24 results about "Immune resistance" patented technology

The present invention relates to compositions (e.g., vaccine compositions) useful for immunizing against Chlamydia infection. These compositions comprise Chlamydia species antigens and antigen combinations that can be used to immunize against Chlamydia species, which antigens and antigen combinations are used in the form of nucleic acids (e.g., mRNA) encoding antigen proteins or in the form of recombinant protein antigens.

This application discloses a method, system, and device for analyzing the state of the tumor microenvironment based on medical images, relating to the field of medical image processing technology. First, by acquiring medical images and gene expression data of related tissues within those images, the medical images are preprocessed to obtain image patches, and semantic features of these patches are extracted. An algorithm is then used to calculate a predefined immune resistance mechanism that matches the gene expression data as the dominant immune resistance mechanism. This dominant immune resistance mechanism is then set as a supervisory label for the model, and a prediction model is constructed. The model is trained using a large amount of data, and the medical image to be analyzed is input into the trained prediction model to obtain the predicted category of the resistance mechanism. This application can accurately predict the resistance mechanism of pathological tissues based on medical images and their related gene expression data.

The invention discloses application of pseudomonas aeruginosa T17 in prevention and treatment of rice bacterial blight. The invention discloses pseudomonas aeruginosa T17 and a function of a fermentation broth thereof as a biological agent in the aspect of disease control. Experiments prove that the pseudomonas aeruginosa T17 can directly inhibit growth of bacterial blight pathogenic bacteria (Xoo) and pyricularia oryzae (M.oryzae). Meanwhile, the fermentation product filtrate can directly induce up-regulated expression of rice defense related genes and up-regulated expression of jasmonic acid (JA) synthesis key genes OsAOS2, and the resistance of rice to bacterial blight can be enhanced by pretreating rice with the fermentation product filtrate. Therefore, the research lays a foundation for taking the pseudomonas aeruginosa T17 and the fermented filtrate thereof as the rice immune resistance inducer, and provides a new thought for developing innovative pollution-free botanical pesticides.

The invention discloses application of zymosan in promoting plant growth and resisting diseases, and belongs to the field of agriculture. The invention provides an application of zymosan in promoting plant growth, wherein the use concentration is 300-800 ppm. After the zymosan is applied, the plant height growth rate of the plant is increased by 10%-25%, and the root system number, the root system length or the leaf area are remarkably increased. The invention also provides a plant growth promoting composition containing the zymosan. The zymosan also has the activity of inducing plant immune resistance. The zymosan disclosed by the invention has dual functions of promoting growth and resisting diseases, is environment-friendly and high in safety, and has a wide application prospect in green agriculture and sustainable agriculture.

The application provides a camellia plant endophytic bacteria, a bacterial agent thereof and an anti-influenza virus A application; the camellia plant endophytic bacteria is Bacillus thuringiensis, which is preserved in the China General Microbiological Culture Collection Center with a preservation number of CGMCC No.32945. The fermentation product of the strain shows good antiviral activity in in vitro and in vivo experiments, can effectively inhibit the replication of influenza virus, and protect infected mice from lethal influenza virus; also shows the effect of regulating immune response, enhances the secretion of IFN-gamma by down-regulating the secretion of pro-inflammatory factors such as IL-6 and IL-10, thereby improving the immune resistance of the body.

The invention relates to the technical field of agricultural biotechnology and plant protection, and discloses application of 2, 4-di-tert-butylphenol nanoemulsion as a plant immune resistance inducer, the 2, 4-di-tert-butylphenol nanoemulsion comprises the following components: 2, 4-di-tert-butylphenol, ethyl acetate, Tween 80 and water, the 2, 4-di-tert-butylphenol, ethyl acetate, Tween 80 and water are added into the 2, 4-di-tert-butylphenol nanoemulsion for the first time, and the 2, 4-di-tert-butylphenol nanoemulsion is added into the plant immune resistance inducer According to the present invention, 2, 4-di-tert-butylphenol is developed into the plant immune resistance inducer, the problems of poor water solubility and low bioavailability of the compound are solved by using the nano-emulsion technology, the brand new application field of the compound is expanded, and the nano-emulsion belongs to a thermodynamic stable system, is not easily layered or precipitated after long-term storage, and has good storage and transportation stability.

The present disclosure provides a natural porphin salt and a use thereof as a plant growth regulator and a plant immunity inducer. The porphin salt includes a salt of porphin or a salt of chlorin. Compared with the prior art, the porphin salt of the present disclosure has high stability, exhibits a stable and reliable quality during long-term storage, has a long shelf life, and is easy to carry and transport. The porphin salt has prominent water solubility, is easy to prepare into an aqueous solution with a stable content, and exhibits excellent reproducibility when applied to the field. The porphin salt can be conveniently applied at a low concentration with a strong activity and a prominent control effect. Raw materials for preparing the porphin salt are natural and widely available. The preparation of the porphin salt is emission-free, pollution-free, energy-saving, and eco-friendly. In particular, when used as a plant immunity inducer, the porphin salt exhibits a significantly better control effect than the existing products.

The invention discloses a plant immune resistance inducer based on yeast beta glucan and melatonin and application, and belongs to the technical field of plant protection. The invention provides a plant immune resistance inducer based on yeast beta glucan and melatonin, the active ingredients of the plant immune resistance inducer are composed of the yeast beta glucan and the melatonin, and the mass ratio of the yeast beta glucan to the melatonin is (300-800): (1-20). It is verified that when the yeast beta glucan and melatonin are combined to serve as the plant immunity resistance inducer, the synergistic interaction effect is achieved in the aspects of inducing plant immunity and promoting plant growth activity.

The invention belongs to the field of preparation and application of oligosaccharide active substances, and provides a biotransformation preparation method of curdlan oligosaccharide and application of the curdlan oligosaccharide in preparation of immune induced resistance products. According to the preparation method, a composite oxidation hydrolysis technology is adopted, food-grade and high-purity raw materials are selected, and the curdlan oligosaccharide with the polymerization degree of 4-10 is successfully prepared through the steps of reagent addition in a specific proportion, strict hydrolysis condition control, concentration, impurity removal, membrane filtration purification and the like. After the oligosaccharide is prepared into a solution, the solution is sprayed on Arabidopsis thaliana leaves, the salicylic acid signal channel of Arabidopsis thaliana can be obviously activated, and the activity of related enzymes in the Arabidopsis thaliana can be improved, so that the immune system of plants is activated, the invasion of pathogenic bacteria is effectively resisted, and the disease index is reduced. Therefore, the curdlan oligosaccharide is an efficient plant immune resistance inducer material. The invention not only provides a new effective substance for the field of plant immune induced resistance, but also develops a corresponding preparation method, and shows a wide application prospect.

The invention provides a trichoderma inoculant, a preparation method thereof and application of the trichoderma inoculant in improving yield and quality of beet, and belongs to the technical field of agricultural microbial inoculants. The trichoderma agent comprises the following components: trichoderma harzianum, trichoderma viride, purpureocillium lilacinum, bacillus amyloliquefaciens and bacillus laterosporus in a mass ratio of (3-5): (1-3): (2-4): (2-4): (1-2). According to the invention, the strains cooperate with each other to promote the growth of beet, effectively enhance the immune resistance of beet, and effectively prevent and reduce beet root rot, brown blotch and other diseases caused by continuous cropping; the photosynthesis efficiency of the beet can be enhanced, the accumulation of photosynthetic products is improved, the soil structure is improved, the number of beneficial bacteria groups in the soil is increased, and the rhizosphere environment is improved, so that the sugar content and yield of the beet are increased. By applying the microbial agent disclosed by the invention, multiple effects of increasing the yield per mu, increasing the sugar content of beet, improving soil, improving the fertilizer efficiency, resisting diseases, preventing insects and the like can be achieved, and farmers are helped to increase both production and income.

The invention discloses a comprehensive cultivation method for preventing and controlling diseases and insect pests of forsythia suspensa, and relates to the technical field of forsythia suspensa planting, and the method comprises the following steps: S1, selecting a land parcel meeting the growth requirements of forsythia suspensa, and completing deep ploughing, fertilization, furrowing and necessary soil disinfection; qualified cutting slips are selected, treated and then subjected to cuttage, and seedlings are cultivated through seedling management; seedlings obtained by seedling raising are transplanted and planted according to specified density in a proper period; performing water and fertilizer management and pruning management to maintain the robust growth state of plants; s2, preparing a composite immune resistance inducer; s3, spraying an immune resistance inducer in a programmed manner; s4, synergistically implementing physical prevention and control and biological prevention and control measures; according to the cultivation method, through scientific site selection and standardized basic cultivation, and programmed spraying of the complex immune resistance inducer in a specific ratio in a key phenological period, the pain points of pathogenic bacteria accumulation, easy waterlogging in summer and the like of continuous cropping plots can be solved in a targeted manner, the stress resistance of forsythia suspensa is effectively improved, leaf diseases and chewing pests are effectively prevented, and the yield is increased.

The invention discloses Pseudomonas sileris Z92-2 capable of improving immune resistance of tobacco bacterial wilt and application of the Pseudomonas sileris Z92-2, the strain is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation address is Beijing, the preservation center number is CGMCC No.35659, the preservation date is August 18, 2025, and the classification name of the strain is Pseudomonas sileris. The strain Z92-2 is an efficient tobacco root colonizing bacterium, and can significantly induce the immunocompetence of tobacco to bacterial wilt. The strain Z92-2 is used as a tobacco bacterial wilt resistant vaccine, is applied by adopting a root irrigation method, can effectively prevent and treat tobacco bacterial wilt, and has a wide application prospect.

The invention relates to the field of plant protection and biological control, in particular to a fungus elicitor STOM and application thereof in plant immunity induction and disease resistance. The invention provides a Ustilaginoidea virens elicitor protein STOM and a coding gene thereof, the elicitor protein is an amino acid as shown in SEQ ID NO: 2, the coding gene STOM is a nucleotide molecule as shown in SEQ ID NO: 1, and the invention further provides the Ustilaginoidea virens elicitor STOM and application of the Ustilaginoidea virens elicitor STOM in induction of plant immunity and disease resistance. Experiments prove that the elicitor protein can significantly activate plant defense reactions, such as active oxygen bursting, defense gene expression and MAPK activation; the disease resistance of the nicotiana benthamiana to diseases such as botrytis cinerea and sclerotinia sclerotiorum can be improved, pathogenic bacterium infection is resisted, and the occurrence of the diseases is effectively prevented or relieved. The elicitor protein provides a new material resource for research and development of protein pesticides / plant immune resistance inducers, provides material and theoretical guidance for compounding of biopesticides, and has a wide application prospect in agricultural production.

The present application belongs to the technical field of raw materials for female and gender external products, and particularly relates to a bionic vaginal fluid with moisturizing and anti-inflammatory effects and a preparation method and application thereof. The bionic vaginal fluid comprises the following components in parts by weight: polysaccharide of Phaeolepiota aurea 0.1-2 parts and succinyl polysaccharide 0.1-1 part. The present application innovatively uses the combination of polysaccharide of Phaeolepiota aurea and succinyl polysaccharide to prepare the bionic vaginal fluid. The two components cooperate and interact with each other, can play a synergistic effect, and can significantly improve the moisturizing property and anti-inflammatory soothing effect of the bionic vaginal fluid, can provide lubrication and good moisturizing feeling for the vagina, and at the same time help maintain the microecological balance in the vagina and improve the immune resistance of the vagina.

The invention belongs to the technical field of pesticides, and particularly relates to a composition containing a plant immune resistance inducer and a chemical bactericide and application of the composition to promotion of disease resistance and yield increase of corn. The disease index of corn southern leaf blight and corn curvularia leaf spot disease treated by the composition is low and is superior to or close to the prevention effect of a conventional chemical agent treatment group (100% color development), and the yield of corn treated by the composition per mu is increased by 9.7% or above and is close to the yield increase value of the conventional chemical agent treatment group (100% color development).

The invention relates to the technical field of health-care wine, in particular to health-care wine capable of resisting aging, enhancing immunity and prolonging life and a preparation process of the health-care wine capable of resisting aging, enhancing immunity and prolonging life, and the health-care wine capable of resisting aging, enhancing immunity and prolonging life is prepared from the following materials in parts by weight: a wine 1000 parts of Baijiu; animal source components: 5-8 parts of zaocys dhumnade, 5-8 parts of agkistrodon halys, 3-5 parts of deer blood powder and 2-4 parts of Chinese turtle shell; the plant source component comprises a tonifying plant source, a harmonizing plant source and an assistant plant source; according to the invention, the tonifying plant source, the harmonizing plant source and the assistant plant source are combined into the plant source component, and the plant source component and the animal source component form an anti-aging, immune and metabolic regulation network, so that the physiological function of a human body is regulated in a multi-channel manner, and the comprehensive health-care effects of resisting aging, enhancing immune resistance and prolonging life are realized.

The invention discloses a bacillus thuringiensis GZYS2 strain for activating tomato immune resistance and application of the bacillus thuringiensis GZYS2 strain. The preservation name of the bacillus thuringiensis GZYS2 strain for activating tomato immune resistance is GZYS2. The preservation date is May 26, 2025; the preservation number is CGMCC (China General Microbiological Culture Collection Center) At present, the research and the application of the bacillus cereus (Neobacillus cereus) GZYS2 strain in the aspects of nematicidal activity and plant immune resistance induction have not been reported yet. The strain has the unique advantages that the strain prevents and treats the tomato root knot nematode disease through two mechanisms of insecticidal activity and tomato immune resistance activation, the prevention and treatment effect is efficient, safety and environmental protection are achieved, the production process is relatively simple, the use cost is low, pesticide residues of agricultural products cannot be caused, drug resistance of the root knot nematode is not likely to be generated, and the strain has a good application prospect in prevention and treatment of the tomato root knot nematode disease. And the method has remarkable environmental friendliness and sustainability.

The application belongs to the technical field of drug co-delivery, and particularly relates to a nano platform based on attenuated bacterial outer membrane vesicles and capable of realizing co-delivery of siRNA and doxorubicin and a preparation method thereof. msbB extraction and purification of OMVs; synthesis of a targeting functional unit DSPE-PEG 2k -Angiopep-2; and finally, a ROS-responsive co-delivery nano platform AO@PTP / 47aD is prepared. The co-delivery nano platform prepared in the application has a small particle size, a uniform morphology and high biological safety, and does not cause obvious damage to various tissues and organs. The co-delivery nano platform can be used as a general platform for gene delivery and also as an immune activator, is suitable for intravenous injection and can completely overcome the immune resistance of glioblastoma.

The invention relates to the technical field of crop molecular biology and molecular breeding, in particular to an HSM1 gene and application thereof in improving wheat growth period related powdery mildew resistance. The HSM1 gene provided by the invention is a powdery mildew-resistant gene explored from wild two-grain wheat, and is transferred into a common wheat variety Yangmai 158 through multiple hybridization and backcross to obtain a BC5F3 disease-resistant family 16-21, and finally the HSM1 gene is obtained. Results of the specific embodiment of the invention show that a strain with increased expression quantity of the HSM1 gene shows growth period dependent powdery mildew resistance, that is, the plant does not resist diseases in a seedling stage, but the resistance is enhanced after an elongation stage, and high resistance even immune resistance is achieved in a heading stage. The resistance mode provided by the HSM1 gene is beneficial for reducing the energy consumption caused by the expression of the anti-disease gene of the plant, and is beneficial for realizing the high-yield target.

The invention discloses an application of an NLR receptor RCSP (GenBank: XAX32969.1) in endowing or enhancing immune resistance of plants, and the over-expression of the RCSP in the plants can activate ETI and generate very strong systemic resistance, so that the plants can better resist various pathogenic bacteria or viruses and the like.

The invention provides application of vitamin K1 as an immune resistance inducer in crop disease control, belongs to the technical field of agriculture, and finds that the vitamin K1 can improve the disease resistance of crops (rice, wheat and potatoes) to bacteria, fungi, oomycetes and the like. The vitamin K1 is used for treating rice, wheat and potatoes by spraying a vitamin K1 solution with a certain concentration, the disease resistance of the crops to bacteria, fungi, oomycetes and the like can be improved, and the research proves that the vitamin K1 can be used for improving the disease-resistant quality of the crops in the agricultural field.

The invention discloses a nutrient solution for preventing tomato phytotoxicity and preparation thereof, and belongs to the technical field of agricultural fertilizers. The nutrient solution for preventing tomato phytotoxicity is prepared from the following raw materials in parts by mass: 10 to 15 parts of urea, 10 to 20 parts of ammonium nitrate, 10 to 15 parts of potassium fulvate, 5 to 10 parts of potassium nitrate, 10 to 15 parts of calcium superphosphate, 25 to 35 parts of arabidopsis thaliana extract, 1 to 5 parts of EDTA (Ethylene Diamine Tetraacetic Acid) manganese chelate, 1 to 5 parts of EDTA iron chelate, 5 to 10 parts of compound amino acid, 5 to 10 parts of magnesium sulfate, 10 to 15 parts of calcium nitrate, 1 to 3 parts of copper sulfate and 200 to 300 parts of water. After the nutrient solution for preventing tomato phytotoxicity is added, the growth state of plants can be adjusted, and the immune resistance of the plants is induced, so that the tolerance of tomatoes to pesticides is enhanced. Moreover, the nutrient solution has the capability of resisting broad-spectrum phytotoxicity, and has a prevention effect on various types of phytotoxicity.

Described herein are recombinant Newcastle disease viruses ("NDVs") comprising a packaged genome, wherein the packaged genome comprises a transgene comprising a nucleotide sequence encoding a protein comprising a SARS-CoV-2 Omicron variant spike protein or portion thereof, or a derivative thereof. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises a SARS-CoV-2 Omicron variant spike protein ectodomain or a derivative thereof, and NDV F protein transmembrane and cytoplasmic domains. Further, described herein are immunogenic compositions comprising a recombinant NDV(s). The recombinant NDVs and immunogenic compositions are useful for the immunizing against SARS-CoV-2 as well as the prevention of COVID-19.

The invention discloses application of N-lauroyl isoleucine to improvement of resistance to rice sheath blight disease, and relates to the technical field of plant immune resistance inducers and green agricultural invests.It is found for the first time that after plants are treated with low-concentration N-lauroyl isoleucine, systematic resistance of rice to the sheath blight disease can be induced by activating an OsNPR1-OsPR2-OsMAPK6 pathway, and therefore the N-lauroyl isoleucine can be used for improving the resistance of the rice sheath blight disease. The N-lauroyl isoleucine can be used as an effective component of a plant immune resistance inducer. The plant immune resistance inducer prepared by taking the N-lauroyl isoleucine as an effective component can be used for preventing and treating through a spraying method, is high in operability, simple and quick, and can be used for effectively preventing and treating the expansion and spreading of diseases. In addition, the N-lauroyl isoleucine is a biological endogenous metabolite, is easy to degrade and has no residual risk; and the N-lauroyl isoleucine is low in cost and conforms to the current agricultural sustainable development direction.