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6893results about "Biological material testing procedures" patented technology
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Method for separating analyte from a sample
InactiveUS6893879B2Improve elution efficiencyBioreactor/fermenter combinationsBiological substance pretreatmentsSporeChemical reaction
An analyte is separated from a fluid sample by introducing the sample into a cartridge having an extraction chamber containing capture material for capturing the analyte. The sample is forced to flow through the extraction chamber to capture the analyte with the capture material in the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber. The cartridge may optionally include a lysing region for lysing sample components (e.g., cells spores, or microorganisms), a waste chamber for storing waste fluid, and reaction or detection chambers for chemically reacting or detecting the eluted analyte.
Owner:CEPHEID INC
System for autonomous monitoring of bioagents
InactiveUS20040038385A1Bioreactor/fermenter combinationsBiological substance pretreatmentsMonitoring systemPhysics
An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means. One embodiment of the present invention includes confirmation means for confirming the bioagents in the sample.
Owner:LAWRENCE LIVERMORE NAT SECURITY LLC
Method for preparing thrombin for use in a biological glue
InactiveUS6472162B1Derive fast acting, stable autologous thrombinSimple preparatory procedureBioreactor/fermenter combinationsBiological substance pretreatmentsTissue sealantDonors plasma
A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component and the clotting and adhesive proteins component are harvested simultaneously from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
Owner:ASAHI KASEI MEDICAL CO LTD
Electrochemical device for moving particles covered with protein
InactiveUS6972080B1Efficient disposalElectrostatic separatorsSludge treatmentBlood componentElectrolysis
An electrochemical device for moving particles covered with a protein is provided. The device includes at least two electrodes that are in contact with a liquid containing the protein-covered particles and a circuit that generates a potential difference in a range that does not cause electrolysis of the liquid between the electrodes. The particles are moved by electrophoresis in the direction of the arrangement of the electrodes. The invention provided herein has numerous applications, including use in a microorganism concentration condensing device, a blood component induction device, and / or a blood component induction method, and / or an electric appliance that decreases the concentration of microorganisms present on the surface of a heat exchanger.
Owner:PANASONIC CORP
Integrated organ and tissue printing methods, system and apparatus
InactiveUS20120089238A1Additive manufacturing apparatusPretreated surfacesLiving cellBiomedical engineering
A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
Owner:KANG HYUN WOOK +3
Devices and methods for collection, storage and transportation of biological specimens
InactiveUS20050227269A1Safe and convenient and simple deviceLow costBioreactor/fermenter combinationsBiological substance pretreatmentsTarget analysisAnalyte
The present invention provides devices and methods for collecting, storing or transporting liquid suspension of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest are reconstituted and released for subsequent analysis by compressing the matrix in the device. Also provided are kits for collecting, storing, transporting and recovering biological specimens containing analytes of interest.
Owner:VIVEBIO
Architecture tool and methods of use
InactiveUS7857756B2Additive manufacturing apparatusLiquid surface applicatorsTemperature controlMedicine
The invention provides an apparatus and methods for depositing materials on a substrate, and for performing other selected functions, such as material destruction and removal, temperature control, imaging, detection, therapy and positional and locational control. In various embodiments, the apparatus and methods are suitable for use in a tabletop setting, in vitro or in vivo.
Owner:SCIPERIO
Perfused three-dimensional cell/tissue disease models
ActiveUS20050260745A1Easy to primeBioreactor/fermenter combinationsBiological substance pretreatmentsLymphatic SpreadPathology diagnosis
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
Owner:MASSACHUSETTS INST OF TECH +1
Device and method for the detection of an analyte utilizing mesoscale flow systems
InactiveUS7005292B2Quick testEasy to disinfectBioreactor/fermenter combinationsHeating or cooling apparatusAnalyteChemistry
Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Barriers for facilitating biological reactions
ActiveUS20090246782A1Prevent or reduce the loss of liquid during handling or useBioreactor/fermenter combinationsBiological substance pretreatmentsAnalytical chemistryBiological reaction
Owner:NORTHWESTERN UNIV
Method and apparatus for spatially confined electroporation
InactiveUS20050048651A1Bioreactor/fermenter combinationsElectrotherapyBiological targetElectroporation
The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and / or cells. The invention also provides electrode plates for receiving one or more of such tips, tip-electrode plates comprising electrode plates comprising one or more electrode tips, and systems comprising tip-electrodes and containers for containing one or more biological targets, e.g., such as molecules, macromolecules, and / or cells. The invention further provides methods for using such systems and components thereof. In one preferred aspect, the systems are used for spatially confined electroporation of cells and cell structures. The invention facilitates high throughput screening of agents (e.g., such as drugs) that act on intracellular targets.
Owner:CELLECTRICON
Self-Assembling Cell Aggregates and Methods of Making Engineered Tissue Using the Same
Owner:MUSC FOUND FOR RES DEV +1
Droplet-based cell culture and cell assays using digital microfluidics
ActiveUS20090203063A1Bioreactor/fermenter combinationsBiological substance pretreatmentsAssay3D cell culture
We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is sutable for assaying and culturing both cells in suspension and cells grown on surface (adherent cells). This method is advantageous for cell culture and assays due to the automated manipulation of multiple reagents in addition to reduced reagent use and analysis time. No adverse effects of actuation by DMF were observed in assays for cell viability, proliferation, and biochemistry. These results suggest that DMF has great potential as a simple yet versatile analytical tool for implementing cell-based assays and cell culture on the microscale.
Owner:THE GOVERNINIG COUNCIL OF THE UNIV OF TORANTO
Systems, devices, and methods for biomass production
InactiveUS20090047722A1Increased biomass productionDecreasing biomass production costBioreactor/fermenter combinationsBiological substance pretreatmentsCellular componentCisterna
Systems, devices, and methods for releasing one or more cell components from a photosynthetic organism. A bioreactor system is operable for growing photosynthetic organisms. Some of the methods include contacting the photosynthetic organism with an energy-activatable sensitizer, and activating the energy-activatable sensitizer, thereby releasing a cellular component from at least one of, for example, a membrane structure, tubule, vesicle, cisterna, organelle, cell compartment, plastid, or mitochondrion, associated with the photosynthetic organisms.
Owner:BIONAVITAS
Device for extracting nucleic acid from a sample
InactiveUS20080057572A1Efficient processingAccurate detectionBioreactor/fermenter combinationsHeating or cooling apparatusChemical reactionAnalyte
The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and / or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
Owner:CEPHEID INC
Automated devices, systems, and methods for the fabrication of tissue
InactiveUS20150037445A1Increase the number ofQuality improvementLiquid surface applicatorsConfectioneryBiomedical engineeringAutomation
Described herein are improvements to bioprinting technology that facilitate automation of tissue and organ fabrication processes.
Owner:ORGANOVO
Liquid processing method making use of pipette device and apparatus for same
InactiveUS20020123156A1Improve accuracyBioreactor/fermenter combinationsHeating or cooling apparatusPipetteEngineering
Technological preposition of the present invention is a liquid processing method making use of a pipette device which sucks a liquid containing a target high molecular substance from inside of a vessel through a chip detachably set on a sucking port or a discharging port of a liquid sucking / discharging line and transfers this liquid or target high molecular substance to the next target processing position for the purpose to execute such works as quantifying, separating, taking out, pipetting, cleaning, condensing, and diluting a liquid or a target high molecular substance contained in a liquid and also such works as extracting, recovering, and isolating the target high molecular substance by means of sucking and discharging a liquid with a pipette device and controls by a magnetic body over magnetic particles and / or a filter combined according to the necessity, and the chip can isolate the target high molecular substance by having the substance attracted onto magnetic particles or with a filter set on each chip.
Owner:PRECISION SYST SCI
Method for separating analyte from a sample
InactiveUS20050194316A1Simple designImprove efficiencyBioreactor/fermenter combinationsBiological substance pretreatmentsAnalyteElution
An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Owner:CEPHEID INC
Fluidic devices and systems for sample preparation or autonomous analysis
ActiveUS20130309679A1Bioreactor/fermenter combinationsHeating or cooling apparatusBiospecimenAnalytical chemistry
The present invention relates to fluidic devices for preparing, processing, storing, preserving, and / or analyzing samples. In particular, the devices and related systems and methods allow for preparing and / or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and / or automated analysis.
Owner:TALIS BIOMEDICAL CORP +1
Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
ActiveUS8216832B2Contamination riskBioreactor/fermenter combinationsBiological substance pretreatmentsAssayCollection system
Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.
Owner:PERKINELMER HEALTH SCIENCES INC
Devices, systems, and methods for the fabrication of tissue
ActiveUS20120116568A1Increase the number ofQuality improvementManufacturing platforms/substratesLiquid surface applicatorsComputer moduleEngineering
Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
Owner:ORGANOVO
Method and system for the production of cells and cell products and applications thereof
ActiveUS20090269841A1Minimization requirementsAvoid possibilityBioreactor/fermenter combinationsBiological substance pretreatmentsCell culture mediaComputer module
Owner:BIOVEST INT
Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
ActiveUS20100274155A1Contamination riskBioreactor/fermenter combinationsBiological substance pretreatmentsAssayCollection system
Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.
Owner:PERKINELMER HEALTH SCIENCES INC
Method and apparatus for co2 sequestration
InactiveUS20080274494A1Bioreactor/fermenter combinationsBiological substance pretreatmentsAlgaeBiological materials
A method and apparatus for growing algae for sequestering carbon dioxide and then harvesting the algae includes a container for a suspension of algae in a liquid and a bioreactor having a translucent channel in fluid communication with the container to absorb CO2 and grow the algae. A monitor determines the growth of the algae in the channel. A separator separates the grown algae from the suspension and an extractor extracts biomaterials from the grown algae.
Owner:KERTZ MALCOLM GLEN
Patch clamp apparatus and technique having high throughput and low fluid volume requirements
InactiveUS6063260ALow sample volume requirementLower the volumeBioreactor/fermenter combinationsBiological substance pretreatmentsAutosamplerIon transfer
PCT No. PCT / EP95 / 02204 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Jun. 7, 1995 PCT Pub. No. WO96 / 13721 PCT Pub. Date May 9, 1996Apparatus for carrying out patch clamp technique utilized in studying the effect of certain materials on ion transfer channels in biological tissue, and more particularly patch clamp apparatus utilizing an autosampler, such as those utilized with HPLC apparatus, to provide high throughput, is disclosed. The invention additionally includes novel microperfusion chamber assemblies capable of utilizing only small amounts of material to be tested and only small amounts of liquid carrier, thereby enabling many tests to be completed in a short period of time. The invention more broadly relates to a novel electrophysiology drug handling and application set up for screening of chemical substances while providing high throughput and requiring only low volume of solutions and samples to be tested. The invention also comprises several novel procedures for utilizing the apparatus of the invention.
Owner:SOPHION BIOSCI
Manufacturing within a single-use container
ActiveUS20160068793A1Function increaseProgramme-controlled manipulatorBioreactor/fermenter combinationsNumerical controlThree degrees of freedom
A manufacturing assembly has at least a sterilizable chamber containing at least one of a three-dimensional printing device (additive manufacturing), a Computer Numerical Controlled (CNC) finishing head (subtractive manufacturing), a vacuum-forming unit, an injection-molding unit, a laser-cutting unit, a ultrasonic-welding unit, a robotic arman analysis device, a sampling device or a combination thereof. A plurality of individual sterilizable chambers may be aseptically connected into a network of sterilizable chambers that provides additional functionality for the manufacturing assembly. A sterilizable printer assembly may include at least one printing head, a printing platform, and a driving mechanism adapted to perform a movement of the at least one printing head relative to the printing platform along three degrees of freedom; a printer housing enclosing the printer assembly in a sterile manner, at least one aseptic connector fluidly connected to a corresponding one of the at least one printing head.
Owner:SARTORIUS STEDIM BIOTECH GMBH
Mesoscale polynucleotide amplification devices
InactiveUS7892819B2Improve heat transfer performanceEfficient thermal cyclingBioreactor/fermenter combinationsSequential/parallel process reactionsHigh surfacePolynucleotide
Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction, chamber, having at least one cross-sectional dimension of about 0.1 to 1000 μm. The device also includes at least one port in fluid communication with the reaction chamber, for introducing a sample to the chamber, for venting the chamber when necessary, and, optionally, for removing products or waste material from the device. The reaction chamber may be provided with reagents required for amplification of a preselected polynucleotide. The device also may include means for thermally regulating the contents of the reaction chamber, to amplify a preselected polynucleotide. Preferably, the reaction chamber is fabricated with a high surface to volume ratio, to facilitate thermal regulation.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Automated method and apparatus for embryonic stem cell culture
ActiveUS20090029462A1Bioreactor/fermenter combinationsBiological substance pretreatmentsBiotechnologyCell cluster
The invention concerns methods for automated culture of embryonic stem cells (ESCs) such as human ESCs. In some aspects, methods of the invention employ optimized culture media and limited proteolytic treatment of cells to separate cell clusters for expansion. Automated systems for passage and expansion of ESCs are also provided.
Owner:FUJIFILM CELLULAR DYNAMICS INC
Perfused three-dimensional cell/tissue disease models
ActiveUS8318479B2Easy to primeBioreactor/fermenter combinationsBiological substance pretreatmentsLymphatic SpreadPathology diagnosis
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
Owner:MASSACHUSETTS INST OF TECH +1
Apparatus and methods for production of biodiesel
InactiveUS20080220515A1Improve efficiencyImprove cost effectivenessBioreactor/fermenter combinationsBiological substance pretreatmentsBiodieselPhotobioreactor
A photobioreactor includes a cultivation zone configured to contain a liquid culture medium and facilitate growth of a microalgae biomass, a plurality of parallel edge-lit light transmitting devices mounted within the cultivation zone, and a collection zone oriented in relation to the cultivation zone such that at least a portion of the liquid culture medium and microalgae from the cultivation zone may be periodically harvested. Methods for illuminating algae, for dissolving materials into an algae medium, for extracting oil from algae, and for producing biodiesel from algal oil are also provided.
Owner:MIP
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