83 results about "Fish bone" patented technology

The utility model relates to the technical field of food processing, in particular to a fishbone removing machine which comprises a supporting mechanism and a fishbone removing mechanism used for removing fishbones, and the fishbone removing mechanism is fixed above the supporting mechanism. The fishbone removing mechanism is arranged, when the fishbone removing device is used, a fishtail is placed on the mechanical clamping jaw, the mechanical clamping jaw is started, the mechanical clamping jaw operates to clamp and fix the fishtail, an electric push rod is controlled to stretch, the electric push rod stretches to drive a movable block and a cutter to move, the cutter moves to make contact with a fish body, and a motor is started; the motor runs to drive the rotating shaft and the winding drum to rotate, the winding drum rotates to wind the traction rope, the mechanical clamping jaw and the fish start to ascend, in the ascending process, the cutter cuts off fish meat on the two sides of the fish bone, the motor stops running when the mechanical clamping jaw ascends to the corresponding position, fish meat cutting is completed, and the cut fish meat falls into the collecting box; by means of the mode, fish meat on the two sides of the fishbone can be rapidly cut off, and the fish meat and fishbone separation efficiency is effectively improved.

The invention discloses a preparation method of composite active peptide with anti-wrinkle, whitening and freckle-removing effects from marine fish byproducts, cod byproducts, namely fish heads, fish bones and fish skins, are used as raw materials and are mixed according to the mass ratio of 3: 3: 4, and the composite active peptide is prepared through the steps of pretreatment, enzymolysis, enzyme deactivation, centrifugal separation and purification. A compound enzyme used in the enzymolysis step is composed of trypsin and papain according to a certain proportion, and the enzyme addition amount, the enzymolysis time, the enzymolysis temperature and other conditions are optimized. The prepared composite active peptide with the anti-wrinkle, whitening and freckle-removing effects from the marine fish by-product has good anti-wrinkle, whitening and freckle-removing effects, resource utilization of the cod by-product is achieved, and the composite active peptide has high application value.

The invention discloses a fish body slicing and sorting integrated device, which relates to the technical field of food processing equipment, and comprises a rack, a claw bracket, a fish meat bracket, a blade bracket, a sorting air tap, a blanking air tap and a fish bone separation cutter. The invention further discloses a processing method of the fish body slicing processing and sorting integrated device. The processing method comprises the steps of feeding, separating bones from meat, slicing fish meat, sorting fish slices and discharging. By arranging the fishbone hooks, the fish meat bracket and the fishbone separation cutter, when a fish body is sliced, the upper and lower groups of fishbone hooks can be turned over and inserted into the end part of the fishbone in the fish body and clamp the forked part of the fishbone, so that the fishbone is hooked, and the fishbone hooks can horizontally drive the fish body to move; in the traction process of the fish body, the obliquely designed fishbone separation cutter can be inserted into the fish body and is attached to the surface of the fishbone, so that the fishbone and the fish meat are separated in the traction process of the fish body.

The invention belongs to the technical field of biology, and particularly relates to a construction method of epigenome edited zebrafish, sgRNA of a targeted zebrafish runx2b gene promoter region and application of the sgRNA. The invention provides a construction method of epigenome edited zebrafish, which comprises the step of carrying out methylation editing by using a CRISPR / dCas9-methyltransferase system targeting runx2b gene promoter region, thereby inhibiting runx2b gene expression and reducing intermuscular bone formation. According to the method, the expression level of the runx2b gene is accurately regulated and controlled through an epigenetic editing technology on the premise that a DNA sequence is not changed, and formation of fish intermuscular bones is effectively reduced. The zebra fish F0 treated by the method represents that the runx2b mRNA expression level is obviously reduced, and the intermuscular bones of the eleventh to sixteenth sarcomedo regions of adult F0 generation fish are obviously shorter than those of a control group, and the shortening range reaches 23.3% to 38.8%. Besides, the method provides theoretical basis and technical support for improving fish economic traits by accurately regulating and controlling the expression mode of the key economic trait gene and simultaneously keeping the integrity of genome DNA (Deoxyribose Nucleic Acid).

The invention relates to the technical field of biology, in particular to a biological substrate modification composition, a preparation as well as a preparation method and application of the biological substrate modification composition. The biological substrate modification composition provided by the invention is prepared from the following components: bacillus subtilis YXSY-01 bacterial powder, sphingomonas aquatic bacteria HD-01 bacterial liquid, bentonite, oyster shell powder, attapulgite, zeolite powder, fish bone meal of raw fish and water. The biological substrate modification composition is prepared from the following raw materials in parts by weight: 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch and 20-30% of corn starch. The biological substrate modification composition and the preparation provided by the invention have the capabilities of degrading faeces of bred animals and reducing the content of nitrite. The composition and the preparation can reduce the accumulation of excrement of cultured animals in a culture pond, reduce the nitrite content, purify the water quality of the culture pond and reduce the morbidity of the cultured animals.

1. Name of the designed product: ceramic tile (streaming stone companion · fish bone). 2. Use of the designed product: the designed product is a building decoration product, specifically a wall and floor decoration tile. 3. Design points of the designed product: the shape and pattern shown in design 1 front view. 4. Picture or photo that best indicates the design points: design 1 front view. 5. The rear view, left view, right view, bottom view and top view of design 2, design 3 and design 4 are the same as design 1, and the rear view, left view, right view, bottom view and top view of design 2, design 3 and design 4 are omitted. 6. Design 1 is designated as the basic design.

The invention belongs to the technical field of solid waste treatment, and particularly discloses a preparation method for increasing the content of soluble calcium in fish bones. The method comprises the following steps: pretreating fish bones to obtain fish bone powder; mixing fish bone meal and water, and sterilizing to obtain a fermentation substrate; according to the method, bacillus subtilis, lactobacillus plantarum and saccharomycetes are adopted for multi-strain sequential fermentation, the bacillus subtilis is inoculated firstly for ventilation fermentation for 2-4 days, the pH is adjusted to 6.5-7.0, then sterilization is performed, a carbon source is added, a mixed bacterium solution of the lactobacillus plantarum and the saccharomycetes is inoculated, and ventilation fermentation is performed for 2-4 days. Through a specific strain combination and an innovative sequential fermentation process, the enzyme production capacity of bacillus subtilis and the acid production capacity of lactobacillus plantarum and saccharomycetes are remarkably improved, dissolution of calcium in fish bones is synergistically promoted, the problem of bitter taste generated by a traditional enzymolysis method is avoided, and the method has the advantages of high efficiency, greenness and complete nutrition retention.

The invention discloses a preparation method of micro-nano fishbone dust particle-based Pickering emulsion and a product, and belongs to the technical field of food processing, fishbone is sequentially subjected to enzymolysis, degreasing, high-pressure cooking and drying, and fishbone coarse particles are obtained; carrying out micro-nano processing on the fishbone coarse particles to obtain micro-nano fishbone particles; mixing the micro-nano fishbone particles with water, and performing mechanical homogenization and ultrasonic treatment in an ice bath to obtain a micro-nano fishbone particle dispersion liquid; and mixing the micro-nano fish bone particle dispersion liquid with liquid oil, and carrying out homogeneous emulsification in an ice bath to obtain the micro-nano fish bone powder particle-based Pickering emulsion. The invention provides the Pickering emulsion prepared by taking the food-grade micro-nano fishbone particles as the solid stabilizer, the Pickering emulsion has wide application potential and prospect, sustainable full utilization of aquatic product processing by-product fishbone is realized, resources are saved, and environmental pollution is reduced.

1. The name of the design product: bone sawing machine. 2. The use of the design product: used for cutting various small and medium-sized animal bones, frozen meat, belt fish bones, frozen fish, ice blocks. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view. 5. The bottom of the design product is not easy to see or not visible during use, omit the top view.

1. The name of the design product: fishbone clip. 2. The use of the design product: used for removing fish bones or fish bones when cooking or processing fish. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention discloses a middle bone removing slicer for yellow croaker production, which comprises a machine main body, first feeding belts, a bone removing blade, a second feeding belt and an adjusting plate, the bone removing blade is mounted on the surface of the machine main body through a rotating rod, and the first feeding belts are mounted on the surface of the machine main body on one side of the bone removing blade through a first rotating cylinder; the second feeding belts are installed on the surfaces of the portions, on the two sides of the boning blade, of the machine body through second rotating cylinders, the adjusting plates are arranged at one ends of the surfaces of the machine body, driving grooves are formed in the portions, below the adjusting plates, of the machine body, two-way lead screws are installed in the driving grooves, and the outer walls of the two-way lead screws are sleeved with sliding blocks in a threaded mode. The yellow croaker deboning and slicing device not only can automatically deboning and slicing, can flatten yellow croaker bodies and improve the accuracy of deboning and slicing, but also can wash and drain fish meat, so that the fish meat and fish bones are kept clean.

1. Name of the product in this design: Pull-out clip. 2. Purpose of this design: For plucking hair and removing fish bones. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application discloses a preparation method of sturgeon peptide and application of the sturgeon peptide in improving immunity and sexual function. The method comprises the following steps: S1, one or more of sturgeon cartilage, fish bone and fish skin are crushed after being thawed, and pure water is added according to a material-liquid ratio of 1:3-1:4 and is pumped into an enzyme hydrolysis tank; S2, the enzyme hydrolysis tank is heated to 85-90 DEG C under the condition of a closed low pressure of 0.06-0.08 MPa, and protein is denatured for 15-20 min; S3, the temperature is reduced to 60-65 DEG C, the pH is adjusted to 8.0-8.5, 2‰-3‰ alkaline protease of the raw material amount is added, and constant-temperature enzyme hydrolysis is carried out for 170-190 min; the temperature is increased to 85-90 DEG C after the enzyme hydrolysis is completed, and the enzyme is inactivated for 14-16 min; S4, decolorization is carried out; S5, filtration and concentration are carried out; S6, vacuum concentration is carried out; S7, sterilization and drying are carried out, and sturgeon peptide finished products are obtained. The sturgeon peptide obtained by the preparation method has small molecular weight and high active ingredients.

The present invention discloses the application of deer horn glue in the treatment of zebrafish bone injury, belonging to the technical field of fish bone injury. The present invention prepared deer horn glue and used LPS induction to establish a zebrafish bone injury model for comprehensive evaluation. The IC50 of deer horn glue in zebrafish was 206.3 μg / mL; the treatment with deer horn glue could alleviate the inhibitory effects of LPS on cartilage development and bone formation in a dose-dependent manner; it could significantly reduce the green fluorescence intensity of macrophages and inhibit the activation of macrophages induced by LPS; it inhibited the excessive secretion of inflammatory factors IL-6, IL-1β and NO; it significantly restored the mRNA levels of bone-related genes COL2α1 and Sox9a. This study confirmed that deer horn glue could alleviate zebrafish bone injury caused by LPS and at the same time inhibit the macrophage-mediated inflammatory cascade reaction, providing a basis for the treatment of fish bone diseases.

The utility model belongs to the technical field of pet supplies, and particularly relates to a fish-shaped food leakage pet toy. The fish-shaped food leakage pet toy comprises a fish head, a fish bone and a fish tail which are detachably connected in sequence, wherein the fish head comprises a sounding whistle arranged at the top of the fish head; the fishbone comprises a main body part for storing granular feed, a plurality of convex parts arranged on the main body part and granular feed temporary storage spaces formed on the convex parts and communicated with the main body part; the fishtail comprises a vibrator arranged on the fishtail. According to the fish-shaped food leakage pet toy, the specific structure of the fish-shaped food leakage pet toy is limited, so that the fish-shaped food leakage pet toy simulates the shape of a fish through mutual cooperation of the fish head, the fish bone and the fish tail which are detachably connected in sequence, and the pet food is added to the fish bone, so that the pet food leakage effect is improved. The pet can recognize and pay attention to the fish-shaped food leakage pet toy through vision and smell, the interest of the pet is improved, the pet is attracted to actively play with the fish-shaped food leakage pet toy, and the feeding and playing fun of the pet is improved.

The invention discloses energy-saving fish meat rapid separation equipment, and relates to the technical field of energy-saving aquatic product processing equipment.The separation equipment comprises a feeding bin, a meat separation barrel is arranged below the feeding bin, a meat separation belt is arranged below the meat separation barrel, and an adjusting mechanism used for adjusting the posture of fish meat is arranged in the feeding bin; through cooperation of a shifting plate and an auxiliary plate, the posture of fish meat fed into the feeding bin can be adjusted, so that the fish meat can enter in a horizontal posture when entering the meshing position of a meat separation barrel and a meat separation belt, the contact area of the fish meat with the meat separation barrel and the meat separation belt is increased, the fish meat is prevented from being wrapped by fish bones, fish skin and other impurities, and the meat separation efficiency is improved. According to the device, the posture of the fish meat is adjusted, the fish meat separation effect is influenced, secondary adjustment can be performed on the fish meat after posture adjustment through movement of the matching plate and the matching rod, part of the fish meat without posture adjustment can also be greatly adjusted, the requirement that the fish meat enters the meshing position of the meat separation barrel and the meat separation belt subsequently is met, and the fish meat separation effect is improved.

The utility model discloses an anti-splash anti-slip sole, which relates to the technical field of soles, aims to solve the problem that the existing shoes are easy to splash when stepping on water, and adopts the technical scheme that the anti-splash anti-slip sole comprises a sole, the sole is provided with a main drainage groove, a plurality of side drainage grooves and edge drainage grooves, and the side drainage grooves and the main drainage groove form a fishbone shape. The main drainage groove penetrates through the edge of the shoe sole, a blocking piece is arranged in the area, where the main drainage groove penetrates through, of the shoe sole in a rotating mode, and a fixing piece is arranged between the blocking piece and the shoe sole. According to the anti-splashing and anti-skidding shoe sole, when a child wears a shoe with the shoe sole and steps on water, the water can flow to the toe cap in the flowing process, and splashing of water can be reduced to the maximum extent due to the structural arrangement of the edge drainage grooves.

The utility model discloses a meat and bone separating device for surimi production, and relates to the technical field of separating devices. The meat and bone separating device for surimi production comprises a crushing assembly, and the crushing assembly comprises a crushing cylinder; and the separation assembly comprises an L-shaped discharging pipe embedded in the outer surface of the crushing barrel and extending into the crushing barrel, and a separation net barrel fixedly arranged at the end of the L-shaped discharging pipe. By arranging the crushing assembly and the separating assembly, fish meat can be crushed firstly, meanwhile, the crushed fish meat can be synchronously conveyed into the separating net barrel, and the fish meat in the separating net barrel is extruded under the action of rotation of spiral extrusion blades, so that meat paste is extruded and separated out through the separating net barrel; and the fish bones are discharged through the conical slag discharging pipe, so that rapid separation of the fish meat and the fish bones is realized, and the fish meat and fish bone separation efficiency is effectively improved by adopting an extrusion type separation mode.

A method for continuously removing fish heads and internal organs is disclosed. A fish head and internal organs removal machine is used to remove fish heads and internal organs. The method comprises the following steps: placing a fish flat in a fish holding tank; a first cutter cuts the upper portion of the connection between the fish head and body; a second cutter cuts the lower portion of the connection between the fish head and body; a fish body conveyor belt conveys the fish body in the fish body tank backward; a fish head conveyor belt rotates the fish head tank around a first center; and a third cutter cuts the fish back at the connection between the fish head and body. The method uses the first and second cutters to cut open both sides of the connection between the fish head and body, and the third cutter to cut off the fish bones at the connection between the fish head and body at the fish back. This method can process fish of various types and sizes, and is highly versatile. The fish head conveyor belt and the fish body conveyor belt convey synchronously and then separately. During the separate conveyance, the fish head is twisted, pulling the internal organs out of the fish body. The entire process can be performed continuously as the fish head conveyor belt and the fish body conveyor belt operate.

The utility model discloses a fishbone multifunctional lure bionic bait. The fishbone multifunctional lure bionic bait comprises a profiling bait body, an integrated steel wire, a fishbone, a balancing weight and a hook body. The integrated steel wire penetrates through the profiling bait body to form a fish spine, a fishing line hanging lug and a hook body hanging lug are arranged at the two ends of the integrated steel wire respectively, and a single hook or three hooks can be hung on the hook body hanging lug. The fish bones are located on the two sides of the steel wire, a balancing weight is arranged in the profiling bait body, the fish bones are coated with fluorescent paint, 3D profiling fish eyes and three-dimensional fish gills are arranged at the front ends of the fish bones, and the profiling bait body is of a solid structure. The bionic bait is firm in structure, the fluorescent paint improves visual attraction in the daytime, the bait is more striking at night, the fishing rate is improved, and environmental protection is achieved. The balancing weight enables the bait to act naturally, the fishing probability and the tension value of the hook body are increased, the whole body is solid and resistant to biting, the service life is long, the sense of reality is enhanced through the 3D fisheye and the three-dimensional gill, and the lure fishing effect is effectively improved.

The utility model discloses a production device of a seaweed fish protein small molecule peptide composition, which belongs to the technical field of production devices, aims to solve the problem of low efficiency when fish bones are cleaned at present, and comprises a base, an electric control box is mounted on the side surface of the base, and a cleaning pipe is mounted on the surface of the base. A material guiding frame capable of guiding out materials in the cleaning pipe is installed on the cleaning pipe, a discharging end for receiving the materials guided out of the material guiding frame is arranged in the cleaning pipe, cleaning operation is conducted in the cleaning pipe during cleaning, then the cleaned materials are guided out through the material guiding frame, and the materials are conveyed to the cleaning pipe through the discharging end. Materials can fall into the discharging end under the action of gravity, so that full-automatic material cleaning operation can be conducted, the fish bone cleaning requirement is met, manual intervention on cleaning is basically not needed, and the situation that a human body is scratched by the fish bones can be effectively avoided.

The invention discloses a bone-derived collagen peptide with a joint protection effect and a preparation method thereof, and belongs to the technical field of collagen peptide preparation, the preparation method comprises the following steps: S1, cleaning and crushing fresh fish bones, and performing impurity protein removal treatment on fish bone powder by using a 0.1 M NaOH solution to obtain pretreated bone powder; s2, mixing the pretreated bone meal with 0.5-1.5 mol / L hydrochloric acid according to a solid-to-liquid ratio of 1: 5, and carrying out a decalcification reaction for 2-4 hours to obtain decalcified bone collagen; s3, performing sequential enzymolysis on the decalcified ossein by adopting pepsin and trypsin to obtain enzymatic hydrolysate; and carrying out inactivation, purification, vacuum concentration and freeze drying on the enzymatic hydrolysate to obtain the collagen peptide. According to the collagen peptide and the preparation method, the characteristic amino acid content of the prepared collagen peptide is increased by 40% or above compared with that of a traditional process, it is ensured that the collagen peptide is combined with a cartilage cell receptor in a targeted mode and inhibits secretion of inflammatory factors, and the inhibition rate reaches 58-68%; at a concentration of 500 [mu] g / mL, there is no toxicity to HaCaT cells (IC50gt; and the traditional Chinese medicine composition has no toxic or side effect and no skin irritation.

The invention relates to a preparation method of a narrow gadus bone peptide compound and chelated calcium of the narrow gadus bone peptide compound. The method comprises the following steps: by taking a walleye cod processing byproduct fish bone as a raw material, carrying out trypsin preliminary enzymolysis, ultrafiltration and protease K targeted enzymolysis to obtain the walleye cod bone peptide compound. The narrow gadus bone peptide compound comprises one or more active peptides of DFF, DIF, DNAF, DPF and DYF. Chelated calcium can be prepared by using the narrow gadus bone peptide compound or the narrow gadus bone active peptide. Waste resources are fully utilized, high value of low-value products is achieved, environmental pollution is reduced, high economic and social benefits are achieved, and the prepared chelated calcium with the high additional value can be applied to the fields of dietary nutrition, biological medicine products and the like.

This application discloses a seafood soy sauce made from blackfish bones and soy sauce residue, and its preparation method. The method involves treating blackfish bones using a combination of enzymatic hydrolysis and fermentation techniques. First, an enzymatic fermentation broth is prepared from the blackfish bones. This broth is then mixed with soy sauce residue and salt for a second fermentation to obtain the original soy sauce. Finally, the seafood soy sauce is prepared through a blending process. This invention employs a segmented fermentation process: first, the blackfish bones undergo short-term liquid fermentation, then the fermentation broth is mixed with soy sauce residue and salt for long-term static fermentation. This method fully utilizes the lactic acid bacteria and yeast in the blackfish bone fermentation broth to promote the release of flavor compounds, while effectively reducing the fishy smell of the enzymatic hydrolysate.

The present invention discloses a method for identifying the origin of basa fish based on stable isotopes, comprising the steps of constructing a sample library of basa fish from the Mekong River, separating and obtaining the fleshy part of each sample, obtaining the tip of the fishbone, and removing the base of the fishbone where the fishbone is connected to the fishbone to obtain the fishbone; and detecting the δ 13 C value, according to the detected fishbone δ 13 C、fishbone δ 13 C and fleshy part δ 13 C respectively constructed the 13 C isotope database, obtain the fishbone δ 13 The 95% confidence interval of C, the standard interval of η2, and the δ 13 C value, and obtain the η2 value of the Basa fish to be tested. If the test value is consistent with the fish bone δ 13 If the 95% confidence interval of C and the standard interval of η2 are met, the origin of the sample is determined to be the Mekong River. Otherwise, the sample to be tested is determined to be falsely labeled. Compared with traditional detection methods, the present invention has high efficiency and accurate results.

1. Name of the design product: fish bait (fish bone resin). 2. Use of the design product: fish bait for fishing. 3. Design points of the design product: in shape. 4. Picture or photo that best shows the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention discloses an antioxidant liquid collagen peptide as well as a preparation process and application thereof, and particularly relates to the technical field of extraction of fish collagen peptides. Aiming at different characteristics of the fish skin, the fish scales and the fish bones, the preparation process adopts a differential treatment method: the fish skin is degreased and then is subjected to enzymolysis by adopting alkaline protease; freezing and grinding the fish scales, decalcifying citric acid, and performing enzymolysis by adopting collagenase; the fish bones are subjected to enzymolysis by neutral protease after being degreased and decalcified; the three enzymatic hydrolysates are mixed in proportion and then subjected to adsorption, multi-stage membrane filtration and low-temperature concentration, and the liquid collagen peptide with the solid content of 30%-40% is prepared, according to the scheme, the process operation is simple and convenient, extraction is conducted under the low-temperature condition, the oxidation resistance of the collagen peptide can be effectively reserved, and the raw material utilization rate is high.

The application discloses an energy-saving fish meat rapid separation device, and relates to the technical field of energy-saving aquatic product processing equipment.The separation device comprises a feeding bin, a meat collecting cylinder is arranged below the feeding bin, a meat collecting belt is arranged below the meat collecting cylinder, an adjusting mechanism for adjusting the posture of fish meat is arranged in the feeding bin, the posture of fish meat input into the feeding bin can be adjusted through cooperation of a lever and an auxiliary plate, so that the fish meat can enter the engagement position of the meat collecting cylinder and the meat collecting belt in a horizontal posture, the contact area of the fish meat with the meat collecting cylinder and the meat collecting belt is increased, the fish meat is prevented from being wrapped by impurities such as fish bones and fish skin, and the fish meat separation effect is affected, the fish meat after posture adjustment can be secondarily adjusted through movement of a cooperation plate and a cooperation rod, part of the fish meat without posture adjustment can also be greatly adjusted, the requirement of entering the engagement position of the meat collecting cylinder and the meat collecting belt is met, and the fish meat separation effect is improved.

The invention discloses application of irbesartan in preparation of a medicine for preventing or treating osteoarthritis, and belongs to the technical field of biological medicine. Osteoarthritis single cell transcriptome data are integrated and analyzed, differential expression genes are screened, and irbesartan is screened by using a relocation method and Mendel randomization analysis to serve as a medicine for treating osteoarthritis; analysis results show that irbesartan can significantly reduce the risk of osteoarthritis. An irbesartan administration experiment is carried out by using a zebra fish bone arthritis model, and the experiment result shows that irbesartan obviously increases the joint gap of anal fins of zebra fish and has an obvious protection effect on articular cartilage; a transcriptome sequencing result shows that irbesartan plays the role by inhibiting the MAPK signal channel. The invention provides the effect of irbesartan in the development of osteoarthritis for the first time, provides a new strategy for prevention and treatment of osteoarthritis, and has a wide application prospect.