17 results about "Immunocompetence" patented technology

This invention provides an oyster peptide and its application in enhancing immunity. The oyster peptide has a novel amino acid structure. The oyster peptide can enhance the activity of immune cells, promote the proliferation of immune cells, promote the development and maturation of immune organs, regulate the in vivo immune environment, promote the secretion of immunoglobulins, and improve humoral immunity.

The application discloses a tomato Soly04g076730 Gene or its encoded protein is applied to resisting plant geminivirus. Soly04g076730 The gene is transiently expressed or stably genetically transformed in a plant leaf. When a virus invades the plant, the plant immune response is rapidly induced, and the disease resistance of the plant is improved. The Soly04g076730 protein is a secretory protein. The plant immune ability can be improved by expressing or externally applying the protein in the plant, and the virus transmission and replication can be effectively inhibited.

This invention belongs to the field of microbial technology, specifically relating to a *Clostridium butyricum* strain, its culture conditions, and applications. This invention provides a novel *Clostridium butyricum* strain with strong resistance to high temperatures, acids, alkalis, and salts, exhibiting high biocompatibility and no significant toxic side effects or hemolytic activity. Therefore, the *Clostridium butyricum* H2-2 is a potential probiotic strain that can be used as feed or feed additive in pig, poultry, and aquatic feeds for animal husbandry, strengthening the intestinal barrier and enhancing animal immunity; it also holds promise for use as an additive in human food, pharmaceuticals, and health products.

The application discloses a lactoferrin complex and a preparation method and application thereof. The complex is prepared from raw materials including 5-120 parts of lactoferrin, 0.5-20 parts of propolis extract and 0.1-10 parts of chlorogenic acid. The lactoferrin complex has excellent stability, and the immunocompetence, anti-inflammatory and antioxidant functions are significantly enhanced, so that the lactoferrin complex has wide application prospects in the fields of food, health management and pharmaceutical chemical industry.

This invention discloses a traditional Chinese medicine composition for preventing and treating respiratory viral infections and enhancing the body's immune function, and its preparation method. The composition comprises the following parts by weight of traditional Chinese medicine raw materials: Astragalus membranaceus 90-120 parts, Atractylodes macrocephala (stir-fried with wheat bran) 60-90 parts, Saposhnikovia divaricata 60-90 parts, Citrus reticulata peel 60-90 parts, Bupleurum chinense 60-90 parts, Zingiber officinale (dried) 30-60 parts, Platycodon grandiflorus 60-90 parts, Schisandra chinensis 30-60 parts, Taraxacum mongolicum 90-120 parts, Forsythia suspensa 90-120 parts, Codonopsis pilosula (sliced) 60-90 parts, and Glycyrrhiza uralensis (sliced) 60-90 parts. This invention relates to the field of pharmaceutical technology. This traditional Chinese medicine composition for preventing and treating respiratory viral infections and enhancing the body's immune function, and its preparation method, have diverse therapeutic mechanisms, exhibiting multi-level and multi-target characteristics. It enhances immunity and inhibits H3N2 virus through multiple intervention mechanisms. In clinical practice, this traditional Chinese medicine composition has a positive effect on preventing COVID-19 infection. Practice has proven that this traditional Chinese medicine composition can effectively prevent COVID-19 infection and alleviate symptoms such as fever, cough, fatigue, and sore throat after COVID-19 infection.

The application belongs to the technical field of biological medicine, and particularly relates to a medium-chain fatty acid composition for improving immunity of calves and a preparation method thereof. The medium-chain fatty acid composition for improving immunity of calves according to the application comprises, in terms of weight fractions, 20-30 parts of lactose, 5-10 parts of medium-chain fatty acid, 1-3 parts of mangiferin derivative, 0.5-2 parts of wedelolactone and 0.2-1 part of vitamin C. The mangiferin derivative according to the application can relieve local inflammatory reaction of the intestinal tract, repair the intestinal mucosal barrier damaged by stress, and enhance the non-specific immune capacity of the body. The wedelolactone according to the application forms a double synergy with the lactose and the medium-chain fatty acid, greatly improves the utilization efficiency of energy and nutrients, and thus promotes the growth and development of the calf. In addition, the wedelolactone can also synergize with the mangiferin derivative, maintains the intestinal health of the calf in the early weaning period, and significantly weakens the weaning stress impact.

The application discloses an application of physalin F in prevention and treatment of corn southern leaf blight, and belongs to the technical field of plant disease prevention and treatment. The application aims to break through the limitation of the prior art, and provides a novel prevention and treatment strategy of a small molecule compound physalin F. The strategy can not only directly inhibit spore germination of pathogenic bacteria, but also focuses on stimulating the immune capacity of crops, so as to provide an efficient, safe and novel mechanism solution for sustainable management of corn diseases.

This invention relates to lipid compositions, pancreatic-targeting lipid nanoparticles, their preparation methods, and applications. The lipid composition comprises cationic lipids, cholesterol, phospholipids, and polyethylene glycol-modified lipids; the mass ratio of the cationic lipids, cholesterol, phospholipids, and polyethylene glycol-modified lipids is 16:7-20:4-12:2-4; the cationic lipids are obtained by reacting 3,7-dimethyl-6-octen-1-ylacrylate with polyethyleneimine. The pancreatic-targeting lipid nanoparticles are self-assembled from the lipid composition in an aqueous medium. The lipid nanoparticles of this invention exhibit excellent pancreatic tumor targeting ability, capable of delivering nucleic acid drugs (e.g., IL-12 mRNA) to in situ PDAC and other tumor tissues, significantly enhancing anti-tumor immune capacity, thereby significantly improving their therapeutic efficacy and safety against PDAC and other tumors.

This invention relates to the field of microbial technology, specifically to a Bacillus vesiculus SFKC01 for oil control and acne treatment, its fermentation products, applications, and products. The Bacillus vesiculus (… Bacillus from Velez The preservation number of SFKC01 is CGMCC No. 34956. The preparation method of Bacillus vesiliflorus SFKC01 fermentation product includes mixing Bacillus vesiliflorus SFKC01 bacterial suspension with traditional Chinese medicine extracts to obtain a mixed solution, adding feed culture medium, mixing thoroughly, and then carrying out secondary fermentation to obtain a traditional Chinese medicine fermentation broth. The broth is then filtered to remove the bacterial residue. This fermentation product has multiple effects, including oil control, acne treatment, and anti-inflammatory soothing. It can significantly inhibit the growth of harmful bacteria related to acne, while promoting the reproduction of beneficial bacteria in the skin, regulating the skin's microecological balance, enhancing the skin barrier function and self-immunity, and improving the problem of recurring acne from the source.

This invention relates to the field of aquaculture technology, and in particular to an immune enhancer for juvenile large yellow croaker (Culter alburnus), its preparation method, and its application. The immune enhancer provided by this invention, through the compounding of specific components in a specific ratio, achieves the synergistic effect of polypeptides, immunopolysaccharides, antioxidants, and nutritional factors, while also considering rapid absorption, immune regulation, and high-temperature environmental stability. It is suitable for the immune enhancement needs of large yellow croaker juveniles under high-temperature seawater conditions of 29-31 °C, and can enhance the non-specific and specific immunity of juveniles under high-temperature seawater conditions, improving disease resistance and survival rate.

This invention belongs to the field of animal husbandry and veterinary medicine technology, and discloses the application of rumen-exposed taurine in regulating the production performance and immune capacity of peripartum dairy cows. This invention discovers that rumen-exposed taurine can significantly regulate inflammatory responses, oxidative stress, and energy metabolism-related indicators in peripartum dairy cows, thereby regulating immune function and metabolic balance, effectively improving milk yield, milk quality, and disease resistance. Experimental results show that rumen-exposed taurine can significantly reduce inflammatory responses in peripartum dairy cows, improve energy metabolism, and improve the levels of immune-related factors, thereby reducing the incidence of postpartum diseases and improving production efficiency. This invention reveals a new use of rumen-exposed taurine in the health management of peripartum dairy cows, providing a scientific basis for its development as a feed additive or veterinary preparation, and has broad clinical application prospects.

The present application belongs to the technical field of genetic engineering, and particularly relates to a recombinant plant lactobacillus for preventing and controlling chicken necrotic enteritis as well as a preparation method and application thereof. The present application provides an oral vaccine carrier capable of co-expressing multiple key virulence factor antigens (FimB, NetB, CnaA, FBA) of Clostridium perfringens, and the efficiency of the vaccine carrier being recognized and taken by professional antigen presenting cells is significantly improved through fusion of dendritic cell (DC) targeting molecules (nanobody Phi74), so as to enhance immunogenicity. Immunization of animals using the recombinant lactobacillus can induce mucosal immunity, cellular immunity and humoral immunity response, and comprehensively enhance the immune ability of the body, thereby establishing a safe, efficient and suitable oral immunization scheme for large-scale breeding for treating chicken necrotic enteritis.

The present application relates to application of a T8 synthetic product and its use, (Thr-Lys-Pro-Arg-AAn) 8-(Lys-AAn) 4-(Lys-AAn) 2-Lys-AAn, wherein AA is a natural amino acid peptide chain, and N is a natural number. The branched polypeptide synthetic product has the effect of comprehensively improving the immune capacity of the body, and can be prepared into a therapeutic drug for clinical use in anti-infection and anti-tumor treatment.

The application provides a molecular marker related to an immune trait of sheep and application thereof. The molecular marker is designed according to a primer of a GRB10 gene sequence, DNA is extracted from sheep blood, PCR amplification, DNA sequencing and sequence analysis are carried out, a G / A polymorphic site is found at 119bp of the amplified fragment, further, the polymorphic site of 1086 Hu sheep is detected by using an AQP primer, a least square model is established, genotype and immune traits are associated, and finally it is determined that the G / A polymorphic site at 119bp of the amplified GRB10 gene fragment can be used as the molecular marker related to the immune trait of sheep. By detecting the genotype of the molecular marker, the application can select and keep GG homozygous sheep into a core group for breeding, can be used for improving the immune capacity of sheep, and is helpful to increasing economic benefits.

The present invention provides clinical evidence for a method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring myeloablative conditioning.

The application belongs to the technical field of feed and discloses a kind of mixed feed for enhancing the resistance to Nocardia infection of Lateolabrax japonicus. The application discloses, for the first time, the use of citric acid and / or oregano oil in the preparation of products for preventing or treating diseases caused by Nocardia infection of Lateolabrax japonicus. Experiments show that the addition of citric acid and / or oregano oil to feed can effectively improve the non-specific immune capacity of Lateolabrax japonicus and further improve the survival rate of Lateolabrax japonicus after Nocardia infection. The amount of citric acid and / or oregano oil added is small, and the survival rate of Lateolabrax japonicus after Nocardia infection can be improved by feeding. The addition of citric acid and / or oregano oil does not adversely affect Lateolabrax japonicus, is easy to operate, and has high feasibility.

The application relates to the technical field of vaccine preparation, and discloses an oil-in-water squalene-containing adjuvant as well as a preparation method and application thereof. The adjuvant comprises the following components: squalene, polysorbate 80, sorbitan trioleate, a temperature-sensitive nonionic block copolymer, an amino acid CMT regulator, a polyhydric alcohol CMT regulator, citric acid, sodium citrate, and the rest is injection water. The preparation method comprises the following steps: preparing an oil phase; dissolving the temperature-sensitive nonionic block copolymer, the CMT regulator, the citric acid and the sodium citrate in low-temperature injection water, then pre-treating by temperature rising to obtain an aqueous phase; shearing and emulsifying the aqueous phase and the oil phase at a specific temperature; and finally, controlling the cooling speed of the hot emulsion and filtering. Through the composite formula and the specific process, the long-term storage stability of the adjuvant is remarkably improved, the immunocompetence of the vaccine is guaranteed, the process reproducibility is good, and the production cost is reduced.