The invention discloses a method of controlling harms of mikania micrantha by allelopathy of local plants. The method comprises steps: after invasive plants in a forest land are removed, the seedlingsof local plants are planted in a mixed mode, wherein the local plants are heteropanax fragrans, macaranga tanarius or aleurites Montana, the seedlings have heights of 50 to 80 cm, and the mixed planting mode is interplanting. The method of the invention has low requirements for tree seedlings, the cost is low, the survival rate is high, the operation is simple and feasible, and the applicabilityis high; through mixed planting, the invasive alien plant Mikania micrantha can be extremely effectively controlled, recurrence is prevented, the invasion harms of other invasive alien plants can alsobe prevented, prevention and control on mikania micrantha in the whole forest community can be realized, and the effects of comprehensive prevention and control can be realized; and the vegetation restoration efficiency is high, and the method disclosed in the invention can be promoted and applied in a large area and has important and far-reaching significance for sustainable development of forests in South China.