62 results about "Primary alcohol" patented technology

The invention discloses a photosensitive polyimide, a negative photoresist and an application of the photosensitive polyimide in preparation of a film, the structure of the photosensitive polyimide is shown in the specification, X is a tetravalent organic group and is a residue X of a polyimide polymerization monomer tetracarboxylic dianhydride; y is a divalent organic group and is a residue Y of a polyimide polymerization monomer diamine; r1 and R2 are monovalent organic groups and are residues of primary alcohol forming side chain ester bonds of side chain polyamic acid ester; side chains R1 and R2 at least contain tertiary amine structures, and at least one of the side chains R1 and R2 containing the tertiary amine structures can form ammonium salt with phosphate containing an allyl structure; and n is an integer from 2 to 150. The invention provides a photosensitive polyimide which can be developed by adopting an alkaline aqueous solution, can be cured at low temperature and can form a negative pattern, a preparation method of a photoresist composition of the photosensitive polyimide, and a photoetching curing film, which can be applied to display industry or semiconductor industry as an insulating layer, a passivation layer or an interlayer dielectric layer and the like.

The present application relates to the technical field of organic synthesis, and particularly relates to a method for preparing (+)-crispine A by means of biological enzyme resolution. First, 6,7-dimethoxy-3,4-dihydroisoquinoline-2-oxide is subjected to 1,3-dipolar cycloaddition with allyl alcohol to obtain a first compound; then the first compound is added into a sulfonylation reagent and zinc powder to obtain a racemate second compound through a three-step continuous series reaction of primary alcohol sulfonylation, nitrogen-oxygen bond cleavage and ring formation; then the second compound is mixed with vinyl acetate and biological enzyme, and chiral resolution is carried out under the action of the biological enzyme to obtain a third compound with right-handed optical rotation and a fourth compound with left-handed optical rotation; finally, the third compound is mixed with an alkaline reagent and a sulfonylation reagent, and then secondary alcohol sulfonylation is carried out to obtain a fifth compound with right-handed optical rotation; the fifth compound is mixed with a deoxidizing reagent to carry out deoxidation reaction, and (+)-crispine A is prepared. The method is simple, green and environmentally friendly, and can be produced in large quantities.

A process for preparing polyisobutene from isobutene in the presence of a Lewis Acid and an initiator characterised by feeding linear and / or branched C5-C8 primary alcohol, oxidising of the primary a

The application provides a preparation method of MK-0616 south fragment, and relates to the technical field of polypeptide synthesis. The preparation method comprises the following steps: condensation reaction of alkyl primary alcohol 17 and protected amino acid 2 to obtain intermediate 18; deprotection reaction of the intermediate 18 to obtain intermediate 19; condensation reaction of the intermediate 19 and compound 4 to obtain intermediate 20; deprotection reaction of the intermediate 20 to obtain intermediate 21; condensation reaction of the intermediate 21 and compound 10 to obtain intermediate 22; deprotection reaction of the intermediate 22 to obtain intermediate 23; condensation reaction of the intermediate 23 and compound 14 to obtain intermediate 24; hydrolysis reaction of the intermediate 24 to obtain a crude product of MK-0616 south fragment; salt crystallization of the crude product of MK-0616 south fragment to obtain intermediate 15; and free acidization of the intermediate 15 to obtain a pure product of MK-0616 south fragment.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

This application relates to the technical field of traditional Chinese medicine compositions, specifically disclosing a traditional Chinese medicine composition for treating deficiency syndromes caused by illness, surgery, radiotherapy, and chemotherapy, and its preparation process. The composition comprises Ganoderma lucidum extract and ginseng powder. The preparation method of the Ganoderma lucidum extract is as follows: Step 1, pulverizing the raw material to obtain Ganoderma lucidum powder; Step 2, extraction: extracting the Ganoderma lucidum powder with a primary liquid-liquid phase solvent for 1.5-2.5 hours, adding non-oxidizing gas nano-bubble water and extracting for 0.5-1.5 hours, then adding acidic gas nano-bubble water and continuing extraction for 0.5-1.5 hours; Step 3, collection: collecting the extract, concentrating, forming a paste, and drying to obtain the Ganoderma lucidum extract; the primary liquid-liquid phase solvent includes an alcohol solution with a volume ratio of (2-5):1 and a non-polar organic solvent, with the alcohol volume percentage in the primary alcohol solution being 65-90%. The composition of this application has a higher content of Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenes.

The invention discloses a preparation method of (a / b)-D-fucose and fucose tetraacetate, and belongs to the technical field of organic synthesis. The preparation method of the (a / b)-D-fucose and fucose tetraacetate is based on a PPh3 / NBS method, the PPh3 / NBS combination is a method for efficiently, highly selectively and mildly converting primary alcohol and secondary alcohol into corresponding alkyl bromide, and the core of the method is to generate Ph3PBr2 to activate hydroxyl. In the whole process, reaction conditions are mild, treatment is simple, needed drugs are cheap and easy to obtain, most of intermediate products are synthesized through a one-pot method, few intermediate products need to be separated and purified through silica gel column chromatography, the operation time of follow-up experimental treatment and separation and purification is omitted, and the time of the whole reaction process is greatly shortened. In addition, due to the fact that repeated purification is not needed, the final yield is guaranteed, the total yield can reach 17%, and the gram level can be reached at a time.

This invention provides a method for preparing tert-butyl 2-hydroxymethylbenzoate, the method comprising the following steps: (1) reacting tert-butyl hydrogen phthalate and isobutyl chloroformate to obtain compound 1, (2) reacting compound 1 to obtain tert-butyl 2-hydroxymethylbenzoate; the preparation method provided by this invention has a high yield and stable process, the post-processing is relatively simple, it can avoid operations such as column chromatography, and the reagents used are all conventional reagents, which reduces the production cost and is applicable to industrial scale-up production, providing technical support for the reduction of carboxylic acid compounds into primary alcohols.

This invention discloses carboxymethyl sucrose amino acid salts, their preparation, compositions, and applications. The salts are prepared from carboxymethyl sucrose and arginine, or carboxymethyl sucrose and glycine, through a chemical reaction. The resulting salts undergo a series of processes including primary alcohol precipitation, redissolution, secondary alcohol precipitation, redissolution, tertiary alcohol precipitation, soaking, pulverization, filtration, and drying to obtain carboxymethyl sucrose arginine and carboxymethyl sucrose glycine salts. A composition is prepared by mixing these two salts. Both salts and the composition significantly inhibit the activity of matrix metalloproteinase 1 and promote the expression of type I collagen, thus delaying aging by maintaining the stability of collagen morphology and structure in the extracellular matrix. The preparation method of this invention is simple and the process conditions are mild. The product has the advantages of being weakly acidic, gentle on the skin, highly safe, and having good anti-aging effects. It can be widely used in skin care cosmetics and has promising application prospects.

The present invention relates to the technical field of polyurethane compositions, particularly to a polyurethane composition and a polyurethane composite material, the polyurethane composition comprises an isocyanate component, an isocyanate reactive component, a catalyst and an optional auxiliary agent, the viscosity of the isocyanate reactive component at 25 DEG C is 400-700 mPa.s; the isocyanate reactive component includes: a low viscosity polyol; the viscosity at 25 DEG C is smaller than or equal to 200 mPa.s, the hydroxyl value is larger than or equal to 1000 mgKOH / g, and the primary alcohol is the primary alcohol with the average functionality larger than or equal to 2; the time required for increasing the real-time mixing viscosity eta t of the isocyanate component and the isocyanate reactive component by 100% at 25 DEG C compared with the initial mixing viscosity eta 0 is t, and t is greater than or equal to 200 s and greater than or equal to 660 s. The polyurethane composition disclosed by the invention is applied to a composite material pultrusion process, rapid pultrusion can be realized, the pultrusion efficiency of polyurethane is remarkably improved, and meanwhile, the performance of an obtained composite material is excellent.

The present invention relates to a multi-component resin system comprising (i) at least one resin component (A) comprising at least one curable epoxy resin and (ii) at least one curing agent component (B) comprising at least one primary alcohol and copper (II) tetrafluoroborate. The present invention further relates to the use of such a multi-component resin system for the chemical fastening of construction elements in holes (for example boreholes) or gaps, and the use as an adhesive or as a coating.

This invention provides a method for efficiently producing aliphatic aldehydes by oxidizing aliphatic primary alcohols having four or more carbon atoms. [Solution] A method for producing an aliphatic aldehyde, comprising the step of oxidizing an aliphatic primary alcohol having 4 or more carbon atoms with molecular oxygen in the presence of a ruthenium-supported catalyst, The ruthenium-supported catalyst comprises ruthenium supported on a carrier, The aforementioned support is a porous oxide, The surface area per unit mass of ruthenium is 60 m². 2 / g or more The mesopore volume of the ruthenium-supported catalyst is 0.15 mL / g or more. A method for producing aliphatic aldehydes.

A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.

The present invention relates to process of alkylating a ketone of the formula (I) with an alcohol of the formula (II) having at least one primary and optionally at least one secondary hydroxyl group in the presence of an iron catalyst of the formula (III).

The present application relates to the chemical technology field, specifically to a kind of preparation method of high-purity o-vanillin.The method uses o-methoxyphenylamine as starting material, with chloral hydrate and hydroxylamine hydrochloride is condensed, hydroxylamine oximation reaction, and cyclization reaction is carried out under strong acid condition, and compound 2 is generated;Compound 2 is oxidized under strong base condition, and compound 3 is generated;Compound 3 is esterified with primary alcohol to generate corresponding ester, and then reduction hydrogenation reaction is carried out under the action of strong reducing agent, and compound 4 is generated;Compound 4 is reacted with oxidizing agent in the presence of nitroxyl radical catalyst, and compound 5 is generated;Compound 5 carries out diazotization hydrolysis reaction, and o-vanillin is generated.The method avoids the problem of regioselectivity of traditional formylation reaction through specific reaction sequence, eliminates the generation of isomer impurities from the source, realizes the efficient, environmentally friendly, economic synthesis of high-purity o-vanillin, and provides high-quality raw material guarantee for downstream pharmaceutical.

The present application provides a demercaptan agent consisting of: (1) at least one aminocarboxylate salt containing a primary amine group, a secondary amine group or a tertiary amine group, (2) at least one alcohol amine being a primary alcohol amine, a secondary alcohol amine or a tertiary alcohol amine, and (3) water. The present application also provides a preparation method and use of the demercaptan agent and a method for removing mercaptans from liquefied petroleum gas using the demercaptan agent. The demercaptan agent of the present application removes mercaptans by extraction without using inorganic bases such as sodium hydroxide, and the regenerated demercaptan agent can be regenerated by steam stripping, recycled and used, and no alkali residue is discharged. The demercaptan agent of the present application can be used for removing mercaptans from liquefied petroleum gas, and the total sulfur content of refined liquefied petroleum gas can be reduced to 5 μg·g ‑1 The following.

The application discloses a method for preparing a pyrimidine derivative by catalyzing lignin conversion through a rhodium-based catalyst. The method takes real lignin as a substrate, takes amidine hydrochloride and a primary alcohol as reaction raw materials, and utilizes the rhodium-based catalyst to prepare the pyrimidine derivative in an air atmosphere through a one-pot two-step method under alkaline conditions. The method for preparing the pyrimidine derivative from the real lignin is realized, and the method has the advantages of simplicity, high product selectivity, mild reaction conditions and the like.

This invention belongs to the field of organic synthesis technology, specifically relating to a method for synthesizing a carboxyl-containing adamantane methacrylate resin monomer. The synthesis method includes the following steps: S1: 3-hydroxyadamantane-1-carboxylic acid is reacted with concentrated sulfuric acid and a primary alcohol to obtain methyl 3-hydroxyadamantane-1-carboxylic acid; S2: methyl 3-hydroxyadamantane-1-carboxylic acid is esterified in a reaction containing methacryloyl chloride, triethylamine, and dichloromethane to generate methyl 3-methacrylate-adamantane-1-carboxylic acid; S3: methyl 3-methacrylate-adamantane-1-carboxylic acid is subjected to an alkaline hydrolysis reaction in a reaction containing methacryloyl chloride, alkaline solution, water, and a secondary alcohol to obtain a carboxyl-containing adamantane methacrylate resin monomer. This invention solves the technical problems of low esterification conversion rate, large raw material residue, and easy polymerization of the product due to the presence of carboxyl groups in the resin monomer, making industrial-scale production impossible.

The invention discloses a preparation method and application of a series of novel chiral polydentate amino alcohol ligands. The synthesis method comprises the following steps: preparing primary alcohol type chiral amino alcohol by taking L-amino alcohol and 2-halogenated heteroaromatic ring as raw materials and carrying out nucleophilic substitution reaction in one step; the tertiary alcohol type chiral amino alcohol is prepared by taking L-leucine as a raw material, and sequentially carrying out methyl esterification, Buchwald-Harwig cross-coupling reaction and phenyl magnesium bromide addition reaction to synthesize the tertiary alcohol type chiral amino alcohol. The method disclosed by the invention is simple in process, mild in reaction condition, cheap and easily available in raw materials, easy in product separation and purification and high in yield; and the prepared chiral polydentate amino alcohol ligand can be applied to identification of camphorsulfonic acid enantiomers and determination of enantiomer excess (ee value).

This invention provides a method for producing aliphatic aldehydes in high yield by oxidizing aliphatic primary alcohols having four or more carbon atoms. [Solution] A method for producing an aliphatic aldehyde, comprising the step of oxidizing an aliphatic primary alcohol having 4 or more carbon atoms with molecular oxygen in the presence of an N-oxyl compound and / or an N-oxide compound and a metal-supported catalyst, The metal-supported catalyst includes a metal supported on an inorganic support, A method for producing an aliphatic aldehyde, wherein the N-oxyl compound and / or N-oxide compound is one or more selected from the group consisting of compounds represented by general formula (I), compounds represented by general formula (II), and compounds represented by general formula (III). [Formula 1] JPEG2026104778000025.jpg37124

NON-SOLID COSMETIC COMPOSITION WITH A NON-POLAR VOLATILE HYDROCARBONATE OIL, A SOLVENT WITH ALCOHOL, ACID, AMINE OR AMIDE FUNCTIONS AND A SILICONE ELASTOMER WITH CARBOXYLIC ACID FUNCTIONS The present invention relates to a non-solid composition for the care and / or makeup of keratinous materials, in particular skin, comprising, preferably in a physiologically acceptable medium: a) an oily phase comprising i) at least one non-polar volatile hydrocarbon oil H1 and ii) at least one liquid hydrocarbon solvent of a molecular mass less than 600 g / mol comprising at least one alcohol, carboxylic acid, amine or amide function and mixtures thereof; provided that when the liquid hydrocarbon solvent is a primary alcohol, it comprises at least 3 carbon atoms, and b) at least one silicone elastomer with a carboxylic acid function;the weight ratio between the total quantity of volatile oil(s) and the total quantity of hydrocarbon liquid solvent(s) ii) being less than or equal to 20.0. The invention also relates to a method for coating keratinous materials, more particularly for makeup and / or skincare of keratinous materials, such as skin, characterized in that it comprises applying to the keratinous materials a composition as defined above. Figure for the abstract: none;

The present invention relates to a process for the preparation of at least one blocked polyisocyanate comprising the following steps: (A) reacting at least one polyisocyanate with at least one thermally cleavable blocking agent selected from the group consisting of monofunctional primary alcohols and mixtures thereof to obtain at least one partially blocked polyisocyanate, (B) reacting the at least one partially blocked polyisocyanate from step (A) with at least one non-ionic hydrophilizing agent to obtain an intermediate, and (C) reacting the intermediate obtained in step (B) with at least one thermally cleavable blocking agent selected from the group consisting of monofunctional primary alcohols and mixtures thereof to obtain the at least one blocked polyisocyanate, to the blocked polyisocyanate obtained in a corresponding manner, to the use of the blocked polyisocyanate for the production of a coating composition, an adhesive, a sealant or an elastomer, to the corresponding coating composition, adhesive, sealant or elastomer, and to a substrate with a coating obtained using the at least one blocked polyisocyanate of the present invention.

This invention provides a means to suppress the occurrence of wrinkles in textile products caused by the washing process. [Solution] A method for processing textile products, comprising: step 1: drying the textile products until the moisture content is 1 to 40%; step 2: treating the textile products from step 1 with a textile processing agent composition; and step 3: further drying the textile products from step 2, wherein the textile processing agent composition contains (A) (A1) a silicone compound and / or (A2) a cationic surfactant, and (B) at least one compound selected from the group consisting of primary alcohols having 2 to 3 carbon atoms, glycols having 2 to 6 carbon atoms, and polyhydric alcohols having 3 to 8 carbon atoms.

Provided is a production method with which it is possible to efficiently produce an aliphatic aldehyde by oxidizing a C4 or higher aliphatic primary alcohol. A method for producing an aliphatic aldehyde including a step for oxidizing a C4 or higher aliphatic primary alcohol using molecular oxygen in the presence of a ruthenium-supported catalyst, wherein the ruthenium-supported catalyst contains ruthenium supported on a carrier, the carrier is a porous oxide, the surface area per unit mass of the ruthenium is 60 m2 / g or greater, and the mesopore volume of the ruthenium-supported catalyst is 0.15 mL / g or greater.

The invention discloses a method for carrying out difluoromethoxy conversion on alcohol, and relates to the technical field of organic chemical synthesis. According to the invention, under mediation of light and acid, hydroxyl of alcohol can react with bpyCu (CF3) 3 to realize difluoromethoxylation; the alcohol difluoromethoxylation reaction provided by the invention has the advantages that the substrate universality is good, the alcohol difluoromethoxylation of primary alcohol, secondary alcohol, tertiary alcohol and even polyhydroxy compounds can be realized, the compound types of the difluoromethoxylation compounds can be expanded, and the full research of the difluoromethoxylation compounds can be further realized.

To provide a metal-containing additive and a crosslinkable polymer composition that each contain a β-diketonato metal complex and have excellent storage stability, and provide a crosslinked polymer material, a metal member, and a wire harness that are each produced using such a crosslinkable polymer composition. The metal-containing additive includes the β-diketonato metal complex and a primary alkyl alcohol having 4 to 30 carbon atoms. The crosslinkable polymer composition includes the metal-containing additive and an organic polymer, where the organic polymer has a substituent capable of forming ionic bonds with metal ions released by heat from the metal-containing additive.

To overcome the problems of difficult reaction equilibrium control, complex production processes, high costs, and low yields in existing technologies, this invention provides a method for preparing polyol carbonate esters, comprising the following steps: mixing and heating a primary alcohol, a carbonate, a secondary alcohol, and a catalyst, stirring until homogeneous, and purifying to obtain the polyol carbonate ester. The primary alcohol contains 3 or more hydroxyl groups, and the secondary alcohol is either a monohydric alcohol or a dihydric alcohol. The method for preparing polyol carbonate esters provided by this invention, by adding a secondary alcohol to regulate the reaction equilibrium, significantly improves the yield. The purified product has high purity, and the production process is simple and low-cost.

The invention provides a degradation agent for target protein degradation and a preparation method thereof, and relates to the field of target protein degradation. The degradation agent for target protein degradation is prepared from the following components in parts by weight: 1 to 2 parts of ZDHHC20 ligand, 1 to 2 parts of E3 ligase ligand, 2 to 4 parts of linker, 0.8 to 1.2 parts of halogenated hydrocarbon, 0.8 to 1.5 parts of Lewis acid, 1 to 2 parts of pyridinium chlorochromate, 2 to 3 parts of acetonitrile, 0.6 to 0.8 part of primary alcohol, 2 to 3 parts of alkali and 1 to 2 parts of aromatic compound. According to the degradation agent for target protein degradation provided by the invention, the pyridinium chlorochromate, the aromatic compound and the halogenated hydrocarbon are combined for use, so that basic chemical modification and comprehensive coverage of characteristics of a final product can be realized, firstly, carboxyl with relatively high activity is introduced through the pyridinium chlorochromate; the preparation method comprises the following steps: firstly, preparing the ZDHHC20, then improving the stability and targeting ability of molecules through an aromatic compound, finally completing a key chemical bond forming step by virtue of halogenated hydrocarbon and lewis acid, and indirectly recovering the functions of the cancer suppressor proteins and promoting cancer cells to enter an apoptosis procedure by degrading the ZDHHC20 or adjusting the activity of the ZDHHC20.

The application provides a synthesis method of deoxycholic acid (DCA). The method takes phytosterol as a starting material, and synthesizes deoxycholic acid (DCA) through a series of steps such as primary alcohol oxidation reaction, witting reaction, hydrogenation reaction, selective reduction reaction, hydroxyl protection reaction, elimination reaction, allyl oxidation reaction and hydrolysis reaction. The synthesis method has high reaction yield and high product purity, the intermediates in each step are all solid, easy to purify, the post-treatment method is simple, the cost is low, suitable for quality control, convenient for industrialized production, and has a good application prospect. Moreover, the deoxycholic acid (DCA) synthesized by the method also avoids the risk of containing animal pathogens and other harmful factors.