514 results about "Tetracycline" patented technology

The invention discloses an organic wastewater adsorbent as well as a preparation method and application thereof, and belongs to the technical field of sewage treatment. Comprising the following steps: carrying out nitration reaction on styrene porous microsphere resin, and then carrying out reduction reaction to obtain amino-modified porous microsphere resin; the preparation method comprises the following steps: carrying out polymerization reaction on high-nitrogen-content amino organic small molecules and aldehyde group small molecules under the action of a basic catalyst in an adsorption polymerization manner to generate a nitrogen-doped organic porous polymer, and coating the surface of amino-modified porous microsphere resin with the nitrogen-doped organic porous polymer to obtain the organic wastewater adsorbent. The porous microsphere resin adsorbent with large adsorption capacity and high organic matter removal rate is synthesized by using the carrier advantage of styrene microsphere resin and introducing a porous heteroatom polymer on the microsphere resin. When the adsorbent is used, the adsorbent is directly added into an organic wastewater solution, and the removal rate of bisphenol A, aniline and tetracycline can reach 90% or above.

The invention discloses an application of Lactobacillus plantarum in at least one of the following items: a1, an application in improving the silage quality of silage, a2, an application in improving the silage quality, a3, an application in improving the silage quality, a4, an application in improving the silage quality, and a5, an application in improving the silage quality. A2, application in preparation of silage; a3, application in preparation of a silage additive; the strain name of the lactobacillus plantarum is LA2, the lactobacillus plantarum is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the lactobacillus plantarum is CGMCC No. 33484. According to the invention, the lactobacillus plantarum or the microbial inoculum thereof or the silage additive thereof is added into the silage for the first time, and tetracycline resistance genes in the silage can be remarkably reduced; after the lactobacillus plantarum or the microbial inoculum thereof or the silage additive thereof disclosed by the invention is added, the generation and residue of tetracycline resistance genes in feed can be reduced, the propagation of the tetracycline resistance genes in a food chain is reduced, the safety of forage grass is ensured, and the damage to animals, environment and human bodies is reduced; and the drug resistance of human pathogenic bacteria is reduced while the health level of animals is improved.

The invention discloses a carbon quantum dot / metal organic framework composite material as well as a preparation method and application thereof, and the method is characterized in that carbon quantum dots derived from waterborne polyurethane are embedded into a zeolite imidazate framework 8 to prepare the carbon quantum dot / metal organic framework composite material. The composite material can be used as a ratio type fluorescent probe for trace detection of tetracycline, a dual-emission fluorescence signal of the probe is derived from tetracycline which quenches blue fluorescence of puCDs at 450 nm through an inner filter effect, and the coordination effect between Zn < 2 + > and tetracycline triggers an aggregation-induced emission effect, so that new fluorescence emission is generated, and the detection sensitivity is improved. The intensity of the two signals changes in proportion to the concentration of tetracycline, the wide linear concentration detection range and the low detection limit are achieved, the probe has the high recovery rate and the large adsorption capacity in detection, the problems that a traditional detection method is insufficient in sensitivity, poor in anti-interference capacity, high in cost and the like are solved, and the application prospect is wide. A new thought is provided for constructing a ratio type fluorescent probe with a removal function.

The present invention relates to the field of environmental protection and discloses a method for removing tetracycline from water. The method uses an iron single-atom material to adsorb tetracycline in water. The iron single-atom material is prepared according to the following steps: (1) mixing ethanol, dimethylformamide, ammonia water, and water to obtain a mixed solution; (2) mixing zinc chloride, iron triacetylacetonate, and triazole with the mixed solution, stirring and reacting, to obtain an iron-doped metal-organic framework material; and (3) pyrolyzing the iron-doped metal-organic framework material at 850 to 950° C. under a protective gas atmosphere to obtain the iron single-atom material. The method provided by the present invention can be applied in complex water environments and has great significance for environmental protection. At the same time, the present invention proposes for the first time the use of an iron single-atom material as an adsorbent for adsorbing tetracycline in water, providing a new application for the iron single-atom material.

The invention belongs to the technical field of biological materials, and particularly relates to a preparation method of a KOH activated fungal mycelium biochar / chitosan composite material. According to the preparation method disclosed by the invention, Phanerochaete chrysosporium mycelium is used as a carbon source, and KOH chemical activation and chitosan surface modification are sequentially carried out, so that the charcoal / chitosan composite material CHKBC is prepared. The CHKBC material prepared by the method is large in specific surface area, developed in pore structure, rich in mesopores and excellent in adsorption performance and regeneration performance; the specific surface area is up to 3650-3920m < 2 > / g, the average pore size is 2-4nm, and both the specific surface area and the average pore size are higher than those of precursor biochar and activated biochar; the maximum adsorption capacity of tetracycline TC is 650-690 mg / g, which is far higher than that of KBC and BC. After five times of recycling, the average regeneration efficiency is higher than 90%, and the regeneration performance is good.

The invention provides a device and a method for detecting antibiotics in aquaculture water, and belongs to the technical field of environmental pollutant detection. According to the device disclosed by the invention, a Fe3O4 (at) GO magnetic nano adsorption material is packaged in a micro-fluidic chip reaction chamber, and a magnetic sticker is innovatively adopted to realize immobilization and replaceable design of an adsorbent; the integrated electromagnetic oscillation module drives the adsorbent to vibrate in the microchannel, and the mass transfer capture efficiency of antibiotics such as sulfonamides, quinolones and tetracyclines is remarkably improved. According to the method, an adsorption-elution-detection integrated process is initiated for the first time, the pretreatment time is shortened to be within 10 minutes from the hour level, synchronous detection of 0.01-5 [mu] g / L ultra-trace multi-component antibiotics in 5-10 [mu] L of a water sample is achieved, compared with a traditional method, the detection precision is remarkably improved, the matrix interference resistance is high, and the method is suitable for large-scale popularization and application. The method is suitable for real-time online monitoring of multiple antibiotic residues in the aquaculture environment.

The invention discloses a composite adsorbent for removing tetracycline in wastewater and a preparation method thereof, and relates to the field of wastewater treatment.The preparation method comprises the following steps that gasified slag and corn roots are pretreated and then mixed and pyrolyzed to prepare a magnetic biochar substrate, the magnetic biochar substrate is dispersed in a solvent, copper salt and organic ligands are added, and the magnetic biochar substrate is obtained; and collecting products through an external magnetic field to obtain the composite adsorbent for removing tetracycline in wastewater. A copper-based metal organic framework material grows in situ on a gasified slag / corn root biochar substrate, and the specific surface area of the material is increased by using a highly ordered porous structure of MOF; through the combined action of various mechanisms, the adsorbent shows extremely high adsorption capacity and good selectivity on tetracycline molecules.

The invention discloses a P.megaterium strain with stress resistance, growth promotion and environmental restoration functions and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M 2025912, and the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC NO: M 2025912; the Pristia megaterium XT106 provided by the invention is a strain capable of oxidizing manganese to form a biological manganese oxide, and the biological manganese oxide can adsorb and remove heavy metals (Cu, Sb, Pb, Zn, Cd and Cr) and degrade antibiotics (tetracycline and ciprofloxacin). The strain can move, tolerate acid-base, high-salt, phenanthrene and sulfamethoxazole environments, has the capability of generating a biological membrane, and can generate hydrogen sulfide, adsorb / fix and remove heavy metals (Cd, Pb, Zn, Sb and Cu) and promote plant growth.

The invention discloses a tetracycline hydrochloride-containing wastewater treatment method in the field of wastewater treatment, which comprises the following steps: introducing tetracycline hydrochloride-containing wastewater into a reactor, adding a multilevel structure iron and iron sulfide composite carbon material, and adjusting the system to a nearly neutral condition; then adding potassium peroxymonosulfate composite salt, starting a direct current system, and carrying out catalytic degradation reaction under specific current density; and finally recovering the catalyst through magnetic field separation. The preparation method comprises the following steps: grinding pyrite and hematite, ball-milling and mixing the ground pyrite and hematite with orange peel powder and sodium hydroxide, and carrying out microwave pyrolysis, acid washing and drying, hydrogen peroxide surface treatment and the like to obtain a final product. According to the method, efficient degradation of tetracycline hydrochloride under the neutral condition is achieved, the catalyst can be magnetically recycled, secondary pollution is avoided, and the method has the advantages of being low in cost, easy and convenient to operate, environmentally friendly and the like.

The invention provides a fluorenyl alcohol derivative which can be used as an antibiotic adjuvant with a broad-spectrum synergistic effect. According to the compound, bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are taken as targets, and a series of fluorenyl alcohol derivatives targeting the bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are obtained through screening. The preferable compound WTU-15 can improve the antibacterial activity of antibiotics such as polymyxin, cefepime, tetracycline and the like on negative bacteria such as sensitive and drug-resistant escherichia coli, salmonella, klebsiella pneumoniae, acinetobacter baumannii and the like, and can also improve the in-vivo treatment effect of cefepime on mice infected by the drug-resistant acinetobacter baumannii. And the visceral organs of the mice survived after administration have fewer bacteria, and the mice are better after being healed. Normal physiological and visceral organ functions of the mouse are not affected by single and continuous administration of the WTU-15.

The invention discloses a nucleic acid aptamer TET-HeR of tetracycline and application of the nucleic acid aptamer TET-HeR, and belongs to the technical field of nucleic acid aptamers. The nucleic acid aptamer TET-HeR of the tetracycline is a combination of an aptamer TET-A1 and an aptamer TET-C1, the nucleotide sequence of the aptamer TET-A1 is as shown in SEQ ID NO.5, and the nucleotide sequence of the aptamer TET-C1 is as shown in SEQ ID NO.7. The nucleic acid aptamer TET-HeR of the tetracycline is a combination of the aptamer TET-A1 and the aptamer TET-C1. The invention further discloses the application of the nucleic acid aptamer TET-HeR of the tetracycline in detection of the tetracycline. The affinity and dissociation constant of the nucleic acid aptamer TET-HeR of the tetracycline and the tetracycline is 62.7 nM, and the nucleic acid aptamer TET-HeR of the tetracycline has high affinity; the compound has no obvious affinity to tetracycline analogues such as aureomycin and doxycycline, has weak affinity to oxytetracycline, and has good specificity; the method can be used for specific detection of tetracycline.

The invention provides a monatomic cobalt-based composite catalyst, a preparation method of the monatomic cobalt-based composite catalyst and application of the monatomic cobalt-based composite catalyst to degradation of antibiotics by activating peroxymonosulfate, and belongs to the technical field of advanced oxidation. The method comprises the following steps: mixing biomass powder and water to obtain a biochar suspension, adding cobalt nitrate hexahydrate into the biochar suspension, centrifuging the mixed solution, collecting residues, and drying to obtain a sample; and pyrolyzing the sample in a protective gas atmosphere, taking out, cooling, washing, and drying to obtain the monatomic cobalt-based composite catalyst. The cobalt-based catalyst prepared by the invention has high specific surface area, abundant pore structures and a large number of active sites, and is beneficial to activation of PMS and degradation of pollutants; the cobalt-based composite catalyst prepared by the method is used for activating peroxymonosulfate to degrade tetracycline, and the removal rate of tetracycline in a solution is greater than 99% after reaction is carried out for 20 minutes under a dark condition.

The invention belongs to the technical field of biology, and particularly relates to bifidobacterium longum subsp.infantis FMBL B250020GXY for metabolizing breast milk oligosaccharide and application of the bifidobacterium longum subsp.infantis FMBL B250020GXY, the bifidobacterium longum subsp.infantis FMBL B250020GXY is preserved in China Center for Type Culture Collection on September 1, 2025, and the preservation number is CCTCC M 20251931; three kinds of breast milk oligosaccharides, namely 2 '-fucosyllactose (2'-FL), lactose-N-neotetraose (LNnT) and lactose-N-tetraose (LNT), can be metabolized; plant source carbohydrates such as fructo-oligosaccharide and synanthrin can be metabolized; the compound has a relatively strong capability of removing DPPH and ABTS free radicals; a good inhibition effect is achieved on common pathogenic bacteria; good tolerance to acid and cholate is achieved; the strain is sensitive to gentamicin, streptomycin, tetracycline, chloramphenicol and vancomycin; the compound can be used for preparing antioxidant products, medicines for inhibiting pathogenic bacteria, infant foods and fermented foods, and has a wide application prospect.

The invention relates to the technical field of photocatalysts, and particularly discloses modified bismuth molybdate as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a homogeneous solution A containing a bismuth source; sO4 < 2-> and a molybdenum source are dispersed in a solvent according to the molar mass ratio of 1: 1-1: 10, and a homogeneous solution B is obtained; uniformly mixing the homogeneous solution A and the homogeneous solution B to obtain a solution C; and carrying out a hydrothermal method on the solution C to obtain the modified bismuth molybdate. By doping SO4 < 2-> into bismuth molybdate, the physicochemical properties of bismuth molybdate are optimized from multiple aspects, the photocatalytic activity of bismuth molybdate is improved, and excellent performance is achieved in the aspect of photocatalytic degradation of tetracycline in actual wastewater. The prepared modified bismuth molybdate not only can efficiently utilize visible light, but also is rich in oxygen vacancies on the surface, has high specific surface area, strong adsorbability and efficient photon-generated carrier separation efficiency, shows strong redox activity, and remarkably promotes pollutant degradation.

The invention relates to a carbon quantum dot-ZIF-8 compound capable of being used for sewage detection as well as a preparation method and application of the carbon quantum dot-ZIF-8 compound. Through cooperation of the ZIF-8 and the carbon quantum dots, the carbon quantum dot-ZIF-8 compound is allowed to realize high-precision detection of tetracyclines through a double-peak ratio method.

The present invention provides a method for enhancing the removal of resistance genes and promoting humification in aerobic composting. The method comprises the following steps: mixing livestock and poultry manure with a composting auxiliary material, adjusting the moisture content to 55%-65%, and adding a MnFe2O4 additive to obtain a composting raw material; aerobically composting the material, turning the compost every 2-3 days during a temperature rise period and a high temperature period, and every 7 days during a temperature fall period and a mature period, with the aerobic composting time being 20-30 days. Compared with a conventional composting method, the relative abundances of sulfonamide, tetracycline, macrolide, and aminoglycoside resistance genes in the mature compost obtained by the method are reduced by 60%-73%, 50%-57%, 20%-80%, and 45%-66%, respectively, and the humic acid (HA) content is increased by about 15%. Meanwhile, the method achieves efficient harmlessness and resource utilization of organic solid waste, and has the potential for large-scale production.

A system for the synthesis of a cost-effective photocatalyst based on the FeOOH / CuBi2O4 heterostructure, consisting of: a) a CuBi2O4 synthesis plant for the production of CuBi2O4 (CBO) microspheres from Bi(NO3)3·6H2O and Cu(NO3)2.3H2O precursors; b) a heterostructure formation unit is configured to deposit FeOOH nanoparticles onto an outer surface of the CBO microspheres to form an FeOOH / CBO heterostructure; and c) a processing unit configured to wash and dry the FeOOH / CBO heterostructure to obtain the photocatalyst.

A method for enhancing resistance gene removal and promoting humification in an aerobic compost, which method comprises mixing livestock and poultry manure with compost auxiliary materials, adjusting the water content, adding an MnFe2O4 additive, and then performing aerobic composting for 20-30 days. Compared with conventional composting methods, the mature compost product obtained by means of the method exhibits a 60%-73% reduction in the relative abundance of sulfonamide resistance genes, a 50%-57% reduction in tetracycline resistance genes, a 20%-80% reduction in macrolide resistance genes, and a 45%-66% reduction in aminoglycoside resistance genes, and shows approximately a 15% increase in humic acid HA. This method achieves both efficient harmless treatment and resource utilization of organic solid waste.

The invention provides preparation of an S / N co-doped modified biochar composite material and application of the S / N co-doped modified biochar composite material in activated persulfate resource degradation and removal of antibiotics, belongs to the technical field of wastewater treatment, and aims to efficiently degrade and remove antibiotics in wastewater and avoid environmental risks of a metal catalyst at the same time. The method is a green, environment-friendly, economical and efficient water treatment method; the preparation method comprises the following specific steps: S1, mixing and grinding waste crop biomass and metal salt to prepare modified biochar; s2, mixing and grinding the modified charcoal and a sulfur-containing compound; s3, performing high-temperature pyrolysis on the ground mixture to obtain an S / N co-doped modified charcoal composite material, and using the S / N co-doped modified charcoal composite material as a persulfate catalyst to effectively degrade and remove tetracycline in polluted wastewater; the S / N co-doped modified biochar composite material prepared by the invention effectively solves the problem of secondary utilization of waste crops, mainly improves the degradation and removal efficiency of tetracycline and realizes resource conversion of tetracycline.

The invention relates to the technical field of biology, in particular to a method for producing a platelet quality control product by using iPS cells and the platelet quality control product, and the method comprises the following steps: controlling overexpression of a specific gene in the iPS cells by using a gene editing technology to obtain an iPS cell line containing the specific iPS cells; a differentiation procedure is started by adding a culture medium containing a tetracycline derivative, and meanwhile, a fibroblast growth factor 2 and a bone morphogenetic protein 4 are added to promote mesoderm differentiation; growth factors and tetracycline derivatives are added to induce overexpression of specific gene segments and promote formation of specific megakaryocytes; adding an AhR antagonist and a ROCK inhibitor into the recovered specific megakaryocyte, and culturing to obtain platelets; and screening a platelet standard substance based on platelet functions and preparing the platelet standard substance into a quality control substance.

The invention provides a Z-type heterojunction material for synchronously removing phosphorus and tetracycline in sewage. The material is composed of a hexagonal flaky nano magnesium-aluminum-iron hydrotalcite matrix with the size of 30-100 nm and a metal oxide growing on the surface. The preparation method of the material comprises the following steps: carrying out hydrothermal treatment on magnesium-aluminum-iron hydrotalcite and trimesic acid in N-N dimethylformamide liquid, growing a metal organic framework compound on the surface of the magnesium-aluminum-iron hydrotalcite in situ through dissolved-out metal ions and trimesic acid, and roasting the metal organic framework compound to obtain the Z-type heterojunction material. The Z-type heterojunction material can synchronously and efficiently remove phosphorus and tetracycline in sewage, the synchronous removal rates of 50 mg of the material to phosphorus and tetracycline are 97.60% and 95.47% respectively in 100 mL of a phosphorus (concentration of 25 mg / L) water sample and a tetracycline (concentration of 50 mg / L) water sample, and the synchronous removal rates of phosphorus and tetracycline are still 87.62% and 85.57% after continuous circulation for five times. The Z-type heterojunction material can be applied to the aspect of phosphorus and tetracycline mixed sewage treatment in the breeding industry.

The invention provides a preparation method and drug detection application of ZIF-8-Fe metal organic framework nano-enzyme, the ZIF-8-Fe metal organic framework nano-enzyme is prepared by adopting a heating reflux method, and peroxidase-like activity and drug detection application of the ZIF-8-Fe metal organic framework nano-enzyme are researched. In the presence of H2O2, the material can catalytically oxidize TMB to generate a blue product and shows good peroxidase activity, and through optimization experiments, proper reaction temperature and pH buffer system and optimal concentrations of ZIF-8-Fe, TMB and H2O2 are determined. Kinetic analysis shows that the affinity of TMB is superior to that of natural HRP, and a colorimetric detection method is established based on the inhibition effect of TC on the catalytic reaction. The method disclosed by the invention is reasonable in linear range, relatively low in detection limit and good in sample recovery rate and relative standard deviation performance, can be used for detecting tetracycline tablets, and shows a potential application value of the ZIF-8-Fe nano-enzyme in the field of drug detection.

The invention discloses a UiO-66 (Ce) / ZnO composite photocatalyst as well as a preparation method and application thereof, and relates to the technical field of photocatalytic degradation of water pollution. The method specifically comprises the following steps: preparing zinc oxide by taking zinc acetate dihydrate, absolute ethyl alcohol and sodium hydroxide as raw materials; and dispersing the obtained zinc oxide in a DMF solution containing terephthalic acid, adding a ceric ammonium nitrate aqueous solution, and carrying out a heating reaction to synthesize the UiO-66 (Ce) / ZnO composite photocatalyst. According to the invention, ZnO and UiO-66 (Ce) are used for constructing a heterojunction for the first time, and the design not only widens the visible light response range, but also significantly improves the charge separation efficiency, thereby greatly enhancing the photocatalytic performance. The preparation process is simple and convenient, and the conditions are environment-friendly. The degradation rate of the obtained composite photocatalyst on tetracycline in waste water under visible light can reach 91.2%, the composite photocatalyst has good recoverability and reusability, a new scheme is provided for efficient degradation of organic pollutants, and the composite photocatalyst has remarkable advantages in the field of environmental protection.

The invention relates to the technical field of photocatalytic materials, in particular to a metal single atom loaded defect carbon nitride catalyst and a preparation method and application thereof. The method comprises the following steps: by taking melamine as a nitrogen source, soluble metal salt as a metal source and ethylenediaminetetraacetic acid as a chelating agent, carrying out freeze drying in a solvent system, calcining in a protective atmosphere, and carrying out thermal polymerization, so as to obtain the metal single atom loaded defective carbon nitride catalyst. The metal in the soluble metal salt is copper, iron or manganese. Precise anchoring and high dispersion of metal ions are achieved through complexing of ethylenediamine tetraacetic acid, a stable metal-N coordination structure is formed, metal agglomeration is avoided, a defect structure is constructed synchronously, and the metal monatomic loading capacity is 1 wt.%-7 wt.%. The catalyst can efficiently catalyze and activate peroxymonosulfate and rapidly degrade antibiotic pollutants such as tetracycline, has the advantages of being low in preparation cost, environmentally friendly, high in catalytic activity and high in stability, and is suitable for the field of water pollution remediation.

The invention belongs to the technical field of antibiotic pollutant degradation, and discloses a method for degrading antibiotic pollutants by using boron-carbon co-regulated nanoscale zero-valent iron as an activating agent, which comprises the following steps: step 1, synthesizing carbon-coated nanoscale zero-valent iron, marked as Fe0-C, through a hydrothermal method and a carbothermic method; and step 2, mixing the Fe < 0 >-C obtained in the step 1 with crystal boron, adding the mixture into sewage containing antibiotic pollutants, and then adding persulfate as an oxidizing agent to degrade the antibiotic pollutants. A boron-carbon co-regulation method is adopted to realize the passivation resistance of the nano zero-valent iron in the whole process from preparation, storage to application, and the nano zero-valent iron is applied to the process of activating persulfate to degrade tetracycline.

The present invention relates to nucleic acids and modified immune cells or precursors thereof, comprising a first polynucleotide encoding an NF-κB p65-rTetO fusion protein comprising one or more transactivation domains (TAD) of human NF-κB p65 fused to a reverse Tet operator (rTetO) binding domain; a second polynucleotide comprising a Tet operator region (TetOR) for providing inducible expression of one or more transgene(s) operatively linked thereoto; and a third polynucleotide comprising a promoter directing transcription of p65-rTetO from a first strand of DNA, where the p65-rTetO is configured to induce transcription of a transgene of interest operatively linked to the TetOR in the presence of tetracycline or doxycycline (Dox) from an opposite strand of DNA.

This invention belongs to the field of water treatment technology, specifically disclosing a method for treating tetracycline-containing wastewater based on manganese oxide-modified biochar. The invention involves mixing manganese oxide-modified biochar, hydrogen peroxide, and tetracycline-containing wastewater to obtain a mixed solution, which is then reacted to treat the tetracycline-containing wastewater. The mass concentration of the manganese oxide-modified biochar in the mixed solution is 1-2 g / L. This invention utilizes manganese oxide-modified biochar for adsorption-synergistic Fenton-like reactions to remove typical antibiotic tetracyclines from water, exhibiting excellent tetracycline adsorption and catalytic performance.

The invention relates to a preparation method of an alumina-loaded iron-aluminum co-doped graphene-like catalyst and application of the alumina-loaded iron-aluminum co-doped graphene-like catalyst in the field of water treatment. The method comprises the following steps: dispersing biomass (such as silkworm excrement, corncob and the like) in water to form a suspension, sequentially adding ferric salt, aluminum salt and a nitrogen source (such as urea, melamine and the like), adjusting the pH value, impregnating alumina pellets, drying, and roasting at high temperature in an inert atmosphere to prepare the immobilized catalyst. According to the catalyst, iron-aluminum co-complexed nitrogen-doped graphene is loaded on alumina pellets, and the catalyst has high specific surface area and active sites. The catalyst disclosed by the invention is suitable for degrading refractory organic pollutants (such as tetracycline, bisphenol A and ciprofloxacin) in water, can realize rapid degradation within 30 minutes through a synergistic effect with microorganisms, and is excellent in long-term operation stability (for example, the tetracycline removal rate is kept 100% for 106 days). The immobilized design of the catalyst facilitates separation and recovery, avoids secondary pollution, and is suitable for industrial water treatment. The matched curing bed reactor controls contact reaction of pollutants and a catalyst through a peristaltic pump, and continuous and efficient treatment is achieved. The method has the advantages of low raw material cost, simple process, high catalytic activity and cyclic utilization, and provides an efficient and environment-friendly solution for the treatment of organic polluted water.

The invention discloses a core-shell structure microneedle patch loaded with tetracycline antibacterial drugs and simvastatin as well as a preparation method and application of the core-shell structure microneedle patch, and belongs to the field of biomedical materials. An antibacterial drug doxycycline is loaded on a shell structure of a substrate layer and a needle body of the microneedle patch, and a core structure contains simvastatin-loaded polydopamine nanoparticles. The microneedle patch can release antibacterial drugs in stages, and the number of bacteria at local parts of a focus can be rapidly reduced in a short time through burst release of the antibacterial drugs in the first stage, so that inflammation spreading is controlled; in the second stage, the antibacterial medicine is slowly released, so that the formation of a new plaque biofilm is inhibited for a long time, meanwhile, simvastatin is slowly released, the effect of locally promoting osteogenesis is achieved, and the synergistic effect of antibiosis and bone regeneration is achieved. The compound has a good application prospect in the treatment of chronic periodontitis, especially intractable periodontitis combined with systemic diseases, such as chronic periodontitis combined with diabetes mellitus.

The invention discloses a preparation method of a g-C3N4 / ZnO composite material capable of efficiently degrading tetracycline, and relates to the technical field of preparation of degraded tetracycline, and the preparation method comprises the following steps: preparing materials; uniformly mixing the graphene precursor, the zinc source material, the composite additive and the surface modifier; the mixture is subjected to a hydrothermal reaction, and a g-C3N4 / ZnO composite material is synthesized; and washing and drying the synthesized composite material to obtain the final g-C3N4 / ZnO composite material. The treated g-C3N4 / ZnO composite material is subjected to surface morphology and phase analysis, and it is ensured that the morphology and composition of the material meet the requirements. The specific surface area of g-C3N4 is increased by introducing the graphene precursor, the compounding effect of g-C3N4 and ZnO is enhanced, ZnO particles are synthesized by adopting a hydrothermal method, the photocatalytic activity is improved, efficient tetracycline degradation is achieved, the water treatment requirement is met, the manufacturing cost is reduced, and the method has industrial production potential and wide application prospects.