308 results about "Tetracycline" patented technology

The invention discloses a carbon quantum dot / metal organic framework composite material as well as a preparation method and application thereof, and the method is characterized in that carbon quantum dots derived from waterborne polyurethane are embedded into a zeolite imidazate framework 8 to prepare the carbon quantum dot / metal organic framework composite material. The composite material can be used as a ratio type fluorescent probe for trace detection of tetracycline, a dual-emission fluorescence signal of the probe is derived from tetracycline which quenches blue fluorescence of puCDs at 450 nm through an inner filter effect, and the coordination effect between Zn < 2 + > and tetracycline triggers an aggregation-induced emission effect, so that new fluorescence emission is generated, and the detection sensitivity is improved. The intensity of the two signals changes in proportion to the concentration of tetracycline, the wide linear concentration detection range and the low detection limit are achieved, the probe has the high recovery rate and the large adsorption capacity in detection, the problems that a traditional detection method is insufficient in sensitivity, poor in anti-interference capacity, high in cost and the like are solved, and the application prospect is wide. A new thought is provided for constructing a ratio type fluorescent probe with a removal function.

The invention discloses a tetracycline hydrochloride-containing wastewater treatment method in the field of wastewater treatment, which comprises the following steps: introducing tetracycline hydrochloride-containing wastewater into a reactor, adding a multilevel structure iron and iron sulfide composite carbon material, and adjusting the system to a nearly neutral condition; then adding potassium peroxymonosulfate composite salt, starting a direct current system, and carrying out catalytic degradation reaction under specific current density; and finally recovering the catalyst through magnetic field separation. The preparation method comprises the following steps: grinding pyrite and hematite, ball-milling and mixing the ground pyrite and hematite with orange peel powder and sodium hydroxide, and carrying out microwave pyrolysis, acid washing and drying, hydrogen peroxide surface treatment and the like to obtain a final product. According to the method, efficient degradation of tetracycline hydrochloride under the neutral condition is achieved, the catalyst can be magnetically recycled, secondary pollution is avoided, and the method has the advantages of being low in cost, easy and convenient to operate, environmentally friendly and the like.

The invention provides a fluorenyl alcohol derivative which can be used as an antibiotic adjuvant with a broad-spectrum synergistic effect. According to the compound, bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are taken as targets, and a series of fluorenyl alcohol derivatives targeting the bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are obtained through screening. The preferable compound WTU-15 can improve the antibacterial activity of antibiotics such as polymyxin, cefepime, tetracycline and the like on negative bacteria such as sensitive and drug-resistant escherichia coli, salmonella, klebsiella pneumoniae, acinetobacter baumannii and the like, and can also improve the in-vivo treatment effect of cefepime on mice infected by the drug-resistant acinetobacter baumannii. And the visceral organs of the mice survived after administration have fewer bacteria, and the mice are better after being healed. Normal physiological and visceral organ functions of the mouse are not affected by single and continuous administration of the WTU-15.

The invention provides a monatomic cobalt-based composite catalyst, a preparation method of the monatomic cobalt-based composite catalyst and application of the monatomic cobalt-based composite catalyst to degradation of antibiotics by activating peroxymonosulfate, and belongs to the technical field of advanced oxidation. The method comprises the following steps: mixing biomass powder and water to obtain a biochar suspension, adding cobalt nitrate hexahydrate into the biochar suspension, centrifuging the mixed solution, collecting residues, and drying to obtain a sample; and pyrolyzing the sample in a protective gas atmosphere, taking out, cooling, washing, and drying to obtain the monatomic cobalt-based composite catalyst. The cobalt-based catalyst prepared by the invention has high specific surface area, abundant pore structures and a large number of active sites, and is beneficial to activation of PMS and degradation of pollutants; the cobalt-based composite catalyst prepared by the method is used for activating peroxymonosulfate to degrade tetracycline, and the removal rate of tetracycline in a solution is greater than 99% after reaction is carried out for 20 minutes under a dark condition.

The invention relates to a carbon quantum dot-ZIF-8 compound capable of being used for sewage detection as well as a preparation method and application of the carbon quantum dot-ZIF-8 compound. Through cooperation of the ZIF-8 and the carbon quantum dots, the carbon quantum dot-ZIF-8 compound is allowed to realize high-precision detection of tetracyclines through a double-peak ratio method.

A system for the synthesis of a cost-effective photocatalyst based on the FeOOH / CuBi2O4 heterostructure, consisting of: a) a CuBi2O4 synthesis plant for the production of CuBi2O4 (CBO) microspheres from Bi(NO3)3·6H2O and Cu(NO3)2.3H2O precursors; b) a heterostructure formation unit is configured to deposit FeOOH nanoparticles onto an outer surface of the CBO microspheres to form an FeOOH / CBO heterostructure; and c) a processing unit configured to wash and dry the FeOOH / CBO heterostructure to obtain the photocatalyst.

The invention provides a preparation method and drug detection application of ZIF-8-Fe metal organic framework nano-enzyme, the ZIF-8-Fe metal organic framework nano-enzyme is prepared by adopting a heating reflux method, and peroxidase-like activity and drug detection application of the ZIF-8-Fe metal organic framework nano-enzyme are researched. In the presence of H2O2, the material can catalytically oxidize TMB to generate a blue product and shows good peroxidase activity, and through optimization experiments, proper reaction temperature and pH buffer system and optimal concentrations of ZIF-8-Fe, TMB and H2O2 are determined. Kinetic analysis shows that the affinity of TMB is superior to that of natural HRP, and a colorimetric detection method is established based on the inhibition effect of TC on the catalytic reaction. The method disclosed by the invention is reasonable in linear range, relatively low in detection limit and good in sample recovery rate and relative standard deviation performance, can be used for detecting tetracycline tablets, and shows a potential application value of the ZIF-8-Fe nano-enzyme in the field of drug detection.

The invention relates to the technical field of photocatalytic materials, in particular to a metal single atom loaded defect carbon nitride catalyst and a preparation method and application thereof. The method comprises the following steps: by taking melamine as a nitrogen source, soluble metal salt as a metal source and ethylenediaminetetraacetic acid as a chelating agent, carrying out freeze drying in a solvent system, calcining in a protective atmosphere, and carrying out thermal polymerization, so as to obtain the metal single atom loaded defective carbon nitride catalyst. The metal in the soluble metal salt is copper, iron or manganese. Precise anchoring and high dispersion of metal ions are achieved through complexing of ethylenediamine tetraacetic acid, a stable metal-N coordination structure is formed, metal agglomeration is avoided, a defect structure is constructed synchronously, and the metal monatomic loading capacity is 1 wt.%-7 wt.%. The catalyst can efficiently catalyze and activate peroxymonosulfate and rapidly degrade antibiotic pollutants such as tetracycline, has the advantages of being low in preparation cost, environmentally friendly, high in catalytic activity and high in stability, and is suitable for the field of water pollution remediation.

The invention belongs to the technical field of antibiotic pollutant degradation, and discloses a method for degrading antibiotic pollutants by using boron-carbon co-regulated nanoscale zero-valent iron as an activating agent, which comprises the following steps: step 1, synthesizing carbon-coated nanoscale zero-valent iron, marked as Fe0-C, through a hydrothermal method and a carbothermic method; and step 2, mixing the Fe < 0 >-C obtained in the step 1 with crystal boron, adding the mixture into sewage containing antibiotic pollutants, and then adding persulfate as an oxidizing agent to degrade the antibiotic pollutants. A boron-carbon co-regulation method is adopted to realize the passivation resistance of the nano zero-valent iron in the whole process from preparation, storage to application, and the nano zero-valent iron is applied to the process of activating persulfate to degrade tetracycline.

The present invention relates to nucleic acids and modified immune cells or precursors thereof, comprising a first polynucleotide encoding an NF-κB p65-rTetO fusion protein comprising one or more transactivation domains (TAD) of human NF-κB p65 fused to a reverse Tet operator (rTetO) binding domain; a second polynucleotide comprising a Tet operator region (TetOR) for providing inducible expression of one or more transgene(s) operatively linked thereoto; and a third polynucleotide comprising a promoter directing transcription of p65-rTetO from a first strand of DNA, where the p65-rTetO is configured to induce transcription of a transgene of interest operatively linked to the TetOR in the presence of tetracycline or doxycycline (Dox) from an opposite strand of DNA.

This invention belongs to the field of water treatment technology, specifically disclosing a method for treating tetracycline-containing wastewater based on manganese oxide-modified biochar. The invention involves mixing manganese oxide-modified biochar, hydrogen peroxide, and tetracycline-containing wastewater to obtain a mixed solution, which is then reacted to treat the tetracycline-containing wastewater. The mass concentration of the manganese oxide-modified biochar in the mixed solution is 1-2 g / L. This invention utilizes manganese oxide-modified biochar for adsorption-synergistic Fenton-like reactions to remove typical antibiotic tetracyclines from water, exhibiting excellent tetracycline adsorption and catalytic performance.

This invention discloses a method for preparing a Bi3O4Br catalyst for the efficient degradation of tetracycline, comprising the following steps: S1, mixing bismuth nitrate and potassium bromide in an aqueous solution at room temperature, stirring, and filtering after the reaction to obtain a precipitate; S2, washing and drying the obtained precipitate to obtain a BiOBr precursor; S3, placing the obtained BiOBr precursor in a sodium hydroxide solution of a certain concentration and reacting at a certain temperature to obtain the Bi3O4Br catalyst. Experimental results show that the Bi3O4Br catalyst has a larger specific surface area and more photocatalytic active sites than pure Bi3O4Br, and has a higher oxygen vacancy (OV) concentration, exhibiting high catalytic activity in the photocatalytic degradation of tetracycline. This photocatalyst has broad practical value and application prospects.

The application relates to the technical field of wastewater treatment, and discloses an expanded graphite catalyst for degrading chemical pharmaceutical wastewater and a preparation method. In the application, 2,2'-diamino-N-(hydroxypropyl trimethyl ammonium chloride) diethylamine is used to carry out an amidation reaction with carboxyl groups on the surface of oxidized expanded graphite, so as to bond and introduce active functional groups such as amino groups, quaternary ammonium salts and hydroxyl groups on the surface of the expanded graphite; then, through high-temperature hydrothermal reaction, zinc oxide particles are uniformly generated in the expanded graphite, and the expanded graphite catalyst is obtained. The active groups such as the hydroxyl groups of the expanded graphite catalyst form hydrogen bonds and other interactions with tetracycline hydrochloride, so that the adsorption and removal rate of the tetracycline hydrochloride is improved. The zinc oxide particles are uniformly grown in the expanded graphite matrix and are not prone to agglomeration, and a large number of photocatalytic active sites are exposed, so that the expanded graphite catalyst has better photocatalytic degradation performance on the tetracycline hydrochloride.

The invention relates to the field of pesticide preparations, and discloses a sterilization composition containing tetramycin and Saisentong as well as a preparation method and application of the sterilization composition. Tetramycin and Saisentong serve as active components of the composition, and a dual-structure composite lignin derivative system serves as a functional carrier; the system is composed of high-molecular-weight modified lignosulfonate and specific lignin phenol fragments with low polymerization degree. The high-molecular-weight component forms a physical barrier on the surfaces of active component particles, so that the storage stability and the application safety of the preparation are improved; the low-polymerization-degree component can be degraded by an extracellular enzyme secreted by citrus canker pathogen, so that the targeted release of the active component at the focus is realized. The composition disclosed by the invention effectively reduces the decomposition rate of the active components and the phytotoxicity risk to crops, and meanwhile, the field control effect on the citrus canker is remarkably improved. The composition provides an efficient and safe new choice with a targeting effect for chemical prevention and treatment of citrus canker.

The invention discloses a glucose derived carbon modified magnetic metal oxide catalyst as well as a preparation method and application thereof. According to the catalyst, glucose is taken as a carbon source, spinel manganese ferrite MnFe2O4 nanoparticles are uniformly anchored on the surface of a porous carbon skeleton through a hydrothermal-calcination process, the saturation magnetization reaches 21.21 emu / g, and rapid separation can be realized in an external magnetic field within 5 seconds. The catalyst is applied to activation of peracetic acid PAA for oxidative degradation of tetracycline TC. The degradation reaction conditions are as follows: the TC initial concentration is 10 mg / L, the PAA concentration is 200 mu M, the catalyst addition amount is 0.1 g / L, the initial pH is 3.0-9.0, the reaction time is 30 minutes, and the TC removal rate is greater than or equal to 97%. The catalyst is cheap in raw materials, simple and convenient to prepare, magnetically recoverable, wide in pH adaptation and free of secondary pollution, and has large-scale preparation and engineering application potential.

The invention discloses a copper slag derived microsphere composite catalyst which is prepared by the following steps: crushing and screening dried copper slag, mixing copper chloride and the copper slag, adding the mixture into an oxalic acid solution, uniformly stirring and mixing to obtain slurry, dropwise adding the slurry into silicone oil, stirring to form balls, aging at 55-65 DEG C for 12 hours, collecting the balls, and calcining at 500-600 DEG C for 2-4 hours to obtain the copper slag derived microsphere composite catalyst. And putting the calcined product into a thioacetamide-ethylene glycol solution, uniformly mixing, carrying out a hydrothermal reaction at 150-170 DEG C for 12 hours, carrying out solid-liquid separation, and drying the solid, the catalyst disclosed by the invention shows excellent PMS activation and degradation effects on oxytetracycline hydrochloride, tetracycline hydrochloride, chlortetracycline hydrochloride, methylene blue and methyl orange; the invention provides a new solution for solving the problem of secondary pollution caused by the copper slag and the problem of water environment pollution caused by antibiotic organic pollutants.

The application belongs to the technical field of tetracycline degradation, and discloses a preparation method of a cathode material for electrocatalytic degradation of tetracycline and application thereof, and solves the technical problems of poor tetracycline degradation effect, short service life of the catalyst and difficulty in reuse of the powdery catalyst in the prior art. The preparation method of the cathode material for electrocatalytic degradation of tetracycline comprises the following steps: configuring a solution containing soluble nickel salt, soluble iron salt and urea; loading the solution and a porous carrier into a reaction kettle for heat treatment; cleaning and drying the porous carrier after heat treatment to obtain a precursor; and performing annealing treatment on the precursor to obtain the cathode material for electrocatalytic degradation of tetracycline. The preparation method of the cathode material for electrocatalytic degradation of tetracycline has simple process, low cost and easy industrial production, and the obtained cathode material is convenient to use and regenerate, has long service life, can efficiently catalyze and activate PMS in an electrochemical environment, and improves the degradation efficiency of tetracycline.

The present disclosure provides a modified rep-cap plasmid containing a tetracycline inducible expression system, which can be used to produce a recombinant AAV1 vector.

Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.

The invention discloses a treatment method and device for degrading tetracycline in soil. The device comprises a plasma generator, a plasma spray gun, an oil-free air compressor, a pneumatic triplet (provided with an air filter, a pressure reducing valve and an atomized lubricator), a gas conveying system, a reactor and the like. The plasma generator outputs high-frequency and high-pressure energy to excite and control generation of low-temperature plasmas in a nozzle steel pipe of the plasma torch, and the low-temperature plasmas are jetted into the reactor under the assistance of compressed air. The treatment method comprises the following steps: uniformly placing the quartz sand in the barrel type reactor, adjusting the distance between the spray gun and the quartz sand, adjusting the gas velocity and the current, and carrying out discharge treatment. The tetracycline in the soil can be effectively degraded, the degradation rate can reach 98% or above, the method is simple, operation is easy and convenient, and the operation effect is good.

The invention discloses a nitrogen-doped carbon catalyst based on weathered coal humic acid as well as a preparation method and application of the nitrogen-doped carbon catalyst. According to the method, weathered coal humic acid is used as a carbon precursor, the carbon precursor and a specific nitrogen source are mechanically ground and mixed according to the equal nitrogen proportion, and the nitrogen-doped carbon catalyst is prepared after high-temperature calcination and acid pickling. The catalyst is used for activating peroxymonosulfate (PMS) to degrade tetracycline, and under the conditions that the dosage of the catalyst is 0.2 g / L and the concentration of the PMS is 1.0 mM, the degradation rate of 20mg / L tetracycline in 30 minutes exceeds 85%. The synergistic effect of inherent trace iron in humic acid and an external nitrogen source is utilized, and high-activity sites are formed in situ in the pyrolysis process; dry grinding is adopted in the process, additional metal sources and solvents are not needed, low-cost and environment-friendly preparation of the efficient heterogeneous catalyst from waste resources is achieved, and a new material is provided for degradation of organic pollutants.

The invention discloses a FeCoY-MOF / BiOBr composite material as well as a preparation method and application of the FeCoY-MOF / BiOBr composite material. The FeCoY-MOF / BiOBr composite material comprises a FeCoY-MOF material and BiOBr particles deposited on the surface of the FeCoY-MOF material, wherein the FeCoY-MOF material is an MOF material obtained by taking pyridine-2, 3-dicarboxylic acid as a ligand and coordinating the pyridine-2, 3-dicarboxylic acid with Co < 3 + >, Fe < 3 + > and Y < 3 + > ions. According to the invention, the transfer of photon-generated carriers can be promoted, and the separation efficiency of the photon-generated carriers is improved, so that the performance of photocatalytic degradation of organic pollutants is improved, and tetracycline can be efficiently subjected to photocatalytic degradation under the irradiation of visible light.

The present application relates to the new use of Baotouweng decoction in the synergistic antibacterial effect of ceftriaxone, tetracycline and amikacin antibiotics. In the preparation of the composition or compound preparation, the dosage ratio of Baotouweng decoction and ceftriaxone, tetracycline and amikacin is between 6400:1-12800:1. The FIC index of Baotouweng decoction combined with ceftriaxone, amikacin or tetracycline is 0.1875-0.375, which is less than 0.5, that is, Baotouweng decoction combined with ceftriaxone, amikacin or tetracycline has synergistic antibacterial effect. The present application can effectively reduce the dosage of ceftriaxone, amikacin or tetracycline, and the MIC value of Baotouweng decoction combined with ceftriaxone, amikacin or tetracycline is reduced by 2-16 times compared with that of single use. Baotouweng decoction can be used as an antibacterial drug resistance reversal agent to improve the antibacterial therapeutic effect under the condition of reducing the dosage of antibacterial drugs.

The invention discloses a one-dimensional ring chain manganese coordination polymer as well as a preparation method and application thereof, and belongs to the technical field of complex synthesis and fluorescence detection. The preparation method comprises the following steps: reacting a bivalent manganese salt and 2-{2-[5-(4-pyridyl)-1H-1, 2, 4-triazole-3-yl] phenoxy} benzoic acid in a solvent, so as to prepare the one-dimensional ring chain type manganese coordination polymer. A solvothermal method is adopted for synthesis, the synthesis process is simple, the efficiency is high, the conditions are mild, and the obtained coordination polymer has good crystal stability and thermal stability, shows high-specificity and sensitive detection performance on furacilin and tetracycline, has application potential as an NFZ and TC specific fluorescent probe, and has wide application prospects. The problem that a rapid, convenient and economical nitrofurazone and tetracycline detection method is lacked in the prior art is solved, and experimental data and theoretical support are provided for designing and developing efficient fluorescent sensing materials for antibiotic pollutants.

The invention discloses a tylosin sensing biosensor, a construction method thereof and MphR mutant protein based on the tylosin sensing biosensor, and belongs to the technical field of gene engineering. The technical problem to be solved by the invention is how to detect tylosin. In order to solve the technical problem, the invention provides the biosensor for sensing tylosin, the biosensor can express an MphR31D1 protein and / or a coding gene containing the MphR31D1 protein, and the MphR31D1 protein can be a protein with an amino acid sequence of SEQ ID NO: 1. The invention also provides a preparation method of the biosensor, and application of the MphR31D1 protein and related biological materials thereof in detection of tylosin. According to the invention, escherichia coli Top10 is taken as a chassis bacterium, a macrolide compound transcriptional regulation factor MphR is taken as a starting template, and the tylosin whole-cell biosensor is successfully constructed through protein directed evolution.

This invention discloses a palladium / ruthenium / two-dimensional monolayer titanium carbide macene nanosheet / three-dimensional nickel foam composite electrode, its preparation method, and its application. Belonging to the field of electrochemical materials technology, it addresses the problem of the lack of high-efficiency, high-degradation, and economical electrode materials in existing technologies, which limits the development of electrocatalytic degradation of antibiotics. The palladium / ruthenium / two-dimensional monolayer titanium carbide macene nanosheet / three-dimensional nickel foam composite electrode of this invention comprises, from the inside out, a nickel foam matrix, a two-dimensional monolayer titanium carbide macene nanosheet intermediate layer, a ruthenium intermediate layer, and a palladium layer. Using the palladium / ruthenium / two-dimensional monolayer titanium carbide macene nanosheet / three-dimensional nickel foam composite electrode as the working electrode, tetracycline-containing wastewater is degraded by electrochemical oxidation. It can efficiently degrade tetracycline in wastewater without causing secondary pollution to water bodies, thus achieving the goal of low-cost environmental protection and water conservation.

Tetracycline derivatives and their use as a medicament. In particular, the tetracycline derivatives may be used in the treatment or the prevention of a disease, such as amyloidosis, pain, neurodegenerative diseases and neuroinflammatory diseases, in which the tetracycline derivatives or pharmaceutical compositions including these compounds are administered to a subject in need thereof.

The application discloses application of tegaserod maleate in preparation of an antibacterial drug synergist, and proves that the tegaserod maleate can produce a synergistic antibacterial effect with a plurality of commonly used antibacterial drugs (including tylosin, tetracycline, enrofloxacin, ampicillin and the like), can significantly enhance the antibacterial activity of the antibacterial drugs on gram-negative bacteria, and reduce the drug resistance of bacteria to the antibacterial drugs; the antibacterial composition composed of the tegaserod maleate and the antibacterial drugs can be used for preparing a drug for treating escherichia coli infection, and the synergistic antibacterial mechanism is mainly to destroy the inner and outer membrane permeability of bacteria, regulate the proton motive force of bacteria, inhibit the activity of bacterial efflux pumps, interfere with the energy metabolism homeostasis of bacteria and induce the bacteria to produce oxidative stress. The application provides a new technical strategy for the treatment of clinical escherichia coli infection, and has important clinical application value and industrialization potential.

This invention relates to the field of tetracycline detection technology, specifically disclosing an iron porphyrin hydrogen-bonded organic framework nanozyme, its preparation method, and its applications. The iron porphyrin hydrogen-bonded organic framework nanozyme comprises an iron porphyrin hydrogen-bonded organic framework, gold nanoparticles, and a tetracycline nucleic acid aptamer. The gold nanoparticles are non-covalently loaded onto the surface and pores of the iron porphyrin hydrogen-bonded organic framework, and the tetracycline nucleic acid aptamer and gold nanoparticles are connected by coordination covalent bonds. The iron porphyrin hydrogen-bonded organic framework nanozyme exhibits peroxide-like nanozyme activity, catalyzing the oxidation of the chromogenic substrate TMB in the presence of H₂O₂ to detect tetracycline content. By introducing the hydrogen-bonded organic framework and the tetracycline nucleic acid aptamer, the detection specificity is improved, achieving highly sensitive, highly selective, and rapid detection of tetracycline. The colorimetric sensor constructed based on the iron porphyrin hydrogen-bonded organic framework nanozyme provides a new method for rapid and visual detection of tetracycline in feed.

This invention discloses a rapid method for detecting CTCs, belonging to the field of tetracycline detection technology. The invention uses a fluorescence spectrometer to measure the fluorescence intensity of the test solution containing fluorescent probes PEI-CuNCs and a surfactant. Compared with the fluorescence intensity of PEI-CuNCs, if a new blue fluorescence emission band appears at 425 nm and the blue-green fluorescence at 500 nm decreases, then the test solution contains CTCs. The detection method of this invention has advantages such as simple operation, speed, high sensitivity, good selectivity, low detection limit, and low cost. It does not require large-scale instruments or professional operators, and shows good spiked recovery rate in actual water sample testing, with reliable detection results and excellent practicality.