48 results about "Bone strength" patented technology

A method of improving and / or enhancing at least one of bone mineralization, bone strength, bone mass, and bone mineral density in an individual in need thereof, the method comprising administering to the individual a composition comprising one or more anabolic amino acids, and the composition further comprising one or more autophagy-inducing compounds. In one embodiment, the one or more autophagy-inducing compounds are selected from the group consisting of thymol, carvacrol, spermidine, urolithin (e.g., Urolithin A, B or D), rapamycin, Torin1, valproic acid, polyphenols (e.g., resveratrol), caffeine, metformin, 5′ AMP-activated protein kinase (AMPK) activators, L-type calcium channel inhibitors, ketones (e.g. beta-hydroxybutyrate, ketone salts, or ketone ester derivatives), 4,4′-dimethoxychalcone and mixtures thereof.

The invention provides a medicinal and edible composition for preventing and treating osteoporosis and a preparation method thereof. The medicinal and edible composition comprises the following raw materials in parts by weight: 15-24 parts of prepared rehmannia root, 12-15 parts of dogwood, 12-20 parts of Chinese yam, 15-20 parts of astragalus membranaceus, 3-10 parts of angelica sinensis and 10-20 parts of folium cortex eucommiae; the medicinal and edible composition provided by the invention promotes osteoblast differentiation, inhibits osteoclast absorption, regulates bone metabolism balance, increases the maximum load of thighbone, and improves bone density and bone strength by increasing osteoprotegerin and reducing type I collagen C-terminal peptide and tartrate-resistant acid phosphatase. The medicinal and edible composition disclosed by the invention is high in safety, can be developed into medicines, health care products or functional foods, and is applied to prevention and treatment of osteoporosis.

The invention provides application of an FZD4 gene. The FZD4 gene is used for regulating osteogenic differentiation and mineralization of chicken bone marrow mesenchymal stem cells. The FZD4 gene in the chicken bone marrow mesenchymal stem cells is over-expressed and is used for promoting osteogenic differentiation and mineralization of the chicken bone marrow mesenchymal stem cells; or / and the FZD4 gene in the chicken bone marrow mesenchymal stem cells is knocked down to inhibit osteogenic differentiation and mineralization of the chicken bone marrow mesenchymal stem cells; the nucleotide sequence of the coding region of the FZD4 gene is as shown in SEQ ID NO. 1. According to the invention, the positive regulation effect of the FZD4 gene in osteogenic differentiation of chicken bone marrow mesenchymal stem cells is determined for the first time, the blank of a bone regulation mechanism of the poultry FZD4 gene is filled, and a new biological preparation target is provided for prevention and treatment of poultry bone diseases; the FZD4 gene can also be used as a molecular marker for breeding chicken varieties with high bone strength.

The present invention relates to a method for predicting the bone strength of a subject by using a learning model trained with image data, bone mineral density data, and bone strength data of an animal bone. According to the present invention, the method for predicting bone strength on the basis of deep learning enables accurate bone strength to be quickly and conveniently predicted and, further, enables appropriate bone cement, bone graft material and the like to be recommended to a subject on the basis of the predicted bone strength.

The invention relates to human lactoferrin for use in enhancing bone strength and / or bone growth in a subject.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

The invention discloses a compound medicine composition for preventing osteoporosis of middle-aged and elderly people, and belongs to the technical field of medicines. The composition is composed of calcium carbonate, calcium hydrophosphate, magnesium oxide, ferrous fumarate, dipotassium phosphate, manganese sulfate, zinc oxide, copper sulfate and vitamin D. Through scientific compounding of the calcium source, the vitamin D and various trace elements, all the components have a synergistic effect, so that nutrients required by bones can be comprehensively supplemented, the calcium absorption efficiency is improved, the bone metabolism is improved, the bone strength and toughness are enhanced, the osteoporosis of the middle-aged and elderly people is effectively prevented and relieved, the irritation to gastrointestinal tracts is small, the safety is high, the preparation is simple, and the cost is controllable; the composition is suitable for long-term administration of middle-aged and elderly people, and can be widely applied to the fields of food, health care products or medicines for preventing and treating middle-aged and elderly osteoporosis.

The invention provides a composition containing a plant extract and a fishbone extract and application of the composition in bone joint health. The composition can repair cartilage, promote secretion of bone joint lubricating liquid, remove inflammatory cells, inhibit inflammatory factors, delay cartilage degeneration, improve bone mineral density and bone strength, maintain bone mineral density, enhance bone firmness, improve osteoporosis and improve arthritis.

The invention discloses a passive bone strength testing device which comprises a base, an upper end cover and a clamping needle, and the clamping needle bottom of the clamping needle extends to the outside of the base. The sliding piece is arranged in the base; the outer shell is arranged in the upper end cover; the force measuring spring is arranged in the sliding piece and the outer shell; the base is provided with a reading window, the reading window is provided with a plurality of scale points at intervals, and a reading line extending along the outer wall of the sliding piece is arranged at the position, matched with the reading window of the base, of the sliding piece. According to the testing device, a passive mechanical structure is adopted for measuring the bone strength, and postoperative disinfection and repeated utilization of instruments are facilitated; according to the device, the bone strength is obtained by measuring the maximum pressure borne by the bone, and compared with traditional bone mineral density measurement, the bone strength can be reflected more accurately, straightly and standardly.

The invention relates to the use of a microbiota-modulating agent for enhancing bone development and / or bone strength. wherein the microbiota-modulating agent modulates the abundance of one or more bacterial taxa selected from Intestinimonas butyriciproducens, Turicibacter sanguinis, Paraprevotella clara, and Acidaminococcaceae in the gut of the subject.

The present invention provides a combination of a vitamin mixture and an oligosaccharide mixture for use in enhancing bone growth and / or bone strength, for example, in a young child suffering from and / or being suffering from a growth retardation and / or a growth retardation.

The present invention provides a composition comprising Bifidobacterium longum subsp. iuvenis for use in promoting bone growth, enhancing bone growth and / or bone strength, for example in a young child who has suffered from and / or is suffering from stunted growth and / or faltering growth.

The application belongs to the technical field of intelligent medical treatment, and provides an orthopedic reduction robot force-position sensing self-adaptive regulation method. The method constructs a three-dimensional model of a diseased side bone containing a bone strength parameter, a healthy side mirror model, and a personalized soft tissue mechanics model containing muscles and ligaments through preoperative CT and MRI multi-modal images. In combination with an expert reduction template and a reinforcement learning algorithm, an initial reduction path and parameters are generated in combination with force and position as dual targets, and a full closed-loop control is formed through an adaptive regulation network by fusing real-time force and position data with preoperative mechanics parameters, so that the upper limit of mechanical arm movement and force control is dynamically adjusted, reduction is completed when a preset accuracy is reached, automatic connection from preoperative planning to intraoperative execution is realized, and the mechanical arm can independently complete the reduction operation according to real-time regulation instructions without frequent manual path correction by the doctor.

The invention discloses an application of 6-CEPN in preparation of a product for preventing and improving osteoporosis. According to the invention, ovariectomized mice are fed with two doses of 6-CEPN, which discovers that the 6-CEPN can obviously inhibit abnormal weight increase of the mice caused by estrogen decrease and can also improve bone microstructure of the ovariectomized mice; the bone trabecula network structure is adjusted by increasing the bone trabecula connection density, the bone trabecula number and the bone trabecula thickness and reducing the separation degree of the bone trabecula, meanwhile, 6-CEPN can further increase the bone density and the bone volume fraction of ovariectomized mice, increase the rigidity and deflection of bones and improve the bone strength, the effect of high-dose 6-CEPN is larger than that of low-dose 6-CEPN, and the effect of high-dose 6-CEPN is better than that of low-dose 6-CEPN. Therefore, the composition has a dose-dependent effect.

The present invention provides compositions and methods for improving bone formation, bone mass, and / or bone strength, and / or treating or preventing bone loss, such as age-related bone loss, in a subject in need of such treatment. Such compositions comprise a homopolysaccharide, or a pharmaceutically acceptable ester or salt thereof, or a pharmaceutically acceptable solvate thereof, or any combination thereof, and a pharmaceutically acceptable excipient. The homopolysaccharide is composed primarily of arabinose, galactose, rhamnose, and galacturonic acid as monomer units. Such methods comprise administering an effective amount of such a composition to a subject in need thereof.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating rheumatoid arthritis inflammation and bone destruction as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials: sabia japonica, fructus psoraleae, rhizoma drynariae, angelica sinensis and herba epimedii. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) carrying out alcohol extraction on sabia japonica and rhizoma drynariae to obtain an alcohol extract and medicine residues; (2) performing water extraction on the medicine residues and other raw materials to obtain a water extract; and (3) combining the alcohol extract and the water extract to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared by performing alcohol extraction on sabia japonica and rhizoma drynariae, performing water extraction on decoction dregs of the sabia japonica and the rhizoma drynariae and other raw materials, and merging an alcohol extract and a water extract, and experiments prove that compared with the prior art, the traditional Chinese medicine composition has better effects on inhibiting bone mass loss around inflammatory joints, improving osteoporosis and enhancing bone strength, and has a good application prospect. The traditional Chinese medicine composition has a better curative effect on rheumatoid arthritis bone destruction.

The invention relates to a liquid pharmaceutical composition comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. Furthermore, it relates to a method of reducing the precipitation of an antibody or antigen-binding fragment thereof in a liquid pharmaceutical composition by adding methionine and cyclodextrin. Specifically. the liquid pharmaceutical composition comprises an anti-sclerostin antibody, hydroxypropyl-γ-cyclodextrin and methionine and can be used in the treatment of a bone disorder associated with at least one of the following: low bone formation, low bone density, low bone mineral content, low bone mass. low bone quality and low bone strength, and especially in the treatment of osteoporosis.Furthermore, the invention relates to a method of reducing injection site inflammation in a mammalian subject comprising administering a therapeutically effective amount of a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine.

Methods and compositions for promoting bone growth, enhancing bone growth and / or bone strength in an infant, young child or child in need thereof, the composition comprising a low sugar, low lactose, milk-based composition comprising galactooligosaccharide (GOS).

The present invention relates to a method for predicting the bone strength of a subject by using a learning model trained with image data, bone mineral density data, and bone strength data of an animal bone. According to the present invention, the method for predicting bone strength on the basis of deep learning enables accurate bone strength to be quickly and conveniently predicted and, further, enables appropriate bone cement, bone graft material and the like to be recommended to a subject on the basis of the predicted bone strength.

The invention provides an FDP composition and application thereof in the aspects of rapidly relieving fatigue and improving bone joint health. The composition can improve absorption and utilization of calcium in vivo, regulate calcium metabolism, promote bone growth, repair cartilage, improve osteoporosis and arthritis, improve bone mineral density and bone strength, maintain bone mineral density and enhance bone firmness; meanwhile, fatigue can be quickly eliminated, weakness, waist soreness, back pain and other symptoms can be relieved, and the body performance is improved.

The present invention provides a combination of vitamin mixtures and synbiotics for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or developmental delay.

The invention provides a composition containing silicon and calcium and application of the composition in the aspects of enhancing calcium absorption, promoting bone collagen formation, repairing cartilage, increasing bone toughness, improving osteoporosis, improving arthritis, improving bone mineral density and bone strength and relieving leg pain and cramp. The composition can achieve a synergistic effect, significantly promote absorption, utilization and conversion of calcium by a human body, enhance calcium absorption, improve calcium absorption rate, promote bone collagen formation, increase bone toughness and relieve leg pain and cramp.

The invention provides traditional Chinese medicine bone-strengthening granules and relates to the field of traditional Chinese medicine granules. The traditional Chinese medicine bone-strengthening granules are specifically prepared from the following raw materials in parts by weight: 60-80 parts of deer blood, 50-70 parts of agkistrodon halys, 110-200 parts of papaya, 5-20 parts of clove, 3-15 parts of liquorice, 10-30 parts of red dates, 5-10 parts of lemon, 6-8 parts of stevioside and a proper amount of milk mineral salt. The bone-strengthening granules are prepared by freeze-drying, concentrating and granulating authentic medicinal materials, and the bone-strengthening granules are prepared by selecting a plurality of medicinal and edible traditional Chinese medicinal materials and extracting through scientific compatibility and a special process, so that the bone-strengthening granules aim to help to improve the health condition of bones, enhance the strength of the bones and reduce the risk of various bone diseases such as osteoporosis.

A bone strength simulation calculation method and device, and a storage medium. The bone strength simulation calculation method includes acquiring three-dimensional data of cancellous bone of a bone segment to be analyzed; obtaining a skeleton mechanical model according to the three-dimensional data; and performing feature analysis on the skeleton mechanical model to obtain skeleton strength data.

The present application relates to a kind of stainless steel powder self-developing bone cement and preparation method, bone cement is composed of two parts of powder and liquid, the ratio of powder and liquid is (2-3):1 g / mL;The component and mass percentage of powder are as follows:50-95% of methyl methacrylate polymer, 5-50% of 430 type ferrite-mannitol compound;Methyl methacrylate polymer contains benzoyl peroxide, and the mass percentage of benzoyl peroxide is 1-5%;The component and mass percentage of liquid are as follows:94.90-99.89% of methyl methacrylate monomer, 0.1-5% of N, N dimethyl-p-toluidine, 0.01-0.1% of hydroquinone.The present application can effectively improve the uniformity of bone cement developing and magnetic heat effect, magnetic heat temperature rate is fast, long-term stable development can be realized, and its mechanical strength and bone strength are approximately matched.

The present invention relates to a bone cement composition comprising polymethylmethacrylate (PMMA) and microbeads, wherein the polymethylmethacrylate and the microbeads satisfy the following conditions: 0.0014x2-0.0221x+0.1816 ≤ P / M ≤ 0.0014x2-0.0165x+2.243 (P is the weight (g) of the polymethylmethacrylate, M is the weight (g) of the microbeads, and x is the bone strength value and in the range of 1.5 to 45). According to the present invention, it is possible to determine a mixing ratio of polymethylmethacrylate and microbeads for providing a bone strength-customized bone cement composition having mechanical properties (strength) similar to the bone strength of a subject to whom bone cement is to be applied. Accordingly, the prepared bone cement composition and bone cement can provide immediate treatment effects when applied to a subject to whom bone cement is to be applied.

This invention relates to the field of fracture risk prediction technology, and particularly to a method and system for constructing a fracture risk prediction model for diabetic osteoporosis. The method involves collecting bone metabolism data and hip and spine bone density computed tomography images from diabetic patients to construct a multi-dimensional three-dimensional model of bone tissue microstructure. Based on this model, blood glucose fluctuation-bone strength mapping is performed to calculate the trabecular fragility increment and identify the pre-gradient feedback characteristics of brittle mechanical signals to obtain brittle mechanical pre-gradient feedback data. Phase shift analysis of bone stress signals is then performed on the above data to extract phase shift feature data and construct a fracture risk prediction model for diabetic osteoporosis. Finally, dynamic assessment and remote monitoring of the patient's fracture risk are conducted. This method integrates three-dimensional bone microstructure modeling, blood glucose fluctuation impact analysis, and artificial intelligence prediction, improving the early warning accuracy of diabetic osteoporotic fractures.

The application discloses application of black corn polysaccharide in preparation of a medicine for preventing or treating senile osteoporosis. The evaluation of the prevention or treatment effect of the black corn polysaccharide on senile osteoporosis includes improvement effects on serum bone metabolism markers, bone microstructure and bone biomechanics. The black corn polysaccharide of the application refers to a polysaccharide powder after water extraction, alcohol precipitation, Sevag method deproteinization, H2O2 method depigmentation and dialysis bag dialysis from dried black corn kernels. The black corn polysaccharide has improvement effects on imbalance of serum bone metabolism markers of senile osteoporosis, deterioration of bone microstructure and decrease of bone strength. The results show that the black corn polysaccharide has great improvement effects on bone loss in preventing senile osteoporosis. Therefore, the black corn polysaccharide has important significance in developing senile osteoporosis in clinic.

The invention discloses a bone source factor gel candy for promoting skeletal development of children and a preparation method thereof, and relates to the technical field of food and gel candies, the bone source factor gel candy comprises a gelling agent, a moisturizing and sweetening agent, a protein and peptide additive, a mineral substance and calcium source additive, a functional additive, and a seasoning and appearance additive, vitamin D metabolism-related pathway activity is indirectly improved by increasing the dosage of the hydrolyzed yolk powder, vitamin D3 is not directly added, pumpkin seeds are newly added to serve as a magnesium source, magnesium element is provided, phytosterol and other synergistic components are contained, overall metabolic regulation is facilitated, osteoblast functions are synergistically promoted, bone resorption is inhibited, and the effect of promoting osteogenesis is achieved. The traditional Chinese medicine composition can effectively promote osteocyte proliferation and differentiation, inhibit osteoclast activity, jointly promote osteoblast activity, enhance bone mineralization process, improve bone mineral density and bone strength, effectively support growth and development of children's bones and increase bone mineral density and bone strength, and can effectively promote osteocyte proliferation and differentiation, inhibit osteoclast activity, improve bone mineral density and bone strength.

This invention relates to a bone cement composition, characterized in that: as a bone cement composition comprising polymethyl methacrylate (PMMA) and microbeads, the mixing ratio of said PMMA and microbeads satisfies 0.0014x 2 ‑0.0221x+0.1816≤P / M≤0.0014x 2 -0.0165x + 2.243 (P is the weight (g) of polymethyl methacrylate, M is the weight (g) of microbeads, and x is the bone strength value, ranging from 1.5 to 45). According to the present invention, the mixing ratio of polymethyl methacrylate and microbeads for providing a customized bone cement composition with bone strength and mechanical properties (strength) similar to those of the bone cement recipient can be determined. Therefore, when the prepared bone cement composition and bone cement are applied to the bone cement recipient, a rapid therapeutic effect can be achieved.