323 results about "Niacinamide" patented technology

The present invention concerns methods and compositions that can be used, for example, in skin whitening or hyperpigmentation applications. The composition, in non-limiting aspects, can include a vitamin C derivative, niacinamide, an extract formulation comprising cucumber and lemon extract or compounds that include the following formulas:

where R₁, R₂, R₃, R₄, and R₅ are independently an H, an alkyl group, a hydroxyalkyl group, or a carboxyalkyl group

where R₁, R₂, R₃, R₄, and R₅ are independently an H, an alkyl group, a hydroxyalkyl group, or a carboxyalkyl group and where x is an integer from 1 to 30.

Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4-dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9-(2-tetrahydropyranyl)adenine; 1,3-diphenylurea; 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2-furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside-RB1; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside-RG1; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.

Disclosed is a multi-beneficial topical skin care composition, and methods for its use, that can hydrate skin, increase the firmness of skin, reduce the appearance of fine lines or wrinkles on skin, and reduce the appearance of age spots on skin. The composition can include a combination of skin active ingredients comprising euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, a combination of skin moisturizing agents comprising glycerin and butyrospermum parkii, a photo stable combination of sunscreen agents providing the composition with a sun protection factor (SPF) of at least about 15, and a dermatologically acceptable vehicle which imparts a non-greasy feel when applied to skin.

The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain green coffee extract, and optionally vinpocetine, L-camitine, of amylase inhibitor, niacin, Vitamin B3 (niacinamide), vitamin B6 (pyridoxine hydrocholoride), vitamin B12 (cyanocobaolamin), vitamin B5 (pantothenic acid), inositol, phosphorus, iodine, and chromium and/or their dietary and nutraceutically acceptable salts of the same and/or hydrates of the active substance that provide a timed or retarded release formulation of the active substance.

Use of the combination of the tyrosine-arginine dipeptide or derivatives thereof and of niacinamide as a substance P antagonist for treating red blotches on the skin, skin oedema and sensitive skin. Use of this combination for the preparation of a composition for use in treating disorders associated with an excess synthesis and/or release of substance P.

The invention discloses a culture solution for inducing mesenchymal stem cells to differentiate into islet-like cells, and an inducing method and application of the culture solution. The culture solution comprises the following materials: niacinamide, Conophylline, cell growth factor, betacellulin and a base medium. The base medium contains 97% of high glucose DMEM (Dulbecco Modified Eagle Medium), 2% of B-27 and 1% of N-2. The inducing method comprises the following steps of: preparing an inducing culture solution; preparing the human mesenchymal stem cells; taking the human mesenchymal stem cells, inoculating the human mesenchymal stem cells into a six-hole ultralow absorption culture plate by 1.5-2*105cells/hole, adding 3ml inducing culture medium into each hole and carrying out suspended induction; and changing liquid at every 3 days, collecting cell supernatant at the ninth day, and storing the cell supernatant at the temperature of -20 DEG C. The culture solution disclosed by the invention has the advantages that the human mesenchymal stem cells are induced to differentiate into the islet-like cells by utilizing the combination of the niacinamide and the Conophylline, so that the inducing cycle is shortened, the suspension cells are beneficial to being clustered to form cell clusters similar to natural islets, further the induced differentiation efficiency is obviously increased and the clinical application risk is reduced; and the function of inducing the secretion of the cell insulin is obviously improved.

The invention discloses recombinant saccharomyces cerevisiae for producing dammarenediol and protopanoxadiol using xylose and a construction method. The construction method comprises the steps of replacing a promoter of a saccharomyces cerevisiae xylulokinase gene XKS1 with a promoter PFBA1 by virtue of a homologous recombination method, introducing xylose reductase XYL1 and a xylitol dehydrogenase XYL2 expression cassette, increasing the activities of transketolase TKL1 and transaldolase TAL1 so as to obtain recombinant bacteria 1, introducing a farnesyl-diphosphate farnesyltransferase gene ERG9, a squalene monooxygenase gene ERG1 and a dammarenediol synthase gene DS into the recombinant bacteria 1 so as to obtain recombinant bacteria 2, and introducing a nicotinamide adenine dinucleotide-hydroxymethylglutaryl coenzyme A reductase gene NADH-HMGr, farnesyl diphosphatesynthase ERG20 and a protopanoxadiol synthase-cytochrome P450 reductase fusion protein gene PPDS-ATR1 into the recombinant bacteria 2, so as to obtain recombinant bacteria 3. According to the recombinant saccharomyces cerevisiae, dammarenediol and protopanoxadiol can be artificially synthesized by virtue of xylose.

The invention provides a spray water with long-term moisturizing ability and a preparation method thereof. The dosage of each component of the composition is calculated by mass percentage: moisturizing agent, 5%-10%; bio-rich film, 0.1%- 5%; carnosine (β-alanyl-L-histidine), 0.5%-1.0%; asiaticoside, 0.01%-1.0%; yeast extract, 0.05%-10%; nicotinamide (vitamin B3 ), 0.1%-2.0%; rose flower oil, 0.01%-1.0%; plant extract, 1%-10.0%; antibacterial polyol, 0.1-1.0%; purified water, up to 100%; Get; long-lasting moisturizing effect.

The invention discloses a niacinamide ribose phosphate transferase for preparing NMN, a coding gene, a recombinant vector and application and belongs to the technical field of biology. The transferaseis protein of which the amino acid sequence is shown in pSEQ ID No.1 or pSEQ ID No.2 or pSEQ ID No.3 or pSEQ ID No4. The gene for coding the protein is cloned to an expression vector of escherichia coli, and a recombinant plasmid is established; then, the recombinant plasmid is converted into escherichia coli competent cells, a positive clone is selected, an expression strain of recombinant escherichia coli is obtained, and then liquid fermentation is conducted; in the fermentation process, the generated recombinant niacinamide ribose phosphate transferase is generated, and after a substrateis added, beta-nicotinamide mononucleotide can be generated. According to the transferase, NMN is conveniently and efficiently prepared, the fermentation technology is simple, the consumed time is short, the cost is low, the cost of obtaining NMN is 0.25-1.0 yuan/mg, compared with a traditional method, the cost can be lowered by above 90%, the yield reaches 51.75 mg/g of protein, and the economicbenefit is obvious.

Disclosed is a topical skin care composition, and method for its use, that includes 55 to 65% by weight of water, 15 to 20% by weight of a combination of 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (homosalate), 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3 -dione (avobenzone), 2-ethylhexyl 2-hydroxybenzoate (octisalate), and 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate (octocrylene), 3 to 4% by weight of distearlydimonium chloride, and 1 to 3% by weight of a combination of euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, wherein the composition has a sun protection factor of at least 15 or about 15 to 20.

A product and method for moisturizing skin is herein described. The product is a package with associated instructions for applying a niacinamide containing cosmetic composition to skin dispensed from a heating device. The heated cosmetic composition imparts a more rapid moisturization than expected from an identical composition applied at room temperature.

The invention discloses a method for preparing pro-xylane from a biological enzyme by a one-pot method. The method is characterized by comprising the following steps of taking xylose and isopropanol as substrates, generating the pro-xylane under the catalytic action of isopropanol dehydrogenase, pro-xylane synzyme, carbonyl reductase and coenzyme nicotinamide adenine dinucleotide. The method is simple in process, free of chemical reagents, low in cost, high in yield and suitable for industrial production.

The invention discloses whitening and freckle-removing essence. On the basis of reasonably utilizing whitening and freckle-removing components including phenylethyl resorcinol, niacinamide, magnesiumascorbyl phosphate and the like, rosa moschata seed oil, prunus amygdalus dulcis oil and glycyrrhiza glabra root extract are added into the whitening and freckle-removing essence; the three componentsare compounded so that the whitening and freckle-removing effect of a whitening component in the whitening and freckle-removing essence is remarkably improved; when the content of each component in the whitening and freckle-removing essence is optimal, the basic healing rate of freckles reaches 90 percent and the whitening and freckle-removing essence is mild and has no irritation.

The invention provides a whitening composition, whitening skin-brightening cream comprising the same and a preparation method thereof. The whitening skin-brightening cream is prepared from the following components in percent by mass: 0.1-20% of the whitening composition, 1-25% of a wetting agent, 1-5% of an emulsifier, 1-20% of skin-moistening grease, 0.1-5% of a skin conditioner, 0.05-3% of a permeation aid, 0.01-1% of a chelating agent, 0.1-1% of a thickener, 0-1% of essence, 0.05-2% of a preservative and the balance deionized water. The whitening composition is prepared from eight traditional Chinese medicinal material extraction solutions: ginseng, cortex mori radicis, angelica sinensis, glycyrrhiza, tea leaves, ganoderma atrum, rhodiola rosea and folium ginkgo as well as conventionalwhitening agents nicotinamide and tranexamic acid, and has the functions of whitening synergically and reducing irritation. The whitening skin-brightening cream moistens the skin and is not greasy, iseasy to absorb, and is obvious in whitening and skin-brightening effect.

The invention relates to a method for preparing niacinamide nucleoside salt. The method comprises the following steps: replacing ions by niacinamide nucleoside trifluoromethane sulfonate prepared by deacetylation of triacetyl niacinamide nucleoside trifluoromethane in an organic solvent with acids, crystallizing to separate out a crude product, and pulping, thereby obtaining the corresponding niacinamide nucleoside salt. The ion replacement process in the invention overcomes the defects of chemical methods and extraction methods, and is suitable for industrial production.

The invention discloses a beverage for sub-health conditioning and its preparation method. The beverage mainly includes: a Maca extract, a guarana extract, white granulated sugar, malic acid, citric acid, sodium chloride, vitamin B6, niacinamide, inositol, and taurine. Combined use of the components of the beverage disclosed in the invention can achieve a mutually synergistic effect in the aspects of refreshing, consciousness restoring, and fatigue resistance, etc. The beverage has good pressure relieving, vitality boosting, and immune system strengthening effects, improves the sub-health status wholly, balances hormones, improves depression symptoms, enhances human body sexual functions and fertility, and has a good taste, which is sweet and sour and can promote the secretion of saliva or body fluid, thus being suitable for adults to sub-health populations to drink.

The invention discloses formula milk powder to promote children's growth, which comprises various formula components of whole milk powder, skim milk powder, whey protein powder, soybean oil, white granulated sugar, maltodextrin, fructo-oligosaccharide, mineral complex, vitamin complex, and an edible essence, as well as galactooligosaccharide, docosahexaenoic acid, arachidonic acid, milk calcium, choline chloride, niacinamide, Chinese yam extract, Job's tears extract, Chinese date extract, Ampelopsis grossedentata extract, spina date seed extract, and demineralized whey powder. The invention applies to the preparation of children growth formula milk powder; the prepared milk powder is suitable for children 3-15 years hold to eat; a preparation method of the formula milk powder to promote children's growth has mutually cooperated and integral steps, and has the advantages of good process simplicity, good control convenience, low loss of nutrients of the components and the like.

The invention discloses eye-care gel. The eye-care gel is prepared from the following components in percentage by weight: an acrylate copolymer, allantoin, propylene glycol, methyl salicylate, chamomile extract, lutein, peony root and bark extract, semen cassiae extract, green tea extract, hydrolyzed vegetable protein, tocopheryl (vitamin E), niacinamide, menthol crystal, palmitoyl pentapeptide-5,sodium hyaluronate and purified water; the invention further discloses a specific production method of the eye-care gel; the eye-care gel disclosed by the invention can be used for effectively alleviating eye fatigue, eliminating black eye and periocular edema and resisting wrinkles and relaxing, and also has a certain effect on myopia prevention, eyesight health recovery, eye disease control andprevention and the like.

The invention discloses a technique for synthesizing niacinamide and co-producing niacin by hydrolyzing 3-cyanopyridine, comprising the steps of producing niacinamide, producing niacin and the like. The invention has simple technological operation process and little equipment investment and is a niacin and niacinamide co-producing technique, the conversion ratio of 3-cyanopyridine is 100%, the recovery of niacinamide is 90%, and the total recovery of niacin is 99.8%.