87 results about "Lactobacillus gasseri" patented technology

The invention relates to the technical field of probiotics, in particular to a combined fungicide for improving Alzheimer's disease and application of the combined fungicide. The combined microbial agent is prepared from lactobacillus gasseri LFLG-245 and inactivated Ackermania muciniphila AKKLF (Ackermania muciniphila AKKLF); the lactobacillus gasseri LFLG-245 is preserved in the China General Microbiological Culture Collection Center on March 24, 2025, and the preservation number of the lactobacillus gasseri LFLG-245 is CGMCC (China General Microbiological Culture Collection Center) No.33952. The lactobacillus gasseri LFLG-245 has the advantages that the lactobacillus gasseri LFLG-245 is preserved in the China General Microbiological Culture Collection Center; the Akkermansia muciniphila AKKLF is preserved in the China General Microbiological Culture Collection Center on March 24, 2025, and the preservation number of the Akkermansia muciniphila AKKLF is CGMCC (China General Microbiological Culture Collection Center) No.33955. The Akkermansia muciniphila AKKLF disclosed by the invention has the advantages that the Akkermansia muciniphila AKKLF can be applied to the field of biological The combined microbial agent provided by the invention can improve the Alzheimer's disease.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to shea butter fermentation liquor as well as a preparation method and application thereof. Lactobacillus plantarum, lactobacillus fermentum and lactobacillus gasseri in a specific proportion are adopted to construct a composite fermentation system, acid-resistant aspergillus niger lipase is combined, and shea butter is treated through a one-step fermentation process. By means of the synergistic effect of the three strains and the synergistic effect of the enzyme and the strains, efficient fermentation can be achieved, the content of active ingredients such as polysaccharide, amino acid and polypeptide in fermentation liquor is remarkably increased, meanwhile, the technological process is simple and stable, and the infectious microbe pollution risk is avoided. According to the fermentation liquor prepared by the process, on the basis of enhancing the original moisturizing and soothing effects of the shea butter, the problems of greasy skin feeling and poor permeation and absorption of the shea butter are effectively solved, the shea butter is further endowed with new functions of repairing skin barriers and balancing skin micro-ecology, and the application values of the shea butter and the fermentation liquor are greatly improved.

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The invention discloses a scalp care solution with the effects of controlling oil, relieving, inhibiting bacteria and adjusting scalp micro-ecology and a preparation method and application thereof.The preparation method of the scalp care solution comprises the following steps that a fermentation substrate is inoculated with saccharomycetes, primary fermentation culture is conducted for 24-72 h, then secondary fermentation culture is conducted through Lactobacillus gasseri, and the scalp care solution is obtained; wherein the fermentation substrate comprises rice, barley seeds and water; wherein the saccharomycetes comprise Saccharomyces cerevisiae (Saccharomyces cerevisiae) and Saccharomyces fibulligera (Saccharomyces fibulligera), and the saccharomycetes comprise Saccharomyces cerevisiae (Saccharomyces fibulligera) and Saccharomyces fibulligera (Saccharomyces fibulligera). The rice and the barley seeds are fermented in a microbial fermentation mode, the bioavailability of the rice and the barley seeds is improved, the content of active ingredients in the fermentation liquor prepared through the fermentation technology is increased, the fermentation liquor has the ideal effects of controlling oil, resisting inflammation, inhibiting bacteria, adjusting scalp micro-ecology and the like, the preparation technology is simple, and the method is suitable for industrial production. The fermentation conditions are mild, no organic solvent is used, and safety is achieved.

The invention discloses a preparation method and application of white tea fermentation liquor with oil control and acne removal effects, lactobacillus plantarum and lactobacillus gasseri are adopted to ferment white tea, other organic reagents do not need to be added, conditions are mild in the fermentation process, the structure of active ingredients of the white tea is not damaged, and the natural activity of the white tea is kept. The production cost is saved, the stability of the product quality is fully guaranteed, chemical components such as essence are not added into the fermentation primary pulp, and the safety to a human body is improved; the white tea can be directly used as a skin care product, and the white tea fermentation liquor is rich in polyphenols, amino acids and the like, and has a synergistic effect with some fermentation product probiotics in the fermentation liquor, so that a stronger effect is shown.

The invention discloses a lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 for transforming curcumin to produce tetrahydrocurcumin to relieve nervous anxiety, and belongs to the technical field of microorganisms. The lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 screened by the invention has the capability of converting curcumin, and can utilize curcumin and generate tetrahydrocurcumin. The invention further provides a synbiotic preparation prepared from the lactobacillus gasseri CCFM1481 and curcumin, the synbiotic preparation can be used as an anti-fatigue functional medicine, the individual behavioral memory level can be improved, the imbalance of body neurotransmitters (DA, 5-HT and NE) can be slowed down, the expression of body neuroprotection related genes (BDNF, TrkB, DRD1 and TH) can be improved, and the synbiotic preparation has a huge application prospect.

This invention relates to the field of probiotic technology, specifically to a combination probiotic agent for improving Alzheimer's disease and its application. The combination probiotic agent includes *Lactobacillus gasseri* LFLG-245 and inactivated *Ackermania maughanii* AKKLF; *Lactobacillus gasseri* (… Lactobacillus gasseri LFLG-245 was deposited on March 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 33952. (Ackermania pseudomallei) Akkermansia muciniphila AKKLF was deposited on March 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 33955. The combined bacterial agent provided by this invention can improve Alzheimer's disease.

The invention discloses a broiler chicken staged combined feed additive, a using method and application, and belongs to the technical field of poultry breeding, the broiler chicken staged combined feed additive comprises a first-stage additive and a second-stage additive; the first-stage additive comprises a bacillus amyloliquefaciens TL preparation, and the second-stage additive comprises a lactobacillus gasseri preparation. Through combined application of the two strains, expression of fat synthesis related genes is promoted, host lipid metabolism is regulated and controlled, the growth performance of the broiler chickens can be remarkably improved, and the method has great significance in improving the breeding efficiency of the broiler chickens.

To provide a novel technology for preventing muscle atrophy by directly promoting muscle synthesis or inhibiting muscle breakdown without physical activity.SOLUTION: Provided is a muscle atrophy prevention agent containing, as an active ingredient, lactic acid bacteria with muscle synthesis-promoting effects and / or muscle breakdown-inhibiting effects, a processed product of the lactic acid bacteria, or an extract thereof, the lactic acid bacteria with muscle synthesis-promoting effects being Lactobacillus gasseri or the like, the lactic acid bacteria with muscle breakdown-inhibiting effects being Lactobacillus reuteri or the like.SELECTED DRAWING: Figure 1

The present application belongs to the field of microbial fermentation and microbial food technology, and particularly relates to a fermentation culture additive of Lactobacillus gasseri JM1 and use thereof. The fermentation culture additive is selected from at least two of polysaccharides of Irpex lacteus, Hericium erinaceus and Inonotus obliquus, or inactivated products of fermentation products of Lactobacillus gasseri JM1. The fermentation culture additive can promote the growth and proliferation of the strain when Lactobacillus gasseri JM1 is fermented. The present application also provides a beverage, and the preparation raw materials include milk powder, polysaccharide products and inactivated Lactobacillus gasseri JM1 blended fermentation products. The polysaccharides in the polysaccharide products are selected from at least two of polysaccharides of Irpex lacteus, Hericium erinaceus and Inonotus obliquus. The inactivated Lactobacillus gasseri JM1 blended fermentation products are added in the fermentation stage of Lactobacillus gasseri JM1, and the polysaccharide products are further added after beverage ingredients are prepared, which is beneficial to improve the viable count and physical stability of the beverage.

The application discloses a preparation method and application of a composite strain of a sugar-controlling probiotic, and belongs to the technical field of microorganisms. The method comprises the steps of strain stock solution preparation, anaerobic culture, pH value determination and regulation, and composite strain proportioning. Through a dynamic shunting mechanism with pH value 4.3 as a threshold, the culture solution lower than the value is subjected to re-acidification treatment, and the culture solution higher than the value is subjected to differential dilution and coating operation. Finally, Lactobacillus gasseri, Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Bifidobacterium breve, Bifidobacterium lactis and Bifidobacterium longum are mixed at a preset ratio, and a sustained-release agent is added for storage. The method can significantly improve the screening efficiency of target probiotics, the stability of the composite preparation and the blood glucose regulation effect, and can be widely applied to the development of sugar-controlling probiotic products.

The invention discloses application of lactobacillus gasseri LS03 in preparation of fat-reducing and weight-losing products, and belongs to the technical field of microorganisms. The lactobacillus gasseri LS03 disclosed by the invention can remarkably promote fat metabolism in a zebra fish body in vivo, can remarkably reduce the content of triglyceride and total cholesterol in a hyperlipidemia zebra fish body, has the potential of being applied to losing weight and regulating the blood fat level, and can be used for preventing and treating hyperlipidemia. The lactobacillus gasseri LS03 provides theoretical reference and guidance basis for developing probiotic preparations for treating or preventing obesity and hyperlipidemia by utilizing the lactobacillus gasseri LS03.

The invention discloses recombinant plant lactobacillus for overexpressing stress protein genes and application of the recombinant plant lactobacillus. Belongs to the technical field of bioengineering. The invention aims to improve the cold-resistant growth capability of the plant lactobacillus and increase the capability of producing lactic acid and degrading nitrite. The invention provides a recombinant lactobacillus plantarum, which is characterized in that the lactobacillus plantarum is used as an original strain, and a nucleic acid molecule as shown in SEQ ID NO.1 is overexpressed. The lactobacillus plantarum is used for improving the cold-resistant growth capability of the lactobacillus plantarum and increasing the capability of producing lactic acid and degrading nitrite.

The invention discloses lactobacillus gasseri CCFM1481 for converting curcumin to produce tetrahydrocurcumin and enhance an anti-fatigue effect, and belongs to the technical field of microorganisms. The lactobacillus gasseri CCFM1481 obtained through screening has the capacity of converting curcumin, curcumin can be utilized, tetrahydrocurcumin can be generated, and the conversion rate is 89.83%. The invention further provides a synbiotic preparation prepared from the lactobacillus gasseri CCFM1481 and curcumin, and the synbiotic preparation can be used as an anti-fatigue functional medicine and has a good application prospect and an industrialization foundation.

This invention relates to the field of gene detection technology, specifically to a primer set and its application, and a training method for a bacterial vaginosis diagnostic model. The primer set, used for diagnosing bacterial vaginosis, includes specific primers for specifically amplifying target regions of the following pathogens: *Atopobacterium vaginalis*, *Gardnerella vaginalis*, *Cyclophorus 1*, *Cyclophorus 2*, *Bacterial Vaginosis-Associated Bacteria 2*, *Animal Curvularia clarithii*, *Animal Curvularia emblica*, *Prevotella 2*, *Lactobacillus curvularia*, *Lactobacillus indolentus*, *Lactobacillus gasseri*, and *Lactobacillus janniae*. This invention also provides the application of this primer set and a training method for a bacterial vaginosis diagnostic model. Using this primer set, high-throughput sequencing can be performed on test samples, simultaneously detecting 12 target pathogens, and further constructing a bacterial vaginosis diagnostic model, which can be used for the clinical diagnosis of bacterial vaginosis with good specificity and sensitivity.

The present application relates to the technical field of probiotics, and particularly relates to a probiotic capable of regulating host intestinal cysteine metabolism and application. Lactobacillus gasseri The probiotic is Lactobacillus gasseri BKR-017, which is classified and named as Lactobacillus gasseri and has been preserved in the China General Microbiological Culture Collection Center on September 26, 2025, the address of the preservation unit is No. 1, Xili, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No: 36098. The present application provides a new precise intervention strategy targeting intestinal Cys metabolism. The Lactobacillus gasseri BKR-017 strain has the advantages of clear mechanism, high safety and significant effect, and provides a safe, effective and feasible new scheme for the auxiliary treatment and prevention of obesity and related metabolic diseases.

This invention provides *Lactobacillus gasseri* and its application in the preparation of phytoestrogens, relating to the field of biofermentation technology. The *Lactobacillus gasseri* is *Lactobacillus gasseri* (…). Lactobacillus gasseri The strain, KMHD3-7519, registered with the China General Microbiological Culture Collection Center (CGMCC) under number CGMCC No. 32351, can increase the content of phytoestrogens in plant extracts. It promotes the conversion of daidzein to daidzein in plant extracts and simultaneously converts daidzein partially to equol, thus increasing the total amount of phytoestrogens in the extract. This invention provides a probiotic capable of simultaneously promoting the conversion of two phytoestrogens, which can be used to produce daidzein, or equol, or simultaneously increase both daidzein and equol, with broad application prospects.

This invention discloses a staged combined feed additive for broilers, its application method, and its application, belonging to the field of poultry farming technology. The invention discloses a staged combined feed additive for broilers, comprising a stage one additive and a stage two additive; the stage one additive includes a Bacillus amyloliquefaciens TL preparation, and the stage two additive includes a Lactobacillus gasseri preparation. This invention, through the combined application of these two strains, promotes the expression of genes related to lipid synthesis and regulates host lipid metabolism, significantly improving broiler growth performance and playing a vital role in enhancing broiler farming efficiency.

The invention belongs to the technical field of microbial fermentation, and particularly relates to lactobacillus gasseri KB24 and application thereof in preparation of cattle spleen peptide for improving spleen deficiency. The preparation method comprises the following steps: (1) pretreatment: removing envelopes of the cattle spleen, crushing, and homogenizing to prepare cattle spleen slurry; (2) enzymolysis treatment: adding a compound enzyme into the cattle spleen slurry for enzymolysis, and sterilizing after enzymolysis to obtain an enzymatic hydrolysate; (3) performing fermentation treatment: inoculating lactobacillus gasseri KB24 into the enzymatic hydrolysate, and performing fermentation to obtain fermentation liquor; and (4) carrying out solid-liquid separation, filtration, ultrafiltration membrane separation and freeze drying on the fermentation liquor to obtain the cattle spleen peptide. The cattle spleen peptide prepared by the method can improve the spleen deficiency symptom from the aspects of weight, holding power, exhaustive swimming time, gastrointestinal digestive function, energy substance metabolism and the like, and can be applied to products for improving spleen deficiency.

The invention discloses lactobacillus gasseri BSJM25L011, lactobacillus gasseri extracellular protein with an oil control effect as well as a preparation method and application of the lactobacillus gasseri extracellular protein. The lactobacillus gasseri has the taxonomic name of Lactobacillus gasseri, is preserved in the China General Microbiological Culture Collection Center on June 16, 2025, has the preservation number of CGMCC No.34898, has the preservation address of No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and has the postcode of 100101, and the lactobacillus gasseri extracellular protein with the oil control effect is obtained by fermenting and culturing the lactobacillus gasseri strain BSJM25L011. The lactobacillus gasseri BSJM25L011 can generate a novel, mild and efficient natural biological oil control active component, and the lactobacillus gasseri extracellular protein disclosed by the invention has an excellent oil control effect, can remarkably regulate skin sebum secretion, can be widely applied to the field of oil control skin external preparations, expands the application field of the lactobacillus gasseri, and has a good application prospect. And the use safety is high.

This invention relates to the fields of microbiology and biomedicine, and particularly to a strain of *Lactobacillus brittlemi* SYSU-32 and its application in tumor treatment. This invention cultured and isolated a strain of *Lactobacillus brittlemi* (SYSU-32). Limosilactobacillus pontis SYSU-32 was deposited on September 15, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 35919. This strain can increase CD8+ in the tumor microenvironment. + Infiltration of T cells and cytotoxic T cells inhibits the progression of colorectal cancer. Furthermore, the combination of *Lactobacillus bridgedii* SYSU-32 with the chemotherapy drug oxaliplatin enhances the pro-apoptotic effect of oxaliplatin, further inhibiting tumor progression and metastasis.

The application provides a lactobacillus gasseri strain A21120 with antioxidant, anti-inflammatory and antitumor functions, and a probiotic agent and application thereof, and belongs to the technical field of functional microorganisms. The strain A21120 is obtained by screening from intestinal feces of a centenarian healthy old person, and is identified by morphology and molecules and belongs to lactobacillus gasseri. The strain has good resistance to gastrointestinal fluid and bovine choline capacity, and has the potential to colonize the intestinal tract. The lactobacillus gasseri strain A21120 provided by the application has bacteriostatic, anti-inflammatory, antioxidant and antitumor activities, and provides a new way for the treatment of clinical related diseases, the development of drugs and the preparation of in vitro preparations or daily necessities.

The application discloses an antibacterial and itch-relieving lotion and application thereof, and belongs to the technical field of biology. The antibacterial and itch-relieving lotion contains an antibacterial and itch-relieving composition, and the composition comprises the following components: nano gold, celery extract and multi-strain co-cultured extract. The strains used in the multi-strain co-cultured extract are Lactobacillus gasseri, Bifidobacterium and yeast. The antibacterial and itch-relieving lotion has good antibacterial effect and is mild and non-irritating due to the synergistic effect among the components of the nano gold, the celery extract and the multi-strain co-cultured extract.

A system for producing a Lactobacillus gasseri SG121 strain composition having a multi-layered protective layer for maintaining memory and learning abilities is provided. The device includes a strain culturing section (91) including a culturing unit (911) used to obtain a Lactobacillus gasseri SG121 culture and a control unit (912) connected to the culturing unit by wire or wirelessly and used to control the culture environment of the culturing unit, a core preparation unit (921) used to prepare the Lactobacillus gasseri SG121 culture from the culturing unit into cores, and an encapsulation processing section (92) installed after the strain culturing section, including an encapsulation unit (922) installed after the core preparation unit and used to receive the cores and perform an encapsulation process thereon. The encapsulation processing section further includes a processing unit (923) installed after the encapsulation unit and used to process the cores that have undergone the encapsulation process into a predetermined dosage form. The composition comprises a core and a multilayer encapsulation structure, of which the multilayer encapsulation structure has five types of functional layer structures, which are layered in sequence on the surface of the core, thereby effectively maintaining the active ingredient's activity of reducing the expression of Aβ42 in the intestinal tract or brain and its activity of regulating the composition of the intestinal flora, thereby achieving the effect of preventing or ameliorating Alzheimer's disease.

The invention belongs to the technical field of plant extraction, and particularly relates to a preparation method of sophora flower bud powder containing quercetin and quercetin glucoside and application of the sophora flower bud powder in preparation of respiratory tract health preparations. The preparation method comprises the following steps: (1) crushing sophora flower buds to obtain sophora flower bud powder, (2) mixing the sophora flower bud powder with water, carrying out heating treatment, then cooling, and carrying out microwave treatment to obtain a pretreated sophora flower bud product; (3) adding a compound enzyme into the pretreated sophora flower bud product, wherein the compound enzyme comprises alpha-amylase, cellulase and hemicellulase; carrying out enzymolysis, and after the enzymolysis is finished, carrying out enzyme deactivation to obtain an enzymolysis product; and (4) adding compound bacteria into the enzymolysis product, carrying out anaerobic fermentation, sterilizing after fermentation, and carrying out spray drying to obtain the pagodatree flower bud powder. According to the preparation method disclosed by the invention, high contents of quercetin and quercetin glucoside in the sophora flower bud powder can be simultaneously kept, and the sophora flower bud powder is good in anti-inflammatory effect.

This invention provides a probiotic composition of Lab4 and Lactobacillus gasseri CUL09 and its application in reducing the risk of vaginal infections, belonging to the field of microbial application technology. Containing the Lab4 probiotic group and the novel strain Lactobacillus gasseri CUL09, this probiotic composition achieves vaginal flora reconstruction via oral administration, effectively improving vaginal pH, eliminating odor, and increasing lactobacillus colonization. This invention also relates to the combination of the probiotic composition with vitamin B6, cranberry extract, and conventional carriers, which can be used in the preparation of foods, dietary supplements, or pharmaceuticals for the prevention and / or treatment of vaginal and urethral microecological imbalances, vaginitis, vaginal candidiasis, and urethral infections. Furthermore, this invention, through the combination of Lab4 and Lactobacillus gasseri CUL09, achieves the inhibition of harmful vaginal bacteria, reconstruction of the vaginal flora to reduce the risk of vaginal infections, and can also prevent and treat urethral infections.

The invention relates to the technical field of microorganisms, in particular to lactobacillus mucilaginosus for inhibiting multiple female vaginal pathogenic bacteria and application of the lactobacillus mucilaginosus. According to the present invention, the fermentation lactobacillus mucus VL9 is separated from the female genital tract at the healthy childbearing age, and the preservation number of the fermentation lactobacillus mucus VL9 is CGMCC No.36415; the strain has good human body compatibility and environmental adaptability, can effectively maintain the acidic environment of the vagina, and has an efficient bacteriostatic effect on pathogenic bacteria in a female urogenital system. The in-vitro culture condition of the fermented lactobacillus mucus VL9 is simple, the cost of the culture medium is low, the method is suitable for a conventional production system, and large-scale preparation can be realized on the premise that the cost is not obviously increased.

Disclosed are a yoghurt for regulating intestinal tract, preparation method therefor, and use thereof, where the yogurt is prepared from raw materials comprising the following parts by weight: 90-97 parts of raw milk, Lactobacillus gasseri of (0.7-5)×108 CFU / 100 g raw milk, Streptococcus thermophilus of (0.1-9)×1010 CFU / 100 g raw milk, Lactobacillus bulgaricus of (0.1-9)×1010 CFU / 100 g raw milk, Lactobacillus acidophilus of (0.5-7)×108 CFU / 100 g raw milk, Lactobacillus plantarum of (0.5-7)×108 CFU / 100 g raw milk, Lactobacillus paracasei of (0.1-9)×107 CFU / 100 g raw milk, and other probiotics, and prebiotics such as inulin. The yogurt may regulate the balance of intestinal flora and prevent constipation and gestational diabetes in overweight and / or obese pregnant women during the gestation period.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to traditional Chinese medicine aromatherapy for relieving anxiety and a preparation method thereof. According to the traditional Chinese medicine fermented composition, radix bupleuri, radix paeoniae alba, fructus gardeniae, moutan bark, albizia flowers, fructus lycii, spina date seeds, poria cocos, rhizoma nardostachyos, licorice roots and Chinese dates serve as raw materials and are mixed with deionized water, sterilization is conducted, then lactococcus gasseri, lactobacillus gasseri and lactobacillus pentosus are inoculated, anaerobic fermentation is conducted, and the prepared traditional Chinese medicine fermented composition has the excellent anxiety relieving effect; the traditional Chinese medicine fermentation composition can be applied to preparation of traditional Chinese medicine aromatherapy with the anxiety relieving effect, and the problems that an existing product is poor in anxiety relieving effect and the like can be solved. The preparation method of the traditional Chinese medicine aromatherapy product is easy to operate and suitable for actual industrial production, and has good clinical application value.