88 results about "Primary alcohol" patented technology

The invention discloses a photosensitive polyimide, a negative photoresist and an application of the photosensitive polyimide in preparation of a film, the structure of the photosensitive polyimide is shown in the specification, X is a tetravalent organic group and is a residue X of a polyimide polymerization monomer tetracarboxylic dianhydride; y is a divalent organic group and is a residue Y of a polyimide polymerization monomer diamine; r1 and R2 are monovalent organic groups and are residues of primary alcohol forming side chain ester bonds of side chain polyamic acid ester; side chains R1 and R2 at least contain tertiary amine structures, and at least one of the side chains R1 and R2 containing the tertiary amine structures can form ammonium salt with phosphate containing an allyl structure; and n is an integer from 2 to 150. The invention provides a photosensitive polyimide which can be developed by adopting an alkaline aqueous solution, can be cured at low temperature and can form a negative pattern, a preparation method of a photoresist composition of the photosensitive polyimide, and a photoetching curing film, which can be applied to display industry or semiconductor industry as an insulating layer, a passivation layer or an interlayer dielectric layer and the like.

The invention provides polyamide acid ester, photosensitive polyimide resin, a negative photoresist composition and application thereof. A covalent bond on a side chain of the polyamic acid ester contains a benzoylmethyl-containing structure, the structure has an ultraviolet light sensing function and can realize light degradation, so that the polyamic acid ester is converted into polyamic acid and primary alcohol, and the formed polyamic acid can be dissolved in a water-based developing agent, so that the targets of water-based developing and photoetching are realized. Besides, after the polyamic acid ester provided by the invention is imidized, no crosslinking component is left, and the polyamic acid ester has high mechanical property, high resolution, high film thickness and depth-to-width ratio gt; and 2.0, good performance can be achieved even if low-temperature curing is carried out.

The present invention relates to the field of photocatalytic alcohol oxidation, and more particularly to a TiO2 / NaBr photocatalytic system for selectively oxidizing primary alcohols to produce acids under mild conditions. The present invention utilizes TiO2 as a primary catalyst and a halide salt as a co-catalyst. In an organic solvent, a primary alcohol raw material is added, and the system is developed in situ under oxygen and blue LED visible light. This photocatalytic system can efficiently complex with primary alcohol compounds. At room temperature, under the pressure of an oxygen balloon, and using ethyl acetate as the reaction solvent, it can oxidize the hydroxyl groups in aromatic and aliphatic primary alcohols to the corresponding acids. This method offers the advantages of good product selectivity, high conversion efficiency, and mild conditions. Furthermore, the catalyst is easily recyclable and the production cost is low. This method is a successful example of the photocatalytic oxidation of the biomass alcohol platform compound n-butanol to n-butyric acid.

The invention relates to a process for obtaining isobutene from an isobutene containing C4-hydrocarbon mixture (1) in a plant comprising an etherification unit (3), a first distillation unit (5), an ether cleavage unit (10) and a second distillation unit (12), the process comprising: (a) contacting the C4-hydrocarbon mixture (1) with a primary alcohol (2) and reacting the mixture with the primary alcohol in the presence of an acidic catalyst to form the corresponding alkyl tert-butyl ether in the etherification unit (3); (b) distilling the reaction mixture (4) from the etherification unit (3) in the first distillation unit (5), a C4-hydrocarbon raffinate being withdrawn as the overhead product (6), and the alkyl tert-butyl ether being withdrawn as the bottom product (7); (c) vaporizing the bottom product from the first distillation unit (5) in an evaporator (8) obtaining a vapor stream (9); (d) reacting the vapor stream (9) of step (c) in the presence of an acidic catalyst obtaining isobutene and the primary alcohol as reaction products in the ether cleavage unit (10); (e) distilling the reaction mixture (11) from the ether cleavage unit (10) in the second distillation unit (12), isobutene being withdrawn as the overhead product (13), the primary alcohol and diisobutene being withdrawn as the bottom product (14) and being recycled to the etherification unit (3); wherein a purge stream (15) containing high boiling components with a normal boiling point higher than that of the alkyl tert-butyl ether is withdrawn from the evaporator (8) in step (c).

The present application relates to the technical field of organic synthesis, and particularly relates to a method for preparing (+)-crispine A by means of biological enzyme resolution. First, 6,7-dimethoxy-3,4-dihydroisoquinoline-2-oxide is subjected to 1,3-dipolar cycloaddition with allyl alcohol to obtain a first compound; then the first compound is added into a sulfonylation reagent and zinc powder to obtain a racemate second compound through a three-step continuous series reaction of primary alcohol sulfonylation, nitrogen-oxygen bond cleavage and ring formation; then the second compound is mixed with vinyl acetate and biological enzyme, and chiral resolution is carried out under the action of the biological enzyme to obtain a third compound with right-handed optical rotation and a fourth compound with left-handed optical rotation; finally, the third compound is mixed with an alkaline reagent and a sulfonylation reagent, and then secondary alcohol sulfonylation is carried out to obtain a fifth compound with right-handed optical rotation; the fifth compound is mixed with a deoxidizing reagent to carry out deoxidation reaction, and (+)-crispine A is prepared. The method is simple, green and environmentally friendly, and can be produced in large quantities.

A process for preparing polyisobutene from isobutene in the presence of a Lewis Acid and an initiator characterised by feeding linear and / or branched C5-C8 primary alcohol, oxidising of the primary a

The application provides a preparation method of MK-0616 south fragment, and relates to the technical field of polypeptide synthesis. The preparation method comprises the following steps: condensation reaction of alkyl primary alcohol 17 and protected amino acid 2 to obtain intermediate 18; deprotection reaction of the intermediate 18 to obtain intermediate 19; condensation reaction of the intermediate 19 and compound 4 to obtain intermediate 20; deprotection reaction of the intermediate 20 to obtain intermediate 21; condensation reaction of the intermediate 21 and compound 10 to obtain intermediate 22; deprotection reaction of the intermediate 22 to obtain intermediate 23; condensation reaction of the intermediate 23 and compound 14 to obtain intermediate 24; hydrolysis reaction of the intermediate 24 to obtain a crude product of MK-0616 south fragment; salt crystallization of the crude product of MK-0616 south fragment to obtain intermediate 15; and free acidization of the intermediate 15 to obtain a pure product of MK-0616 south fragment.

The invention discloses a diamine monomer, a transparent high-temperature-resistant polyester imide film prepared from the diamine monomer and application of the transparent high-temperature-resistant polyester imide film, the diamine monomer is synthesized from 4-aminobenzoic acid and binary primary alcohol or 4-nitrobenzoyl chloride and a phenolic compound, and ester groups with symmetrical structures are introduced into the chemical structure of the monomer, so that the diamine monomer can be synthesized into the transparent high-temperature-resistant polyester imide film. According to the preparation method of the high-temperature-resistant polyester imide film, the polyester imide synthesized with anhydride simultaneously contains imide bonds and ester bonds, so that the correspondingly prepared high-temperature-resistant polyester imide film not only has simple preparation method, but also has excellent optical performance, thermal performance and flexibility, has higher glass transition temperature while keeping higher optical transmittance, and can be used for preparing the high-temperature-resistant polyester imide film. Therefore, the material has good heat resistance and thermal stability, and has good application prospects in the fields of high-temperature-resistant optical films, flexible circuit substrates, lithium battery diaphragm coatings, photoelectric chip substrates and the like.

The invention discloses a phosphabicyclo [3, 2, 0] organic phosphorus compound as well as a preparation method and application thereof. Diallyl-containing tertiary phosphine oxide and phosphine sulfur compounds are used as raw materials, 10-phenyl phenothiazine is used as a photocatalyst, the photocatalyst is excited under a light source of 390 nm to activate double bonds, high-stereoselectivity [2 + 2] cycloaddition reaction is realized, the phosphorus heterocyclic bicyclo [3, 2, 0] organophosphorus compound containing two quaternary carbon centers is synthesized, diastereoisomers can be separated, and the yield is high. A single diastereoisomer product is as high as 97%, and excellent diastereoselectivity is achieved. The invention provides a green reaction mode for photocatalytic synthesis of the phosphabicyclo [3, 2, 0] organophosphorus compound, the conditions are mild, and the substrate universality is good. The obtained phosphabicyclo [3, 2, 0] organophosphorus compound is applied to a primary alcohol chlorination reaction as a catalyst, shows high reaction activity, and has more excellent catalytic activity compared with a reported catalytic system.

This application relates to the technical field of traditional Chinese medicine compositions, specifically disclosing a traditional Chinese medicine composition for treating deficiency syndromes caused by illness, surgery, radiotherapy, and chemotherapy, and its preparation process. The composition comprises Ganoderma lucidum extract and ginseng powder. The preparation method of the Ganoderma lucidum extract is as follows: Step 1, pulverizing the raw material to obtain Ganoderma lucidum powder; Step 2, extraction: extracting the Ganoderma lucidum powder with a primary liquid-liquid phase solvent for 1.5-2.5 hours, adding non-oxidizing gas nano-bubble water and extracting for 0.5-1.5 hours, then adding acidic gas nano-bubble water and continuing extraction for 0.5-1.5 hours; Step 3, collection: collecting the extract, concentrating, forming a paste, and drying to obtain the Ganoderma lucidum extract; the primary liquid-liquid phase solvent includes an alcohol solution with a volume ratio of (2-5):1 and a non-polar organic solvent, with the alcohol volume percentage in the primary alcohol solution being 65-90%. The composition of this application has a higher content of Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenes.

The invention discloses a preparation method of (a / b)-D-fucose and fucose tetraacetate, and belongs to the technical field of organic synthesis. The preparation method of the (a / b)-D-fucose and fucose tetraacetate is based on a PPh3 / NBS method, the PPh3 / NBS combination is a method for efficiently, highly selectively and mildly converting primary alcohol and secondary alcohol into corresponding alkyl bromide, and the core of the method is to generate Ph3PBr2 to activate hydroxyl. In the whole process, reaction conditions are mild, treatment is simple, needed drugs are cheap and easy to obtain, most of intermediate products are synthesized through a one-pot method, few intermediate products need to be separated and purified through silica gel column chromatography, the operation time of follow-up experimental treatment and separation and purification is omitted, and the time of the whole reaction process is greatly shortened. In addition, due to the fact that repeated purification is not needed, the final yield is guaranteed, the total yield can reach 17%, and the gram level can be reached at a time.

This invention provides a method for preparing tert-butyl 2-hydroxymethylbenzoate, the method comprising the following steps: (1) reacting tert-butyl hydrogen phthalate and isobutyl chloroformate to obtain compound 1, (2) reacting compound 1 to obtain tert-butyl 2-hydroxymethylbenzoate; the preparation method provided by this invention has a high yield and stable process, the post-processing is relatively simple, it can avoid operations such as column chromatography, and the reagents used are all conventional reagents, which reduces the production cost and is applicable to industrial scale-up production, providing technical support for the reduction of carboxylic acid compounds into primary alcohols.

This invention discloses carboxymethyl sucrose amino acid salts, their preparation, compositions, and applications. The salts are prepared from carboxymethyl sucrose and arginine, or carboxymethyl sucrose and glycine, through a chemical reaction. The resulting salts undergo a series of processes including primary alcohol precipitation, redissolution, secondary alcohol precipitation, redissolution, tertiary alcohol precipitation, soaking, pulverization, filtration, and drying to obtain carboxymethyl sucrose arginine and carboxymethyl sucrose glycine salts. A composition is prepared by mixing these two salts. Both salts and the composition significantly inhibit the activity of matrix metalloproteinase 1 and promote the expression of type I collagen, thus delaying aging by maintaining the stability of collagen morphology and structure in the extracellular matrix. The preparation method of this invention is simple and the process conditions are mild. The product has the advantages of being weakly acidic, gentle on the skin, highly safe, and having good anti-aging effects. It can be widely used in skin care cosmetics and has promising application prospects.

The present invention relates to the technical field of polyurethane compositions, particularly to a polyurethane composition and a polyurethane composite material, the polyurethane composition comprises an isocyanate component, an isocyanate reactive component, a catalyst and an optional auxiliary agent, the viscosity of the isocyanate reactive component at 25 DEG C is 400-700 mPa.s; the isocyanate reactive component includes: a low viscosity polyol; the viscosity at 25 DEG C is smaller than or equal to 200 mPa.s, the hydroxyl value is larger than or equal to 1000 mgKOH / g, and the primary alcohol is the primary alcohol with the average functionality larger than or equal to 2; the time required for increasing the real-time mixing viscosity eta t of the isocyanate component and the isocyanate reactive component by 100% at 25 DEG C compared with the initial mixing viscosity eta 0 is t, and t is greater than or equal to 200 s and greater than or equal to 660 s. The polyurethane composition disclosed by the invention is applied to a composite material pultrusion process, rapid pultrusion can be realized, the pultrusion efficiency of polyurethane is remarkably improved, and meanwhile, the performance of an obtained composite material is excellent.

The present invention relates to a multi-component resin system comprising (i) at least one resin component (A) comprising at least one curable epoxy resin and (ii) at least one curing agent component (B) comprising at least one primary alcohol and copper (II) tetrafluoroborate. The present invention further relates to the use of such a multi-component resin system for the chemical fastening of construction elements in holes (for example boreholes) or gaps, and the use as an adhesive or as a coating.

This invention provides a method for efficiently producing aliphatic aldehydes by oxidizing aliphatic primary alcohols having four or more carbon atoms. [Solution] A method for producing an aliphatic aldehyde, comprising the step of oxidizing an aliphatic primary alcohol having 4 or more carbon atoms with molecular oxygen in the presence of a ruthenium-supported catalyst, The ruthenium-supported catalyst comprises ruthenium supported on a carrier, The aforementioned support is a porous oxide, The surface area per unit mass of ruthenium is 60 m². 2 / g or more The mesopore volume of the ruthenium-supported catalyst is 0.15 mL / g or more. A method for producing aliphatic aldehydes.

The invention discloses a radix fici simplicissimae polysaccharide extract and a preparation method and application thereof.The radix fici simplicissimae polysaccharide extract is radix fici simplicissimae crude polysaccharide or purified polysaccharide, and the radix fici simplicissimae crude polysaccharide is obtained by conducting primary alcohol precipitation, Sevage method protein removal and secondary alcohol precipitation on a radix fici simplicissimae water extract and then conducting drying; the purified polysaccharide is obtained by performing DEAE-52 fiber column chromatography on RFH, eluting by taking a sodium chloride solution as an eluent, respectively collecting elution parts of 0.3 mol / L sodium chloride solution, 0.4 mol / L sodium chloride solution and 0.5 mol / L sodium chloride solution, and respectively performing dialysis and drying. The radix fici simplicissimae polysaccharide extract prepared through a limited method can effectively activate macrophages to generate immunocompetence and is expected to be used for preparing immunomodulators or related drugs or food for enhancing the immunologic function.

A process for making liquid fuels, especially diesel fuel, from primary alcohols. The process involves subjecting a feedstock comprising primary alcohols to Guerbet coupling to yield a first intermediate mix; subjecting the first intermediate mix to hydrogenolysis to yield a second intermediate mix; and subjecting the second intermediate mix to etherification to yield a liquid fuel suitable for use in internal combustion engines.

The invention discloses a method for oxidizing primary alcohol into carboxylic acid. The invention relates to a method for producing carboxylic acids by oxidizing primary alcohols in the liquid phase in the presence of ruthenium dioxide as catalyst. The method using ruthenium dioxide as a liquid phase catalyst according to the present invention allows the desired carboxylic acid to be obtained with high selectivity, high weight hourly space velocity and thereby good space-time yield, and exhibits high robustness even after a prolonged reaction time.

The present invention relates to process of alkylating a ketone of the formula (I) with an alcohol of the formula (II) having at least one primary and optionally at least one secondary hydroxyl group in the presence of an iron catalyst of the formula (III).

The present application relates to the chemical technology field, specifically to a kind of preparation method of high-purity o-vanillin.The method uses o-methoxyphenylamine as starting material, with chloral hydrate and hydroxylamine hydrochloride is condensed, hydroxylamine oximation reaction, and cyclization reaction is carried out under strong acid condition, and compound 2 is generated;Compound 2 is oxidized under strong base condition, and compound 3 is generated;Compound 3 is esterified with primary alcohol to generate corresponding ester, and then reduction hydrogenation reaction is carried out under the action of strong reducing agent, and compound 4 is generated;Compound 4 is reacted with oxidizing agent in the presence of nitroxyl radical catalyst, and compound 5 is generated;Compound 5 carries out diazotization hydrolysis reaction, and o-vanillin is generated.The method avoids the problem of regioselectivity of traditional formylation reaction through specific reaction sequence, eliminates the generation of isomer impurities from the source, realizes the efficient, environmentally friendly, economic synthesis of high-purity o-vanillin, and provides high-quality raw material guarantee for downstream pharmaceutical.

The invention relates to the technical field of chemical engineering, and discloses a preparation method of alcohol amine with low carbon dioxide emission, which comprises the following steps: step 1, introducing ethanol and ammonia gas into a fixed bed reactor according to a molar ratio of 1: 1.2-1: 1.5, reacting in the presence of a Pd / SO42-ZrO2-SiO2 catalyst to generate a primary alcohol amine intermediate, wherein the catalyst comprises 2.5-3.5 parts by mass of palladium and 96.5-97.5 parts by mass of a ZrO2-SiO2 composite carrier, the molar ratio of Zr to Si is 1: 4, and the content of sulfate radicals on the surface of the carrier is 0.8-1.2 mmol / g; the reaction temperature is 80 to 90 DEG C, and the pressure is 0.5 to 0.6 MPa; 2, introducing a product obtained in the step 1 into a two-stage series adsorption tower system; and step 3, carrying out pressure reduction treatment on the adsorbent at the pressure of-0.09 to-0.10 MPa and the temperature of less than or equal to 40 DEG C, and recovering carbon dioxide. According to the method, a Pd / SO42-ZrO2-SiO2 catalyst system is adopted, so that ethanol and ammonia gas efficiently react to generate a primary alcohol amine intermediate; compared with a traditional catalyst system with the problems of easy carbon deposition and fast activity attenuation, the catalyst has the advantages of higher stability, by-product reduction and target product selectivity improvement.

The present application relates to a bufalin derivative and its preparation method and application, belong to the medical technical field. The present application adopts TEMPO oxidation reaction, and selectively oxidizes the primary alcohol in 19-OH bufalin to aldehyde, successfully synthesizes 19-CHO bufalin, that is, bufalin derivative. The bufalin derivative of the present application has a significant killing effect on pancreatic cancer BxPC-3 cells, liver cancer HepG2 cells and brain glioma U-87MG cells, the IC 50 of the bufalin derivative on BxPC-3 cells is 40.63 nM, the IC 50 of the bufalin derivative on HepG2 cells is 36.74 nM, and the IC 50 of the bufalin derivative on U-87MG cells is 28.73 nM, and the IC 50 of the bufalin derivative on CHO-K1 cells is greater than 30 μM, indicating that the toxicity to the heart is weak, and the bufalin derivative can be applied to the application of anti-pancreatic cancer, anti-liver cancer and anti-brain glioma drugs.

The present application provides a demercaptan agent consisting of: (1) at least one aminocarboxylate salt containing a primary amine group, a secondary amine group or a tertiary amine group, (2) at least one alcohol amine being a primary alcohol amine, a secondary alcohol amine or a tertiary alcohol amine, and (3) water. The present application also provides a preparation method and use of the demercaptan agent and a method for removing mercaptans from liquefied petroleum gas using the demercaptan agent. The demercaptan agent of the present application removes mercaptans by extraction without using inorganic bases such as sodium hydroxide, and the regenerated demercaptan agent can be regenerated by steam stripping, recycled and used, and no alkali residue is discharged. The demercaptan agent of the present application can be used for removing mercaptans from liquefied petroleum gas, and the total sulfur content of refined liquefied petroleum gas can be reduced to 5 μg·g ‑1 The following.

The application discloses a method for preparing a pyrimidine derivative by catalyzing lignin conversion through a rhodium-based catalyst. The method takes real lignin as a substrate, takes amidine hydrochloride and a primary alcohol as reaction raw materials, and utilizes the rhodium-based catalyst to prepare the pyrimidine derivative in an air atmosphere through a one-pot two-step method under alkaline conditions. The method for preparing the pyrimidine derivative from the real lignin is realized, and the method has the advantages of simplicity, high product selectivity, mild reaction conditions and the like.

This invention belongs to the field of organic synthesis technology, specifically relating to a method for synthesizing a carboxyl-containing adamantane methacrylate resin monomer. The synthesis method includes the following steps: S1: 3-hydroxyadamantane-1-carboxylic acid is reacted with concentrated sulfuric acid and a primary alcohol to obtain methyl 3-hydroxyadamantane-1-carboxylic acid; S2: methyl 3-hydroxyadamantane-1-carboxylic acid is esterified in a reaction containing methacryloyl chloride, triethylamine, and dichloromethane to generate methyl 3-methacrylate-adamantane-1-carboxylic acid; S3: methyl 3-methacrylate-adamantane-1-carboxylic acid is subjected to an alkaline hydrolysis reaction in a reaction containing methacryloyl chloride, alkaline solution, water, and a secondary alcohol to obtain a carboxyl-containing adamantane methacrylate resin monomer. This invention solves the technical problems of low esterification conversion rate, large raw material residue, and easy polymerization of the product due to the presence of carboxyl groups in the resin monomer, making industrial-scale production impossible.

The present invention relates to a method for obtaining a recycled polyol (RP) from a polyisocyanurate material (a) wherein the polyisocyanurate material (a) comprises isocyanurate structures wherein the method comprises mixing (a) the polyisocyanurate material, (b) at least one polyalcohol, wherein the polyalcohol (b) has at least two primary alcohol groups and a hydroxyl value of 200 to 800 mg KOH / g, (c) at least one aliphatic monocarboxylic acid, (d) at least one catalyst comprising at least one basic catalyst (d1) catalyzing esterification of alcohol groups and carboxylic acids and (e) optionally at least one deamination agent and reacting the mixture to obtain a recycled polyol having an OH-number of 150 to 300 mg KOH / g, a viscosity of less than 25.000 mPas at 25 °C a and a content of polyisocyanurate material (a), based on the total amount of compounds (a) to (e), of at least 20 % by weight. The invention is further directed to a recycled polyol obtainable according to such a method and a process for the production of a polyisocyanurate rigid foam.

The invention discloses a preparation method and application of a series of novel chiral polydentate amino alcohol ligands. The synthesis method comprises the following steps: preparing primary alcohol type chiral amino alcohol by taking L-amino alcohol and 2-halogenated heteroaromatic ring as raw materials and carrying out nucleophilic substitution reaction in one step; the tertiary alcohol type chiral amino alcohol is prepared by taking L-leucine as a raw material, and sequentially carrying out methyl esterification, Buchwald-Harwig cross-coupling reaction and phenyl magnesium bromide addition reaction to synthesize the tertiary alcohol type chiral amino alcohol. The method disclosed by the invention is simple in process, mild in reaction condition, cheap and easily available in raw materials, easy in product separation and purification and high in yield; and the prepared chiral polydentate amino alcohol ligand can be applied to identification of camphorsulfonic acid enantiomers and determination of enantiomer excess (ee value).

This invention provides a method for producing aliphatic aldehydes in high yield by oxidizing aliphatic primary alcohols having four or more carbon atoms. [Solution] A method for producing an aliphatic aldehyde, comprising the step of oxidizing an aliphatic primary alcohol having 4 or more carbon atoms with molecular oxygen in the presence of an N-oxyl compound and / or an N-oxide compound and a metal-supported catalyst, The metal-supported catalyst includes a metal supported on an inorganic support, A method for producing an aliphatic aldehyde, wherein the N-oxyl compound and / or N-oxide compound is one or more selected from the group consisting of compounds represented by general formula (I), compounds represented by general formula (II), and compounds represented by general formula (III). [Formula 1] JPEG2026104778000025.jpg37124