156 results about "Niacinamide" patented technology

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

The invention discloses a scalp essence capable of controlling oil and removing dandruff and a preparation method thereof, and provides the scalp essence capable of controlling oil and removing dandruff. The formula consists of the following raw materials: water, saccharomycetes / rice fermentation product filtrate, butanediol, phenoxyethanol, caprylic acid / capric triglyceride, galactose yeast-like bacterium fermentation product filtrate, allantoin, a saccharomycetes / zinc fermentation product, nicotinamide, arginine, polysorbate-20, hydrogenated lecithin, acrylic acid (ester) / C10-30 and an alkanol acrylate cross-linked polymer. Hydrolyzed sodium hyaluronate and trace components. According to the oil-controlling and dandruff-removing scalp essence disclosed by the invention, through the synergistic interaction among the raw materials, the effects of replenishing water, preserving moisture, controlling oil and removing dandruff are increased, the effects of relieving, recovering oil-water balance, recovering skin elasticity and delaying senescence are also achieved, the effects of preventing hair loss and nourishing hair are also achieved, and meanwhile, the oil-controlling and dandruff-removing scalp essence has the advantage of being stable in storage.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

The invention relates to a whitening and freckle-removing composition containing a composite plant extract and a preparation method of the whitening and freckle-removing composition, and belongs to the technical field of cosmetics. The composition disclosed by the invention is prepared from the following raw materials in parts by weight: 5 to 8 parts of pineapple leaf nano cellulose, 10 to 16 parts of modified starch, 10 to 15 parts of longan seed extract, 6 to 10 parts of mulberry bark extract, 5 to 8 parts of nicotinamide and 8 to 10 parts of hyaluronic acid. The pineapple leaf nanocellulose contains flavonoid and phenolic compounds with double-bond, conjugated double-bond and triple-bond structures, and modified starch is used as a filler to form a film on the surface of skin, so that an anti-ultraviolet protection wall is formed; the betaine-malate ionic liquid is added into the longan seeds, so that extraction of polyphenol in the longan seeds is improved, the longan seeds have acid-base buffering capacity, an auxiliary does not need to be added to adjust the pH value, the components of the prepared composition interact, and the whitening and freckle removing effects are achieved from multiple aspects of ultraviolet resistance, oxidation resistance, inflammation resistance and skin metabolism improvement.

To provide a topical skin preparation that effectively promotes collagen production within the skin, exhibits excellent usability, and effectively enhances post-use stratum corneum moisture content.SOLUTION: A topical skin preparation comprises niacinamide, a heparin-like substance, dipotassium glycyrrhizinate, a collagen peptide, a yeast extract, and glycylglycine. It is preferable that the topical skin preparation further contains hydrogenated soybean phospholipids and phytosterols. It is more preferable that the topical skin preparation has a niacinamide content of 5 mass% or more. It is also preferable that the topical skin preparation further contains at least one plant extract selected from Arnica montana and Plantago major.SELECTED DRAWING: Figure 1

The present invention relates to a composition, preferably cosmetic, comprising: - at least one thiopyridinone compound chosen from the compounds of formula (I), the tautomers of formula (I') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof: - at least niacinamide or one of its derivatives; - at least gluconolactone; - a surfactant system comprising (i) at least one N-acyl-amino surfactant and (ii) at least one amphoteric surfactant; and - at least one non-associative crosslinked copolymer of acrylic acid and / or methacrylic acid, or one of their esters.

Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.

The invention discloses an immunomodulatory preparation based on stem cell exosome and a preparation method and application thereof, and relates to the technical field of biological medicine. The preparation is prepared from an exosome, a freeze-drying protective agent, dipotassium glycyrrhizinate and nicotinamide, and the exosome contains miR-146a, miR-17-5p and TGF-beta and is used for inhibiting release of proinflammatory factors. The preparation method comprises the following steps: step 1, cell culture; step 2, ultrafiltration purification; step 3, preparing a freeze-drying protective agent; step 4, preparing freeze-dried powder; and step 5, mixing. The preparation can be used for preparing a composition for treating autoimmune diseases. According to the preparation method disclosed by the invention, an ultrafiltration and freeze-drying combined process is adopted, so that the extraction cost is greatly reduced, and the single-time treatment capacity is increased; the preparation disclosed by the invention has the effects of resisting inflammation, promoting repair and regulating immune balance, and breaks through the limitation of a single target spot; the preparation is free of animal source components, low in immunogenicity and high in clinical tolerance.

A foaming cleansing composition includes 2.5% to 12.0% Benzoyl Peroxide, at least one acrylate polymer, Hyaluronic Acid, Niacinamide, a combination of anionic and amphoteric surfactants, expressly excluding alkyl polyglucosides, and water. The composition provides a unique textural feel as compared with existing benzoyl peroxide containing products, and in particular, is formulated as a light mousse-type architecture with viscosity which is retained on skin upon application and resists dripping, even in the shower. The composition is shelf stable and stable on application, demonstrating a viscosity of about 18-25 UD (Viscosity Rheomat M3 Spindle), and a pH about 5.5 to about 6.5.

The present invention relates to an anti-allergy, whitening and freckle-removing composition and a preparation method thereof. The anti-allergy, whitening and freckle-removing composition is composed of the following components in mass fractions: 0.5-2% of Kalanchoe extract, 0.5-2% of Cornus controversa Hance extract, 0.5-2% of Yucca filamentosa extract, 0.5-2% of Chrysanthemum cinerariifolium extract, 1-3% of VC ethyl ether, 0.5-5% of arbutin, 0.1-2% of 4-butylresorcinol, 1-10% of niacinamide, 3-15% of humectant, 3-15% of emollient, 0.5-2% of penetrant, and the balance being water. The anti-allergy, whitening and freckle-removing composition is added with Kalanchoe extract, Cornus controversa Hance extract, Yucca filamentosa extract and Chrysanthemum cinerariifolium extract. Through the synergistic effect of the four extracts, the anti-allergy, whitening and freckle-removing composition has little irritation while maintaining excellent whitening and freckle-removing effects.

A topical neurocosmetic composition comprising a first component including one or more of bakuchiol, allantoin, squalane, or Morinda citrifolia extract; a second component including one or more of hyaluronic acid, vitamin E, Zanthoxylum alatum fruit extract, Coriandrum sativum seed oil, Vitex agnus-castus extract, Helianthus annuus sprout extract, niacinamide, resveratrol, or an ascorbyl ester; and a cosmetically acceptable oil-in-water vehicle configured to deliver both lipophilic and hydrophilic actives through the skin to dermal neurons. The composition improves measurable skin parameters such as hydration and elasticity and supports psychophysiological comfort. Methods of manufacture and use are also described

The present invention belongs to the field of cosmetics and discloses a composition, which includes prickly ash fruit extract, epigallocatechin gallate, diacetylboldine, sanguisorba root extract, and niacinamide. The composition has excellent antioxidant efficacy as detected by the DPPH method. At the same time, the present invention also discloses a composition for resisting heat stimulation and UV stimulation. By using a nematode model for detection, it can significantly inhibit the level of lipofuscin generation in nematodes after heat stimulation and ultraviolet light stimulation, and there is a significant synergistic effect on the inhibition of lipofuscin generation in nematodes after heat stimulation and ultraviolet light stimulation when the composition is used in combination with withania somnifera root extract. It shows that the composition of the present invention has very good anti-wrinkle effects of anti-photoaging and anti-thermal aging, and can effectively prevent the formation of skin spots.

The invention relates to the technical field of cosmetics, and particularly discloses an all-directional anti-acne repairing composition as well as a preparation method and application thereof. The comprehensive anti-acne repairing composition is prepared from the following components in parts by weight: 0.01 to 2 parts of flexible salicylic acid, 0.001 to 2 parts of rhodomyrtus tomentosa fruit extract, 0.001 to 0.5 part of quaternary ammonium salt, 0.01 to 5 parts of nicotinamide, 0.001 to 3 parts of herba centellae extract, 0.01 to 3 parts of phellinus linteus extract, 0.0001 to 2 parts of phaeodactylum tricornutum extract and 0.001 to 2 parts of bio-saccharide gum-1. The comprehensive anti-acne repairing composition provided by the invention can resist acnes comprehensively, achieves the effects of removing aged cutin, controlling oil, sterilizing, resisting inflammation, relieving and fading marks and moisturizing, and has a comprehensive repairing effect on various skin injuries including acne skin.

Keratinous Material Care Composition. The present invention relates to a composition, preferably for the care of keratinous materials, comprising: a) at least one extract of Tephrosia purpurea seed; b) niacinamide and / or its derivatives; c) at least one thickener; and d) at least one volatile organic solvent. The present invention also relates to a non-therapeutic process for the care of keratinous materials, comprising the application of the composition according to the present invention to the keratinous materials. Figure for the abstract: none

A method, preferably a cosmetic and / or non-therapeutic method - of re-balancing a ceramide profile of a ceramide-containing tissue; or - of maintaining a ceramide profile of a ceramide-containing tissue; or - of preventing or treating a disruption of a ceramide profile of a ceramide-containing tissue, wherein the method comprises a step of application of niacinamide to such ceramide-containing tissue.

This invention provides a composition for balancing skin sebum secretion, its preparation method, and its application. The composition comprises the following components: Lactobacillus fermentation lysate, yeast / zinc fermentation product, niacinamide, zinc PCA, medicinal spore extract, *Salix friesiensis* extract, capryloyl glycine, Ceylon cinnamon bark extract, and sarcosine. The composition for balancing skin sebum secretion provided by this invention utilizes multiple oil-controlling ingredients to inhibit sebum secretion through multiple pathways, while also possessing certain moisturizing and soothing effects.

This invention provides a magnesium baicalein hydrogel with whitening and anti-skin aging effects and its preparation method. The formulation includes magnesium baicalein, sodium hyaluronate, carbomer, propylene glycol, niacinamide, a pH adjuster, and purified water. The hydrogel uses magnesium baicalein as the main active ingredient, overcoming the traditional deficiency of baicalein's poor water solubility and exhibiting good gel phase stability. The magnesium baicalein in the hydrogel can effectively scavenge free radicals and prevent collagen degradation to combat aging; simultaneously, it inhibits tyrosinase, synergistically achieving a dual whitening effect with niacinamide.

This application provides a barrier-repairing composition and its use. The composition comprises panthenol, niacinamide, folic acid, and cobalamin in a mass ratio of 3-7:1-5:0.0005-0.1:0.00005-0.01. This application also provides uses of the composition and products containing the same. The composition utilizes panthenol, niacinamide, folic acid, and cobalamin in combination, where the components complement and enhance each other, achieving a synergistic effect in upregulating BMAL2 gene expression. This enhances the DNA damage repair capacity of skin fibroblasts and potentially promotes barrier repair. Furthermore, the composition provided herein can significantly reduce the expression of capsaicin receptor 1 (TRPV1) and increase the expression of involucrin, PIEZO1, and TNXB, reducing skin discomfort and enhancing skin barrier function. Furthermore, the composition provided herein can reduce the expression of inflammatory factors, demonstrating its anti-inflammatory effect.

In one aspect, disclosed herein are DNA constructs and biological devices comprising S. cerevisiae cells and extracts and lysates produced therefrom, wherein the DNA constructs encode genes related to NAD+ synthesis and wherein the extracts and lysates produced therefrom include one or more of NAD+, NADP+, NADH, and / or NADPH. Also disclosed are nutritional and pharmaceutical compositions including the extracts and lysates and the coenzymes produced therefrom. In some aspects, the disclosed extracts and lysates can be added to food and beverage products to improve the nutritional profiles of the same.

This invention relates to a method of treating a joint and / or bone disease, slowing progression of a reduction in bone mass, increasing osteoblast formation, decreasing osteoclast formation, and / or reducing osteocyte death, slowing progression of a reduction in joint mobility and / or function, slowing progression of a reduction in cartilage, and / or reducing chondrocyte senescence and / or death by administering a therapeutically effective amount of a SIRT6 activator, optionally with nicotinamide adenine dinucleotide (NAD+) and / or an NAD+ precursor.

The invention discloses a preparation method of a protonated carbon dot photocatalyst for coenzyme regeneration and application of the protonated carbon dot photocatalyst, manganese gluconate and L-aspartic acid are used for synthesizing carbon dots through a hydrothermal method, and then the protonated carbon dots are obtained through an acid leaching method. Photocatalysis coenzyme regeneration relates to transfer and utilization of two electrons and one proton, protonation treatment can affect the band gap structure of the catalyst and the electron and proton transfer problem in the photocatalysis process, and efficient regeneration of reduced nicotinamide adenine dinucleotide (NADH) coenzyme is achieved. The catalyst can be coupled with microorganisms, supports the growth of the microorganisms and converts CO2 into a high value-added product.

The present invention discloses an intraocular irrigation solution containing niacinamide. Niacinamide serves as an active substance in the intraocular irrigation solution, which has the effects of improving the function of corneal endothelial cells, inhibiting cell apoptosis and cell fusion, and improving the mitochondrial damage condition, thereby alleviating or inhibiting corneal edema, reduction of corneal endothelial cells, abnormal corneal transparency, abnormal corneal thickness, abnormal corneal endothelial cell density, abnormal corneal endothelial cell morphology, and abnormal expression of corneal endothelial cell functional proteins caused by ultrasonic stimulation, heat stimulation or oxidative damage to corneal endothelial cells during phacoemulsification surgery.

The present application belongs to the technical field of coordination chemistry and biomedical science, and provides a multifunctional iridium (III) complex, a preparation method and application thereof. The multifunctional iridium (III) complex (Mito-Ir) is composed of an iridium (III) complex cation and a coordination anion shown in the following formula. Mito-Ir can efficiently target mitochondria, and also has the abilities of phosphorescence imaging, type I and type II active oxygen generation, and photocatalytic oxidation of nicotinamide adenine dinucleotide. Under light irradiation, Mito-Ir triggers severe mitochondrial dysfunction through the above synergistic effect, and then specifically activates the caspase-3 / GSDME signaling pathway, and significantly induces pyroptosis; this pyroptosis-based cell death mechanism can effectively overcome the apoptosis tolerance of tumor cells, and is accompanied by the release of a large amount of inflammatory factors and damage-associated molecular patterns, stimulates immunogenic cell death, and activates the body's anti-tumor immune response.

This invention belongs to the field of skin care technology and discloses an oil-controlling composition, its uses, and skin care products. The oil-controlling composition, by weight, comprises 0.5-1 parts of zinc PCA, 4-9 parts of niacinamide, 0.5-2 parts of pink passionflower extract, and 0.3-0.7 parts of acetyl tetrapeptide-5. The oil-controlling composition of this invention not only inhibits 5α-reductase activity but also promotes autophagy in sebaceous gland cells, thereby enhancing the oil-controlling efficacy of the composition.

This application relates to the technical field of cosmetics, and specifically discloses a skin care composition, a pearl-shaped essence and a preparation method thereof. The skin care composition of this application comprises the following components by mass percentage: aqueous phase: 2-5% of plant extract I, 1-11% of humectant, 1-3% of niacinamide and 0.5-1% of thickener; the plant extract I is kangaroo paw extract, gleditsia horrida seed extract, roselle extract and hydrolyzed ginsenoside; oil phase: 0.5-2% of plant extract II, 0.5-1.5% of emollient and 0.1-0.3% of antioxidant; the plant extract II is jojoba seed oil and dunaliella salina extract; water. The skin care composition provided by this application can be used to prepare a pearl-shaped essence with independent oil beads, which can achieve efficient penetration and deep moisturization of the skin while maintaining excellent dispersibility and stability, and achieve a good repair effect.

The present invention provides an enhanced whitening cosmetic composition comprising (A) concentrated birch sap and (B) one or more substances selected from arbutin, tranexamic acid, niacinamide, glabridin, ascorbic acid, ascorbyl glucoside, ascorbyl dipalmitate and ascorbyl tetraisopalmitate, wherein the concentrated birch sap is concentrated at a multiple of about 1.05-6 times, preferably about 1.1-5 times, and more preferably about 1.2-4 times.