394 results about "Bone growth" patented technology

The invention provides a tripeptide for promoting bone growth, the tripeptide is VPF, the amino acid sequence of the tripeptide is Val-Pro-Phe, the molecular weight of the tripeptide is 361.44 Da, and the tripeptide belongs to the technical field of functional bioactive peptides. The tripeptide can be prepared from egg yolk protein through enzymolysis separation and purification, can also be obtained through chemical solid-phase synthesis, has a good effect of promoting bone growth, can remarkably improve the growth and proliferation level of osteoblasts in a body, promotes synthesis and secretion of bone matrixes, and has a good application prospect. Meanwhile, the secretion of insulin-like growth factors (IGF-1), transforming growth factors (TGF-beta1) and I-type procollagen amino-terminal peptide (PINP) in the body is efficiently promoted, and good market prospects are achieved.

The invention discloses hydrolyzed egg yolk powder rich in growth factor-like polypeptide and a preparation method and application thereof, relates to the technical field of biology and the field of nutrition and health, and particularly relates to the hydrolyzed egg yolk powder rich in growth factor-like polypeptide and application of the hydrolyzed egg yolk powder as a medicament for promoting bone growth. The hydrolyzed egg yolk powder is extracted from egg yolk through a specific enzymolysis technology, and is rich in growth factor-like polypeptides with a remarkable osteogenesis promoting function. The hydrolyzed egg yolk powder and the growth factor-like polypeptide can be used as food additives or medicine components, can effectively promote bone growth, and have remarkable effects on treating or preventing bone health related diseases such as osteogenesis imperfecta, osteoporosis and arthrosis deformans.

The invention provides an application of bifidobacterium animalis subsp. Lactis CP-9 in preparation of a product for promoting bone growth and development or improving bone health. Long-term research and a large number of experiments show that the bifidobacterium animalis subsp. Lactis CP-9 can improve the bone volume fraction, the bone trabecula thickness, the bone density and the bone volume of an organism, and can also effectively improve the growth hormone level and the insulin-like growth factor 1 level, so that bone growth and development are promoted. Meanwhile, the bifidobacterium animalis subsp. Lactis CP-9 can effectively improve the N-terminal propeptide level, osteocalcin level, bone morphogenetic protein level and osteoprotectin level of I-type procollagen in a body, and remarkably reduce the amino-terminal peptide level of the I-type collagen and the ligand level of nuclear factor kappa B receptor activating factor, so that osteoblast differentiation is promoted, osteoclast differentiation is inhibited, and osteoclast differentiation is inhibited. Furthermore, bone formation is promoted, bone resorption is inhibited, bone metabolism is improved, and finally the effect of improving bone health is achieved.

The invention provides a tetrapeptide for promoting bone growth, the amino acid sequence of the tetrapeptide is Glu-Pro-Gly-Phe (EPGF), the molecular weight of the tetrapeptide is 448.48 Da, the tetrapeptide can be prepared from egg yolk protein through protease enzymolysis, separation and purification and can also be obtained through chemical solid-phase synthesis, and the tetrapeptide belongs to the technical field of functional bioactive peptides. The tetrapeptide prepared by the invention can promote the growth of osteoblasts in a body and improve the secretion level of insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1) and I-type procollagen amino terminal peptide (PINP) in cells, so that the effect of promoting bone growth is achieved, and a new functional component is provided for a product for improving bone growth.

The invention belongs to the field of medicines, foods and health-care products, and particularly relates to an accelerant with a bone growth effect and application of the accelerant in the fields of medicines, health-care foods and functional foods. According to the application disclosed by the invention, the inhibiting effect of the morurin on osteogenesis promoting and osteoporosis resisting marker post target osteosclerosis protein is found through high-throughput virtual screening for the first time and is verified through experiments; meanwhile, in-vitro and animal experiments prove the osteogenic differentiation promoting effect of the morusin for the first time. According to the present invention, the morusin and the pharmaceutically acceptable salt thereof can be adopted as the bone growth promoter, can be singly or jointly used, can be used for promoting bone growth and resisting osteoporosis, and can be used in the forms of drugs, health-care foods, functional foods, food additives and the like.

To provide an apparatus for the treatment or prevention of osteopenia and osteoporosis, stimulating bone growth, preserving or improving bone density, and inhibiting adipogenesis.SOLUTION: A vibration apparatus for treating a subject comprises an actuator configured to generate vibrational energy, a securing mechanism for positioning the actuator upon the body of the subject while maintaining portability of the actuator such that the vibrational energy is directed into an area of the body to be treated, an accelerometer disposed along the securing mechanism, and a controller in communication with the actuator and the accelerometer. The controller is programmed to measure an exposure level of the vibrational energy to the area of the body using acceleration acquired from the accelerometer, and to compare the exposure level with a maximum exposure level such that the exposure level is limited by the maximum exposure level within a predetermined period of time.SELECTED DRAWING: Figure 1

The invention discloses an integrated growth and development evaluation management system for children, and particularly relates to the technical field of growth and development evaluation. Child growth and development stages are divided through child physiological parameter collection and dynamic time sequence analysis based on machine learning; processing the child limb proportion time sequence data by using a dynamic time warping algorithm, and evaluating the synchronism of bone growth and soft tissue development; identifying whether the children have development deviation risks or not according to the growth and development stages and synchronism; for children with development deviation risks, combining gene information, and adopting a genetic algorithm and a dynamic programming model to evaluate the growth potential of children individuals; according to the method, the synchronism of child bone growth and soft tissue development and child individual growth potential and development adaptability are subjected to correlation analysis, the probability of potential development abnormality is evaluated, whether personalized intervention measures are started or not is judged, comprehensive monitoring and risk early warning of child growth and development states are achieved, and scientificity and practicability are achieved.

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention relates to the technical field of yak milk powder, and discloses yak milk powder helpful for promoting bone growth and development. Comprising the following specific raw materials: basic raw materials: raw yak milk, dried skim milk, cattle spleen peptide powder, colostrum powder, hydrolyzed yolk powder, phosphatidylserine, N-acetylneuraminic acid, colostrum basic protein, lactoferrin, docosahexaenoic acid, arachidonic acid, xanthophyll and choline; the polypeptide combination comprises Chinese yam peptide powder, poria cocos peptide powder, hawthorn peptide powder, endothelium corneum gigeriae galli peptide powder, walnut peptide and yak bone peptide. Through polypeptide combination of colostrum basic protein and composite mineral supplement, digestion and absorption of children to yak milk powder are promoted, various mineral substances needed by the body are supplemented, immunity is enhanced, bone growth is promoted, multivitamins needed by the body are supplemented by multivitamins, growth and development are promoted, bone growth is indirectly supported, and the yak milk powder has the effects of improving the immunity and improving the immunity. The requirements of children on the key nutrients in the bone growth and development stage are met.

To provide a new composition consisting of 100% natural matter, exerting a therapeutic or beneficial effect in the treatment of bone fragility, having a physiological mode of action.SOLUTION: The present invention provides a 100% natural product consisting of natural matrices exhibiting emerging properties, which enables re-establishing correct bone metabolism by correcting behavior of mesenchymal stem cells and re-establishing a correct balance between cell populations that allow bone growth or remodeling. The natural product consists of, for example, Equisetum flowering tops, Acacia, Malpighia fruit, coral skeleton, avian eggshell, Agave leaves, Cetraria stems, Agaricus, and calcium citrate.SELECTED DRAWING: None

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

The invention discloses a conductive hydrogel for promoting bone growth and a preparation method and application thereof.The preparation method comprises the steps that 1, a methacrylic anhydride gelatin hydrogel prepolymer solution is prepared, a photoinitiator is dissolved in deionized water, and a solution with the mass-volume concentration of 0.003-0.005 g / mL is prepared; methylacrylic anhydride gelatin Gelma is dissolved in the solution, and a methylacrylic anhydride gelatin hydrogel prepolymerization solution is prepared; (2) preparing a CuNPs dispersion liquid; (3) preparation of photo-crosslinking hydrogel: mixing the methylacrylic anhydride gelatin prepolymerization liquid and the CuNPs dispersion liquid to prepare a methylacrylic anhydride gelatin copper nanoparticle conductive hydrogel mixed liquid; in the mixed solution, the massic volume concentration of the methacrylic anhydride gelatin is kept at 0.05 g / mL, the concentration of the copper nanoparticles is 10 mmol / L-40 mmol / L, bubbles are removed, the mixed solution is added into a mold, ultraviolet irradiation is performed, and the photo-crosslinking hydrogel can be prepared. The gel has good conductivity, pore structure, biocompatibility and mechanical property, and has a good osteogenesis promoting effect. The preparation process is simple, and the repeatability is high.

The present invention provides a method for preparing a keratinized gingival repair scaffold, wherein the active powder of biological microspheres is dispersed in a protein slurry to obtain a loose surface stock solution, which is freeze-dried together with a cell-free matrix material, and after two cross-linkings, a keratinized gingival repair scaffold with a loose surface and a dense surface is obtained. When in use, the loose surface of the porous sponge structure contacts the wound surface, which is conducive to the attachment and growth of tissue cells, and the dense surface can seal and protect the wound to a certain extent in an open healing environment. The obtained keratinized gingival repair scaffold can effectively maintain and regulate the pH environment in the oral cavity, inhibit bacteria and resist bacteria, and inhibit the growth of acid-producing bacteria such as Streptococcus mutans and bacteria with strong caries-causing properties, and at the same time has the ability to stop bleeding, promote bone growth and periodontal ligament regeneration, and inhibit periodontal epithelial regression.

A sacroiliac (SI) joint implant assembly addresses SI joint dysfunction and degenerative sacroiliitis. The assembly includes a first implant body, a second implant body, and a piezoelectric layer positioned between them. The piezoelectric layer generates electrical charges when subjected to mechanical stress, stimulating bone growth and enhancing stability of the SI joint after surgery. The implant bodies may feature non-planar surfaces to distribute compressive and shear forces unevenly across the piezoelectric layer. The assembly can be secured using fasteners such as screws, pins, or brackets, and may include porous or fenestrated bodies made from materials like titanium or polymers. Some implant assemblies are designed for minimally invasive surgical procedures, with configurations that allow for precise placement using guide wires and imaging techniques. The assembly aims to stabilize the SI joint and promote bone fusion, leveraging the piezoelectric effect to improve the overall efficacy of the fusion procedure.

The invention provides a tibial prosthesis which comprises a tibial platform provided with a containing groove and a communicating groove, the containing groove is communicated with the upper surface of the tibial platform, and the communicating groove is communicated with the groove bottom wall of the containing groove and the lower surface of the tibial platform; the gasket structure is arranged in the containing groove in a floating mode in the vertical direction; the bone growth body is connected to the lower portion of the gasket structure and located in the communicating groove, and the gasket structure can drive the bone growth body to penetrate out of the tibial plateau downwards when floating in the vertical direction. According to the technical scheme, the problem that in the prior art, the time needed for combining the sclerotin and the prosthesis of a patient is long can be effectively solved.

The invention discloses a composition for promoting skeletal growth and physical development of children and a preparation method, the composition comprises a plurality of nutrient elements and Chinese herbal medicine components, and the components have the effects of promoting skeletal health, enhancing immunity, improving nutrient absorption, regulating metabolism, improving sleep quality, promoting secretion of growth hormone and the like. The healthy growth of bones and the overall development of a body are jointly promoted.

The invention discloses nutrition powder for promoting growth of bones of children and a preparation method of the nutrition powder. The nutrition powder comprises trehalose, strawberry fruit powder, L-calcium lactate, maltodextrin, gamma-aminobutyric acid, L-lysine, taurine, bone collagen, zinc gluconate, fructo-oligosaccharide, Chinese yam powder, poria cocos powder, stevioside, VD3 dry powder and VA acetate powder. The trehalose is used for providing energy needed by growth of children, the gamma-aminobutyric acid and the zinc gluconate have the function of promoting pituitary to secrete growth hormone, the L-calcium lactate and the vitamin D3 are used for providing a calcium source needed by growth and ensuring absorption, and the bone collagen is used for providing a protein source for bone production. Chinese yam, poria cocos and fructo-oligosaccharide which are homologous in medicine and food improve the gastrointestinal absorption function of children, the whole formula is comprehensive in consideration and reasonable in nutrition matching, the purpose of promoting bone growth of children is effectively achieved, and the food has the advantages of being low in production cost, easy and convenient to operate, safe to eat and scientific and reasonable in process.

The invention provides a degradable orthopedic screw in-situ replacer, and belongs to the technical field of orthopedic screw replacement. Comprising a replacement screw, a screw rod and a screw cap, the screw rod and the screw cap form the replacement screw, a hollow cavity is formed in the center of the replacement screw, a rapid dissolving supporting mechanism is fixedly embedded in the hollow cavity, a thread part is arranged at one end of the screw rod, and a dissolving groove communicated with the hollow cavity is formed in the other end of the screw rod; a mounting groove extending into the screw rod is formed in the side wall of the nut, an anti-falling piece is fixedly embedded in the mounting groove, the replacement screw comprises a magnesium alloy base material and a degradable outer-layer coating film fixed to the outer side of the magnesium alloy base material, and a stearic acid lipophilic layer is arranged between the magnesium alloy base material and the degradable outer-layer coating film. And a magnesium oxide layer is arranged on the outer side of the degradable outer coating film. The dissolution speed of the replacement screw in the human body is increased, and the problem that the dissolution speed of the replacement screw is too low, so that bone growth is affected is solved.

The invention discloses a vehicle-mounted portable clinical fixing device for limb fracture, and belongs to the field of medical instruments. Comprising two fixing frames, an open groove is formed in the middle of the outer surface of each fixing frame, locking plates are evenly arranged at the edge of one end of each fixing frame, and clamping assemblies used for fixing legs are connected to the positions, close to the edges, of the two sides of the outer surface of each fixing frame; by arranging the clamping assembly, the fixing area can be flexibly adjusted, long-term pressing of the skin in the local area is avoided, the conditions of extravasated blood, bruise and even pressure sores caused by unsmooth blood are reduced, and the comfort of the fixing device is effectively improved. And moreover, the third gear is not meshed with the second gear and the fourth gear when not in use, so that the situation that the clamping plate and the rectangular frame move, the clamping effect is affected, and even the bone growth is affected due to rotation of the third gear caused by accidental rotation of the driving shaft can be effectively avoided.

The invention discloses a dental implant containing a bioactive surface and a preparation method of the dental implant, relates to the technical field of implants, and aims to improve the biological activity of the dental implant, perform multiple treatments on the surface of the dental implant, and form a microcosmic concave structure on the surface of the implant through sand blasting and laser etching to induce bone growth. Acid liquor and alkali liquor are used for treating the surface of the implant, active hydroxyl is introduced to the surface of the implant, the surface hydrophilicity is improved, and the reaction activity of subsequent reaction steps is improved; then, polyether-ether-ketone with antibacterial performance and hydroxyapatite with biological activity are further introduced into the surface of the dental implant, so that the biological activity of the dental implant is effectively improved.

The invention relates to the technical field of orthopaedic implants, and discloses a children type multistage balloon extendable prosthesis which comprises a near-end prosthesis, a far-end prosthesis, a middle section extension module and a liquid injection channel penetrating through the near-end prosthesis, the far-end prosthesis and the middle section extension module. Three stages of saccules which are connected in series in the axial direction are arranged in the middle section extension module and comprise a near-end saccule, a middle saccule and a far-end saccule, and every two adjacent saccules are connected in a sealed mode through a flexible connecting section; the liquid injection channel is communicated with an inner cavity of the third-stage balloon, and the near end of the liquid injection channel extends to the in-vitro interface; a mechanical locking structure is arranged at the joint of the near-end prosthesis and the middle section extension module; a pressure sensing module is embedded in the bottom of the far-end balloon, monitors the internal pressure of the balloon in real time and is connected with an external terminal. The three-stage balloons are connected in series and matched with the one-way pressure valve, so that grading and small-amplitude precise extension can be achieved, and the growth rhythm of children's bones is matched.

A microcirculation reconstruction bone implant capable of generating internal stress comprises a support shell and a support inner core. The support inner core is sleeved with the support shell, and the support shell and the support inner core form a matched structure. The stent shell is located between the bone tissue and the stent inner core, and the stent shell generates elastic deformation to generate internal stress and applies the internal stress to the surrounding bone tissue when the stent is implanted and loaded; a microcirculation reconstruction passage is also loaded on the stent inner core; by adopting a mode that the stent inner core is matched with the stent shell, the stent inner core is matched with the stent shell to form an elastic effect, so that internal stress can be continuously applied to bone tissues in postoperative application to promote bone growth and integration; and a complex stress environment can be adaptively adjusted, so that the stress compatibility between the implant and a bone tissue is ensured, new intraosseous circulation is established, and the postoperative healing effect after the implant is applied is promoted.

A system and method for altering bone growth on and within an orthopedic implant that includes an implant body; a plurality of electrodes, wherein each electrode is at least partially embedded in the implant body, and comprises: a set of primary electrodes comprising at least one electrode, wherein a non-embedded segment of each primary electrode is proximal to a bone growth region, a set of secondary electrodes comprising at least one electrode, wherein a non-embedded segment of each secondary electrode is distal to the bone growth region, and wherein the plurality of electrodes are configured to function in a stimulation operating mode, such that a subset of primary electrodes function as cathodes and a subset of secondary electrodes function as anodes; a control system comprising a processor, and circuitry that connects to the plurality of electrodes; and a power system.

An adjustable implant system configured to non-invasively guide bone growth in a patient. The adjustable implant system includes a tether having a first end coupled to a fixed bone anchor and a second end coupled to an adjustable bone anchor. The adjustable bone anchor includes a driver disposed within a housing and the driver is configured to actuate in response to an externally applied magnetic field. The adjustable implant system includes an external adjustment device configured to non-invasively actuate the driver disposed within the adjustable bone anchor. Non-invasive actuation of the driver can cause the adjustable bone anchor to increase or decrease the amount of tension on the tether.

The spine implant comprises a frame body and a porous structure, the frame body comprises a first end and a second end which are opposite to each other, a cavity is formed in the frame body, and the cavity penetrates through the frame body in the direction from the first end to the second end; the porous structure comprises a first porous part, the first porous part is contained in the cavity and connected with the frame body, the first porous part comprises a first part, a second part and a third part which are sequentially distributed from the first end to the second end, and the porosity of the first part and the porosity of the third part are both larger than the porosity of the second part. According to the embodiment of the invention, the first part, the second part and the third part of the porous structure of the spine implant are sequentially distributed in the direction from the first end to the second end of the frame body, and the porosity of the first part and the porosity of the third part are greater than that of the second part, so that stress shielding of the spine implant can be reduced; the bone ingrowth performance of the bone is improved, and the risk that the middle of the spine implant is broken is reduced.

An interbody implant can comprise a cage and a porous structure. The cage can comprise an anterior segment, a medial segment, a posterior segment and a lateral segment contiguously connected to each other to define an interior space. The porous structure can be located in the interior space and can be bounded by the cage. The porous structure can comprise opposed superior and inferior surfaces exposed through the cage, an internal cavity located in an interior of the porous structure, and a plurality of ports connecting the internal cavity to the superior and inferior surfaces. A superior-inferior stiffness of the interbody implant can be defined by the porous structure. The porous structure can be compressed within a patient by movement of the spine to biologically stimulate bone growth in vertebrae adjacent the interbody implant. The implant can be configured for lateral, anterior and posterior insertion at different spine levels.

A sacroiliac joint implant includes an implant structure formed from an elongated base member, a forward end structure, an elongated first side member, and an elongated second side member, with an internal support structure extending in an implant plane. A fusion passage is defined in an area between the base member, first side member, and second side member. The fusion passage defines a respective open area through the implant to facilitate bone growth across the sacroiliac joint when the implant is properly implanted in the joint.

The invention discloses sturgeon cartilage active peptide capable of promoting growth and improving bone development as well as a preparation method and application of the sturgeon cartilage active peptide, and belongs to the technical field of active peptide. According to the invention, sturgeon cartilage is taken as a raw material, polypeptide with the highest activity of promoting bone growth and development is selected from different enzymolysis combinations through MC3T3-E1 cell tests, and the positive effect of the polypeptide is verified through zebra fish tests; then, two potential sturgeon cartilage active peptide sequences with the function of promoting bone growth and development are screened out through bioinformatics technologies such as mass spectrum identification, molecular docking and the like, and the amino acid sequences of the sturgeon cartilage active peptide fragments are shown as SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptide prepared by the method disclosed by the invention has the activity of promoting bone growth and development, can solve the problem of high-value utilization of sturgeons, can also be applied to functional products as a functional factor, and has a good application prospect.

An intramedullary bone growth nail device for moving a bone section. The device includes an elongate housing having a first end configured to be secured to a bone section and a second end. The apparatus also includes a drive system positioned within the elongated housing and including a gearbox, a motor, and a controller coupled to the motor. The drive system is mechanically coupled to a delivery mechanism that axially delivers the movable bone section adjacent the elongate housing.

A system and method for spinal fusion that can include: a spinal cage body that includes at least one defined graft window cavity; a plurality of electrodes exposed on the surface of the spinal cage body; control circuitry configured to drive the plurality of electrodes in a stimulation mode; wherein there is at least a targeted osteoinduction region and a targeted non-osteoinduction region that are immediately adjacent to the spinal cage body; and wherein the control circuitry includes configuration to excite the plurality of electrodes during the stimulation mode for generation of a current density in the targeted osteoinduction region and targeted non-osteoinduction region according to targeted levels of bone growth.