269 results about "Drug concentration" patented technology

The invention discloses a method for in vitro slow release performance evaluation of a slow and controlled release preparation based on the overflow principle. A container with an upper outlet and a lower outlet is adopted to serve as a release tank, a to-be-detected medicine and a dissolution medium are placed in the release tank, a stirring device is adopted in the release tank to perform stirring, and the dissolution medium is added from the lower outlet of the release tank through a peristaltic pump; the dissolution medium dissolved with the medicine is taken away through the overflow from the upper outlet so as to offset medicine absorption or metabolism, and the slow and controlled release speed of the medicine, the total medicine overflow quantity and the total release amount are calculated by measuring the concentration of the medicine contained in the dissolution medium flowing out, the volume of the release tank and the overflow quantity. According to the method, the releasing degree of the slow and controlled release medicine can be evaluated accurately, the effective medicine release time of the slow and controlled release preparation is evaluated, and slow release performances of the slow and controlled release preparation are evaluated comprehensively.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses an administration agent in-vivo release and absorption visualization method based on a CFD-PBM coupling model. The method comprises the following steps: constructing a CFD model of a physiological environment of an injection site; establishing a population balance model (PBM) of the drug particles; the PBM is embedded into a CFD model solver, multi-scale coupling simulation is carried out, and a CFD-PBM coupling model is obtained; the three-dimensional visualization engine dynamically displays drug concentration distribution and particle behaviors; reversely adjusting preparation prescription parameters by using a multi-parameter optimization algorithm; and calibrating model parameters, and generating a key data report. According to the method, the prediction precision and the research and development efficiency can be remarkably improved, and the method is suitable for development of long-acting preparations such as microspheres and implants.

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The invention discloses a drug targeted delivery device and method, and belongs to the technical field of intelligent medical treatment. The device comprises the following modules: an intelligent targeted recognition module for accurately recognizing a gastric cancer specific molecular marker and improving the selectivity and specificity of targeted recognition in combination with a dynamic surface modification strategy; the microenvironment real-time monitoring module is used for monitoring key physiological parameters of the gastric cancer microenvironment in real time; the intelligent path planning module is used for dynamically calculating and optimizing a drug delivery path and realizing accurate drug positioning; the personalized drug administration regulation and control module is used for accurately predicting the drug dosage demand of an individual and dynamically and finely adjusting the drug administration amount in real time; the drug resistance risk management module is used for early warning a drug resistance risk in advance and automatically generating a personalized alternative drug administration strategy through multi-dimensional drug resistance analysis and real-time early warning; and the intelligent drug release module adopts a temperature-sensitive / pH-sensitive polymer shell layer and a nano valve to control drug release, so that precise gradient release of drug concentration is realized.

The invention provides an airway atomization flow intelligent drug delivery control method and system, and relates to the technical field of medical instruments.The method comprises the steps that basic information of the age, the weight and the illness state severity of a patient is obtained, and physiological parameters of the respiratory rate and the tidal volume of the patient are collected in real time through a sensor; inputting the basic information and the physiological parameters into a fuzzy adaptive control algorithm, and initializing an individual administration rule base according to the basic information; based on the real-time change trend of the respiratory rate and the tidal volume, three initial control index values including an atomization flow value, a drug concentration value and a time interval are dynamically generated through a membership function. According to the invention, through the full-process design of data acquisition, intelligent modeling, accurate execution and data closed loop, intelligentization of atomization treatment is realized.

The invention relates to the technical field of medical instruments, in particular to an inhalation device for monitoring drug concentration in real time and a dose regulation and control method.The inhalation device comprises a bottom plate and a dry powder storage tank installed on the bottom plate, a fixing block is installed at the top end of the dry powder storage tank, and an inhalation pipe connected into the dry powder storage tank is embedded into the fixing block; a gas storage tank is installed on one side of the top end of the bottom plate, a connecting pipeline is connected between the gas storage tank and the dry powder storage tank, a gas inlet pipe connected to the rear end of the suction pipe is embedded in the top end of the gas storage tank, and a gas pump is installed on the side, close to the fixing block, of the top end of the dry powder storage tank. The air guide pipe is connected to a flow dividing pipe at the inner end of the fixing block, a plurality of injection pipes extending to the inner pipe wall of the suction pipe are embedded in the flow dividing pipe, an air bag cavity is formed in the suction pipe, and a plurality of reinforcing ribs are fixedly connected to the inner end of the air bag cavity. The pipe diameter of the suction pipe is enlarged, and concentration is reduced.

The invention belongs to the technical field of medical materials and medicine, and discloses a microneedle patch for accelerating oral mucosa wound healing and a method and application thereof, and the specific preparation method comprises the following steps: (1) preparing a substrate material; (2) preparing a photoactive initiator; (3) loading HS-38 on methacrylated gelatin; and (4) manufacturing a microneedle to obtain the HS-38 loaded microneedle patch for accelerating oral mucosa wound healing. The preparation process of the microneedle patch does not need to depend on expensive instruments and equipment, operation is easy and convenient, and the microneedle patch has the advantages of being accurate in local delivery, noninvasive and painless, controllable in local drug concentration, stable in local drug concentration and the like. The strategy not only provides an effective means for treating chronic oral wounds, but also lays a foundation for realizing clinical transformation and application of medicines, and has wide popularization and application prospects.

The invention belongs to the field of antibiotic analysis and detection, and discloses a quinolone drug SERS (Surface Enhanced Raman Scattering) detection method based on an improved silver nano-substrate and a spectral angle matching model. An improved Lee-Meisel method is adopted to synthesize silver nano sol with precisely controlled particle size, molecular adsorption is realized by utilizing electrostatic interaction of a positively charged quinolone drug and negatively charged silver nano particles, and a high-density Raman enhanced hot spot is formed after an agglomeration agent is added; the SERS spectrum is collected at the excitation wavelength of 785 nm and the integral time of 10 s, qualitative distinguishing of drugs is achieved by combining a spectrum angle matching model, and quantitative detection is achieved by constructing a standard curve through the linear relation between the characteristic peak intensity and the drug concentration logarithm. The detection limit of the four drugs is as low as 1.03-1.16 ppb, the classification accuracy rate reaches 100%, the method is obviously superior to existing similar methods, the detection matrix range is wide, such as animal food and dairy products, and universality and high sensitivity are both considered.

The invention relates to the technical field of manufacturing of medical instruments, in particular to an intracranial controllable drug balloon dilatation catheter and a drug delivery method for a narrow area of a blood vessel. According to the intracranial controllable medicine balloon dilatation catheter, the inner-layer catheter body is arranged in the outer-layer catheter body in a sleeved mode and fixedly connected with the far end of the outer-layer catheter body; the balloon is assembled on the outer-layer tube body and is provided with a plurality of dosing holes along the circumferential direction; a medicine adhesion layer is compounded on the surface of the balloon section of the outer-layer tube body; the stress releasing pipe is connected to the end, close to the operation end, of the outer-layer pipe body. The Y-shaped tube base is connected to the end, away from the outer-layer tube body, of the stress releasing tube, one connector is connected with an injection device to inject medicine carriers into the balloon, and the other connector is used for a guide wire to penetrate through. When intracranial vascular stenosis is treated, directional drug release can be achieved by means of the drug delivery holes and the drug adhesion layer. The medicine is sprayed to the focus through the administration hole, the medicine is promoted to permeate into the middle layer of the blood vessel wall through the attaching force generated by the balloon expansion, the problems of non-uniform liquid medicine distribution, insufficient permeation and the like are effectively solved, and the local medicine concentration and the treatment effect are improved.

The application discloses a kind of intelligent optical genetic and microdosing spatiotemporal coordination measurement and control system based on catheter assembly, belong to biomedical engineering and automatic control cross technical field.The system obtains optical power spatial distribution model by intelligent optical genetic module, obtains drug concentration distribution model and carries out fluid back pressure monitoring and prevents blocking by microdosing module, then maximum coincidence space is calculated by spatiotemporal coordination optimization module and space relative coordinate deviation instruction is generated, finally, through catheter assembly execution module, instruction is responded to adaptively adjust the physical spacing of light guide and dosing channel.The advantage of the application is that the defects of light medicine dispersion field mislocation and microtubule easy blockage in the prior art can be effectively solved, and high-precision in-vivo light medicine collaborative intervention is realized.

This invention provides ozenafloxacin nanocrystalline particles, its preparation method, and its uses. The preparation method includes the following steps: dissolving ozenafloxacin raw material in an acidic aqueous solution, then adding a stabilizer, stirring, and adjusting the pH to 4-6; wherein the stabilizer is a siloxane and / or a cellulose derivative. The preparation method provided by this invention can obtain ozenafloxacin nanocrystalline particles with uniform and stable particle size distribution. Further research by the inventors has found that formulations containing these ozenafloxacin nanocrystalline particles can increase the amount of drug retained in the skin, thereby increasing the local drug concentration, achieving effective killing of Propionibacterium acnes, and preventing the development of drug resistance.

The invention provides a mesenchymal stem cell composition as well as a preparation method and application thereof in knee joint products, and belongs to the technical field of medicines. The invention relates to application of a mesenchymal stem cell combined naringin derivative in preparation of medicines for treating osteoporosis and repairing knee joint injury and arthritis. The naringin derivative is prepared from naringin through an ether esterification reaction, the metabolic cycle of the naringin derivative is prolonged and the water solubility is improved while the original activity is maintained, so that the free drug concentration and tissue infiltration capacity in bones are improved, the bioavailability of the naringin derivative is improved, and the bioavailability of the naringin derivative is improved. The prepared mesenchymal stem cell composition can induce mesenchymal stem cell osteogenic differentiation and improve bone repair capacity, has a good intervention effect on osteoporosis, has a sustained and controlled release effect and prolongs medicinal time.

The invention discloses a traditional Chinese medicine composition for treating hyperthyroidism and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating hyperthyroidism is prepared from cyclodextrin grafted modified hollow mesoporous organic silicon nanoparticles, traditional Chinese medicine ferment powder and a traditional Chinese medicine extracting solution, the cyclodextrin-grafted modified hollow mesoporous organic silicon nano-particles are used as a carrier, traditional Chinese medicine ferment powder and a traditional Chinese medicine extracting solution are loaded, the medicine concentration of a focus part is increased, traditional Chinese medicine ingredients are rapidly released through rapid response fracture of tetrasulfide bond functional groups, and the traditional Chinese medicine composition is prepared in an active targeting and fixed-point blasting mode. The bioavailability and the onset time of the medicine are improved, the leakage risk of the medicine is jointly reduced through the gating effect of cyclodextrin and responsive release of tetrasulfide bonds, synthesis of thyroid hormone is more thoroughly inhibited under the precise effect of high-concentration medicine and multi-target immunoregulation of traditional Chinese medicine, and the recurrence rate of hyperthyroidism is reduced.

Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and / or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and / or artificial pancreas (AP) algorithms, for example.

This medication management device comprises an acquisition unit, a storage unit, and a control unit. The acquisition unit acquires drug administration information including an administration amount and an administration time of a drug for a patient. The storage unit stores past drug administration information of the patient as drug administration history information. The control unit estimates an in-vivo drug concentration of the patient on the basis of the drug administration history information, and executes, on the basis of the estimated in-vivo drug concentration of the patient, a process determined from a plurality of different processes.

The patent document discloses a dosage form featuring a unique combination of extended-release and immediate-release components of the active ingredient. This dosage form allows for high drug loading, enabling once-daily administration while providing a sustained window of effective treatment with reduced fluctuations in drug concentration. The document also discloses a method for treating neurological or psychiatric diseases or conditions in a subject.

The invention relates to a riociguat prodrug as shown in a formula X or pharmaceutically acceptable salt thereof, a preparation method, an intermediate and a pharmaceutical composition thereof. The prodrug takes amino of riociguat as a modification site and is connected through an ester carrier, drug release is triggered by utilizing lung amidase, and lung targeted delivery is realized by adjusting a lipid-water partition coefficient. Pharmacokinetic studies show that the prodrug can significantly improve the drug concentration and total exposure of the lung, reduce the blood concentration of the whole body, and show excellent lung targeting characteristics. The invention also provides a pharmaceutical composition (preferably an inhalation preparation) containing the prodrug, and an application of the prodrug in preparation of drugs for preventing, treating, treating or relieving pulmonary arterial hypertension of patients. .

This invention discloses a method and system for evaluating the effectiveness of cardiac rehabilitation, relating to the field of medical and health technology. The method includes: acquiring physiological monitoring data, individualized parameter data, comorbidity data, multidrug therapy data, pharmacokinetic parameters, and pharmacodynamic interaction parameters of the target patient; generating baseline physiological index data without drug intervention based on the individualized parameter data and comorbidity data through a pre-set individualized cardiac response baseline model; calculating drug concentration based on multidrug therapy data and pharmacokinetic parameters; calculating comprehensive pharmacodynamic data by combining pharmacodynamic interaction parameters; generating predicted physiological data under multidrug intervention; subsequently obtaining purified physiological data through adaptive filtering and frequency domain decomposition; and finally generating a rehabilitation effect score through a pre-trained long short-term memory network model. Its beneficial effects include: distinguishing between drug interference and real cardiac function improvement, and improving the accuracy of rehabilitation assessment for patients undergoing multidrug therapy.

The application discloses a kind of deuterated benzamide diazepine compounds and preparation method and purposes thereof, and structure is as shown in general formula I.The compound is used as selective OX2R antagonist, and shows good activity, selectivity, brain exposure, brain blood ratio (the ratio of drug concentration in brain and drug concentration in blood, is called B / P), little toxic side effect, moderate half-life effect etc..It can be used for preventing, treating and / or reducing the disease related to orexin receptor.General formula I

The invention discloses an anti-tumor pharmaceutical composition with a synergistic effect and application thereof, the composition is composed of cis-platinum and atorvastatin, and the molar ratio of the cis-platinum to the atorvastatin is 1: 1.5; the invention provides a different drug concentration ratio scheme for treating cancer cells, inhibiting proliferation and activation of cancer cells and inducing apoptosis of the cancer cells by drug combination at low drug concentration, and compared with a traditional scheme, the scheme weakens drug resistance of the cells, and has the advantages of lower concentration, safer and more effective drug concentration ratio and higher safety. The toxic reaction of an organism caused by high-concentration drugs is weakened.

The invention discloses a colon-targeted pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention aims to solve the technical problems that the existing 5-aminosalicylic acid preparation is low in targeted delivery efficiency and lacks a synergistic interaction mechanism. According to the pharmaceutical composition, 5-aminosalicylic acid is used as a treatment component, and pH response type composite hydrogel constructed by sodium humate and sodium alginate is used as a carrier. The core characteristic of the pH-responsive controlled-release hydrogel is that sodium humate is a functional carrier component for forming a hydrogel network and realizing pH-responsive controlled release, and meanwhile, sodium humate is also used as an active component and has a synergistic interaction effect with 5-aminosalicylic acid. By means of the intelligent carrier, release of the medicine in the stomach is effectively inhibited, effective enrichment and continuous medicine release at the colon part are achieved, the local medicine concentration is remarkably improved, and an efficient and safe new strategy is provided for treatment of ulcerative colitis.

The application relates to the technical field of blood drug concentration detection, and discloses a blood drug concentration analysis method based on mass spectrometric detection, which comprises the following steps: adopting microfluidic technology in combination with solid-phase extraction to pretreat a blood sample to obtain a concentrated solution, so as to remove interfering components and concentrate target drug molecules; according to the physicochemical properties of the target drug molecules, the concentrated solution is selected to flow through a biosensor or is directly introduced into a chromatographic unit, and the target drug molecules in the liquid phase are converted into gas-phase ions when flowing through the biosensor; chromatography-mass spectrometry is adopted to detect the gas-phase ions or the concentrated solution, so as to obtain mass spectrum data; a machine learning model is used to analyze the spectrum data, to identify the drug types and calculate the concentration of the target drug molecules, and to generate an analysis report. The method is suitable for target drugs with different physicochemical properties, simplifies the detection process, and improves the applicability and accuracy of detection.

The invention discloses a dynamic diffusion cell for oral mucosa drug delivery and a method for simulating oral mucosa drug delivery. The dynamic diffusion cell comprises a sample cell, a receiving cell and a simulation membrane, and the bottom of the sample cell is communicated with the receiving cell through the simulation membrane; one horizontal side of the sample cell is connected with a sample cell inflow pipeline, and the other side is connected with a sample cell outflow pipeline; a receiving pool inflow pipeline is arranged on the upper portion of the side wall of the receiving pool, a receiving pool outflow pipeline is arranged at the bottom of the side wall, and the receiving pool inflow pipeline and the receiving pool outflow pipeline are communicated through a liquid storage bottle and form a circulation flow path with the receiving pool. By increasing the flow mechanism of the sample pool and the receiving pool, the amount of medicine lost due to salivary secretion of oral mucosa delivered medicine is effectively evaluated, the medicine concentration difference between the sample pool and the receiving pool is increased, the real proportion of medicine cross-mucosa absorption and swallowing loss is predicted, and the correlation between an in-vitro penetration test and the in-vivo actual penetration condition is improved.

The application relates to a corneal drug delivery scleral lens, which comprises a lens body, the lens body comprises a treatment area, a reverse area and a landing area from the center to the outside, the treatment area is located in the center, the reverse area is arranged around the treatment area and is used for connecting the treatment area and the landing area, the landing area is arranged around the reverse area and is used for supporting a scleral surface, so that a liquid accumulation layer is formed between a corneal front surface and the lens body; a flow guide pipe is arranged in the lens body in the radial direction, forming a liquid injection end and a drug delivery hole. The scleral lens of the application can supplement liquid medicine through the flow guide pipe without taking off the lens, dynamic fluid replacement is realized, and the cornea is prevented from being damaged by repeated taking off and wearing. When the lens is designed, the height of the reverse area is taken as a core variable parameterization design, the thickness of the liquid accumulation area and the drug concentration are accurately controlled. The overflow hole is normally sealed, and the risk of infection is reduced. The liquid medicine is diffused from the edge to the center, the whole surface of the cornea is uniformly soaked, and the bioavailability is improved.

The invention discloses a multi-system function regeneration factor composition as well as a preparation method and application thereof. The multi-system function regeneration factor composition is prepared from the following components in parts by mass: 0.8 to 2.4 parts of melatonin, 84 to 126 parts of nicotinamide ribose and 42 to 84 parts of resveratrol. According to the multi-system functional regeneration factor composition disclosed by the invention, through scientific proportioning and synergistic effect of melatonin, nicotinamide ribose and resveratrol, the functions of stem cells are strongly activated, proliferation of the stem cells is remarkably promoted, the stemness maintaining capability of the stem cells is improved, osteogenesis and adipogenesis differentiation potential is enhanced, and the regeneration effect of the stem cells is improved. Meanwhile, an NAD < + > metabolic pathway is activated so as to strengthen cell energy and anti-aging capability. The capsule adopts the design of combining quick-release pellets and sustained-release pellets, the quick-release part can quickly release melatonin, the local drug concentration can be increased in a short time, and stem cell activation signals can be quickly started; and the sustained release part slowly releases nicotinamide ribose and resveratrol to maintain the long-acting stability of the drug concentration, so that the effect taking speed is ensured, the action time is prolonged, and the bioavailability is greatly improved.

This invention relates to the field of traditional Chinese medicine (TCM) plaster technology, specifically to a method for preparing a highly permeable TCM plaster. The method includes the following steps: S1. Technology summary and model construction; S2. Disease analysis and technology selection; S3. Material selection and semi-finished product preparation; S4. Material mixing and addition; S5. Plaster classification and preparation; and S6. TCM patch preparation, verification, and preservation. This invention constructs a bidirectional gradient structure with particle size ranging from coarse to fine and drug concentration from low to high. This allows the drug to form a stable concentration difference from the drug storage layer to the skin surface during application, avoiding the problems of initial drug burst release and insufficient later release caused by the single particle size of traditional pastes. It also prevents the contact layer from rapidly losing water and forming a dense, hard shell due to excessive high-concentration drugs or fine powder, thereby significantly improving the cumulative transdermal rate within 24 hours and achieving long-acting, highly permeable transdermal drug delivery.

The invention belongs to the field of anti-tumor compounds, and particularly relates to a preparation method of carboplatin-unsaturated fatty acid liposome, which comprises the following steps: S1, preparing lecithin into a lecithin solution; preparing unsaturated fatty acid into a fatty acid solution; preparing carboplatin into a carboplatin solution; s2, adding a lecithin solution and a fatty acid solution into an eggplant-shaped bottle, then adding chloroform or dichloromethane, uniformly mixing, and carrying out rotary evaporation to obtain a phospholipid membrane; s3, taking and preheating a carboplatin solution, adding the carboplatin solution into the phospholipid membrane after preheating, and performing ultrasonic hydration to obtain a liposome solution; s4, performing ultrasonic crushing on the liposome solution; and S5, filtering the ultrasonically crushed liposome solution to obtain the liposome. The invention also discloses an application of the carboplatin-unsaturated fatty acid liposome prepared by the preparation method in preparation of antitumor drugs. The problem that in the prior art, the curative effect and safety of a carboplatin drug are difficult to consider at the same time can be solved, and metastatic tumor cells can be effectively inhibited at low drug concentration.

The invention discloses an application of a tumor-associated macrophage targeting nanoprobe in ultrasensitive magnetic resonance molecular imaging of in-vivo in-situ lung cancer. The tumor-associated macrophage targeting nanoprobe prepared by the method provided by the invention is loaded with water-insoluble supramolecular celopphane, so that Xe'molecular cage 'celopphane can be uniformly dispersed in water and a biological system, and is used for in-vivo hyperpolarized 129Xe magnetic resonance imaging. According to the nanoprobe, mannose modification is carried out on the surface of the nanoprobe, so that the nanoprobe can effectively target tumor-related macrophages in a tumor area, and targeted detection of in-situ lung cancer tumors is realized; the surface of the nanoprobe is subjected to near-infrared fluorescence molecular modification, so that fluorescence / magnetic resonance bimodal detection of solid tumors can be realized. In combination with the advantage that local drug concentration can be improved by pulmonary drug delivery, a strong 129Xe magnetic resonance signal of the developed probe can be directly detected in vivo, and in-vivo 129Xe magnetic resonance molecular imaging is realized on an in-situ lung cancer model mouse through a direct sampling imaging mode.

This utility model provides a concentration sampling device, relating to the field of drug concentration technology. It includes a workbench with a heater mounted on its upper surface. A steam box is mounted on the upper surface of the heater, and a condenser is mounted on the upper surface of the workbench. The steam box is connected to the condenser via a pipe. A drive assembly is provided on the upper surface of the workbench, and a box cover is mounted on the upper surface of the workbench via the drive assembly. A stirring and cleaning assembly is provided on the box cover. This utility model uses a servo motor to drive a rotating shaft, which in turn drives several stirring rods to rotate, stirring the drug inside the filter cartridge. This ensures sufficient contact between the drug and the liquid, guaranteeing the full combination of the liquid and the drug, and ensuring the quality of the liquid. Furthermore, the rotation of the rotating shaft drives a scraper to revolve, causing the scraper to rotate against the inner wall of the steam box, facilitating cleaning of the steam box and improving the convenience of the device.