131 results about "Primary alcohol" patented technology

This application relates to the technical field of astragalus polysaccharides, and specifically relates to a method for extracting astragalus polysaccharides. A method for extracting astragalus polysaccharides includes the following steps: primary water extraction, secondary water extraction, vacuum concentration, primary alcohol precipitation, secondary alcohol precipitation, and purification. Among them, in the primary water extraction: soak astragalus with a weak alkaline solution, then heat to boiling and carry out extraction, and filter to separate the primary precipitate and the primary extract. By using a weak alkaline solution in the primary water extraction step, this application destroys cell walls, increases the solubility of polysaccharides, and promotes the release of polysaccharides, significantly improving the extraction rate of astragalus polysaccharides.

The present invention relates to the technical field of the preparation of polyols. Disclosed are a method for preparing a bio-based polyol and a use of the bio-based polyol. In the present invention, a tartrate is selected as a first ring-opening reagent to carry out a first ring-opening reaction on an epoxy group, a second ring-opening reagent containing a secondary alcohol is then used to carry out a second ring-opening reaction, and finally, a primary alcohol is used to carry out a third ring-opening reaction on the rest epoxy group to obtain a bio-based polyol product having an epoxy value close to 0. The bio-based polyol prepared in the present invention is moderate, has a uniform distribution and a relatively low viscosity, and can replace traditional petrochemical polyols. A polyurethane coating prepared from the bio-based polyol prepared by the method of the present invention has remarkably improved performance.

The invention discloses a photosensitive polyimide, a negative photoresist and an application of the photosensitive polyimide in preparation of a film, the structure of the photosensitive polyimide is shown in the specification, X is a tetravalent organic group and is a residue X of a polyimide polymerization monomer tetracarboxylic dianhydride; y is a divalent organic group and is a residue Y of a polyimide polymerization monomer diamine; r1 and R2 are monovalent organic groups and are residues of primary alcohol forming side chain ester bonds of side chain polyamic acid ester; side chains R1 and R2 at least contain tertiary amine structures, and at least one of the side chains R1 and R2 containing the tertiary amine structures can form ammonium salt with phosphate containing an allyl structure; and n is an integer from 2 to 150. The invention provides a photosensitive polyimide which can be developed by adopting an alkaline aqueous solution, can be cured at low temperature and can form a negative pattern, a preparation method of a photoresist composition of the photosensitive polyimide, and a photoetching curing film, which can be applied to display industry or semiconductor industry as an insulating layer, a passivation layer or an interlayer dielectric layer and the like.

The invention provides polyamide acid ester, photosensitive polyimide resin, a negative photoresist composition and application thereof. A covalent bond on a side chain of the polyamic acid ester contains a benzoylmethyl-containing structure, the structure has an ultraviolet light sensing function and can realize light degradation, so that the polyamic acid ester is converted into polyamic acid and primary alcohol, and the formed polyamic acid can be dissolved in a water-based developing agent, so that the targets of water-based developing and photoetching are realized. Besides, after the polyamic acid ester provided by the invention is imidized, no crosslinking component is left, and the polyamic acid ester has high mechanical property, high resolution, high film thickness and depth-to-width ratio gt; and 2.0, good performance can be achieved even if low-temperature curing is carried out.

The preparation method comprises the following steps: dissolving a boric acid monomer in an organic solvent, adding monomers containing vicinal diol and primary alcohol at the same time, then adding a water removal agent, heating to 60-80 DEG C, and carrying out condensation reflux to obtain a mixed solution containing a boric acid ester chain extender; removing the organic solvent from the mixed solution containing the boric acid ester chain extender, and washing with a low-boiling-point solvent to obtain a chain extender containing a single boric acid ester bond; the preparation method comprises the following steps: reacting a chain extender containing a single boric acid ester bond, an organic metal or tertiary amine catalyst, polyether polyol and diisocyanate to obtain a single-component moisture-cured polyurethane prepolymer with the-NCO reservation amount of 4-8wt.%, and curing. The single-component moisture-curable polyurethane has excellent mechanical properties, the phenomena that the mechanical properties are reduced and the self-repairing efficiency is reduced after repeated damage-repairing are avoided, the safety and reliability of the material are greatly improved, and the service life is prolonged.

The present invention discloses a preparation method for synthesizing α-amino ketone compounds from fatty aldehydes and secondary amines, belonging to the technical field of organic chemical synthesis. The fatty aldehyde, secondary amine, and sodium percarbonate are added to a reaction vessel for mixing, and the reaction is carried out at a temperature of 95 to 115 °C for 16 to 24 hours. After purifying the reaction mixture, α-amino ketone compounds are obtained. The fatty aldehydes and secondary amines used in the method of the present invention are commercially available raw materials or are prepared from commercially available primary alcohols and primary amines through simple oxidation or reduction; the substrate has a wide range of applicability and is applicable to the above-mentioned various fatty aldehydes and secondary amines. The method of the present invention can be prepared only by oxidizing and rearranging with cheap and easily available sodium percarbonate, without the need for additional catalysts and additives, and has the characteristics of high economy, wide commercial sources, and environmental friendliness; the method of the present invention has few reaction steps and has the characteristic of simple operation.

The present invention relates to the field of photocatalytic alcohol oxidation, and more particularly to a TiO2 / NaBr photocatalytic system for selectively oxidizing primary alcohols to produce acids under mild conditions. The present invention utilizes TiO2 as a primary catalyst and a halide salt as a co-catalyst. In an organic solvent, a primary alcohol raw material is added, and the system is developed in situ under oxygen and blue LED visible light. This photocatalytic system can efficiently complex with primary alcohol compounds. At room temperature, under the pressure of an oxygen balloon, and using ethyl acetate as the reaction solvent, it can oxidize the hydroxyl groups in aromatic and aliphatic primary alcohols to the corresponding acids. This method offers the advantages of good product selectivity, high conversion efficiency, and mild conditions. Furthermore, the catalyst is easily recyclable and the production cost is low. This method is a successful example of the photocatalytic oxidation of the biomass alcohol platform compound n-butanol to n-butyric acid.

The invention relates to a process for obtaining isobutene from an isobutene containing C4-hydrocarbon mixture (1) in a plant comprising an etherification unit (3), a first distillation unit (5), an ether cleavage unit (10) and a second distillation unit (12), the process comprising: (a) contacting the C4-hydrocarbon mixture (1) with a primary alcohol (2) and reacting the mixture with the primary alcohol in the presence of an acidic catalyst to form the corresponding alkyl tert-butyl ether in the etherification unit (3); (b) distilling the reaction mixture (4) from the etherification unit (3) in the first distillation unit (5), a C4-hydrocarbon raffinate being withdrawn as the overhead product (6), and the alkyl tert-butyl ether being withdrawn as the bottom product (7); (c) vaporizing the bottom product from the first distillation unit (5) in an evaporator (8) obtaining a vapor stream (9); (d) reacting the vapor stream (9) of step (c) in the presence of an acidic catalyst obtaining isobutene and the primary alcohol as reaction products in the ether cleavage unit (10); (e) distilling the reaction mixture (11) from the ether cleavage unit (10) in the second distillation unit (12), isobutene being withdrawn as the overhead product (13), the primary alcohol and diisobutene being withdrawn as the bottom product (14) and being recycled to the etherification unit (3); wherein a purge stream (15) containing high boiling components with a normal boiling point higher than that of the alkyl tert-butyl ether is withdrawn from the evaporator (8) in step (c).

The present application relates to the technical field of organic synthesis, and particularly relates to a method for preparing (+)-crispine A by means of biological enzyme resolution. First, 6,7-dimethoxy-3,4-dihydroisoquinoline-2-oxide is subjected to 1,3-dipolar cycloaddition with allyl alcohol to obtain a first compound; then the first compound is added into a sulfonylation reagent and zinc powder to obtain a racemate second compound through a three-step continuous series reaction of primary alcohol sulfonylation, nitrogen-oxygen bond cleavage and ring formation; then the second compound is mixed with vinyl acetate and biological enzyme, and chiral resolution is carried out under the action of the biological enzyme to obtain a third compound with right-handed optical rotation and a fourth compound with left-handed optical rotation; finally, the third compound is mixed with an alkaline reagent and a sulfonylation reagent, and then secondary alcohol sulfonylation is carried out to obtain a fifth compound with right-handed optical rotation; the fifth compound is mixed with a deoxidizing reagent to carry out deoxidation reaction, and (+)-crispine A is prepared. The method is simple, green and environmentally friendly, and can be produced in large quantities.

The invention provides a kinetic resolution method for asymmetric catalytic hydrogenation of racemic beta-aryl ester or lactone. Specifically, the invention provides a kinetic resolution method for asymmetric catalytic hydrogenation of racemic beta-aryl ester or lactone containing aryl, alkenyl, alkynyl and alkyl, and chiral gamma-aryl primary alcohol is prepared. According to the method, a chiral Ir-SpiroPAP catalyst or an enantiomer thereof is adopted, and the conversion number of the chiral Ir-SpiroPAP catalyst is as high as 600. In the imgabs0 #, R can be aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkyl or cyclic alkyl; r2 is alkyl; x can be hydrogen, alkyl, alkoxy, halogen or carboxylic ester group; wherein the structural formula of the Ir-SpiroPAP catalyst is # imgabs 1 # or an enantiomer thereof, and Y is hydrogen or alkyl.

A process for preparing polyisobutene from isobutene in the presence of a Lewis Acid and an initiator characterised by feeding linear and / or branched C5-C8 primary alcohol, oxidising of the primary a

The application provides a preparation method of MK-0616 south fragment, and relates to the technical field of polypeptide synthesis. The preparation method comprises the following steps: condensation reaction of alkyl primary alcohol 17 and protected amino acid 2 to obtain intermediate 18; deprotection reaction of the intermediate 18 to obtain intermediate 19; condensation reaction of the intermediate 19 and compound 4 to obtain intermediate 20; deprotection reaction of the intermediate 20 to obtain intermediate 21; condensation reaction of the intermediate 21 and compound 10 to obtain intermediate 22; deprotection reaction of the intermediate 22 to obtain intermediate 23; condensation reaction of the intermediate 23 and compound 14 to obtain intermediate 24; hydrolysis reaction of the intermediate 24 to obtain a crude product of MK-0616 south fragment; salt crystallization of the crude product of MK-0616 south fragment to obtain intermediate 15; and free acidization of the intermediate 15 to obtain a pure product of MK-0616 south fragment.

The invention discloses a diamine monomer, a transparent high-temperature-resistant polyester imide film prepared from the diamine monomer and application of the transparent high-temperature-resistant polyester imide film, the diamine monomer is synthesized from 4-aminobenzoic acid and binary primary alcohol or 4-nitrobenzoyl chloride and a phenolic compound, and ester groups with symmetrical structures are introduced into the chemical structure of the monomer, so that the diamine monomer can be synthesized into the transparent high-temperature-resistant polyester imide film. According to the preparation method of the high-temperature-resistant polyester imide film, the polyester imide synthesized with anhydride simultaneously contains imide bonds and ester bonds, so that the correspondingly prepared high-temperature-resistant polyester imide film not only has simple preparation method, but also has excellent optical performance, thermal performance and flexibility, has higher glass transition temperature while keeping higher optical transmittance, and can be used for preparing the high-temperature-resistant polyester imide film. Therefore, the material has good heat resistance and thermal stability, and has good application prospects in the fields of high-temperature-resistant optical films, flexible circuit substrates, lithium battery diaphragm coatings, photoelectric chip substrates and the like.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

This application relates to the technical field of traditional Chinese medicine compositions, specifically disclosing a traditional Chinese medicine composition for treating deficiency syndromes caused by illness, surgery, radiotherapy, and chemotherapy, and its preparation process. The composition comprises Ganoderma lucidum extract and ginseng powder. The preparation method of the Ganoderma lucidum extract is as follows: Step 1, pulverizing the raw material to obtain Ganoderma lucidum powder; Step 2, extraction: extracting the Ganoderma lucidum powder with a primary liquid-liquid phase solvent for 1.5-2.5 hours, adding non-oxidizing gas nano-bubble water and extracting for 0.5-1.5 hours, then adding acidic gas nano-bubble water and continuing extraction for 0.5-1.5 hours; Step 3, collection: collecting the extract, concentrating, forming a paste, and drying to obtain the Ganoderma lucidum extract; the primary liquid-liquid phase solvent includes an alcohol solution with a volume ratio of (2-5):1 and a non-polar organic solvent, with the alcohol volume percentage in the primary alcohol solution being 65-90%. The composition of this application has a higher content of Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenes.

The invention relates to a process for obtaining isobutene from an isobutene containing C4-hydrocarbon mixture (1) in a plant comprising an etherification unit (3), a first distillation unit (5), an ether cleavage unit (8) and a second distillation unit (10), the process comprising: (a) contacting the C4-hydrocarbon mixture (1) with a primary alcohol (2) and reacting the mixture with the primary alcohol in the presence of an acidic catalyst to form the corresponding alkyl tert-butyl ether as an intermediate product and diisobutene as a by-product in the etherification unit (3); (b) distilling the reaction mixture (4) from the etherification unit (3) in the first distillation unit (5), a C4-hydrocarbon raffinate being withdrawn as the overhead product (6), the alkyl tert-butyl ether and diisobutene being withdrawn as the liquid or vaporous bottom product (7), and vaporizing the bottom product (7) if it is withdrawn as a liquid; (c) reacting the vaporous bottom product (7) in the presence of an acidic catalyst obtaining isobutene and the primary alcohol as reaction products in the ether cleavage unit (8); (d) distilling the reaction mixture (9) from the ether cleavage unit (8) in the second distillation unit (10), isobutene being withdrawn as the overhead product (11), the primary alcohol and diisobutene being withdrawn as the bottom product (12) and being recycled to the etherification unit (3); the plant further comprising a byproduct separation unit (15) being fed by a bottom purge stream (13) of the first distillation unit (5) and / or by a part of the bottom product of the second distillation unit (10), this feed stream (14) being split up in at least three byproduct streams wherein a first byproduct stream (16) is rich in diisobutene, a second byproduct stream (17) is rich in the primary alcohol, and a third byproduct stream (18) is rich in components with a normal boiling point higher than 110° C.

The invention discloses a preparation method of (a / b)-D-fucose and fucose tetraacetate, and belongs to the technical field of organic synthesis. The preparation method of the (a / b)-D-fucose and fucose tetraacetate is based on a PPh3 / NBS method, the PPh3 / NBS combination is a method for efficiently, highly selectively and mildly converting primary alcohol and secondary alcohol into corresponding alkyl bromide, and the core of the method is to generate Ph3PBr2 to activate hydroxyl. In the whole process, reaction conditions are mild, treatment is simple, needed drugs are cheap and easy to obtain, most of intermediate products are synthesized through a one-pot method, few intermediate products need to be separated and purified through silica gel column chromatography, the operation time of follow-up experimental treatment and separation and purification is omitted, and the time of the whole reaction process is greatly shortened. In addition, due to the fact that repeated purification is not needed, the final yield is guaranteed, the total yield can reach 17%, and the gram level can be reached at a time.

This invention provides a method for preparing tert-butyl 2-hydroxymethylbenzoate, the method comprising the following steps: (1) reacting tert-butyl hydrogen phthalate and isobutyl chloroformate to obtain compound 1, (2) reacting compound 1 to obtain tert-butyl 2-hydroxymethylbenzoate; the preparation method provided by this invention has a high yield and stable process, the post-processing is relatively simple, it can avoid operations such as column chromatography, and the reagents used are all conventional reagents, which reduces the production cost and is applicable to industrial scale-up production, providing technical support for the reduction of carboxylic acid compounds into primary alcohols.

The present application relates to the technical field of heterogeneous catalysis, and provides a copper-silicon catalyst for catalyzing coupling of ethylene glycol and primary alcohol to synthesize long-chain vicinal diols, a preparation method therefor and a use thereof. The chemical general formula of the copper-silicon catalyst is CuxSi1-xO, wherein 0.01≤x≤0.3. The copper-silicon catalyst has good stability and high activity, and is easy to separate from a product when being used for synthesizing long-chain vicinal diols, the conversion rate of ethylene glycol and the selectivity of a product are high, and the copper-silicon catalyst can be reused.

This invention discloses carboxymethyl sucrose amino acid salts, their preparation, compositions, and applications. The salts are prepared from carboxymethyl sucrose and arginine, or carboxymethyl sucrose and glycine, through a chemical reaction. The resulting salts undergo a series of processes including primary alcohol precipitation, redissolution, secondary alcohol precipitation, redissolution, tertiary alcohol precipitation, soaking, pulverization, filtration, and drying to obtain carboxymethyl sucrose arginine and carboxymethyl sucrose glycine salts. A composition is prepared by mixing these two salts. Both salts and the composition significantly inhibit the activity of matrix metalloproteinase 1 and promote the expression of type I collagen, thus delaying aging by maintaining the stability of collagen morphology and structure in the extracellular matrix. The preparation method of this invention is simple and the process conditions are mild. The product has the advantages of being weakly acidic, gentle on the skin, highly safe, and having good anti-aging effects. It can be widely used in skin care cosmetics and has promising application prospects.

The objective of this invention is to provide a novel active ingredient useful for inhibiting aflatoxin production. With this invention, production of aflatoxin by an aflatoxin-producing fungus can be inhibited by means of a primary alcohol represented by formula (1): CH3—(CH2)n—OH (1) (where n is 0 or 2-4).

The purpose of the present invention is to provide a composition containing extracellular vesicles derived from microalgae. In one embodiment of the present invention, the composition contains (A) extracellular vesicles derived from microalgae, and, optionally, one or more chemicals selected from the group consisting of (B-1) to (B-3), where: (B-1) is one or more chemicals selected from the group consisting of primary alcohols and polyhydric alcohols, (B-2) is one or more chemicals selected from the group consisting of organic acids and salts thereof, and (B-3) is a chelating agent.

The invention relates to a bufalin derivative as well as a preparation method and application thereof, and belongs to the technical field of medicines. According to the invention, TEMPO oxidation reaction is adopted to selectively oxidize 19-site primary alcohol in 19-OH bufalin into aldehyde, so that 19-CHO bufalin is successfully synthesized, namely the bufalin derivative is obtained. The bufalin derivative has a remarkable killing effect on pancreatic cancer BxPC-3 cells, liver cancer HepG2 cells and brain glioma U-87MG cells, the IC50 of the bufalin derivative to the BxPC-3 cells is 40.63 nM, the IC50 of the bufalin derivative to the HepG2 cells is 36.74 nM, the IC50 of the bufalin derivative to the U-87MG cells is 28.73 nM, and the IC50 of the bufalin derivative to CHO-K1 cells is larger than 30 [mu] M, so that the bufalin derivative is relatively weak in toxicity to the heart, and the bufalin derivative has a remarkable killing effect on the liver cancer BxPC-3 cells, the liver cancer HepG2 cells and the brain glioma U-87MG cells. The compound can be applied to medicines for resisting pancreatic cancer, liver cancer and brain glioma.

The present invention relates to the technical field of polyurethane compositions, particularly to a polyurethane composition and a polyurethane composite material, the polyurethane composition comprises an isocyanate component, an isocyanate reactive component, a catalyst and an optional auxiliary agent, the viscosity of the isocyanate reactive component at 25 DEG C is 400-700 mPa.s; the isocyanate reactive component includes: a low viscosity polyol; the viscosity at 25 DEG C is smaller than or equal to 200 mPa.s, the hydroxyl value is larger than or equal to 1000 mgKOH / g, and the primary alcohol is the primary alcohol with the average functionality larger than or equal to 2; the time required for increasing the real-time mixing viscosity eta t of the isocyanate component and the isocyanate reactive component by 100% at 25 DEG C compared with the initial mixing viscosity eta 0 is t, and t is greater than or equal to 200 s and greater than or equal to 660 s. The polyurethane composition disclosed by the invention is applied to a composite material pultrusion process, rapid pultrusion can be realized, the pultrusion efficiency of polyurethane is remarkably improved, and meanwhile, the performance of an obtained composite material is excellent.

The present invention relates to a multi-component resin system comprising (i) at least one resin component (A) comprising at least one curable epoxy resin and (ii) at least one curing agent component (B) comprising at least one primary alcohol and copper (II) tetrafluoroborate. The present invention further relates to the use of such a multi-component resin system for the chemical fastening of construction elements in holes (for example boreholes) or gaps, and the use as an adhesive or as a coating.

This invention provides a method for efficiently producing aliphatic aldehydes by oxidizing aliphatic primary alcohols having four or more carbon atoms. [Solution] A method for producing an aliphatic aldehyde, comprising the step of oxidizing an aliphatic primary alcohol having 4 or more carbon atoms with molecular oxygen in the presence of a ruthenium-supported catalyst, The ruthenium-supported catalyst comprises ruthenium supported on a carrier, The aforementioned support is a porous oxide, The surface area per unit mass of ruthenium is 60 m². 2 / g or more The mesopore volume of the ruthenium-supported catalyst is 0.15 mL / g or more. A method for producing aliphatic aldehydes.

The invention discloses a radix fici simplicissimae polysaccharide extract and a preparation method and application thereof.The radix fici simplicissimae polysaccharide extract is radix fici simplicissimae crude polysaccharide or purified polysaccharide, and the radix fici simplicissimae crude polysaccharide is obtained by conducting primary alcohol precipitation, Sevage method protein removal and secondary alcohol precipitation on a radix fici simplicissimae water extract and then conducting drying; the purified polysaccharide is obtained by performing DEAE-52 fiber column chromatography on RFH, eluting by taking a sodium chloride solution as an eluent, respectively collecting elution parts of 0.3 mol / L sodium chloride solution, 0.4 mol / L sodium chloride solution and 0.5 mol / L sodium chloride solution, and respectively performing dialysis and drying. The radix fici simplicissimae polysaccharide extract prepared through a limited method can effectively activate macrophages to generate immunocompetence and is expected to be used for preparing immunomodulators or related drugs or food for enhancing the immunologic function.

A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.

The invention discloses a method for oxidizing primary alcohol into carboxylic acid. The invention relates to a method for producing carboxylic acids by oxidizing primary alcohols in the liquid phase in the presence of ruthenium dioxide as catalyst. The method using ruthenium dioxide as a liquid phase catalyst according to the present invention allows the desired carboxylic acid to be obtained with high selectivity, high weight hourly space velocity and thereby good space-time yield, and exhibits high robustness even after a prolonged reaction time.