93 results about "Fluid specimen" patented technology

The utility model provides a microfluid sample detection device which comprises a fluid inlet, a microfluid channel, a fluid outlet, a reaction area, a liquid collecting area, a pump body and a valve body, the valve body comprises a substrate, a double-sided colloid and a flexible diaphragm, a cavity is formed between the upper surface of the plastic substrate and the lower surface of the flexible diaphragm, the cavity is opened when the flexible diaphragm is loosened, and the cavity is closed when the flexible diaphragm is tensioned; the valve body comprises a first valve body, a second valve body, a third valve body and a fourth valve body, the second valve body and the third valve body are arranged between the pump body and the microfluid channel and located on the downstream portion of the first valve body, and the working states of the third valve body and the fourth valve body are opposite. Moreover, the parallel scheme further comprises a conductive system composed of electrodes, the conductive system at least comprises two electrodes, and the electrode sensing ends are located at the two ends of the reaction area respectively. The microfluidic sample detection device is loaded in a detection device to form a microfluidic sample detection system.

The utility model provides a microfluid sample detection device and a microfluid sample detection system. The microfluid sample detection device comprises a fluid inlet, a microfluid channel, a fluid outlet, a reaction area, a liquid collecting area, a pump body, a valve body and a lock body, the valve body comprises a substrate, a double-sided colloid and a flexible diaphragm, a cavity is formed between the upper surface of the plastic substrate and the lower surface of the flexible diaphragm, the cavity is opened when the flexible diaphragm is loosened, and the cavity is closed when the flexible diaphragm is tensioned; the valve body comprises a first valve body and a second valve body, the second valve body is arranged on the downstream of the first valve body, and the working states of the first valve body and the second valve body are opposite; the lock body is arranged on the downstream of the second valve body. Moreover, the parallel scheme further comprises a conductive system composed of electrodes, the conductive system at least comprises two electrodes, and the electrode sensing ends are located at the two ends of the reaction area respectively. The microfluidic sample detection device is loaded in a detection device to form a microfluidic sample detection system.

A method includes determining whether a variation in probe radiation intensity meets a stability criterion; directing the probe radiation through a probe, when the probe is disposed at a first position, defining a first path length L1 of the probe radiation through the fluid sample; measuring a transmitted intensity I1 of the probe radiation after passing through the fluid sample when the probe is disposed at the first position; directing the probe radiation through the probe when the probe is disposed at a second position, defining a second path length L2 of the probe radiation through the fluid sample; measuring a transmitted intensity I2 of the probe radiation after passing through the fluid sample when the probe is disposed at the second position; and determining a concentration C of a material in the fluid sample based upon L1, I1, L2, and I2, when the stability criterion is met.

A fluid flushing system includes a sampling port comprising a sampling conduit configured to dispense a sample of a fluid in the fluid routing assembly; a valve configurable in an open valve configuration, wherein the fluid is permitted to flow through the fluid flushing system, and a closed valve configuration, wherein the fluid is prohibited from flowing through the fluid flushing system; and a backflow preventer disposed between the sampling port and the valve, the backflow preventer configured to allow the fluid to flow in a first direction through the fluid flushing system towards the valve and to prevent the fluid from flowing in an opposite second direction through the fluid flushing system towards the sampling port.

A system includes a pipeline for flowing a fluid therein and a multiphase sampler fluidly coupled to the pipeline. The multiphase sampler includes an inlet to receive a fluid sample of the fluid from the pipeline, a Tesla valve(s) coupled between the pipeline and the inlet of the multiphase sampler to direct a flow of the fluid sample into a sensing section, and an outlet to return the fluid sample back into the pipeline. The sensing section includes at least one sensor to determine a water-cut of the fluid sample. A method includes flowing a fluid through a pipeline, streaming off a fluid sample from the fluid into an inlet of a multiphase sampler, determining a water-cut of the fluid sample in a sensing section of the multiphase sampler, and directing the fluid sample back into the pipeline.

The application belongs to the technical field of biology and specifically relates to a method for analyzing glycans on single extracellular vesicles in a fluid sample. The method uses magnetic nanoparticles to capture and manipulate EVs, based on the specific affinity of lectins for specific glycan structures, uses polydisperse microdroplets to separate the captured EVs, realizes local signal amplification in the droplets through enzymatic reaction, adopts fluorescence microscopy to collect images of the droplets, and thus realizes identification and analysis of the glycan components on single EVs. The preparation process of the microdroplets formed by the oscillating emulsification method of the application makes the entire detection process more simple and fast, does not require any microfluidic chip and special device, and can be completed in a centrifugal tube, and all the microdroplets are generated in parallel and quickly, and the amount of microdroplets can be flexibly expanded. Moreover, compared with the traditional ELISA, the method has high sensitivity, low detection limit and small sample consumption.

The invention belongs to the technical field of sampling, and particularly relates to a ball valve convenient for online maintenance, which comprises a sampling ball valve, the sampling ball valve comprises a connecting shell and a sampling shell mounted below the connecting shell, a sampling bottle is movably mounted below the sampling shell, and an upper sealing ring and a lower sealing ring are fixedly mounted at the inner top of a sampling cavity. A valve ball is rotatably installed between the upper sealing ring and the lower sealing ring, a water inlet and outlet pipe is fixedly installed on the two sides of the sampling shell, the valve ball comprises a fluid passing body and an abutting cover, and through rotation of the valve ball, fluid in the fluid passing body can enter a sampling bottle installed on the sampling shell through a sampling cavity and the valve ball to be subjected to subsequent detection work; purified water enters from one group of water inlet and outlet pipes and then flows out from the other group of water inlet and outlet pipes through the valve ball and the interior of the sampling cavity where the valve ball is located, so that the originally retained fluid is reduced, the online cleaning and maintenance function is deepened, and the quality of a fluid sample sampled next time is ensured.

The present application provides a kind of microfluidic sample detection device and microfluidic sample detection system, and detection equipment and microfluidic detection device electrode electrically / signal connection forms microfluidic sample detection system.Microfluidic sample detection device, including fluid inlet, microfluidic channel and fluid outlet, and reaction zone, liquid collection area, first pump body, first valve body, second valve body, third valve body and fourth valve body, the working state of third valve body and fourth valve body is opposite.First pump body, when being communicated with microfluidic channel, provides driving force for the flow of microfluidic sample;Second valve body, it is located between first pump body and microfluidic channel, and located downstream of first valve body;Third valve body, it is located between first pump body and microfluidic channel, and located downstream of second valve body.First pump body can be communicated with microfluidic channel by second valve body or / and third valve body.

A container assembly for collecting a fluid specimen including a collection container having a first end, a second end, and a sidewall extending therebetween and defining a chamber for receiving the fluid specimen. The container assembly may include a container lid couplable to the collection container to at least partially close the first end thereof. The container lid may include a sealing interface configured to at least partially contact the collection container when the container lid is coupled to the collection container. The sealing interface may include a textured sealing surface region configured to allow air into or out of the container assembly when the container lid is coupled to the collection container, while maintaining a substantially fluid-tight seal between the container lid and the collection container.

A method for delivering a fluid sample through a channel of a diagnostic consumable is disclosed. The method includes receiving the diagnostic consumable in a reader comprising a delivery system, operatively connecting the delivery system to the channel, and applying pressure pulses to the channel at a predetermined frequency. A reader for reading a diagnostic consumable is also disclosed.

In an embodiment, a fluid concentration measurement system is disclosed. The measurement system comprises a sensor device comprising a sampling and measurement unit that is configured for insertion into a fluid stream. The sampling and measurement unit is configured to obtain a fluid sample from the fluid stream and to mix a reagent with the fluid sample to form a mixed sample. The sensor device further comprises a light source that is configured to illuminate the mixed sample and an optical sensor. The optical sensor is configured to receive light from the mixed sample based at least in part on the illumination of the mixed sample and generate sensor data based on the received light. The measurement system further comprises at least one processor that is configured to obtain the sensor data and determine a concentration of a target analyte in the fluid stream based on the sensor data.

A hematology analyzer for analyzing a fluid sample and comprising a frame body defining a first axis (X-X′) and a second axis (Y-Y′), a cartridge unit having a first compartment containing the fluid sample and a second compartment containing a cleaning fluid, a fluid analysis module comprising a first probe and a second probe, a first transmission unit configured to hold and move the cartridge unit along the first axis (X-X′) to align the first compartment and the second compartment with the first probe and the second probe, respectively, and a second transmission unit configured to move the fluid analysis module along the second axis (Y-Y′) such that the first probe and the second probe pierce the first compartment and the second compartment, respectively.

An apparatus and method for image analysis of a fluid sample on a test card are disclosed. An example apparatus for analyzing a fluid sample includes a camera imaging device configured to record a plurality of images of the fluid sample while located within a target zone of a fluid microchannel of a test card. The example apparatus also includes a controller configured to perform a cytometry analysis on the fluid sample to determine whether the fluid sample tests positive or negative for a bacteria or virus.

A bioelectrical sensor for detecting one or more pathogens in a fluid sample is provided. The bioelectrical sensor receives a fluid sample comprising one or more pathogens, and detects the one or more pathogens using a series of chemical reactions. The series of chemical reactions include a detection step in which a detector organism detects a pathogen upon coming into contact with and / or to within a certain proximity of the pathogen, and a reporting step in which a reporter organism responds to the detection by generating an electrical signal comprising information about the detected pathogen. The electrical signal may then be transmitted to a computing device, which may identify the pathogen by mapping the generated electrical signal to a known pathogen.

The petroleum distribution sampler comprises a driving device, a support is fixedly connected to the position, close to the bottom end, of the outer side of the driving device, a telescopic rotating rod is fixedly connected to the bottom end of the driving device, a collecting mechanism is movably connected to the bottom end of the telescopic rotating rod, a circular opening is formed in the center of the middle of the support, and a sleeve penetrates through the opening; a fixing ring frame is fixedly connected to the outer side of the top end of the sleeve, an air supply device is arranged on the left side of the fixing ring frame and fixedly connected with the support, the collecting mechanism comprises a collecting drill pipe, and the inner side of the top end of the collecting drill pipe is movably connected with the bottom end of a telescopic rotating rod. The invention relates to the technical field of oil exploitation, and has the characteristics that the practicability is high, fluid and non-fluid samples can be classified, and the influence of cold climate is relatively small.

Methods of using particle size amplification to facilitate size-based particle separation and concentration. At least one of the methods includes introducing a plurality of binding moieties into a fluid sample; allowing at least one of the binding moieties to bind two or more biological particles to form a particle cluster, in which the particle cluster includes a first type of biological particle bound to a second different type of biological particle; and flowing the fluid sample including the particle cluster into a particle sorting region of a microfluidic device.

Systems, devices, and methods for determining health characteristics are disclosed herein. In some embodiments, a method includes receiving a fluid sample from a user and transferring at least some of the biological cells of the fluid sample through a microchannel including (i) an upstream viscosity-elimination section sized to compress the biological cells and (ii) a downstream measurement section sized to keep the biological cells compressed to measure one or more elastic characteristics of the biological cells. The method can continue by measuring parameters of the biological cells at first and second detection regions of the downstream measurement section, and determining, based on the measured parameters of the biological cells at at least one of the first or second detection region, a health characteristic of the user.

The invention relates to a gas chromatograph apparatus, system and method with a modular architecture. An apparatus includes a first circuit configured to: provide a control signal for an inlet valve of a manifold plate to a second circuit of the manifold plate; receiving an attribute of the fluid sample from a third circuit of the analysis module; and determining a physical composition of the fluid sample based on the measured attribute of the fluid sample. The manifold plate includes a second circuit and an inlet valve and an inlet channel, the second circuit configured to control the inlet valve based on the control signal to direct the fluid sample from the inlet valve through the inlet channel to the analysis module. The analysis module is secured to the manifold plate and includes a gas chromatograph oven and a third circuit configured to measure a property of a fluid sample in the gas chromatograph oven using one or more sensors.

An apparatus for sampling a fluid from a flowline comprises a housing and a pressure control barrier moveably mounted in the housing. The apparatus comprises a sample chamber within the housing on a first side of the pressure control barrier and being fluidly connectable to the flowline for receiving a fluid sample from the flowline, and a pressure control chamber within the housing on an opposite second side of the pressure control barrier, wherein pressure applied within the pressure control chamber controls pressure of the fluid sample within the sample chamber. The apparatus comprises a guided wave radar device for determining a property of the fluid sample within the sample chamber.

The present invention relates to porous membrane sensor elements for detecting analytes in complex fluid samples. The porous membrane sensor element includes: a porous membrane sensor housing penetrated by a flow channel defining an axial direction; a porous membrane having a front side defining a sensor surface for contacting the fluid sample, the porous membrane comprising pores extending from respective openings of the sensor surface into the porous membrane, where the pores are configured for spatially diffusing fluid communication with the sample relative to the analyte; and an optical subassembly comprising a light guide core, the light guide core comprising an input branch, an output branch, and a coupling interface arranged to contact a back side of the porous membrane opposite the front side and facing away from the sample space; wherein the input and output branches point to the coupling interface. The input branch and the output branch are arranged in a common light guide plane arranged perpendicular to the sensor surface. According to another aspect, a sensor assembly includes a porous membrane sensor element integrated within a sample chamber thereof.

A system for detecting a target bacteria is disclosed. The system comprises a flow cytometer. The flow cytometer is configured to receive a fluid sample, wherein the fluid sample comprises at least a target bacteria and at least a contaminant bacteria. The flow cytometer is also configured to generate a first enumeration of a total bacteria in the fluid sample during a pre-incubation phase. The fluid sample is then incubated during an incubation phase. The flow cytometer then generates a second enumeration of the total bacteria in the fluid sample during a post-incubation phase. A computing device then determines a growth ratio of the total bacteria as a function of the first enumeration and the second enumeration. Finally, the computing device identifies the presence of the at least a target bacteria as a function of the growth ratio.

A method for capturing images of a liquid immunoassay to determine a concentration of a target analyte in a fluid sample, comprising: collecting, with a camera, a plurality of images of a fluid stream over an assay, the assay comprising a matrix having a surface functionalized with Ab, and the fluid stream comprising a plurality of particles, in one embodiment, a method for determining a concentration of a target analyte in a fluid flow includes providing a functionalized surface with a plurality of particles that become bound to the functionalized surface in the presence of the target analyte, combining images of the fluid flow to obtain a processed image, identifying one or more particles bound to a matrix in the processed image, and determining a concentration of the target analyte in the fluid flow based on the number of particles bound to the matrix. A system is also provided that includes a memory having instructions and a processor that executes the instructions and causes the system to perform the above method.

The present disclosure relates to a drilling spill determination method and computer program, the method comprising: determining a current gas content and an actual annulus flow rate of a fluid within a drilling annulus based on a fluid sample at a drilling casing shoe; wherein the annular space is located between the inner wall of a casing pipe of a drilled well and the outer wall of a drill rod; under the condition that the current gas containing rate is smaller than a preset gas containing rate threshold value, the current working condition is determined according to preset parameters of well drilling; determining an annulus flow velocity determination model corresponding to the current working condition according to a preset corresponding relation between the annulus flow velocity and the working condition, and determining a theoretical annulus flow velocity under the current working condition according to the annulus flow velocity determination model; and judging whether overflow leakage occurs or not according to the actual annular flow velocity and the theoretical annular flow velocity. According to the method, the accuracy of overflow leakage judgment is improved, the false alarm rate of overflow leakage judgment is reduced, the effectiveness of the method for monitoring the gas cut at the casing shoe is guaranteed, and the practicability of monitoring the gas cut at the casing shoe is improved.

A device for measuring fluid parameters may be modular or integrally formed. The device is positioned on a machine that includes one or more fluids to be monitored, and the device includes a (1) controller, (2) spacer that connects to a power source and that may include one or more connectors to connect to remote sensors, and (3) an optional manifold through which the fluid may pass. The manifold could include fluid sensors and / or be connectable to a sample bottle for the purpose of taking fluid samples.

The present invention provides a device for collecting a fluid specimen. The device comprises a water-absorbing end part formed by bonding a first porous water-absorbing film and a second porous water-absorbing film. Preferably, the second porous water-absorbing film and the first porous water-absorbing film are sponge films.

A method of detecting presence or absence of a target pathogen / molecule within a fluid sample and related test devices are described. The test device includes a body, a first fluid passageway extending within the body, and a plurality of second fluid passageways extending within the body. The first fluid passageway has an inlet, a first chamber, and a first isolation valve that is operable to control fluid flow into the first chamber from the inlet. Each second fluid passageway is in fluid communication with the first chamber and includes a second chamber and a second isolation valve that is operable to control fluid flow into the second chamber from the first chamber. The first chamber receives an input sample via the inlet and each second chamber contains a detection reagent, such as a CRISPR / Cas reagent, that is configured to undergo a visually detectable change.

The present invention relates to a microfluidic distribution chip, comprising a sample addition hole, a sample inlet pipe, a distribution chamber, an exhaust pipe, a sample outlet pipe, an exhaust hole and a bypass pipe connected in sequence. The bypass pipe connects the sample inlet pipe and the sample outlet pipe, and is used to allow the fluid sample added through the sample addition hole to flow to the sample outlet pipe via the bypass pipe after filling the distribution chamber. The direction of the fluid can be controlled by limiting the cross-sectional area or depth of each pipe and cavity. The microfluidic distribution chip provided by the present invention has a simple structure, is easy to manufacture and easy to use. While realizing automatic sample distribution, it can ensure the purity of the sample, thereby completing multi-index parallel detection of the sample.

The present invention relates to an oral fluid sample collection method and device comprising: a shroud having a first face and a second face; an elastomeric nipple having an outer surface and defining a nipple interior, the elastomeric nipple extending from the first face of the shroud; and a reservoir component comprising a reservoir having a reservoir interior extending from the second face of the shroud. The elements are interconnected by a plurality of fluid conduit / valve combinations, including a first combination allowing flow from the nipple interior to an atmospheric vent port disposed on an outer surface of the oral fluid collection device; a second combination allowing flow from the reservoir interior to the nipple interior; and a third combination allowing flow from a collection port disposed on the outer surface of the nipple to an exit port in the reservoir interior.