The invention discloses a single-sample tumor
DNA copy number variation detection method and device. According to the method and the device, the
reference population benchmark level is simulated by utilizing the dynamic baseline fluctuation level, and the Z-
score value of the RC value of the
training set sample constructed by the clinical
tissue sample relative to the
reference population in each capture region is calculated based on the
reference population benchmark level fluctuation of each capture region; an SVR model of each
target capture area is trained by using the statistical
score; when single-sample tumor
DNA copy number variation detection is carried out, the SVR model of each region is used to calculate the
ratio value of the region, and finally, the region with
copy number variation is output according to
annotation and
filtering rules. According to the invention, the problem that the existing copy number variation detection method and
software cannot perform copy number variation detection under the condition of a
single sample is solved, and the defects of low sensitivity, low accuracy and the like caused by factors in the aspect of sequencing environment are overcome.