54 results about "Niacinamide" patented technology

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

A foaming cleansing composition includes 2.5% to 12.0% Benzoyl Peroxide, at least one acrylate polymer, Hyaluronic Acid, Niacinamide, a combination of anionic and amphoteric surfactants, expressly excluding alkyl polyglucosides, and water. The composition provides a unique textural feel as compared with existing benzoyl peroxide containing products, and in particular, is formulated as a light mousse-type architecture with viscosity which is retained on skin upon application and resists dripping, even in the shower. The composition is shelf stable and stable on application, demonstrating a viscosity of about 18-25 UD (Viscosity Rheomat M3 Spindle), and a pH about 5.5 to about 6.5.

A topical neurocosmetic composition comprising a first component including one or more of bakuchiol, allantoin, squalane, or Morinda citrifolia extract; a second component including one or more of hyaluronic acid, vitamin E, Zanthoxylum alatum fruit extract, Coriandrum sativum seed oil, Vitex agnus-castus extract, Helianthus annuus sprout extract, niacinamide, resveratrol, or an ascorbyl ester; and a cosmetically acceptable oil-in-water vehicle configured to deliver both lipophilic and hydrophilic actives through the skin to dermal neurons. The composition improves measurable skin parameters such as hydration and elasticity and supports psychophysiological comfort. Methods of manufacture and use are also described

Keratinous Material Care Composition. The present invention relates to a composition, preferably for the care of keratinous materials, comprising: a) at least one extract of Tephrosia purpurea seed; b) niacinamide and / or its derivatives; c) at least one thickener; and d) at least one volatile organic solvent. The present invention also relates to a non-therapeutic process for the care of keratinous materials, comprising the application of the composition according to the present invention to the keratinous materials. Figure for the abstract: none

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

This invention provides a magnesium baicalein hydrogel with whitening and anti-skin aging effects and its preparation method. The formulation includes magnesium baicalein, sodium hyaluronate, carbomer, propylene glycol, niacinamide, a pH adjuster, and purified water. The hydrogel uses magnesium baicalein as the main active ingredient, overcoming the traditional deficiency of baicalein's poor water solubility and exhibiting good gel phase stability. The magnesium baicalein in the hydrogel can effectively scavenge free radicals and prevent collagen degradation to combat aging; simultaneously, it inhibits tyrosinase, synergistically achieving a dual whitening effect with niacinamide.

In one aspect, disclosed herein are DNA constructs and biological devices comprising S. cerevisiae cells and extracts and lysates produced therefrom, wherein the DNA constructs encode genes related to NAD+ synthesis and wherein the extracts and lysates produced therefrom include one or more of NAD+, NADP+, NADH, and / or NADPH. Also disclosed are nutritional and pharmaceutical compositions including the extracts and lysates and the coenzymes produced therefrom. In some aspects, the disclosed extracts and lysates can be added to food and beverage products to improve the nutritional profiles of the same.

The invention discloses a preparation method of a protonated carbon dot photocatalyst for coenzyme regeneration and application of the protonated carbon dot photocatalyst, manganese gluconate and L-aspartic acid are used for synthesizing carbon dots through a hydrothermal method, and then the protonated carbon dots are obtained through an acid leaching method. Photocatalysis coenzyme regeneration relates to transfer and utilization of two electrons and one proton, protonation treatment can affect the band gap structure of the catalyst and the electron and proton transfer problem in the photocatalysis process, and efficient regeneration of reduced nicotinamide adenine dinucleotide (NADH) coenzyme is achieved. The catalyst can be coupled with microorganisms, supports the growth of the microorganisms and converts CO2 into a high value-added product.

The present application belongs to the technical field of coordination chemistry and biomedical science, and provides a multifunctional iridium (III) complex, a preparation method and application thereof. The multifunctional iridium (III) complex (Mito-Ir) is composed of an iridium (III) complex cation and a coordination anion shown in the following formula. Mito-Ir can efficiently target mitochondria, and also has the abilities of phosphorescence imaging, type I and type II active oxygen generation, and photocatalytic oxidation of nicotinamide adenine dinucleotide. Under light irradiation, Mito-Ir triggers severe mitochondrial dysfunction through the above synergistic effect, and then specifically activates the caspase-3 / GSDME signaling pathway, and significantly induces pyroptosis; this pyroptosis-based cell death mechanism can effectively overcome the apoptosis tolerance of tumor cells, and is accompanied by the release of a large amount of inflammatory factors and damage-associated molecular patterns, stimulates immunogenic cell death, and activates the body's anti-tumor immune response.

A micronutrient composition comprises of several combinations of individual ingredients in forming Mix 11, G12, G13 and core mix formulation. Core mix contains magnesium citrate, alpha-Ketoglutaric acid, L-Citrulline and Taurine. The Mix 11, G12 and G13 contains Magnesium Citrate, Alpha-Ketoglutaric Acid, Niacinamide, L-Glutamine, L-Citrulline, Sodium Pyruvate, Succinic acid, Vitamin B complex, Taurine, L-Cysteine, L-Methionine, L-Ascorbic Acid, Coenzyme Q10 or combination thereof. A method of administering and treating a specific disease which is due to one of an oxidative stress, impaired mitobiogenesis and ATP production in a mammal is disclosed.

The present invention concerns Amyloid Binding Alcohol Dehydrogenase (ABAD) inhibitors (I) or (II) that interact non-competitively with nicotinamide adenine dinucleotide+H (NADH). Inhibition of ABAD is useful in the treatment or prophylaxis of disease, including Alzheimer's disease (AD) and cancer. Accordingly, the present invention also concerns ABAD inhibitors for use as a medicament, specifically for use in the treatment of Alzheimer's disease and / or cancer.

HAIR AND / OR SCALP CARE COMPOSITION The present invention relates to a hair and / or scalp care composition comprising: a) at least one extract of Tephrosia purpurea seed; b) niacinamide and / or its derivatives; and c) xanthine and / or its derivatives, wherein the weight ratio of Tephrosia purpurea seed extract to xanthine and / or its derivatives is equal to or less than 4. The present invention also relates to a hair and / or scalp care process comprising applying the composition according to the present invention to the hair and / or scalp. Figure for abstract: none

This invention belongs to the field of cosmetic research technology, specifically relating to a composition containing ultramicrovesicles, its preparation method, and its uses. The composition comprises the following components by weight: 0.01–30.0 parts of animal umbilical cord extract, 0.001–5 parts of a mixture of pro-xylene and azelaic acid, and 0.1–10 parts of niacinamide; the mass ratio of pro-xylene to azelaic acid in the mixture is 2–3:2–3. This invention combines umbilical cord extract ultramicrovesicles, the pro-xylene and azelaic acid mixture, and niacinamide to achieve a synergistic effect, resulting in better and more comprehensive efficacy in three dimensions: anti-wrinkle and firming, whitening and brightening, and soothing and repairing after application to the skin.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

The invention relates to the field of astaxanthin synthesis, and discloses recombinant saccharomyces cerevisiae as well as a construction method and application thereof. The recombinant saccharomyces cerevisiae provided by the invention comprises the following exogenous genes: coding genes of beta-carotene hydroxylase CrtZ, beta-carotene ketolase CrtW, nicotinamide adenine dinucleotide kinase, ferredoxin-NADPH (nicotinamide adenine dinucleotide phosphate) oxidoreductase and ferredoxin; on the basis of the gene, other related genes are further introduced to realize that CrtZ and CrtW are positioned in lipid droplets by lipid droplet targeting peptide Olesion, so that the yield of astaxanthin is increased, finally geranyl-geranyl diphosphate synthase, phytoene dehydrogenase and phytoene synthase are targeted to endoplasmic reticulum through endoplasmic reticulum targeting peptide, and the yield of astaxanthin is increased. Therefore, the yield of the fermentation tank is up to 440mg / L. The recombinant saccharomyces cerevisiae provided by the invention is clear in genetic background, can stably and efficiently produce astaxanthin, and has a wide application prospect.

CLEANSING AND / OR CARE COMPOSITION FOR KERATINOUS MATERIALS The present invention relates to a cleansing and / or care composition for keratinous materials, comprising: a) at least one extract of Tephrosia purpurea seed; b) at least one anionic sulfate-type surfactant; and c) niacinamide and / or one of its derivatives. The present invention also relates to a non-therapeutic process for cleansing and / or caring for keratinous materials, comprising applying the composition according to the present invention to the keratinous materials. Figure for the abstract: none

The present invention relates to a use of nicotinamide adenine dinucleotide (NAD) for preventing or treating olfactory disorders. The NAD increases the thickness of olfactory epithelial tissue and promotes the proliferation of olfactory stem cells and the differentiation thereof into olfactory neurons, and thus can effectively restore lost olfactory sense. Therefore, the NAD can be effectively used for preventing, ameliorating or treating olfactory disorders.

The invention belongs to the technical field of medicines, and particularly relates to a prodrug for supplementing NAD < + >, which is an NAMPT agonist YB8, and an application of the prodrug in prevention and treatment of abdominal aortic aneurysm. The invention discloses a prodrug YB8 capable of specifically activating nicotinamide phosphoribosyltransferase (NAMPT), and the prodrug YB8 can effectively improve the level of NAD + (nicotinamide adenine dinucleotide) in cells, so that the degenerative change of a vascular structure is slowed down, the purposes of protecting blood vessels and treating abdominal aortic aneurysm are achieved, and the YB8 is proved to be used as a specific activator of NAMPT for the first time. The multi-target treatment effect is achieved by improving the blood vessel NAD + level; the discovery provides a brand new strategy for the drug treatment of abdominal aortic aneurysm, and the treatment advantages are as follows: ultrasonic imaging proves that the tumor progress can be obviously inhibited; the discovery lays an important foundation for developing clinical treatment of abdominal aortic aneurysm based on NAD + metabolism regulation.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

The present invention addresses the problem of providing: a composition that increases the amount of intracellular ATP and the amount of intracellular NAD; and a composition that improves motor performance. More specifically, the present invention provides a composition for increasing the amounts of intracellular adenosine triphosphate (ATP) and intracellular nicotinamide adenine dinucleotide (NAD), the composition being obtained by combining (a) and (b): (a) an NAD precursor or a pharmaceutically acceptable salt thereof; and (b) one or more substances selected from the group consisting of uridine and uridine precursors, or one or more pharmaceutically acceptable salts thereof, and / or one or more substances selected from the group consisting of inosine and inosine precursors, or one or more pharmaceutically acceptable salts thereof.　Furthermore, the present invention provides a composition for enhancing muscle strength, the composition being characterized by inclluding a combination of (c) and (d): (c) one or more substances selected from the group consisting of β-alanine and β-alanine precursors, or one or more pharmaceutically acceptable salts thereof; and (d) one or more substances selected from the group consisting of uridine and uridine precursors, or one or more pharmaceutically acceptable salts thereof, and / or one or more substances selected from the group consisting of inosine and inosine precursors, or one or more pharmaceutically acceptable salts thereof.

In some aspects, the disclosure relates to a composition including niacinamide and polypodium leucotomos extract, optionally with additional photoprotective ingredients including ascorbic acid, optionally biotin, astaxanthin, bovine collagen peptides, L-glutathione, hyaluronic acid, and inositol. The composition provides rapid and measurable photoprotection, reducing UV-induced erythema by approximately 60-68% when administered 1-2 hours prior to UV exposure. Clinical studies demonstrate significant increases in minimal erythema dose (MED) with effects persisting for at least 24 hours following a single oral administration. The composition exhibits excellent formulation characteristics including superior mixability, clarity, and palatability when formulated as a beverage powder.

Disclosed is a multi-functional nanoparticle delivery system comprising a biodegradable core of poly(lactic-co-glycolic acid) (PLGA) or calcium phosphate (CaP), encapsulating a nicotinamide adenine dinucleotide (NAD+) precursor and a sirtuin activator. Surrounding the core is a liposomal or polymeric layer containing one or more senolytic agents, and an outer layer of magnetic iron oxide nanoparticles for targeted delivery, external manipulation, and imaging. In some embodiments, the nanoparticle surface is functionalized for conjugation with autologous mesenchymal stem cells to enhance homing and regenerative potential. The system is pH-responsive, releasing its payload in acidic microenvironments typical of senescent or diseased cells, while remaining stable at physiological pH. This integrated design supports NAD+ restoration, sirtuin activation, senescent cell clearance, and tissue regeneration. Applications include treatment of age-related diseases, regenerative medicine, cardiovascular and neurodegenerative disorders, and cosmetic skin rejuvenation.

The application relates to the cosmetic technical field, and particularly discloses a multi-channel whitening and freckle-removing compound and a preparation method thereof. In the multi-channel whitening and freckle-removing compound, the preparation raw materials comprise emollients, moisturizers, skin protectants A, antioxidants, skin protectants B, skin protectants C, a whitening composition, a composite extract and a solvent; the whitening composition comprises niacinamide; the skin protectants C comprise a phenylethyl resorcinol inclusion compound; and the composite extract comprises grape fruit cell extract and cornus officinalis extract. The multi-channel whitening and freckle-removing compound is prepared by compounding multiple functional components, synergistically acts from multiple mechanisms such as inhibiting melanin synthesis, blocking melanin transport, antioxidation and repairing skin barrier, and can realize the high-efficiency whitening and freckle-removing effect while guaranteeing the skin safety.

The invention discloses a preparation method of a sulfo-amino acid compound. The sulfo-amino acid compound is a compound as shown in a formula I, the method comprises the following steps: in the presence of a buffer solution, an ammonia source, nicotinamide adenine dinucleotide and formate dehydrogenase, catalyzing a thiomethyl alpha-butanone acid compound as shown in a formula II to perform asymmetric reductive amination reaction by using alpha-amino acid dehydrogenase containing an amino acid sequence as shown in SEQ ID NO: 1 or a mutant thereof, so as to generate the compound as shown in the formula I, . According to the method, based on specific catalysis of an alpha-amino acid dehydrogenase mutant obtained through directed evolution on thiomethyl alpha-butanone acid, efficient and high-stereoselectivity asymmetric reductive amination synthesis of corresponding thioamino acid is achieved.

A composition, preferably for cleansing and / or caring for keratin materials, comprising:a) at least one cationic surfactant;b) at least one fatty compound chosen from C12-C22 fatty alcohols and C12-C22 fatty acids;c) at least one tephrosia purpurea seed extract; and d) niacinamide and / or derivatives thereof.A non-therapeutic process for cleansing and / or caring for keratin materials comprising applying the composition onto the keratin materials.