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Lomefloxacin hydrochloride (sold under the following brand names in English-speaking countries Maxaquin, Okacyn, Uniquin) is a fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.
Norfloxacin's nucleic acid aptamer OUC-NOR7-2T and its application
This invention discloses a norfloxacin nucleic acid aptamer OUC-NOR7-2T and its application, belonging to the field of nucleic acid aptamer technology. The nucleotide sequence of the norfloxacin nucleic acid aptamer OUC-NOR7-2T is shown in SEQ ID NO.10. The application of the norfloxacin nucleic acid aptamer OUC-NOR7-2T in the identification or detection of norfloxacin is also discussed. The norfloxacin nucleic acid aptamer OUC-NOR7-2T of this invention was obtained through screening, exhibiting an affinity dissociation constant of 70.9 nM with norfloxacin. It shows no significant affinity for structural analogs of norfloxacin such as enrofloxacin, ciprofloxacin, ofloxacin, lomefloxacin, and pefloxacin, and can be used for the specific identification or detection of norfloxacin.
Owner:OCEAN UNIV OF CHINA