47 results about "Apigenin" patented technology

The invention relates to the technical field of natural medicine, in particular to a composition with a nerve protection function, a lavender extract and a preparation method and application of the lavender extract, and the composition with the nerve protection function comprises luteolin-7-O-glucoside, apigenin-7-O-glucoside, salvianolic acid A and rosmarinic acid. The lavender extract contains luteolin-7-O-glucoside, apigenin-7-O-glucoside, salvianolic acid A and rosmarinic acid, and is prepared according to the following method: adding a required amount of an extraction solvent into crushed lavender, heating, refluxing and extracting, concentrating and drying the extract, and concentrating to obtain the lavender extract. The lavender extract containing the composition with the nerve protection function is obtained. The composition with the neuroprotection function and the lavender extract have good effects in BV-2 cell viability influence experiments and zebra fish Alzheimer disease model experiments, and a new solution is provided for research of drugs for preventing and treating Alzheimer disease.

The present invention relates to a coloring composition comprising as a coloring agent a combination of: an extract A of the aerial parts of Lawsonia inermis containing between 7 and 60% by weight of lawsone in relation to the total weight of the dry extract, wherein the lawsone results especially from the enzymatic hydrolysis of glycosylated derivatives of lawsone, wherein said extract further comprises luteolin, apigenin and 2,3,4,6-tetrahydroxyacetophenone; and at least one other coloring agent B derived from a dye plant other than Lawsonia inermis, from microorganisms or from microalgae.

The invention discloses a chrysin breast injectant prescription and a preparation method thereof, a main drug of a veterinary chrysin injectant comprises chrysin, after an emulsifier and a suspending aid with an optimized ratio are added and dispersed, uniform mixing is easy, the drug components are stably and uniformly dispersed in soybean oil, and the sustained release effect is significant. Chrysin as a natural substance capable of relieving cow mastitis is wide in source, green and effective; according to the prescription, chrysin is independently used, so that the injury of inflammation to mammary tissues of dairy cows can be relieved, and the mammary gland function recovery is promoted.

The invention provides a cough-relieving and phlegm-eliminating composition and a preparation method thereof. The cough-relieving and phlegm-eliminating composition is prepared from the following raw materials: anhydrous morphine, anhydrous codeine phosphate, apigenin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, trans-anethole, camphor and sodium benzoate. The composition further comprises a luffa stem extract, an atractylodes lancea rhizome extract and a radix ranunculi ternati bark extract. The cough-relieving and phlegm-eliminating composition provided by the invention has the advantages of few impurities, clear and remarkable drug effect and small side effect. Under the action of the core antitussive drug, three plant extracts of luffa stem, Atractylodes lancea and Ranunculus ternatus Thunb. Are creatively added, so that the phlegm eliminating capacity and the overall antitussive effect of the whole formula are remarkably enhanced. The cough-relieving and phlegm-eliminating composition disclosed by the invention realizes the synergistic interaction of '1 + 1 + 1gt, 3' on the core indexes of inhibiting the cough frequency, prolonging the cough latency period, promoting sputum excretion and the like, and realizes the cough-relieving and phlegm-eliminating effects of treating both symptoms and root causes through the multi-target-point and multi-mechanism synergistic effect.

The invention belongs to the technical field of medicines, and particularly relates to an active ingredient composition for treating xerophthalmia and muscae volitantes as well as a preparation method and application of the active ingredient composition. The composition is prepared from lycium barbarum polysaccharide, zeaxanthine, apigenin, luteolin, zinc gluconate, ophiopogon japonicus polysaccharide, ophiopogonin B, paeoniflorin and gallic acid according to a specific weight part ratio, all the active ingredients have a synergistic effect, the ocular surface microenvironment is improved, the vitreous opacity progress is inhibited, eye tissue damage is repaired, and the eye quality is improved. The synergistic treatment effect on the xerophthalmia and the muscae volitantes is achieved, and the symptoms such as eye dryness, eye acerbity, lacrimal secretion insufficiency, black shadow fluttering and blurred vision can be effectively relieved.

The invention relates to bacillus velezensis JT-14 with high yield of terpene flavor components as well as a screening method and application of the bacillus velezensis JT-14, and belongs to the technical field of microorganisms and fermentation. The preservation time of the bacillus velezensis JT-14 with high yield of terpene flavor components is June 26, 2025, the preservation unit is Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC 66597. The bacillus velezensis JT-14 screened by the invention has good safety, and can generate monoterpenoid substances (alpha-terpilenol, linalool, citronellol, carveol and the like) with flower fragrance, elecampane and faint scent and sesquiterpenoid substances (alpha-panaxene, cubene, elemol and gamma-apigene) with herbal fragrance in a substrate fermentation experiment. When the bacillus velezensis JT-14 is applied to tobacco leaf fermentation, the aroma of the aroma raw material obtained through fermentation can be integrally improved, and the aroma is softer.

The inventors' primary objective was to provide a technology that suppresses inflammation, particularly in aging tissues. [Solution] The above problem can be solved by a composition containing at least one selected from the group consisting of genistein, quercetin, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof.

The invention provides a method for detecting the contents of multiple index components of a coughing oral liquid, which comprises the following steps of: determining the contents of nine key pharmacodynamic index components, namely ephedrine hydrochloride, pseudoephedrine hydrochloride, apiose liquiritin, isoliquiritin, baicalin, huperzin A glycoside, wogonin, baicalein and wogonin; the detection method has the advantages of simplicity and convenience in operation, high stability, high pertinence and high practicability, can be used as a detection and evaluation method for production and internal quality components of the coughing oral liquid, and has a good market application prospect.

The invention discloses an insecticidal composition of a compound medicament for preventing and controlling bemisia tabaci, pea aphid and corn aphid, and belongs to the technical field of pesticides. The invention relates to a plant source compound huperzine A, apigenin and psoralen B, which are respectively compounded with five different emulsifiers to form the plant source compound huperzine A, apigenin and psoralen B, and the emulsifiers mainly comprise any one of sulfosuccinic acid-1, 4-dioctyl ester, fatty alcohol-polyoxyethylene ether, NP-10, Tween 20 and Tween 500. Huperzine A, apigenin, psoralen B and emulsifiers with different concentrations are compounded to obtain the insecticide composition, and the synergistic effect is achieved through the interaction of the emulsifiers and the compound. The compound pesticide is used for preventing and controlling horticultural crop pests such as bemisia tabaci and aphids, the usage amount of the pesticide can be reduced, pesticide residues on crops can be reduced, the preparation process is simple, raw materials are input, all raw materials are converted into finished products, no pollution is caused to the environment, and wide market prospects are achieved.

Disclosed are multi-peptide compositions and / or methods of use of the multi-peptide compositions for subjects suffering from or at risk for a neural disease. Pharmaceutically acceptable embodiments administered subjects may treat or prevent the neural disease. In certain embodiments, a flavonoid compound is administered in conjunction with a peptide. In still other embodiments, a porosome complex is administered with the peptide and / or with the flavonoid compound.

The application relates to a method for bioconversion of naringenin to produce apigenin and dihydroquercetin, belonging to the field of biotechnology and food engineering, and comprising the following steps: (1) screening and mutagenic breeding of high-yield strains; (2) high-density fermentation for converting naringenin into apigenin and dihydroquercetin; and (3) extraction and refining to obtain high-purity apigenin and dihydroquercetin. Rhodococcus opacus OMK-104 bioconversion of cheap and easily available naringenin into high-value apigenin and dihydroquercetin has high conversion rate and high titer of apigenin and dihydroquercetin, and has a positive effect on reducing the production cost of apigenin and dihydroquercetin and promoting large-scale commercial application of apigenin and dihydroquercetin.

The present application relates to a kind of construction methods of vinegar jinyinhua standard decoction HPLC characteristic map, the present application adopts high performance liquid chromatography, Kromasil 100-5C18 chromatographic column, with methanol and 0.05% phosphoric acid aqueous solution mixture as mobile phase gradient elution is carried out, under the condition that flow rate is 1.0mL / min, column temperature is 35 ℃, detection wavelength is 238nm, establish vinegar jinyinhua standard decoction HPLC characteristic map, chromatogram is matched by "Chinese medicine chromatographic fingerprint similarity evaluation system" (2004A edition) peak, 14 common peaks are defined, 6 characteristic peaks are identified as jinyinhua-5-O-madder glycoside, luteolin, tiliroside, apigenin, hydroxyl jinyinhua and jinyinhua, and the similarity of 21 batches of vinegar jinyinhua standard decoction characteristic map is evaluated, sample similarity result is above 0.95;The HPLC characteristic map analysis method of vinegar jinyinhua standard decoction constructed by the present application is simple, accurate, reproducible, provides methodological basis for the quality evaluation and control of vinegar jinyinhua formula granules system.

In one embodiment, the present invention provides a method for producing an extracted composition capable of efficiently extracting a polyphenol such as apigenin and / or an essential oil component such as spiroether from a harvested herbaceous plant. In one embodiment, the present invention relates to a method for producing an extraction composition, the method comprising the following steps (1) and (2). (1) A step of applying oxidative stress to harvested herbaceous plants and storing the herbaceous plants. And (2) a step for obtaining an extract from the herbaceous plant after step (1). The present invention also relates to a method for producing an external product or a food product using the method for producing the extraction composition, the extraction composition, the external product or the food product.

The invention relates to the technical field of quality control of Chinese patent medicines, in particular to a method for simultaneously determining the content of new tripterygium ford and euscaphis japonica acid in a tripterygium wilfordii preparation, which comprises the following specific steps: taking the tripterygium wilfordii preparation, crushing, precisely weighing, adding methanol for extraction, and filtering to obtain a test solution A; adding methanol into the test solution A to dilute the test solution A by 8-10 times to obtain a test solution B; precisely weighing a proper amount of a new tripterygium ford reference substance and a proper amount of a euscaphis japonica acid reference substance, adding methanol for dissolving to obtain a reference substance stock solution, and diluting the reference substance stock solution to obtain a series of reference substance solutions with different concentrations; detecting the test solution A and the test solution B by using UPLC-MS / MS, and quantifying by using a standard curve established by the reference substance solution; according to the method provided by the invention, rapid quantitative analysis can be carried out on the neotripterygium wilfordii fudine and euscaphis japonica acid in the tripterygium wilfordii preparation, and a foundation is laid for improving the quality of the tripterygium wilfordii preparation.

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition with a qi-blood tonifying effect and a pharmaceutical preparation and application thereof. The composition is prepared from the following raw materials in parts by weight: 0.2 to 1 part of tangeretin, 0.2 to 5 parts of nobiletin, 0.05 to 0.2 part of lobetyolin, 0.1 to 1 part of allantoin, 0.1 to 1 part of liquiritigenin, 0.1 to 1 part of alnus ketone, 0.02 to 0.2 part of rutin, 0.2 to 2 parts of apiose liquiritin and 0.1 to 1 part of ammonium glycyrrhizinate. The traditional Chinese medicine composition has the remarkable effects of replenishing blood and qi, treating anemia and resisting fatigue.

The invention provides a detection method of Ruyi golden yellow powder, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, apigenin is used as a reference substance, the content of total flavonoids in Ruyi golden yellow powder in terms of apigenin is calculated by preparing a reference substance solution, establishing a standard curve and determining the absorbance of a sample to be detected by adopting ultraviolet-visible spectrophotometry, if the content of apigenin in Ruyi golden yellow powder to be detected is not lower than 20 micrograms / g, the detection is qualified, otherwise, the detection is qualified, and the content of total flavonoids in Ruyi golden yellow powder to be detected is not lower than 20 micrograms / g. Unqualified products are obtained. The method can be used for objectively, comprehensively and accurately evaluating the quality of the Ruyi golden yellow powder, and has important significance on guaranteeing the quality of the product while guaranteeing the curative effect of the product.

The invention discloses an HPLC specific chromatogram and component content detection method of a radix astragali-lepidii heart-strengthening capsule, and belongs to the technical field of quality control of traditional Chinese medicines. The establishment method of the HPLC characteristic chromatogram of the radix astragali-lepidium meyenii heart-strengthening capsule comprises the following steps: preparing a test solution from the content of the radix astragali-lepidium meyenii heart-strengthening capsule; the preparation method comprises the following steps: respectively weighing adenosine, guanosine, tanshinol, protocatechuic acid, protocatechuic aldehyde, catechin, 4-methoxysalicylaldehyde, calycosin glucoside, narirutin, hesperidin, rosmarinic acid, alkannic acid, salvianolic acid B, apigenin and formononetin, and preparing a mixed reference solution; and carrying out HPLC detection analysis on the test solution and the mixed reference substance solution to obtain the HPLC characteristic chromatogram of the astragalus membranaceus-lepidium monnieri heart-strengthening capsule. The method has the advantages of strong specificity, high precision, good stability and good repeatability, can realize characteristic spectrum identification and multi-component content control of the astragalus membranaceus-lepidium monnieri heart-strengthening capsule at the same time, and provides a reliable basis for production quality supervision and clinical medication safety of the astragalus membranaceus-lepidium monnieri heart-strengthening capsule.

This invention discloses the application of a flavonoid compound from Citrus aurantium, specifically the application of a flavonoid compound from Citrus aurantium or its physiologically acceptable salt in the preparation of anti-inflammatory and / or therapeutic drugs for diseases related to lactate dehydrogenase release. The flavonoid compound from Citrus aurantium has the structural formula shown in Formula I, wherein R1 is selected from methoxy, hydrogen, ethoxy, or hydroxy; R2 is selected from methoxy, hydrogen, ethoxy, or hydroxy; R3 is selected from methoxy, hydrogen, ethoxy, or hydroxy; R4 is selected from methoxy, hydrogen, ethoxy, or hydroxy; R5 is selected from methoxy, hydrogen, ethoxy, or hydroxy; R6 is selected from methoxy, hydrogen, ethoxy, or hydroxy; and the C2-C3 bond is a double bond or a saturated bond. This invention clarifies that among the flavonoid compounds from Citrus aurantium, isopyroside, apigenin, norihesperidin, hesperidin, and isohesperidin can significantly inhibit LPS-induced LDH release in HL-1 cells and can serve as lead compounds for antiseptic myocardial injury drugs.

The invention belongs to the technical field of medicines, and discloses a chrysin and sophoridine eutectic, a preparation method, a composition and application thereof. Specifically, the invention discloses an eutectic substance formed by combining chrysin and sophoridine through a non-covalent bond, and the molecular formula of the eutectic substance is C15H10O4.C15H24N2O, the invention relates to a preparation method of a chrysin and sophoridine eutectic. The chrysin and sophoridine eutectic is applied to preparation of drugs for preventing and treating cardiovascular diseases, resisting oxidation, resisting cancer, resisting virus, resisting hypertension, reducing blood fat, reducing blood sugar, resisting bacteria, diminishing inflammation and enhancing radiotherapy sensitivity.

The invention discloses a quality control method of peony leaves, and relates to the technical field of traditional Chinese medicine identification. The quality control method adopts thin layer chromatography to identify paeoniflorin in peony leaves, adopts spectrophotometry to determine total flavonoids in the peony leaves, and adopts high performance liquid chromatography to determine the content of paeoniflorin and apigenin 7-O-glucoside in the peony tablets. The quality control method of the peony leaves can be used for quality control of the peony leaves, is good in precision, sensitivity and stability, ensures uniformity, stability, effectiveness and controllability of product quality, and effectively solves the problems of peony leaf quality control standardization, medicine stability, undefined period of validity and hyperuricemia treatment requirements.

The invention belongs to the technical field of cosmetics, and particularly relates to a skin repairing composition as well as a preparation method and application thereof. The skin repair composition consists of a premix and a bletilla striata water extract, the premix is prepared from naringenin chalcone, apigenin, L-glutamic acid, 2-aminoisobutyric acid, procyanidine and caffeic acid according to the mass ratio of (0.001 to 0.005) to (0.01 to 0.05) to (0.01 to 0.05) to (0.02 to 0.06) to (0.01 to 0.03) to (0.04 to 0.08); the mass ratio of the premix to the water extract of the bletilla striata flowers is (0.1-0.3): (0.0075-0.15). The in-vitro antioxidant activity of the obtained skin repair composition is remarkably improved, the intracellular ROS level is effectively reduced, oxidative stress injury is relieved, secretion of inflammatory factors in cells can be remarkably reduced, the cells are protected against inflammatory injury caused by UVB, and the skin repair composition further has remarkable anti-aging and moisturizing activity.

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.

The invention discloses a flavone synthetase from pogostemon cablin and application of the flavone synthetase in synthesis of apigenin from recombinant pichia pastoris. The amino acid sequence of the flavone synthetase is shown as SEQ ID NO.1. The invention further provides application of the flavone synthetase or the recombinant pichia pastoris in catalytic synthesis of the apigenin. According to the catalysis, the recombinant pichia pastoris is subjected to induced culture by using a naringenin-containing methanol solution as a unique carbon source, and naringenin enters cells and is converted into apigenin under the catalysis of flavone synthetase. The pogostemon cablin-sourced flavone synthetase has the advantages that 6-8 genes which do not need an apigenin de novo synthesis pathway are provided, subsequent optimization regulation and modification are facilitated, and yield is increased to reach entry-level industrial application. The application of the pogostemon cablin-sourced flavone synthetase in synthesis of apigenin from recombinant pichia pastoris is also provided.

Abstract Provided are compositions for protecting the hair from UV radiation and promoting hair growth. These compositions are in the form of a hair serum comprising an aqueous base; a UV filter comprising terephthalylidene dicamphor sulfonic acid and phenylbenzimidazole sulfonic acid sufficient to achieve an SPF of at least 15; at least one hair-thickening agent comprising biotinoyl tripeptide-1, niacinamide, and apigenin; and at least one humectant or emulsifier. Abstract

This invention discloses a highly efficient method for the enrichment and separation of isoflavones from kudzu root, belonging to the field of traditional Chinese medicine extraction and separation technology. The method includes: adsorbing and enriching kudzu root juice using HP-20 macroporous adsorption resin, optimizing the sample loading and elution conditions, and eluting with 50% ethanol to obtain a crude isoflavone extract; then separating the crude extract using high-speed countercurrent chromatography, employing a solvent system of ethyl acetate-n-butanol-water with a volume ratio of 2:1:3 to achieve efficient and simultaneous separation of four isoflavone components: puerarin, 3′-methoxypuerarin, puerarin apigenin, and daidzein. This invention features a simple process, low solvent consumption, and high separation efficiency, simultaneously obtaining multiple high-purity isoflavone monomers, making it suitable for large-scale production.

The invention relates to the use of scyllo-inositol alone or in combination with other active ingredients including the flavone apigenin to support cognitive health in a subject that takes the product or combination product. The invention relates to compositions comprising scyllo-inositol alone or in combination with other agents including but not limited to a flavone or other substance that upregulates or prevents the downregulation of aquaporin 4 channels. The compositions, which are inclusive of oral dosage forms such as tablets or capsules, are provided to the subject which is inclusive of humans or other mammals such as dogs or cats or other animals in need of cognitive improvement. The combination product(s) break up amyloid beta aggregates and promote the clearance of amyloid beta fibrils from the glymphatic system.

The invention discloses a sculellaria barbata-sourced flavonoid glycosyl transferase and application thereof, the flavonoid glycosyl transferase can take flavonoid compounds (apigenin, baicalein, scutellarein and the like) as a substrate, and simultaneously catalyzes the 5-OH site and the 7-OH site of the substrate to carry out an oxygen glycosylation reaction, so that the flavonoid compounds (apigenin, baicalein, scutellarein and the like) can be obtained. The enzyme comprises an amino acid sequence shown in SEQ ID No.2 or variants with the same activity. Besides, the mutant is obtained through site-specific mutagenesis (for example, threonine at the 276th site is mutated into serine), the 5-O-glycosylation activity is remarkably enhanced, an important enzyme element is provided for efficient synthesis of rare flavone 5-O glycoside, and the mutant has wide application prospects in synthetic biology and drug development.

The main purpose of the present inventors is to provide a technique for suppressing inflammation, in particular, in aging tissues within the oral cavity.　The present inventors have found that an oral composition containing at least one selected from the group consisting of β-glycyrrhetinic acid, glycyrrhizic acid, ascorbic acid, tocopherol nicotinate, tocopherol acetate, pyridoxine, cobalamin, retinol, retinol acetate, riboflavin, phylloquinone, calciferol, anthraquinone, menaquinone-4, and L-aspartic acid, and chemically acceptable salts thereof, quercetin, genistein, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof, and methyl hesperidin can suppress inflammation, in particular, in aging tissues within the oral cavity.

The application discloses a method for rapidly detecting 30 compounds in tea, such as catechins, flavonoids, anthocyanins, phenolic acids and amino acids, wherein the 30 compounds are gallic acid, theobromine, GC, protocatechuic acid, theophylline, EGC, theanine, chlorogenic acid, caffeine, catechin, syringic acid, caffeic acid, vanillic acid, epicatechin, EGCG, delphinidin, salicylic acid, GCG, p-coumaric acid, cyanidin, ferulic acid, sinapic acid, rutin, ECG, pelargonidin, myricetin, theaflavin, quercetin, apigenin and kaempferol. The application can realize simultaneous rapid qualitative and quantitative detection of the 30 compounds, and provides technical support for development of active substances in tea.

The present invention relates to a composition for preventing, ameliorating or treating arthritis, comprising a potentilla chinensis extract or apigenin-7-O-glucuronide as an active ingredient. The present invention not only inhibits the expression of MMP-1 and MMP-9, increases the synthesis of type II procollagen, and alleviates inflammation, but also has an effect of preventing, ameliorating or treating arthritis by inhibiting inflammatory pain.