1351 results about "Experimental animal" patented technology

The invention discloses a self-replicating RNA (Ribonucleic Acid) molecule, a porcine rotavirus RNA vaccine and application thereof, and relates to the technical field of vaccines. According to the present invention, the coding sequence of the porcine rotavirus G9P23 type VP4 protein is optimized, such that the fact that the saRNA prepared by using the nucleotide sequence represented by the SEQ ID NO: 10 can secrete the high porcine rotavirus G9P23 type VP4 protein antigen after the cell transfection is found; after the optimized porcine rotavirus G9P23 type VP4 protein is used for immunizing experimental animals, the level of neutralizing antibodies generated by the animals can be improved, and the challenge protection effect is enhanced. Therefore, the nucleic acid molecule provided by the invention can be used for developing drugs and vaccines for causing protective immune response in experimental animal bodies. Compared with a traditional vaccine, the vaccine provided by the invention has good immunogenicity and safety, and has a good application prospect.

The invention belongs to the technical field of blood detection, and particularly relates to an experimental animal blood detection device which comprises a detector body and a sample injection needle, and further comprises a sample mixing part, and the sample mixing part comprises a disc rotationally installed on the detector body; the fixing bases are installed on the disc, and clamping assemblies are rotationally installed on the fixing bases; the driving assembly is installed on the fixing base and comprises a main shaft rotationally installed on the fixing base and an auxiliary shaft used for driving the clamping jaw to rotate, a plurality of sets of auxiliary gears and main gears are installed on the auxiliary shaft and the main shaft respectively, the tooth ratios of the auxiliary gears and the main gears in each set are different, and the auxiliary shaft is of a telescopic structure; by arranging the driving assembly, different shaking speeds are adopted for blood collection tubes of different specifications, it is ensured that blood and an anticoagulant are evenly mixed, the situation of hemolysis or uneven mixing is avoided, and the detection accuracy and efficiency are improved.

The invention discloses a technology for targeted stimulation of a specific brain region and application of the technology in regulation and control of brain functions, and belongs to the field of animal cognitive behavior research. Techniques for targeted stimulation of specific brain regions include insulated stimulation electrodes that can generate AC voltage stimulation and a stimulation device for adjusting the AC voltage intensity and frequency. By applying the technology (ntTMS) for targeted stimulation of the specific brain region, an obvious magnetic stimulation effect can be achieved in the center of the brain region, cerebral neurons of a target region are activated, social and cognitive behaviors of animals are effectively regulated and controlled, and no obvious side effect is brought to experimental animals.

The invention relates to the technical field of extracranial strike testing, in particular to digitally-controlled extracranial strike construction equipment of a traumatic brain injury model. Comprising a test platform, a sliding rail installed on the test platform and arranged in the length direction of the test platform, an animal fixing platform slidably connected with the test platform through the sliding rail, an impact structure arranged on one side of the test platform and a driving structure used for driving the animal fixing platform to move towards the impact structure. The impact structure is fixedly connected to the test platform, the output end of the impact structure faces the animal fixing platform, an experimental animal is installed on the animal fixing platform, the driving structure drives the animal fixing platform to enable the experimental animal to actively impact, and the impact structure enables the experimental animal to impact a fixed acting point at a certain initial speed. The system is more in line with the injury mechanism of a patient with clinical actual craniocerebral trauma, and a tester can accurately control and monitor parameters according to the moving speed and the moving distance of the animal fixing platform.

The invention provides construction and application of a human pluripotent stem cell-derived heart organoid traditional Chinese medicine extract toxicity test chip. The chip comprises a plurality of micro-cell culture chambers and a micro-fluidic pore channel, heart organoid culture is carried out in the micro-cell culture room, culture media are added in the micro-fluidic channel to maintain the activity of the heart organoid, and traditional Chinese medicine extracts are added to evaluate the toxicity of traditional Chinese medicine. By simulating the reaction of the heart organ, the toxicity of the traditional Chinese medicine can be evaluated, the safety and effectiveness information about the traditional Chinese medicine can be provided, finally, the use of experimental animals can be reduced, and the animal welfare can be improved.

Automated system for handling, in particular for overturning, containers such as cage trays for housing laboratory animals. The automated system being suitable to be positioned at the outlet module of a station for treating or washing, the containers and possibly other component parts of the cages such as the lid, the trough and similar component parts. The system then receives the containers and / or other component parts at the outlet from the treatment station, in particular washing station. The system can comprise a first conveyor belt capable of interfacing the outlet module so as to receive the containers and / or the component parts at the outlet of the treatment station. A second conveyor belt can be arranged in succession so as to define a transport direction of the containers and / or component parts substantially parallel to the feed direction of the containers and / or component parts at the exit from the treatment station.

The invention provides a device and equipment for evaluating the dose-effect relationship of craniocerebral injury caused by human body explosive shock waves and a medium, and relates to the technical field of craniocerebral injury dose-effect relationship evaluation.The method comprises the steps that firstly, the scale law relationship of explosive shock wave attenuation coefficients of different species is established, and the incidence pressure peak values of the forehead of the human body corresponding to different incidence overpressure duration time are calculated; and then establishing a human body craniocerebral explosion injury 50% survival curve, and evaluating the craniocerebral injury dose-effect relationship of the person to be evaluated based on the curve. According to the evaluation device, by combining experimental animals with different weights and skull thicknesses, high-precision physical head models and other outfield actual explosion experiments, the dose-effect relationship of the craniocerebral injury of the experimental animals is transited to people, the dose-effect relationship of the craniocerebral injury of the human body is established, a craniocerebral injury evaluation system of the human body explosive shock waves is formed, and the complex structure of the craniocerebral of the human body is considered; and the dose-effect relationship of the animal is filtered into the human body, so that the dose-effect relationship of craniocerebral injury when the human body is subjected to explosion impact can be evaluated more accurately.

The invention discloses a method for researching the repairing effect of low-pressure and low-oxygen exercise on waist polyfidus injury, which comprises the following steps: S1, selecting and grouping experimental animals: selecting healthy adult rats, and randomly dividing the healthy adult rats into a plurality of experimental groups including a conventional exercise group, a low-pressure and low-oxygen exercise group, a low-pressure and low-oxygen treatment group and a control group; s2, setting a low-pressure and low-oxygen exercise environment: simulating a high-altitude environment by using a low-pressure oxygen cabin; the treadmill is used for rat running exercise; and S3, exercise plan implementation: performing exercise training on all the rats in the experimental group on the five-channel running machine. According to the invention, exercise training is carried out in a low-pressure and low-oxygen environment, so that a new physical intervention means is provided for rehabilitation treatment of waist muscle injury; researches show that movement under low-pressure and low-oxygen conditions is beneficial to acceleration of regeneration and repair processes of muscular tissues, which is crucial for rapid recovery of normal functions after acute or chronic waist injury.

The invention discloses a method for screening by combining a space transcriptome and CRISPR (clustered regularly interspaced short palindromic repeats) in a same unbiased mode and application of the method in gene function verification, and belongs to the technical field of biology. The method comprises the following steps: infecting target cells with CRISPR screening library viruses; sorting out positively infected target cells, and culturing for a period of time after knockout; injecting the target cells obtained in the previous step into an experimental animal body, wherein the experimental animal is an animal with autoimmunity deficiency; taking out tissues infiltrated by the target cells, and preparing frozen sections; transferring the frozen section to a spatial transcriptome slide, and loading on a machine to prepare a spatial transcriptome cDNA library; constructing a common transcriptome library and a CRISPR sgRNA library by using the space transcriptome cDNA library; and respectively carrying out sequencing and gene sequence comparison on the common transcriptome library and the CRISPR sgRNA library to obtain common transcriptome sequencing data carrying space coordinates and CRISPR sgRNA library sequencing data carrying space coordinates.

The utility model provides a protection device for an underwater animal experiment, and belongs to the field of underwater animal experiments. The brain cover part, the viscera cover part and the hip cover part are driven to be opened or closed through the opening and closing module, and the problem that in the prior art, an experimental device capable of protecting the brain and viscera of an experimental animal body from being damaged by vibration signals is lacked is solved. The device comprises a cover body module, a mounting base and an opening and closing module, the cover body module is fixedly mounted on the mounting base, and the opening and closing module controls the cover body module to be opened and closed; the cover body module comprises a brain cover part, an internal organ cover part, a hip cover part, a front side cover, a rear side cover, a bottom cover, a first partition plate and a second partition plate; the brain cover part, the viscera cover part, the hip cover part, the front side cover, the rear side cover, the bottom cover, the first partition plate and the second partition plate are each provided with an interlayer.

The invention discloses a humanized osteoporosis mouse model and a construction method thereof, and belongs to the technical field of biotechnology and animal models. The invention aims at the core defects of large species difference, insufficient humanization degree, low pathological simulation degree, unstable phenotype and the like of the existing osteoporosis model. The humanized osteoporosis mouse model is constructed through five core steps of experimental animal pretreatment, collagen-nano hydroxyapatite bionic scaffold preparation and cell pre-implantation, immune-bone metabolism double-derived system construction, progressive osteoporosis induction and model identification and verification. According to the method, double-person origination of immune and bone metabolism systems is realized for the first time, the colonization rate and survival time of human cells are greatly improved, the pathological process of clinical postmenopausal osteoporosis is accurately simulated, the phenotype of the model is stable and uniform, the reactivity matching degree with clinical drugs is high, and the method can be widely applied to research and development of anti-osteoporosis drugs and research of pathological mechanisms.

The invention relates to a second antibody for resisting mouse IgG and rabbit IgG as well as a preparation method and application of the second antibody. The second antibody of the anti-mouse IgG and the rabbit IgG sequentially comprises an anti-mouse IgG nano antibody, a biotin fixed-point binding peptide fragment and an anti-rabbit IgG nano antibody from an amino terminal to a carboxyl terminal. According to the design of the second antibody of the anti-mouse IgG and rabbit IgG with a brand-new structure and the preparation method, high-efficiency expression is realized, the second antibody of the anti-mouse IgG and rabbit IgG capable of realizing fixed-point biotinylation is obtained, the second antibody can be further subjected to various modification reformation based on a biotin-streptavidin bridge, the preparation method of the second antibody of the polymerase labeled anti-mouse IgG and rabbit IgG is further developed, and the application of the second antibody of the polymerase labeled anti-mouse IgG and rabbit IgG is expanded. According to the method, the polymerase-labeled mouse-rabbit universal secondary antibody with similar affinity to mouse IgG and rabbit IgG is obtained, the preparation period of the secondary antibody can be shortened, the preparation process of the secondary antibody is simplified, the stability between batches is improved, and meanwhile, the dependence on experimental animals is reduced.

The invention relates to a heptafluoropropane fire extinguishing system for an experimental animal barrier facility and a use method thereof, the heptafluoropropane fire extinguishing system comprises a plurality of smoke detectors arranged on a ceiling of the experimental animal barrier facility, and the smoke detectors are equidistantly arranged into a two-dimensional array formed by a plurality of square units; the plurality of heptafluoropropane nozzles are arranged in the centers of the square units, and an HEPA filter is mounted in each heptafluoropropane nozzle; each smoke detector is internally provided with at least one smoke collecting port facing the adjacent heptafluoropropane nozzle and a smoke sensor; the at least one heptafluoropropane gas cylinder is communicated with the heptafluoropropane spray head through conveying pipes, and each conveying pipe is provided with an electromagnetic valve; and the control unit is connected to the smoke sensor and the electromagnetic valves, and is configured to position a fire position according to a signal of the smoke sensor and control the corresponding electromagnetic valves to be opened, so that heptafluoropropane is sprayed through the adjacent heptafluoropropane spray heads to carry out local fire extinguishment.

The invention relates to the technical field of animal experiments, and particularly discloses an experimental animal PET-CT examination auxiliary fixing device which comprises a fixing base, the upper surface of the fixing base is fixedly connected with a first supporting column, the upper surface of the first supporting column is fixedly connected with a first limiting plate, and the side surface of the first limiting plate is fixedly connected with two supporting limiting blocks. The experimental animal PET-CT examination auxiliary fixing device is provided with a supporting limiting block and a positioning sliding rail, when the experimental animal PET-CT examination auxiliary fixing device works, by sliding a second supporting column, a transmission rolling wheel at the lower end of the second supporting column is used for supporting, friction force is dropped through rotation of the transmission rolling wheel, and therefore practicability is improved; and a second supporting column is conveniently guided, so that the movement stability of the second supporting column is improved, the distance between a first limiting plate and a second limiting plate is conveniently changed, and the convenience of fixing different rabbits is improved.

The invention discloses a drug screening method based on endotoxin attack, and relates to the technical field of drug screening, in the process of drug screening by using an experimental animal, firstly, an experimental animal model with diseases is established, a certain dose of endotoxin is given to the experimental animal for a period of time after the model is successfully built, and then the experimental animal is subjected to drug screening. And establishing evaluation indexes by utilizing a mathematical formula, and comprehensively evaluating the effectiveness and the safety of the medicine. The evaluation indexes comprise an endotoxin attack survival rate, a survival disease control rate and a survival disease control index. The method can be applied to screening of drugs for treating different diseases, and a more scientific and reliable screening method is provided for research of preclinical drugs or treatment methods.

The utility model discloses an experimental animal feed double-layer vacuum package automatic pushing device which comprises a first conveyor, a second conveyor, a lifting platform, a pushing assembly, a third conveyor, a grabbing assembly, a fourth conveying mechanism, a sealing mechanism and a fifth conveying mechanism which are sequentially arranged. Wherein two groups of the first conveyor, the second conveyor, the third conveyor, the fourth conveying mechanism, the sealing mechanism and the fifth conveying mechanism are arranged side by side. According to the double-layer vacuum shaping packaging machine, double-layer vacuum shaping packaging is met, automatic bag feeding, bag pushing and bagging and vacuumizing sealing of a second-layer packaging bag are achieved, the steps can be completed in one device, the occupied space is saved, and the packaging efficiency is improved; meanwhile, the double-layer packaging bag achieves independent vacuum packaging, double protection is achieved, contamination of microorganisms in product contents is avoided, a flat packaging form is formed, the risk probability of bumping and bag breaking is reduced, and the bag breaking protection effect is improved.

The invention relates to the technical field of non-human primate experimental animal upper limb movement ability evaluation and analysis, in particular to a non-human primate experimental animal upper limb movement ability comprehensive evaluation, data acquisition and analysis method. The comprehensive evaluation comprises the steps that upper limb comprehensive exercise ability evaluation is carried out by adopting an upper limb comprehensive exercise ability evaluation scale on the basis of upper limb feeding operation; and the upper limb coarse movement and the finger fine movement can be quantitatively evaluated. The data acquisition and analysis method comprises the following steps: S1, acquiring comprehensive movement time of upper limbs; s2, coordinate values of all key points of the upper limbs on a two-dimensional plane are obtained; s3, acquiring a 3D motion space trajectory; s4, analyzing the movement speed of the upper limb marked key points; s5, the joint angle of the elbow joint and the movement range of the palm, the elbow and the shoulder are obtained; and S6, analyzing to obtain finger key point distance change data. According to the invention, comprehensive objective evaluation and analysis of upper limb coarse movement and finger fine movement of non-human primate experimental animals can be realized.

The utility model provides a device for guaranteeing the uniformity of experimental animal feed powder, and relates to the field of experimental animal feed screening equipment, the device comprises a support, the top of the support is provided with a screening assembly, the screening assembly comprises a cylinder body, a screening cylinder, a wind wheel, a main shaft, a connecting rod and a stirring rod, the screening drum, the main shaft, the connecting rods and the stirring rods are all located in an inner cavity of the drum body, the screening assembly is used for screening smashed feed, and a conveying assembly is arranged on one side of the drum body; by arranging the screening assembly, the material conveying assembly and the transmission assembly, the effect of screening smashed feed is achieved, the transmission assembly is used for providing power for the screening assembly and the material conveying assembly, the material conveying assembly is used for continuously conveying the feed, and the screening assembly can disperse and screen the conveyed feed; and therefore, the crushed feed raw materials can be continuously screened, the uniformity of the crushed feed granularity is guaranteed, and other impurities are prevented from being mixed into the materials.

The invention discloses a method for constructing a renal injury animal model caused by combination of uric acid crystals and soluble uric acid, which comprises the following steps: applying a urate crystal suspension and a mixed solution of oteracil potassium and uric acid to an experimental animal, the dosage of the urate crystal suspension being 0.5-100mg / kg; the dosage of oteracil potassium per day in the mixed solution of oteracil potassium and uric acid is 750 mg / kg, the dosage of uric acid per day is 300 mg / kg, the dosage of oteracil potassium per day and the dosage of uric acid per day are both calculated according to the weight of the experimental animal, and the application time of the mixed solution of oteracil potassium and uric acid is 3-4 weeks. The invention also discloses the uric acid crystal and soluble uric acid combined renal injury animal model constructed by the method. The method can stably establish an animal kidney injury model caused by increase of soluble uric acid in the kidney and coexistence of urate crystals. And the established model is high in credibility, high in accuracy and universal.

The invention discloses an establishment method and application of a damp-heat intestine accumulation type ulcerative colitis animal model, and belongs to the field of animal models.The establishment method comprises the steps that S1, high-fat feed treatment is conducted, specifically, experimental animals freely eat high-fat feed for 6-10 weeks from the first day; s2, DSS treatment: feeding 1.5% (w / v) DSS solution to the experimental animal for 2 weeks; and S3, observing the damp-heat syndrome type and ulcerative colitis related indications of the experimental animals, and selecting the experimental animals meeting the scoring standard, thereby establishing the ulcerative colitis mouse model. Aiming at the situation that most patients induce ulcerative colitis due to excess energy due to the change of dietary structures and lifestyles at present, the invention constructs and evaluates the damp-heat accumulation type ulcerative colitis mouse model by inducing internal dampness by a direct pathogenesis (high fat diet), which is closer to the actual situation of clinical patients. Therefore, a model and reference are provided for research and treatment of pathology of the damp-heat accumulation type ulcerative colitis and pharmacological mechanisms of traditional Chinese medicines.

The invention belongs to the technical field of experimental zoology, and particularly relates to a gastric cancer precancerous lesion animal model and a construction method and application thereof. The construction method of the gastric precancerous lesion animal model comprises the following steps that a modeling animal freely drinks a modeling agent solution every day for modeling, and the concentration of the modeling agent solution is increased in a gradient mode within 200 mg / L-800 mg / L along with the modeling time. The gastric cancer precancerous lesion animal model is constructed by the method. The gastric precancerous lesion animal model is applied to screening, research and development of traditional Chinese medicines for treating gastric precancerous lesions including chronic atrophic gastritis, intestinal metaplasia and dysplasia. The method can solve the technical problem that the existing gastric precancerous lesion animal model construction method cannot accurately simulate the disease stage evolution, can simply, conveniently and efficiently construct the gastric precancerous lesion model, and has important meanings for scientific research verification, drug research and development, quality control, clinical application and the like of traditional Chinese medicines or formulae for treating gastric precancerous lesions.

The utility model relates to the field of experimental equipment, in particular to an experimental animal ear electrical stimulation fixing device which comprises a metal sheet and a clamp holder. The clamp holder comprises a first movable part and a second movable part, the first movable part and the second movable part are rotationally connected, and a tightening mechanism is arranged at the rotationally connected part; the first movable part and the second movable part are each provided with a clamping head and a handle. The metal sheet is fixedly located on one clamping head, and the metal sheet is opposite to the other clamping head. According to the scheme, the fixing effect of the metal sheet on the ear is improved, and the problem that the metal sheet is prone to falling off from the ear of an animal is solved.

The invention relates to the technical field of animal experiment devices, and discloses a spatial cognition enhancement device and method for three-dimensional rotational stimulation of a vestibular-hippocampus pathway, and the device comprises a rotational stimulation unit which is used for generating multi-axial angular acceleration stimulation; the animal adaptation unit is connected with the rotary stimulation unit and is used for fixing an experimental animal and blocking visual input; the control unit is in signal connection with the rotary stimulation unit and is used for adjusting stimulation parameters and collecting dynamic data; and the signal acquisition unit comprises a piezoresistive sensor and an analog-to-digital converter and is used for acquiring kinetic parameters of angular velocity and angular acceleration in real time. According to the space cognition enhancement device and method for three-dimensional rotation stimulation of the vestibular-hippocampus pathway, real three-dimensional space motion is simulated through multi-axial rotation, and targeted stimulation of the vestibular-hippocampus pathway is achieved in combination with adjustable rotating speed and visual shielding maintenance. The device is integrated with an acoustic intervention module and supports multi-mode intervention.

The invention discloses a construction method and application of a depression model. A drug capable of activating neurons in the lateral habenular nucleus brain area to discharge is given to the lateral habenular nucleus area of the brain of the experimental animal, and the depression model is obtained. The invention develops a new method for establishing the depression animal model by utilizing drug induction, local drug administration is performed on the brain of an experimental animal, abnormal discharge activity of neurons of lateral habenula nucleus (LHB) is activated, depression-like behaviors are generated, and the depression-like behaviors are induced to be more stable. Therefore, a new and reliable depression animal model is provided for researching the brain mechanism of depression and researching and developing novel drugs and non-drug intervention methods.

The transportable xenogenic organ transplantation donor animal experiment shelter comprises an outer cabin and an inner cabin, the outer cabin is a transport box, the inner cabin is arranged in the middle area in the outer cabin, and the areas on the two sides in the outer cabin are arranged as equipment rooms; the inner cabin is provided with a barrier area and a common area, a changing room, a feeding room and a dissecting room are arranged in the barrier area, and a preparation room, a first transfer cabinet, a feed room, a clean water room, a waste water collecting room, a second transfer cabinet and a decompression bin are arranged in the common area; a personnel circulation channel and an article and animal circulation channel are arranged in the inner cabin; the controller is arranged in the preparation room, and the controller is connected with the air conditioner, the waste gas treatment device and the generator set; living animals are transported to an organ transplantation site in the square cabin, experimental animals with organs to be removed can live in the square cabin, are in a standby state all the time, are removed after the operation of a patient is prepared, and are quickly implanted into the body of the patient, so that the problems existing in long-distance transportation of xenogenic organ transplantation at present are solved.

The invention belongs to the technical field of neurobiology and pain mechanism research, and discloses a full-automatic pain sense measuring system based on artificial intelligence integrated vital sign monitoring, which is integrated with multi-mode biological signal acquisition equipment, can synchronously record pain sense behaviors and physiological data (such as heart rate, respiratory rate, body temperature, excretion and the like) of experimental animals, and can be used for measuring the pain sense of the experimental animals. And the acquired data is analyzed and processed in real time by using an artificial intelligence algorithm to generate quantitative pain assessment indexes. Compared with a traditional pain assessment method depending on subjective observation, the system has the advantages that the efficiency and accuracy of data acquisition and analysis are remarkably improved, the human deviation can be reduced, and the assessment error rate is reduced to 5% or below. The method is particularly suitable for research of complex pain models and high-throughput drug screening, the preclinical research and development period can be remarkably shortened by 20%-30%, and the research and development cost is reduced. The invention has obvious market demand and economic benefit, and provides important technical support for the field of pain research.

The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.

The utility model relates to an experimental animal transfer device which is used for effectively reducing the stress reaction of experimental animals, does not need to be manually grabbed and avoids the injury risk of operators. Comprising a transition cage and a transfer cage, the transition cage is fixedly arranged between adjacent side wall structures of two group breeding cages, and the side wall structures of the group breeding cages are provided with transfer channels communicated with the internal space of the transition cage; first vertical sliding doors capable of shielding the transfer channels on the same side are respectively arranged on two sides of the transition cage, and a second vertical sliding door is arranged at the front end of the transition cage; third vertical sliding doors are respectively arranged at the front end and the rear end of the transfer cage; and a linking mechanism is arranged between the transition cage and the transfer cage.

The utility model relates to an ophthalmology instrument experiment animal platform which comprises an ophthalmology equipment adaptation frame and an animal platform body. The ophthalmology equipment adaptive frame comprises a column clamp, an adjusting frame and a base, the column clamp is used for clamping an ophthalmology equipment column, and the base is connected to the bottom of the adjusting frame and used for being supported on an ophthalmology equipment neck support; the animal platform is installed on the adjusting frame, the platform surface of the animal platform is located in the observation view field of the ophthalmology equipment in front of the adjusting frame, and an experimental animal fixing device is arranged on the animal platform; the experimental animal fixing device comprises an animal body fixing structure, a tooth fixing structure and a skull fixing structure to form a three-stage fixing system, so that the experimental animal is fixed and the eyes are still. The ophthalmological instrument experimental animal platform can be matched with common instruments for ophthalmological examination, experimental animals can be conveniently fixed, animal eyeballs are prevented from shaking and the like, the observation angle and distance of the eyeballs of the experimental animals can be accurately adjusted, the consistency of ophthalmological examination operation is guaranteed, and experimental animal imaging scientific research data are accurate.

The utility model relates to the technical field of animal feeding, in particular to an experimental animal water drinking device which comprises a box body, the box body is movably connected with a box cover, a first partition plate and a second partition plate which are perpendicular to each other are arranged in the box body, and the box body is divided into a heating area, a heat preservation area and a cooling area by the first partition plate and the second partition plate. An electric heating device is installed inside the heating area, a water inlet is formed in the top of the box cover above the heating area, a drinking water box is installed on the outer surface of the box body, and the top of the drinking water box is movably connected with a sealing cover. Hair or other dirt easily falls into the drinking water tray and pollutes the drinking water, the drinking water flows out of the drinking water box under the action of gravity by opening the recovery electromagnetic valve, replacement of the drinking water in the drinking water box is facilitated, and the situation that the drinking water is placed for a long time and easily breeds bacteria is prevented.