21 results about "Pleural fluid" patented technology

The utility model discloses a water seal bottle with no influence on metering statistics after dumping, which comprises a bottle I, an inner cavity of the bottle I is a hydrops cavity, a drainage tube is arranged on the bottle I, the hydrops cavity comprises a small-volume cavity, a medium-volume cavity and a large-volume cavity, and hydrothorax flows into the hydrops cavity through the drainage tube and sequentially fills the small-volume cavity, the medium-volume cavity and the large-volume cavity. When liquid flows into the small volume cavity, the valve plate A generates elastic deformation, and the opening of the small volume cavity is opened; and when the liquid flows out of the small cavity, the valve plate A recovers and the opening of the small cavity is closed. When liquid flows into the middle accumulation cavity, the valve plate B is elastically deformed, and the opening of the middle accumulation cavity is opened; and when liquid flows out of the middle accumulation cavity, the valve plate B restores and the opening of the middle accumulation cavity is closed. The opening of the small accumulation cavity is sealed through the valve plate A, and the opening of the middle accumulation cavity is sealed through the valve plate B, so that liquid in the liquid accumulation cavity is prevented from flowing disorderly among the small accumulation cavity, the middle accumulation cavity and the large accumulation cavity, and the purpose that metering statistics is not affected after the water-sealed bottle topples is achieved.

The application discloses a kind of carbon-nitrogen fluorescent quantum dot tumor cell detection kit and its use method, it is characterized in that, including A liquid and B liquid;Wherein, the A liquid is carbon-nitrogen fluorescent quantum dot solution, the B liquid is buffer solution;The carbon-nitrogen fluorescent quantum dot solution is composed of carbon-nitrogen fluorescent quantum dot and solvent.Its use process, at least includes the following steps: step S10, provides reagent kit A liquid, B liquid, patient pleural fluid, urine sample;Step S20, high-speed centrifugation, after B liquid resuspension, add A liquid dyeing;Step S30, high-speed centrifugation, B liquid resuspension;Step S40, spectrophotometer detects fluorescence intensity.The detection of tumor cells in pleural fluid and urine tissue fluid of the application has high specificity and high sensitivity, and simple operation, cost is small.Not only can improve the diagnosis level of doctor to clinical tumor patient, also can provide help for prognosis evaluation of tumor, drug screening, individualized treatment.

The utility model discloses a drainage bag capable of collecting pleural effusion and sediment respectively. The lower portion of a drainage bag body is in a hopper shape. The liquid outlet assembly is arranged at the bottom end of the drainage bag body and comprises a liquid outlet channel arranged at the bottom end of the drainage bag body; a manual valve is arranged on the liquid outlet channel and is used for controlling the liquid outlet channel to be opened or closed; the sediment collecting assembly comprises a cylindrical first box body, the top end of the first box body is provided with a liquid inlet, and the liquid inlet is provided with a protective cap; a filter screen is fixedly arranged in the first box body and is used for filtering precipitates; the pleural effusion collecting assembly is arranged below the sediment collecting assembly, and when the second box body is installed at the bottom end of the first box body, the pleural effusion collecting assembly is used for collecting pleural effusion. According to the drainage bag capable of respectively collecting pleural effusion and sediment, the whole operation process is simple, convenient and environment-friendly; the operation of cutting off the drainage bag in a traditional mode is avoided, and meanwhile the problem that pleural effusion leaks to pollute the environment when the drainage bag is cut off is avoided.

An indwelling pleural catheter system comprises an indwelling catheter device (2) comprising a catheter tube (7) with a fenestrated distal end (7A) configured to reside in the pleural cavity of a subject and a connection hub (10) fluidically coupled to a proximal end (7B) of the catheter tube, a skin anchoring member (3) to anchor the connection hub (10) to the skin of the subject, and optionally a detachable ambulatory suction module (4) configured for detachable attachment to the connection hub (10). The suction module (4) comprises a fluid inlet (19) configured for fluidic coupling to the catheter tube (7) through the connection hub (10) and a fluid outlet (20) configured for detachable fluidic coupling to a pleural fluid drainage system (5) to drain pleural fluid through the detachable ambulatory suction module. The detachable ambulatory suction module is configured to exert a negative pressure in the catheter tube upon detachment of the pleural fluid drainage system from the suction module. Treatment of pleural effusion using the system of the invention is described. An indwelling catheter system for draining fluid from the peritoneal cavity, and methods of treating ascites, is also described.

The application relates to a multi-modal medical image classification method based on tensor decomposition subspace fusion. We first construct a multi-modal pleural fluid cell dataset and label the cell categories. In view of the common problems existing in the existing multi-modal fusion, a fusion framework based on the subspace level is designed. Based on a general image classification network, for the cell pictures of two modes, two independent convolutional neural networks are used to extract high-dimensional features, and the extracted high-dimensional features are decomposed to obtain low-dimensional feature subspaces. In the subspace, a self-attention mechanism is used to fully utilize the correlation of each part in the subspace, so as to change the spatial structure of the original features. Finally, the feature subspace is reconstructed to obtain the fully fused features for classification. The application is suitable for multi-modal medical image fusion classification tasks, such as cell category detection, fundus image age-related macular degeneration category detection and skin cancer melanoma detection.

In an embodiment, the present invention relates to a technique in which small-sized cfDNA is detected, with ultrahigh sensitivity, from a liquid sample such as urine, cerebrospinal fluid, plasma, blood, pleural fluid, or body fluid, is concentrated and isolated, and then is analyzed for gene mutations without PCR. In particular, in a case where a positively charged nanostructure is used, capture and detection rates for cfDNA can be increased. A detection method according to an embodiment of the present invention does not require a PCR amplification reaction, which greatly shortens the time taken to obtain a result. In addition, since direct on-site analysis is possible without the need for specific equipment, it is expected that the present invention can be used as a point-of-care testing (POCT) capable of simultaneously searching multiple genes in a short period of time.

The invention discloses a disposable 700ml limited type puncture drainage bag special for pleural effusion, belongs to the field of clinical medical instruments, and is particularly suitable for drainage of tuberculous pleural effusion and cancerous pleural effusion in a tuberculosis high-incidence area and emergency treatment of war wounds. According to the drainage bag, a special thoracocentesis assembly, an integrated flow control drainage hose and a disposable 700ml pre-filled negative pressure suction bottle are integrated into a sterile integrated kit, the special thoracocentesis assembly comprises a puncture needle with a side hole and a graduated drainage catheter, the middle section of the drainage hose is provided with an integrated buckle clamp, 700ml graduation lines are calibrated by the suction bottle, negative pressure of-0.04 MPa to-0.06 MPa is pre-filled, and the disposable 700ml pre-filled negative pressure suction bottle is provided with a drainage tube. Seamless butt joint is achieved through a Luer taper. The disposable design completely eradicates mycobacterium tuberculosis cross infection, rapid butt joint adapts to battle wound first aid, multi-time flow control meets the cancerous hydrothorax treatment requirement, additional transfer is not needed, unpacking and instant use are achieved, operation is convenient, safety is high, cost is low, and the device is suitable for all levels of medical institutions, grassroots units, field first aid and other scenes and has wide application prospects. The kit is especially suitable for large-scale clinical application in tuberculosis high-incidence areas, and the popularization value is remarkable.

The utility model discloses an anti-leakage medical application for a drainage tube, which comprises an absorption dressing and a pressurization dressing, the absorption dressing comprises a lower absorption layer, the center of the lower absorption layer is provided with a lower tube hole, and the edge of the lower tube hole leading to the lower absorption layer is provided with a lower separation line; the pressurized dressing comprises an upper absorption layer, a silica gel plug and a waterproof layer which are sequentially attached from bottom to top. The shapes and sizes of the cross sections of the lower absorption layer, the upper absorption layer and the silica gel plug are the same and are smaller than the size of the waterproof layer. According to the drainage tube, the puncture opening of the drainage tube is pressurized, the puncture opening is blocked, ascites or pleural fluid possibly leaking out of the puncture opening is absorbed at the same time, the dry and sterile environment in the sterile dressing is guaranteed, the times of dressing replacement and the infection incidence rate are reduced, and the medical compliance of a patient is improved.

The utility model discloses a sticking type pleural effusion colorimetric card, and belongs to the technical field of medical instruments. A pasting type pleural effusion colorimetric card comprises a colorimetric card front face and a colorimetric card back face, the colorimetric card front face and the colorimetric card back face are formed by attaching two pieces of transparent soft plastic, and a first transparent area is arranged on one side where the colorimetric card front face and the colorimetric card back face are pasted together. And a second transparent area is arranged on the other side where the colourimetric card front surface and the colourimetric card back surface are bonded together. According to the sticking type pleural effusion colorimetric card disclosed by the utility model, through the built-in liquid bag and the colorimetric card, possible colors of pleural effusion under different causes can be simulated, and more real color display is ensured, so that medical staff can quickly and accurately identify the color change of the pleural effusion, more accurate preliminary diagnosis can be made, and the accuracy of diagnosis is improved. And a detailed diagnosis area is arranged below each liquid bag, so that medical staff can quickly acquire possible causes of diseases of corresponding colors, and the possibility of misjudgment is reduced.

The present application relates to the technical field of tumor immunotherapy, and particularly relates to HLA-A*11:01 restricted neoantigen peptides based on malignant pleural effusion tumor cells and application thereof. The present application obtains tumor neoantigen polypeptides by separating and screening from malignant pleural effusion of lung cancer patients, the amino acid sequence of the neoantigen polypeptides is shown in any one of SEQ ID NO. 1-9; the tumor neoantigen polypeptides have high affinity with HLA molecules, can stimulate tumor-specific T cells, and can be used as a target for tumor clinical treatment or diagnosis. The present application further provides a method for separating and screening tumor neoantigen polypeptides, which solves the problem that the neoantigen of non-surgical treatment patients cannot be obtained, and provides an effective method for development of tumor neoantigen polypeptides.

The invention provides a construction method of a pleural effusion-derived tumor cell line of a lung adenocarcinoma patient, and belongs to the technical field of cell construction. The method comprises the following steps: carrying out single cell level accurate separation and purification on pleural effusion of a lung adenocarcinoma patient, carrying out cell type identification and tumor cell pre-enrichment in combination with a single cell transcriptome sequencing technology before primary culture, and carrying out incubation, subculture and subsequent accurate enrichment. And a tumor cell line which is highly enriched and has stable genetic characteristics is successfully obtained. The tumor cell line constructed by the method disclosed by the invention can be passaged for multiple times, so that individualized tumor antigen information and unique gene expression profiles of patients are reserved to the greatest extent, and meanwhile, the challenges of serious hybrid cell pollution, low tumor cell purity, low culture success rate and the like in the traditional method are overcome.

The utility model discloses a hydrothorax knee-chest clinostatism drainage auxiliary pillow which comprises an abdomen decompression pad, a containing groove is formed in the inner wall of the abdomen decompression pad, a first guide groove is formed in the inner wall of one end of the containing groove, second guide grooves are formed in the inner walls of the two sides of the containing groove, and connecting ropes are arranged in the second guide grooves. A head buffer pad is arranged at one end of the connecting rope, the abdomen pressure reducing pad and the head buffer pad are both made of rubber materials, a first fixing belt is arranged on the inner wall of the second guide groove, the front view of the abdomen pressure reducing pad is distributed in an inclined shape, and inserting grooves are formed in the two sides of the abdomen pressure reducing pad; the device is beneficial for helping the old and weak users to borrow strength and keep the knee-chest lying position, and it is guaranteed to a certain extent that the situation that the users shake left and right and fall down due to physical strength and cannot achieve the ideal drainage effect due to the fact that the users cannot insist the time needed by body position drainage is avoided.

This disclosure relates to a method, apparatus, device, and medium for managing dynamic hemodynamic parameters. The method includes: monitoring hemodynamic parameters; wherein the hemodynamic parameters include at least: patient age, maximum pleural fluid level, cardiac index, maximum rate of increase of cardiac index, and maximum rate of increase of myocardial contractility; inputting the hemodynamic parameters into a preset decision tree to output mechanical ventilation time; wherein the decision tree is used to represent the decision relationship between various hemodynamic parameters and mechanical ventilation time; and sending the hemodynamic parameters and mechanical ventilation time to a terminal for display. This disclosure can significantly improve the efficiency of clinical decision-making.

The utility model discloses a chest fluid colorimetric card, including colorimetric card body and a plurality of colorimetric blocks, the middle part of colorimetric card body is equipped with the hollow slot, the hollow slot is along colorimetric card body length direction extension, the left and right two groove walls of hollow slot are along the front -back direction and are equipped with a plurality of mounting slots, a plurality of mounting slots all are along colorimetric card body width direction extension, a plurality of colorimetric blocks are inserted in a plurality of mounting slots one by one, and every colorimetric block can move out in hollow slot, wherein, colorimetric card body surface is equipped with a plurality of transparent windows, a plurality of transparent windows and a plurality of mounting slots are set up one by one to observe the colorimetric block in mounting slot, and every transparent window is equipped with the category mark of corresponding colorimetric block. The utility model discloses simple structure, and the storage is convenient, can carry out the quick contrast to patient chest fluid color, to assist the doctor to judge the patient's condition quickly.

This invention belongs to the field of medical device technology, specifically referring to an implantable pleural shunt drainage system, including a pleural shunt drainage device and a control system. The pleural shunt drainage device includes an implantable device, an inflow catheter, and an outflow catheter. The inflow catheter is placed into the pleural cavity, and the outflow catheter is placed into the bladder cavity or peritoneal cavity. The implantable device incorporates a positive displacement micropump, an inlet pressure sensor, an outlet pressure sensor, and an ambient pressure sensor. Before formal pumping, the control system performs low-volume diagnostic pumping and determines the inlet fluid replenishment status based on the effective drainage volume after short and long pauses, the recovery of inlet pressure, and the recovery of respiratory waveform. Based on this, it switches between intermittent pumping, stops pumping, or allows restricted drainage, and only accumulates the confirmed effective drainage volume. This invention can reduce ineffective pumping and accidental drainage.

The invention discloses a biomarker combination for screening heart failure pleural effusion as well as application, a system, equipment and a medium. The biomarker combination comprises palmitoyl carnitine, stearoyl carnitine, octadecadienoyl carnitine, and the hydrothorax serum concentration ratio of at least one long-chain acyl carnitine in octadecaenoyl carnitine. The biomarker combination provided by the invention has higher clinical value in screening or auxiliary diagnosis of heart failure pleural effusion.

The invention relates to a culture method of TIL from pleural effusion and / or ascites. Specifically, the invention provides the in-vitro culture method of the pleural effusion and / or ascites derived TIL, and the method comprises the following steps: 1) obtaining TIL seed cells from pleural effusion and / or ascites, and 2) sorting the TIL seed cells to obtain intermediate cells which are CD45RA-cells, CD39 + cells, or CD45RA-CD39 + cells.

The application provides a large-scale cell culture method of malignant pleural and peritoneal effusion tumor-associated lymphocytes, and products and applications thereof, and the method comprises the following steps: (1) separating mononuclear cells from the pleural effusion and / or peritoneal effusion of a tumor patient; (2) culturing the mononuclear cells in a culture medium containing IL-2, lymphoblast activation factor and inactivated fetal bovine serum; (3) performing expansion culture by using a culture medium containing IL-2, 0KT-3, IFNγ and inactivated fetal bovine serum; and (4) continuing culture in a WAVE bioreactor by using a cell bag. The method provided by the application has the advantages of fast proliferation, high cell survival rate, good composition of cultured TALs cells, greatly improved culture efficiency compared with conventional methods, and tumor-specific killing effect.

This invention relates to the field of medical device technology, specifically providing a pleural drainage device with monitoring function. This device, through the coordinated design of a first buoyancy component, a second buoyancy component, and a laser beam warning component, can accurately monitor the amount of fluid accumulated in the drainage cavity. When the fluid accumulation in the drainage cavity reaches the warning threshold, a counterweight pushes a horizontal plate downwards, causing a baffle to block the laser detection light path, triggering an audible and visual alarm. This promptly reminds medical staff to replace the drainage device, solving the problems of traditional drainage bottles lacking full-bottle warnings and being prone to pleural fluid overflow or backflow, thus ensuring the safety of the drainage operation.

This application relates to the field of data processing technology, and in particular to an artificial intelligence-based heart failure compensation identification system. The proposed scheme involves acquiring electrocardiogram (ECG) signals, bioimpedance signals, posture information, and chest displacement signals. Based on posture and respiratory information, the bioimpedance signals undergo positional correction and respiratory separation to calculate bioimpedance. Then, the temporal characteristics of the bioimpedance and ECG signals are correlated and modeled to construct an electrohydraulic coupling precursor loop reflecting the relationship between electrophysiology and fluid conduction hysteresis. Topological features such as loop area, direction, number of connections, and morphological stability are extracted. A temporal neural network identification model is used to perform temporal characterization modeling of the topological features, outputting heart failure compensation identification results and management prompts. This application can stably identify the trend of pleural fluid accumulation under postural and respiratory disturbances, enabling intelligent monitoring and proactive intervention for early heart failure compensation abnormalities.

The invention relates to the technical field of data processing, in particular to a heart failure compensation recognition system based on artificial intelligence, and provides the following scheme that electrocardiosignals, biological impedance signals, posture information and thoracic displacement signals are obtained, body position correction and respiration separation are conducted on the biological impedance signals according to the posture and respiration information, and biological impedance is calculated; correlation modeling is conducted on the biological impedance and the time sequence characteristics of the electrocardiosignals, an electro-hydraulic coupling threatening ring reflecting the electrophysiology and liquid conduction lagging relation is constructed, and topological characteristics such as the annular area, the annular direction, the communication number and the morphological stability are extracted; and performing time sequence representation modeling on the topological features through a time sequence neural network recognition model, and outputting a heart failure compensation recognition result and control prompt information. The chest fluid accumulation trend can be stably recognized under the body position and breathing interference, and intelligent monitoring and active intervention on heart failure early-stage compensation abnormity are achieved.