3 results about "Drug study" patented technology

The present application relates to the technical field of machine learning, and particularly relates to a preclinical drug experiment quality evaluation method based on machine learning, comprising: obtaining a plurality of experiment samples, each experiment sample comprising a dose level and an observation value of at least one biological index; determining a trend residual of each biological index of each experiment sample; determining a biological index evaluation weight sequence composed of quality evaluation weights of all biological indexes; determining a composite distance between any two experiment samples; determining a quality evaluation index of each experiment sample; and evaluating the quality of preclinical drug experiments based on the quality evaluation index of each experiment sample. By constructing a dose effect trend function, combining the trend residual and the weight, establishing a composite distance model fusing pharmacological trends, realizing adaptive selection of neighborhood parameters, improving the accuracy and stability of anomaly detection, overcoming the limitations of traditional machine learning LOF algorithm, and enhancing the evaluation reliability.

The invention discloses an application of betrixaban or a pharmaceutically acceptable salt thereof. Drug screening and in-vitro drug experiments find that betrixaban or pharmaceutically acceptable salts thereof can inhibit virus replication and infection ability, and can block virus-induced syncytial bodies, so that cell death caused by the syncytial bodies is reduced. In addition, the betrixaban or the pharmaceutically acceptable salt thereof provided by the invention has broad-spectrum antiviral activity, and also has the characteristics of safety and high efficiency.

The present invention relates to an immunodeficient non-human animal where endogenous drug metabolising enzymes and transcription factors are substantially inactivated. In some aspects of the invention, the animal expresses human drug metabolising enzymes and associated transcription factors. There is also provided related methods of generating the animal of the invention. Additionally, there is provided methods of performing preclinical drug studies using the animal of the invention.