52 results about "Biomimetic coating" patented technology

An additively manufactured medical implant, comprising a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone, and a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating.

The invention relates to a preparation method of a traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis. The method comprises the steps of 1, preparing calcium-phosphorus crystal supports; 2, slowly releasing an osteogenesis coating; 3, slowly releasing an angiogenesis coating; 4, repeating functional particles for 2-5 cycles and conducting crystallization and freeze-drying for use, wherein the operation is carried out in a sterile environment, and the calcium-phosphorus supports in the desired size and shape are prepared according to different clinical needs. The method has the advantages that a low-temperature micro-nano-deposition technique is used for sequentially and circularly carrying traditional Chinese medicine monomer components including salvianolic acid B and notoginsenoside R1 to construct the composite biomimetic calcium-phosphorus support material capable of promoting osteogenesis and angiogenesis at the same time. According to the low-temperature micro-nano-deposition technology, a biomimetic coating is prepared, calcium-phosphorus micro-nano crystals are formed in a buffer system, and thecrystals can be condensed into the supports with certain strength at normal temperature.

The invention discloses a method for preparing a strontium / fibroin bionic coating modified artificial ligament. The method comprises the following steps: 1, modifying a PET (polyethylene glycol terephthalate) artificial ligament; 2, immersing the pre-treated PET artificial ligament material in strontium-containing fibroin mixed liquor, stirring to react for 20-30 minutes, taking out and airing; putting the artificial ligament material into a fibroin solution, standing and airing; and 3, repeating the step 2 until the number of preset circulating times is achieved to obtain the strontium / fibroin bionic coating modified artificial ligament. According to the method, a biomimetic mineralization method is utilized, the fibroin is used as a mineralizing formwork, and strontium bionic fibroin composite coating modification is performed on the surface of the artificial ligament to form a composite coating with a uniform mineralized structure and stable performance, and the problem of poor tendon-bone healing of the artificial ligament in in-vivo application can be improved.

An apparatus for producing a biomimetic coating on an implantable article is provided. The apparatus includes an outer reactor for containing a biomimetic coating solution and an inner reactor arranged within the outer reactor. The inner reactor is smaller than the outer reactor so as to define a space between the inner and outer reactors. The apparatus also includes a pump system for circulating the biomimetic coating solution. The pump system is arranged to operate in the space between the inner and outer reactors. The inner reactor includes a flow control system that is selectively operable to control the flow of biomimetic coating solution between the outer and inner reactors.

The invention relates to a preparation method of a traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis. The method comprises the steps of 1, preparing calcium-phosphorus crystal supports; 2, slowly releasing an osteogenesis coating; 3, slowly releasing an angiogenesis coating; 4, repeating functional particles for 2-5 cycles and conducting crystallization and freeze-drying for use, wherein the operation is carried out in a sterile environment, and the calcium-phosphorus supports in the desired size and shape are prepared according to different clinical needs. The method has the advantages that a low-temperature micro-nano-deposition technique is used for sequentially and circularly carrying traditional Chinese medicine monomer components including salvianolic acid B and notoginsenoside R1 to construct the composite biomimetic calcium-phosphorus support material capable of promoting osteogenesis and angiogenesis at the same time. According to the low-temperature micro-nano-deposition technology, a biomimetic coating is prepared, calcium-phosphorus micro-nano crystals are formed in a buffer system, and thecrystals can be condensed into the supports with certain strength at normal temperature.

A biomimetic surfactant polymer modified with various crosslinking embodiments is described. The crosslinking embodiments provide a biomimetic surfactant coating that is designed to resist cracking, scratching, spalling and chemical dissolution. The crosslinking embodiments comprise the use of various hydrophilic and hydrophobic functional groups. The modified biomimetic surfactant adheres to different substrate surfaces, particularly the surfaces of medical devices.

The invention discloses a low-energy crop evapotranspiration water recycling system, which relates to the technical field of energy recycling, including a cultivation space in which crops are cultivated, and a circulation heat exchange module and a control module are arranged inside the cultivation space, and the circulation heat exchange The module includes a first air pump, a second air pump and a heat exchange tube. The head end of the heat exchange tube is provided with a moisture absorption growth chamber, and the end of the heat exchange tube is connected to the cultivation space. An atomizer is arranged on the moisture absorption growth chamber. The heat exchange tube includes a collector The water section, the water collection section is filled with a bionic water collection module, the surface of the bionic water collection module is provided with a bionic coating and contacts the inner wall of the water collection section, the water collection section is connected to a liquid storage tank, and the liquid storage pool is used to collect water in the water collection section For liquid water, a pumping operation module is arranged in the liquid storage tank, and the pumping operation module is used to put the liquid water collected in the liquid storage tank into the cultivation operation, and the control module includes an environmental monitoring module and a control module. The invention has the advantages of low cost, energy saving and high water collection efficiency.

The invention discloses a dentin surface bionic hydroxyapatite coating preparation method, which relates to a method for preparing a bionic hydroxyapatite coating having a certain shape and a certain structure on the surface of decayed and sensitive dentin by using an electrochemical process. The method comprises the following steps: pretreating a dentin sample; subjecting the dentin sample to deproteinization treatment; and placing the sample in electrolyte gel for electrolysis, wherein the electrolyte gel comprises calcium and phosphorus solution, pig ameloblastin and hydroxymethyl cellulose, the pH value of the electrolyte gel is between 5.5 and 7.4, the treatment temperature is 30 to 55 DEG C, the current density is 0.3 to 2MA / cm<2>, and the treatment time is 30 minutes to 1 hour. When the method is used, the bionic coating of which the thickness is about 2 to 20 mu m is prepared, and the coating has the same mechanical performance as nature enamel and can combine with substrate dentin tightly. The coating has higher hardness and higher wear resistance and can restore dentin caries in early period, fill dentinal tubules and relieve dentine hypersensitivity.

The invention discloses an antifouling biomimetic coating with low adhesion of oil and fat and a preparation method of the antifouling biomimetic coating. Dolphin elastic skin is adopted as a basic research model of the coating, and the coating is obtained through crosslinking of polymer materials with a high elastic modulus and a low surface energy. Through control on the cross-linking density ofthe coating, change of low surface energy content and other parameter control, the adhesion resistance of the coating to various oil and low-surface-tension liquids is achieved. The coating has excellent oil adhesion resistance in both static and dynamic environments. The coating can be applied to multiple substrate surfaces, and can be applied to surfaces of various metals, ceramics, glass, various polymer materials and other materials, the adhesion between the coating and a substrate is high, and good transparency, flexibility, corrosion protection and other performance are achieved; and the coating is mainly applied to ventilation device blades, fume hood fan blade parts, smoke exhaust ventilator fan blade parts and other fan blade parts, and has a good application prospect and economic significance in reduction of surface oil stain and dust pollution, reduction of energy consumption, improvement of the work efficiency and reduction of energy consumption.

The invention discloses a red blood cell bionic coating for enriching circulating tumor cells. Through the dense arrangement of red blood cells on the substrate, non-specific adsorption of white blood cells on the substrate surface is avoided, and at the same time, folic acid (FA) or antibodies modified on the surface of red blood cells can directly target CTCs. The functionalized red blood cell bionic coating relies on its fluidity On the surface of the cell membrane, circulating tumor cells can be captured more firmly and efficiently, with a capture efficiency of more than 90%, and a CTCs capture purity of more than 80%. Red blood cells are derived from the same donor, avoiding the introduction of foreign matter, and high-purity CTCs can be isolated by using red blood cell lysate.

The invention discloses a preparation method of a crosslinking adhesion bionic coating composed of an epoxy-containing phosphorylcholine polymer and dopamine. An epoxy-containing glycidyl methacrylate monomer and a methacryloyloxyethyl phosphorylcholine monomer containing a phosphorylcholine hydrophilic group are subjected to simple solution free radical polymerization to synthesize the epoxy-containing phosphorylcholine polymer, which is then dissolved in a polar solvent along with dopamine to form a coating for coating the surface of a material requiring modification. The coating is then air-dried and is subjected to heating treatment in a Tris-HCl water solution with pH being 8.5, so that amino groups in the dopamine and on the surface of the a chitosan film are reacted with epoxy groups in the phosphorylcholine polymer and meanwhile crosslinking adhesion of the dopamine is carried out. By means of anchoring through reaction of the epoxy groups in the phosphorylcholine polymer and the amino groups on the surface of the chitosan film and adhesion of the dopamine, the phosphorylcholine group is fixed on the surface of the surface of the chitosan film, thereby producing the crosslinking adhesion bionic coating that can imitate a cellular outer membrane.

The invention discloses a preparation method of a silver / fibroin / hydroxyapatite biomimetic coating-modified artificial ligament. The method concretely comprises the following steps: 1, carrying out surface modification on an artificial ligament material, carrying out plasma processing, taking out and exposing the material to air, feeding the material into a grafting agent solution, cleaning the material with pure water and drying the material in vacuum, so as to obtain the surface-modified artificial ligament material; and 2, adding a soluble silver salt to a fibroin solution, adding a calcium source, stirring the solution to form a mixed solution, feeding the surface-modified artificial ligament material to the mixed solution, fully stirring the solution evenly, irradiating under sunlight or artificial visible light, sucking up by a filter paper, putting into a Na2HPO4 solution, standing still, then taking out and sucking up; and repeating the cycle. Compared with the prior art, the preparation method disclosed by the invention has the advantages of the biocompatibility and the osteoconduction property of the artificial ligament material can be improved, and the artificial ligament has antibacterial and anti-inflammatory properties, and can meet the requirements of clinical medicine on the aspects of biological activity and mechanical property.