11 results about "Ciprofloxacin" patented technology

The application discloses application of antibacterial peptide BMAP-28 and antibiotics in combined preparation of antibacterial drugs and belongs to the technical field of biological medicine. The antibiotics are selected from one or more of the following: ciprofloxacin, gentamicin and cefixime. The application combines the antibacterial peptide BMAP-28 with antibiotics such as ciprofloxacin and gentamicin, finds that the combination has a significant synergistic antibacterial effect on Enterobacter sakazii, can greatly save the dosage of the drug, reduce the toxic side effect and block the evolution process of drug resistance. Through the destruction of the bacterial cell membrane and the assistance of the antibiotic effect, the combination can effectively overcome the multiple drug resistance, widen the antibacterial spectrum and has a wide clinical application prospect.

The application discloses a complex preparation containing bovine lactoferrin and lyticase and application thereof, and belongs to the technical field of biology. The preparation is composed of bovine lactoferrin and streptococcal lyticase, and both are prepared through a baculovirus-insect cell eukaryotic expression system. Researches show that the complex preparation has a significant synergistic antibacterial effect. The complex preparation not only can effectively inhibit a plurality of gram-positive bacteria, but also can overcome the limitation that single streptococcal lyticase has weak activity on gram-negative bacteria, and significantly enhances the inhibiting effect on escherichia coli and salmonella. Especially, the complex preparation still has clear in-vitro antibacterial activity on multi-drug resistant escherichia coli such as ciprofloxacin and doxycycline, thereby providing a new way for developing a new type of drug for resisting drug-resistant bacteria.

The present application relates to a kind of porous biochar adsorbent based on polyphosphonic acid compound and alkali synergistic modification and its preparation method and application.The method includes: biomass powder is mixed with polyphosphonic acid compound solution and impregnated and dried, then is pyrolyzed first, obtains polyphosphonic acid modified biochar;Polyphosphonic acid modified biochar is mixed with alkali solution and impregnated and dried, then is pyrolyzed second, finally is pickled, washed with water and dried, and porous biochar adsorbent based on polyphosphonic acid compound and alkali synergistic modification is prepared.The porous biochar adsorbent obtained in the present application has ultra-high specific surface area and abundant micro-mesoporous hierarchical structure, surface is rich in phosphorus functional group (C-O-P and O-P), and for water body, ring ciprofloxacin, paracetamol and tetracycline and other drug and personal care product pollutants show excellent adsorption capacity and removal efficiency, suitable for pharmaceutical wastewater, medical sewage and trace new pollutants in surface water deep purification, with significant application prospect.

The application discloses a three-dimensional positive-negative general electrode, which is used for adsorbing organic pollutants and comprises a three-dimensional skeleton and an adsorption functional layer; the three-dimensional skeleton and / or the adsorption functional layer has conductivity; the adsorption functional layer is covered on the surface of the three-dimensional skeleton, and the constituent material of the adsorption functional layer comprises one or more of conductive polymers, biochar and synthetic carbon. The electrode has large adsorption capacity and high mass transfer efficiency, can efficiently capture organic pollutants in wastewater, and overcomes the problems of traditional physical adsorbents, such as easy loss and difficult recovery, and the like; when the electrode is used as a cathode or an anode to adjust and adsorb organic pollutants under the cooperation of an electric control, the electrode has stronger adsorption capacity and enrichment capacity. The application further provides a wastewater treatment system, which can quickly and completely treat wastewater, and provides applications of the three-dimensional positive-negative general electrode and the wastewater treatment system in treatment of organic pollutants, such as oxytetracycline, methylene blue, methyl orange and ciprofloxacin.

The application belongs to the technical field of photocatalytic materials, and particularly relates to a pyrene-based hydrogen bond organic framework composite photocatalyst as well as a preparation method and application thereof. The pyrene-based hydrogen bond organic framework is combined with hydroxylated nitrogen-doped titanium dioxide by electrostatic attraction, and a heterojunction composite material with selective adsorption-photocatalytic synergistic effect is constructed through structural modification, so as to solve the problems of weak adsorption capacity, low charge separation efficiency and poor degradation selectivity of traditional titanium dioxide. The generation and quenching balance of active oxygen are regulated through interface electron transfer, and the photocatalytic degradation efficiency of ciprofloxacin is significantly improved. The preparation process is mild and has good repeatability, the obtained material has excellent selective removal capacity and cyclic stability for ciprofloxacin and other antibiotics, can be used for efficient purification of refractory organic pollutants in water, and has good application prospect.

The application discloses a preparation method of sulfidation and nickel metal synergistically modified nano zero-valent iron for activating peracetic acid to degrade ciprofloxacin, and comprises the following steps: (1) preparing a mixed solution of NaBH4 and Na2S2O4: dissolving NaBH4 and Na2S2O4 in water to obtain a mixed solution of NaBH4 and Na2S2O4; (2) mixing a FeSO4.7H2O solution and a NiSO4.H2O solution, stirring under the condition of nitrogen, adding the mixed solution of NaBH4 and Na2S2O4 drop by drop after uniform stirring, continuously stirring to make the solution fully react after dropwise addition is completed, and washing and drying the obtained solid to obtain the sulfidation and nickel metal synergistically modified nano zero-valent iron. The sulfidation and nickel metal synergistically modified nano zero-valent iron prepared by the method has good peracetic acid activation efficiency in the process of activating peracetic acid to degrade ciprofloxacin, so that the complete removal of ciprofloxacin can be realized in a short time under the condition of low peracetic acid addition amount.

This invention relates to the field of wastewater treatment technology, and discloses a biochar-supported potassium ferric sulfide material and its application in pollutant removal. The material is prepared through the following steps: iron salt, sulfur source, and biomass are ground and thoroughly mixed in a specific ratio to obtain a first mixture; the first mixture is reacted under an inert gas atmosphere at a temperature range of 600-750°C for 1-3 hours, and then cooled to room temperature to obtain a second mixture; the second mixture is then washed and vacuum dried. The preparation steps of the material only include grinding and mixing, heating, washing, and drying, each step being relatively simple. The entire process involves only one pyrolysis, does not involve toxic gases, and is simple and safe to operate. Furthermore, experimental verification shows that the material has good effects on removing trichloroethylene, tetrachloroethylene, chlorobenzene, ciprofloxacin, and methylene blue from water.

The present application relates to the technical field of chemical application technology, in particular to a 5-KBC / Bi2WO6 / Zn0.05 composite photocatalyst and application thereof.The present application uses the invasive plant Spartina alterniflora as raw material, impregnates with KOH aqueous solution, and then carbonizes under high temperature in nitrogen atmosphere to prepare KOH-activated biochar material.The present application further combines the biochar material with Bi2WO6, effectively makes up for the deficiency of single Bi2WO6, and improves the photocatalytic performance of the material.On this basis, Zn 2+ is further introduced, a photocatalytic system with excellent performance is constructed, and efficient removal of the antibiotic ciprofloxacin in water is realized.This method not only provides a convenient and low-cost technical solution for the green and efficient treatment of antibiotic wastewater, but also opens up a new resource utilization approach for the treatment of invasive plants.

This invention provides a doped magnesium-iron layered double hydroxide (TLD) nanosheet array electro-Fenton material, its preparation method, and its application, relating to the field of water treatment catalytic materials technology. The doped magnesium-iron layered double hydroxide (TLD) nanosheet array electro-Fenton material comprises acetylene black and a doped magnesium-iron layered double hydroxide (TLD) nanosheet array supported on the surface of acetylene black. The doped magnesium-iron layered double hydroxide (TLD) nanosheet array includes the TLD nanosheet array and ferrous ions doped onto each nanosheet within the TLD nanosheets. The doped magnesium-iron layered double hydroxide (TLD) nanosheet array electro-Fenton material exhibits high catalytic activity, enabling in-situ generation and conversion of H2O2 in the electro-Fenton reaction, reducing H2O2 loss during diffusion, and improving H2O2 utilization and current utilization efficiency. The doped magnesium-iron layered double hydroxide (TLD) nanosheet array electro-Fenton material demonstrates good removal effects on various recalcitrant organic pollutants, such as bisphenol A, p-chloroaniline, ciprofloxacin, and chloramphenicol.

The present application relates to the technical field of pharmaceutical preparations, in particular to a powder aerosol intermediate composition and a preparation method thereof, a sodium ciprofloxacin inhalation powder aerosol and an application thereof. The raw and auxiliary materials of the intermediate composition include 1-7 wt% of sodium ciprofloxacin, 92-98 wt% of lactose and not more than 1% of magnesium stearate, in terms of mass percentage fraction; the D 50 of the sodium ciprofloxacin is 1-5 microns; the D 50 of the lactose is 100-150 microns. The intermediate composition can be used for preparing the sodium ciprofloxacin inhalation powder aerosol, and can realize efficient delivery of the sodium ciprofloxacin, improve the delivery efficiency of the sodium ciprofloxacin at a target site, and reduce systemic side effects. The sodium ciprofloxacin inhalation powder aerosol can be used for treating mild diseases such as cystic fibrosis, interstitial pneumonia and idiopathic pulmonary fibrosis, and thus expands the indications of the sodium ciprofloxacin.

This invention discloses alizarin / Al 3+ Application of alizarin / Al ratio fluorescent probe in ciprofloxacin detection 3+ The ratiometric fluorescent probe is composed of alizarin solution, AlCl3 solution, and HEPES buffer. In the presence of ciprofloxacin, upon excitation with light at a wavelength of 355-365 nm, it exhibits red fluorescence at 647-653 nm and blue fluorescence at 433-439 nm. Using red fluorescence as a reference signal and blue fluorescence as a response signal, the ratio of the two fluorescence signals shows a linear relationship with the concentration of ciprofloxacin, which can be used for the quantitative detection of ciprofloxacin. Furthermore, the alizarin / AlCl3 solution... 3+ The ratiometric fluorescent probe changes color from red through purple to blue as the concentration of ciprofloxacin increases, enabling semi-quantitative visual detection of ciprofloxacin. This alizarin / Al 3+ The base ratio fluorescent probe has excellent selectivity and anti-interference ability, which can realize the visual detection and quantitative analysis of ciprofloxacin residues in eggs with good sensitivity and high accuracy.