84 results about "Allergic anti" patented technology

The invention provides kelp fucoidin with low molecular weight and high anti-anaphylaxis as well as a preparation method and application thereof, and belongs to the technical field of food processing. The preparation method comprises the following steps: mixing kelp fucoidin with water to obtain a kelp fucoidin solution; and mixing the kelp fucoidin solution with H2O2 and Vc, reacting, adjusting the pH value, dialyzing and freeze-drying to obtain the kelp fucoidin with low molecular weight and high anti-allergic property. The H2O2-Vc degradation system is innovatively applied to preparation of the low-molecular-weight kelp fucoidin and improvement of the anti-allergic activity of the low-molecular-weight kelp fucoidin. In the degradation process, the chemical composition of the fucoidin is partially changed, but monosaccharide types and functional groups are not influenced. Through multiple ways of cell model and animal model experiments, the degraded laminaria fucoidin is more prominent in anti-allergic activity. Technical support is provided for development of seaweed-derived anti-allergic functional active substances, and high-valued utilization of kelp resources in the fields of functional food and medicines is further promoted.

This invention relates to the field of microbial technology, specifically to a *Lactobacillus plantarum* YYS-B1 strain with hyaluronidase inhibitory activity and its applications. *Lactobacillus plantarum* (… Lactiplantibacillus plants YYS-B1 was deposited at the China General Microbiological Culture Collection Center (CGMCC) on June 12, 2023, with accession number CGMCC No. 27599. This *Lactobacillus plantarum* YYS-B1 exhibits excellent acid and bile salt resistance, enabling it to successfully reach the intestines and exert its probiotic effects. It also demonstrates outstanding anti-allergic, anti-inflammatory, and antioxidant capabilities, specifically exhibiting high hyaluronidase inhibition, strong free radical scavenging ability, and a good inhibitory effect on inflammatory responses caused by allergies. Therefore, it has significant application value and can be used in the development of functional products.

The application provides an extraction method and application of artemisia fiber, and the artemisia fiber is efficiently prepared by the following steps: mild degradation of lignocellulose structure through microbial pretreatment, and dissolution and regeneration in combination with a green solvent system of N-methyl morpholine-N-oxide solution (hereinafter referred to as "NMMO solution"), so that high-value utilization of artemisia waste stems and stalks is realized. The obtained artemisia fiber can retain part of active ingredients from plants, has certain odor removal, antioxidant and anti-allergic potential in food-grade packaging materials and green wallpaper applications, and overcomes defects such as difficult degradation, easy damp and mildew, and single function of traditional packaging materials and wallpapers.

The present application relates to a kind of compositions with anti-inflammatory and anti-allergic effects and its application, and the preparation raw materials of the composition include boletus, phyllanthus and rose apple.The present application uses steam explosion coupling heating reflux preparation to prepare the composition with boletus, phyllanthus, rose apple as preparation raw material, the method not only significantly improves extraction efficiency and biological activity, compared with traditional extraction technology, also avoids the use of organic reagent, more environmentally friendly and safe.

The invention relates to a skin antiallergic composition and a preparation method and application thereof, and the composition is prepared from the following raw materials: sodium cellulose, essence, propylene glycol, a coating solution, a nonionic surfactant and water, the coating solution is prepared by taking modified chitosan microspheres, ascophyllum nodosum extract, chamomile flower extract, centella asiatica extract, anthemis nobilis flower extract, glycerol and water as raw materials, and the modified chitosan microspheres are products obtained by grafting polylactic acid with chitosan. The modified chitosan microsphere can form a nano-micelle with a core-shell structure in a solvent, the ascophyllum nodosum extract, the chamomilla recutita extract, the centella asiatica extract and the anthemis nobilis extract are wrapped in the nano-micelle, the situation that the extracts are degraded or inactivated due to the external environment is avoided, a stable dispersion system can be formed in water, and the stability of the nano-micelle is improved. The plant extract is released after the body surface is coated, and the plant extract and other components synergistically improve the anti-allergic effect of the skin.

The invention relates to the technical field of medical materials, and discloses a preparation method of a multifunctional fiber patch for bone nail fixation postoperative care. The fiber patch adopts a three-layer composite structure design, and comprises an anti-allergic silica gel substrate layer, a drug-loaded nanofiber functional layer and a waterproof breathable layer. The preparation method comprises the following steps: (1) preparing the anti-allergic silica gel substrate layer from platinum cured silica gel and a pressure-sensitive adhesive; (2) preparing a medicine-carrying nanofiber functional layer containing phellinus igniarius polysaccharide through electrostatic spinning; (3) mixing waterborne polyurethane with polytetrafluoroethylene to prepare a waterproof breathable layer; and (4) sequentially compounding the substrate layer, the functional layer and the waterproof breathable layer into the multifunctional fiber patch. The fiber patch has the comprehensive effects of resisting bacteria, resisting inflammation, resisting allergy and easing pain, meanwhile has excellent air permeability and comfort, can effectively promote postoperative wound recovery and reduce infection risks, is particularly suitable for wound nursing after orthopedic internal fixation, and has remarkable clinical application value.

The invention relates to the technical field of collagen dressings, in particular to a moisturizing and repairing collagen dressing and a preparation method thereof. The moisturizing and repairing collagen dressing is prepared from the following components in parts by mass: 10 to 30 parts of recombinant human fibronectin, 10 to 20 parts of recombinant collagen, 5 to 15 parts of beta-glucan, 5 to 10 parts of compound hexanediol, 40 to 50 parts of carbomer, 5 to 15 parts of a flavoring agent, 80 to 120 parts of purified water, 10 to 30 parts of a modified recombinant human III type collagen solution and 10 to 20 parts of a modified chitosan solution. The recombinant human fibronectin disclosed by the invention can be deposited at an injured part to form a blood clot, so that the aim of stopping bleeding is fulfilled, and the subcutaneous tissue is protected; the recombinant collagen has high biological activity and can inhibit inflammation and improve the conditions of pachulosis, damage and the like of the skin; the beta-glucan can generate cytokines, promote healing of skin with laser-dependent dermatitis or barrier damage, and realize anti-allergic and anti-inflammatory effects.

The invention relates to the technical field of cosmetics, and discloses an essential oil composition as well as a preparation method and application thereof. The essential oil composition is prepared from chamomile essential oil, magnolia flower essential oil, lavender essential oil and magnolia flower fermentation product freeze-dried powder. Wherein the magnolia flower fermentation product freeze-dried powder is freeze-dried powder of a product obtained by fermenting a magnolia flower water extract with lactic acid bacteria and saccharomyces cerevisiae; the lactic acid bacteria are lactobacillus plantarum with the serial number of CICC (China General Microbiological Culture Collection Center) 20242; the serial number of the saccharomyces cerevisiae is BNCC 186060. The magnolia flower fermentation freeze-dried powder provided by the invention has very excellent anti-allergic ability, the chamomile essential oil, the magnolia flower essential oil and the lavender essential oil are combined to form the essential oil composition, the allergic reaction can be further relieved, the whole essential oil composition is all natural plant extracts, and the magnolia flower fermentation freeze-dried powder has low irritation and multiple functions and is suitable for large-scale production. The compound is suitable for serving as an active substance of anti-allergic products in the field of cosmetics.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for early and middle stages of bone fracture, a preparation method and application. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25 to 75 parts of radix salviae miltiorrhizae, 12 to 38 parts of flos carthami, 8 to 25 parts of dragon's blood, 10 to 30 parts of radix paeoniae rubra, 25 to 75 parts of radix angelicae pubescentis, 15 to 45 parts of rhizoma corydalis, 12 to 38 parts of rhizoma seu radix notopterygii, 12 to 38 parts of radix angelicae, 10 to 30 parts of rhizoma arisaematis, 25 to 75 parts of rhizoma sparganii, 12 to 38 parts of rhizoma curcumae, 10 to 30 parts of pericarpium citri reticulatae viride, 10 to 30 parts of pericarpium citri reticulatae, 10 to 30 parts of radix aucklandiae, 25 to 75 parts of polyporus umbellatus, 15 to 45 parts of fructus liquidambaris, 12 to 38 parts of cortex phellodendri, 12 to 38 parts of rhizoma atractylodis, the traditional Chinese medicine is prepared from 12-38 parts of radix trichosanthis, 25-75 parts of fructus kochiae, 15-45 parts of fructus cnidii, 12-38 parts of radix dipsaci, 12-38 parts of rhizoma drynariae and 5-20 parts of radix glycyrrhizae. The traditional Chinese medicine composition can promote blood circulation, stop bleeding, relieve swelling and pain, remove blood stasis, promote the circulation of qi, clear away heat, remove dampness and reunion fractures and tendons in the new injury period, and meanwhile is resistant to allergy and high in safety.

The handmade soap contains a lipidosome nano-emulsion compound system, has good film-forming property, can protect sensitive components, can encapsulate active components in traditional Chinese medicinal material extracts which are easy to oxidize, and can resist a strong alkaline environment of the medicated soap, so that the handmade soap has a good anti-allergy effect, and the handmade soap has a good anti-allergy effect and a good anti-allergy effect. The nano-emulsion increases fat-soluble components, improves bioavailability and promotes skin absorption, and the nano-scale particle size (100-200nm) of the liposome and the nano-emulsion can penetrate through the cuticle, so that slow-release delivery is realized, and the drug effect is prolonged. Meanwhile, an artificial moisturizing barrier can be constructed for the skin, and moisture evaporation on the surface of the skin is reduced; the traditional Chinese medicinal material extract has relatively strong bacteriostatic activity and very strong antioxidant activity on pathogenic bacteria and pathogenic fungi. Therefore, the handmade soap disclosed by the invention has the effects of moisturizing, cleaning, inhibiting bacteria, resisting inflammation, resisting allergy and the like, can better protect fragile skin, and can help wounded skin heal at the same time.

The invention discloses a real breathable probiotic ultrathin spill-proof breast pad which comprises a breast pad body, the breast pad body is composed of a surface layer located on the skin-friendly side and an absorber compounded on the surface of the outer side of the surface layer, and on a vertical hierarchical structure, the absorbers are arranged from inside to outside. The absorber comprises a wood pulp fiber non-woven fabric layer, a polymer absorbing layer, a dust-free paper layer and a spunbond non-woven fabric water-repellent layer; on the perspective structure of the plane of the skin-friendly side, the breast pad body comprises an absorption area located in the center area of the body and an embossing area located in the peripheral area of the absorption area, the macromolecule absorption layer corresponds to the absorption area, and the portion, on the skin-friendly side, of the embossing area is provided with silica gel attaching points capable of being attached to the skin and inner release paper covering the embossing area. The outer side surface of the spunbond non-woven fabric water-repellent layer is provided with a back adhesive area used for being attached to brassiere underwear, and the back adhesive area is covered with outer release paper. The anti-galactorrhea pad has the advantages of being ultrathin, high in breathability, low in reverse osmosis, high in absorption, bacteriostatic and antiallergic, has a selectable fixed wearing form, and meets diversified wearing requirements.

The present application relates to the technical field of skin care products, and discloses a composition with the effect of soothing sensitive skin, which is composed of the following components in mass percentage: plant extract 10-12%, skin repair factor 2-3%, jasmine hydrolat 10%, humectant 6-7%, and the balance being water. The composition with the effect of soothing sensitive skin has significant soothing effect, which is close to the soothing effect of common hormone ointments on the market. The composition can significantly reduce inflammatory factors, has good anti-inflammatory effect, simultaneously repairs damaged skin, enhances the moisturizing function, and enhances the skin barrier through the moisturizing and repairing effect. The composition has the effect of resisting anaphylaxis by reducing the content of trypsin and inhibiting the allergic reaction of mast cells. Human patch test and fish embryo development toxicity test prove that the composition with the effect of soothing sensitive skin has no skin adverse reactions and no development toxicity, is mild, safe and non-irritating, and is suitable for preparing skin care products for adults and infants.

This invention provides a small molecule inhibitor targeting the FcεRIγ subunit and its application. It discovers that erythrophenol can act as a small molecule inhibitor targeting the FcεRIγ subunit, thereby inhibiting the occurrence of allergic reactions. This invention confirms the direct binding interaction between erythrophenol and the FcεRIγ subunit using SPR and CETSA techniques, revealing that erythrophenol can target and inhibit the FcεRIγ subunit. Furthermore, this invention finds that erythrophenol can significantly inhibit the release of IgE signal-induced β-aminoglycosidase in mast cells, exhibiting a significant ability to inhibit IgE signal-mediated mast cell degranulation and suppress mast cell activation-mediated allergic reactions. This fully demonstrates that erythrophenol, as an inhibitor targeting the FcεRIγ subunit, holds promise as the first inhibitor to induce FcεRIγ subunit degradation in anti-type I allergic diseases, and has broad application prospects for further use in anti-allergy treatment.

The invention belongs to the technical field of food microorganisms, and particularly relates to a lactobacillus paracasei BHP06 with an anti-allergic function. The preservation number of the Lactobacillus paracasei BHP06 is GDMCC (China General Microbiological Culture Collection Center) No: 66270, and the preservation number of the Lactobacillus paracasei BHP06 is CGMCC No: 66270. The lactobacillus paracasei strain provided by the invention has good gastrointestinal tract reverse environment resistance and has good survival ability in simulated gastrointestinal fluid; good self-aggregation capability and hyaluronidase inhibition capability are realized. By establishing a degranulation model of RBL-2H3 cells, it is found that the strain can inhibit mast cell degranulation and relieve allergy; by establishing an RAW264.7 cell inflammation model, the strain disclosed by the invention is found to be capable of inhibiting allergic inflammatory reaction; by establishing an OVA (ovalbumin)-induced BALB / c mouse food allergy model, the strain disclosed by the invention is found to be capable of improving the anti-allergy ability of animals and exerting the activity of relieving food allergy.

The application discloses a malve nut polysaccharide skin care cream and a preparation method thereof, and belongs to the technical field of skin care products. According to the mass fraction, the components of the malve nut polysaccharide skin care cream comprise 60-85 parts of water, 3-15 parts of a moisturizing agent, 5-15 parts of an emollient, 6-10 parts of an emulsifier, 0.1-0.5 parts of a preservative and 1-3 parts of a malve nut polysaccharide extract, and a pH regulator is used to adjust the pH of the system to 4.5-6.5. The malve nut polysaccharide skin care cream is prepared by adding the active ingredient malve nut polysaccharide extract to the aqueous skin cream, and the malve nut polysaccharide extract has the characteristics of anti-inflammation, anti-oxidation, anti-allergy, viscoelasticity and film-forming property. By controlling the added amount, the prepared malve nut polysaccharide skin care cream not only retains the refreshing skin feeling and fast absorption characteristics of the aqueous skin cream, but also has the functions of long-acting water locking and barrier repair.

The present invention provides the induction of novel Th1 response, the induction of cytotoxic T cells and anti-cancer / anti-allergic activity techniques. Provided is a combination of a CpG oligonucleotide and an STING agonist. Also provided is a composition which contains an STING agonist, can be used as a type-I adjuvant, and is characterized in that the STING agonist is administered together with a CpG oligonucleotide. Further provided is an anti-cancer agent comprising a CpG oligonucleotide and is characterized in that the CpG oligonucleotide is administered together with an STING agonist. Still further provided is a composition which contains a CpG oligonucleotide and can be used for reducing or eliminating the IgE-inducing activity of an STING agonist.

The application discloses a kind of polystrontium aspartate / potassium and its preparation method and application, belong to daily chemical technical field.The polystrontium aspartate / potassium using poly succinimide can be prepared in the aqueous solution of strontium hydroxide and potassium hydroxide hydrolysis.The preparation process has the characteristics of mild conditions, simple process, low cost, high efficiency and environmental protection.The polystrontium aspartate / potassium provided by the application is used for whitening and anti-allergic toothpaste, has the dual effect of moisturizing and whitening and anti-allergic, compared with adding poly sodium aspartate and potassium chloride, strontium chloride respectively, the use of polystrontium aspartate / potassium eliminates a large number of sodium ions and chloride ions, effectively reduces the ion concentration in formula, reduces formula difficulty.

The invention discloses a method for reducing sensitization of beta-lactoglobulin and a hypoallergenic milk product, the hypoallergenic milk product is prepared through interaction reaction of beta-lactoglobulin and a natural anti-allergic active substance, and the natural anti-allergic active substance is myricetin. The method has the beneficial effects that the allergenicity of beta-Lg can be effectively reduced, a theoretical basis is provided for mechanism research of infant food allergy, and a data support is provided for development of functional infant food; the histamine release rate of KU812 and the expression quantity of IL-4, IL-6 and the like can be remarkably reduced, the food anaphylaxis is regulated and controlled on the gene expression level, and a feasible way is provided for achieving the anti-allergic effect to a certain degree.

Provided is a method for enhancing anti-oxidative ability, anti-bacterial ability, anti-inflammatory ability and / or anti-allergic ability of a textile. The method comprises adding a cannabidiol in an alginate fiber comprising cannabidiol, wherein the textile comprises a yarn comprising the alginate fiber comprising cannabidiol, the alginate fiber comprising cannabidiol comprises the cannabidiol and an alginate, and the cannabidiol disperses in the alginate fiber comprising cannabidiol.

The invention relates to salvia miltiorrhiza and poria cocos combined fermentation liquor and application research thereof in cosmetics, and aims to discuss the reliability of the salvia miltiorrhiza and poria cocos combined fermentation liquor as a functional raw material of the cosmetics. The HYJ bacteria are used for carrying out liquid state fermentation on the salvia miltiorrhiza and poria cocos combination, and the content change of key effective components in the fermentation liquid is researched. A high performance liquid chromatography method is adopted for quantitative analysis, and the anti-oxidation, anti-allergy and whitening effects of the fermentation liquor are evaluated. The research shows that the salvia miltiorrhiza and poria cocos combined fermentation liquor shows higher oxidation resistance than that of an unfermented group in a free radical scavenging experiment of 1, 1-diphenyl-2-trinitrophenylhydrazine and 2, 2-nitrogen-bis (3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt; meanwhile, the inhibition effect of the fermentation liquor on hyaluronidase and tyrosinase is obviously enhanced compared with that of an unfermented group, so that the fermentation liquor has good anti-allergic and whitening effects. The research provides an experimental basis for the application of the salvia miltiorrhiza and poria cocos combined fermentation liquor in cosmetics, and proves the potential of the salvia miltiorrhiza and poria cocos combined fermentation liquor as a functional raw material of the cosmetics.

A nasal allergen blocking agent. Specifically, the present invention relates to a preparation method for an allergen blocking agent loaded with an umbilical cord mesenchymal stem cell culture medium extract. The provided allergen blocking agent is prepared from the following raw materials: lyophilized powders of the umbilical cord mesenchymal stem cell culture medium extract, hydroxypropyl methylcellulose, a honeysuckle extract, and borneol. By means of adding the honeysuckle extract and the umbilical cord mesenchymal stem cell culture medium extract to the allergen blocking agent, under the interaction of various raw materials, capillary permeability can be reduced by means of dilating capillaries, thereby reducing tissue fluid exudation, helping reduce swelling, inhibiting smooth muscle contraction, alleviating the spasticity in the respiratory tract and other parts, and improving related discomfort symptoms. The dry powder mixture is loaded into a nasal spray reagent bottle for use. The anti-allergen blocking agent can not only physically isolate allergens, but also load a variety of stem cell factors contained in the umbilical cord mesenchymal stem cell culture medium extract, thereby eliminating chronic nasal mucosa inflammation, repairing nasal mucosa damage without any toxic and side effects, and effectively resisting the onset of allergic rhinitis.

The utility model discloses a kind of perforated ear ornaments, including main part and perforated part, the main part includes gold main body, the side of gold main body is provided with recess, the perforated part includes titanium needle, one end of the titanium needle is provided with chassis support, the chassis support is provided with electroplating layer, the electroplating layer is gold plating layer, the chassis support is welded in the recess connection.The perforated ear ornament of the utility model uses titanium needle as perforated part, ensures the anti-allergic performance of perforated ear ornament, avoids the crowd of allergic constitution to wear perforated ear ornament and causes allergic reaction.

The present disclosure relates to a novel microorganism, a lysate thereof, a culture broth thereof, and anti-allergy uses thereof, wherein a novel strain according to one aspect, a lysate derived from the strain, a culture broth of the strain, an extract of the culture broth, or a mixture thereof may be advantageously used in prevention, alleviation, or treatment of allergic diseases.

The invention relates to the technical field of antianaphylaxis, in particular to an antianaphylaxis polymer and application of the antianaphylaxis polymer as a skin repairing agent.The antianaphylaxis polymer is composed of chitosan, a tannic acid-ovalbumin compound and amination modified graphene quantum dots; the particle size of the amination modified graphene quantum dots is 5-20 nm, the surface amino density is 3.5-5.0 mmol / g, and the addition amount of the amination modified graphene quantum dots is 0.5-1% of the mass of ovalbumin protein; the mass ratio of the chitosan to the tannic acid-ovalbumin compound is 1: (0.5-0.8); the anti-allergic polymer prepared by the scheme has excellent anti-allergic performance and skin repair effect, all components of the cream prepared by compounding the anti-allergic polymer with specific auxiliary materials are selected from natural materials or materials with good biocompatibility, the preparation process is mild and controllable, no harmful by-product is generated, and the product is mild and non-irritant in use and is suitable for long-term use.

Disclosed are a hot melt adhesive for an infant navel paste, a preparation method therefor, and an infant navel paste comprising same, which relate to the technical field of medical instruments. The hot melt adhesive for the infant navel paste mainly comprises a thermoplastic copolymer, mineral oil, tackifying resin, cellulose, an anti-inflammatory substance, and an antioxidant. The mass ratio of the thermoplastic copolymer to the tackifying resin to the cellulose is (10-20):(20-30):(20-50). It is found by means of long-term test research that the hot melt adhesive obtained from the thermoplastic copolymer, the tackifying resin, and the cellulose at the above mass ratio has good application viscosity and proper stripping force under the condition of 35-40 °C, and the hot melt adhesive can be used as an infant navel paste to achieve the technical effects of good application performance, free pain, and tear susceptibility. Meanwhile, the hot melt adhesive also contains the anti-inflammatory substance, and the used raw materials have no allergic irritation, so that the hot melt adhesive for the infant navel paste of the present application also has good anti-inflammatory and anti-allergic effects.

Massage patch (8) for acupressure, the massage patch comprising a film section (8c) with an adhesive first surface (8d), preferably comprising an anti-allergic adhesive and binder, a magnetizable, in particular rotationally symmetrical, acupressure element (8b) which is arranged adjacent to the first surface, preferably which is materially bonded to the first surface, wherein the acupressure element is formed with stainless steel as the first material.

The present invention provides the use of a composition containing sardine peptides in improving the symptoms of atopic dermatitis. The sardine peptides are a mixture of sardine dipeptides to pentapeptides. The oligopeptides contained in the sardine peptides have high biological activity. These oligopeptides constitute short anti-allergic active peptides that can regulate the function of T cells, especially Th2 cells. These cells play a key role in the allergic reaction of atopic dermatitis and can promote the production of IgE antibodies. Therefore, the short anti-allergic active peptides reduce the production of IgE by inhibiting the activation and proliferation of Th2 cells, thereby improving the symptoms of atopic dermatitis.

The invention relates to an anti-aging and anti-allergic skin external composition containing elaeagnus angustifolia fruit extract and a preparation method of the anti-aging and anti-allergic skin external composition. Specifically, the invention relates to application of the elaeagnus angustifolia fruit extract in preparation of an anti-aging composition for external use on skin and a method for preparing the elaeagnus angustifolia fruit extract. The invention relates to an elaeagnus angustifolia fruit extract which contains the elaeagnus angustifolia fruit extract and has the related effects of promoting skin first-type collagen proliferation and skin fibroblast proliferation, inhibiting first-type metalloproteinase activity, reducing and regulating tumor necrosis factor-alpha and inhibiting expression of allergic medium beta-hexosaminidase in the field of cosmetics. And the composition has an effect of inhibiting an allergic medium or can be used for relieving sensitive skin.

The present invention relates to a novel Lacticaseibacillus rhamnosus HLL-002 strain exhibiting anti-inflammatory and anti-allergic activities and, more specifically, provides: a Lacticaseibacillus rhamnosus HLL-002 strain; a probiotic composition comprising same; a health functional food composition comprising the composition; and a pharmaceutical composition for preventing or treating allergic diseases, comprising the strain.