148 results about "Bone growth" patented technology

A sacroiliac (SI) joint implant assembly addresses SI joint dysfunction and degenerative sacroiliitis. The assembly includes a first implant body, a second implant body, and a piezoelectric layer positioned between them. The piezoelectric layer generates electrical charges when subjected to mechanical stress, stimulating bone growth and enhancing stability of the SI joint after surgery. The implant bodies may feature non-planar surfaces to distribute compressive and shear forces unevenly across the piezoelectric layer. The assembly can be secured using fasteners such as screws, pins, or brackets, and may include porous or fenestrated bodies made from materials like titanium or polymers. Some implant assemblies are designed for minimally invasive surgical procedures, with configurations that allow for precise placement using guide wires and imaging techniques. The assembly aims to stabilize the SI joint and promote bone fusion, leveraging the piezoelectric effect to improve the overall efficacy of the fusion procedure.

The invention provides a tibial prosthesis which comprises a tibial platform provided with a containing groove and a communicating groove, the containing groove is communicated with the upper surface of the tibial platform, and the communicating groove is communicated with the groove bottom wall of the containing groove and the lower surface of the tibial platform; the gasket structure is arranged in the containing groove in a floating mode in the vertical direction; the bone growth body is connected to the lower portion of the gasket structure and located in the communicating groove, and the gasket structure can drive the bone growth body to penetrate out of the tibial plateau downwards when floating in the vertical direction. According to the technical scheme, the problem that in the prior art, the time needed for combining the sclerotin and the prosthesis of a patient is long can be effectively solved.

The invention discloses a dental implant containing a bioactive surface and a preparation method of the dental implant, relates to the technical field of implants, and aims to improve the biological activity of the dental implant, perform multiple treatments on the surface of the dental implant, and form a microcosmic concave structure on the surface of the implant through sand blasting and laser etching to induce bone growth. Acid liquor and alkali liquor are used for treating the surface of the implant, active hydroxyl is introduced to the surface of the implant, the surface hydrophilicity is improved, and the reaction activity of subsequent reaction steps is improved; then, polyether-ether-ketone with antibacterial performance and hydroxyapatite with biological activity are further introduced into the surface of the dental implant, so that the biological activity of the dental implant is effectively improved.

An adjustable implant system configured to non-invasively guide bone growth in a patient. The adjustable implant system includes a tether having a first end coupled to a fixed bone anchor and a second end coupled to an adjustable bone anchor. The adjustable bone anchor includes a driver disposed within a housing and the driver is configured to actuate in response to an externally applied magnetic field. The adjustable implant system includes an external adjustment device configured to non-invasively actuate the driver disposed within the adjustable bone anchor. Non-invasive actuation of the driver can cause the adjustable bone anchor to increase or decrease the amount of tension on the tether.

A sacroiliac joint implant includes an implant structure formed from an elongated base member, a forward end structure, an elongated first side member, and an elongated second side member, with an internal support structure extending in an implant plane. A fusion passage is defined in an area between the base member, first side member, and second side member. The fusion passage defines a respective open area through the implant to facilitate bone growth across the sacroiliac joint when the implant is properly implanted in the joint.

An intramedullary bone growth nail device for moving a bone section. The device includes an elongate housing having a first end configured to be secured to a bone section and a second end. The apparatus also includes a drive system positioned within the elongated housing and including a gearbox, a motor, and a controller coupled to the motor. The drive system is mechanically coupled to a delivery mechanism that axially delivers the movable bone section adjacent the elongate housing.

A system and method for spinal fusion that can include: a spinal cage body that includes at least one defined graft window cavity; a plurality of electrodes exposed on the surface of the spinal cage body; control circuitry configured to drive the plurality of electrodes in a stimulation mode; wherein there is at least a targeted osteoinduction region and a targeted non-osteoinduction region that are immediately adjacent to the spinal cage body; and wherein the control circuitry includes configuration to excite the plurality of electrodes during the stimulation mode for generation of a current density in the targeted osteoinduction region and targeted non-osteoinduction region according to targeted levels of bone growth.

The invention provides a mechanical property dynamic prediction method after stent implantation, and the method combines CT image three-dimensional reconstruction, finite element simulation analysis and data-driven modeling to construct a whole-process mapping relation from'stent model structure parameters-new bone growth characteristics-mechanical response '; a training data set is constructed through a large amount of simulation data, a proper analysis method is introduced to establish a prediction model, the performance change trend under different structural designs can be efficiently predicted, stent parameters can be reversely optimized, the individualized adaptability and the function-oriented design capability of the stent are improved, and the method is suitable for large-scale popularization and application. Meanwhile, a complex structure parameter space is covered by combining real bone growth data simulation, and the requirement for rapid optimization design of the stent is met; according to the method, the minimum repetitive unit of the model structure is improved and optimized, and meanwhile, the real growth condition of the new bone tissue is combined, so that the method can be more accurately and truly applied to predicting the mechanical property of the bone tissue in the growth process after the stent is implanted.

A supporting frame for preventing foot drop comprises a heel supporting plate which is horizontally arranged, a sole supporting plate is vertically and fixedly connected to the upper side of the rear end of the heel supporting plate, a heel memory cotton pad is arranged on the upper side of the heel supporting plate, supporting legs are arranged on the rear side of the sole supporting plate, and a sole memory cotton pad is arranged on the front side of the sole supporting plate. And two concave parts are arranged on the front side of the sole memory cotton pad at intervals. An extension rod is sleeved on the inner side of the supporting leg, a plurality of through holes are formed in the extension rod, a threaded hole is formed in one side of the supporting leg, a bolt is screwed in the threaded hole, and the bolt penetrates through one of the plurality of through holes. The heel memory cotton pad and the sole memory cotton pad are elastic, direct contact with bone growth is avoided, pressure injury is reduced, the concave portion of the sole supporting plate can effectively limit the foot of a patient, the functional position of the foot is kept, clinical use is facilitated, and skin conditions can be observed in time for nursing.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The invention relates to the technical field of active peptides, and discloses a yolk-derived active peptide for promoting bone growth and a preparation method thereof. The preparation method comprises the following steps: cleaning, selecting, sterilizing and drying poultry eggs to obtain sterile poultry eggs; performing spray drying on yolk to obtain yolk powder, and performing degreasing treatment to obtain degreased yolk powder; sieving the degreased egg yolk powder, and adding deionized water to obtain a degreased egg yolk powder suspension; adjusting the pH and temperature of the degreased yolk powder suspension, and performing enzymolysis to obtain enzymatic hydrolysate; inactivating the enzymatic hydrolysate for later use; adding calcium lactate and zinc lactate into the enzymatic hydrolysate, adding geobacillus stearothermophilus, and fermenting to obtain fermentation liquor; separating to obtain an active peptide solution. According to the yolk-sourced active peptide for promoting bone growth and the preparation method, the active peptide with small molecular weight is obtained through distributed enzymolysis and fermentation and is easy to absorb, and calcium ions and zinc ions are added during fermentation, so that the active peptide is chelated with metal ions, and growth and bone development are promoted.

The present application relates to femoral stem prosthesis, specifically provides a femoral stem prosthesis with twisted trabecular structure, aims to solve the problem that although the existing femoral stem prosthesis has trabecular porous structure to promote bone growth, but still due to the high material elastic modulus and stress concentration inside the pore, leading to stress shielding effect and trabecular fracture, so it is difficult to effectively prevent long-term loosening of the prosthesis. For this purpose, a femoral stem prosthesis with twisted trabecular structure of the present application comprises a trabecular structure unit arranged on the surface layer of the prosthesis, the shape of the trabecular structure unit is a space net structure, the space net structure is provided with pores, the pores can accommodate new bone, and the space net structure is twisted from the inside of the prosthesis to the surface layer of the prosthesis. The present application introduces the mechanical regulation effect brought by structure twisting by arranging the space net trabecular structure which is twisted continuously from inside to outside on the surface layer of the prosthesis, on the basis of ensuring that the pores can be used for new bone growth and realizing bone-prosthesis biological fixation.

The invention discloses a food therapy height increasing method. The food therapy height increasing method comprises the following raw materials: enzymolysis bone calcium, oyster peptide, vitamin C, beta-carotene and hemin chloride. According to the present invention, the components such as the enzymolysis bone calcium, the oyster peptide, the vitamin C, the beta-carotene, the heme chloride and the like, which are beneficial to bone repair and bone growth and development, are extracted so as to meet the bone growth requirements of teenagers and children; the raw materials are processed and prepared into powder, all the components are prepared into the solid beverage in a mixing mode, and the solid beverage can be taken by adding sugar or honey or other flavors into water when being eaten. In conclusion, the solid beverage is suitable for teenagers and children to eat, different from a traditional food therapy mode, various growth promoting requirements are met, cooking is not needed, and the solid beverage can be taken after being mixed with water and is convenient to eat.

Disclosed are exemplary embodiments of materials for piezoelectric implants. Also disclosed are exemplary methods of poling materials for piezoelectric response for bone growth stimulation. Additional exemplary embodiments are disclosed of piezoelectric implants comprising such materials.

The application discloses a preparation method of egg yolk phospholipid polypeptide which is helpful for bone growth and improvement of brain health, and comprises the following steps: (1) raw material pretreatment to obtain a reaction substrate solution; (2) primary enzymolysis to prepare a primary enzymolysis solution; (3) secondary enzymolysis to prepare a secondary enzymolysis solution; (4) inactivation, the temperature of the secondary enzymolysis solution prepared in the step (3) is adjusted to 85-95 DEG C, and the enzyme is completely inactivated by keeping for 10-15 min; (5) fermentation; (6) post-treatment, the fermentation liquid after the fermentation is kept at 50-60 DEG C for 10-30 min, and then cooling, centrifugation, collection of supernatant, vacuum freeze drying or spray drying of the supernatant are carried out, so that the egg yolk phospholipid polypeptide powder is obtained. The natural compound rich in specific functional peptide segments and phospholipids is prepared through the two-step enzymolysis coupling fermentation process, can effectively promote the growth and development of the bone, significantly improve the learning, memory and cognitive ability, and can significantly promote the proliferation of osteoblasts.

A cervical fusion implant with serrations and radio opaque marking and a method thereof is disclosed The cervical fusion implant is optimized for enhanced spinal stabilization and integration. The cervical spine fusion implant is constructed from polyether ether ketone, known for its exceptional durability and biocompatibility. The implant is designed with a robust body encased in a protective capsule. The design ensures superior structural integrity and functional utility. The implant incorporates a self-stabilizing screw assembly featuring at least four lateral surfaces, each with slits to promote bone growth and integration. Additionally, the anterior surface is equipped with a screw hole for secure fixation using a titanium screw. This combination of features aims to improve spinal stabilization, promote effective fusion, and ensure long-term implant performance. Furthermore, the implants assist to maintain normal cervical curvature of the patient.

The invention discloses an application of a humanized DKK-1 monoclonal antibody in preparation of a medicine for treating osteoporosis. A light chain and a heavy chain of the humanized DKK-1 monoclonal antibody are shown as SEQ ID NO.1-2. The invention further discloses a preparation method of the humanized DKK-1 monoclonal antibody. Animal experiments prove that the humanized DKK-1 monoclonal antibody can remarkably improve the bone mineral density of lumbar vertebrae and tibia of an osteoporosis model mouse and can promote bone growth, and a new treatment scheme is provided for treating osteoporosis.

An orthopedic prosthetic component is provided. The orthopedic prosthetic component comprises a porous three-dimensional structure (100) shaped to be implanted in a patient's body. The porous three-dimensional structure comprises a plurality of unit cells (400). At least one unit cell comprises a first geometric structure having a first geometry and comprising a plurality of first columns (410) and a second geometric structure having a second geometry and comprising a plurality of second columns (420) connected to a number of the plurality of first columns to form the second geometric structure.

The invention relates to human lactoferrin for use in enhancing bone strength and / or bone growth in a subject.

The application discloses a 3D-printed intervertebral fusion cage, which is used to solve the problem of poor bone ingrowth effect of the prior art fusion cage, slow degradation speed, and early release of active ingredients, and the structure comprises a frame and an embedded pipe, the embedded pipe is arranged in the frame, the components are all made of degradable metal materials and can be gradually degraded in the human body, the embedded pipe is further encapsulated with active ingredients for promoting bone growth, and the active ingredients are released with the degradation of the embedded pipe, so that the early release of the drugs in the embedded pipe is avoided, long-acting effect is achieved, and of course a net beam is arranged in the gap of the frame, and the porous structure formed by the net beam further increases the bone ingrowth effect; the application creatively uses a 3D process to realize the encapsulation of the active ingredients and the forming of the porous support, and is combined with the degradable metal to realize the sustained release, so that a good growth condition is provided for the bone ingrowth in the porous support, the effect of the growth factors is fully played, and the treatment effect is improved.

This invention provides a wireless, passive force-position implantable growth monitoring system and its fabrication method for early-onset scoliosis correction. The system includes: a connected compressible capacitive sensor and a flexible wireless antenna coil; the compressible capacitive sensor is connected to a self-growing early-onset scoliosis correction implant growth rod, and the flexible wireless antenna coil is disposed within the body. The compressible capacitive sensor and the flexible wireless antenna coil together constitute an LCR resonant circuit; the compressible capacitive sensor monitors the pressure changes caused by the elongation of the self-growing early-onset scoliosis correction implant growth rod during tissue or bone growth, thereby causing changes in capacitance and resulting in changes in the resonant frequency of the LCR resonant circuit; the resonant frequency change is detected and read out wirelessly via an external readout device. This system is designed to meet the needs of digital rehabilitation, requires no internal power supply, and has a stable structure, making it suitable for growth monitoring after early-onset scoliosis correction surgery.

The present disclosure relates to a composite material for application to a bone defect site to promote new bone growth at the site comprising: a combination of freeze-dried mineralized bone allograft particles; and a monophasic gel comprising cross-linked hyaluronic acid; wherein the hyaluronic acid is cross-linked by a cross-linking agent, the cross-linking agent being a diglycidyl ether. The present disclosure also relates to a method to obtain a composite material for application to a bone defect site to promote new bone growth at the site comprising mixing freeze-dried mineralized bone allograft particles with a monophasic gel comprising hyaluronic acid; and to a bone regenerative material comprising the composite material as defined herein for use in a method of treating a patient suffering from a degenerative bone condition, bone loss, bone deficiency or bone atrophy.

This application discloses a method and its application for preparing collagen peptides by stepwise enzymatic hydrolysis with dynamic pH control, belonging to the field of protein preparation technology. The method includes raw material pretreatment, stepwise enzymatic hydrolysis with dynamic pH control, and post-treatment to obtain collagen peptide products with a molecular weight distribution of 800-2000 Da. The obtained products can be used to prepare products with bone growth promotion functions. This application employs a combined process of stepwise enzymatic hydrolysis with dynamic pH control, alkali-thermal coupling pretreatment, and 2000 Da retention. The steps work synergistically: alkali-thermal treatment exposes enzyme cleavage sites, dynamic pH control enables efficient enzymatic hydrolysis, and 2000 Da retention of active components results in a significantly higher yield and content of collagen peptides compared to conventional processes. Animal experiments have demonstrated that the collagen peptides have bone growth promotion activity, and the mechanism of action has been revealed at the IGF-1 signaling pathway level.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The invention discloses a composite material for oral bone repair and a preparation method and application thereof, and the composite material comprises the following components in parts by mass: 40-60 parts of a polymer matrix and 40-60 parts of a reinforcing filler dispersed in the polymer matrix; wherein the polymer matrix comprises a multi-arm polycaprolactone-lactide copolymer, and the reinforcing filler comprises hydroxyapatite of which the surface is modified with hydrophobic molecules. According to the invention, the composite material for repairing the oral cavity bone, which is moldable and anti-collapsing and has a degradation rate matched with bone growth, and the preparation method and the application of the composite material can be provided.

The utility model relates to the intervertebral fusion cage technical field discloses a kind of anti-drop intervertebral fusion cage. To solve the stress shielding problem in the actual use of conventional intervertebral fusion cage in prior art, and porosity is lower, fusion rate is low after operation;Lack of bone integration channel, the technical problem of low fusion rate after operation. The utility model includes support frame, at least two bone graft channels are arranged on support frame, to fill bone induction material and promote bone growth;Support frame end is provided with clamping groove;Support frame includes edge support part, and edge support part is connected by porous structure between;The porosity of porous structure gradually changes from small to large by the direction close to far from vertebral body, and presents gradient distribution. The utility model effectively balances the problem of insufficient porous structure strength, and the problem of too large solid structure quality, and the porosity of porous structure is large, has more bone integration channel, is conducive to the growth of bone cell, and can effectively improve bone growth rate.

Methods for improving bone growth in a subject are provided. In one aspect, the methods include administering to a subject having a deficiency in bone growth one or more doses of an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof.

The application relates to the field of microbial technology, and particularly discloses a Bifidobacterium adolescentis AGE17 for promoting muscle and bone growth and development and an application thereof. Bifidobacterium adolescentis The Bifidobacterium adolescentis AGE17 is isolated from the feces of healthy children, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 33452 and a preservation date of January 17, 2025. Animal experiments prove that the Bifidobacterium adolescentis strain AGE17 provided by the application has the function of promoting muscle and bone development, has more obvious and prominent effects compared with a model strain Bifidobacterium adolescentis ATCC15703, and has important application values in increasing the muscle strength and height of children and teenagers.

The utility model relates to a kind of 3D printing's embedded titanium-magnesium alloy bone repair body, belong to bone repair body field, solve the existing single titanium alloy bone repair body elastic modulus and human skeleton difference in prior art is larger, it is prone to stress shielding effect, and the single magnesium alloy bone repair body mechanical strength and corrosion resistance is poor.The utility model includes titanium alloy cylinder, magnesium alloy structure and inlay structure, magnesium alloy structure is connected with titanium alloy cylinder by inlay structure;Multiple evenly distributed inlay grooves are equipped along the circumference of titanium alloy cylinder, both sides of inlay groove are equipped with directional slide, magnesium alloy structure is arranged in inlay groove, both sides of magnesium alloy structure are equipped with limit protrusion, limit protrusion and directional slide sliding connection.The utility model inlay magnesium alloy structure in titanium alloy cylinder, rely on titanium alloy cylinder to provide mechanical support, magnesium alloy structure gradually degrades to promote bone growth, the defect of single material is effectively avoided by the combination of both.

Provided is an application of a bone growth promoter using maclurin as an active ingredient in the preparation of drugs, health supplements, and functional foods. As a bone growth promoter, maclurin and a pharmaceutically acceptable salt thereof can be used alone or in combination for promoting bone growth and resisting osteoporosis. The product forms thereof comprise drugs, health supplements, functional foods, food additives, etc.