436 results about "Venous blood" patented technology

The invention relates to the technical field of medical clinical auxiliary diagnosis, in particular to an orthopedic postoperative complication early detection and early warning system based on data analysis, which comprises a multi-modal sign synchronous acquisition module, a sign dynamic difference quantification module, a complication feature association module, a grading early warning decision module and a dissection calibration visualization module. Wherein the multi-modal sign synchronous acquisition module is used for acquiring postoperative data of a patient; calculating a difference quantization parameter; the complication characteristic association module is used for identifying associated risk characteristics of the osteofascia ventricular syndrome, the deep venous thrombosis and the fat embolism; and the grading early warning decision module is used for generating a three-level early warning instruction based on the associated risk characteristics. According to the system and the method, through a multi-modal sign synchronous acquisition, difference quantification and grading early warning linkage mechanism, accurate recognition, risk grade division and visual intervention guidance of postoperative complications are realized, and the continuity of postoperative monitoring and the timeliness of early warning are improved.

The invention relates to a spontaneous cerebral hemorrhage postoperative intermuscular venous thrombosis risk prediction system based on a molecular mechanism and multi-modal data and a use method thereof, image space features are extracted through a multi-modal data level CNN to be complementary with time sequence features captured and detected by Transform, and support is provided for blood coagulation-endothelium-fibrinolysis three-channel activation degree calculation; a knowledge graph alignment module of a pathology and data level maps the cross-modal features to a unified semantic space, and corrects data conflicts with pathology time sequence constraints; and channel-space-time triple attention linkage at a space-time level is carried out, and a high-risk area is accurately marked. In a path driving layer, three-path activation degrees cooperatively adjust a dynamic time window, a single-path standard-exceeding triggering monitoring interval is shortened, and a double-path standard-exceeding amplitude is multiplied; and in a closed-loop feedback layer, system parameters are updated through confidence, pathological probability and conflict signal recursion, real-time calibration of a pathological mechanism and data is realized, and thrombus risk prevention and control efficiency is comprehensively improved.

The invention discloses a venous thrombosis risk assessment method based on a large language model, and relates to the technical field of medical artificial intelligence, and the method comprises the steps: collecting thoracic surgery diagnosis and treatment data of a patient, carrying out the space-time alignment, generating a standard diagnosis and treatment data flow, and carrying out the homomorphic encryption of the standard diagnosis and treatment data flow, and forming an encrypted patient data package; inputting the encrypted patient data packet into a multi-task large language model, performing feature extraction and semantic coding by a feature coding layer, performing time sequence modeling and risk probability calculation by a risk quantification layer, and outputting a venous thromboembolism risk level of a patient; and performing feature decoupling and potential space mapping on the encrypted patient data packet to obtain thrombus semantic potential features. Through the multi-task large language model, the dual machine learning algorithm and the homomorphic encryption, the accuracy of venous thrombosis risk early warning is improved, and the safety of the risk assessment process is enhanced.

The embodiment of the invention provides a continuous blood oxygen monitoring system in extracorporeal circulation and a control method thereof. The continuous blood oxygen monitoring system comprises a vein sensor, an artery sensor, a blood flow sensor, an oxygen sensor, a carbon dioxide sensor, a controller and a display, the vein sensor monitors the vein blood oxygen saturation degree; the artery sensor monitors arterial oxygen saturation and hematocrit; the blood flow sensor monitors the blood flow of the artery pipeline; the oxygen sensor monitors the oxygen concentration of the oxygenator; the carbon dioxide sensor monitors the carbon dioxide concentration of the oxygenator; the display provides an interaction control, responds to a trigger operation acting on the interaction control, sends an interaction instruction to the controller, and updates information displayed in an interaction interface according to the control of the controller; the controller receives the interaction instruction and executes processing corresponding to the interaction instruction; the processing includes controlling display information of the display; the display information comprises information corresponding to the monitoring parameters. The scheme ensures the safety and effectiveness of the treatment process.

A fixed vertical plate is fixedly connected to one end of the top of a base, guide grooves are symmetrically formed in the two sides of the fixed vertical plate, a base plate is movably installed at one end of the fixed vertical plate, and movable blocks are symmetrically and fixedly connected to one end of the base plate; hydraulic telescopic rods are symmetrically and fixedly mounted in the middle of the top end of the base, an extension plate is fixedly connected to one end of the base, and elastic buffer plates are fixedly mounted at the top end of the extension plate at equal intervals. Lying is not needed during lower limb deep vein thrombosis detection, operation is more convenient, the time needed for lying down and standing up is shortened, meanwhile, the height of the base plate can be adjusted, the height of the base plate is matched with the height and the leg length of a patient, the lower limbs of the patient can be smoothly placed on the pedal, and the patient is more convenient to use. And the medical staff can conveniently examine the patient.

The utility model discloses a bleeding expelling and stopping ring with a fixing support, and relates to the technical field of medical instruments. The hemostasis device comprises a hemostasis ring and a fixing support, one end of the fixing support is detachably and fixedly connected with the hemostasis ring, and the other end of the fixing support is detachably and fixedly connected with a diseased limb. The elastic contraction ring and the bleeding stopping ring are arranged and can be tightly attached to the diseased limb, the uniform and lasting bleeding stopping effect is achieved, complications caused by a conventional air pressure tourniquet are reduced, and the occurrence of lower limb deep vein thrombosis is reduced; the rod-rod fixing clamp is arranged, the angle and the position of the support can be adjusted according to the operation requirement and the change of the body position of the patient, and therefore the accurate control over the operation body position of the patient is achieved; the bleeding expelling and stopping ring and the fixing support are connected and combined for use, so that the risk that the operation operable area range is possibly reduced and the operation difficulty is increased when one end close to the operation part is fixed through an external support is avoided, and the operation success rate is increased.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention discloses a method for establishing a dimensionality reduction training model of a high-dimensional raman spectrum in noninvasive detection, which is a method for performing dimensionality reduction training on high-dimensional spectral data to low-dimensional characteristic peak data, and comprises the following steps of: acquiring a Raman spectrum and a test result while acquiring venous blood of a human body for test to obtain an original data set, and eliminating abnormal spectrums through t test and Z test to obtain a dimensionality reduction training model of the high-dimensional raman spectrum in noninvasive detection. The method comprises the following steps: performing baseline correction on spectral data through a least square method, eliminating noise in a spectrum through discrete wavelet transform, and performing screening, wavelet method, recursive method and verification on a pre-characteristic peak to realize dynamic dimension reduction so as to generate a pre-training data set; according to the method, the problems that traditional characteristic peak selection is inaccurate, equipment system errors are uncertain, mixed substance characteristic peaks are superposed, dynamic characteristic peak optimization is not supported and the like are solved, continuous optimization of the accuracy of the characteristic peaks in iteration can be realized, and an innovative result and a basis are provided for later quantitative measurement of the mixed substances.

The invention provides a patch type thrombus monitoring and NO release closed-loop system for treating venous thrombosis, which comprises a flexible patch substrate on which a sensor module is integrated, and the sensor module comprises a blood flow velocity sensor, a biological impedance sensor, an acceleration sensor and a temperature sensor, the acquisition units are respectively used for acquiring blood flow velocity v at a target vein, related parameters of vascular resistance R, limb movement states and skin temperature of a patch area; the NO release module is used for releasing NO to act on the venous thrombosis part; the control module comprises a signal processing unit and a control unit and is used for receiving the signal output by the sensor module and operating a closed-loop control algorithm to generate an NO release control instruction; and the power supply module provides electric energy for the sensor module, the control module and the NO release module. The invention provides a patch type closed-loop system which integrates thrombus multi-mode monitoring, decision making, NO release assisting and treatment mode self-adaptive switching.

Systems and methods are provided for removal of clot material from a treatment site in a blood vessel, particularly in venous vasculature. A treatment device (101) can include a core member (115) having a distal portion (109) and an inner coil (111) surrounding the distal portion of the core member. A helical outer member (113) surrounds at least a portion of the inner coil, and a sheet of flexible material (117) extends between the inner coil and the helical outer member, such that the sheet extends helically around the inner coil to provide a surface for clot engagement at the treatment site.

The invention discloses an efficient variable-pressure blood sampling device suitable for plateau regions, and relates to the technical field of vein blood sampling, the efficient variable-pressure blood sampling device comprises a base, a test tube supporting mechanism, a blood sampling needle mechanism and a piston column labor-saving drawing mechanism, the right side of the top of the base is provided with a mounting groove, and the test tube supporting mechanism is mounted on the rear side of the top of the base; a negative pressure blood sampling test tube is mounted on the test tube supporting mechanism; one end of the blood taking needle mechanism is inserted into the top of the negative pressure blood taking test tube, the blood taking needle mechanism is connected with the test tube negative pressure enhancing mechanism, and the test tube negative pressure enhancing mechanism is mounted in the mounting groove; and the labor-saving piston plunger drawing mechanism is mounted on the base at the front end of the mounting groove, and is connected with the front end of the test tube negative pressure enhancing mechanism. According to the efficient variable-pressure blood sampling device suitable for the plateau area, the negative pressure in the test tube body can be increased so as to adapt to patients with increased blood viscosity in the plateau area, and the blood sampling efficiency of venous blood can be improved.

The invention provides a limb thrombus monitoring device and method based on arteriovenous recognition, and the device comprises a monitoring management middle platform, a multi-modal data collection module, a vein recognition module, a feature extraction module, and a risk assessment module. The monitoring management middle platform is connected with the multi-modal data acquisition module, the vein recognition module, the feature extraction module and the risk assessment module, and manages each unit; the multi-modal data acquisition module is used for acquiring image data of limb parts of a patient; and the vein recognition module is used for recognizing and positioning the limb vein position of the patient based on the near-infrared imaging data to obtain vein position information. The accuracy of thrombus monitoring, evaluation and judgment can be improved, and the problem that the thrombus monitoring process mainly depends on clinical experience of medical staff for judgment is avoided. Therefore, the thrombus monitoring and judging efficiency and accuracy are improved.

The invention provides autologous platelet-containing plasma gel and a preparation method and application thereof, and relates to the technical field of biological medicine and tissue engineering.The preparation method comprises the following steps that peripheral venous blood of a patient is extracted and added into a centrifugal tube mixed with a sodium citrate anticoagulant; putting the centrifugal tube into a centrifugal machine for centrifuging, and taking upper-layer plasma; wherein the upper-layer plasma refers to plasma between the upper-layer liquid level and the lower-layer red blood cell layer by 1mm; the centrifugal speed ranges from 1300 r / min to 1700 r / min; the centrifugation time is 3-5 min; under a sterile condition, preparing a calcium gluconate / thrombin mixed solution; and dropping the calcium gluconate / thrombin mixed solution into the upper plasma, mixing, and solidifying to obtain the autologous platelet-containing plasma gel. After one-time centrifugation, upper-layer full-layer plasma is extracted, the volume of the prepared gel is far larger than that of a traditional method, the utilization rate of whole blood platelets and fibrinogen is close to 100%, and regeneration and repair of large-area tissue wounds can be met.

The invention discloses a vein blood vessel image processing method and device, equipment and a storage medium. The vein blood vessel image processing method comprises the steps of collecting a vein blood vessel image; the collected vein blood vessel image is preprocessed; an improved U-Net segmentation network and an improved Zhang-Suen skeletonization algorithm are adopted to process the preprocessed image, and multi-modal results are fused to obtain a blood vessel segmentation result; and based on a blood vessel segmentation result, performing blood vessel three-dimensional modeling by adopting a multi-stage B-spline mapping method, and quantitatively analyzing blood vessel spatial geometric features and hemodynamic parameters to obtain a blood vessel form-function joint evaluation index. The vein blood vessel image is processed and analyzed, three-dimensional modeling is carried out on the blood vessel, the radiation path of radiotherapy is planned, and a foundation is laid for follow-up treatment of varicosity through in-vitro radiation.

The present invention discloses the application of TMPRSS9 gene in the diagnosis and treatment of venous thromboembolism, and belongs to the field of medical diagnosis and treatment technology. The present invention verifies the association between missense mutations of TMPRSS9 gene and thrombophilia in human population, in vivo and in vitro, and draws the following conclusions: nonsense mutations and missense mutations at the sites of c.334C>T, c.692C>T, c.917G>A, and c.1709C>T of TMPRSS9 gene are representative in the effect of TMPRSS9 gene mutation on the occurrence of venous thrombosis. The discovery of the above-mentioned pathogenic gene mutations can prevent and treat thrombophilia at an early stage, which is of great significance for the diagnosis, treatment and management of thrombophilia. At the same time, the inclusion of the new TMPRSS9 gene enriches the genetic variation spectrum of venous thromboembolic diseases, which is of guiding significance for the screening of diseases.

The invention discloses an extravascular stent, and relates to the technical field of medical instruments. The extravascular stent comprises a first sleeve joint piece, a second sleeve joint piece and a third sleeve joint piece, the first sleeving piece is suitable for being arranged on the periphery of a vein in a sleeving mode, a plurality of deformation grooves are formed in the first sleeving piece, the area between every two adjacent deformation grooves is hollowed out, and the deformation grooves are used for enabling the first sleeving piece to adapt to the diameter change of the vein; the second sleeving piece is connected with one side of the second end of the first sleeving piece, and the second sleeving piece is suitable for being connected to the periphery of the artery blood vessel on the upstream side in a sleeving mode; the third sleeving piece is connected with the other side of the second end of the first sleeving piece, and the third sleeving piece is suitable for being connected to the periphery of the artery blood vessel on the downstream side in a sleeving mode. According to the extravascular stent provided by the invention, the structural design is improved, the mounting convenience of the extravascular stent is improved, the operation time is shortened, the adaptability of the extravascular stent to the diameter change of a vein is improved, the material cost is saved, and the treatment cost is reduced.

The invention discloses a vein blood oxygen saturation real-time measurement system and method based on an LED light source. The method comprises the steps that 1, a pulse driving circuit outputs pulse voltage to drive LEDs with different wavelengths in a dual-wavelength LED light source to flicker alternately; collecting a photoacoustic signal by an ultrasonic transducer; 2, the ultrasonic signal processing platform receives the collected sound signals and carries out subsequent processing; 3, controlling the ultrasonic transducer to transmit an ultrasonic signal to the same measured part, and receiving an echo signal of the ultrasonic transducer; reconstructing an ultrasonic image of the measured part based on the echo signal; step 4, in the obtained ultrasonic image, positioning a vein to be analyzed and an adjacent artery thereof, and positioning the vein in the ultrasonic image; 5, the arterial oxygen saturation value of the whole body is measured through a finger clamping type pulse oximeter, and quantitative calculation of the venous oxygen saturation is achieved; and step 6, carrying out pixel-level fusion on the oxyhemoglobin saturation information and the ultrasonic image, and realizing visualization on the same frame of ultrasonic image.

A device may include a control element coupled to a valve disposed in an outer frame. The control element is configured to manipulate the valve between an unrestricted blood flow state and a restricted blood flow state. A device may include an actuation device including a linear actuator coupled to a control element of an implantable device, and a first magnet configured to induce rotation of the linear actuator. A control device communicatively coupled to the linear actuator includes a second magnet configured to generate a changing magnetic field pole direction to cause rotation of the first magnet either to tension the control element to position a valve of the implantable device in a restricted blood flow state or to release tension in the control element to position the valve in an unrestricted blood flow state.

The utility model relates to the technical field of medical instruments, in particular to a pacemaker electrode wire, which comprises a wire conduit, the wire conduit comprises a head part and a tail part which are connected with each other, the head part is provided with an electrode assembly, and the electrode assembly comprises a first electrode and a second electrode which are electrically connected with each other. The first electrode and the second electrode are arranged in a spaced mode in the direction from the head to the tail, and a fixing piece located between the first electrode and the second electrode is arranged on the outer side of the wire conduit. The head of the wire conduit can be sent to the right ventricular apex of the heart of a patient through vein puncture, and the fixing piece is in contact with and fixed to the surface of the endocardium, so that the first electrode is firmly fixed to the right ventricular apex, the electrode wire is kept stable in the heart of the patient, and the electrode wire is prevented from shifting or falling off; and the normal cardiac function of the patient is ensured.

The invention discloses a full-automatic venipuncture guiding method and system based on an AI image, and relates to the technical field of medical treatment.The method comprises the steps that an ultrasonic sensor is adopted as an imaging device, and real-time vein blood vessel images of a venipuncture area of an arm of a patient are collected in real time; sending the vein real-time image to an image processing system; processing the vein real-time image by adopting an image processing system and utilizing a first AI image processing model so as to determine a plurality of cross section vein features and a plurality of longitudinal section vein features; using a multi-axis robot to drive an ultrasonic sensor to move to a target puncture vein position; acquiring a real-time vein cross section image of a target vein segment corresponding to the target puncture vein position in real time; rendering the real-time vein cross section image into a real-time vein visual image capable of simulating the dynamic state of blood flow by adopting an image processing system and utilizing a third AI image processing algorithm; and an auxiliary puncture display is adopted to display a real-time vein visual image in real time.

The application discloses a lower limb venous thrombosis prevention training device and particularly relates to the field of training devices. The device comprises a support frame, both sides of the bottom of the support frame are provided with placing grooves, a sliding block is slidably connected to the support frame, a limiting groove is fixedly connected with the sliding block and slidably connected to the support frame, two driving racks are symmetrically arranged on the two sides of the sliding block and fixedly connected with the sliding block, two first driving gears are respectively engaged with the corresponding driving racks, each first driving gear is rotatably connected to the support frame, two flexible shoes are symmetrically arranged and each flexible shoe can be detachably connected with the limiting groove and the first driving gear, and a driving assembly can be driven by a user to move the sliding block. The application solves the problem that the existing prevention training device is not suitable for the elderly patients with insufficient muscle strength and improves the initiative of patient training.

The invention provides a stepped air bag control method for preventing venous thrombosis based on infrared detection, and relates to the technical field of medical instrument control, and the method comprises the steps: obtaining the tissue oxygen saturation of at least one monitoring point of a target limb of a target user through a near-infrared sensor; when the target user is a hemiplegic individual, determining a control parameter of the stepped air bag according to the tissue oxygen saturation, and controlling the stepped air bag worn by the target limb to work according to the control parameter, so that the tissue oxygen saturation of the target limb reaches a preset state; the tissue oxygen saturation difference value of the hemiplegic side lower limb and the healthy side lower limb of the target user is smaller than a preset balance threshold value. According to the method provided by the invention, the stepped air bag can be dynamically controlled according to the real-time blood circulation state of the individual, the suitability, the real-time performance and the safety of venous thrombosis prevention of the limbs of the paralyzed individual are improved, and the use requirements of different individuals are met.

The utility model relates to the field of massage leg sleeves, in particular to an air pressure massage leg sleeve for preventing venous thrombosis. According to the technical scheme, side edge connecting belts are arranged on the two sides of a cotton external inflation protective sleeve; the number of the side edge connecting belts is six, and three side edge connecting belts are arranged on the same side. A side edge adhesive tape is arranged at the upper end part of the side edge connecting belt; the side edge connecting belts and the side edge adhesive tapes are arranged into one group, and six groups are arranged in total and are uniformly distributed on two sides. By arranging the main body connection protection structure, adhesion type wrapping work can be conveniently conducted on the whole leg, meanwhile, the heating structure is arranged in the device to conduct internal heating, rapid blood activating work can be achieved on the leg, the venous thrombosis prevention massage efficiency can be conveniently accelerated and improved, the inflation structure is arranged at the front end of the whole device, and the inflation structure is arranged at the back end of the whole device. And finally, the movable rotating structures are arranged on the two sides of the connection inflation structure, so that the protection work of the connection inflation structure is achieved, and the practicability and comfort are enhanced.

To provide a blood purification device that can accurately determine whether a venipuncture has been performed correctly in a patient. [Solution] The blood purification device 1 comprises a blood purifier 3 capable of purifying blood, a blood circuit 2 having an arterial blood circuit 21 with an arterial puncture needle 211 attached to its tip and a venous blood circuit 22 with a venous puncture needle 221 attached to its tip, an impedance measuring unit 5 having an oscillator 53 that applies an AC voltage between an arterial electrode 51 provided on the arterial blood circuit 21 and a venous electrode 52 provided on the venous blood circuit 22, and capable of measuring the frequency characteristics of the impedance between the arterial electrode 51 and the venous electrode 52, and a puncture determination unit 72 that determines whether the patient has been properly punctured based on the measured impedance frequency characteristics, and further comprises a frequency range determination unit 70 that determines the frequency range of the AC voltage applied by the oscillator 53 according to the liquid in the blood circuit 2.

The utility model relates to the field of medical instruments, in particular to a thighbone drilling guider and a unicondylar femoral extramedullary positioning device. A guiding body of the thighbone drilling guider is used for abutting against the far end of a thighbone condyle, a first through hole and a second through hole are formed in the guiding body in the first preset direction, and the first through hole and the second through hole are both used for positioning marking lines of the center position of the thighbone condyle. At least one of the first abutting part and the second abutting part is movably connected with the guiding body in the second preset direction. The first propping part and the second propping part are respectively used for propping against the posterior condyle of the femur and the osteotomy surface of the tibia; wherein the first preset direction is perpendicular to the second preset direction. The femur drilling guider is applied to a single-condyle femur extramedullary positioning device, is used for positioning outside femur marrow, can effectively reduce intramedullary hemorrhage, reduces the blood loss amount and the blood transfusion rate of an operation, and meanwhile reduces the occurrence rate of deep venous thrombosis, pulmonary embolism and cerebral embolism in and after the operation.

The invention relates to medicine, in particular to gerontology and therapy and can be used for treating sarcopenia in elderly patients.Summary of the invention consists in alternating for 1…2 days the intravenous administration of ozonized 0.9% NaCl solution and major autohemotherapy, namely 500 mL of a 0.9% NaCl solution ozonized with an ozone-oxygen mixture, with an ozone concentration of 5…10 µg / mL, are administered, and major autohemotherapy consists in collecting 300…400 mL of venous blood from the patient, which is ozonized, with an ozone concentration of 15 µg / mL and transfused to the patient, the treatment course includes 8…10 consecutive procedures, then it is extended with minor autohemotherapy, which consists in collecting 5…10 mL of venous blood, which is ozonized, with an ozone concentration of 15 µg / mL and administered intramuscularly every 10th day of alternation and includes 3 consecutive procedures, and the ozonized 0.9% NaCl solution is administered for up to 6…8 weeks.

The utility model provides a microsurgery vascular anastomosis training operation table, which is characterized in that a fixing block protruding upwards is fixedly arranged at the left position of the top surface of a base plate, and a left plain end needle head is fixedly inserted into the fixing block from left to right; a sliding block capable of adjusting left-right transverse sliding is arranged at the position, close to the right, of the top face of the base plate, and a right plain end needle is fixedly inserted into the sliding block from right to left. The left plain-end needle and the right plain-end needle are oppositely arranged above the top face of the base plate in a left-right spaced mode, and the two ends of the simulated blood vessel are fixedly connected to needle tubes of the left plain-end needle and the right plain-end needle in a sleeved mode respectively. According to the vascular anastomosis training operation table, the simulated blood vessel can be effectively fixed, pulse water flow or constant water flow is connected to the connecting base of the right plain end needle head, and the simulated blood vessel can be used for simulating an artery blood vessel or a vein blood vessel of a living animal for vascular anastomosis training. When the blood vessel anastomosis training operation table is used for training, blood vessels of living animals do not need to be used, implementation is convenient, and skill training is carried out.

Cannula devices can be used for withdrawing venous blood from a patient and returning arterial blood to the patient after extracorporeal oxygenation. For example, this document describes dual lumen cannula devices and methods for their use with systems such as extracorporeal membrane oxygenation (ECMO) systems. The technology described herein includes a cannula device, and a methodology utilizing the cannula device, to provide complete hemodynamic support incorporating both venous drainage cannula and arterial return cannula in a single cannula device.

The invention discloses a biomarker for detecting venous thrombosis and application of the biomarker, and belongs to the technical field of molecular markers, the biomarker is ESM1, early diagnosis and positive prevention of venous thrombosis embolism can be achieved by monitoring the marker, and compared with a diagnosis method in the prior art, the biomarker has the advantages that the biomarker is simple and convenient to use. The marker provided by the invention is a plasma-derived biomarker, can avoid invasive diagnosis, is minimally invasive in sampling, is easy to detect, does not cause body injury, and does not need to use a large instrument. Meanwhile, the ESM1 and D-dimer combined detection improves the sensitivity and accuracy of the existing serological detection method (D-dimer detection) for judging thrombus, and can be used for early prevention and treatment effect evaluation of venous thrombosis.

The present invention discloses a trimer of Asn-Gly-Pro, namely [Asn-Gly-Pro]3, discloses its preparation method and its application in the treatment of venous thrombotic diseases. Experiments have proved that [Asn-Gly-Pro]3 of the present invention not only has a good anti-venous thrombosis effect, but also the anti-venous thrombosis effect is significantly stronger than that of Asn-Gly-Pro. Therefore, it is proposed that the present invention provides an effective technical means for anti-venous thrombosis.