed and described herein are systems, methods and device for providing simultaneous non-invasive arterial and venous oxygen saturation. An ultra-thin and self-adherable optical electronic tattoo measures blood absorbance changes from multiple locations. Another sensor may be included to provide self-calibration. Using algorithms, the signals from the blood from the artery and vein can be better separated and yield accurate blood oxygen assessments.

The present invention discloses the application of TMPRSS9 gene in the diagnosis and treatment of venous thromboembolism, and belongs to the field of medical diagnosis and treatment technology. The present invention verifies the association between missense mutations of TMPRSS9 gene and thrombophilia in human population, in vivo and in vitro, and draws the following conclusions: nonsense mutations and missense mutations at the sites of c.334C>T, c.692C>T, c.917G>A, and c.1709C>T of TMPRSS9 gene are representative in the effect of TMPRSS9 gene mutation on the occurrence of venous thrombosis. The discovery of the above-mentioned pathogenic gene mutations can prevent and treat thrombophilia at an early stage, which is of great significance for the diagnosis, treatment and management of thrombophilia. At the same time, the inclusion of the new TMPRSS9 gene enriches the genetic variation spectrum of venous thromboembolic diseases, which is of guiding significance for the screening of diseases.

The invention discloses an extravascular stent, and relates to the technical field of medical instruments. The extravascular stent comprises a first sleeve joint piece, a second sleeve joint piece and a third sleeve joint piece, the first sleeving piece is suitable for being arranged on the periphery of a vein in a sleeving mode, a plurality of deformation grooves are formed in the first sleeving piece, the area between every two adjacent deformation grooves is hollowed out, and the deformation grooves are used for enabling the first sleeving piece to adapt to the diameter change of the vein; the second sleeving piece is connected with one side of the second end of the first sleeving piece, and the second sleeving piece is suitable for being connected to the periphery of the artery blood vessel on the upstream side in a sleeving mode; the third sleeving piece is connected with the other side of the second end of the first sleeving piece, and the third sleeving piece is suitable for being connected to the periphery of the artery blood vessel on the downstream side in a sleeving mode. According to the extravascular stent provided by the invention, the structural design is improved, the mounting convenience of the extravascular stent is improved, the operation time is shortened, the adaptability of the extravascular stent to the diameter change of a vein is improved, the material cost is saved, and the treatment cost is reduced.

The utility model discloses a vein hemostat. The vein hemostat comprises a main body and an air bag, the main body is annular, and an accommodating space for allowing the arm of a person needing hemostasis to penetrate through is formed in the inner side; the air bag is arranged on the inner side of the body and used for being connected with the inflation device, the air bag is inflated through the inflation device to press the arm to block vein blood flow, and a tourniquet clamping groove is formed in the inner side of the air bag and used for allowing a disposable tourniquet to be inserted in so that the disposable tourniquet can be attached to the skin surface of the arm. According to the vein hemostat, the body and the air bag are arranged, the air bag is inflated to press the arm to block vein blood flow, the tourniquet clamping groove is formed in the inner side of the air bag and used for allowing the disposable tourniquet to be inserted, the disposable tourniquet is made to be attached to the skin surface of the arm, and therefore the discomfort brought to the arm of a person needing hemostasis due to the strength factor of a nurse can be reduced; and a disposable tourniquet can be used, so that one person can use the tourniquet, and the safety requirement of medical supplies is met.

The invention discloses a vein blood oxygen saturation real-time measurement system and method based on an LED light source. The method comprises the steps that 1, a pulse driving circuit outputs pulse voltage to drive LEDs with different wavelengths in a dual-wavelength LED light source to flicker alternately; collecting a photoacoustic signal by an ultrasonic transducer; 2, the ultrasonic signal processing platform receives the collected sound signals and carries out subsequent processing; 3, controlling the ultrasonic transducer to transmit an ultrasonic signal to the same measured part, and receiving an echo signal of the ultrasonic transducer; reconstructing an ultrasonic image of the measured part based on the echo signal; step 4, in the obtained ultrasonic image, positioning a vein to be analyzed and an adjacent artery thereof, and positioning the vein in the ultrasonic image; 5, the arterial oxygen saturation value of the whole body is measured through a finger clamping type pulse oximeter, and quantitative calculation of the venous oxygen saturation is achieved; and step 6, carrying out pixel-level fusion on the oxyhemoglobin saturation information and the ultrasonic image, and realizing visualization on the same frame of ultrasonic image.

A device may include a control element coupled to a valve disposed in an outer frame. The control element is configured to manipulate the valve between an unrestricted blood flow state and a restricted blood flow state. A device may include an actuation device including a linear actuator coupled to a control element of an implantable device, and a first magnet configured to induce rotation of the linear actuator. A control device communicatively coupled to the linear actuator includes a second magnet configured to generate a changing magnetic field pole direction to cause rotation of the first magnet either to tension the control element to position a valve of the implantable device in a restricted blood flow state or to release tension in the control element to position the valve in an unrestricted blood flow state.

The utility model relates to the technical field of medical instruments, in particular to a pacemaker electrode wire, which comprises a wire conduit, the wire conduit comprises a head part and a tail part which are connected with each other, the head part is provided with an electrode assembly, and the electrode assembly comprises a first electrode and a second electrode which are electrically connected with each other. The first electrode and the second electrode are arranged in a spaced mode in the direction from the head to the tail, and a fixing piece located between the first electrode and the second electrode is arranged on the outer side of the wire conduit. The head of the wire conduit can be sent to the right ventricular apex of the heart of a patient through vein puncture, and the fixing piece is in contact with and fixed to the surface of the endocardium, so that the first electrode is firmly fixed to the right ventricular apex, the electrode wire is kept stable in the heart of the patient, and the electrode wire is prevented from shifting or falling off; and the normal cardiac function of the patient is ensured.

The invention discloses a construction method of a human microglial cell model carrying ENTPD1 gene mutation, and the human microglial cell model is prepared by the following steps: extracting PBMC from venous blood of a hereditary spasmodic paraplegia patient, then electrically transforming four factors of Oct4, Sox2, Klf4 and cMyc, and culturing in a Matrigel-coated culture dish for 15-20 days to obtain induced pluripotent stem cells; the induced pluripotent stem cells can form a unique human microglial cell model, and the human microglial cell model and the induced pluripotent stem cells are co-cultured to obtain an organoid, so that the analysis of a pathogenic molecular mechanism behind a disease risk gene is greatly facilitated, the defects of a rodent-derived microglial cell model are complemented, and the development of the rodent-derived microglial cell model is promoted. And the influence of the ENTPD1 on the related functions of the microglial cells is further discussed.

The invention discloses a full-automatic venipuncture guiding method and system based on an AI image, and relates to the technical field of medical treatment.The method comprises the steps that an ultrasonic sensor is adopted as an imaging device, and real-time vein blood vessel images of a venipuncture area of an arm of a patient are collected in real time; sending the vein real-time image to an image processing system; processing the vein real-time image by adopting an image processing system and utilizing a first AI image processing model so as to determine a plurality of cross section vein features and a plurality of longitudinal section vein features; using a multi-axis robot to drive an ultrasonic sensor to move to a target puncture vein position; acquiring a real-time vein cross section image of a target vein segment corresponding to the target puncture vein position in real time; rendering the real-time vein cross section image into a real-time vein visual image capable of simulating the dynamic state of blood flow by adopting an image processing system and utilizing a third AI image processing algorithm; and an auxiliary puncture display is adopted to display a real-time vein visual image in real time.