198 results about "Chondroitin" patented technology

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The invention discloses starch-collagen composite hydrogel as well as a preparation method and application thereof. Collagen is catalyzed by microbial transglutaminase to form a covalent cross-linked network, and meanwhile, hydroxypropyl starch is introduced to construct a physical interpenetrating network through molecular chain penetration and hydrogen-bond interaction; and chondroitin sulfate is further integrated to strengthen the network structure and biological activity through electrostatic interaction. The method is mild in condition and does not need a toxic chemical cross-linking agent, the obtained composite hydrogel has an interpenetrating double-network structure and has excellent mechanical properties, enzymatic degradation resistance and cell affinity, the compression modulus of the composite hydrogel is remarkably improved, the composite hydrogel can keep structural stability for a long time in a collagenase environment, cell adhesion and proliferation can be effectively promoted, and the composite hydrogel has a good application prospect. The hydrogel can be widely applied to tissue engineering scaffolds, wound dressings, drug sustained-release carriers and cartilage repair materials.

The application belongs to the technical field of chondroitin sulfate preparation, and particularly relates to application and application method of liquid sulfur dioxide in preparation of chondroitin sulfate or chondroitin sulfate salt. In the application, liquid sulfur dioxide is used as a solvent to perform sulfonation modification treatment on unsulfated chondroitin, on the one hand, the use of traditional high-boiling organic reagents is avoided, the difficulty of three-waste treatment is reduced, and the process is more green and environmentally friendly; on the other hand, the post-treatment operation of the sulfonation reaction is simpler, and sulfur dioxide can be removed from the system by only temperature control or pressure adjustment, so that solvent residues possibly existing in the final product are avoided, and the product is safer. In addition, by adjusting the key conditions of the sulfonation reaction, the proportion of chondroitin sulfate with 6 independent sulfation in the disaccharide unit of the sulfonation product is 70% to 90%, the reaction is stable and reliable, and the sulfonation rate is high.

The invention relates to the field of food deep processing, and particularly discloses a processing technology of sodium chondroitin sulfate, which comprises the following steps: S1, crushing raw materials, boiling, carrying out alkaline hydrolysis, and carrying out enzymolysis to obtain an enzymatic hydrolysate; s2, the enzymatic hydrolysate is subjected to filtration, ultrafiltration, oxidation, secondary filtration, ultrafiltration membrane filtration, alcohol precipitation, dehydration, centrifugation, drying, crushing and sieving, and a finished product is obtained; the method has the advantages of high extraction rate, high extraction rate and high purity.

The invention relates to the technical field of functional hydrogel materials, in particular to ultrasonic cavitation self-adaptive lubricating hydrogel as well as a preparation method and application thereof. According to the ultrasonic cavitation self-adaptive lubricating hydrogel provided by the invention, at least one of N-acryloyl glycinamide, N-acryloyl acrylamide and methylacryloyl chitosan is used as a monomer; at least one of sodium hyaluronate methacrylate, hyaluronic acid-polyethylene glycol double-grafted copolymer and methacrylated chondroitin sulfate is used as a lubricant, persulfate is used as an oxidizing agent, molybdenum disulfide and / or MXene are / is used as a reducing agent, the dosage ratio of all the raw materials is controlled, the characteristics of non-invasiveness and deep penetrability of ultrasonic waves can be utilized, and the high-purity chondroitin sulfate can be obtained. In-vivo controllable efficient in-situ polymerization is realized, surgical implantation wounds are avoided, the fitness of the material and tissues is improved, and an in-vivo complex microenvironment is adapted; and the raw materials are high in biocompatibility and high in biological safety.

The invention discloses a chondroitin sulfate oligosaccharide derivative and a preparation method and application thereof.The chondroitin sulfate oligosaccharide derivative is shown in the formula (I), the definition of substituent groups in the formula is shown in the specification, and the derivative comprises di-, tetra-and hexasaccharide derivatives of chondroitin sulfate B and T, has endogenous anticoagulation and anti-inflammatory activity, and can be used for preparing the chondroitin sulfate oligosaccharide derivative. The compound can be developed into anticoagulant and antithrombotic drugs.

The present application relates to a kind of self-setting composite bone implants based on gallic acid complex salt and preparation method thereof, belong to bone repair material field.The present application is specifically related to a kind of self-setting composite bone implants, it is characterized in that, component A, component B and component C, the component A is gallic acid and the complex salt of at least two metal elements, wherein the at least two metal elements are the metal element of promoting bone tissue regeneration or the trace metal element required by human body, and the at least two metal elements include calcium, the component B is the complex of calcium / strontium chondroitin sulfate and calcium sulfate, and the component C is magnesium calcium hydrogen phosphate complex.The self-setting composite bone implant of the present application has the characteristics of antibacterial, anti-inflammatory, promoting osteogenesis, instant shaping and all degradation, can meet the clinical needs of bone tumor, bone injury and the like, has wide application prospect in various bone repair, reconstruction and replacement.

The invention relates to the technical field of medical biological materials, and discloses a mussel mucin-chondroitin sulfate composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a mussel mucin aqueous solution and a chondroitin sulfate aqueous solution; the mass volume concentration of the mussel mucoprotein aqueous solution is 1%-10%, the mass volume concentration of the chondroitin sulfate aqueous solution is 1%-10%, the mass ratio of the mussel mucoprotein to the chondroitin sulfate is 3: 1-1: 3, the two solutions are mixed and stirred or oscillated under the conditions that the temperature is 4-37 DEG C and the pH value is 7.0-9.0, a cross-linking reaction is conducted, and hydrogel is formed; the cross-linking mode is physical cross-linking, chemical cross-linking or physical-chemical dual cross-linking; according to the invention, excellent tissue adhesion, injectability, self-healing property and biodegradability are realized, cell adhesion and proliferation can be effectively promoted, and the gel is suitable for various medical beauty scenes such as skin filling, wound repairing and anti-aging nursing.

The invention relates to the technical field of fertilizers, in particular to a nutrient polymerized polyglutamic acid compound fertilizer and a preparation method thereof, and the nutrient polymerized polyglutamic acid compound fertilizer comprises the following raw materials in parts by weight: 6-10 parts of gamma-polyglutamic acid, 25-30 parts of filler, 20-25 parts of a nitrogen source, 12-15 parts of a phosphorus source, 10-14 parts of a potassium source, 4-6 parts of a compound additive and 0.1-0.2 part of a fungicide. In the preparation of the granules, the humic acid powder is coated by a first treating agent prepared from the soluble starch, the salicylic acid, the sodium alginate and the like, so that the activity of the humic acid is effectively protected, and meanwhile, the mechanical strength and the slow-release characteristic of the granules are further enhanced by a second treating agent prepared from the components such as the chitosan and the fulvic acid through a chelation cross-linking effect; in addition, chondroitin sulfate, calcium nitrate, ammonium molybdate and molasses in the batch jointly provide medium trace elements and organic carbon sources, and synchronous release and efficient utilization of nutrients after the fertilizer is applied to soil are ensured.

The utility model relates to the technical field of chondroitin processing, in particular to an anti-clogging chondroitin trickling filtration device, which can effectively improve the filtering effect on water, is convenient for taking out a trickling filtration component in the device, enables the trickling filtration component to be cleaned more comprehensively and thoroughly, and prevents the device from being clogged due to incomplete cleaning for a long time. The normal use of the device is ensured; comprising a barrel and a confluence disc, three sets of supporting legs are fixedly arranged at the bottom end of the barrel in an annular array mode, a barrel cover is arranged on a cover in threaded connection with the top end of the barrel, a baffle ring is fixedly arranged on the outer wall of the barrel, and the baffle ring and the barrel are integrally formed; the bottom ends of the biochemical balls abut against the top end of the lower-layer water-passing partition plate, an upper-layer water-passing partition plate is placed at the top ends of the biochemical balls, a ceramic ring is placed at the top end of the upper-layer water-passing partition plate, filter cotton is placed at the top end of the ceramic ring, and filter cloth is placed at the top end of the filter cotton.

Described herein are targeted ChABC fusion proteins, complexes thereof, and uses thereof. The targeted ChABC fusion proteins can include a ChABC polypeptide that can be linked to a Gal-3 polypeptide. Monomer targeted ChABC fusion proteins can form homogeneous or heterogeneous complexes. The targeted ChABC fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted ChABC fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.

The present invention discloses the use of Avn Anthramides C (Avn C) as an inducer of chondrocytic differentiation in Mesenchymal Stem Cells (MSCs), providing a promising approach for regenerative cartilage therapy. By employing Avn C treatment, MSCs exhibit enhanced chondrocytic differentiation and elevated expression of key specific chondrogenic extracellular matrix (ECM) factors, notably Collagen Type II (COL2A1). Furthermore, when Avn C is used in combination with Chondroitin Sulfate (CS), a synergistic effect is observed, leading to upregulation of the transcriptional activity state of SOX9, a key regulator of chondrogenesis. The disclosed invention shows significant improvements in mRNA gene expression (ACAN, LRP1, SOX9), cellular protein levels (COL2A1, SOX9, LRP1), and functional outcomes, as evidenced by the secretion of extracellular matrix proteins (FSTL-1, BGH3, CO1A1, CO1A2, and CO3A1).

The invention relates to the technical field of sodium chondroitin sulfate, in particular to sodium chondroitin sulfate with a high cartilage repair effect and a preparation method thereof.The sodium chondroitin sulfate initial feed liquid is provided, the pH value of the sodium chondroitin sulfate initial feed liquid is adjusted to a preset acidic pH value, and at the preset reaction temperature, the pH value and the reaction temperature are maintained for reaction time, so that the chondroitin sulfate with the high cartilage repair effect is obtained. The method comprises the following steps: adding a sulfated disaccharide unit CS-0 into a feed liquid to precipitate out a non-sulfated disaccharide unit CS-0 in the feed liquid, carrying out solid-liquid separation on the feed liquid, and removing the CS-0 precipitate to obtain a supernatant; pumping the supernatant into a gradient membrane separation system under controlled transmembrane pressure difference and feed liquid temperature, and separating the supernatant into three component flows with different molecular weight intervals; the concentration of the three component flows is monitored, the volume flow of each component flow is dynamically adjusted according to the preset molecular weight and mass distribution proportion, the chondroitin sulfate sodium product with the fixed molecular weight distribution is obtained, and the biological activity and the application value of the chondroitin sulfate sodium are improved.

The invention belongs to the technical field of food preparation, and particularly relates to a biological information technology guidance-based compound bovine bone collagen peptide beverage, which is prepared from the following raw materials: bovine bone collagen peptide powder, red date polysaccharide, astragalus polysaccharide, calcium carbonate, chondroitin sulfate and sodium hyaluronate. When the compound bovine bone collagen peptide beverage is drunk, bovine bone contains a large amount of collagen, is rich in type I collagen and is richer in amino acid composition, and a large number of research results show that protein is not completely hydrolyzed into amino acid after being ingested, most of the protein is absorbed in a peptide form, and the protein is absorbed in a peptide form. Therefore, the selected bovine bone collagen peptide powder can be better absorbed by the human body. The red dates have the effects of maintaining beauty, keeping young and resisting aging. In addition, astragalus membranaceus and other traditional Chinese medicine extracts are supplemented in the compound bovine bone collagen peptide beverage, so that the functional characteristics of the beverage are enhanced, and the original bad flavor of animal peptide is improved.

The invention discloses a chondroitin sulfate modified dihydromyricetin solid lipid nanoparticle, and belongs to the field of pharmaceutics. The nanoparticle is composed of a solid lipid component, dihydromyricetin encapsulated in the solid lipid component and a chondroitin sulfate targeting ligand modified on the surface. According to the invention, the chondroitin sulfate is specifically combined with the high-expression CD44 receptor on the surface of the hepatic stellate cell, so that the active targeting delivery of the drug to the hepatic fibrosis focus is realized. The nanoparticles have the characteristics of uniform particle size, high encapsulation efficiency and good slow release effect, can significantly improve the enrichment concentration of dihydromyricetin in the liver, enhance the anti-hepatic fibrosis curative effect and reduce the systemic side effects, and have good application prospects in preparation of hepatic fibrosis targeted therapy drugs.

The present invention provides a drug composition containing a metal salt of chondroitin sulfate polysaccharide. [Solution] A drug composition comprising a metal salt of chondroitin sulfate polysaccharide represented by the following general formula (I), wherein the metal salt of chondroitin sulfate polysaccharide has the following structure, TIFF2026071360000018.tif55166 R=H or SO3 - (I) The chondroitin sulfate polysaccharide is electrically neutral overall, contains a chondroitin sulfate polysaccharide anion and a metal cation, the average molecular weight of the anion is 1000 to 15000 Da, and the anion contains -SO3 - to-COO - A drug composition in which the molar ratio of is 1.46 to 2.73, and the range of the anion n is 2 ≤ n ≤ 45.

The invention provides collagen and chondroitin sulfate composite freeze-dried sponge as well as a preparation method and application thereof, and relates to the technical field of freeze-dried sponge. The preparation method comprises the following steps: preparing a composite solution of collagen and chondroitin sulfate, adjusting the pH value of the composite solution to be alkaline, defoaming the composite solution, and incubating the defoamed composite solution at the temperature of 30-40 DEG C to obtain a pretreated sample; wherein the ratio of the concentration of the collagen in the composite solution to the concentration of the chondroitin sulfate is (5-20): 1, and the concentration of the collagen in the composite solution is 15-50 mg / mL; and pre-freezing the pre-treated sample, and sequentially carrying out sublimation drying and desorption drying under a vacuum condition. The problem of cracking of the composite freeze-dried sponge can be improved.

The invention relates to the technical field of polysaccharide substance extraction, in particular to a process optimization method for efficiently removing protein residues in chondroitin sulfate sodium, and the method comprises the following steps: soaking shark cartilage tissues to obtain soaking water; alkali liquor is added into the soaking water, and pretreatment liquid is obtained; neutralizing the pretreatment solution, and performing enzymolysis on the neutralized solution to obtain an initial extracting solution; a model predictive control technology is adopted to control the ultrafiltration membrane filtering process of the initial extracting solution, the extracting solution and the non-extracting solution are arranged on the two sides of an ultrafiltration membrane respectively, and the predictive range in the model predictive control technology is regulated and controlled according to the difference between the two sides of the ultrafiltration membrane. The method solves the interference of abnormal fluctuation of pressure and temperature on the purification process of the sodium chondroitin sulfate, and improves the removal efficiency of residual protein in the sodium chondroitin sulfate and the purification effect of the sodium chondroitin sulfate.

The invention belongs to the field of biological medicine, and particularly relates to a nano-drug based on chondroitin sulfate as well as a preparation method and application of the nano-drug. Chondroitin sulfate (CS) and dasatinib (DAS) are connected through a GFLG connexon responded by cathepsin B (CTSB) to prepare the prodrug CS-GFLG-DAS (CGD), the prodrug CS-GFLG-DAS (CGD) is used for reversing the phenotype of cancer-related fibroblasts and reducing the biosynthesis of extracellular matrixes, fibrotic tumors are efficiently treated, and a new perspective is provided for optimizing the application of immunotherapy in fibrotic tumors.

The invention discloses a composition containing bovine bone collagen as well as a preparation method and application thereof, and belongs to the technical field of collagen application. The composition containing the bovine bone collagen is obtained by chemical crosslinking of bovine bone collagen magnesium chelate, sodium hyaluronate, chondroitin sulfate and bovine bone collagen through EDC / NHS. The composition containing bovine bone collagen is prepared from the following components in parts by weight: 5 to 10 parts of bovine bone collagen magnesium chelate, 2 to 5 parts of sodium hyaluronate, 0.5 to 2 parts of chondroitin sulfate and 20 to 30 parts of bovine bone collagen. The bovine bone collagen magnesium chelate, the sodium hyaluronate, the chondroitin sulfate and the bovine bone collagen in the composition containing the bovine bone collagen prepared by the invention have the characteristics of good biocompatibility, capability of promoting cell proliferation and differentiation into cartilage cells, and suitability for cartilage repair.

The application discloses a SOD-containing patch for gouty arthritis and belongs to the fields of biological medicine and medical devices. The SOD-containing patch for gouty arthritis is prepared by compounding SOD, chondroitin sulfate A sodium salt and chitosan, can reduce the uric acid level to a higher degree, and has a good anti-inflammatory effect and swelling elimination effect. The SOD is wrapped by the chitosan-chondroitin sulfate A sodium salt compound, so that the SOD maintains the enzyme activity in the application process, the utilization rate is effectively improved, the prepared patch has high mechanical strength, the fixing ability of the patch to the joint skin can be maintained in daily activities, and the falling phenomenon does not occur.

The present invention provides an automated method for analyzing and quantifying chondroitin sulfate proteoglycan (CSPG) depletion in processed nerve graft tissue samples.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The invention relates to the technical field of nutritional supplement preparations for pets, in particular to a high-activity non-denatured II-type collagen pet joint dispersible tablet and a preparation method thereof. According to the technical scheme, the soft capsule is prepared from the following raw materials in percentage by weight: 4.0%-7.0% of non-modified II type collagen, 4.0%-6.0% of sodium chondroitin sulfate, 4.0%-6.0% of green lip mussel powder, 0.5%-1.5% of sodium hyaluronate, 30%-40% of microcrystalline cellulose, 12%-18% of sodium carboxymethyl starch, 15%-22% of sweet potato starch, 4.0%-6.0% of polyvinylpolypyrrolidone, 6.0%-10.0% of enzymolysis chicken liver powder, 2.0%-4.0% of yeast extract, 1.5%-3.5% of lactose goat milk powder and 0.3%-0.7% of magnesium stearate. A core active component structure is protected by virtue of nano embedding and a whole-course low-temperature process, and a dual joint maintenance path of immunoregulation and nutrition supplement is constructed.

The invention provides a GSH (glutathione) reduction response type targeted nano-drug based on chondroitin sulfate as well as a preparation method and application of the GSH reduction response type targeted nano-drug. Chondroitin sulfate with CD44 receptor targeting ability and an anti-cancer drug camptothecin are covalently linked through a disulfide bond sensitive to GSH, and the constructed novel targeting nano-drug can accurately recognize human colorectal cancer tumor cells highly expressed by a CD44 receptor in a targeting manner. Meanwhile, the high-concentration glutathione at the tumor site can oxidize and reduce the disulfide bond to cause the fracture of AC-CPT NPs, so that the effective release of the camptothecin medicine at the tumor site is realized, and the anti-tumor effect is further enhanced. The reduction response type targeting nano-drug prepared by the invention solves the problems of poor targeting and biological solubility and limited treatment effect of the traditional anti-cancer drug camptothecin, and provides an innovative strategy for realizing accurate targeting and efficient treatment of cancers.

The invention relates to the technical field of biological engineering, and discloses eggshell membrane powder and a preparation method thereof, and the preparation method comprises the following steps: (1) adopting a fermentation broth of Bacillus licheniformis CICC No: 10092 as an enzyme preparation, and carrying out an enzymatic hydrolysis reaction on eggshells with membranes; (2) after the enzymolysis is finished, performing enzyme deactivation, and filtering enzymatic hydrolysate to obtain supernate; and (3) carrying out spray drying on the supernate, and collecting dried powder, namely the eggshell membrane powder. The preparation method solves the problems of complicated operation, chemical reagent residues, high difficulty in multi-enzyme synergistic regulation and the like in the existing preparation technology of the eggshell membrane powder, and the content of active ingredients such as collagen, hyaluronic acid and chondroitin sulfate in the prepared eggshell membrane powder is equivalent to that in the prior art; and the method has the outstanding advantages of simplified process, greenness, safety and controllable cost.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

The invention discloses a chondroitin-based hydrophilic polysilsesquioxane microsphere and a preparation method thereof, and belongs to the technical field of organic polymers. The technical problem to be solved is to provide the hydrophilic polysilsesquioxane which has good hydrophilicity, physical and chemical stability, good dispersity, good biocompatibility and environmental friendliness. The composition is suitable for the field of skin care products for moisturizing and sunscreen. The key point of the technical scheme is that the preparation method comprises the following steps: S1, preparing a modified silane coupling agent KH560 #: mixing chondroitin, a silane coupling agent and a solvent, reacting to obtain colloid, dialyzing and freeze-drying to obtain the modified silane coupling agent KH560 #; s2, preparing polysilsesquioxane microspheres: mixing the modified silane coupling agent KH560 #, citric acid, methyltrimethoxysilane, a silane coupling agent, a catalyst and a solvent, and reacting to obtain the polysilsesquioxane microspheres.

The invention discloses application of recombinant human glaze matrix protein in skin repair dressing, and belongs to the technical field of biomedicine. The skin repair dressing comprises recombinant human glaze matrix protein, sodium hyaluronate, chondroitin sulfate, osa starch and propylgallate wrapped by lipidosome, and the repair effect is improved through a multiple synergistic mechanism. The preparation method of the dressing comprises the following steps: mixing the recombinant human glaze matrix protein with the stabilizer, and then carrying out homogeneous binding with the sodium hyaluronate, the osa starch, the liposome propyl gallate and the hydrogel matrix. Experiments prove that after the dressing is used, the wound healing speed is increased, the III type collagen secretion amount is increased, the TGF-beta1 expression is reduced, the scar index is reduced, and the dressing is suitable for burn and surgical incision repair.

The present invention discloses a SAMe, 5-HTP, and St. John's wort compound nutritional supplement for emotional support and joint care, comprising 15-25 parts of S-adenosylmethionine, 5-10 parts of 5-hydroxytryptophan, 3-8 parts of St. John's wort extract, 8-15 parts of sodium chondroitin sulfate, 2-5 parts of sodium hyaluronate, 0.5-1.2 parts of vitamin B6, 1-3 parts of vitamin E, 4-9 parts of phosphatidylserine, and pharmaceutical excipients. The weight ratio of S-adenosylmethionine to 5-hydroxytryptophan is 3:1-5:2, the weight ratio of St. John's wort extract to 5-hydroxytryptophan is 0.6:1-0.8:1, and the weight ratio of the joint-care agents to the total core active ingredients is 10:3-20:3. The hypericin content in the St. John's wort extract is not less than 3%. By optimizing the component ratios and utilizing synergistic functional excipients, the present invention achieves dual synergy in emotional support and joint care, with high product stability and excellent bioavailability.