26 results about "Benzyl benzoate" patented technology

A bremelanotide pharmaceutical composition, a formulation thereof, a preparation method therefor, and use thereof. The bremelanotide pharmaceutical composition comprises bremelanotide as a pharmaceutically active ingredient, a solvent, and a polymer. The solvent includes one or more of N-methylpyrrolidone, polyethylene glycol, dimethyl sulfoxide, and benzyl benzoate and enables the plasma concentration of bremelanotide to be stably greater than 0.1 ng / mL at 120-168 h, thereby achieving the target sustained release. The bremelanotide pharmaceutical composition can be directly injected and does not require the addition of a thickener, a gel-forming agent, or other excipients.

The present invention provides novel compositions for treating malarial infections comprising prodrugs of ELQ-300 and an oil, wherein the composition can further comprise benzyl alcohol and / or benzyl benzoate, and methods of use thereof.

Kosmetische Zubereitung enthaltend 4-Hydroxy-3-methoxybenzaldehyd (INCI: Vanillin), 2,4-Bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin (INCI: Bis- Ethylhexyloxyphenol methoxyphenyl Triazine), Dipropylenglycoldibenzoat (INCI: Dipropylene Glycol Dibenzoate) und Benzylbenzoat (INCI: Benzyl Benzoate).

The invention belongs to the technical field of plant genetic engineering, and discloses a coding gene of benzyl benzoate 2-hydroxylase participating in a rice PAL-dependent salicylic acid synthesis pathway and application of the coding gene, and the nucleotide sequence of OSD3 is SEQ ID NO: 1; the nucleotide sequence of a coding protein region is SEQ ID NO: 2; the amino acid sequence of the coded protein is SEQ ID NO: 3; according to the invention, an OSD3 gene is knocked out through CRISPR / Cas9 under the background of Zhonghua 11, a mutant osd3 of which the SA of a rice leaf is reduced to 20% of that of a wild type is obtained, and an OSD3 overexpression plant is created by constructing an OSD3-pMDC43 overexpression vector.

The invention belongs to the technical field of plant genetic engineering, and discloses a gene for regulating and controlling the endogenous salicylic acid content and disease resistance of rice by using an SA synthetic gene OSD3 participating in rice PAL dependence and application of the gene, and the nucleotide sequence of the OSD3 is SEQ ID NO: 1; the nucleotide sequence of a coding protein region is SEQ ID NO: 2; the amino acid sequence of the coded protein is SEQ ID NO: 3; according to the invention, an OSD3 gene is knocked out through CRISPR / Cas9 under the background of Zhonghua 11, a mutant osd3 of which the SA of a rice leaf is reduced to 20% of that of a wild type is obtained, and an OSD3 overexpression plant is created by constructing an OSD3-pMDC43 overexpression vector.

An injectable pharmaceutical composition comprising a solution of 3-acyl-buprenorphine or a pharmaceutical salt thereof in a biocompatible organic solvent, wherein the injectable pharmaceutical composition exhibits a sustained release profile lasting for more than one week when injected into a patient. The acyl group is an alkylcarbonyl group and an alkyl portion of the alkylcarbonyl group is straight chain, branched chain, having 1-20 carbon atoms. The biocompatible organic solvent is N-methyl-2-pyrrolidone, ethyl acetate, ethanol, butanol, 2-butanol, isobutanol, isopropanol, glycerin, benzyl benzoate, dimethyl sulfoxide, N,N-dimethylacetamide, propylene glycol, dimethyl glycol, benzyl alcohol, or a combination of two or more thereof.

This invention discloses the application of benzyl benzoate in the preparation of repellents for red imported fire ants. Experiments verified that after treatment with benzyl benzoate at a concentration of 1 μL / mL or higher for 0.5 h, the feeding and repellency rate of red imported fire ant workers reached 92.74%. After 12 h of treatment, benzyl benzoate at a concentration of 10 μL / mL or higher still maintained a good repellent effect, indicating that benzyl benzoate has a long-lasting repellent activity against red imported fire ants. After treatment with benzyl benzoate at a concentration of 50 μL / mL or higher for 24 h, the burrowing behavior of red imported fire ant workers was significantly reduced. Benzyl benzoate at a concentration of 10 μL / mL or higher showed good repellent effects against red imported fire ants and can be used in future red imported fire ant protective agents; benzyl benzoate at a concentration of 50 μL / mL or higher can be used in red imported fire ant soil repellents.

This invention relates to the field of progesterone preparation technology, specifically to a progesterone lipid liquid crystal suitable for injection, its preparation method, and the pharmaceutical uses of the product. The progesterone lipid liquid crystal injection provided by this invention is a lipid liquid crystal system formed by mixing an oil phase and an aqueous phase. The oil phase includes progesterone, benzyl benzoate, phospholipids, vitamin E, and oleic acid, while the aqueous phase includes water for injection. This invention optimizes the mass ratio of phospholipids to oleic acid in the oil phase to 10:1, and the mass ratio of progesterone, benzyl benzoate, and vitamin E to 2:6:(5-3), resulting in a stable lipid liquid crystal system that improves injection compliance, reduces fat deposition, and achieves sustained drug efficacy for more than 12 hours.

The utility model relates to the technical field of sewage treatment, in particular to a benzyl benzoate static crystallization and purification device which comprises a container, the container is provided with a feed port and a discharge port, and at least three heat exchange pipelines are arranged in the container; the heat exchange pipeline comprises an inner pipe and an outer pipe, the outer pipe sleeves the outer side of the inner pipe, and the inner pipe and the outer pipe are coaxial; the outer wall of the inner pipe is thinner than the inner wall of the outer pipe, so that a gap is formed between the inner pipe and the outer pipe, the two ends of the gap are sealed, and water is contained in the gap; an inlet and an outlet of the inner pipe extend out of the container; an outlet of the inner pipe is communicated with the liquid storage tank; the device further comprises a switching valve. An outlet of the switching valve is connected to a liquid supply pipeline; the liquid supply pipeline is connected to at least three liquid supply branch pipes; the at least three liquid supply branch pipes are respectively communicated with inlets of inner pipes of the at least three heat exchange pipelines; two liquid inlets of the switching valve are respectively communicated with a cold liquid supply pipeline and a hot liquid supply pipeline; benzyl benzoate crystallization is more uniform, and purity and yield of benzyl benzoate crystallization purification are improved.

The invention discloses a progesterone long-acting slow-release injection as well as a preparation method and medical application thereof. The progesterone long-acting slow-release injection comprises a therapeutically effective amount of progesterone, a pharmaceutically acceptable ester organic solvent; the solvent is selected from the combination of glyceryl triacetate and benzyl benzoate. The progesterone long-acting slow-release injection provided by the invention can form a drug reservoir in situ after injection, realizes long-term slow release of progesterone, remarkably reduces the initial burst release effect, and can be used for treating or preventing luteal insufficiency or luteal support in assisted reproduction. In addition, the progesterone long-acting slow-release injection is simple in preparation process, all the components can be dissolved and mixed at the room temperature, and large-scale production is easy to achieve.

The application provides a dibenzyl ether oxidation process, which utilizes oxygen to react with dibenzyl ether, compared with the traditional oxidation process using nitric acid or air as an oxidant, tail gas generation and treatment are avoided, VOC emission in the tail gas is avoided, and environmental pollution is reduced; the dibenzyl ether oxidation process can obtain benzaldehyde and benzyl benzoate simultaneously by using the by-product dibenzyl ether in industry, the process is simple, and economic benefits are high; the reactor of the dibenzyl ether oxidation process is a micro-channel reactor, by controlling the reaction temperature in the reactor to be 160-180 DEG C, the reaction pressure to be 1.5-2.5 Mpa, and the reaction time to be 5-10 min, oxygen and dibenzyl ether can be fully contacted and mixed, the oxidation rate is greatly improved, meanwhile, the residence time of the material in the reactor is short, the volume and liquid holding capacity of the reactor are relatively small, so that the investment cost and danger of the process are small.

Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

The application relates to the technical field of PET geothermal film, and discloses a high-temperature-resistant geothermal film and a preparation method thereof. Polyethylene terephthalate, carboxyl polyetherimide and modified graphene are blended, extruded and blow molded to obtain the high-temperature-resistant geothermal film. The carboxyl polyetherimide contains benzyl benzoate structural units similar to PET, and the two form an alloy-like system with good compatibility. The modified graphene has good dispersibility and excellent compatibility with PET, and contains more carboxyl groups, which form hydrogen bonds and other interactions with the carboxyl groups in the side chains of the carboxyl polyetherimide, so that the graphene can be uniformly dispersed in the composite system of PET and the carboxyl polyetherimide, and better reinforcing effect is achieved, and the tensile strength and elongation at break of the PET composite geothermal film are significantly improved. The geothermal film has high retention rates of the tensile strength and the elongation at break after high-temperature thermal aging, and has good high-temperature resistance.

The invention provides functional aromatherapy essential oil and a preparation device thereof, the functional aromatherapy essential oil comprises a neurotransmitter regulation and control group, a meridian stimulation group and a biological rhythm regulation group, the neurotransmitter regulation and control group comprises 5-15 parts of lavender essential oil and 3-10 parts of Roman chamomile essential oil; according to the invention, a composite system of a neurotransmitter regulation group, a meridian stimulation group and a biological rhythm regulation group is adopted, and all the components form a multi-target synergistic effect through a specific ratio; according to the supercritical CO2 extraction technology of ligusticum wallichii, it is ensured that the ligustilide content is larger than or equal to 8%; the evening primrose seed oil is encapsulated by a beta-cyclodextrin embedding technology, so that gamma-linolenic acid is effectively prevented from being oxidized, and the shelf life of the product is prolonged; according to the formula, transmission of neurotransmitters is regulated and controlled through linalyl acetate and alpha-bisabolol, meridian circulation is stimulated by means of d-limonene, the secretion period of human melatonin is synchronized through benzyl benzoate, three-dimensional adjustment of nerves, meridians and rhythms is achieved, and the limitation of traditional single-target action is broken through.

The invention provides a progesterone slow-release oily injection. The progesterone slow-release oily injection comprises 6-30 wt% of progesterone; 5-80 wt% of an organic solvent; and, optionally, 10 to 70 wt% of oil for injection; the organic solvent comprises at least one of benzyl benzoate or benzyl alcohol. The injection provided by the invention can be used for treating threatened abortion, assisting reproduction or regulating and controlling the reproduction cycle, and has the characteristics of long-acting slow release, low injection frequency, good safety, simple preparation method, easiness in expanded production and the like.

Long term storage stable fulvestrant-containing compositions are disclosed. The compositions can include fulvestrant; a solvent selected from dimethyl sulfoxide (DMSO), glycofurol, N-methyl pyrrolidone, and mixtures thereof; an oil mixture selected from a mixture of caprylic and capric triglycerides, a mixture of caprylic, capric and linoleic triglycerides, a mixture of caprylic, capric and succinic triglycerides, and a mixture of propylene glycol dicaprylate and propylene glycol dicaprate; and a sustained release member selected from benzyl benzoate, dihydrolipoic acid, benzyl alcohol and lipoic acid. The fulvestrant-containing compositions have less than about 5% total impurities, on a normalized peak area response (“PAR”) basis as determined by high performance liquid chromatography (“HPLC”) at a wavelength of 223 nm, after at least about 24 months of storage at a temperature of from about 5° C. to about 25° C.

A cosmetic preparation containing 4-Hydroxy-3-methoxybenzaldehyde (INCI: vanillin), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine), dipropylene glycol dibenzoate (INCI: dipropylene glycol dibenzoate) and benzyl benzoate (INCI: benzyl benzoate).

The invention discloses a TOPCon front slurry organic carrier and application, and belongs to the technical field of solar cells, the TOPCon front slurry organic carrier comprises the following raw materials by mass: 2.5%-14% of resin, 75%-87% of a solvent, 1%-7% of a thixotropic agent, and 1%-5% of an auxiliary agent; the resin comprises ethyl cellulose, cellulose acetate butyrate and acrylic resin; the solvent comprises triethylene glycol monobutyl ether, dodecanol ester, diethylene glycol monobutyl ether acetate and benzyl benzoate; the thixotropic agent comprises polyamide wax, a modified polyurea compound and phenoxyethanol; the thixotropic agent comprises polyamide wax, a modified polyurea compound and phenoxyethanol; by adjusting and verifying the variety and proportion of the raw materials of the organic carrier, the printability, fluidity and plasticity of the TOPCon front paste are optimized, and the TOPCon front paste has the advantages of good conductivity, wettability, printability and the like.

The invention discloses a high-selectivity ester biosynthesis method based on key site modification of alcohol acyltransferase, and relates to the field of gene engineering. Through a molecular docking technology, the fact that the F302 site of FaAAT plays a key role in synthesis selectivity of geranyl butyrate is determined for the first time, NDT type site-directed mutagenesis and acid alcohol substrate proportion optimization are combined, the synthesis efficiency of target ester is remarkably improved, and the selectivity of the mutant FaAAT-F302N is superior to that of a wild type. The site mutation has a broad-spectrum effect, and shows better selectivity in various acid-alcohol substrate combinations. According to the invention, the technology is further expanded to FaAAT2 and PmBABT systems, and high-selectivity synthesis of geranyl butyrate and benzyl benzoate is respectively realized through similar mutation and acid / alcohol molar ratio optimization. Based on a universal strategy of key site rational design and substrate proportion optimization, the catalytic selectivity of the alcohol acyltransferase is effectively improved, and a new method is provided for efficient and green synthesis of various ester perfume molecules.

The invention discloses a preparation method of an antibacterial anti-mite blanket, and belongs to the technical field of blanket preparation. The preparation method of the antibacterial and anti-mite blanket is used for solving the technical problem that in the prior art, the antibacterial and anti-mite performance of the blanket needs to be further improved, and comprises the following steps that non-woven fabric is soaked in antibacterial finishing liquid according to the soaking ratio of 1: (30-32), and pretreatment base cloth is obtained after aftertreatment. Benzyl benzoate is used as an anti-mite active component, anti-mite capsules are prepared through crosslinking of sodium alginate, polyvinyl alcohol and delta-glucolactone, the anti-mite capsules are doped into a polyacrylonitrile and dimethylformamide system, modified fibers are prepared through electrostatic spinning, then chitosan and polyhexamethylene biguanide hydrochloride are used as main materials to construct an anti-bacterial finishing liquid, and the anti-mite finishing liquid is prepared through electrostatic spinning. And finally, the antibacterial and anti-mite blanket is obtained through polyurethane hot-pressing compounding, so that not only is the antibacterial and anti-mite performance of the blanket improved, but also the mechanical property of the blanket is improved.

The invention discloses compound plant essential oil with an anti-depression effect, and belongs to the technical field of anti-depression treatment. The compound plant essential oil comprises the following components in percentage by mass: 0-30% of lavender essential oil, 0-25% of sweet orange essential oil, 0-15% of cananga odorata essential oil and 60-70% of propylene glycol. The preparation method of the compound plant essential oil comprises the following steps: sequentially adding the lavender essential oil, the sweet orange essential oil and the cananga odorata essential oil into the propylene glycol according to the mass fraction, and uniformly stirring to obtain the compound plant essential oil. Among the three essential oils, the sweet orange essential oil significantly improves subjective pleasure, and the main component limonene is the key; the lavender essential oil and the cananga odorata essential oil stabilize emotion by adjusting Alpha waves and Beta waves, the lavender essential oil contains linalool and linalyl acetate, the cananga odorata essential oil mainly contains benzyl benzoate and linalool, the three essential oils are compounded for use, the occipital leaf Alpha wave power is remarkably improved, the temporal leaf Beta wave power is reduced, the synergistic effect of relaxation and pleasure is achieved, and the effects of relieving depressive emotion, relaxing mood, relieving fatigue, relieving fatigue and the like can be achieved. The appetite is improved.

The invention discloses a preparation method of a heat-conducting enhanced photo-thermal anti-icing coating, which specifically comprises the following steps: mixing boric acid and urea, calcining to generate BN powder, and carrying out ball milling treatment on the BN powder and benzyl benzoate to prepare BNNSs; the preparation method comprises the following steps: modifying, dispersing and mixing BNNSs and CNTs to prepare a BNNSs (at) CNTs composite material; dissolving AOZ in dichloromethane, dropwise adding the solution into the BNNSs (at) CNTs dispersion liquid, and carrying out a reaction so as to obtain AOZ-BNNSs (at) CNTs; after being modified, the material is mixed with EP and an auxiliary agent to prepare a composite coating; and finally, mixing the composite coating with a curing agent and a curing accelerator, and spraying the mixture on the metal surface to form the heat-conducting enhanced photo-thermal anti-icing coating. The prepared coating is sprayed on the metal surface, efficient light collection, temperature rise and ice prevention can be achieved, the surface is hydrophobic after curing, the low-temperature ice resistance is enhanced, and the coating has wide application prospects in the key fields of electric wires and cables, aerospace, transportation and the like.

1. The name of the design product: packing bottle (inner bottle of 25% benzoic acid benzyl ester bacteriostatic solution of Kaimenda). 2. The use of the design product: for packing bottle. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

The invention discloses a repellent for pollinating insect wood bees harmful to building wood members and application of the repellent. The repellent comprises 0-1 part of an alpha-phellandrene solution, 0-1 part of a mint volatile oil solution, 0-1 part of a lantana essential oil solution, 0-1 part of a benzoin solution, 0-1 part of a vanillic aldehyde solution, 0-1 part of a limonene solution, 0-1 part of a benzyl benzoate solution, 0-1 part of a diethyl fumarate solution, 0-1 part of an isoamyl salicylate solution, 0-1 part of a benzyl acetate solution and 0-1 part of an anisyl acetate solution. The repellent disclosed by the invention mainly has a remarkable repelling effect on the female wasps, is used for spraying or dipping the female wasps to be loaded on wood components in the early stage of site selection and nesting of the female wasps to prevent the female wasps from leaving the wood components of ancient buildings and target buildings without causing death of the female wasps, and has the advantages of simplicity and convenience in preparation, greenness, high efficiency and the like. The composition can be independently used as a wood bee repellent, can also be used in combination with a wood preservative, and is used for comprehensive treatment of wood bees and other pests of building wood components.

This invention discloses a plum blossom fragrance and its artificial preparation method, belonging to the field of fragrance and flavor technology. The plum blossom fragrance is composed of the following components by mass percentage: cinnamyl alcohol 60.8%-74.4%, eugenol 4.5%-5.6%, benzyl acetate 0.2%-0.3%, 3-phenylpropanol 1.3%-1.7%, cinnamyl acetate 1.1%-1.3%, benzaldehyde 1.1%-1.3%, 4-vinylphenol 17.7%-21.6%, benzyl benzoate 3%-3.7%, nonanal 0.06%-0.1%, and hexanal 0.02%-0.05%. The obtained plum blossom fragrance has a similarity of up to 7.25 / 10 to the aroma of natural plum blossoms, and has advantages such as high aroma reproduction and controllable cost.

The invention discloses application of ketoisophorone and benzyl benzoate in preparation of a medicine for treating diabetes, and belongs to the technical field of biological medicine. In-vivo and in-vitro studies find that after a T2DM animal model and a GlcN cell model are treated through KSP independent administration, BZT independent administration and KSP and BZT 1: 3 combined administration, compared with a model group, the blood glucose regulation effect of a combined administration group is most remarkable: the area under an fasting blood glucose and oral glucose tolerance test (OGTT) curve is in dose-dependent reduction, and the area under the curve is in dose-dependent reduction; an insulin tolerance test (ITT) result shows that the insulin sensitivity is obviously improved; in animal experiments, glycogen generation in liver tissues is increased, and balloon-like deformation and fatty degeneration accumulation conditions are relieved.