43 results about "Trichloroacetic acid" patented technology

The disclosure relates to a method of producing a multi-metal catalyst film and of producing a reactor system for catalytic removal of a wide variety of contaminants (for example, nitrate, nitrite, perchlorate, chlorate, chromate, selenate, chlorophenols, 2,4-D, dicamba, atrazine, trichloroacetic acid, bromochloroiodomethane, NDMA, TCE, TCA, chloroform, freons, RDX, HMX, TNT, PFOA, and PFOS) from water and wastewater. The disclosure also relates to a method of using the multi-metal catalyst for the removal of such contaminants and a system comprising the multi-metal catalyst film for removing such contaminants.

The invention relates to a non-noble metal-based paired electro-catalysis method for producing formic acid by coupling cathode dehalogenation with anode formaldehyde oxidation, which realizes efficient dehalogenation removal of pollutants and generation of high-value products. The Co-CuxO nanowire electrode with excellent catalytic performance is synthesized through a simple method and serves as a cathode and an anode at the same time, and the purpose that the cathode removes halogenated pollutants and the anode oxidizes formaldehyde to produce formic acid at the same time is achieved. Co-CuxO promotes generation of H *, the performance of electroreduction dehalogenation is improved, and the removal rate of trichloroacetic acid can reach 92.1% or above. And moreover, the reaction energy barrier is reduced, the selectivity of formic acid generated by oxidizing anode formaldehyde is improved, and the formic acid selectivity and Faraday efficiency can reach 100%. A paired electro-catalysis system shows extremely stable and outstanding electro-catalysis performance in the aspect of converting wastes into value-added products, and the problems of poor anode utilization rate and high energy consumption in the current electro-catalysis dehalogenation reaction are solved.

The invention belongs to the technical field of environmental engineering, and particularly relates to a rapid prediction method for trichloroacetic acid generation potential in a water disinfection process. The rapid prediction method for the trichloroacetic acid generation potential in the water disinfection process comprises the following steps: constructing a training set and a test set which respectively and independently comprise a plurality of organic compounds and trichloroacetic acid generation potential values and key molecular characteristic parameters corresponding to each organic compound; an extreme gradient lifting machine learning algorithm is adopted to construct a trichloroacetic acid generation potential prediction model, and model precision verification is carried out; optimizing by adopting a Bayesian optimization algorithm to obtain a trichloroacetic acid generation potential optimal prediction model; and inputting the key molecular characteristic parameters of the target compound into the optimal prediction model to obtain the trichloroacetic acid generation potential value of the target compound. The rapid prediction method provided by the invention realizes rapid prediction of the TCAAFP value of the organic compound in the chlorine disinfection reaction, and has the advantages of convenient operation, low cost, strong stability and wide application range.

The invention belongs to the technical field of compound preparation, and particularly provides a preparation method of L-glutamic acid-1-tert-butyl ester, which comprises the following steps: step S1, carrying out imidization reaction on an L-glutamic acid-5-methyl ester compound and benzophenone imine to generate N-dibenzylidene-L-glutamic acid-5-methyl ester; step S2, enabling the N-dibenzylidene-L-glutamic acid-5-methyl ester and tertiary butyl-2, 2, 2-trichloroacetic acid imine ester to be subjected to a tert-butyl esterification reaction, so as to generate N-dibenzylidene-L-glutamic acid-5-methyl ester-1-tert-butyl ester, and enabling the N-dibenzylidene-L-glutamic acid-5-methyl ester-1-tert-butyl ester to be subjected to a tert-butyl esterification reaction; and S3, carrying out hydrolysis reaction on the N-dibenzylidene-L-glutamic acid-5-methyl ester-1-tert-butyl ester to remove a methyl ester group, and removing a protecting group on an amino group, so as to generate the L-glutamic acid-1-tert-butyl ester. The preparation method disclosed by the embodiment of the invention is used for preparing the L-glutamic acid-5-methyl ester-1-tert-butyl ester from the N-dibenzylidene-L-glutamic acid-5-methyl ester-1-tert-butyl ester. According to the application, the tertiary butyl-2, 2, 2-trichloroacetic acid imine ester is used for carrying out the tert-butyl esterification reaction, so that the yield is high, the reaction condition is mild, the post-treatment is simple, the control on the generation of glutamic acid, pyroglutamic acid and pyroglutamic acid tert-butyl ester is facilitated, and the impurities are few.

This invention belongs to the field of recycling and purification technology, specifically relating to a method for recovering the β isomer from a CME solution containing both β and α isomers. The method includes the following steps: concentrating the CME solution containing both β and α isomers and dissolving it in methanol with trichloroacetic acid to form a salt, followed by cooling and crystallization and filtration to obtain the trichloroacetic acid salt of the CME β isomer; then, ionizing the trichloroacetic acid salt of the CME β isomer in methanol with ammonia to obtain the CME β isomer. By reacting trichloroacetic acid with the α and β isomers of CME to form a salt, the different solubilities of the trichloroacetic acid salts of the α and β isomers are utilized to separate the trichloroacetic acid salt of the CME β isomer, and then ionizing the trichloroacetic acid salt of the CME β isomer with ammonia, the CME β isomer is recovered.

The invention relates to a method for improving antioxidant activity of pine pollen polysaccharide by utilizing bifidobacterium fermentation, which comprises the following steps: S1, adding bifidobacterium liquid into pine pollen for fermentation to obtain a fermentation product; s2, adjusting the pH value of the fermentation product in the step S1 to be acidic, and adding protease for enzymolysis to obtain an enzymolysis product; s3, carrying out flash extraction on the enzymolysis product obtained in the step S2, and centrifuging to take supernate, so as to obtain a pollen pini crude polysaccharide extracting solution; and S4, adding a trichloroacetic acid solution into the pollen pini crude polysaccharide extracting solution obtained in the step S3, and dialyzing to obtain the pollen pini polysaccharide with improved antioxidant activity. Compared with the prior art, the pine pollen polysaccharide obtained through fermentation of bifidobacteria can obviously improve the antioxidant activity, improve the development and utilization value of pine pollen and improve the application and market competitiveness of the pine pollen polysaccharide in multiple fields compared with the pine pollen polysaccharide obtained through unfermented pine pollen polysaccharide.

The application relates to the technical field of biological detection, and particularly relates to a sample processing liquid and application thereof in ELISA detection of milk and milk products. The sample processing liquid comprises the following components in percentage by weight: 2-3% of ethylenediaminetetraacetic acid disodium salt dihydrate; 0.075-0.125% of trichloroacetic acid; 10-30% of methanol; and the balance is ultrapure water; and the sample is milk and milk products. The sample processing liquid provided by the application can efficiently and conveniently reduce the matrix interference of milk and milk products in ELISA detection, so that the accuracy, precision and recovery rate of detection can be significantly improved.

The invention provides a method for simultaneously detecting dichloroacetic acid and trichloroacetic acid in urine, and belongs to the technical field of analysis detection and occupational health / environmental health. According to the method disclosed by the invention, a synergistic pretreatment strategy of acidic sample loading, WAX / reversed-phase mixed mode solid-phase extraction, water / low-proportion organic phase step-by-step leaching and ammonia-water-containing organic phase elution is adopted; a technical route of protein precipitation, acidification pH regulation, purification and enrichment by adopting WAX / reversed-phase mixed mode solid-phase extraction on a 96-well plate and stable isotope internal standard isotope dilution LC-MS / MS quantification is adopted, the method can effectively reduce the matrix effect and realize high-throughput analysis in a high-salinity urine matrix, the quantitation limits of DCEA and TCAA are not higher than 0.30 g / L and 0.20 g / L respectively, and the method has the advantages that the method is simple and convenient to operate, and the method is suitable for large-scale popularization and application. The method is suitable for biological monitoring and risk assessment of occupational and environmental low-level exposure crowds.

The invention relates to the technical field of food detection, discloses an efficient detection method for six sugar alcohol compounds in dairy products, and aims to solve the problems that in the prior art, dairy product protein precipitation and high-efficiency dissolution of strong-polarity sugar alcohol are difficult to consider at the same time, and toxic precipitants, high-temperature treatment or complex solid-phase extraction are often depended on. The problems of tedious operation, high equipment threshold and poor detection stability exist in the prior art, trichloroacetic acid with optimized concentration is used for constructing a water phase system, and dissolution of six sugar alcohols and preliminary precipitation of protein are synchronously realized; the high-protein matrix of the milk powder is supplemented with precise supplementary precipitation, and the liquid milk is simplified; a specific chromatographic column and gradient elution are combined, linear correlation is established by adopting an external standard method, synchronous detection of six sugar alcohols is completed, high-temperature and solid-phase extraction consumables are not needed, two matrixes of milk powder and liquid milk are adapted, the operation time is short, the detection recovery rate is high, the precision is excellent, the existing pain point is effectively solved, and the batch detection requirement of a conventional laboratory is met.

The invention discloses a deuterated acetic acid and deuterated acetyl compound high-efficiency electrosynthesis method taking D2O as a deuterium source, and the deuterated acetic acid high-efficiency electrosynthesis method comprises the following steps: in a standard three-electrode double-chamber electrolysis system, taking deuterium water as the deuterium source, adding an electrolyte and a surfactant, and reducing trichloroacetic acid through a constant current electrolysis method to obtain deuterated acetic acid; wherein the monometal electrode for in-situ growth of the nanorod is a working electrode in the standard three electrodes. The method is high in conversion rate and selectivity, is an efficient synthesis method, takes cheap deuterium water as a deuterium source, is mild in reaction condition, does not need high temperature and high pressure, is simple to operate, is easy to separate a product, and can be used repeatedly, and a green, safe and efficient method is provided for synthesis of deuterated acetyl drugs.

The application provides a catalytic cracking propylene-yield catalyst, a preparation method and application thereof, and the preparation method comprises the following steps: reacting ZSM-5 molecular sieve, trichloroacetic acid and tetraethyl orthosilicate in water to obtain a modified intermediate; mixing the modified intermediate, a soluble salt of modified metal and triazemaine in a composite solvent, filtering, taking a solid sample and roasting to obtain a metal-modified molecular sieve; mixing the metal-modified molecular sieve, Y-type molecular sieve, clay and a binder in water to obtain a slurry, spray-drying the slurry to form a solid particle, and roasting again to obtain the catalytic cracking propylene-yield catalyst. After modification of the key component ZSM-5 molecular sieve in the catalyst, the propylene-yield catalyst has a higher mass transfer rate, the metal is uniformly deposited on the molecular sieve, the metal utilization rate and the catalytic cracking reaction performance are improved, the propylene yield in the catalytic cracking product is improved, and the coke selectivity is reduced.

The application relates to an indole derivative obtained by converting quinoline nitrogen-oxide and a synthesis method of the indole derivative, the chemical structural formula of the derivative is shown as formula 2; the synthesis method is as follows: quinoline nitrogen-oxide, dimethyl acetylene dicarboxylate and water are used as reaction raw materials and are added into 1,2-dichloroethane solvent, a first heating stirring reaction is carried out under the catalysis of diphenyl phosphate, after TLC monitoring shows that the conversion of quinoline nitrogen-oxide of formula 1 compound is complete, trichloroacetic acid and molecular sieve dehydrating agent are added, a second heating stirring reaction is carried out, the reaction is monitored until complete through TLC, the solvent is evaporated, and then purification is carried out to obtain the indole derivative. The method has the advantages of high atom economy, mild reaction condition, green, low cost, high conversion rate and the like, meanwhile, the method is a carbon recombination strategy for directly editing a molecular skeleton, can provide a new idea for late-stage design and optimization of a drug molecule, and can accelerate the drug discovery and development process, and has good theoretical value and application prospect.

The invention relates to the technical field of biological detection, in particular to sample treatment liquid and application thereof in ELISA (enzyme-linked immunosorbent assay) detection of milk and milk products. The sample treating fluid comprises the following components in percentage by weight: 2-3% of disodium ethylene diamine tetraacetate dihydrate; 0.075 to 0.125% of trichloroacetic acid; 10 to 30% of methanol; and the balance of ultrapure water. The sample is milk and a milk product. The sample treatment liquid provided by the invention can efficiently and conveniently reduce matrix interference of milk and milk products in ELISA detection, so that the detection accuracy, precision and recovery rate can be remarkably improved.

Topical formulations comprising peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid or acetic acid and hydrogen peroxide are useful for promoting hair growth and for preventing hair loss.

According to the present disclosure, a simple and accurate method for quantifying ergothioneine in a sample containing globin protein can be provided. A method for quantifying ergothioneine in a collected sample, comprising: (A) heating the sample; (B) mixing the heated sample with trichloroacetic acid; and (C) subjecting the sample obtained in step (B) to a quantitative operation; A method comprising:

The present invention addresses the problem of providing an albumen hydrolysate that has emulsifiability, emulsion stability and heat coagulability. An albumen hydrolysate obtained by hydrolysis of albumen with a protease, wherein the dry weight of a precipitate formed by adding nine times the amount of 0.4 M trichloroacetic acid (TCA) to the albumen hydrolysate is 60% or more relative to the dry weight of albumen treated in the same manner.

The present invention discloses a method for enriching and separating sulfonamide antibiotics in drinking water or milk, comprising the following steps: sample processing: adding trichloroacetic acid solution to the sample, vortexing and then ultrasonically centrifuging, and collecting the supernatant; magnetic deep eutectic solvent synthesis: stirring choline chloride, phenol and ferric chloride at room temperature to form a magnetic deep eutectic solvent; magnetic deep eutectic solvent / salt two-phase aqueous system: adding the formed magnetic deep eutectic solvent to the supernatant, vortexing and oscillating, adding salt, vortexing and oscillating, to form a magnetic deep eutectic solvent / salt two-phase aqueous system; extraction: placing a magnet at the bottom of the solution to attract magnetic droplets, moving the magnet upward to achieve phase separation of the two-phase aqueous system, accurately measuring the volumes of the upper and lower phases, and using a high performance liquid chromatograph to determine the concentration of sulfonamide antibiotics in the lower inorganic salt phase. This method can efficiently separate and enrich sulfonamide antibiotics, and the selected solvent is non-toxic and pollution-free, providing a new idea for the separation and enrichment of trace sulfonamide antibiotics.

Disclosed is a detergent composition, comprising the following reagent and reagent combination: a first reagent, i.e., a potassium salt or a sodium salt; and a second reagent combination, i.e., trichloroacetic acid, acetonitrile, cyclodextrin, or a cyclodextrin derivative. The detergent composition in the present disclosure can be used to remove a surfactant used in a protein extraction process.

The invention relates to a SiO2-coated Al2O3 loaded rare earth three-way catalyst, a preparation method thereof and application of the catalyst in polycarbonate synthesis, and belongs to the technical field of polymer synthesis. According to the catalyst, SiO2-coated Al2O3 serves as a carrier to load a rare earth three-way catalyst, SiO2-coated Al2O3 is of a double-layer structure, the inner layer of SiO2-coated Al2O3 is SiO2, the outer layer of SiO2-coated Al2O3 is Al2O3, and the rare earth three-way catalyst contains yttrium trichloroacetate, glycerin and diethyl zinc. The SiO2-coated Al2O3 carrier with a double-layer structure is prepared, and the rare earth three-way catalyst is loaded by utilizing the characteristics of large specific surface area, abundant radial pore structures and abundant contactable active surfaces of the SiO2-coated Al2O3 carrier, so that the efficient polycarbonate synthesis catalyst is obtained; the catalyst has the characteristics of high catalytic efficiency (TON), high polycarbonate molecular weight, high carbonate chain link content, easiness in separation after the reaction is finished, and the like.

The invention provides a method for separating extracellular polymeric polysaccharides and extracellular polymeric proteins, and relates to the technical field of organic matter separation.The method for separating the extracellular polymeric polysaccharides and the extracellular polymeric proteins comprises the following steps that a natural soil sample is taken and treated through a cation exchange resin method, and the treated natural soil sample is obtained; obtaining a soil extracellular polymer mixture; a trichloroacetic acid solution is added into the soil extracellular polymeric substance mixture, uniform mixing is conducted, centrifugal treatment is conducted, supernate and sediment are separated, the supernate comprises extracellular polymeric substance polysaccharide, and the sediment comprises extracellular polymeric substance protein and humic acid impurities; the method comprises the following steps: separating extracellular polymeric polysaccharide and extracellular polymeric protein at low temperature by using trichloroacetic acid, removing humic acid impurities doped in the extracellular polymeric protein by using acetone cleaning, urea treatment denaturation and trypsin enzymolysis operation, and desalting by using a polypeptide desalting centrifugal column to obtain purified extracellular polymeric protein.

Pharmaceutical, dental, cosmetic and dermatological compositions comprising an addition salt of trichloroacetic acid, one or more hydroxy acids and optionally glutamic acid or bioisosteres of glutamic acid and phytic acid are useful for peeling of the gum collar, exfoliating the skin, resurfacing, treating skin hyperpigmentation, controlling sebum production, acne, reducing pore size and reducing the appearance of scars and uneven skin tone without causing undesirable side effects, for fibroblast stimulation, transdermal biorevitalization, stimulation of new collagen production, for aesthetic improvement, skin whitening, skin brightening, skin tightening and skin rejuvenation.

The present invention discloses a metal electrode modified with VB12 / graphene modified epoxy resin and its application in catalytic dechlorination of trichloroacetic acid. In the present invention, the metal electrode modified with VB12 / graphene modified epoxy resin is used as the cathode, and the graphite electrode is used as the anode to form an electrolytic cell device for catalytic electrolysis of the chlorinated disinfection by-product trichloroacetic acid. The highest degradation rate reaches 60% within 6 h of electrolysis, and it is expected to improve the electrolysis efficiency by increasing the graphene doping ratio. Targeted dechlorination is achieved, which has the advantages of strong dechlorination target, high dechlorination efficiency, no secondary pollution, simple electrolytic device and low cost, providing an excellent method for dechlorination of the chlorinated disinfection by-product trichloroacetic acid.

The invention discloses a method for preparing short-chain diacid by degrading polyethylene with flue gas. The method comprises the following steps: mixing an ionic liquid and polyethylene, and reacting in a flue gas and air environment to obtain the short-chain diacid; the ionic liquid comprises [trihexyltetradecyl phosphorus] [benzenesulfonic acid], [trihexyltetradecyl phosphorus] [trifluoroacetic acid], [trihexyltetradecyl phosphorus] [acetic acid], [trihexyltetradecyl phosphorus] [trichloroacetic acid] and the like. The method not only can realize polyethylene degradation and flue gas denitration treatment, but also can realize efficient preparation of short-chain diacid, the concentration of NOx in the tail gas after reaction is lower than 50ppm, the process is green and pollution-free, the operation is simple, and the concept of green chemistry is practiced from multiple angles.

This invention discloses a method for the electrocatalytic hydrogenation dehalogenation of haloacetic acids or halomethanes in water. A conductive material surface-modified with ruthenium or platinum is used as the catalytic cathode, and water is used as the hydrogen source to electrochemically hydrogenate and dehalogenate haloacetic acids or halomethanes in water into acetic acid or methane. The precious metals in the catalytic cathode of this invention are cheaper; the unit price of ruthenium is much lower than that of palladium and rhodium. Compared with palladium-modified catalytic cathodes, the dechlorination selectivity is higher, with an 11.7% increase in the selectivity for the hydrogenation and dechlorination of trichloroacetic acid in water to acetic acid.

Topical formulations containing peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid, or acetic acid and hydrogen peroxide are useful for promoting hair growth and preventing hair loss.

The present application relates to the technical field of determination of nifursol metabolite content, and particularly relates to a method for determining the residual amount of nifursol metabolite in royal jelly. The method comprises the following steps: the royal jelly sample is sequentially subjected to trichloroacetic acid hydrolysis, o-nitrobenzaldehyde derivatization and ethyl acetate purification, and is treated with acetonitrile aqueous solution to constant volume, the pretreated sample is subjected to gradient elution using 5 mmol / L ammonium acetate aqueous solution-acetonitrile as a mobile phase, and is determined by liquid chromatography-tandem mass spectrometry, and the isotopic internal standard method is used for qualitative and quantitative analysis during determination. The royal jelly sample is hydrolyzed using a trichloroacetic acid solution before derivatization treatment, so that the to-be-measured component is well separated from the sample matrix, the matrix influence is reduced, and then the liquid chromatography-tandem mass spectrometry analysis is performed in combination with the selection of the mobile phase and the isotopic internal standard method, thereby improving the qualitative and quantitative accuracy of the residual amount of nifursol metabolite in royal jelly.

The invention discloses a method for detecting related substances of chloral hydrate and a preparation thereof, which adopts a high performance liquid chromatography, and the chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a chromatographic column of a filler, an acid-containing aqueous solution is used as a mobile phase A, acetonitrile is used as a mobile phase B, and gradient elution comprises 90-97% of the mobile phase A in 0-5min; the mobile phase A is 80-90% in 9-12 min; the mobile phase A accounts for 10-30% in 25-35 min; according to the related substance detection method, degradation impurities such as formic acid, acetic acid and trichloroacetic acid and process impurities such as 2, 2, 3, 3-tetrachlorosuccinic acid can be detected at the same time by optimizing the elution gradient, and the detection method is high in sensitivity, accuracy and precision and good in reproducibility.

Provided is the large-scale preparation of a high-purity hydrolyzed colanic acid or a salt thereof. The method comprises: 1) adding a solution containing a colanic acid or a salt thereof to a colanic acid degradation enzyme comprising an amino acid sequence as shown in SEQ ID NO: 1 or having at least 90% sequence identity thereto; and 2) performing an enzyme termination reaction, wherein the termination in step 2) is achieved by means of a termination agent, a boiling water bath and / or an ice bath, wherein the termination agent is selected from one or more of activated carbon, absolute ethanol, methanol, EDTA, trichloroacetic acid and sodium carbonate, and preferably, activated carbon is used to achieve the termination in step 2), so as to obtain the hydrolyzed colanic acid or a salt thereof. The molecular structure of the hydrolyzed sodium colanate prepared by the provided method features acetylation and pyruvic acid modification. Moreover, the preparation conditions are mild, the production cost is low, continuous production can be achieved, and industrial scale-up is easily implemented. The prepared hydrolyzed sodium colanate has the characteristics of high purity and low endotoxin residue, and has potential and broad application value in fields such as cosmetics, medical devices, and oligosaccharide drugs.

This invention discloses a biomimetic-microwave-assisted alkaline extraction combined with ultrasonic extraction method for extracting acidic pine polysaccharides, belonging to the field of polysaccharide technology. The method includes the following steps: Step 1, enzymatic hydrolysis; Step 2, microwave-assisted alkaline extraction; Step 3, ultrasonic-assisted extraction; Step 4, combining the extracts to obtain a concentrated solution, precipitating with alcohol overnight, centrifuging, discarding the supernatant, redissolving the precipitate in deionized water, adding trichloroacetic acid (TCA), stirring, incubating overnight at 0-4°C, centrifuging, dialyzing the supernatant, and then freeze-drying to obtain acidic pine polysaccharides. This biomimetic-microwave-assisted alkaline extraction combined with ultrasonic extraction method for extracting acidic pine polysaccharides significantly improves the polysaccharide yield, is environmentally friendly, enhances the immunomodulatory activity of the polysaccharides, and solves various problems in traditional extraction methods.