48 results about "Allergic anti" patented technology

The invention provides kelp fucoidin with low molecular weight and high anti-anaphylaxis as well as a preparation method and application thereof, and belongs to the technical field of food processing. The preparation method comprises the following steps: mixing kelp fucoidin with water to obtain a kelp fucoidin solution; and mixing the kelp fucoidin solution with H2O2 and Vc, reacting, adjusting the pH value, dialyzing and freeze-drying to obtain the kelp fucoidin with low molecular weight and high anti-allergic property. The H2O2-Vc degradation system is innovatively applied to preparation of the low-molecular-weight kelp fucoidin and improvement of the anti-allergic activity of the low-molecular-weight kelp fucoidin. In the degradation process, the chemical composition of the fucoidin is partially changed, but monosaccharide types and functional groups are not influenced. Through multiple ways of cell model and animal model experiments, the degraded laminaria fucoidin is more prominent in anti-allergic activity. Technical support is provided for development of seaweed-derived anti-allergic functional active substances, and high-valued utilization of kelp resources in the fields of functional food and medicines is further promoted.

The application provides an extraction method and application of artemisia fiber, and the artemisia fiber is efficiently prepared by the following steps: mild degradation of lignocellulose structure through microbial pretreatment, and dissolution and regeneration in combination with a green solvent system of N-methyl morpholine-N-oxide solution (hereinafter referred to as "NMMO solution"), so that high-value utilization of artemisia waste stems and stalks is realized. The obtained artemisia fiber can retain part of active ingredients from plants, has certain odor removal, antioxidant and anti-allergic potential in food-grade packaging materials and green wallpaper applications, and overcomes defects such as difficult degradation, easy damp and mildew, and single function of traditional packaging materials and wallpapers.

The present application relates to a kind of compositions with anti-inflammatory and anti-allergic effects and its application, and the preparation raw materials of the composition include boletus, phyllanthus and rose apple.The present application uses steam explosion coupling heating reflux preparation to prepare the composition with boletus, phyllanthus, rose apple as preparation raw material, the method not only significantly improves extraction efficiency and biological activity, compared with traditional extraction technology, also avoids the use of organic reagent, more environmentally friendly and safe.

The invention discloses a real breathable probiotic ultrathin spill-proof breast pad which comprises a breast pad body, the breast pad body is composed of a surface layer located on the skin-friendly side and an absorber compounded on the surface of the outer side of the surface layer, and on a vertical hierarchical structure, the absorbers are arranged from inside to outside. The absorber comprises a wood pulp fiber non-woven fabric layer, a polymer absorbing layer, a dust-free paper layer and a spunbond non-woven fabric water-repellent layer; on the perspective structure of the plane of the skin-friendly side, the breast pad body comprises an absorption area located in the center area of the body and an embossing area located in the peripheral area of the absorption area, the macromolecule absorption layer corresponds to the absorption area, and the portion, on the skin-friendly side, of the embossing area is provided with silica gel attaching points capable of being attached to the skin and inner release paper covering the embossing area. The outer side surface of the spunbond non-woven fabric water-repellent layer is provided with a back adhesive area used for being attached to brassiere underwear, and the back adhesive area is covered with outer release paper. The anti-galactorrhea pad has the advantages of being ultrathin, high in breathability, low in reverse osmosis, high in absorption, bacteriostatic and antiallergic, has a selectable fixed wearing form, and meets diversified wearing requirements.

The present application relates to the technical field of skin care products, and discloses a composition with the effect of soothing sensitive skin, which is composed of the following components in mass percentage: plant extract 10-12%, skin repair factor 2-3%, jasmine hydrolat 10%, humectant 6-7%, and the balance being water. The composition with the effect of soothing sensitive skin has significant soothing effect, which is close to the soothing effect of common hormone ointments on the market. The composition can significantly reduce inflammatory factors, has good anti-inflammatory effect, simultaneously repairs damaged skin, enhances the moisturizing function, and enhances the skin barrier through the moisturizing and repairing effect. The composition has the effect of resisting anaphylaxis by reducing the content of trypsin and inhibiting the allergic reaction of mast cells. Human patch test and fish embryo development toxicity test prove that the composition with the effect of soothing sensitive skin has no skin adverse reactions and no development toxicity, is mild, safe and non-irritating, and is suitable for preparing skin care products for adults and infants.

This invention provides a small molecule inhibitor targeting the FcεRIγ subunit and its application. It discovers that erythrophenol can act as a small molecule inhibitor targeting the FcεRIγ subunit, thereby inhibiting the occurrence of allergic reactions. This invention confirms the direct binding interaction between erythrophenol and the FcεRIγ subunit using SPR and CETSA techniques, revealing that erythrophenol can target and inhibit the FcεRIγ subunit. Furthermore, this invention finds that erythrophenol can significantly inhibit the release of IgE signal-induced β-aminoglycosidase in mast cells, exhibiting a significant ability to inhibit IgE signal-mediated mast cell degranulation and suppress mast cell activation-mediated allergic reactions. This fully demonstrates that erythrophenol, as an inhibitor targeting the FcεRIγ subunit, holds promise as the first inhibitor to induce FcεRIγ subunit degradation in anti-type I allergic diseases, and has broad application prospects for further use in anti-allergy treatment.

The invention belongs to the technical field of food microorganisms, and particularly relates to a lactobacillus paracasei BHP06 with an anti-allergic function. The preservation number of the Lactobacillus paracasei BHP06 is GDMCC (China General Microbiological Culture Collection Center) No: 66270, and the preservation number of the Lactobacillus paracasei BHP06 is CGMCC No: 66270. The lactobacillus paracasei strain provided by the invention has good gastrointestinal tract reverse environment resistance and has good survival ability in simulated gastrointestinal fluid; good self-aggregation capability and hyaluronidase inhibition capability are realized. By establishing a degranulation model of RBL-2H3 cells, it is found that the strain can inhibit mast cell degranulation and relieve allergy; by establishing an RAW264.7 cell inflammation model, the strain disclosed by the invention is found to be capable of inhibiting allergic inflammatory reaction; by establishing an OVA (ovalbumin)-induced BALB / c mouse food allergy model, the strain disclosed by the invention is found to be capable of improving the anti-allergy ability of animals and exerting the activity of relieving food allergy.

The application discloses a malve nut polysaccharide skin care cream and a preparation method thereof, and belongs to the technical field of skin care products. According to the mass fraction, the components of the malve nut polysaccharide skin care cream comprise 60-85 parts of water, 3-15 parts of a moisturizing agent, 5-15 parts of an emollient, 6-10 parts of an emulsifier, 0.1-0.5 parts of a preservative and 1-3 parts of a malve nut polysaccharide extract, and a pH regulator is used to adjust the pH of the system to 4.5-6.5. The malve nut polysaccharide skin care cream is prepared by adding the active ingredient malve nut polysaccharide extract to the aqueous skin cream, and the malve nut polysaccharide extract has the characteristics of anti-inflammation, anti-oxidation, anti-allergy, viscoelasticity and film-forming property. By controlling the added amount, the prepared malve nut polysaccharide skin care cream not only retains the refreshing skin feeling and fast absorption characteristics of the aqueous skin cream, but also has the functions of long-acting water locking and barrier repair.

The application discloses a kind of polystrontium aspartate / potassium and its preparation method and application, belong to daily chemical technical field.The polystrontium aspartate / potassium using poly succinimide can be prepared in the aqueous solution of strontium hydroxide and potassium hydroxide hydrolysis.The preparation process has the characteristics of mild conditions, simple process, low cost, high efficiency and environmental protection.The polystrontium aspartate / potassium provided by the application is used for whitening and anti-allergic toothpaste, has the dual effect of moisturizing and whitening and anti-allergic, compared with adding poly sodium aspartate and potassium chloride, strontium chloride respectively, the use of polystrontium aspartate / potassium eliminates a large number of sodium ions and chloride ions, effectively reduces the ion concentration in formula, reduces formula difficulty.

Provided is a method for enhancing anti-oxidative ability, anti-bacterial ability, anti-inflammatory ability and / or anti-allergic ability of a textile. The method comprises adding a cannabidiol in an alginate fiber comprising cannabidiol, wherein the textile comprises a yarn comprising the alginate fiber comprising cannabidiol, the alginate fiber comprising cannabidiol comprises the cannabidiol and an alginate, and the cannabidiol disperses in the alginate fiber comprising cannabidiol.

The invention relates to salvia miltiorrhiza and poria cocos combined fermentation liquor and application research thereof in cosmetics, and aims to discuss the reliability of the salvia miltiorrhiza and poria cocos combined fermentation liquor as a functional raw material of the cosmetics. The HYJ bacteria are used for carrying out liquid state fermentation on the salvia miltiorrhiza and poria cocos combination, and the content change of key effective components in the fermentation liquid is researched. A high performance liquid chromatography method is adopted for quantitative analysis, and the anti-oxidation, anti-allergy and whitening effects of the fermentation liquor are evaluated. The research shows that the salvia miltiorrhiza and poria cocos combined fermentation liquor shows higher oxidation resistance than that of an unfermented group in a free radical scavenging experiment of 1, 1-diphenyl-2-trinitrophenylhydrazine and 2, 2-nitrogen-bis (3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt; meanwhile, the inhibition effect of the fermentation liquor on hyaluronidase and tyrosinase is obviously enhanced compared with that of an unfermented group, so that the fermentation liquor has good anti-allergic and whitening effects. The research provides an experimental basis for the application of the salvia miltiorrhiza and poria cocos combined fermentation liquor in cosmetics, and proves the potential of the salvia miltiorrhiza and poria cocos combined fermentation liquor as a functional raw material of the cosmetics.

A nasal allergen blocking agent. Specifically, the present invention relates to a preparation method for an allergen blocking agent loaded with an umbilical cord mesenchymal stem cell culture medium extract. The provided allergen blocking agent is prepared from the following raw materials: lyophilized powders of the umbilical cord mesenchymal stem cell culture medium extract, hydroxypropyl methylcellulose, a honeysuckle extract, and borneol. By means of adding the honeysuckle extract and the umbilical cord mesenchymal stem cell culture medium extract to the allergen blocking agent, under the interaction of various raw materials, capillary permeability can be reduced by means of dilating capillaries, thereby reducing tissue fluid exudation, helping reduce swelling, inhibiting smooth muscle contraction, alleviating the spasticity in the respiratory tract and other parts, and improving related discomfort symptoms. The dry powder mixture is loaded into a nasal spray reagent bottle for use. The anti-allergen blocking agent can not only physically isolate allergens, but also load a variety of stem cell factors contained in the umbilical cord mesenchymal stem cell culture medium extract, thereby eliminating chronic nasal mucosa inflammation, repairing nasal mucosa damage without any toxic and side effects, and effectively resisting the onset of allergic rhinitis.

The utility model discloses a kind of perforated ear ornaments, including main part and perforated part, the main part includes gold main body, the side of gold main body is provided with recess, the perforated part includes titanium needle, one end of the titanium needle is provided with chassis support, the chassis support is provided with electroplating layer, the electroplating layer is gold plating layer, the chassis support is welded in the recess connection.The perforated ear ornament of the utility model uses titanium needle as perforated part, ensures the anti-allergic performance of perforated ear ornament, avoids the crowd of allergic constitution to wear perforated ear ornament and causes allergic reaction.

The present disclosure relates to a novel microorganism, a lysate thereof, a culture broth thereof, and anti-allergy uses thereof, wherein a novel strain according to one aspect, a lysate derived from the strain, a culture broth of the strain, an extract of the culture broth, or a mixture thereof may be advantageously used in prevention, alleviation, or treatment of allergic diseases.

The invention relates to the technical field of antianaphylaxis, in particular to an antianaphylaxis polymer and application of the antianaphylaxis polymer as a skin repairing agent.The antianaphylaxis polymer is composed of chitosan, a tannic acid-ovalbumin compound and amination modified graphene quantum dots; the particle size of the amination modified graphene quantum dots is 5-20 nm, the surface amino density is 3.5-5.0 mmol / g, and the addition amount of the amination modified graphene quantum dots is 0.5-1% of the mass of ovalbumin protein; the mass ratio of the chitosan to the tannic acid-ovalbumin compound is 1: (0.5-0.8); the anti-allergic polymer prepared by the scheme has excellent anti-allergic performance and skin repair effect, all components of the cream prepared by compounding the anti-allergic polymer with specific auxiliary materials are selected from natural materials or materials with good biocompatibility, the preparation process is mild and controllable, no harmful by-product is generated, and the product is mild and non-irritant in use and is suitable for long-term use.

Massage patch (8) for acupressure, the massage patch comprising a film section (8c) with an adhesive first surface (8d), preferably comprising an anti-allergic adhesive and binder, a magnetizable, in particular rotationally symmetrical, acupressure element (8b) which is arranged adjacent to the first surface, preferably which is materially bonded to the first surface, wherein the acupressure element is formed with stainless steel as the first material.

The present invention relates to a novel Lacticaseibacillus rhamnosus HLL-002 strain exhibiting anti-inflammatory and anti-allergic activities and, more specifically, provides: a Lacticaseibacillus rhamnosus HLL-002 strain; a probiotic composition comprising same; a health functional food composition comprising the composition; and a pharmaceutical composition for preventing or treating allergic diseases, comprising the strain.

The present application belongs to the technical field of cosmetics, and particularly relates to a bird's nest composition capable of reducing the sensitization of cosmetic ingredients, which is composed of the following components in parts by weight: 30-60 parts of bird's nest acid, 10-30 parts of bird's nest peptide, 10-20 parts of bird's nest extract, and 1-30 parts of hydrolyzed bird's nest. The present application is derived from natural bird's nest and has good moisturizing and anti-allergic effects, and can effectively reduce the allergy caused by irritating substances in cosmetics, and solve the problem of skin sensitization caused by irritating ingredients in cosmetics.

An anti-allergic product containing: at least 0.01% w / w of a plant extract wherein the plant extract is selected from the group consisting of tea leaf extract, melaleuca alternifolia leaf oil and mixtures thereof; an amphiphilic preservative and a glycolipid. The eyelid cleansing composition is configured to alleviate redness, discomfort, and irritation in and around the eyelid.

Provided is a Lactobacillus brevis ATIT-054 producing γ-aminobutyric acid (GABA). Further provided are a dry powder made from the Lactobacillus brevis and a use thereof in preparing a composition for scavenging free radicals, inhibiting angiotensin converting enzyme I, inhibiting α-glucosidase, promoting collagen protein production, and for anti-inflammatory and anti-allergic uses.

To provide a medicine for intestinal disorders, an antiallergic agent, an immunoadjuvant and an agent for improving enteroadherent properties of lactic acid bacteria, which can be taken safely, are available inexpensively, and have high effect of improving enteroadherent properties of lactic acid bacteria.SOLUTION: An agent according to the present invention contains flower extract. The flower is a Lythraceae, Asteraceae, Fabaceae, Rosaceae or Iridaceae flower, preferably, at least one selected from Carthamus tinctorius, Punica granatum, Pueraria plants, Subgen. Cerasus plants, Chrysanthemum plants, Crocus sativus, Prunus persica Batsch and Rosa plants.SELECTED DRAWING: Figure 1

This invention discloses a complex functional protein peptide derived from sea cucumber, its formulation, and its applications, belonging to the field of bioactive peptide technology. The amino acid sequence of the complex functional protein peptide derived from sea cucumber in this invention is at least one of FFGG, FGAF, and FDGF. Using sea cucumber blanching solution as raw material, this invention employs methods such as protease hydrolysis, LC-MS / MS, and bioinformatics to separate and purify three bioactive peptides with antioxidant and anti-allergic effects. Based on the identified peptide sequences, chemical synthesis is performed, and the antioxidant and anti-allergic effects of the synthesized single peptides and complex peptides are measured. These bioactive peptides all exhibit high DPPH scavenging rates, ABTS free radical scavenging rates, and hyaluronic acid inhibition rates. Therefore, these bioactive peptides have significant application prospects in the development of products with antioxidant and anti-allergic effects.

The application discloses a preparation process of effervescent granules of a composition containing phenylephrine hydrochloride, which is prepared by taking phenylephrine hydrochloride as a main active ingredient, and by adding antiallergic agents, expectorants, antitussives, antipyretics, anti-inflammatory agents and combinations thereof. In order to prevent degradation of phenylephrine hydrochloride, the phenylephrine hydrochloride is first wrapped with PEG together with an alkali source, and then mixed with other components to prepare the effervescent granules. The effervescent granules prepared by the method have the advantages of high drug stability, rapid effect, high bioavailability, convenient carrying and low cost, and are suitable for children, the elderly and patients who cannot swallow solid preparations.

The application provides a hot melt adhesive for infant umbilical sticking plaster and a preparation method thereof and an infant umbilical sticking plaster containing the same, and relates to the technical field of medical devices. The hot melt adhesive for infant umbilical sticking plaster is mainly composed of a thermoplastic copolymer, mineral oil, tackifying resin, cellulose, anti-inflammatory substances and antioxidants, wherein the mass ratio of the thermoplastic copolymer, the tackifying resin and the cellulose is 10-20:20-30:20-50. The applicant finds, through long-term experimental research, that the hot melt adhesive obtained from the mass ratio of the thermoplastic copolymer, the tackifying resin and the cellulose has good sticking viscosity and appropriate peeling force under the condition of 35-40 DEG C, and the use of the hot melt adhesive as the infant umbilical sticking plaster can achieve the technical effects of good sticking, painless and easy tearing. Meanwhile, the hot melt adhesive contains anti-inflammatory substances, and all the raw materials used are non-allergic and non-irritating, so that the hot melt adhesive for infant umbilical sticking plaster also has good anti-inflammatory and anti-allergic effects.

This invention discloses a fusion peptide with synergistic anti-allergic effects, an anti-LTB4 monoclonal antibody, and an anti-allergic drug composition thereof. The fusion peptide is composed of peptide A, which inhibits histamine release, and peptide B, which blocks mast cell activation signals, covalently linked by a linker peptide, which can synergistically inhibit mast cell activation. The anti-LTB4 monoclonal antibody can specifically bind to LTB4, blocking its mediated inflammatory response. Combining the fusion peptide, the anti-LTB4 monoclonal antibody, and myricetin, which has antioxidant activity, forms a multi-target drug composition that can synergistically inhibit allergic reactions from multiple aspects, such as inhibiting mast cell degranulation, blocking the action of inflammatory mediators, and clearing oxidative stress products. In vitro cell experiments and OVA-induced allergic asthma mouse models have demonstrated that the anti-allergic effect of this composition is significantly better than that of a single component, and it has no obvious toxicity, providing a new candidate drug for the efficient treatment of allergic diseases.

The invention discloses a composition for moisturizing and protecting skin and a preparation method of the composition. Through the structure, the composition comprises 3%-8% of the moisturizing component, 2%-8% of the emulsifier and the stabilizer, 0.5%-2% of the pH regulator, 0.8%-3.5% of the preservative, 2%-5% of the ultraviolet light absorber, 4%-16% of the physical sun-screening agent, 0.1%-0.5% of the anti-allergic agent, 0.5%-2% of the cutin conditioner, 0.1%-1% of the antioxidant and the balance of the solvent. The skin can be quickly moistened, a long-time moisturizing effect can be provided, and the skin can be continuously kept moist; the skin care cream also has various skin care effects of resisting oxidation, blocking sun, resisting allergy, conditioning cutin and the like, and can provide all-around care for the skin.

A method for preparing an albumin peptide that enhances immunity and combats allergies, relating to the field of small molecule active peptides, is disclosed. The method includes: dissolving egg white powder in pure water, adjusting the pH, and allowing the mixture to settle and precipitate ovalbumin; dissolving the ovalbumin precipitate in pure water, adjusting the pH and temperature, and then adding a complex protease for enzymatic hydrolysis; after hydrolysis, heating the solution to inactivate the enzyme; centrifuging the enzyme-inactivated solution and desalting the supernatant; separating the desalted solution using a membrane device and collecting the permeate; concentrating and drying the permeate to obtain the small molecule albumin peptide. This invention provides an albumin peptide that enhances immunity and combats allergies, its preparation method, and the anti-allergic active peptide Ala-Leu-Ala-Met, which not only eliminates the allergenicity of ovalbumin but also possesses anti-allergic activity, showing promising application prospects and significant implications for the further application of ovalbumin-related products in the food and pharmaceutical fields.

The invention relates to the technical field of microorganisms, and provides a lactobacillus rhamnosus B12 with the effects of resisting allergy, enhancing immunity, conditioning intestinal flora and fermenting and application of the lactobacillus rhamnosus B12. The preservation number of the strain is CGMCC No.34366. The strain is wide in carbon source growth adaptability, has good short-chain fatty acid secretion level, biofilm forming ability, DPPH free radical scavenging ability and gastric juice and pancreatic juice tolerance, can promote expression of various immune factors of zebra fish, reduce the immune globulin IgE level, can optimize the intestinal flora structure, and can improve the immunity of the zebra fish. A good bacteriostatic effect is achieved on harmful pathogenic bacteria; in addition, various plant bases can be fermented, the SOD activity, the substrate chromaticity and the flavor quality of a fermented product are improved, and the content of red wolfberry protein and total amino acid is remarkably increased. The strain can provide a new probiotic source for the development of anti-allergic products, immunity enhancing products, intestinal flora conditioning products, antioxidant products, antibacterial products and fermented products.

The invention relates to the technical field of deep processing of antarctic krill, in particular to antarctic krill peptide with anti-allergic activity and hyaluronidase inhibitory activity as well as a preparation method and a functional product of the antarctic krill peptide. The preparation method comprises the following steps: mixing Antarctic krill powder with absolute ethyl alcohol and normal hexane, extracting and removing krill oil to obtain powder residues; mixing the powder residues with water, firstly adjusting the pH value and the temperature, carrying out primary hydrolysis by using alkaline protease, then adjusting the pH value, and carrying out secondary hydrolysis by using flavourzyme; and defluorinating, decoloring and carrying out solid-liquid separation in sequence after the second hydrolysate is subjected to enzyme deactivation, so as to obtain filtrate, and drying the filtrate, so that the euphausia superba peptide is obtained. The euphausia superba peptide prepared by the method contains various specific active peptide fragments including PFSLR and TSGFTL, can effectively inhibit the activity of hyaluronidase, and can play an anti-allergic role by regulating and controlling the expression of allergy-related genes, reducing the release of allergy media and the like.