5 results about "Dimethylglycine" patented technology

This invention discloses a apigenin-betaine compound and its preparation method. The compound uses apigenin (Api) as its core, with -O-(CH2) at the 7', 4', and / or 5-position hydroxyl groups. n -N + (CH3)2-CH2COO ‑ Fragment substitution (n=2~12, x=1~3) forms an internal salt-type zwitterionic structure. In preparation, apigenin is first reacted with bromool Br(CH2). n A mitsunobu reaction was performed on OH under triphenylphosphine / dialkyl azodicarbonate conditions to obtain mono / polysubstituted bromoalkoxylated apigenin; subsequently, nucleophilic substitution with N,N-dimethylglycine under alkaline conditions yielded the target product. This structure, possessing both a tunable alkyl chain and a betaine cation / anion pair, significantly enhances the solubility and hydration capacity of apigenin in aqueous / alcoholic media, strengthens its affinity and stability for biomembranes, thereby improving in vivo absorption and distribution and potentially maintaining its antioxidant and anti-inflammatory activities. The method is mild, with a wide solvent and temperature range, suitable for scale-up and formulation applications.

The application belongs to the technical field of photoinitiators and preparation methods, and particularly relates to a preparation method of a macromolecular photoinitiator. The macromolecular photoinitiator is prepared from glycidyl methacrylate, methyl methacrylate, butyl acrylate, hydroxyethyl acrylate, 4-benzoylbenzoic acid, 2-carboxythioxanthone, N,N-dimethylglycine, monomethoxypolyethylene glycol, monohydroxypolycaprolactone and methacrylic acid. In the preparation, a tetra-acrylate polymer containing an epoxy group and a hydroxyl group is first prepared, and then double photoinitiation structure grafting, tertiary amine structure grafting, segment grafting and epoxy closure are sequentially performed, and the feeding amount of each stage is corrected through the initial epoxy value, the first residual epoxy value and the second residual epoxy value. The method connects the benzophenone structure, the thioxanthone structure and the tertiary amine structure to the same polymer molecular chain, reduces the content of unreacted small molecules and the migration and precipitation amount, improves the photocuring gel rate and shortens the surface drying time.

The application provides a method for preparing sodium N,N-dimethylglycinate. The method comprises the following steps: (1) adding a sodium chloroacetate solution into a dimethylamine solution and reacting to obtain a reaction solution; wherein the pH of the reaction is controlled to be greater than 10.5 by adding alkali before or during the reaction; (2) mixing the reaction solution with hydrochloric acid after deamination treatment to obtain a solution containing N,N-dimethylglycinate; (3) reacting the solution containing N,N-dimethylglycinate with sodium hydroxide after impurity removal, solvent crystallization and drying to obtain a sodium N,N-dimethylglycinate product. The method can obtain sodium N,N-dimethylglycinate with high purity, high yield and good stability, and by controlling the drying temperature of the wet product of sodium N,N-dimethylglycinate, the sodium N,N-dimethylglycinate hydrate with good stability can be obtained.

This invention relates to the field of livestock and poultry feed preparation technology, and provides a meat quality improving livestock and poultry feed containing sodium dimethylglycinate and its preparation method, including a basal diet and meat quality improving functional particles dispersed in the basal diet; the meat quality improving functional particles include an adsorption core layer, a fat-soluble isolation layer covering the outside of the adsorption core layer, and a cross-linking protective layer covering the outside of the fat-soluble isolation layer; in this invention, the meat quality improving functional particles adopt a layered structure in which the adsorption core layer, the fat-soluble isolation layer, and the cross-linking protective layer are sequentially coated, and sodium dimethylglycinate and tea polyphenols are pre-loaded in the adsorption core layer formed by montmorillonite, so that the water-soluble functional components, which are originally prone to local distribution differences with the flow of materials, can enter the basal diet in particle form, which is convenient for uniform dispersion in a large batch of feed raw materials.

This invention discloses a biomarker combination for glioma risk screening or auxiliary diagnosis and its application. The biomarker combination comprises creatine, lactate, succinic acid, N,N-dimethylglycine, 2-oxoglutarate, acetic acid, and glutamate. Based on the biomarker combination provided by this invention, a clinical diagnostic model for assessing glioma risk can be constructed using algorithms such as multivariate logistic regression. The constructed clinical diagnostic model has high sensitivity and specificity, and can quickly and accurately assess the glioma risk of subjects, making it suitable for early screening and auxiliary diagnosis of adult gliomas.