3895 results about "Sample collection" patented technology

An apparatus and method for sealing a fluid sample collection device, comprising: loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates at an internal capillary stop; and slidably moving a sealing element over at least a portion of said substantially planar surface in a way that displaces any excess fluid sample away from the orifice, seals the fluid sample within said holding chamber, and inhibits the fluid sample from prematurely breaking through the internal capillary stop.

Abstract of Disclosure Devices, systems and methods are provided for piercing the skin, accessing and collecting physiological sample therein, and measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The subject devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. At least one fluid pathway resides within a portion of the biosensor and within the skin-piercing element. The skin-piercing element has a space-defining configuration therein which acts as a sample fluid pooling area upon penetration into the skin. Systems are provided which include one or more test strip devices and a meter for making analyte concentration measurements. Methods for using the devices and systems are also provided.

Analyte monitoring devices and methods therefore are provided. The devices integrate various functions of analyte monitoring, e.g., sample acquisition and testing.

An imaging endoscope comprising a shaft having a proximal end adapted to be secured to a handle, and a distal end having a biopsy forceps disposed therein. The biopsy forceps includes one or more end-effector elements that are actuated with a control cable that may be connected to the handle. The endoscope shaft includes a biopsy sample lumen that is configured to receive a biopsy sample obtained from the forceps assembly. A sample collection apparatus is attached to the handle to capture multiple biopsy samples. In some embodiments, the endoscope is a single-use endoscope.

Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

A collection agent monitors a mobile network for data samples containing executable code. The collection agent accepts executables and forwards them to a sample collection center for further analysis, reporting, or in some instances initiating one or more mitigating actions. Depending on the network protocol being monitored, the collection agent responds to connection attempts from nearby mobile devices.

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and / or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and / or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and / or particle-based analyses and may be used in conjunction with membrane- and / or particle-based analysis cartridges. Analytes, including proteins and cells and / or microbes may be detected using the membrane and / or particle based analysis system.

Analyte monitoring devices and methods therefore are provided. The devices integrate various functions of analyte monitoring, e.g., sample acquisition and testing.

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

Systems and methods are provided for collecting, preparing, and / or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and / or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and / or preventing a disease in the subject.

A lancing device and method for self-collecting a sample of body fluid by penetrating a body tissue at a sampling site. The invention includes a housing geometry configured for ease of use at different sampling sites on the body, even by persons having reduced dexterity and / or poor vision. Depth of penetration is selectively controlled by adjusting the stroke range of a spring-driven lancet carrier. A pressure applicator is included for stimulating flow of the body fluid. A transparent portion permits observation of the sampling site.

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and / or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and / or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and / or particle-based analyses and may be used in conjunction with membrane- and / or particle-based analysis cartridges. Analytes, including proteins and cells and / or microbes may be detected using the membrane and / or particle based analysis system.

The invention relates to a microsampler puncturing system for collecting a body fluid from a body part, comprising a sample collection unit having a piercing element, and a puncturing instrument having a drive, by which a sample collection unit is movable on a movement path for piercing the piercing element into the skin of the body part and withdraw it again by means of a piercing and retraction movement, a setting device for setting the puncturing depth of the piercing wound to be generated, and a control device for controlling the piercing and retraction movement having the following sequentially executed movement phases: a forward phase (V), in which the piercing element is pierced up to a defined puncturing depth (dm), a retraction phase (R1), in which the piercing element is partially retracted by a retraction distance (Δd) and is decelerated toward the end of the retraction phase (R1), so that it remains projecting into the skin at a defined residual puncturing depth (dr), and a collecting phase (S), in which the piercing element projects into the skin and a body fluid sample is absorbed by the sample collection unit. The setting device is adapted for the defined puncturing depth is settable independently of the chronological mean <dr> of the defined residual puncturing depth (dr), with reference to the collecting phase.

A surgical cutting device comprises a cannula attached to an actuation mechanism that moves the cannula from a cocked position to a cutting position, a stylet including a distal portion having a sharp distal end, a sample collection region, a vacuum port, and a lumen extending from the vacuum port to the sample collection region such that the sample collection region is in fluid communication with the first vacuum port. When the cannula is in the cocked position, the sample collection region of the stylet is disposed distal of the cannula. The device also includes a fixed volume vacuum source. When cannula is in the cocked position, the vacuum port is not in fluid communication with the fixed volume vacuum source, and when said cannula is in the cutting position, the vacuum port is in fluid communication with the fixed volume vacuum source.

A lancing device and method for self-collecting a sample of body fluid by penetrating a body tissue at a sampling site. The invention includes a housing geometry configured for ease of use at different sampling sites on the body, even by persons having reduced dexterity and / or poor vision. Depth of penetration is selectively controlled by adjusting the stroke range of a spring-driven lancet carrier. A pressure applicator is included for stimulating flow of the body fluid. A transparent portion permits observation of the sampling site.

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and / or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and / or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and / or particle-based analyses and may be used in conjunction with membrane- and / or particle-based analysis cartridges. Analytes, including proteins and cells and / or microbes may be detected using the membrane and / or particle based analysis system.

Methods for processing a contact surface, for example to provide a gas barrier or lubricity or to modify the wetting properties on a medical device, are disclosed. First and second PECVD or other contact surface processing stations or devices and a contact surface holder comprising a contact surface port are provided. An opening of the contact surface can be seated on the contact surface port. The interior contact surface of the seated contact surface can be processed via the contact surface port by the first and second processing stations or devices. contact surface barrier, lubricity and hydrophobic coatings and coated contact surfaces, for example syringes and medical sample collection tubes are disclosed. A contact surface processing system and contact surface inspection apparatus and methods are also disclosed.

Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with a solid phase sample collection medium, alternatively facilitated by administering oxytocin to the subject. The breast pump device stimulates expression of mammary fluid and provides for collection of diagnostic samples to evaluate breast disease, including cancer. The biological sample may include whole cells or cellular components, purified or bulk proteins, glycoproteins, peptides, nucleotides or other desired constituents comprising a breast disease marker. Methods, kits and adapter devices relating to the breast pump device are also provided. Yet additional methods, devices, accessories, and materials are provided for laboratory handling and processing of breast fluid samples and for related diagnostic methods.

A measurement system is provided which comprises an analysis device with at least one of a measurement function and a sample collection function, and also at least one magazine configured to receive at least one consumer element therein. The magazine comprises a magazine housing having a pair of openings. The magazine is designed as an exchangeable magazine that can be selectively operatively connected to the analysis device. The analysis device further comprises a closure mechanism having at least one sealing element which is designed to convey at least one consumer element from one of the openings. The sealing element is further configured to sealingly close the openings of the magazine when the sealing element is disposed therein.

Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

Diagnostic products having multiple test strips within a unitary diagnostic test device, or test icon, are described herein. In the preferred embodiments of the diagnostic test device of this invention, a fluid sample distribution system is provided wherein a sample collection and distribution port is provided in the housing for receipt of a biologic fluid sample and the channeling of such sample onto a sample receiving web. The sample receiving web, which is located within the test device, is in fluid communication with an array of test strips, and is configured to deliver an aliquot of biologic fluid sample to the test site of each such test strip at essentially the same rate. In the preferred embodiments of this invention, the sample receiving web comprises at least one base segment and at least one branched segment. Each of the base and branched segments can be formed or cut from a common sheet of material or from separate sheet material and thereafter placed in contiguous relationship one another. The relative placement of the sample receiving web within the test device is coincident with a portion of each test strip and designed to effect the balanced distribution and delivery of an aliquot of the biologic fluid sample to the test site of each of the test strips within the test device.

The invention relates to a method for creating a puncture wound for obtaining a sample of a body fluid from a body part in which a skin opening is created at a puncture site in the epidermis in a skin-opening step. Then, in a sample collection step a sample collection puncture is executed by using a puncture element with which the skin opening is deepened with the puncture element, thereby creating a puncture wound for obtaining the sample. The invention also relates to a handheld apparatus for implementing this method.

An endcap for a lancing device having an opening formed therein for passing a lancet tip, and a contact face surrounding the opening, with at least one spaced rib, dimple or projection thereon. In various embodiments, multiple ribs are spaced around the opening in a helical, circular or radial array. The contact face can be planar, concave or convex. The endcap increases the surface area in contact with the skin around the sampling site to enhance blood flow and prevent premature wound closure during sample collection.

A device for sampling of a mixture of ultrafine particles within a moving gas stream includes a suction generator, at least one sample collection element, and a conduit structure coupling the sample collection element with the suction generator. In some embodiments, the suction generator is configurable to separate by suction a portion of a gas stream containing a plurality of ultrafine particles, and to entrain with a motive fluid forming an output mixture. In some embodiments, a conduit is configured to accept a gas stream containing ultrafine particles and to channel it to the collection element.

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and / or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and / or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and / or particle-based analyses and may be used in conjunction with membrane- and / or particle-based analysis cartridges. Analytes, including proteins and cells and / or microbes may be detected using the membrane and / or particle based analysis system.

The present invention provides a decision management system to define, validate and extract data for predictive models. A system of sensors is deployed in a sample collection environment, where such sensors are used to collect data from a biological or chemical sample, with additional sensors for ambient data whose output as a form of metadata can characterize performance conditions including background ambient conditions. A format or sequence of processes is the basis for a math model to establish a logical weight to data for predictive modeling and event reporting. The present invention provides a computer or other sensor interface system with a primary sensor or sensors, network connection, and supplementary sensors to measure the conditions in which the primary data is captured. A software process allows for user inputs of data in order to establish the methods and rules for normal function.

A tip portion or endcap for a lancing device having a non-circular opening to provide tension and pressure upon the patient's skin before and / or during lancing of the skin for sample collection. In example embodiments, the endcap is shaped to prevent the lancet body from sticking within the hole or passing through the hole. The endcap may also be shaped to allow it to be used at various lancing sites on the body without changing the endcap.

The present invention relates to a sterile sample collection device for fluids and a method of using the same. It is comprised of a transfer device having a body with a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to tube which is then connected to a collection bag. The plunger has corresponding first and second ends. The first end of the plunger when in the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components.

Systems and methods are provided for collecting, preparing, and / or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and / or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and / or preventing a disease in the subject.