120 results about "Ciprofloxacin" patented technology

The invention discloses a method for degrading antibiotics in wastewater based on chitosan aerogel. The method comprises the following steps: adding chitosan aerogel Co-PBA / CS and potassium hydrogen peroxymonosulfate into the antibiotic-containing wastewater, and degrading under stirring. The method provided by the invention has a ciprofloxacin degradation capability of 94.7%. In addition, the material also has excellent self-cleaning and photo-thermal conversion performance, and can realize surface cleaning. The multifunctional aerogel provides a new strategy for removing pollutants such as ciprofloxacin in a complex and severe water environment.

The invention discloses a P.megaterium strain with stress resistance, growth promotion and environmental restoration functions and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M 2025912, and the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC NO: M 2025912; the Pristia megaterium XT106 provided by the invention is a strain capable of oxidizing manganese to form a biological manganese oxide, and the biological manganese oxide can adsorb and remove heavy metals (Cu, Sb, Pb, Zn, Cd and Cr) and degrade antibiotics (tetracycline and ciprofloxacin). The strain can move, tolerate acid-base, high-salt, phenanthrene and sulfamethoxazole environments, has the capability of generating a biological membrane, and can generate hydrogen sulfide, adsorb / fix and remove heavy metals (Cd, Pb, Zn, Sb and Cu) and promote plant growth.

The invention belongs to the technical field of preparation of functional environment-friendly materials, and discloses a preparation method of phosphoric acid modified cotton hull biochar for treating antibiotic wastewater. And carrying out high-temperature calcination in a nitrogen atmosphere to prepare the modified biochar material with rich pore structures and phosphorus-containing functional groups. The material has extremely high adsorption capacity to ciprofloxacin, the maximum adsorption capacity can reach 572.8 mg / g, and the material has a good removal effect and coexistence interference resistance to ciprofloxacin in actual wastewater. The adsorption mechanism mainly comprises electrostatic interaction, pi-pi interaction, hydrogen-bond interaction, surface complexation and the like. The material is simple in preparation process, low in cost, good in reproducibility and suitable for treatment of water bodies containing antibiotic pollutants such as pharmaceutical wastewater and aquaculture wastewater. The method fills the technical blank of high-value recycling of the cotton hull waste and cooperative treatment of antibiotic pollution, and has important environmental application prospects and industrial popularization values.

The invention relates to a preparation method and application of an alkali-activated iron tailing geopolymer adsorbent. According to the method, an iron tailing geopolymer is prepared through an alkali activation method, that is, an aluminosilicate structure in iron tailings is destroyed in an alkali activation mode, so that silica tetrahedron and alumina tetrahedron structures of the iron tailings are reconstructed, and a geopolymer material with adsorption capacity is prepared; on the basis, a foaming agent hydrogen peroxide solution is introduced to adjust the performance, and parameters such as modulus, water cement ratio and curing temperature of the alkali activator are respectively adjusted to prepare an optimal sample. The iron tailing geopolymer adsorbent material which is high in adsorption rate and good in stability is obtained, and the effect of adsorbing residual ciprofloxacin in wastewater is remarkable.

The invention relates to a preparation method of an alumina-loaded iron-aluminum co-doped graphene-like catalyst and application of the alumina-loaded iron-aluminum co-doped graphene-like catalyst in the field of water treatment. The method comprises the following steps: dispersing biomass (such as silkworm excrement, corncob and the like) in water to form a suspension, sequentially adding ferric salt, aluminum salt and a nitrogen source (such as urea, melamine and the like), adjusting the pH value, impregnating alumina pellets, drying, and roasting at high temperature in an inert atmosphere to prepare the immobilized catalyst. According to the catalyst, iron-aluminum co-complexed nitrogen-doped graphene is loaded on alumina pellets, and the catalyst has high specific surface area and active sites. The catalyst disclosed by the invention is suitable for degrading refractory organic pollutants (such as tetracycline, bisphenol A and ciprofloxacin) in water, can realize rapid degradation within 30 minutes through a synergistic effect with microorganisms, and is excellent in long-term operation stability (for example, the tetracycline removal rate is kept 100% for 106 days). The immobilized design of the catalyst facilitates separation and recovery, avoids secondary pollution, and is suitable for industrial water treatment. The matched curing bed reactor controls contact reaction of pollutants and a catalyst through a peristaltic pump, and continuous and efficient treatment is achieved. The method has the advantages of low raw material cost, simple process, high catalytic activity and cyclic utilization, and provides an efficient and environment-friendly solution for the treatment of organic polluted water.

The invention discloses a modified chitosan-based antibacterial material as well as a preparation method and application thereof, and belongs to the technical field of antibacterial materials. The ciprofloxacin grafted quaternized chitosan is successfully synthesized by taking the chitosan as a raw material, and the water solubility and the antibacterial ability of the chitosan are effectively improved. The antibacterial diameters of the ciprofloxacin grafted quaternized chitosan prepared by the preparation method disclosed by the invention on escherichia coli and staphylococcus aureus are respectively 35.34 to 39.06 mm and 40.45 to 44.51 mm, and the minimum MIC (Minimum Inhibitory Concentration) and MBC (Minimum Mass Chitosan) can reach 0.0005 mg / mL. In addition, the antibacterial material has an obvious inhibition effect on colletotrichum gloeosporioides and aspergillus niger, and the highest antifungal rates respectively reach 53.81 + / -2.17% and 54.88 + / -1.3%. Compared with the raw materials, the antibacterial ability is greatly improved, and the grafted and modified composite material is environment-friendly and can be used for antibacterial food packaging materials.

This invention discloses a method for preparing size-tunable porous Mn / Fe-based Prussian blue nanomaterials and their applications. This invention utilizes ion doping to prepare a series of uniformly tunable Prussian blue nanoporous materials by adjusting the ratio of Mn / Fe ions. The Prussian blue nanoporous materials prepared by this invention can activate H₂O₂ and rapidly degrade a 20 ppm ciprofloxacin solution within 20 min, exhibiting good cycling performance. This invention provides a simple one-step method for preparing size-tunable porous Mn / Fe-based Prussian blue nanomaterials, characterized by high economic efficiency and a simple preparation process, resulting in significant economic and environmental benefits.

An amorphous silica / cubic Co3O4 / cubic NiO / C nanocomposite material includes an amorphous Si phase, a cubic Co3O4 phase and a cubic NiO phase. Further, the amorphous silica / cubic Co3O4 / cubic NiO / C nanocomposite material has a granular morphology with an average grain size in a range from 0.5 to 2.5 μm, where the granular morphology includes nanoscale particles aggregated into the granular morphology. Still further, the nanoscale particles have an average particle diameter in a range from 30 to 90 nm. Furthermore, the amorphous silica / cubic Co3O4 / cubic NiO / C nanocomposite material has an adsorption capacity for ciprofloxacin of greater than or equal to 170 mg / g.

The application relates to the technical field of adsorbents, in particular to modified sodium alginate as well as a preparation method and application thereof; the preparation raw materials of the modified sodium alginate include sodium alginate, an activating agent, a mercapto reagent, a carboxylic acid compound containing an unsaturated double bond and an initiator. The application adopts natural polysaccharide sodium alginate as raw materials, which is widely sourced, non-toxic and biodegradable; a functional group carboxyl is introduced into the sodium alginate through a mercapto-alkene click reaction; the surface adsorption active sites of the modified sodium alginate are increased; the modified sodium alginate can effectively adsorb and remove methylene blue and ciprofloxacin in water; and the modified sodium alginate can still maintain good adsorption performance after being subjected to multiple cycles of adsorption-desorption.

The application discloses application of antibacterial peptide BMAP-28 and antibiotics in combined preparation of antibacterial drugs and belongs to the technical field of biological medicine. The antibiotics are selected from one or more of the following: ciprofloxacin, gentamicin and cefixime. The application combines the antibacterial peptide BMAP-28 with antibiotics such as ciprofloxacin and gentamicin, finds that the combination has a significant synergistic antibacterial effect on Enterobacter sakazii, can greatly save the dosage of the drug, reduce the toxic side effect and block the evolution process of drug resistance. Through the destruction of the bacterial cell membrane and the assistance of the antibiotic effect, the combination can effectively overcome the multiple drug resistance, widen the antibacterial spectrum and has a wide clinical application prospect.

The invention belongs to the field of degradation of antibiotics by photocatalytic materials, and particularly relates to a preparation method of a BiPO4 / Bi2WO6 baseball-shaped composite photocatalyst and application of the BiPO4 / Bi2WO6 baseball-shaped composite photocatalyst in the field of photocatalytic degradation of ciprofloxacin in a water body. In the invention, Bi (NO3) 3.5 H2O is used as a Bi source, and the BiPO4 photocatalyst is prepared by a solvothermal method; the Bi2WO6 photocatalyst is successfully prepared by utilizing a solvothermal method; the preparation method comprises the following steps: adding BiPO4 powder into Bi2WO6 turbid liquid, and enabling BiPO4 to grow on Bi2WO6 through an in-situ precipitation method to form the novel BiPO4 / Bi2WO6 composite photocatalyst. The two layers form a Z-type heterojunction, so that the recombination rate of electrons and holes is reduced, and the photocatalytic degradation effect is further enhanced. The BiPO4 / Bi2WO6 composite photocatalyst prepared by the method disclosed by the invention is simple, easy to obtain, economical and environment-friendly. Under the irradiation of simulated sunlight, a better light degradation effect is shown on ciprofloxacin wastewater, and after the ciprofloxacin wastewater is irradiated for 120 minutes, the degradation rate of the ciprofloxacin wastewater can reach 94.42%.

Neisseria gonorrhoeae is one of the most common bacterial sexually transmitted infections (STI). Diagnosis depends on standard nucleic acid amplification testing (NAAT), which is impracticable in most low-resource settings, where the prevalence of this STI is highest. Consequently, such areas utilize syndromic management, which misses a high proportion of cases and leads to antibiotic overuse, contributing to the troubling rise of resistance to the commonly prescribed ciprofloxacin, cefixime and ceftriaxone antibiotics for the treatment of N. gonorrhoeae infections. A specific, highly sensitive and cost-effective lateral flow assay is disclosed that utilizes CRISPR-Cas orthologs, multiplex SHERLOCK technology and isothermal amplification via recombinase polymerase amplification (RPA) for the rapid detection of antibiotic resistance to ciprofloxacin, cefixime and / or ceftriaxone at the point of care. This approach has the potential to increase treatment efficacy in the field and mitigate the spread of antibiotic resistance.

The application discloses a complex preparation containing bovine lactoferrin and lyticase and application thereof, and belongs to the technical field of biology. The preparation is composed of bovine lactoferrin and streptococcal lyticase, and both are prepared through a baculovirus-insect cell eukaryotic expression system. Researches show that the complex preparation has a significant synergistic antibacterial effect. The complex preparation not only can effectively inhibit a plurality of gram-positive bacteria, but also can overcome the limitation that single streptococcal lyticase has weak activity on gram-negative bacteria, and significantly enhances the inhibiting effect on escherichia coli and salmonella. Especially, the complex preparation still has clear in-vitro antibacterial activity on multi-drug resistant escherichia coli such as ciprofloxacin and doxycycline, thereby providing a new way for developing a new type of drug for resisting drug-resistant bacteria.

The invention belongs to the technical field of environmental functional material preparation and water pollution treatment, and particularly relates to a cyclodextrin-based metal organic framework porous aerogel material and a preparation method thereof. The method comprises the following steps: 1) modifying cyclodextrin by using a silane coupling agent to obtain silanized cyclodextrin marked as A-CD; 2) preparing a physical composite material marked as A-CD-MOF / PNC by using A-CD, a metal salt and a chlorine-containing organic cross-linking agent as raw materials through a co-crystallization method; and 3) under the action of a catalyst, carrying out chemical reaction on the A-CD-MOF / PNC and a chlorine-containing organic cross-linking agent to prepare a chemical composite material, namely the cyclodextrin-based metal organic framework porous aerogel material. The material has the inclusion effect of cyclodextrin molecules, the amino active sites of the amino silane coupling agent and the stable heterocyclic structure of PNC, and synergistic removal of ciprofloxacin and drug-resistant bacteria is achieved.

The invention belongs to the technical field of environmental material preparation, and particularly relates to a CuInS2 / Bi2O3 composite photocatalyst as well as a preparation method and application thereof. The CuInS2 / Bi2O3 composite photocatalyst disclosed by the invention comprises a CuInS2 nanosphere and a Bi2O3 nanosheet which is grown on the CuInS2 nanosphere, and a heterojunction is formed between the CuInS2 and the Bi2O3. Compared with a CuInS2 material, the CuInS2 / Bi2O3 composite photocatalyst has a better photocatalytic effect, can efficiently degrade ciprofloxacin-containing wastewater, is simple and convenient to operate, and is green and environment-friendly. Embodiments and application example data show that when the CuInS2 / Bi2O3-30 composite photocatalyst is used for photocatalytic degradation of ciprofloxacin, the ciprofloxacin degradation rate can reach 80% under the illumination condition, and excellent wastewater treatment efficiency is shown.

The invention belongs to the technical field of environmental protection, and provides a preparation method and application of phosphorus-doped two-dimensional transition metal carbide porous flexible aerogel. The method comprises the following steps: chemically etching a two-dimensional transition metal carbide precursor through a lithium fluoride-hydrochloric acid system, and carrying out ultrasonic stripping and centrifugal purification to obtain a single-layer nano material suspension; then, triphenylphosphine is adopted for phosphorus doping modification, and the electronic structure is optimized through high-temperature annealing treatment; the preparation method comprises the following steps: impregnating modified melamine sponge with polyvinyl alcohol (PVA) to construct a three-dimensional porous carrier, uniformly loading a phosphorus-doped two-dimensional carbide nano-material on the surface of the carrier, and finally preparing the flexible aerogel material with a hierarchical porous structure through a freeze-drying process. According to the scheme, by doping the phosphorus element, the conductivity of the two-dimensional transition metal carbide is effectively improved, multi-layer accumulation caused by interlayer Van der Waals interaction is reduced, and excellent catalytic activity is shown for removal of antibiotics in industrial wastewater; and compared with traditional persulfate (such as potassium hydrogen persulfate), ciprofloxacin (CIP) in industrial wastewater can be efficiently degraded, and a good treatment effect is achieved.

The application belongs to the technical field of biological medicine, and provides a ciprofloxacin derivative, a preparation method and application thereof. The ciprofloxacin derivative provided by the application has a structure shown in formula I, a positively charged electrostatic effect sequence (an amino acid part) is connected to a lipid part, then is conjugated with ciprofloxacin through a linker, and a series of amphipathic ciprofloxacin derivatives are formed. The positively charged electrostatic effect sequence can enhance the interaction with a negatively charged bacterial cell membrane through electrostatic action, then the lipid part can be inserted into a phospholipid bilayer of the bacterial cell membrane, leading to the integrity of the bacterial cell membrane being destroyed, the ciprofloxacin derivative entering the cell, and finally leading to the leakage of the bacterial cell content, the breakage of the bacterial chromosome and the death of the bacterial cell. The amphipathic ciprofloxacin derivative of the application simulates the amphipathic structure and membrane destruction mechanism of an antibacterial peptide, so that the ciprofloxacin derivative exhibits a unique advantage of not being prone to drug resistance.

The invention relates to the technical field of composite photocatalysts, in particular to a sulfur-rich carbon nitride homojunction photocatalyst as well as a preparation method and application thereof. According to the specific technical scheme, common carbon nitride and sulfur-rich carbon nitride are prepared through calcination, and common carbon nitride and sulfur-rich carbon nitride are mixed and then subjected to secondary calcination, so that efficient separation of photo-induced electrons and holes in the catalyst is achieved, the utilization rate of visible light can be increased, the photocatalytic efficiency of the catalyst is obviously improved, and the photocatalytic performance of the catalyst is improved. The preparation method has the advantages of simplicity, good repeatability, environmental friendliness and the like. The catalyst has a wide prospect in the technical field of sewage treatment, and is especially suitable for removing residual ciprofloxacin antibiotics in a water body through photocatalysis.

The present application relates to a kind of porous biochar adsorbent based on polyphosphonic acid compound and alkali synergistic modification and its preparation method and application.The method includes: biomass powder is mixed with polyphosphonic acid compound solution and impregnated and dried, then is pyrolyzed first, obtains polyphosphonic acid modified biochar;Polyphosphonic acid modified biochar is mixed with alkali solution and impregnated and dried, then is pyrolyzed second, finally is pickled, washed with water and dried, and porous biochar adsorbent based on polyphosphonic acid compound and alkali synergistic modification is prepared.The porous biochar adsorbent obtained in the present application has ultra-high specific surface area and abundant micro-mesoporous hierarchical structure, surface is rich in phosphorus functional group (C-O-P and O-P), and for water body, ring ciprofloxacin, paracetamol and tetracycline and other drug and personal care product pollutants show excellent adsorption capacity and removal efficiency, suitable for pharmaceutical wastewater, medical sewage and trace new pollutants in surface water deep purification, with significant application prospect.

The application provides a macrolide derivative and a preparation method and application thereof, relates to the technical field of medicinal chemistry, and the macrolide derivative is a compound with a general structure shown in the following formula I: in the formula, A is selected from any one of alkynyl, alkenyl or piperazine; R is selected from any one of H or F; X is selected from any one of CH or N, Y is selected from any one of methyl, ethyl or cyclopropyl, and n is an integer in the range of 2-6. The macrolide derivative is connected by different lengths of ether hydrocarbons at the 3-position, thereby avoiding the problem that the instability of a synthesized compound is caused by using an ester group as a side chain to connect a quinolone group. The application successfully prepares a macrolide derivative with double targets, and the antibacterial activity of the macrolide derivative is obviously better than the antibacterial activity of erythromycin, telithromycin, clarithromycin and ciprofloxacin which only have single targets.

The invention provides Kineococcus G2 and application of the Kineococcus G2 in preparation of a pigment with antioxidant activity, the Kineococcus new strain G2 is CCTCC No. M20242602, the strain is spherical, the size is 1.0 * 1.5 mu m, the optimal growth temperature is 30-37 DEG C, the pH value is 7.0-9.0, and the salt concentration is 1.0%-2.0%. The strain G2 is not sensitive to bacitracin, ciprofloxacin and norfloxacin, and is sensitive to novobiocin, polymyxin, gentamicin, piperacillin, ofloxacin, erythromycin, streptomycin, kanamycin, rifampicin, ampicillin, vancomycin, carbenicillin, chloramphenicol, tetracycline, penicillin, cefoperazone, oxacillin, amoxicillin and neomycin. Pigment generated by fermentation of the G2 strain has good antioxidant activity, and when the concentration is 10 micrograms / mL, the scavenging activity on DPPH is 25.00%, the scavenging activity on hydroxyl radicals is 80.58%, and the iron ion reducing capacity is 1.57, which are all higher than those of contrast beta-carotenoid. The application of the new Kineococcus strain G2 can lay a foundation for the research of antioxidant drugs such as medical treatment and health care product development.

The application discloses an iron-manganese complex graphene carbon catalyst supported on a zeolite, and a preparation and application thereof, and belongs to the technical field of water treatment. The catalyst is a GC@Mn-Fe3O4 / Zeolite catalyst, which is made of nitrogen-doped graphene carbon, Fe3O4, Mn3O4 and a zeolite, and a preparation method thereof is provided. The GC@Mn-Fe3O4 / Zeolite catalyst prepared in the application can drive the metabolism of microorganisms in water to antibiotics, and effectively removes three mixed antibiotics, i.e., ciprofloxacin, sulfamethoxazole and tetracycline, in water under the condition that no external energy is input, and the removal rate can reach more than 95%. In addition, the iron-manganese complex graphene carbon catalyst is supported on the zeolite, so that the stability of the catalyst is improved, and the catalyst has a good application prospect.

The invention provides an iron composite nitrogen-doped graphene-like catalyst as well as a preparation method and application thereof, and belongs to the technical field of water treatment catalyst preparation. The catalyst provided by the invention comprises an outer coating layer and an inner core to form a coated structure, the outer layer is a nitrogen-doped graphene-like material; the inner core is metal iron nanoparticles, and the size of the metal iron nanoparticles is smaller than 200 nm. The preparation method is simple and low in equipment requirement. The prepared NG-coated Fe catalyst can effectively and rapidly remove organic pollutants such as bisphenol, ciprofloxacin and atrazine in water under the condition that an oxidizing agent is not added, and the removal rate within 15 minutes is larger than 80%; the catalyst has a good removal effect on organic pollutants which are difficult to biodegrade under the neutral room temperature condition, and is good in stability and very low in dissolution rate of metal ions in the catalyst.

This invention discloses a highly efficient method for activating peroxymonosulfate (PMS) to degrade ciprofloxacin. The method employs a cobalt- and iron-containing degradation catalytic material to activate PMS and degrade ciprofloxacin. The key feature is the preparation of a multi-cavitary bimetallic carbon framework degradation catalytic material using a metal-organic framework derivatization method. This material is supported by a carbon skeleton and chemically bonded with cobalt and iron. The prepared bimetallic carbon framework degradation catalytic material and PMS are then added to the water containing ciprofloxacin to be degraded. The bimetallic carbon framework degradation catalytic material activates the PMS, thereby degrading ciprofloxacin. This invention reduces metal leaching, improves degradation stability, and increases the efficiency of PMS activation in degrading ciprofloxacin during the degradation process. It offers advantages such as simple material preparation, low cost, convenient implementation, good catalytic degradation effect, convenient recovery, and no secondary pollution.

The invention provides a staphylococcus aureus drug resistance prediction method based on whole genome association analysis and machine learning, and belongs to the technical field of bioinformatics and artificial intelligence crossing. Five common antibiotics such as erythromycin, ciprofloxacin, penicillin, fusidic acid and methicillin are selected as modeling objects. Performing comparison and SNP site detection on a strain genome by using a reference genome, and constructing a variation matrix; then, a pyseer tool is adopted for GWAS analysis, and genetic loci significantly related to the drug resistance of each antibiotic are screened as modeling features; and for each antibiotic, respectively constructing an independent machine learning model, inputting the SNP features screened by the GWAS, and outputting a drug resistance / sensitivity classification label. Through cross validation and independent test set evaluation, the model has excellent accuracy and F1 score on multiple antibiotics. According to the method, drug resistance prediction can be achieved based on genome data without traditional drug sensitivity experiments, and the method has the remarkable time advantage, popularization value and scientific research significance.

The invention provides a preparation method and application of a molecularly imprinted surface plasmon resonance (SPR) sensing chip of ciprofloxacin (CFX). According to the chip, molecularly imprinted polymers (MIPs) are combined with an SPR technology, so that the detection sensitivity and accuracy are effectively improved, the chip has obvious signal response to CFX with lower concentration, and the detection limit can be as low as nanomole level. When the CFX molecularly imprinted SPR chip prepared by the invention is used for CFX detection, the operation steps are simple, the analysis time is short, the specificity and reproducibility are good, the operation is simple and rapid, and the chip has important practical application value.

The invention belongs to the technical field of biosensors, and discloses a self-energized PEC aptamer sensor as well as a construction method and application thereof. According to the invention, the self-powered PEC biosensor for ciprofloxacin detection is constructed by integrating a CdS / PDA photo-anode and a CuInS2 photo-cathode. In the sensing system, the introduction of the photoanode is used for amplifying a photocurrent signal, and the photocathode is used for constructing a sensing interface. The ciprofloxacin aptamer is modified on the surface of the CuInS2 photocathode through chitosan and glutaraldehyde. When the ciprofloxacin exists, the ciprofloxacin can be specifically combined with the aptamer, electron transfer is hindered through a steric hindrance effect, and a photocurrent signal is reduced, so that sensitive detection of the ciprofloxacin is realized. The sensing platform shows relatively low detection limit and relatively good selectivity to ciprofloxacin, and a theoretical basis and an experimental basis are provided for constructing a novel and efficient self-energized PEC biosensor.

The application belongs to the field of wastewater treatment, and discloses a three-dimensional porous water treatment material synthesis method and application of purifying wastewater. The three-dimensional porous water treatment material is prepared by a hydrothermal synthesis method, and is hydrophobicity-regulated to form a multifunctional three-dimensional porous water treatment material. The surface of the three-dimensional porous water treatment material is rich in pore structures, and has the advantages of large adsorption capacity, improved adsorption performance on ciprofloxacin, and oil-water separation application. The three-dimensional porous water treatment material can remove antibiotics in wastewater and realize oil-water separation, and has the advantages of simple preparation process, excellent treatment effect, excellent adsorption performance, and wide application prospect.

A Co2O3—Bi2O3@SiO2 nanocomposite material includes Co2O3—Bi2O3@SiO2 nanocomposite particles having a granular morphology with an average diameter in a range from 10 to 30 nanometers (nm). The Co2O3—Bi2O3@SiO2 nanocomposite material has a Brunauer-Emmett-Teller (BET) surface area of greater than or equal to 70 square meters per gram (m2·g−1). The Co2O3—Bi2O3@SiO2 nanocomposite material has an adsorption capacity for ciproflaxin of greater than or equal to 70 milligrams per gram (mg·g−1).

The invention discloses a preparation method and application of an aromatic dicarboxylic acid-terbium complex fluorescent sensor array. The fluorescent sensor array comprises three fluorescent probes, the terbium complexes are respectively a 5-methoxy isophthalic acid-terbium complex, a 5-hexadecyloxy isophthalic acid-terbium complex and a 5-(6 '-cholesterol) hexyloxy isophthalic acid-terbium complex, and the preparation method comprises the following steps: (1) dissolving an aromatic dicarboxylic acid ligand in DMSO (dimethylsulfoxide) to obtain an aromatic dicarboxylic acid ligand mother solution; dissolving a terbium source in distilled water to obtain terbium ion mother liquor; and (2) adding the terbium ion mother liquor into an HEPES buffer solution, adding an aromatic dicarboxylic acid ligand mother liquor into the HEPES buffer solution, and carrying out constant-temperature reaction at 30-40 DEG C for 40-95 minutes to obtain the aromatic dicarboxylic acid-terbium complex. The fluorescent sensor array can be used for detecting tetracycline, cefixime, chloramphenicol and ciprofloxacin, and is high in accuracy and sensitive.