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52 results about "Biomimetic coating" patented technology

Deposition of calcium-phosphate (CaP) and calcium-phosphate with bone morphogenic protein (CaP+BMP) coatings on metallic and polymeric surfaces

The invention is a medical implantable device which is coated by the method according to the invention. The surface of the substrate used for the implantable device, in the raw condition, following a cleaning regime and physiochemical pretreatments, is coated using a biomimetic process in a supersaturated calcium phosphate solution (SCPS) to obtain the desired coating coverage and morphology maintaining a ratio of calcium to phosphorus pH, as well as solution temperature plays a major role in yielding precipitation of the proper phase of CaP so that composition, morphologies, crystal structures, and solubility characteristics are optimal for the deposition process. The biomimetic coating adds the attribute of osteoconductivity to the implant device. To maximize bone growth, the implant must also induce bone growth, or possess the attribute of osteoinductivity. This attribute is acquired by the use of therapeutic agents, i.e. bone morphogenic proteins (BMP), growth factors, stem cells, etc. The preparation of the SCPS solution is slightly altered so that during the immersion of the implant in the SCPS, the therapeutic agents are co-precipitated and bonded with the CaP directly on the underlying surface of the implant device. A final dipping process into a BMP solution provides an initial burst of cellular activity. For delivering stem and / or progenitor cell, after drying the dipped solution of BMP, the cells are cultured on the surface of the implant.
Owner:HERKOWITZ HARRY N

Implant surface biomimetic coating material for promoting sacralization and preparation method thereof

The invention discloses an implant surface biomimetic coating material for promoting the sacralization and a preparation method thereof. The coating material is a compound of calcium phosphate cooperatively doped with various trace elements and organic macromolecules. The preparation method comprises the following steps of: immersing an artificial implant pretreated by acid or alkali in simulated body fluid containing various trace element ions and organic macromolecules; carrying out chemical precipitation treatment between 35 DEG C and 150 DEG C to ensure that the surface of the implant is subjected to calcium phosphate salt core forming and growth; and forming a continuous coating of calcium phosphate salt cooperatively doped with various trace elements and the organic macromolecules. The surface of the coating has a nanoscale fine structure, and the effects of slowly degrading and releasing active ions of calcium, phosphorus and various trace elements and promoting the sacralization of implants for diseased intraosseous injuries, bone fracture internal fixation and tooth root internal fixation in the oral cavity. The coating material has the characteristics of simple preparation process, controllable coating thickness, trace element content, crystallinity and degradation rate, and the like.
Owner:ZHEJIANG UNIV

Preparation method of crosslinking adhesion bionic coating composed of epoxy-containing phosphorylcholine polymer and dopamine

The invention discloses a preparation method of a crosslinking adhesion bionic coating composed of an epoxy-containing phosphorylcholine polymer and dopamine. An epoxy-containing glycidyl methacrylate monomer and a methacryloyloxyethyl phosphorylcholine monomer containing a phosphorylcholine hydrophilic group are subjected to simple solution free radical polymerization to synthesize the epoxy-containing phosphorylcholine polymer, which is then dissolved in a polar solvent along with dopamine to form a coating for coating the surface of a material requiring modification. The coating is then air-dried and is subjected to heating treatment in a Tris-HCl water solution with pH being 8.5, so that amino groups in the dopamine and on the surface of the a chitosan film are reacted with epoxy groups in the phosphorylcholine polymer and meanwhile crosslinking adhesion of the dopamine is carried out. By means of anchoring through reaction of the epoxy groups in the phosphorylcholine polymer and the amino groups on the surface of the chitosan film and adhesion of the dopamine, the phosphorylcholine group is fixed on the surface of the surface of the chitosan film, thereby producing the crosslinking adhesion bionic coating that can imitate a cellular outer membrane.
Owner:XIAN UNIV OF SCI & TECH

Dentin surface bionic hydroxyapatite coating preparation method

The invention discloses a dentin surface bionic hydroxyapatite coating preparation method, which relates to a method for preparing a bionic hydroxyapatite coating having a certain shape and a certain structure on the surface of decayed and sensitive dentin by using an electrochemical process. The method comprises the following steps: pretreating a dentin sample; subjecting the dentin sample to deproteinization treatment; and placing the sample in electrolyte gel for electrolysis, wherein the electrolyte gel comprises calcium and phosphorus solution, pig ameloblastin and hydroxymethyl cellulose, the pH value of the electrolyte gel is between 5.5 and 7.4, the treatment temperature is 30 to 55 DEG C, the current density is 0.3 to 2MA / cm<2>, and the treatment time is 30 minutes to 1 hour. When the method is used, the bionic coating of which the thickness is about 2 to 20 mu m is prepared, and the coating has the same mechanical performance as nature enamel and can combine with substrate dentin tightly. The coating has higher hardness and higher wear resistance and can restore dentin caries in early period, fill dentinal tubules and relieve dentine hypersensitivity.
Owner:SICHUAN UNIV

Preparation of nano-coating micropore surface implant having regeneration activity and antibacterial property

The invention relates to the preparation of a nano-coating micropore surface implant having a regeneration activity and an antibacterial property. The preparation is characterized in that the implant is a dental implant taking pure titanium or titanium alloy as a matrix and an artificial joint medicinal hard tissue implant material; and the surface of a matrix material is subjected to micro-roughness treatment, improved biomimetic liquid treatment and nano silver grain coating technology treatment to form a nano biomimetic coating structure having the regeneration activity and the antibacterial property, wherein the nano silver grain is a metallic silver elementary substance which is attached to the surface of the implant and has the antibacterial property and a tissue repairing function, and has the grain diameter of 6 to 50nm; and a nano coating crystal grain formed on the surface of the implant through treatment and induction is a bone-like hydroxyapatite material rich in calcium and phosphor. The micro-nano biomimetic coating implant has a bone-promoting regeneration activity and a high affinity; compared with an un-coating material, the coating implant is improved in the bonding force with bones by several times so as to effectively avoid the phenomena of loosening and shedding and to be a novel medicinal implant material having both the antibacterial property and the regeneration activity.
Owner:杭州伟智生物医药科技有限公司

Preparation method of calcium-strontium/gelatin biomimetic coating modified artificial ligament

The invention discloses a preparation method of a calcium-strontium / gelatin biomimetic coating modified artificial ligament. The preparation method comprises the following steps: adding strontium salt and calcium salt into a gelatin solution, stirring so as to be fully dissolved, to obtain an evenly mixed solution; immersing a plasma-treated surface modified artificial ligament into the solution, adding phosphate, and stirring to form a mixed solution, irradiating under sunlight or simulated sunlight for 20-60 minutes, and sucking dry with filter paper; repeating the third step until the preset mineralizing circulation times are achieved, thus obtaining the calcium-strontium / gelatin biomimetic coating modified artificial ligament. According to the method, the biological mineralization mechanism of natural bone is simulated, an inorganic salt layer of apatite is deposited by taking natural high polymer or gelatin as a matrix or a template, a coating is compounded on the surface of the material, so that the artificial ligament carries nanoscale strontium substituted hydroxyapatite, so that the biocompatibility and osteoconduction of the material can be improved, and the material can meet the clinically medical requirements on the aspects of bioactivity and mechanical performance.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Oil adhesion-control antifouling self-cleaning fluoride-free coating and preparation method

The invention discloses an antifouling biomimetic coating with low adhesion of oil and fat and a preparation method of the antifouling biomimetic coating. Dolphin elastic skin is adopted as a basic research model of the coating, and the coating is obtained through crosslinking of polymer materials with a high elastic modulus and a low surface energy. Through control on the cross-linking density ofthe coating, change of low surface energy content and other parameter control, the adhesion resistance of the coating to various oil and low-surface-tension liquids is achieved. The coating has excellent oil adhesion resistance in both static and dynamic environments. The coating can be applied to multiple substrate surfaces, and can be applied to surfaces of various metals, ceramics, glass, various polymer materials and other materials, the adhesion between the coating and a substrate is high, and good transparency, flexibility, corrosion protection and other performance are achieved; and the coating is mainly applied to ventilation device blades, fume hood fan blade parts, smoke exhaust ventilator fan blade parts and other fan blade parts, and has a good application prospect and economic significance in reduction of surface oil stain and dust pollution, reduction of energy consumption, improvement of the work efficiency and reduction of energy consumption.
Owner:JILIN UNIV

Surface modification for coating

A modified medical device substrate surface designed to improve adhesion of biomimetic surfactants to the medical device surface, thus reducing the risk of thrombosis is described. The surface modification is accomplished through either an application of a tie layer of a hydrophobic material on the substrate surface intermediate the biomimetic coating or through incorporation of a hydrophobic dopant in the polymeric substrate prior to extrusion or molding. Either method creates a hydrophobically modified surface that enhances the biomimetic surfactant bonding strength.
Owner:WILSON GREATBATCH LTD

Process for preparing probe for monitoring water quality of bionic coating containing phospholipid polymers in real time

The invention discloses a process for preparing a probe for monitoring water quality of a bionic coating containing phospholipid polymers in real time. The process comprises the steps of synthesizing polyquaternium-51 (p-methyl benzaldehyde (PMB)), and then preparing the probe with a PMB antifouling coating for monitoring the water quality. By virtue of the technical scheme provided by the invention, the operation is simple, the cost is low, the organism adhesion of the probe for monitoring the water quality can be effectively inhibited, and the maintaining cost of the probe can be reduced for a water quality monitoring system.
Owner:SUZHOU COSMETIC MATERIALS

Method for preparing phosphorylcholine biomimetic coating by photocuring

The invention discloses a method for preparing phosphorylcholine biomimetic coating by photocuring. The method comprises the following steps: I, preparing a phosphorylcholine polymer containing hydroxyl; II, solving the phosphorylcholine polymer containing hydroxyl and a sensitizer together in a polar solvent and uniformly to obtain a coating solution; and III, coating the coating solution on the surface of a modified material, carrying out a curing reaction on the aired material under ultraviolet illumination, and washing to obtain the phosphorylcholine biomimetic coating on the surface of the to-be-modified material. According to the phosphorylcholine polymer containing hydroxyl synthesized by a vinyl monomer containing a phosphorylcholine group and a vinyl monomer containing hydroxyl by virtue of a polymerization method, the phosphorylcholine polymer containing hydroxyl and the sensitizer are mixed and coated on the surface of the to-be-modified material and the phosphorylcholine polymer can be well cured on the surface of the to-be-modified material under ultraviolet illumination, so that a novel path for obtaining a stable phosphorylcholine biomimetic coating is provided.
Owner:XIAN UNIV OF SCI & TECH

Preparation method of traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis

The invention relates to a preparation method of a traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis. The method comprises the steps of 1, preparing calcium-phosphorus crystal supports; 2, slowly releasing an osteogenesis coating; 3, slowly releasing an angiogenesis coating; 4, repeating functional particles for 2-5 cycles and conducting crystallization and freeze-drying for use, wherein the operation is carried out in a sterile environment, and the calcium-phosphorus supports in the desired size and shape are prepared according to different clinical needs. The method has the advantages that a low-temperature micro-nano-deposition technique is used for sequentially and circularly carrying traditional Chinese medicine monomer components including salvianolic acid B and notoginsenoside R1 to construct the composite biomimetic calcium-phosphorus support material capable of promoting osteogenesis and angiogenesis at the same time. According to the low-temperature micro-nano-deposition technology, a biomimetic coating is prepared, calcium-phosphorus micro-nano crystals are formed in a buffer system, and thecrystals can be condensed into the supports with certain strength at normal temperature.
Owner:HANGZHOU HUIBO SCI & TECH CO LTD

Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition

The invention relates to biomimetic peptide-containing compositions for use, in particular, for application and or deposition on a magnesium alloy, e.g., substrate, to at least partially coat a surface of the magnesium alloy. The invention also relates to the coated magnesium alloy which is particularly useful for tissue and bone repair and regeneration applications, such as, for constructing medical implant devices.
Owner:UNIVERSITY OF PITTSBURGH

Preparation method of anti-osteoporotic micro/nano biomimetic coating of bone implant

ActiveCN103341210ABionic effectSolve the problem of insufficient bond strengthVacuum evaporation coatingSputtering coatingAcid etchingHydrofluoric acid
The invention discloses a preparation method of an anti-osteoporotic and high-bonding-strength micro / nano biomimetic coating of a bone implant. The method comprises: (1) putting the implant into a hydrofluoric acid solution for acid etching; and (2) putting the implant after the acid etching as a matrix into a magnetron sputtering sample introduction chamber, putting anti-osteoporotic strontium salt used as a target material into a main sputtering chamber, vacuumizing the main sputtering chamber and the sample introduction chamber, pre-sputtering the matrix for 20 minutes in the sample introduction chamber, sending the implant matrix into the main sputtering chamber, sputtering for 2-4 hours, taking out the samples from the main sputtering chamber, and performing post-treatment in a heat treatment furnace, with a post-treatment temperature being 300-500 DEG C and an insulation time being 2-4 hours. The coating provided by the invention has characteristics of high adhesion strength with the matrix, osteoporosis resistance, micro / nano biomimetic structure.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Medium confinement type biomimetic catalytic membrane, and preparation method and application thereof

The invention discloses a medium confinement type biomimetic catalytic membrane. The membrane is composed of a substrate, a biomimetic material and medium confinement type mimetic enzyme MOFs particles, the biomimetic material is attached to the substrate to form a biomimetic coating, and the medium confinement type mimetic enzyme MOFs particles are attached to the biomimetic coating to form a medium confinement type mimetic enzyme MOFs particle layer. The medium confinement type biomimetic catalytic membrane has the beneficial effects that organic micro-pollutants can be rapidly removed by virtue of the strong oxidation capability of fixed medium free radicals and the adsorption capability of MOFs, and the medium confinement type biomimetic catalytic membrane has relatively good removal efficiency on aflatoxin, bisphenol A and diclofenac.
Owner:烟台中科恩吉科创新产业园管理有限公司 +1

Antibacterial fibroin-based bionic coating and preparation method thereof

The invention discloses an antibacterial fibroin-based bionic coating and a preparation method thereof. The bionic coating is prepared from the following raw materials: fibroin, caffeic acid dopamine, dopamine hydrochloride, chitosan fibers, polyurethane, boric acid, calcium metaphosphate, strontium fluorapatite, a seaweed extract, galuteolin, puffball powder, zinc oxide, strontium gluconate, glycine fumarate, potassium hydroxide, polyvinyl alcohol, distilled water, glycol salicylate and ethanol. The bionic coating provided by the invention is high in bonding intensity with a metal implant, low in coefficient of wear on a steel ball and excellent in wear resistance, and the bionic coating is excellent in antibacterial effect on staphylococcus aureus; and meanwhile, the bionic coating is good in biocompatibility, free from cell toxicity, free from formation of blood coagulation and thrombosis and free from any inflammatory reaction, and the bionic coating has a good clinical application value.
Owner:苏州纳贝通环境科技有限公司

Method of surface biocompatibility of modified material and biomimetic coating prepared from modified material

The invention belongs to the technical field of material surface science and polymeric biomedical materials, and particularly relates to a method of surface biocompatibility of a modified material anda biomimetic coating prepared from the modified material. The method comprises the following steps: ensuring that pentafluorophenyl methacrylic acid pentafluorophenyl ester monomer containing pentafluorobenzene groups and methacryloyloxyethyl phosphorylcholine containing phosphorylcholine hydrophile grouphydrophile group are subjected to simple solution radical polymerization reaction, so as to form phosphorylcholine polymer containing pentafluorobenzene groups, ensuring that the phosphorylcholine polymer and dopamine into a polar solvent, coating the phosphorylcholine polymer onto the surface of a modified chitosan membrane to ensure that the pentafluorobenzene groups are reacted with amidogen on the surface of the chitosan membrane and in dopamine, and fixing phosphorylcholine groups onto the surface of the chitosan membrane through polymerization adhesive attraction of dopamine and pentafluorobenzene group nucleophilic substitution grafting, so as to form the adhesive biomimetic coating with an imitation cellulosa membrane structure.
Owner:XIAN UNVERSITY OF ARTS & SCI

Antibacterial bionic coating as well as preparation method and application thereof

The invention belongs to the technical field of medical materials, and discloses an antibacterial bionic coating as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, activating the surface of a base material, then putting the activated base material into a neutral or slightly alkaline buffer solution, adding a polyphenol compound, zinc salt and the like to carry out a one-pot hydrothermal reaction, cleaning a product obtained by the reaction, then preparing a polyphenol / zinc-zwitter-ion coating through a hydrothermal method, and obtaining the antifouling and antibacterial bionic coating material with hydrophilicity. The preparation method is simple, reaction conditions are mild, and the prepared polyphenol / zinc-zwitter-ion coating material is good in safety, has the good antibacterial property, biocompatibility and the hydrophilic antifouling property and can be widely applied to the field of medical materials.
Owner:JINAN UNIVERSITY

Polymer bionic coating and preparation method thereof

The invention relates to the technical field of medical treatment, in particular to a polymer bionic coating and a preparation method thereof. The polymer bionic coating comprises a substrate, an inner layer and an outer layer, wherein the inner layer is attached to the substrate, and comprises a biocompatible polymer and an anti-inflammatory drug; and the outer layer is attached to the inner layer, and comprises an inflammation responsive polymer. Acute inflammation is caused in the process of implanting an implantable and interventional medical device modified by the polymer bionic coating into a blood vessel for intervening, the inflammation responsive polymer in the outer layer adsorbs excessive ROS, degradation occurs, and then the acute inflammation is eliminated. After the outer layer is degraded, the inner layer is exposed, and the anti-inflammatory drug contained in the inner layer is slowly released in a blood environment, so that the effect of resisting chronic inflammationis achieved, and the safety and the service time of the implantable and interventional medical device are improved. The polymer bionic coating disclosed by the invention has the capability of resisting platelet adhesion, has a relatively high BCI index and excellent anticoagulation capability, and can effectively inhibit inflammation and thrombus.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Preparation method of traditional Chinese medicine monomer sequence slow-release osteogenic angiogenesis calcium phosphorus scaffold material

The invention relates to a preparation method of a traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis. The method comprises the steps of 1, preparing calcium-phosphorus crystal supports; 2, slowly releasing an osteogenesis coating; 3, slowly releasing an angiogenesis coating; 4, repeating functional particles for 2-5 cycles and conducting crystallization and freeze-drying for use, wherein the operation is carried out in a sterile environment, and the calcium-phosphorus supports in the desired size and shape are prepared according to different clinical needs. The method has the advantages that a low-temperature micro-nano-deposition technique is used for sequentially and circularly carrying traditional Chinese medicine monomer components including salvianolic acid B and notoginsenoside R1 to construct the composite biomimetic calcium-phosphorus support material capable of promoting osteogenesis and angiogenesis at the same time. According to the low-temperature micro-nano-deposition technology, a biomimetic coating is prepared, calcium-phosphorus micro-nano crystals are formed in a buffer system, and thecrystals can be condensed into the supports with certain strength at normal temperature.
Owner:HANGZHOU HUIBO SCI & TECH CO LTD

Mechanical stability of the biomimetic coating by cross linking of surfactant polymer

A biomimetic surfactant polymer modified with various crosslinking embodiments is described. The crosslinking embodiments provide a biomimetic surfactant coating that is designed to resist cracking, scratching, spalling and chemical dissolution. The crosslinking embodiments comprise the use of various hydrophilic and hydrophobic functional groups. The modified biomimetic surfactant adheres to different substrate surfaces, particularly the surfaces of medical devices.
Owner:WILSON GREATBATCH LTD

A low energy consumption crop evapotranspiration water recycling system

The invention discloses a low-energy crop evapotranspiration water recycling system, which relates to the technical field of energy recycling, including a cultivation space in which crops are cultivated, and a circulation heat exchange module and a control module are arranged inside the cultivation space, and the circulation heat exchange The module includes a first air pump, a second air pump and a heat exchange tube. The head end of the heat exchange tube is provided with a moisture absorption growth chamber, and the end of the heat exchange tube is connected to the cultivation space. An atomizer is arranged on the moisture absorption growth chamber. The heat exchange tube includes a collector The water section, the water collection section is filled with a bionic water collection module, the surface of the bionic water collection module is provided with a bionic coating and contacts the inner wall of the water collection section, the water collection section is connected to a liquid storage tank, and the liquid storage pool is used to collect water in the water collection section For liquid water, a pumping operation module is arranged in the liquid storage tank, and the pumping operation module is used to put the liquid water collected in the liquid storage tank into the cultivation operation, and the control module includes an environmental monitoring module and a control module. The invention has the advantages of low cost, energy saving and high water collection efficiency.
Owner:INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI

Dentin surface bionic hydroxyapatite coating preparation method

The invention discloses a dentin surface bionic hydroxyapatite coating preparation method, which relates to a method for preparing a bionic hydroxyapatite coating having a certain shape and a certain structure on the surface of decayed and sensitive dentin by using an electrochemical process. The method comprises the following steps: pretreating a dentin sample; subjecting the dentin sample to deproteinization treatment; and placing the sample in electrolyte gel for electrolysis, wherein the electrolyte gel comprises calcium and phosphorus solution, pig ameloblastin and hydroxymethyl cellulose, the pH value of the electrolyte gel is between 5.5 and 7.4, the treatment temperature is 30 to 55 DEG C, the current density is 0.3 to 2MA / cm<2>, and the treatment time is 30 minutes to 1 hour. When the method is used, the bionic coating of which the thickness is about 2 to 20 mu m is prepared, and the coating has the same mechanical performance as nature enamel and can combine with substrate dentin tightly. The coating has higher hardness and higher wear resistance and can restore dentin caries in early period, fill dentinal tubules and relieve dentine hypersensitivity.
Owner:SICHUAN UNIV

A kind of anti-oil, anti-fouling, self-cleaning fluorine-free coating and preparation method thereof

The invention discloses an antifouling biomimetic coating with low adhesion of oil and fat and a preparation method of the antifouling biomimetic coating. Dolphin elastic skin is adopted as a basic research model of the coating, and the coating is obtained through crosslinking of polymer materials with a high elastic modulus and a low surface energy. Through control on the cross-linking density ofthe coating, change of low surface energy content and other parameter control, the adhesion resistance of the coating to various oil and low-surface-tension liquids is achieved. The coating has excellent oil adhesion resistance in both static and dynamic environments. The coating can be applied to multiple substrate surfaces, and can be applied to surfaces of various metals, ceramics, glass, various polymer materials and other materials, the adhesion between the coating and a substrate is high, and good transparency, flexibility, corrosion protection and other performance are achieved; and the coating is mainly applied to ventilation device blades, fume hood fan blade parts, smoke exhaust ventilator fan blade parts and other fan blade parts, and has a good application prospect and economic significance in reduction of surface oil stain and dust pollution, reduction of energy consumption, improvement of the work efficiency and reduction of energy consumption.
Owner:JILIN UNIV

A biomimetic coating of red blood cells for enrichment of circulating tumor cells

ActiveCN112011434BCapture firmer and more efficientAchieve capture purityCell dissociation methodsBioreactor/fermenter combinationsAntiendomysial antibodiesWhite blood cell
The invention discloses a red blood cell bionic coating for enriching circulating tumor cells. Through the dense arrangement of red blood cells on the substrate, non-specific adsorption of white blood cells on the substrate surface is avoided, and at the same time, folic acid (FA) or antibodies modified on the surface of red blood cells can directly target CTCs. The functionalized red blood cell bionic coating relies on its fluidity On the surface of the cell membrane, circulating tumor cells can be captured more firmly and efficiently, with a capture efficiency of more than 90%, and a CTCs capture purity of more than 80%. Red blood cells are derived from the same donor, avoiding the introduction of foreign matter, and high-purity CTCs can be isolated by using red blood cell lysate.
Owner:珞珈聚芯(珠海横琴)科技服务中心(有限合伙)

Preparation method of biomimetic coating containing epoxy phosphorylcholine polymer and dopamine cross-linked adhesion

The invention discloses a preparation method of a crosslinking adhesion bionic coating composed of an epoxy-containing phosphorylcholine polymer and dopamine. An epoxy-containing glycidyl methacrylate monomer and a methacryloyloxyethyl phosphorylcholine monomer containing a phosphorylcholine hydrophilic group are subjected to simple solution free radical polymerization to synthesize the epoxy-containing phosphorylcholine polymer, which is then dissolved in a polar solvent along with dopamine to form a coating for coating the surface of a material requiring modification. The coating is then air-dried and is subjected to heating treatment in a Tris-HCl water solution with pH being 8.5, so that amino groups in the dopamine and on the surface of the a chitosan film are reacted with epoxy groups in the phosphorylcholine polymer and meanwhile crosslinking adhesion of the dopamine is carried out. By means of anchoring through reaction of the epoxy groups in the phosphorylcholine polymer and the amino groups on the surface of the chitosan film and adhesion of the dopamine, the phosphorylcholine group is fixed on the surface of the surface of the chitosan film, thereby producing the crosslinking adhesion bionic coating that can imitate a cellular outer membrane.
Owner:XIAN UNIV OF SCI & TECH

Preparation method of artificial ligament modified by silver/silk protein/hydroxyapatite biomimetic coating

The invention discloses a preparation method of a silver / fibroin / hydroxyapatite biomimetic coating-modified artificial ligament. The method concretely comprises the following steps: 1, carrying out surface modification on an artificial ligament material, carrying out plasma processing, taking out and exposing the material to air, feeding the material into a grafting agent solution, cleaning the material with pure water and drying the material in vacuum, so as to obtain the surface-modified artificial ligament material; and 2, adding a soluble silver salt to a fibroin solution, adding a calcium source, stirring the solution to form a mixed solution, feeding the surface-modified artificial ligament material to the mixed solution, fully stirring the solution evenly, irradiating under sunlight or artificial visible light, sucking up by a filter paper, putting into a Na2HPO4 solution, standing still, then taking out and sucking up; and repeating the cycle. Compared with the prior art, the preparation method disclosed by the invention has the advantages of the biocompatibility and the osteoconduction property of the artificial ligament material can be improved, and the artificial ligament has antibacterial and anti-inflammatory properties, and can meet the requirements of clinical medicine on the aspects of biological activity and mechanical property.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Preparation method of two phosphorylcholine coatings containing catechol, amino groups and carboxyl groups

The invention discloses a preparation method of two phosphorylcholine coatings containing catechol, amino groups and carboxyl groups. The method comprises the following steps: carrying out a free radical polymerization reaction to obtain an amino-containing phosphorylcholine polymer and a carboxyl-containing phosphorylcholine polymer; then grafting 3,4-dihydroxy benzaldehyde to the amino-containing phosphorylcholine polymer, and carrying out reduction to prepare the phosphorylcholine polymer containing catechol and the amino groups; dissolving the carboxyl-containing phosphorylcholine polymerand the phosphorylcholine polymer containing catechol and the amino groups into a polar solvent to obtain a bionic coating; coating the surface of a material needing to be modified with the coating, and conducting airing, heat treatment and washing to realize surface modification of the material. The method is easy and convenient to operate, high in practicability and wide in application range, and the prepared bionic coating has good biocompatibility and stability. The method is suitable for the fields of blood purification, in-vivo implant materials, tissue engineering, sustained drug release, biosensors and the like.
Owner:XIAN UNIV OF SCI & TECH +1
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