235 results about "Bone growth" patented technology

The invention provides an application of bifidobacterium animalis subsp. Lactis CP-9 in preparation of a product for promoting bone growth and development or improving bone health. Long-term research and a large number of experiments show that the bifidobacterium animalis subsp. Lactis CP-9 can improve the bone volume fraction, the bone trabecula thickness, the bone density and the bone volume of an organism, and can also effectively improve the growth hormone level and the insulin-like growth factor 1 level, so that bone growth and development are promoted. Meanwhile, the bifidobacterium animalis subsp. Lactis CP-9 can effectively improve the N-terminal propeptide level, osteocalcin level, bone morphogenetic protein level and osteoprotectin level of I-type procollagen in a body, and remarkably reduce the amino-terminal peptide level of the I-type collagen and the ligand level of nuclear factor kappa B receptor activating factor, so that osteoblast differentiation is promoted, osteoclast differentiation is inhibited, and osteoclast differentiation is inhibited. Furthermore, bone formation is promoted, bone resorption is inhibited, bone metabolism is improved, and finally the effect of improving bone health is achieved.

To provide an apparatus for the treatment or prevention of osteopenia and osteoporosis, stimulating bone growth, preserving or improving bone density, and inhibiting adipogenesis.SOLUTION: A vibration apparatus for treating a subject comprises an actuator configured to generate vibrational energy, a securing mechanism for positioning the actuator upon the body of the subject while maintaining portability of the actuator such that the vibrational energy is directed into an area of the body to be treated, an accelerometer disposed along the securing mechanism, and a controller in communication with the actuator and the accelerometer. The controller is programmed to measure an exposure level of the vibrational energy to the area of the body using acceleration acquired from the accelerometer, and to compare the exposure level with a maximum exposure level such that the exposure level is limited by the maximum exposure level within a predetermined period of time.SELECTED DRAWING: Figure 1

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

To provide a new composition consisting of 100% natural matter, exerting a therapeutic or beneficial effect in the treatment of bone fragility, having a physiological mode of action.SOLUTION: The present invention provides a 100% natural product consisting of natural matrices exhibiting emerging properties, which enables re-establishing correct bone metabolism by correcting behavior of mesenchymal stem cells and re-establishing a correct balance between cell populations that allow bone growth or remodeling. The natural product consists of, for example, Equisetum flowering tops, Acacia, Malpighia fruit, coral skeleton, avian eggshell, Agave leaves, Cetraria stems, Agaricus, and calcium citrate.SELECTED DRAWING: None

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

A sacroiliac (SI) joint implant assembly addresses SI joint dysfunction and degenerative sacroiliitis. The assembly includes a first implant body, a second implant body, and a piezoelectric layer positioned between them. The piezoelectric layer generates electrical charges when subjected to mechanical stress, stimulating bone growth and enhancing stability of the SI joint after surgery. The implant bodies may feature non-planar surfaces to distribute compressive and shear forces unevenly across the piezoelectric layer. The assembly can be secured using fasteners such as screws, pins, or brackets, and may include porous or fenestrated bodies made from materials like titanium or polymers. Some implant assemblies are designed for minimally invasive surgical procedures, with configurations that allow for precise placement using guide wires and imaging techniques. The assembly aims to stabilize the SI joint and promote bone fusion, leveraging the piezoelectric effect to improve the overall efficacy of the fusion procedure.

The invention provides a tibial prosthesis which comprises a tibial platform provided with a containing groove and a communicating groove, the containing groove is communicated with the upper surface of the tibial platform, and the communicating groove is communicated with the groove bottom wall of the containing groove and the lower surface of the tibial platform; the gasket structure is arranged in the containing groove in a floating mode in the vertical direction; the bone growth body is connected to the lower portion of the gasket structure and located in the communicating groove, and the gasket structure can drive the bone growth body to penetrate out of the tibial plateau downwards when floating in the vertical direction. According to the technical scheme, the problem that in the prior art, the time needed for combining the sclerotin and the prosthesis of a patient is long can be effectively solved.

The invention discloses a dental implant containing a bioactive surface and a preparation method of the dental implant, relates to the technical field of implants, and aims to improve the biological activity of the dental implant, perform multiple treatments on the surface of the dental implant, and form a microcosmic concave structure on the surface of the implant through sand blasting and laser etching to induce bone growth. Acid liquor and alkali liquor are used for treating the surface of the implant, active hydroxyl is introduced to the surface of the implant, the surface hydrophilicity is improved, and the reaction activity of subsequent reaction steps is improved; then, polyether-ether-ketone with antibacterial performance and hydroxyapatite with biological activity are further introduced into the surface of the dental implant, so that the biological activity of the dental implant is effectively improved.

The invention relates to the technical field of orthopaedic implants, and discloses a children type multistage balloon extendable prosthesis which comprises a near-end prosthesis, a far-end prosthesis, a middle section extension module and a liquid injection channel penetrating through the near-end prosthesis, the far-end prosthesis and the middle section extension module. Three stages of saccules which are connected in series in the axial direction are arranged in the middle section extension module and comprise a near-end saccule, a middle saccule and a far-end saccule, and every two adjacent saccules are connected in a sealed mode through a flexible connecting section; the liquid injection channel is communicated with an inner cavity of the third-stage balloon, and the near end of the liquid injection channel extends to the in-vitro interface; a mechanical locking structure is arranged at the joint of the near-end prosthesis and the middle section extension module; a pressure sensing module is embedded in the bottom of the far-end balloon, monitors the internal pressure of the balloon in real time and is connected with an external terminal. The three-stage balloons are connected in series and matched with the one-way pressure valve, so that grading and small-amplitude precise extension can be achieved, and the growth rhythm of children's bones is matched.

A microcirculation reconstruction bone implant capable of generating internal stress comprises a support shell and a support inner core. The support inner core is sleeved with the support shell, and the support shell and the support inner core form a matched structure. The stent shell is located between the bone tissue and the stent inner core, and the stent shell generates elastic deformation to generate internal stress and applies the internal stress to the surrounding bone tissue when the stent is implanted and loaded; a microcirculation reconstruction passage is also loaded on the stent inner core; by adopting a mode that the stent inner core is matched with the stent shell, the stent inner core is matched with the stent shell to form an elastic effect, so that internal stress can be continuously applied to bone tissues in postoperative application to promote bone growth and integration; and a complex stress environment can be adaptively adjusted, so that the stress compatibility between the implant and a bone tissue is ensured, new intraosseous circulation is established, and the postoperative healing effect after the implant is applied is promoted.

An adjustable implant system configured to non-invasively guide bone growth in a patient. The adjustable implant system includes a tether having a first end coupled to a fixed bone anchor and a second end coupled to an adjustable bone anchor. The adjustable bone anchor includes a driver disposed within a housing and the driver is configured to actuate in response to an externally applied magnetic field. The adjustable implant system includes an external adjustment device configured to non-invasively actuate the driver disposed within the adjustable bone anchor. Non-invasive actuation of the driver can cause the adjustable bone anchor to increase or decrease the amount of tension on the tether.

A sacroiliac joint implant includes an implant structure formed from an elongated base member, a forward end structure, an elongated first side member, and an elongated second side member, with an internal support structure extending in an implant plane. A fusion passage is defined in an area between the base member, first side member, and second side member. The fusion passage defines a respective open area through the implant to facilitate bone growth across the sacroiliac joint when the implant is properly implanted in the joint.

The invention discloses sturgeon cartilage active peptide capable of promoting growth and improving bone development as well as a preparation method and application of the sturgeon cartilage active peptide, and belongs to the technical field of active peptide. According to the invention, sturgeon cartilage is taken as a raw material, polypeptide with the highest activity of promoting bone growth and development is selected from different enzymolysis combinations through MC3T3-E1 cell tests, and the positive effect of the polypeptide is verified through zebra fish tests; then, two potential sturgeon cartilage active peptide sequences with the function of promoting bone growth and development are screened out through bioinformatics technologies such as mass spectrum identification, molecular docking and the like, and the amino acid sequences of the sturgeon cartilage active peptide fragments are shown as SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptide prepared by the method disclosed by the invention has the activity of promoting bone growth and development, can solve the problem of high-value utilization of sturgeons, can also be applied to functional products as a functional factor, and has a good application prospect.

An intramedullary bone growth nail device for moving a bone section. The device includes an elongate housing having a first end configured to be secured to a bone section and a second end. The apparatus also includes a drive system positioned within the elongated housing and including a gearbox, a motor, and a controller coupled to the motor. The drive system is mechanically coupled to a delivery mechanism that axially delivers the movable bone section adjacent the elongate housing.

A system and method for spinal fusion that can include: a spinal cage body that includes at least one defined graft window cavity; a plurality of electrodes exposed on the surface of the spinal cage body; control circuitry configured to drive the plurality of electrodes in a stimulation mode; wherein there is at least a targeted osteoinduction region and a targeted non-osteoinduction region that are immediately adjacent to the spinal cage body; and wherein the control circuitry includes configuration to excite the plurality of electrodes during the stimulation mode for generation of a current density in the targeted osteoinduction region and targeted non-osteoinduction region according to targeted levels of bone growth.

The invention discloses a traditional Chinese medicine activity activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials. The traditional Chinese medicine activity activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial scaffold and a pharmacodynamic filler, according to the invention, Co hollow spheres loaded with carbon nanotubes are cross-linked and compounded with sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets to form an organic-inorganic composite porous antibacterial scaffold, which not only has good mechanical properties and antibacterial properties, but also can stably bear more pharmacodynamic fillers and enable the pharmacodynamic fillers to be slowly released; the stability of the stent structure is further improved through the pharmacodynamic filler, the antibacterial property and the osteogenesis effect of the implant material are remarkably enhanced through the synergistic effect of the pharmacodynamic filler and the stent structure, and the excellent bone repair effect is achieved.

The utility model relates to the technical field of surgical instruments, in particular to a locking bone fracture plate which comprises a bone plate body, a plurality of locking holes used for screws to penetrate through are formed in the bone plate body in the length direction, the locking holes are kidney-shaped holes, an inner support and an outer support are arranged in the locking holes and are arranged in a nested mode, and the outer support and the inner support are connected with each other. The outer support can move in the length direction of the locking hole, the inner support can rotate around the width direction of the locking hole, a screw hole is formed in the inner support, a locking groove communicated with the locking hole is formed in the bone plate body, a locking piece abutting against the inner support and the outer support is arranged in the locking groove, and first springs are symmetrically arranged at the two ends of the outer support in the length direction of the outer support. The outer support is arranged in the middle of the locking hole through a first spring. According to the locking bone fracture plate, the angle of the screw hole is adjusted through cooperation of the inner support and the outer support, then the adjusted inner support and the outer support are pre-positioned through the locking piece, the inner support and the outer support are slightly moved through elastic fixing, and self-adaption can be achieved along with bone growth.

The invention provides a mechanical property dynamic prediction method after stent implantation, and the method combines CT image three-dimensional reconstruction, finite element simulation analysis and data-driven modeling to construct a whole-process mapping relation from'stent model structure parameters-new bone growth characteristics-mechanical response '; a training data set is constructed through a large amount of simulation data, a proper analysis method is introduced to establish a prediction model, the performance change trend under different structural designs can be efficiently predicted, stent parameters can be reversely optimized, the individualized adaptability and the function-oriented design capability of the stent are improved, and the method is suitable for large-scale popularization and application. Meanwhile, a complex structure parameter space is covered by combining real bone growth data simulation, and the requirement for rapid optimization design of the stent is met; according to the method, the minimum repetitive unit of the model structure is improved and optimized, and meanwhile, the real growth condition of the new bone tissue is combined, so that the method can be more accurately and truly applied to predicting the mechanical property of the bone tissue in the growth process after the stent is implanted.

A supporting frame for preventing foot drop comprises a heel supporting plate which is horizontally arranged, a sole supporting plate is vertically and fixedly connected to the upper side of the rear end of the heel supporting plate, a heel memory cotton pad is arranged on the upper side of the heel supporting plate, supporting legs are arranged on the rear side of the sole supporting plate, and a sole memory cotton pad is arranged on the front side of the sole supporting plate. And two concave parts are arranged on the front side of the sole memory cotton pad at intervals. An extension rod is sleeved on the inner side of the supporting leg, a plurality of through holes are formed in the extension rod, a threaded hole is formed in one side of the supporting leg, a bolt is screwed in the threaded hole, and the bolt penetrates through one of the plurality of through holes. The heel memory cotton pad and the sole memory cotton pad are elastic, direct contact with bone growth is avoided, pressure injury is reduced, the concave portion of the sole supporting plate can effectively limit the foot of a patient, the functional position of the foot is kept, clinical use is facilitated, and skin conditions can be observed in time for nursing.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The invention relates to the technical field of active peptides, and discloses a yolk-derived active peptide for promoting bone growth and a preparation method thereof. The preparation method comprises the following steps: cleaning, selecting, sterilizing and drying poultry eggs to obtain sterile poultry eggs; performing spray drying on yolk to obtain yolk powder, and performing degreasing treatment to obtain degreased yolk powder; sieving the degreased egg yolk powder, and adding deionized water to obtain a degreased egg yolk powder suspension; adjusting the pH and temperature of the degreased yolk powder suspension, and performing enzymolysis to obtain enzymatic hydrolysate; inactivating the enzymatic hydrolysate for later use; adding calcium lactate and zinc lactate into the enzymatic hydrolysate, adding geobacillus stearothermophilus, and fermenting to obtain fermentation liquor; separating to obtain an active peptide solution. According to the yolk-sourced active peptide for promoting bone growth and the preparation method, the active peptide with small molecular weight is obtained through distributed enzymolysis and fermentation and is easy to absorb, and calcium ions and zinc ions are added during fermentation, so that the active peptide is chelated with metal ions, and growth and bone development are promoted.

The present application relates to femoral stem prosthesis, specifically provides a femoral stem prosthesis with twisted trabecular structure, aims to solve the problem that although the existing femoral stem prosthesis has trabecular porous structure to promote bone growth, but still due to the high material elastic modulus and stress concentration inside the pore, leading to stress shielding effect and trabecular fracture, so it is difficult to effectively prevent long-term loosening of the prosthesis. For this purpose, a femoral stem prosthesis with twisted trabecular structure of the present application comprises a trabecular structure unit arranged on the surface layer of the prosthesis, the shape of the trabecular structure unit is a space net structure, the space net structure is provided with pores, the pores can accommodate new bone, and the space net structure is twisted from the inside of the prosthesis to the surface layer of the prosthesis. The present application introduces the mechanical regulation effect brought by structure twisting by arranging the space net trabecular structure which is twisted continuously from inside to outside on the surface layer of the prosthesis, on the basis of ensuring that the pores can be used for new bone growth and realizing bone-prosthesis biological fixation.

The invention discloses a food therapy height increasing method. The food therapy height increasing method comprises the following raw materials: enzymolysis bone calcium, oyster peptide, vitamin C, beta-carotene and hemin chloride. According to the present invention, the components such as the enzymolysis bone calcium, the oyster peptide, the vitamin C, the beta-carotene, the heme chloride and the like, which are beneficial to bone repair and bone growth and development, are extracted so as to meet the bone growth requirements of teenagers and children; the raw materials are processed and prepared into powder, all the components are prepared into the solid beverage in a mixing mode, and the solid beverage can be taken by adding sugar or honey or other flavors into water when being eaten. In conclusion, the solid beverage is suitable for teenagers and children to eat, different from a traditional food therapy mode, various growth promoting requirements are met, cooking is not needed, and the solid beverage can be taken after being mixed with water and is convenient to eat.

Title: Bone biostimulation device suitable for the oral cavity Bone biostimulation device (3) suitable for the oral cavity, comprising:- an arm (4) provided with a fixing interface, in particular an opening (13), capable of cooperating with a vibration generator (2) such as an electric toothbrush handle, and- a bone biostimulation head (5) fixed to one end of the arm, the head comprising a tip (6) made of flexible material intended to be pressed against a maxillary bone structure, in particular a bone crest (22), to transmit vibrations to the maxillary bone structure to stimulate bone growth. Figure to be published with the abstract: Figure 1

Disclosed are exemplary embodiments of materials for piezoelectric implants. Also disclosed are exemplary methods of poling materials for piezoelectric response for bone growth stimulation. Additional exemplary embodiments are disclosed of piezoelectric implants comprising such materials.

The application discloses a preparation method of egg yolk phospholipid polypeptide which is helpful for bone growth and improvement of brain health, and comprises the following steps: (1) raw material pretreatment to obtain a reaction substrate solution; (2) primary enzymolysis to prepare a primary enzymolysis solution; (3) secondary enzymolysis to prepare a secondary enzymolysis solution; (4) inactivation, the temperature of the secondary enzymolysis solution prepared in the step (3) is adjusted to 85-95 DEG C, and the enzyme is completely inactivated by keeping for 10-15 min; (5) fermentation; (6) post-treatment, the fermentation liquid after the fermentation is kept at 50-60 DEG C for 10-30 min, and then cooling, centrifugation, collection of supernatant, vacuum freeze drying or spray drying of the supernatant are carried out, so that the egg yolk phospholipid polypeptide powder is obtained. The natural compound rich in specific functional peptide segments and phospholipids is prepared through the two-step enzymolysis coupling fermentation process, can effectively promote the growth and development of the bone, significantly improve the learning, memory and cognitive ability, and can significantly promote the proliferation of osteoblasts.

A cervical fusion implant with serrations and radio opaque marking and a method thereof is disclosed The cervical fusion implant is optimized for enhanced spinal stabilization and integration. The cervical spine fusion implant is constructed from polyether ether ketone, known for its exceptional durability and biocompatibility. The implant is designed with a robust body encased in a protective capsule. The design ensures superior structural integrity and functional utility. The implant incorporates a self-stabilizing screw assembly featuring at least four lateral surfaces, each with slits to promote bone growth and integration. Additionally, the anterior surface is equipped with a screw hole for secure fixation using a titanium screw. This combination of features aims to improve spinal stabilization, promote effective fusion, and ensure long-term implant performance. Furthermore, the implants assist to maintain normal cervical curvature of the patient.

The invention discloses an application of a humanized DKK-1 monoclonal antibody in preparation of a medicine for treating osteoporosis. A light chain and a heavy chain of the humanized DKK-1 monoclonal antibody are shown as SEQ ID NO.1-2. The invention further discloses a preparation method of the humanized DKK-1 monoclonal antibody. Animal experiments prove that the humanized DKK-1 monoclonal antibody can remarkably improve the bone mineral density of lumbar vertebrae and tibia of an osteoporosis model mouse and can promote bone growth, and a new treatment scheme is provided for treating osteoporosis.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

The present invention relates to a 100% natural product consisting of a natural matrix exhibiting emerging properties, which product allows the correct bone metabolism to be reestablished by correcting the behavior of mesenchymal stem cells and reestablishing the correct balance between cell populations that allow bone growth or remodeling. As demonstrated by the inventors, the product of the invention itself is a natural matrix representing native natural wisdom that is only capable of allowing physiological endogenous interconnection with other entities that are self-assembled in nature, such as humans. By rebuilding the correct function of bone metabolism, the product achieves beneficial results within the system scale, improving systemic metabolism and inflammatory status. In fact, the invention allows for a normal form transition based on verification of deterministic characteristics to verification of probabilistic characteristics based on functional redundancy logic, which will provide industrially viable sources of innovations for manufacturers of 100% natural therapeutic or beneficial product areas.