70 results about "Harmine" patented technology

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.

This invention relates to compounds of general formula (I), wherein R1, R2, R3, R4 and R5 are as defined in the specification; intermediates used in their preparation, preparation processes and use thereof. The present invention produces new harmine derivatives with enhanced antitumor activity and lower nervous system toxicity by structurally modification of the parent structure of β-carboline of harmines at position 1, 2, 3, 7 and 9. The compounds of the present invention can be prepared easily with high yield. They can be used in manufacture of a variety of antitumor medicines and medicines used in treatment of tumor diseases in combination of light or radiation therapy.

The invention discloses a method for extracting peganum harmala alkaloid under microwave assistance. The method comprises the following steps: drying a peganum harmala plant to a constant weight, using ethanol with volume concentration of 60-95% as a solvent, extracting for 8-12 minutes under microwave heating assistance at a solid-liquid ratio of 10-50 ml / g and an extracting temperature of 60-100 DEG C, filtering to obtain an extracting solution, concentrating the extracting solution until no alcohol smell exists, coating the extracting solution on a preparative high performance liquid chromatography C18 reverse phase silica gel column, using 0.1 mol / L of ammonium acetate buffer salt solution and acetonitrile with a volume ratio of 70:30 to 96:4 as an elution phase, separating and preparing at a flow speed of 1.0 mL / min and within a temperature range of 20-40 DEG C, online monitoring via ultraviolet 280 nm, collecting eluant with a specific absorption peak, and volatilizing to obtain the following three alkaloids: vasicine, banisterine and harmine. The method is simple, convenient, feasible and controllable, and the yield of the alkaloid of the method is higher than that of the existing extraction methods.

A derivative of β-carboline alkaloid harmine, 10,12-diheptanoyl-11-hydroxy-3-methyl-β-carboline, prepared by a Friedel-Crafts acylation of harmine is reported as a novel potent antitubercular drug.

The invention discloses a method for analyzing an active component in harmel grass. The method comprises the following steps of: constructing a finger print, analyzing the active component in a qualitative manner through the finger print, detecting the content of the active component through an HPLC (high performance liquid chromatography) method, wherein the finger print comprises a TLC (thin-layer chromatography) finger print and / or HPLC finger print. According to the invention, the constructed finger print has excellent reproducibility and specificity, and has good stability, precision and application sample recovery ratio on the content detection method of the active component, can realize qualitative and quantitative analysis of various active components such as vasicine, peganine, harmine, deacetylation harmel glycoside and harmel glycoside in the harmel grass, can fully evaluate the quality of the harmel grass, and can provide scientific reference for medicinal value of research and development on harmel grass; and the analyzing method provided by the invention has the advantages of simplicity in operation, velocity, economy, strong operability and the like, and can carry out popularization and application.