104 results about "Dimethylglycine" patented technology

A composition and a method for improving neuromuscular facilitation, also known as “muscle memory,” and enhancing cognitive functions, such as memory and mental focus. The dietary supplement, and the method for the administration thereof, increases acetylcholine levels, which improves neuromuscular facilitation. In various embodiments, factors other than increasing acetylcholine levels within the body further contribute to the overall effect of the dietary supplement composition. In a preferred embodiment, the invention is a composition, and a method for the administration thereof, comprising effective amounts of choline, dimethylaminoethanol, cytidine 5′-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1, vitamin B5, vitamin B6, vitamin B12, folic acid, dimethylglycine, huperzine A, Griffonia simplicifolia extract, and 1-phenylalanine, magnesium stearate, and silicon dioxide.

A process for preparing N,N-Dimethyl Glycine Hydrochloride, comprises treating a chloroacetic acid with aqueous dimethylamine, and then dropping by hydrochloric acid to obtain N,N-dimethyl glycine as well as its hydrochloride salt, wherein decompression process is utilized to assure the product purity and active carbon is employed for cost saving aspect.

The invention provides a gemini quaternary ammonium salt anti-agglomerant, a synthesis method thereof, and a method for inhibiting hydrate agglomeration. The structure of the anti-agglomerant is represented by the formula I, which is shown in the description, wherein in the formula I, the R1 represents a straight-chain alkyl group or a branched alkyl group with a carbon number of 5 to 30, the R2 represents an H atom or a straight-chain alkyl group / branched alkyl group with a carbon number of 1 to 10, and X- represents F-, Cl-, Br-, or I-. The synthesis method comprises the following steps: making N,N-dimethylglycine or N,N-dimethylglycine ester carry out reactions with epoxy chloropropane so as to obtain a quaternary ammonium salt intermediate; and then making the quaternary ammonium salt intermediate carry out reactions with primary amine so as to obtain the anti-agglomerant. The method for inhibiting hydrate agglomeration comprises a step of mixing the gemini quaternary ammonium salt anti-agglomerant with three phases of oil-gas-water. The anti-agglomerant is capable of effectively inhibiting the hydrate from agglomerating, has the characteristics of high efficiency, low consumption, stability, and economy, and is especially suitable for preventing agglomeration of hydrate during the mixed oil-gas-water transportation process.

The invention discloses a degradable gemini quaternary ammonium salt bactericide and a preparation method thereof. The method comprises steps as follows: Step one, N,N-dimethyl glycine, long-chain fatty alcohol (carbon atom numbers are 8, 10, 12, 14, 16 and 18) and benzyl alcohol have an esterification reaction in the presence of a coupling reagent to produce corresponding N,N-dimethyl glycine ester; Step two, the obtained N,N-dimethyl glycine ester and hydrogen chloride, hydrogen bromide or hydrogen iodide react to produce corresponding salt; Step three, products obtained in previous two steps and epichlorohydrin are subjected to quaternization, and degradable gemini quaternary ammonium salt is obtained. The gemini quaternary ammonium salt is more beneficial to adsorption of bacterium surfaces by bactericide molecules due to the electrostatic interaction of two quaternary nitrogen ions contained in molecules and the induction of carbonyl groups in ester groups, so that bacteria are broken through change of permeability of cell walls; hydrophilic groups and hydrophobic groups extend into lipoid layers and protein layers of bacterium cells more conveniently to cause protein denaturation and enzyme deactivation. The bactericide has higher bactericidal ability under the synergistic effect. The gemini quaternary ammonium salt bactericide is efficient, low in toxicity, easily degradable and environment-friendly.

The invention relates to a preparation method of N,N-dimethylglycine and belongs to the field of chemical engineering. The preparation method comprises the following steps of: preparing N,N-dimethyl amino acetonitrile by taking hydroxyacetonitrile and dimethylamine as raw materials, obtaining an N,N-dimethylglycine crude product by alkalizing the reaction liquid with an inorganic base and neutralizing the reaction liquid with an organic acid on the basis of N,N-dimethyl amino acetonitrile reaction liquid, and finally separating and purifying the N,N-dimethylglycine crude product to obtain the high-quality N,N-dimethylglycine product. The preparation method has the advantages that the raw materials are environmentally-friendly and easily available, reaction conditions are mild, the environmental pollution is little, the after-treatment is simple and easy, the production efficiency is high, and the preparation method is suitable for industrial popularization and application.

This invention relates to methods for preparing new menthol derivatives, i.e., N, N-dimethyl menthol glycinate, N, N-diethyl menthol glycinate and N, N-dihydroxyethyl menthol glycinate. This invention comprises three different methods for synthesizing menthol derivatives. Method 1 comprises: reacting chloroacetyl chloride and menthol at room temperature for 1-3 h, and reacting with amine at room temperature for 1-3 h to obtain the target products. Method 2 comprises: refluxing chloroacetic acid and menthol in cyclohexane in the presence of a Lewis acid catalyst for 1-3 h, and reacting with amine at room temperature for 1-3 h to obtain the target products. Method 3 comprises: refluxing N,N-disubstituted glycine and menthol in cyclohexane in the presence of a Lewis acid catalyst for 1-3 h to obtain the target products. The new menthol derivatives can be used as transdermal agents.

The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides having a hydrolyzable covalent bond to a therapeutic agent that includes, etoposide, etoposide 4′-dimethylglycine or doxorubicin. These polypeptide conjugates can be used as vectors to transport the podophyllotoxin derivative across the blood brain barrier (BBB) or into particular cell types such as ovary, liver, lung, or kidney. The invention also relates to pharmaceutical compositions that include the compounds of the invention and to uses thereof in methods of treatment.

The invention relates to preparation of N, N-dimethyl glycine ester chemical products, particularly relates to a preparation method of N,N-dimethyl glycine ester based on silica gel sulfonic acid serving as a catalyst, and belongs to the field of chemical industries. The preparation method is characterized in that carboxylic acid and alcohol are used as raw materials for carrying out esterification reaction so as to obtain the N,N-dimethyl glycine ester, the catalyst for esterification reaction is the silica gel sulfonic acid, the carboxylic acid is N,N-dimethyl glycine, and the alcohol is fatty alcohol with 1-12 carbon atoms. The synthesis of the silica gel sulfonic acid serving as the catalyst involved in the invention is simple, raw materials for synthesis of the catalyst are cheap and easily available, and the catalyst has high catalytic activity; the catalyst is recycled and reused through simple filtration, so that the production cost is saved; the corrosion of sulfuric acid, phosphoric acid and the like to equipment is avoided; by adopting the technology, the yield is high, and the conversion rate can reach above 95%; after completion of reaction, the follow-up treatment is simple; the atom economy in the whole reaction process is good, and no other waste products are generated except for water.

The invention discloses novel markers for predicting the efficacy of pemetrexed-platinum combined treatment on non-small cell lung cancer and its application. Specifically, the invention provides a set of the markers for predicting the efficacy of pemetrexed-platinum combined treatment on non-small cell lung cancer and its use in a product for predicting the efficacy of pemetrexed-platinum combined treatment on non-small cell lung cancer. The markers comprise hypotaurine, uridine, dodecanoyl carnitine, choline, dimethyl glycine, nicotinamide and hexadecanoyl carnitine. The markers and a modelwith the markers can predict the efficacy of the chemotherapy scheme before the patient undergoes chemotherapy and has sensitivity of 90.8% and specificity of 79.5%.

Provided are a marker for determining sensitivity to an anticancer agent capable of distinguishing a therapeutic response of an individual patient and a novel means for a cancer therapy using the marker. The marker for determining sensitivity to an anticancer agent contains a substance in a metabolic pathway in which L-phenylalanine and / or N,N-dimethyl glycine are / is involved.

The invention discloses antistatic spinning paste and a preparation method thereof. The antistatic spinning paste is prepared from the following components in parts by weight: 60-70 parts of acrylonitrile fibers, 30-40 parts of polyethylene glycol, 12-16 parts of mannitol, 8-12 parts of vinylidene chloride, 5-8 parts of carboxymethyl cellulose, 3-5 parts of epoxypolysilicone acrylate, 2-3 parts of N-dodecyl-N,N-dimethylglycine, 0.5-1 part of allylthiourea, 0.5-1 part of polydimethylsiloxane divalent quaternary ammonium salt, 0.2-0.8 part of 2-methyl-3-hydroxyl-4-methoxyanthraquinone, 0.2-0.6 part of magnesium aluminosilicate and 0.02-0.08 part of kaempferol. The invention further provides the preparation method of the antistatic spinning paste.

A nutritional supplement is disclosed and which includes an ingestible mixture of Magnesium Chelate, Malic Acid, Dimethylglycine HCL and Niacinamide in amounts which, when ingested, reduces the occurrence of chronic exertional compartment syndrome in an athlete.

The invention provides a foaming agent for tertiary oil recovery and a preparation method thereof. The foaming agent includes: 30-60% of N-dodecyl-N, N-dimethylglycine; 10-40% of sodium alpha-olefin sulfonate (AOS); 10-40% of carboxymethyl cellulose; and 10-60% of water. The preparation method includes: adding the N-dodecyl-N, N-dimethylglycine and sodium alpha-olefin sulfonate (AOS) involved in the formula into a reaction kettle, conducting stirring and simultaneously adding part of water and sodium carboxymethyl cellulose into the reaction kettle, and performing dissolving, when all components in the reaction kettle are dissloved, adding the remaining amount of water into the reaction kettle, and stirring the mixture evenly to obtain a finished product of foaming agent. The foaming system provided by the invention can well reduce the surface tension under different mineralization degrees, and can lower the interfacial tension of crude oil to 0.5*10<-2>mN / m. Also after 3 months of storage at 80DEG C, the viscosity retention rate is more than 90%, and the foaming agent has very good stability.

The invention belongs to the field of chemical engineering, and relates to a one-pot method of preparing N,N-dimethyl glycinate. The method comprises the steps that N,N-dimethyl aminoacetonitrile, straight-chain or branched-chain fatty alcohol of 1-12 carbon atoms, and water serve as raw materials, are heated, and react sufficiently to form N,N-dimethyl glycinate under catalysis of cerium oxide. According to the method, the raw materials and a catalyst are conducted in a pot; a yield is high; operating steps are simple; equipment contacted by reactants is less; the contaminated probability is low; no chlorine ion is introduced in a reaction; and used catalyst cerium oxide is easy to obtain, cheap in price and easy to recover and recycle, and is suitable for industrial scale production.

The invention discloses a N,N-dimethylglycine organic acid polyvalent metal ion compound salt, and a solvate thereof, and application thereof in manufacturing of novel feed additive, and application in manufacturing of feed. The invention also discloses a feeding composition including the N,N-dimethylglycine organic acid polyvalent metal ion compound salt or the solvate thereof. Applying the N,N-dimethylglycine organic acid polyvalent metal ion compound salt or the solvate in animal farming industry has effects of improving animal weight gain rate, reducing feed conversion ratio and other animal production performance, and the N,N-dimethylglycine organic acid polyvalent metal ion compound salt has similar or better effect than that of N,N-dimethylglycine sodium salt.

The invention discloses a foam extinguishing agent. The foam extinguishing agent is composed of, by mass, 3%-5% of trimethyl-1-propanaminium iodide, 3%-5% of perfluorooctylbetaine, 3%-5% of ethylene glycol, 3%-5% of urea, 5%-8% of sodium 2-olefinsulfonate, 5%-8% of lauryl sodium sulfate, 5%-8% of N-Dodecyl-N,N-Dimethylglycine and the balance water. The invention further discloses an application of the foam extinguishing agent. A film generated by the foam extinguishing agent is large in thickness and high in stability, the fire extinguishing speed is high, and the fire extinguishing effect is good.

The invention discloses a low-foam fountain solution. The low-foam fountain solution is characterized by being composed of, by weight, 2-10 parts of fatty acid methyl ester ethoxylate sodium sulfonate, 1-2 parts of dimethyl carbonate, 1-3 parts of percarbamide, 1-3 parts of limonene, 1-3 parts of sodium alkyl naphthalene sulfonate, 1-5 parts of dimethylglycine, 0.5-1 part of heteroauxin, 1-3 parts of geranialdehyde, 1-3 parts of laurinol, 1-3 parts of polymaleic anhydride, 1-2 parts of palm wax, 5-10 parts of assistants and 30-50 parts of water. When the fountain solution is used, foam is avoided, cost is low, the wetting effect is good, an image and a text are clear and high in restoration degree, the plate cleaning capacity is high, and the printing effect is stable.

The invention is concerned with a method and a composition for treating or preventing catabolism or of stimulating anabolism in a mammal undergoing metabolic stress. The method comprises administering to the mammal a composition containing methyl donors selected from the group consisting of L-serine, methionine, choline, phosphatidyl choline, betaine, dimethylglycine, sarcosine, methylated folates, S-adenosyl methionine, thymidine triphosphate, adenosine triphosphate and optionally methyl acceptors selected from the group consisting of L-glycine, ethanolamine, phosphatidyl ethanolamine, folate, ribose, wherein the total molar amount of methyl donors delivered by the method exceeds the total molar amount of methyl acceptors delivered by the method by at least 0.18 mmol per kg of body weight per day.

The invention discloses an N,N-dimethylglycine hydrochloride preparation method suitable for industrial production. The N,N-dimethylglycine hydrochloride preparation method comprises the following steps of putting an organic solvent into an autoclave, adding chloroacetic acid into the organic solvent, carrying out stirring until full dissolution of chloroacetic acid, adding sodium iodide as a catalyst into the solution, slowly feeding dry dimethylamine gas into the mixed solution, carrying out a reaction process under reaction pressure of 0.3-0.7MPa at a temperature of 65-75 DEG C for 4-6h, and carrying out condensation, cooling crystallization, centrifugation and drying to obtain N,N-dimethylglycine hydrochloride. The N,N-dimethylglycine hydrochloride preparation method has simple processes, is convenient for operation, realizes high product purity, has a high yield and is suitable for industrial production.

The invention provides anti-inflammatory homalocladium platycladium soap. The soap is prepared from raw materials in parts by weight as follows: 2-4 parts of a homalocladium platycladium extract, 4-6 parts of a common calanthe herb extract, 2-4 parts of paeoniflorin, 1-3 parts of ursolic acid, 10-20 parts of hexadecyl(sulfophenoxy)benzenesulfonic acid disodium salt, 8-10 parts of coconut oil fatty acid monoethanolamide, 10-16 parts of N-cocamidopropyl-N,N-dimethylglycine inner salt, 10-14 parts of hydrogenated cottonseed glyceride sulfosuccinate disodium salt, 2-4 parts of caprylic capric triglycerride and 20-30 parts of distilled water. The soap is fine, smooth, stable, mild in performance, low in skin irritation, capable of playing an anti-inflammatory effect after other extracts are added, environment-friendly, good in usage effect and convenient.

The invention discloses a methyltransferase gene in a betaine synthetic pathway and application thereof. A method for preparing the methyltransferase gene comprises the following steps of: cloning a glycylsarcosine N-methyltransferase gene (ApGSMT2) and a dimethylglycine N-methyltransferase gene (ApDMT2) from aphanothece halophytica; substituting a codon which is in the ApGSMT2 and the ApDMT2 andis relatively low in appearance chance in a higher plant by a codon which is favorable by the higher plant so as to generate the ApGSMT2d gene and the ApDMT2d gene; and constructing series genes of which the encoding products are respectively positioned in chondriosomes by the method for fusing a protein-positioned guide peptide sequence and the methyltransferase gene. The ApGSMT2 uses glycine and creatine as substrates to catalyze glycine methylation, the ApDMT catalyzes the methylation of dimethylglycine, and the ApGSMT2 and the ApDMT coordinate to catalyze the synthesis of the glycine betaine. The ApGSMT2 / ApDMT2 or modifying genes thereof are transplanted into crops, such as corns, wheat, cotton, bean, and tobacco in a synergistic way, and high concentration of glycine betaine is accumulatd ein cells, so that the stress resistance of plants is obviously improved.

The invention relates to a method for recycling glyphosate from glyphosate mother liquid. The glyphosate mother liquid contains N,N-dimethylglycine, sulfate ion, ferric ion and impurities of arsenic ion, lead ion, mercury ion, and the like. The method comprises the following steps: adopting anion absorbent resin, in particular to anion absorbent resin with alkalescence to carry out absorption andseparation including resin separation by means of parallel connection or series connection to separate the glyphosate from the mother liquid, thereby improving the product yield, effectively reducingthe cost and reducing pollution.

The invention provides a modified chitosan and a preparation method thereof. The preparation method comprises following steps: mixing chitosan and N,N-dimethyl glycine in a solvent, carrying out reactions under the action of a catalyst; after reactions, cooling, adjusting the pH to 7, washing, carrying out liquid separation and extraction, performing distillation by a rotary evaporator to obtain viscous liquid; adding the viscous liquid into an organic solvent, slowly adding chloro-propyl silane, heating, carrying out refluxing for 5 to 10 hours to obtain a product, using a dialysis bag to carry out dialysis, concentrating the product, and drying to obtain the final product namely modified chitosan. The test results show that the prepared modified chitosan can kill staphylococcus aureus, escherichia coli and candida albicans; the sterilization rates all reach 99% or more; and the modified chitosan does not trigger skin allergy.

The invention discloses a high-temperature-resistance gas well liquid anti-salt foam scrubbing agent, which aims to solve the problems that an existing foam scrubbing agent cannot meet the requirements of low cost, high solubility, high temperature resistance, salt resistance and remarkable foaming and foam-stabling performance. The foam scrubbing agent is prepared from the following components inparts by weight: 3-8 parts of N,N',N''-pentasodium diethylenetriaminepentaacetate, 4-9 parts of N-dodecyl-N,N-dimethylglycine, 2-5 parts of sodium dodecyl benzene sulfonate, 1-2 parts of galactomannan and 5-10 parts of dodecyl-2-hydroxy-1-proply sulfobetaine. The high-temperature-resistance gas well liquid anti-salt foam scrubbing agent can effectively achieve the effects of low cost, high solubility, high temperature resistance, salt resistance and remarkable foaming, and has a remarkable foam stabilizing effect.

The invention relates to a hydrothorax exosome metabolite combination, a kit and a method for diagnosing tuberculous pleurisy. The hydrothorax exosome metabolite combination for diagnosing the tuberculous pleurisy is prepared from dimethylglycine, choline, acyl carnitine with the ratio of 10: 2, phosphatidylcholine with the ratio of 35: 6, phosphatidylcholine o with the ratio of -36: 0, phosphatidylethanolamine with the ratio of 33: 2, sphingomyelin with the ratio of 28: 1 and oleic acid. The kit for diagnosing the tuberculous pleurisy comprises an internal standard substance required for detecting the concentration of the metabolites in the hydrothorax exosome sample extraction solution. A combined marker provided by the invention has the characteristics of high sensitivity and high specificity for the diagnosis of tuberculous pleurisy, and meanwhile, can be complementary with the traditional marker adenosine deaminase, and can be used for the auxiliary diagnosis of the tuberculous pleurisy by being combined with the traditional marker adenosine deaminase.

The invention discloses a preparation method of N, N-dimethylglycine for industrial production. The preparation method comprises the following steps of S1, chloroacetic acid solution preparation: adding chloroacetic acid into water at a normal temperature to obtain a chloroacetic acid solution, S2, reaction of the chloroacetic acid solution and dimethylamine: adding the chloroacetic acid solution into a dimethylamine agueous solution according to a more ratio of chloroacetic acid to dimethylamine of 1: 2.5 to 1: 5, controlling a temperature in 20-70 DEG C, and then carrying out a thermal insulation reaction process at the temperature of 20-70 DEG C for 2-5h, S3, redundant dimethylamine removal: removing unreacted dimethylamine after the thermal insulation reaction, and S4, condensation crystallization, centrifugation and drying: concentrating the solution obtained by the step S3 to obtain a lot of white crystals, carrying out cooling to a temperature of 25 DEG C, and carrying out centrifugation and drying. The preparation method adopts the easily-available and cheap raw materials, has simple processes, is convenient for operation, has no purification difficulty and is suitable for large-scale industrial production.

The invention discloses a mixture with a sterilizing effect. The main effective ingredients of the mixture is camphor tree essential oil and ephedrine; the camphor tree essential oil is prepared by utilizing a 2-Methylalanine and calcium citrate synergistic distillation extracting technology, the ephedrine is prepared by utilizing an N, N-dimethylglycine and zinc acetate synergistic ultrasound assisted enzymatic technology, and the obtained product is high in yield and good in purity. The mixture is prepared by binary mixing of effective ingredients, including a plant source compound camphor tree essential oil and a chemical agent ephedrine, in a ratio of 1:20-20:1, and the mixture is obvious in synergism and high in bacteriostatic activity at the ratio of 1:5-5:1. The mixture has the benefits that camphor tree essential oil and ephedrine can be prepared to be preparations such as missible oil, emulsion in water, suspension emulsio and water dispersible granules, to be used for controlling crop diseases such as gray mold, gibberellic disease, virus disease, leaf mold, brown spot, ring spot, oxysporum and epidemic disease.

The invention discloses an oat hydrating moisturizing sleeping facial mask. The formula of the facial mask comprises the following raw materials in parts by weight: 10 parts of 1, 3-butanediol, 0.1 part of EDTA disodium, 0.2 part of allantoin, 0.5 part of acrylic acid (ester) / C10-30 alkanol acrylic acid cross-linked polymer, 0.1 part of triethanolamine, 10 parts of dimethyl glycine, 0.1 part of sodium hyaluronate, 1.5 part of caprylin, 2 parts of dehydrated xylitol, and 100 parts of purified water. The amounts and physicochemical properties of all the raw materials produce a synergistic effect, so that the effecta of deep moisturizing, whiteni ng and compacting are achieved. The pH value of the facial mask is approximate to that of human body skins, and the facial mask has no irritability to skin; users obviously feel comfortable, soft and no greasy after using the facial mask, and the facial mask has obvious effects of compacting, moisturizing, young keeping and skin protection.