9 results about "Aminoglycoside" patented technology

The invention relates to polystyrene cation exchange resin as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a dispersing agent in a solvent to obtain a dispersed phase for suspension polymerization reaction, uniformly mixing a reaction monomer, a cross-linking agent, a pore-foaming agent and an initiator, and carrying out suspension polymerization reaction under segmented stirring and segmented temperature change to prepare copolymer microspheres; and putting the dried microspheres into a reaction kettle, swelling, carrying out sulfonation reaction through a variable temperature program on the basis to obtain sulfonated microspheres, and carrying out alkali exchange reaction on the sulfonated microspheres to obtain the final product cation exchange resin. Compared with the prior art, the cation exchange resin preparation method provided by the invention has the characteristics of simple and feasible process, easiness in large-scale production, low cost, high specific surface area, high adsorption capacity and high separation efficiency, and is especially suitable for separating and purifying substances containing amino groups or aminoglycosidic bonds.

The present invention relates to compositions and methods for manufacturing an adjuvant comprising an aminoalkyl glucosaminide phosphate compound or glucopyranosyl lipid adjuvant using a microfluidic device and to related aspects.

This invention provides a small molecule inhibitor targeting the FcεRIγ subunit and its application. It discovers that erythrophenol can act as a small molecule inhibitor targeting the FcεRIγ subunit, thereby inhibiting the occurrence of allergic reactions. This invention confirms the direct binding interaction between erythrophenol and the FcεRIγ subunit using SPR and CETSA techniques, revealing that erythrophenol can target and inhibit the FcεRIγ subunit. Furthermore, this invention finds that erythrophenol can significantly inhibit the release of IgE signal-induced β-aminoglycosidase in mast cells, exhibiting a significant ability to inhibit IgE signal-mediated mast cell degranulation and suppress mast cell activation-mediated allergic reactions. This fully demonstrates that erythrophenol, as an inhibitor targeting the FcεRIγ subunit, holds promise as the first inhibitor to induce FcεRIγ subunit degradation in anti-type I allergic diseases, and has broad application prospects for further use in anti-allergy treatment.

Antibiotic compounds that are reaction products of an antibiotic molecule and a cross-linkable silane molecule are provided which are useful for incorporation into a liquid base coating material. The antibiotic molecule may be a fluoroquinolone, penicillin, cephalosporin, tetracycline, macrolide and / or aminoglycoside, while the cross-linkable silane molecule may be an epoxy-functionalized silane, an aldehyde-functionalized silane and / or a halogenated silane. Coating formulations including the antibioitic compounds and coated substrates which are coated with such coating formulations are also provided.

Described herein is a general solution to 1,2-cis-amino-glycoside synthesis through an iron-catalyzed, exclusively 1,2-cis-selective glycal aminoglycosylation via cooperative atom transfer catalysis. Further described is a 1,2-cis-selective glycal aminoacyloxylation method for 2-amino saccharide synthesis. The methods are effective for a wide variety of glycosyl donors with consistently high stereoselectivity and excellent functional-group compatibility, which facilitates late-stage amino group incorporation for complex-carbohydrate and other biologially-related molecule synthesis.

The invention discloses a supramolecular nano enzyme antagonist with a multi-effect synergistic effect as well as a preparation method and application thereof, and belongs to the technical field of biological nano engineering materials. The preparation method comprises the following steps: firstly driving the formation of a nano assembly through Mannich reaction, in the process, an amino group on an aminoglycoside compound only forms a benzoxazine structure with an A ring of EGCG, while a polyphenol part with metal ion chelating ability on the EGCG still exists, and then introducing selenium ions into a reaction system, so that the selenium-rich nano assembly is obtained. According to the preparation method, selenium ions are added into the nano-assembly and are strongly coordinated with residual polyphenol groups in the nano-assembly, the selenium ions are adsorbed to the surface of the nano-assembly, finally, the selenium ions are reduced into elemental selenium in situ under the reduction of ascorbic acid, and meanwhile, nano-selenium particles are formed in situ due to a nano-confinement effect; therefore, the supramolecular nano-enzyme antagonist with efficient cfDNA capture and ROS removal capabilities at the same time is constructed.

This document discloses conjugated pharmaceutical preparations comprising a targeting moiety (in some embodiments, an aminoglycoside or a related compound) that is directly or indirectly conjugated to a payload moiety (e.g., a regulatory nucleic acid), compositions comprising the conjugated ...

Provided herein is a method for the large-scale manufacture of liposomal drug formulations containing an aminoglycoside such as amikacin having advantageous lipid / drag characteristics. The method utilizes a particular relative flow rate ratio of lipid to drug streams to obtain liposomes with a high aminoglycoside encapsulation efficiency. The resulting liposomal drug formulations advantageously comprise an overall lipid-to-drug weight ratio of less than 1:1.

The application relates to the technical field of intelligent targeted magnetic response micro robots, and discloses a polyphenol-modified magnetic liquid metal-based micro intelligent antibacterial robot and a preparation method thereof.The preparation method comprises the following steps: dissolving polyphenol and an aminoglycoside antibiotic in water, performing a Schiff base reaction to obtain a precursor solution; adding magnetic liquid metal particles into the precursor solution, centrifugally collecting the solid phase after reaction to obtain a precursor; and soaking the precursor in a high agglutinin affinity sugar solution, stirring and reacting, and then centrifugally collecting the solid phase to obtain the polyphenol-modified magnetic liquid metal-based micro intelligent antibacterial robot.The application utilizes the multiple hydrogen bonds of natural polyphenol and the coordination effect of the magnetic liquid metal surface to form a stable interface network, thereby providing a stable support for sugar ligand fixation; meanwhile, tobramycin participates in polyphenol network construction in the form of a Schiff base interaction, realizes the pH-responsive release of the antibiotic, combines and stabilizes mannose, and finally obtains an intelligent targeted antibacterial micro robot.