Preparation method of traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis

A scaffold material and angiogenesis technology, applied in the field of medical devices, can solve the problems of difficult healing, prolonged clinical action time, slow absorption, etc., and achieve the effects of promoting the formation of new blood vessels, promoting osteogenic mineralization and the formation of new bones

Active Publication Date: 2018-08-24
HANGZHOU HUIBO SCI & TECH CO LTD
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AI Technical Summary

Problems solved by technology

Salvianolic acid B (SALB), a monomer of traditional Chinese medicine, has good angiogenesis activity, and notoginseng saponin R1 (NGR1) has good osteogenic activity. The monomer components of traditional Chinese medicine are clear and the price is low, so clinical use can significantly reduce the cost of clinical treatment To reduce the economic burden of patients, the bone filling materials currently used in clinical practice mainly come from foreign countries, which are expensive and have unsatisfactory bone formation effects, slow absorption and difficult clinical healing, prolonging the clinical action time

Method used

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  • Preparation method of traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis
  • Preparation method of traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis
  • Preparation method of traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis

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preparation example Construction

[0035] The technical scheme adopted in the present invention is: the preparation method of the slow-release osteogenic angiogenesis calcium-phosphorus scaffold material of traditional Chinese medicine monomer sequence, the characteristic steps are as follows:

[0036] Calcium-phosphorus crystal scaffold preparation: the operation was carried out in a sterile ultra-clean bench. Take 40.1-42.5g sodium chloride (NaCL), 0.8-1.2g potassium chloride (KCL), 1.2-1.5g calcium chloride hydrate (CaCL 2 2H 2 O), 0.8-1.2g magnesium chloride hydrate (MgCl 2 6H 2 0), above-mentioned 4 parts of materials are dissolved in ultrapure water (MillQ water) simultaneously and stir, add the hydrogen chloride (1mM HCL) that 15-20 milliliter concentration is 1mM, pH drops to 1.8-2, and this is solution one. Get 0.3-0.4g disodium hydrogen phosphate hydrate (Na 2 HPO 4 2H 2O) Dissolve in 5 milliliters of ultrapure water (MillQ water), this is solution two, and pour solution two into solution one. ...

Embodiment 1

[0042] Calcium-phosphorus crystal scaffold preparation: the operation was carried out in a sterile ultra-clean bench. Take 42g sodium chloride (NaCL), 1g potassium chloride (KCL), 1.4g calcium chloride hydrate (CaCL 2 2H 2 O), 1g magnesium chloride hydrate (MgCl 2 6H 2 0), above-mentioned 4 parts of materials are simultaneously dissolved in ultrapure water (MillQ water) and stirred, and adding 18 milliliters of concentration is the hydrogen chloride (1mM HCL) of 1mM, and pH drops to 2, and this is solution one. Get 0.35g disodium hydrogen phosphate hydrate (Na 2 HPO 4 2H 2 O) Dissolve in 5 milliliters of ultrapure water (MillQ water), this is solution two, and pour solution two into solution one. Take 5g of sodium bicarbonate and slowly pour it into solution 1, and at the same time, add 1mM hydrogen chloride (1mM HCL) dropwise to monitor the pH value of the solution so that it is always kept at 6. Finally, ultrapure water was added so that the total amount of liquid was...

Embodiment 2

[0048] Calcium-phosphorus crystal scaffold preparation: the operation was carried out in a sterile ultra-clean bench. Take 40g sodium chloride (NaCL), 0.8g potassium chloride (KCL), 1.2g calcium chloride hydrate (CaCL 2 2H 2 O), 0.8g magnesium chloride hydrate (MgCl 2 6H 2 0), above-mentioned 4 parts of materials are dissolved in ultrapure water (MillQ water) simultaneously and stir, add the hydrogen chloride (1mM HCL) that 16 milliliters of concentrations are 1mM, pH drops to 1.8, and this is solution one. Take 0.3g disodium hydrogen phosphate hydrate (Na 2 HPO 4 2H 2 O) Dissolve in 5 milliliters of ultrapure water (MillQ water), this is solution two, and pour solution two into solution one. Take 4.5g of sodium bicarbonate and slowly pour it into solution 1, while adding 1mM hydrogen chloride (1mM HCL) dropwise to monitor the pH value of the solution to keep it at 5.8. Finally, ultrapure water was added so that the total amount of liquid was 1000 milliliters, and the r...

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Abstract

The invention relates to a preparation method of a traditional Chinese medicine monomer sequence slow-released calcium-phosphorus support material for osteogenesis and angiogenesis. The method comprises the steps of 1, preparing calcium-phosphorus crystal supports; 2, slowly releasing an osteogenesis coating; 3, slowly releasing an angiogenesis coating; 4, repeating functional particles for 2-5 cycles and conducting crystallization and freeze-drying for use, wherein the operation is carried out in a sterile environment, and the calcium-phosphorus supports in the desired size and shape are prepared according to different clinical needs. The method has the advantages that a low-temperature micro-nano-deposition technique is used for sequentially and circularly carrying traditional Chinese medicine monomer components including salvianolic acid B and notoginsenoside R1 to construct the composite biomimetic calcium-phosphorus support material capable of promoting osteogenesis and angiogenesis at the same time. According to the low-temperature micro-nano-deposition technology, a biomimetic coating is prepared, calcium-phosphorus micro-nano crystals are formed in a buffer system, and thecrystals can be condensed into the supports with certain strength at normal temperature.

Description

technical field [0001] The invention relates to a preparation method of a slow-release osteogenic calcium-phosphorus scaffold material for monomer sequences of traditional Chinese medicine, which can be made into a calcium-phosphorus scaffold material widely used in plastic surgery, trauma orthopedics and oral implant repair and reconstruction surgery, and belongs to medical equipment technology field. Background technique [0002] The repair of long-segment bone defects caused by trauma, tumor, inflammation, etc. is one of the most difficult problems faced by clinicians. It is difficult to repair long-segment bone defects, mainly due to the poor blood supply of bone defects, the difficulty of new blood vessel growth, and the inability to supply nutrients in time, which affects the osteogenesis effect. At present, the promotion of vascularized engineered bone is mainly combined with microsurgical techniques, but this method mainly provides blood supply for grafts through ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/28A61L27/50A61L27/54
CPCA61L27/12A61L27/28A61L27/50A61L27/54A61L2300/21A61L2300/216A61L2300/412A61L2300/604A61L2300/608A61L2420/02A61L2420/08A61L2430/02
Inventor 林振柳毅王晶杜江
Owner HANGZHOU HUIBO SCI & TECH CO LTD
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