6 results about "Peganum harmala" patented technology

The invention belongs to the technical field of medicinal chemistry, and particularly relates to an alkaloid compound as a novel topoisomerase I inhibitor and a preparation method and application thereof. The alkaloid compound with a brand new structure is separated from the traditional Chinese medicine peganum harmala. Researches show that the alkaloid compound has very significant topoisomerase I inhibitory activity, and the topoisomerase I inhibitory activity is stronger than that of a positive drug camptothecin. The topoisomerase I plays a key role in DNA replication and division of tumor cells, so that proliferation of cancer cells can be blocked by inhibiting the topoisomerase I. Therefore, when the compound is used as an effective component for preparing the anti-cancer drug, a new material basis can be provided for drug research and development, the curative effect is improved, and side effects are reduced; the compound can also be used as a lead compound, high-activity anti-cancer molecules are derived through structural optimization, and the compound has important application value in the field of cancer treatment.

The invention discloses a traditional Chinese medicine composition for treating thyroid nodules and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The Uygur medicine honey ointment aims at solving the problem that safe and effective Uygur medicine honey ointment for treating thyroid nodules is lacked in the prior art. The traditional Chinese medicine composition comprises the following components in parts by weight: 5-15 parts of bungarus parvus, 5-15 parts of peganum harmala, 5-15 parts of capparis spinosa root bark, 10-20 parts of galangal, 10-20 parts of dried ginger, 5-15 parts of fructus piperis longi and 5-15 parts of cinnamon. The traditional Chinese medicine composition is prepared into the Uygur medicine honey ointment, and natural medicinal materials with homology of medicine and food are selected and are safe and free of toxic and side effects; through reasonable compatibility and synergistic interaction of a plurality of medicinal materials, the traditional Chinese medicine composition has remarkable effects of removing abnormal spleen fluid and qi, eliminating stagnation, expelling wind and removing cold, and resisting tumors; the traditional Chinese medicine composition not only can be used for treating thyroid nodules, but also can be used for treating gland nodular diseases caused by dry cold such as breast nodules and benign prostatic hyperplasia, and can effectively relieve clinical symptoms of patients; the preparation method is simple and convenient to operate, easy to popularize, suitable for industrial production and worthy of popularization and application.

The application provides a peeling method of blueberry kernels, which comprises the following steps: first, soaking dry blueberry kernels in acid with a preset concentration at a preset mass ratio, and continuously stirring; then, peeling the soaked blueberry kernels by using a peeling machine to obtain peeled blueberry kernels; finally, drying the obtained peeled blueberry kernels to obtain finished products. The application utilizes the interaction of lemon acid soaking, combined flushing of normal pressure and high pressure, and low-temperature baking, forms a gap between the blueberry kernels and the peel, realizes efficient peeling by using the combined flushing mode of normal pressure and high pressure, and finally, low-temperature drying, which not only avoids the heat damage of high temperature to the blueberry kernels, but also adapts to different specifications of blueberries, and the obtained blueberry products not only have a high peeling rate, but also have a good taste and a high nutritional value; meanwhile, the color of the obtained finished products is uniform, only a small amount of color is mixed, thereby improving the application of the blueberries in various mixed nutritional products or solid beverages.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and traditional Chinese medicine ointment for preventing and / or treating knee osteoarthritis as well as a preparation method and application thereof. The peganum harmala is used as a monarch drug to dispel wind and eliminate dampness, promote blood circulation to arrest pain and relax tendons and activate collaterals; safflower, frankincense and myrrh are used as ministerial drugs for promoting blood circulation to remove blood stasis and stimulating menstrual flow to relieve pain; cortex phellodendri, radix saposhnikoviae and radix achyranthis bidentatae are used as adjuvant drugs to tonify liver and kidney, strengthen muscles and bones, eliminate dampness and treat warm dryness; and the lycopodium clavatum and the garden balsam stem are used as conductant drugs and directly reach the disease site, so that the effect of dredging the bones and tendons of the whole formula is enhanced. The components of the traditional Chinese medicine raw materials have a synergistic effect, the self-repairing capability of human bodies, tissues and organs is enhanced, patients with knee osteoarthritis are gradually recovered, and the traditional Chinese medicine composition has a good curative effect on knee osteoarthritis prevention and treatment and has the advantages of high efficiency, low toxicity, no drug resistance and wide application range. The traditional Chinese medicine composition provided by the invention is prepared into ointment, so that the defects that decoction and use are inconvenient and some rare medicinal materials are wasted are overcome, and the traditional Chinese medicine composition is easy to act.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to application of an alkaloid compound in preparation of a product with a respiratory syncytial virus resisting effect. The alkaloid compound with a brand new chemical structure is extracted from peganum harmala, the compound shows very remarkable respiratory syncytial virus resistance activity, and the activity intensity of the compound is equivalent to that of a positive drug ribavirin. Meanwhile, the selection index (SI value) of the compound is greater than 13.8, which indicates that the safety range of the compound is larger, and the use safety can be better guaranteed while the drug effect is exerted. Therefore, the compound serving as an active ingredient is used for preparing medicines or health-care products with the effect of resisting the respiratory syncytial virus, and has important application value and wide development prospect.

The present application relates to the technical field of biological medicine, and particularly relates to a composition taking GLP-1 receptor as a target point, which comprises the following raw materials in parts by weight: gentiana scabra extract 10-25 parts, andrographolide sulfonate 5-15 parts, peganum harmala alkaloid 3-7 parts, curcumin functional compound 20-40 parts, and excipients; the excipients comprise sodium caprate 4-8 parts and konjac glucomannan 8-15 parts. The composition of the present application realizes the ordered synergistic effect in time and space through the triple mechanism of "promoting endogenous GLP-1 secretion at the intestinal end, directly activating GLP-1R at the receptor end and prolonging the half-life, and promoting beta cell regeneration and protection at the effector organ end", reshapes the steady-state regulation ability of the body's own GLP-1 signal axis, improves sugar metabolism, and is suitable for the prevention and treatment of diabetes, obesity and related metabolic diseases.