10 results about "Enrofloxacin" patented technology

This invention provides a composite aerogel based on Eucommia ulmoides gum and MXene nanosheets, its preparation method, and its application. The aerogel is prepared by reacting a toluene solution of Eucommia ulmoides gum with Ti3C2T... x MXene aqueous solution was mixed and a water-in-oil microemulsion was formed using a combination of ultrasound-assisted shaking. This allowed MXene nanosheets to self-assemble at the microemulsion droplet interface. Following vertical freezing and freeze-drying processes, a three-dimensional network structure of Eucommia ulmoides gum-Ti3C2T was successfully constructed. x MXene composite aerogel. The preparation method of this invention is mild and requires no chemical cross-linking agents. The resulting composite aerogel exhibits excellent adsorption performance for enrofloxacin, malachite green, Congo red, rhodamine, and kanamycin in water, with adsorption equilibrium times all within 10 minutes, enabling rapid removal of organic pollutants from water. This invention provides a new approach for the high-value utilization of Eucommia ulmoides gum and has promising application prospects in the field of water environment remediation.

A fermented traditional Chinese medicine feed additive for catfish, its preparation method, and its application are disclosed, relating to the field of aquatic feed additives. The preparation method involves activating and expanding the culture of *Saccharomyces cerevisiae*, *Bacillus subtilis*, and *Lactobacillus plantarum*; pulverizing *Paeonia suffruticosa* leaves, *Smilax china*, *Scutellaria baicalensis*, *Rhus chinensis*, hawthorn, *Polygonum cuspidatum*, ginkgo, and forsythia suspensa* to obtain traditional Chinese medicine powders; preparing a solid fermentation medium using the traditional Chinese medicine powders, soybean meal powder, corn cob granules, and wheat bran; inoculating *Saccharomyces cerevisiae* seed culture and *Bacillus subtilis* seed culture for aerobic fermentation; and inoculating *Lactobacillus plantarum* seed culture for anaerobic fermentation to obtain the fermented traditional Chinese medicine feed additive. The resulting fermented traditional Chinese medicine feed additive promotes the absorption and metabolic elimination of enrofloxacin in catfish, shortens the withdrawal period, has preventive and adjunctive therapeutic effects on bacterial diseases in catfish, promotes growth, reduces feed conversion ratio, and improves survival rate.

The application discloses a small-molecule multi-connection detection kit based on a biochip, a preparation method and a detection method thereof. The kit comprises nano-gold particle labeled antibodies, a multi-connection detection chip plate and a detection buffer. The nano-gold particle labeled antibodies comprise nano-gold particle labeled florfenicol antibodies and enrofloxacin antibodies. The multi-connection detection chip plate is coated with florfenicol antigens and enrofloxacin antigens in detection holes. The detection buffer is composed of 10-40 mM phosphate buffer and 0.05-0.5 wt% surfactant S17. The application can simultaneously detect florfenicol and enrofloxacin small molecules by using one detection buffer, thereby saving time and labor.

The application provides enrofloxacin suspension and a preparation method and application thereof, and is characterized in that, according to 100% by weight, the enrofloxacin suspension comprises the following components: enrofloxacin 4%-6%; sodium carboxymethyl cellulose 0.4%-0.6%; hydroxyphenyl ethyl ester 0.04%-0.06%; and purified water is supplemented to 100%. The drug particle size D90 in the enrofloxacin suspension is 2-10 microns. By limiting the weight ratio of each component and the synergistic effect between the formula, and by matching the drug particle size range of the suspension, the following comprehensive technical effects are achieved: long-acting slow release, low irritation, applicability to pregnant animals, multi-pathway drug delivery, low sedimentation rate, and almost no stratification.

The application relates to the chemical technology field, in particular to a compound of a ciprofloxacin intermediate, a preparation method and application thereof. The method comprises the following steps: carrying out N-cyclopropylization reaction on 3-chloro-4-fluorobromobenzene and cyclopropylamine in the presence of a composite catalyst to obtain N-cyclopropyl-3-chloro-4-fluoroaniline; and carrying out cyclization and hydrolysis on the N-cyclopropyl-3-chloro-4-fluoroaniline and EMME to obtain cyclopropyl carboxylic acid. The method has the advantages of easy raw material, simple process steps, avoidance of use of dangerous or expensive reagents, mild reaction conditions, suitability for industrial production, high purity of the intermediate compound prepared through the method, direct use of the intermediate compound for efficient synthesis of important quinolone antibacterial drugs such as ciprofloxacin and enrofloxacin, and important application value.

This application provides a *Staphylococcus pseudoci* AT8 strain for degrading antibiotics and its application. The *Staphylococcus pseudoci* is a species of Staphylococcus (…). Staphylococcus The *Staphylococcus pseudocarpa* species, having a 16S rDNA sequence as shown in SEQ ID NO:1, is named... Staphylococcus pseudoxylosus AT8, deposited on November 20, 2025 at the Guangdong Provincial Center for Microbial Culture Collection, accession number: GDMCC No: 67323. This application pertains to *Staphylococcus pseudocarpa*. Staphylococcus pseudoxylosus AT8 can achieve a degradation rate of over 90% for trimethoprim and tilmicosin, and over 78% for enrofloxacin. Furthermore, this application enriches the antibiotic-degrading bacterial strain library, promotes the control of new antibiotic pollutants in livestock and poultry manure and farmland soil, and facilitates the resource-based treatment and safe utilization of solid waste, demonstrating broad application prospects.

This invention belongs to the field of fluorescent carbon nanomaterial preparation and antibiotic detection technology, disclosing fluorescent carbon dots and their hydrogels and applications, as well as a method for detecting enrofloxacin. A fluorescent carbon dot hydrogel was constructed based on fluorescent carbon dots, and an enrofloxacin detection method was constructed based on fluorescent carbon dots or the fluorescent carbon dot hydrogel. The detection method involves mixing fluorescent carbon dots with the sample to be tested, according to... 411 / I 508 Enrofloxacin quantification is achieved by fitting the value of the G / B ratio to the enrofloxacin concentration; alternatively, the fluorescent carbon dot hydrogel is immersed in the sample and incubated for a sufficient time, and a colorimetric image is obtained under 365 nm ultraviolet light. The G / B value of the fluorescent carbon dot hydrogel region in the colorimetric image is obtained, and the quantitative analysis of enrofloxacin is achieved based on the fitting relationship between the G / B value and the enrofloxacin concentration. This invention can improve the accuracy of enrofloxacin detection and, furthermore, enable rapid and high-throughput detection of enrofloxacin.

This invention discloses a norfloxacin nucleic acid aptamer OUC-NOR7-2T and its application, belonging to the field of nucleic acid aptamer technology. The nucleotide sequence of the norfloxacin nucleic acid aptamer OUC-NOR7-2T is shown in SEQ ID NO.10. The application of the norfloxacin nucleic acid aptamer OUC-NOR7-2T in the identification or detection of norfloxacin is also discussed. The norfloxacin nucleic acid aptamer OUC-NOR7-2T of this invention was obtained through screening, exhibiting an affinity dissociation constant of 70.9 nM with norfloxacin. It shows no significant affinity for structural analogs of norfloxacin such as enrofloxacin, ciprofloxacin, ofloxacin, lomefloxacin, and pefloxacin, and can be used for the specific identification or detection of norfloxacin.

The application relates to a method for specifically recovering trace enrofloxacin antibiotics in aquaculture water bodies by using magnetic microsphere coupled antibodies, and relates to the technical field of water environment remediation. The method combines a biotinylated enrofloxacin monoclonal antibody with magnetic microspheres to obtain magnetic microsphere coupled antibodies, which are then added into water samples containing trace enrofloxacin for enrichment extraction, and then elution, and the supernatant is obtained by magnetic separation technology to obtain eluted enrofloxacin. The application constructs a magnetic immunoadsorption method by using the magnetic microsphere coupled antibody mode, and develops and optimizes the elution conditions, thereby realizing the specific recovery of trace enrofloxacin in aquaculture water bodies. The application is simple in operation, can specifically adsorb trace (a content of several mu g / L) enrofloxacin in water bodies, and the adsorption rate is as high as 97.68%, and the elution recovery rate is higher than 83%.