The invention relates to a cultivation method of good-quality high-yield Platycodon grandiflorum. The cultivation method comprises the steps of selecting a suitable field, seeding scientifically, transplanting reasonably, managing the field reasonably, controlling pests, harvesting, processing, and reversing seed stocks scientifically. A suite of measures of soaking seed through Chinese herb medicine liquid, cultivating seedlings in summer, transplanting in winter, cutting the seedlings in early summer and the like are adopted, quality of the Platycodon grandiflorum is improved, a commodity stripe selection rate is improved, a yield is increased, and economic benefits are improved. During fertilization, organic fertilizer is adopted as main fertilizer, Chinese herb medicine fertilizer is added at the same time, and the cultivation method is green and environment-friendly. In pest control, pesticide with low concentration and little toxicity is adopted, Chinese herb medicine agents are matched simultaneously, pesticide residue is lowered effectively, content of heavy metal of obtained Platycodon grandiflorum finished products is lowered by more than 50% compared with a conventional method, good demonstration effect is achieved, and the cultivation method passes good agriculture practice (GAP) authentication of the national certification and accreditation administration.