The invention relates to a novel intermediate di(disubstituted) phenyl dihalogenated porphin derivative which is stable in performance, good in hydrophilicity and not prone to aggregation and an application thereof. The compound has the following structures (I) and (II), wherein X is Cl, Br or I; A and Y are the same or different and are independently CH2 or O; R1 and R2 are different, R3 and R4 are the same or different, at least one of R3 and R4 contains a polar group, and R3 and R4 are independently alkyl groups, alkyl groups containing N or O atoms, alkyl groups containing carbonyl groups or alkyl groups containing amido bonds or alkyl carboxylic acid, alkyl alcohol, alkyl carboxylic acid containing N or O atoms, alkyl alcohol containing N or O atoms, alkyl carboxylic acid containing carbonyl groups, alkyl alcohol containing carbonyl groups, alkyl carboxylic acid containing amido bonds, and alkyl carboxylic acid containing carbonyl groups and amido bonds at the same time. The prepared intermediate dihalogenated diphenyl porphin photosensitizer has remarkable photodynamic activity, and can be used as a drug for photodynamic diagnosis and treatment of diseases such as tumors, retina macular degeneration, actinic keratosis, nevus flammeus and condyloma acuminata.