2results about How to "Inhibit bone resorption" patented technology

This invention relates to the field of zinc alloy surface modification technology, and particularly to a corrosion-resistant medical zinc alloy, its preparation method, and its applications. The preparation method includes the following steps: weighing raw materials according to the chemical composition of the zinc alloy; cleaning the surface of the raw materials; smelting, refining, and casting to obtain an ingot; subjecting the ingot to equal-channel angular extrusion deformation to obtain an extruded zinc alloy; performing high-energy ion implantation on the zinc alloy to obtain a nitrogen-ion-implanted zinc alloy; and preparing a coating on the surface of the nitrogen-ion-implanted zinc alloy to obtain the final product. This invention achieves a high-adhesion, dense, and uniform deposition effect on the alloy surface through the synergistic control of "equal-channel angular extrusion + high-energy nitrogen ion implantation + biomimetic coating deposition," solving the problem of severe galvanic corrosion at localized sites in existing zinc alloys under corrosive environments. Simultaneously, the dense deposition layer helps inhibit rapid dissolution of the zinc alloy surface, significantly reducing the corrosion rate of the zinc alloy in corrosive environments.

This invention relates to the field of biomedical technology and provides a method for preparing uracil-modified gold nanoconjugated materials and their applications. The method includes the following steps: in the presence of a reducing agent, a uracil ligand solution is slowly added to a gold precursor solution for a controlled reduction reaction to form gold nanoconjugated materials with an average particle size ≤2 nm; a thiolated uracil derivative is added to the dispersion of the obtained gold nanoconjugated materials, and the pH of the reaction system is adjusted to alkaline, so that the thiolated uracil derivative is bound to the surface of the gold nanoconjugated materials through Au-S bonds, thereby obtaining uracil-modified gold nanoconjugated materials. This material possesses ultra-small size, pH-responsive surface, and selective uptake characteristics by pathogens, enabling it to efficiently penetrate periodontal biofilms and achieve efficient clearance and virulence blocking against periodontal pathogens by interfering with bacterial proton kinetic potential and inhibiting the secretion of virulence factors.