86 results about "Niacinamide" patented technology

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

The invention relates to a whitening and freckle-removing composition containing a composite plant extract and a preparation method of the whitening and freckle-removing composition, and belongs to the technical field of cosmetics. The composition disclosed by the invention is prepared from the following raw materials in parts by weight: 5 to 8 parts of pineapple leaf nano cellulose, 10 to 16 parts of modified starch, 10 to 15 parts of longan seed extract, 6 to 10 parts of mulberry bark extract, 5 to 8 parts of nicotinamide and 8 to 10 parts of hyaluronic acid. The pineapple leaf nanocellulose contains flavonoid and phenolic compounds with double-bond, conjugated double-bond and triple-bond structures, and modified starch is used as a filler to form a film on the surface of skin, so that an anti-ultraviolet protection wall is formed; the betaine-malate ionic liquid is added into the longan seeds, so that extraction of polyphenol in the longan seeds is improved, the longan seeds have acid-base buffering capacity, an auxiliary does not need to be added to adjust the pH value, the components of the prepared composition interact, and the whitening and freckle removing effects are achieved from multiple aspects of ultraviolet resistance, oxidation resistance, inflammation resistance and skin metabolism improvement.

To provide a topical skin preparation that effectively promotes collagen production within the skin, exhibits excellent usability, and effectively enhances post-use stratum corneum moisture content.SOLUTION: A topical skin preparation comprises niacinamide, a heparin-like substance, dipotassium glycyrrhizinate, a collagen peptide, a yeast extract, and glycylglycine. It is preferable that the topical skin preparation further contains hydrogenated soybean phospholipids and phytosterols. It is more preferable that the topical skin preparation has a niacinamide content of 5 mass% or more. It is also preferable that the topical skin preparation further contains at least one plant extract selected from Arnica montana and Plantago major.SELECTED DRAWING: Figure 1

A foaming cleansing composition includes 2.5% to 12.0% Benzoyl Peroxide, at least one acrylate polymer, Hyaluronic Acid, Niacinamide, a combination of anionic and amphoteric surfactants, expressly excluding alkyl polyglucosides, and water. The composition provides a unique textural feel as compared with existing benzoyl peroxide containing products, and in particular, is formulated as a light mousse-type architecture with viscosity which is retained on skin upon application and resists dripping, even in the shower. The composition is shelf stable and stable on application, demonstrating a viscosity of about 18-25 UD (Viscosity Rheomat M3 Spindle), and a pH about 5.5 to about 6.5.

A topical neurocosmetic composition comprising a first component including one or more of bakuchiol, allantoin, squalane, or Morinda citrifolia extract; a second component including one or more of hyaluronic acid, vitamin E, Zanthoxylum alatum fruit extract, Coriandrum sativum seed oil, Vitex agnus-castus extract, Helianthus annuus sprout extract, niacinamide, resveratrol, or an ascorbyl ester; and a cosmetically acceptable oil-in-water vehicle configured to deliver both lipophilic and hydrophilic actives through the skin to dermal neurons. The composition improves measurable skin parameters such as hydration and elasticity and supports psychophysiological comfort. Methods of manufacture and use are also described

The invention relates to the technical field of cosmetics, and particularly discloses an all-directional anti-acne repairing composition as well as a preparation method and application thereof. The comprehensive anti-acne repairing composition is prepared from the following components in parts by weight: 0.01 to 2 parts of flexible salicylic acid, 0.001 to 2 parts of rhodomyrtus tomentosa fruit extract, 0.001 to 0.5 part of quaternary ammonium salt, 0.01 to 5 parts of nicotinamide, 0.001 to 3 parts of herba centellae extract, 0.01 to 3 parts of phellinus linteus extract, 0.0001 to 2 parts of phaeodactylum tricornutum extract and 0.001 to 2 parts of bio-saccharide gum-1. The comprehensive anti-acne repairing composition provided by the invention can resist acnes comprehensively, achieves the effects of removing aged cutin, controlling oil, sterilizing, resisting inflammation, relieving and fading marks and moisturizing, and has a comprehensive repairing effect on various skin injuries including acne skin.

Keratinous Material Care Composition. The present invention relates to a composition, preferably for the care of keratinous materials, comprising: a) at least one extract of Tephrosia purpurea seed; b) niacinamide and / or its derivatives; c) at least one thickener; and d) at least one volatile organic solvent. The present invention also relates to a non-therapeutic process for the care of keratinous materials, comprising the application of the composition according to the present invention to the keratinous materials. Figure for the abstract: none

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

This invention provides a composition for balancing skin sebum secretion, its preparation method, and its application. The composition comprises the following components: Lactobacillus fermentation lysate, yeast / zinc fermentation product, niacinamide, zinc PCA, medicinal spore extract, *Salix friesiensis* extract, capryloyl glycine, Ceylon cinnamon bark extract, and sarcosine. The composition for balancing skin sebum secretion provided by this invention utilizes multiple oil-controlling ingredients to inhibit sebum secretion through multiple pathways, while also possessing certain moisturizing and soothing effects.

This invention provides a magnesium baicalein hydrogel with whitening and anti-skin aging effects and its preparation method. The formulation includes magnesium baicalein, sodium hyaluronate, carbomer, propylene glycol, niacinamide, a pH adjuster, and purified water. The hydrogel uses magnesium baicalein as the main active ingredient, overcoming the traditional deficiency of baicalein's poor water solubility and exhibiting good gel phase stability. The magnesium baicalein in the hydrogel can effectively scavenge free radicals and prevent collagen degradation to combat aging; simultaneously, it inhibits tyrosinase, synergistically achieving a dual whitening effect with niacinamide.

This application provides a barrier-repairing composition and its use. The composition comprises panthenol, niacinamide, folic acid, and cobalamin in a mass ratio of 3-7:1-5:0.0005-0.1:0.00005-0.01. This application also provides uses of the composition and products containing the same. The composition utilizes panthenol, niacinamide, folic acid, and cobalamin in combination, where the components complement and enhance each other, achieving a synergistic effect in upregulating BMAL2 gene expression. This enhances the DNA damage repair capacity of skin fibroblasts and potentially promotes barrier repair. Furthermore, the composition provided herein can significantly reduce the expression of capsaicin receptor 1 (TRPV1) and increase the expression of involucrin, PIEZO1, and TNXB, reducing skin discomfort and enhancing skin barrier function. Furthermore, the composition provided herein can reduce the expression of inflammatory factors, demonstrating its anti-inflammatory effect.

In one aspect, disclosed herein are DNA constructs and biological devices comprising S. cerevisiae cells and extracts and lysates produced therefrom, wherein the DNA constructs encode genes related to NAD+ synthesis and wherein the extracts and lysates produced therefrom include one or more of NAD+, NADP+, NADH, and / or NADPH. Also disclosed are nutritional and pharmaceutical compositions including the extracts and lysates and the coenzymes produced therefrom. In some aspects, the disclosed extracts and lysates can be added to food and beverage products to improve the nutritional profiles of the same.

This invention relates to a method of treating a joint and / or bone disease, slowing progression of a reduction in bone mass, increasing osteoblast formation, decreasing osteoclast formation, and / or reducing osteocyte death, slowing progression of a reduction in joint mobility and / or function, slowing progression of a reduction in cartilage, and / or reducing chondrocyte senescence and / or death by administering a therapeutically effective amount of a SIRT6 activator, optionally with nicotinamide adenine dinucleotide (NAD+) and / or an NAD+ precursor.

The invention discloses a preparation method of a protonated carbon dot photocatalyst for coenzyme regeneration and application of the protonated carbon dot photocatalyst, manganese gluconate and L-aspartic acid are used for synthesizing carbon dots through a hydrothermal method, and then the protonated carbon dots are obtained through an acid leaching method. Photocatalysis coenzyme regeneration relates to transfer and utilization of two electrons and one proton, protonation treatment can affect the band gap structure of the catalyst and the electron and proton transfer problem in the photocatalysis process, and efficient regeneration of reduced nicotinamide adenine dinucleotide (NADH) coenzyme is achieved. The catalyst can be coupled with microorganisms, supports the growth of the microorganisms and converts CO2 into a high value-added product.

The present application belongs to the technical field of coordination chemistry and biomedical science, and provides a multifunctional iridium (III) complex, a preparation method and application thereof. The multifunctional iridium (III) complex (Mito-Ir) is composed of an iridium (III) complex cation and a coordination anion shown in the following formula. Mito-Ir can efficiently target mitochondria, and also has the abilities of phosphorescence imaging, type I and type II active oxygen generation, and photocatalytic oxidation of nicotinamide adenine dinucleotide. Under light irradiation, Mito-Ir triggers severe mitochondrial dysfunction through the above synergistic effect, and then specifically activates the caspase-3 / GSDME signaling pathway, and significantly induces pyroptosis; this pyroptosis-based cell death mechanism can effectively overcome the apoptosis tolerance of tumor cells, and is accompanied by the release of a large amount of inflammatory factors and damage-associated molecular patterns, stimulates immunogenic cell death, and activates the body's anti-tumor immune response.

This invention belongs to the field of skin care technology and discloses an oil-controlling composition, its uses, and skin care products. The oil-controlling composition, by weight, comprises 0.5-1 parts of zinc PCA, 4-9 parts of niacinamide, 0.5-2 parts of pink passionflower extract, and 0.3-0.7 parts of acetyl tetrapeptide-5. The oil-controlling composition of this invention not only inhibits 5α-reductase activity but also promotes autophagy in sebaceous gland cells, thereby enhancing the oil-controlling efficacy of the composition.

A micronutrient composition comprises of several combinations of individual ingredients in forming Mix 11, G12, G13 and core mix formulation. Core mix contains magnesium citrate, alpha-Ketoglutaric acid, L-Citrulline and Taurine. The Mix 11, G12 and G13 contains Magnesium Citrate, Alpha-Ketoglutaric Acid, Niacinamide, L-Glutamine, L-Citrulline, Sodium Pyruvate, Succinic acid, Vitamin B complex, Taurine, L-Cysteine, L-Methionine, L-Ascorbic Acid, Coenzyme Q10 or combination thereof. A method of administering and treating a specific disease which is due to one of an oxidative stress, impaired mitobiogenesis and ATP production in a mammal is disclosed.

The present invention provides a kind of L-threonine aldolase mutant and its application in catalytic synthesis of p-methylsulfonylphenylserine, the L-threonine aldolase mutant source Pseudomonas of the present invention, can use threonine and p-methylsulfonylbenzaldehyde as substrate, with pyridoxal phosphate and reduced nicotinamide adenine dinucleotide as coenzyme, catalysis obtains the synthesis of florfenicol intermediate p-methylsulfonylphenylserine, compared to wild-type L-threonine aldolase, mutant enzyme has higher activity, can effectively improve conversion efficiency, shorten conversion time. The enzyme and technical method reaction conditions of the present invention are mild, pollution is small, and there is good industrial prospect in the production of florfenicol synthetic intermediate.

The application discloses a composition for improving anti-aging and firming effects and a preparation method thereof, and belongs to the technical field of cosmetics. The composition for improving anti-aging and firming effects comprises the following raw materials in parts by mass: galactomyces ferment l filtrate 20-60 parts, nicotinamide adenine dinucleotide 0.1-5 parts, myristyl nicotinate 0.5-5 parts, chrysanthemum coronarium leaf extract 0.2-4.5 parts, lens culinaris seed extract 0.1-5.5 parts and chrysanthemum coronarium extract 0.3-5 parts. The composition for improving anti-aging and firming effects has significant firming and anti-aging effects and is overall mild and non-irritating.

The present invention concerns Amyloid Binding Alcohol Dehydrogenase (ABAD) inhibitors (I) or (II) that interact non-competitively with nicotinamide adenine dinucleotide+H (NADH). Inhibition of ABAD is useful in the treatment or prophylaxis of disease, including Alzheimer's disease (AD) and cancer. Accordingly, the present invention also concerns ABAD inhibitors for use as a medicament, specifically for use in the treatment of Alzheimer's disease and / or cancer.

BENZOYL PEROXIDE FOAMING CLEANSER A foaming cleansing composition includes 2.5% to 12.0% benzoyl peroxide, at least one acrylate polymer, hyaluronic acid, niacinamide, a combination of anionic and amphoteric surfactants, expressly excluding alkyl polyglucosides, and water. The composition offers a unique textural sensation compared to existing benzoyl peroxide products and, in particular, is formulated as a light foam-like architecture with a viscosity that is retained on the skin during application and resists dripping, even in the shower. The composition is ray-stable and application-stable, demonstrating a viscosity of approximately 18-25 UD (Rheomat spindle viscosity M3) and a pH of approximately 5.5 to approximately 6.5. Figure for the abstract: none

HAIR AND / OR SCALP CARE COMPOSITION The present invention relates to a hair and / or scalp care composition comprising: a) at least one extract of Tephrosia purpurea seed; b) niacinamide and / or its derivatives; and c) xanthine and / or its derivatives, wherein the weight ratio of Tephrosia purpurea seed extract to xanthine and / or its derivatives is equal to or less than 4. The present invention also relates to a hair and / or scalp care process comprising applying the composition according to the present invention to the hair and / or scalp. Figure for abstract: none

This invention belongs to the field of cosmetic research technology, specifically relating to a composition containing ultramicrovesicles, its preparation method, and its uses. The composition comprises the following components by weight: 0.01–30.0 parts of animal umbilical cord extract, 0.001–5 parts of a mixture of pro-xylene and azelaic acid, and 0.1–10 parts of niacinamide; the mass ratio of pro-xylene to azelaic acid in the mixture is 2–3:2–3. This invention combines umbilical cord extract ultramicrovesicles, the pro-xylene and azelaic acid mixture, and niacinamide to achieve a synergistic effect, resulting in better and more comprehensive efficacy in three dimensions: anti-wrinkle and firming, whitening and brightening, and soothing and repairing after application to the skin.

1. The name of the product under this design: packaging bottle (collagen peptide niacinamide drink). 2. Purpose of this design product: used for product packaging. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: Design 1 3D drawing. 5. Designate Design 1 as the base design.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.