19328results about How to "Improve effectiveness" patented technology

A method and apparatus for allowing the user of an electronic device to enhance privacy over a display with the use of software, are disclosed. A security window including a translucent graphical effects region may be displayed on the electronic device such that it overlays content the user may choose to protect. The security window allows the protected content to remain discernable for the user of the device yet substantially indiscernible to a person at a further distance and / or greater viewing angle from the screen of the device. One or more security windows, each of which may be of any size, shape, texture, translucency level and any other graphical or behavioral properties may be displayed on the display associated with the electronic device. The user may control the size, shape, texture, translucency level and any other graphical or behavioral properties of the security window and graphical effects region. The user may invoke or terminate a security window with the single click of a button. Security windows may automatically attach to applications in focus, or be attached in response to a user command, and allow uninterrupted usability of those applications.

The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.

The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and / or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and / or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

An electronic device with a display, a touch-sensitive surface, and one or more sensors to detect intensity of contacts with the touch-sensitive surface: detects, on the touch-sensitive surface, a gesture that includes an increase of intensity of a contact above a respective intensity threshold. In response to detecting the gesture: in accordance with a determination that the gesture includes a first number of contacts, the device generates a tactile output on the touch-sensitive surface; and in accordance with a determination that the gesture includes a second number of contacts different from the first number, the device forgoes generating the tactile output on the touch-sensitive surface.

A source computer 8 stores updated data that is to be distributed to a plurality of destination computers (12 to 30). The destination computers (12 to 30) are divided into groups sharing a common priority level (5, 4, 3, 2, 1). Each of these groups is then associated with a push update task to be executed by the source computer 8. These push update tasks are then sequentially executed. If a particular group of destination computers exceeds a threshold size, then it may be further divided in accordance with a hierarchy of splitting rules. The push update tasks use multicasting to transfer the update data to the destination computers within their groups in a manner that reduces network traffic.

The present invention provides compositions and methods for the delivery of interfering RNAs that silence APOB expression to liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

The present inventions provide an integrated, modular array of administrative and support services for electronic commerce and electronic rights and transaction management. These administrative and support services supply a secure foundation for conducting financial management, rights management, certificate authority, rules clearing, usage clearing, secure directory services, and other transaction related capabilities functioning over a vast electronic network such as the Internet and / or over organization internal Intranets.These administrative and support services can be adapted to the specific needs of electronic commerce value chains. Electronic commerce participants can use these administrative and support services to support their interests, and can shape and reuse these services in response to competitive business realities.A Distributed Commerce Utility having a secure, programmable, distributed architecture provides administrative and support services. The Distributed Commerce Utility makes optimally efficient use of commerce administration resources, and can scale in a practical fashion to accommodate the demands of electronic commerce growth.The Distributed Commerce Utility may comprise a number of Commerce Utility Systems. These Commerce Utility Systems provide a web of infrastructure support available to, and reusable by, the entire electronic community and / or many or all of its participants.Different support functions can be collected together in hierarchical and / or in networked relationships to suit various business models and / or other objectives. Modular support functions can combined in different arrays to form different Commerce Utility Systems for different design implementations and purposes. These Commerce Utility Systems can be distributed across a large number of electronic appliances with varying degrees of distribution.