6 results about "Trichloroacetic acid" patented technology

This invention belongs to the field of recycling and purification technology, specifically relating to a method for recovering the β isomer from a CME solution containing both β and α isomers. The method includes the following steps: concentrating the CME solution containing both β and α isomers and dissolving it in methanol with trichloroacetic acid to form a salt, followed by cooling and crystallization and filtration to obtain the trichloroacetic acid salt of the CME β isomer; then, ionizing the trichloroacetic acid salt of the CME β isomer in methanol with ammonia to obtain the CME β isomer. By reacting trichloroacetic acid with the α and β isomers of CME to form a salt, the different solubilities of the trichloroacetic acid salts of the α and β isomers are utilized to separate the trichloroacetic acid salt of the CME β isomer, and then ionizing the trichloroacetic acid salt of the CME β isomer with ammonia, the CME β isomer is recovered.

Topical formulations comprising peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid or acetic acid and hydrogen peroxide are useful for promoting hair growth and for preventing hair loss.

The present application relates to the technical field of determination of nifursol metabolite content, and particularly relates to a method for determining the residual amount of nifursol metabolite in royal jelly. The method comprises the following steps: the royal jelly sample is sequentially subjected to trichloroacetic acid hydrolysis, o-nitrobenzaldehyde derivatization and ethyl acetate purification, and is treated with acetonitrile aqueous solution to constant volume, the pretreated sample is subjected to gradient elution using 5 mmol / L ammonium acetate aqueous solution-acetonitrile as a mobile phase, and is determined by liquid chromatography-tandem mass spectrometry, and the isotopic internal standard method is used for qualitative and quantitative analysis during determination. The royal jelly sample is hydrolyzed using a trichloroacetic acid solution before derivatization treatment, so that the to-be-measured component is well separated from the sample matrix, the matrix influence is reduced, and then the liquid chromatography-tandem mass spectrometry analysis is performed in combination with the selection of the mobile phase and the isotopic internal standard method, thereby improving the qualitative and quantitative accuracy of the residual amount of nifursol metabolite in royal jelly.

Provided is the large-scale preparation of a high-purity hydrolyzed colanic acid or a salt thereof. The method comprises: 1) adding a solution containing a colanic acid or a salt thereof to a colanic acid degradation enzyme comprising an amino acid sequence as shown in SEQ ID NO: 1 or having at least 90% sequence identity thereto; and 2) performing an enzyme termination reaction, wherein the termination in step 2) is achieved by means of a termination agent, a boiling water bath and / or an ice bath, wherein the termination agent is selected from one or more of activated carbon, absolute ethanol, methanol, EDTA, trichloroacetic acid and sodium carbonate, and preferably, activated carbon is used to achieve the termination in step 2), so as to obtain the hydrolyzed colanic acid or a salt thereof. The molecular structure of the hydrolyzed sodium colanate prepared by the provided method features acetylation and pyruvic acid modification. Moreover, the preparation conditions are mild, the production cost is low, continuous production can be achieved, and industrial scale-up is easily implemented. The prepared hydrolyzed sodium colanate has the characteristics of high purity and low endotoxin residue, and has potential and broad application value in fields such as cosmetics, medical devices, and oligosaccharide drugs.

This invention belongs to the field of pathological testing and tissue specimen preservation technology, and in particular, it is a compound solvent-based tissue fixative, which is made by mixing the following raw materials in weight percentages: the main solvent is a 60%-80% ethanol solution; the co-solvent and penetrant is 5%-10% polyethylene glycol tetrahydric acid and 3%-8% diethylene glycol; the dehydrating and hardening regulator is 5%-10% acetone; the pH adjuster and protein precipitant is a 2%-5% glacial acetic acid and 1%-3% trichloroacetic acid solution; the antibacterial and antistatic agent is a 0.5%-2% quaternary ammonium salt solution, wherein the quaternary ammonium salt solution is a 1% octyldecyl dimethyl ammonium chloride solution; and the stabilizer is 1%-3% methoxy-3-methylbutanol. This invention significantly reduces the health risks to operators by eliminating toxic reagents such as formaldehyde and glutaraldehyde and using food-grade ethanol as the main solvent, thus meeting green and environmentally friendly requirements. This characteristic enables the fixative to provide safer working conditions in environments such as pathology laboratories where long-term contact with fixatives is required, thus protecting the health of operators.

The application discloses a method for electrocatalytic hydrogenation dehalogenation of haloacetic acid in water by using a ruthenium / nickel hydroxide catalyst, wherein a conductive material with a surface modified ruthenium / nickel hydroxide is used as a catalytic cathode, the cathode potential is-0.3~‑1.0 V vs. silver / silver chloride reference electrode, and water is used as a hydrogen source, so that the haloacetic acid in water is electrochemically hydrogenated and dehalogenated into acetic acid. Under the condition of the same Ru loading, the catalytic activity of Ru / Ni(OH)2 is higher, the conversion rate of trichloroacetic acid is 9% higher, the acetic acid yield is 14% higher, and the acetic acid selectivity is 5% higher.