20 results about "Human airway" patented technology

The present invention uses ex vivo human airway cultures to assess the human transmissibility and replication competence of influenza and coronavirus strains. By comparing pandemic influenza A subtype H1N1 and highly pathogenic avian influenza H5N1 as reference strains, the transmissibility risk of various viruses was evaluated and categorized. Additionally, an in vitro model evaluated virus-induced impairment of alveolar fluid clearance (AFC) as an indicator of disease severity. The study revealed correlations between bronchus viral replication, human transmission, AFC impairment, and clinical disease severity across different influenza and coronavirus strains.

The invention uses ex vivo human airway cultures to assess the transmissibility and replication ability of influenza and coronavirus strains. By comparing the pandemic influenza A H1N1 and the highly pathogenic influenza A H5N1 as reference virus strains, the spreading risks of various viruses are evaluated and classified. In addition, an in vitro model is used to assess the degree of alveolar fluid clearance (AFC) impairment caused by the virus as an indicator of the severity of the disease. The research reveals the relevance among the virus replication ability, human transmission, AFC damage degree and clinical disease severity of different influenza and coronavirus strains in bronchus.

The invention provides a breathing machine and anaesthesia machine internal pipeline bacterium sampling device, the bacterium sampling device is used in the state that the air outlet end of a breathing machine / anaesthesia machine main machine is not connected with the human airway, the bacterium sampling device comprises: an output pipeline, the inlet of which is connected with the air outlet end of the breathing machine / anaesthesia machine main machine through a quick joint; the rotary opening and closing mechanism is connected with an outlet of the output pipeline in a sleeving manner, a bacterium sampling device is fixed below the rotary opening and closing mechanism, a sampling vessel is arranged in the bacterium sampling device, and a bacterium culture medium is arranged in the sampling vessel. The bacteria sampling device for the internal pipeline of the breathing machine and the anaesthesia machine can directly collect bacteria in output gas of the breathing machine / anaesthesia machine, and the bacterial pollution condition can be found in the early stage conveniently.

A simulated airway for training and practicing medical procedures has an upper jaw having simulated teeth, a nasal passage, a tongue, an epiglottis, a larynx, a trachea, an esophagus, and vocal cords. Portions of the airway are reinforced with fabric. A method of making a human airway model for simulation of medical procedures includes sculpting a core for a mold from a resin material, depositing a layer of clay on the core, and placing the core in a mold. The layer of clay is removed and a polymer is injected into the mold.

The utility model discloses a visual intubation laryngeal mask tracheal catheter device which comprises a ventilation elbow with a mask bag, and a ventilation connector used for being connected with external air supply equipment is arranged at the end, away from the mask bag, of the ventilation elbow. A cannula cavity is formed in one side of the interior of the ventilation bent pipe, one end of the cannula cavity is communicated with the ventilation connector, and a mask back extending to the bottom of the mask bag is arranged at the end, away from the ventilation connector, of the ventilation bent pipe. The mask back is provided with a ventilation opening which is located in the mask bag and used for communicating the cannula cavity with a human body cavity, and the ventilation opening is provided with a guide boss used for guiding an external trachea cannula to enter a human body airway. The visual structure is arranged on the ventilation bent pipe and used for monitoring trachea cannula operation in the forward direction so as to enlarge the visual field range. The tracheal intubation guiding device has the advantages that tracheal intubation operation can be monitored in the forward direction to enlarge the visual field range, and a tracheal intubation can be safely guided to enter an airway.

The invention discloses a human airway inhalation particle deposition rate prediction method and system based on digital twinning, and relates to the field of auxiliary medical treatment. Acquiring a medical image of the target airway region, and establishing a digital twinborn model with dynamic response capability based on the medical image; numerical parameters of the central airway are obtained through computational fluid dynamics simulation, the numerical parameters are mapped to the digital twinborn model, and the incidence relation between the parameters and digital twinborn model features is established; training an initial TabPFN model by using a basic data set generated by the digital twinborn model; and collecting real-time respiration and particle parameters of a human body, and inputting the real-time respiration and particle parameters into the optimized TabPFN model to obtain a deposition rate result. According to the method, the accuracy and the personalized adaptation degree of deposition rate prediction are greatly improved.

The invention discloses a human airway basal stem cell culture medium as well as a preparation method and application thereof. The culture medium provided by the invention is simple in preparation method and high in safety, a culture plate does not need to be coated with a feeding layer or matrigel, and the airway basal stem cells subjected to primary culture are good in stability; after multiple passage, the normal form of the basal stem cells can be maintained, and good differentiation potential can be maintained; meanwhile, components of the culture medium are clear, and scientific research-grade and clinical-grade application of the airway basal stem cells can be met at the same time.

The invention discloses a method for evaluating potential airway epithelial toxicity of inhalable particles based on organoids, and relates to the technical field of toxicity detection. According to the method for evaluating the potential airway epithelium toxicity of the inhalable particles based on the human ciliary eversion airway organ, objective quantitative analysis on the epithelium structure (epithelium thickness) and the cell function (ciliary movement and goblet cell secretion) of the human airway is realized; a rapid and accurate evaluation method is provided for inhalation toxicity research of various types of inhalable particles.

Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly enhanced testing and characterization techniques for phototherapeutic light treatments are disclosed. Such testing and characterization techniques may be particularly useful in the evaluation and development of light-based treatments for various infectious diseases, including multiple variants of SARS-CoV-2. In particular aspects, testing and characterization techniques are related to the direct testing of differentiated tissue models of human airway epithelia that have been exposed to various pathogens. Phototherapeutic light treatments and corresponding treatment protocols for light are also described that not only inactivate SARS-COV-2 variants in cell-free suspensions, but also inhibit SARS-CoV-2 infections at multiple stages of infection in tissue models of human airway epithelia in a variant-agnostic manner.

A simulated airway for training and practicing medical procedures has an upper jaw with simulated teeth, a nasal channel, a tongue, an epiglottis, a throat, a trachea, an esophagus, and a vocal cord. The portion of the air passage is reinforced by a fabric. A method of manufacturing a human airway model for medical procedure simulation includes sculpturing a core for a mold from a resin material, depositing a layer of clay on the core, and placing the core in the mold. The clay layer is removed and the polymer is injected into the mold.

A simulated airway for training and practicing medical procedures has an upper jaw having simulated teeth, a nasal passage, a tongue, an epiglottis, a larynx, a trachea, an esophagus, and vocal cords. Portions of the airway are reinforced with fabric. A method of making a human airway model for simulation of medical procedures includes sculpting a core for a mold from a resin material, depositing a layer of clay on the core, and placing the core in a mold. The layer of clay is removed and a polymer is injected into the mold.

Described are examples of a training simulator for direct laryngoscopy, which reproduce the dynamics of the human airway and hyoid bone movement observed in the human anatomy during movement of the somatic skeleton and direct laryngoscopy procedures. Training simulators can include a skeleton structure having a styloid process analogue, a mandible analogue, and a longitudinally extending column configured to move between an extended state and a flexed state. A suspension chain can extend parallel to the column and be configured to move with the column. The suspension chain can include a hyoid analogue coupled to the styloid process analogue, the mandible analogue, and an anchor point situated along the column of the skeleton structure. Training simulators can also include a glottis analogue, the visibility of which can be greater when the column is in a flexed state, than when the column is in an extended state.

The invention discloses a serum-free culture medium and application thereof. The serum-free culture medium comprises an MCDB153 basal culture medium, a high amino acid composition and a small molecule signal channel regulator composition. According to the serum-free culture medium for fine lung slice culture of the human airway epithelial stem cells and the in-vitro lung tissue, the MCDB153 basic culture medium, the high-amino-acid composition with specific components and concentrations and the small-molecule signal channel regulator composition are adopted, the chemical components of a culture system are definite, and the stability among batches is good; the long-term subculture (gt; 15 generations), maintaining stemness and differentiation potential; the establishment of a complete three-dimensional culture and directional differentiation scheme is facilitated, and technical support is provided for disease model construction and drug screening.

Provided herein is a bottlebrush polyethylene glycol (PEG-BB) nanocarrier that can translocate across all barriers within the human airway surface.

The invention discloses an airway basal cell-N-acetylcysteine conjugate, which is prepared by the following steps: adding DMPE-PEG-maleimide and N-acetylcysteine into a solution, incubating at room temperature, and centrifuging, so as to obtain a DMPE-PEG-maleimide-N-acetylcysteine compound; and adding the DMPE-PEG-maleimde-N-acetylcysteine compound into a cell suspension of human airway basal cells, and incubating at room temperature to obtain the human airway basal cell suspension. According to the invention, DMPE-PEG-maleimide is used as a non-invasive carrier, and airway basal cells and a drug-N-acetylcysteine are coupled; during treatment, inflammatory response can be controlled while lung injury is effectively repaired, cells can play a homing role, and the medicine is carried to reside at the injured part for long-acting treatment. The research of the invention is of great significance to the treatment of pneumonia.

The utility model discloses a silica gel trachea cannula with a woven wire structure, which relates to the technical field of tracheas and comprises a silica gel main tube outer tube and a woven wire support frame, the woven wire support frame is arranged in the wall body of the silica gel main tube outer tube, a balloon is further arranged on one side of the silica gel main tube outer tube, a fixed air charging device is further connected onto the silica gel main tube outer tube, and the woven wire support frame is connected with the silica gel main tube outer tube. The woven wires are used for replacing springs, the woven wires have the same supporting performance as the springs, after one position of the silica gel main pipe is scratched or bitten to be broken, stress on the main pipe is shared by the woven wires and cannot be completely borne by the silica gel main pipe, the risk that the main pipe is broken is greatly reduced, and even if the outside of the silica gel main pipe is broken due to stress, the silica gel main pipe cannot be damaged due to connection of the woven wires. The silica gel main tube is still connected by the weaving wires, and the weaving wires are not in contact with the airway of the human body, so that the postoperative recovery difficulty of the patient is reduced.

The invention provides a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and a preparation method thereof, the preparation method comprises the following steps: weighing medicinal materials according to a formula, pretreating, and then respectively decocting concha meretricis seu cyclinae, extracting water from plants and extracting fat-soluble components with alcohol. And carrying out composite enzymolysis treatment on the extracted filter residues, extracting mineral medicines and residual components, and carrying out supercritical extraction on the active components of the cortex mori radicis. The animal medicine part is subjected to enzymolysis to improve the dissolution rate of protein components, finally, all extracting solutions are mixed and concentrated, and auxiliary materials are added to prepare granules, tablets or oral liquid. According to the whole process, by accurately controlling the temperature, the time, the pH value and the extraction mode, the extraction rate of effective components and the stability of the preparation are improved, and in-vitro experiments show that the composition inhibits LPS-induced human airway epithelial cell secretion and relieves airway inflammatory response. Experiments show that the traditional Chinese medicine composition can significantly improve the lung function of a COPD model rat and reduce alveolar interval destruction, and the effect of the traditional Chinese medicine composition is related to adjustment of an inflammatory pathway and inhibition of airway remodeling.

The present disclosure relates to the technical field of endoscopy, and provides a path planning method. In the method, a cross-sectional image of a target object and hardware parameters of a bronchoscope robot corresponding to the target object are obtained; according to the cross-sectional image of the target object, lesion feature information, trachea feature information and blood vessel feature information of the target object are determined; according to the hardware parameters of the bronchoscope robot, and the lesion feature information, the trachea feature information and the blood vessel feature information of the target object, an airway wall puncture biopsy path of the bronchoscope robot is determined. In this way, since multiple constraint conditions are considered in the generation process of the airway wall puncture biopsy path, the most efficient and safe airway wall puncture biopsy path can be obtained, thereby the problems of subjectivity and human error that occur when a scheme is artificially formulated can be avoided, and thus the airway wall puncture biopsy path obtained by the embodiment is more accurate and has more reference value, and the safety and efficiency of the puncture biopsy are also improved.

A tracheal introducer sheath device (TIS) device is disclosed for guiding the insertion of a tracheal introducer. Tracheal introducer sheath device has a hollowed tube of flexible material that provides a sheath channel for a tracheal introducer. Tracheal introducer sheath device has a proximal end and a distal end. Tracheal introducer is guided via the sheath channel from the proximal end in a controller manner to a glottic opening of a person's airway. Sheath channel in the tracheal introducer sheath device is manually moldable to articulate different angles, wherein the different angles supports the movement of the tracheal introducer deeper into a person's airway.