163 results about "Lactobacillus gasseri" patented technology

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention relates to a probiotic agent for regulating an intestinal environment and an application of the probiotic agent. The bacterial strains in the probiotic agent for regulating the intestinal environment comprise a Bifidobacterium animalis subsp. Lactis C-1 bacterial strain and a Lactobacillus gasseri CKCC 1913 bacterial strain, and the bacterial strains in the probiotic agent for regulating the intestinal environment comprise a lactobacillus plantarum subsp. Lactis C-1 bacterial strain and a lactobacillus gasseri CKCC 1913 bacterial strain, a lactobacillus plantarum subsp. Lactis CKCC 1913 bacterial strain, a lactobacillus plantarum subsp. Lactis CKCC 1913 bacterial strain and a lactobacillus plantarum subsp. Lactis CKCC 1913 bacterial strain. A synergistic interaction relationship exists between the two bacteria, so that the intestinal micro-ecological environment can be regulated, the intestinal injury can be relieved and the intestinal barrier function can be improved by reducing the level of inflammatory factors, balancing the content of gastrointestinal regulatory peptides, promoting intestinal peristalsis and other action mechanisms. Therefore, the probiotic agent is suitable for preparing a preparation with the efficacy of preventing, improving or treating constipation and other inflammatory diseases.

The invention discloses lactobacillus gasseri capable of improving expression of host antibacterial peptide Cathelicidin and secretory immunoglobulin sIgA and enhancing infection resistance by oral administration and external application and a metagen thereof, and belongs to the technical field of microorganisms. The lactobacillus gasseri disclosed by the invention can be used for promoting the generation of a vaginal epithelial cell antibacterial peptide Cathelicidin; the shedding of vaginal epithelial cells is reduced, the fungal load is reduced, and the generation of vaginal tissue antibacterial peptide CRAMP is improved; the pIgR and immune globulin content of the vaginal tissue is increased; the invention also finds that the lactobacillus gasseri for external use can regulate and control TLR2 (Toll-Like Receptor 2), and further has a good balancing effect on body immunity. Therefore, the lactobacillus gasseri has a huge application prospect in a product for improving the pathogenic bacterium infection resistance of a host, enhancing the self-defense capability and inhibiting the vagina inflammation.

The invention relates to the technical field of probiotics, in particular to a combined fungicide for improving Alzheimer's disease and application of the combined fungicide. The combined microbial agent is prepared from lactobacillus gasseri LFLG-245 and inactivated Ackermania muciniphila AKKLF (Ackermania muciniphila AKKLF); the lactobacillus gasseri LFLG-245 is preserved in the China General Microbiological Culture Collection Center on March 24, 2025, and the preservation number of the lactobacillus gasseri LFLG-245 is CGMCC (China General Microbiological Culture Collection Center) No.33952. The lactobacillus gasseri LFLG-245 has the advantages that the lactobacillus gasseri LFLG-245 is preserved in the China General Microbiological Culture Collection Center; the Akkermansia muciniphila AKKLF is preserved in the China General Microbiological Culture Collection Center on March 24, 2025, and the preservation number of the Akkermansia muciniphila AKKLF is CGMCC (China General Microbiological Culture Collection Center) No.33955. The Akkermansia muciniphila AKKLF disclosed by the invention has the advantages that the Akkermansia muciniphila AKKLF can be applied to the field of biological The combined microbial agent provided by the invention can improve the Alzheimer's disease.

The invention provides lactobacillus gasseri which is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on February 7, 2023, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.26504. The lactobacillus gasseri has the advantages that the lactobacillus gasseri can be used for preparing the lactobacillus gasseri; the lactobacillus gasseri has a relatively strong inhibition effect on pathogenic bacteria such as Gardneria vaginalis, Escherichia coli, staphylococcus aureus and two-way Pleuromycosis, and also has a certain inhibition effect on CA, so that the lactobacillus gasseri has the effects of killing pathogenic bacteria, improving the host mucosal immunity and resisting infection, and has a good application prospect in the field of animal husbandry, animal husbandry, animal husbandry, animal husbandry, animal husbandry, animal husbandry, animal husbandry and animal husbandry. Meanwhile, growth and reproduction of harmful bacteria can be inhibited, vaginal infection is prevented, and inflammation is treated.

The invention discloses a double-bacterium fermented low-beany-flavor functional soybean milk formula and a preparation method thereof. According to the formula, the adding amount of cane sugar is 4.2% of the mass of a mixed solution. The inoculation amount of the compound lactic acid bacteria is 2.8% of the mass of the fermentation substrate. Wherein the compound lactic acid bacteria comprise lactobacillus plantarum JM065 and lactobacillus gasseri JM1, and the ratio of the lactobacillus plantarum JM065 to the lactobacillus gasseri JM1 is 1: 2 according to the mass ratio of the lactobacillus plantarum JM065 to the lactobacillus gasseri JM1. The preparation method comprises the following steps: selecting, blanching, soaking, grinding, homogenizing, sterilizing, cooling, fermenting and after-ripening. The fermentation temperature is 42 DEG C, and the fermentation time is 8 hours. The soybean milk prepared by fermenting the lactobacillus plantarum JM065 and the lactobacillus gasseri JM1 has the characteristics of oxidation resistance, mellow taste, smooth mouthfeel and pure, fragrant and long aftertaste.

The invention belongs to the technical field of probiotic products, and particularly relates to lactobacillus rhamnosus JM039 as well as a composition and application thereof. The preservation number of the lactobacillus rhamnosus JM039 is GDMCC No: 64409. The lactobacillus rhamnosus JM039 is a lactobacillus rhamnosus strain. The composition is prepared from lactobacillus reuteri J1, lactobacillus gasseri JM1, lactobacillus paracasei JY062, lactobacillus paracasei with the preservation number of GDMCC.No.62990, lactobacillus plantarum JY039 and lactobacillus rhamnosus JM039, and is prepared from lactobacillus reuteri J1, lactobacillus gasseri JM1, lactobacillus paracasei JY062, lactobacillus paracasei with the preservation number of GDMCC.No.62990, lactobacillus plantarum The combined bacteria of the six probiotics can improve the levels of anti-inflammatory factors and intestinal epithelium tight junction proteins and reduce the levels of proinflammatory factors and claudin-2 mRNA, so that the intestinal microenvironment homeostasis and intestinal barrier integrity are maintained through double regulation of inflammatory factors and tight junction proteins, and necrotizing enterocolitis can be relieved.

The invention belongs to the technical field of cosmetic raw materials, and particularly relates to shea butter fermentation liquor as well as a preparation method and application thereof. Lactobacillus plantarum, lactobacillus fermentum and lactobacillus gasseri in a specific proportion are adopted to construct a composite fermentation system, acid-resistant aspergillus niger lipase is combined, and shea butter is treated through a one-step fermentation process. By means of the synergistic effect of the three strains and the synergistic effect of the enzyme and the strains, efficient fermentation can be achieved, the content of active ingredients such as polysaccharide, amino acid and polypeptide in fermentation liquor is remarkably increased, meanwhile, the technological process is simple and stable, and the infectious microbe pollution risk is avoided. According to the fermentation liquor prepared by the process, on the basis of enhancing the original moisturizing and soothing effects of the shea butter, the problems of greasy skin feeling and poor permeation and absorption of the shea butter are effectively solved, the shea butter is further endowed with new functions of repairing skin barriers and balancing skin micro-ecology, and the application values of the shea butter and the fermentation liquor are greatly improved.

The present invention relates to a composition comprising Lactobacillus gasseri for preventing and treating sarcopenia and, particularly, to: a composition comprising Lactobacillus gasseri BNR17 for preventing, treating or alleviating sarcopenia, a decrease in muscle mass and muscle function, and a decrease in muscular strength and muscular endurance, which are induced by causes such as stress, obesity, aging, drugs, tumors, and the like.

Provided is a composition for controlling uptake of microparticles into a body, the composition containing a lactic acid bacterium. The lactic acid bacterium is preferably any one selected from bacteria belonging to the genus Lactobacillus and bacteria belonging to the genus Streptococcus. For example, the lactic acid bacterium is a bacterium belonging to Lactobacillus delbrueckii, Lactobacillus paracasei, Lactobacillus gasseri, or Streptococcus thermophilus.

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The invention relates to the technical field of functional food production through microbial fermentation, in particular to a herba epimedii enzymolysis probiotic fermentation refined extract and a preparation method thereof.The preparation method comprises the following steps that herba epimedii and beta-cyclodextrin are mixed, an obtained mixed solution is subjected to enzymolysis treatment through pectinase, cellulase and glycosidase and then serves as a solid-state fermentation substrate, and the herba epimedii enzymolysis probiotic fermentation refined extract is obtained; adding mixed bacteria of lactobacillus casei, bifidobacterium lactis and lactobacillus gasseri, performing solid-state fermentation, and performing vacuum freeze drying to obtain a herba epimedii probiotic fermentation refined extract; the herba epimedii probiotic fermentation refined extract is prepared by adopting an enzymolysis fermentation method in cooperation with a beta-cyclodextrin inclusion technology, the extraction efficiency, the solubility, the biological activity, the stability and other performance of effective components in herba epimedii are improved, the preparation method is simple, and operation is easy and convenient; the used materials are edible, green and safe; the process saves energy consumption, has good environmental benefits, greatly saves manpower and material resources, and can be applied to industrial large-scale production.

The invention discloses a peptide for promoting proliferation of lactobacillus gasseri as well as a preparation method and application of the peptide. The peptide comprises any one or more amino acid sequences shown in SEQ ID NO.1-17. The molecular weight is 600-1400 Da, the glutamic acid content is 12.70%-48.91%, and the biological degree, the viable count and the nitrogen source utilization rate of the lactobacillus gasseri are remarkably improved. The strain proliferation promoting peptide is high in stability, simple in process and low in production cost, and the precise design theory of a high-density culture nitrogen source of lactobacillus gasseri is further improved; and scientific theoretical support is provided for design of an optimal culture medium and acquisition of high biomass through a fermentation engineering technology.

The invention discloses a scalp care solution with the effects of controlling oil, relieving, inhibiting bacteria and adjusting scalp micro-ecology and a preparation method and application thereof.The preparation method of the scalp care solution comprises the following steps that a fermentation substrate is inoculated with saccharomycetes, primary fermentation culture is conducted for 24-72 h, then secondary fermentation culture is conducted through Lactobacillus gasseri, and the scalp care solution is obtained; wherein the fermentation substrate comprises rice, barley seeds and water; wherein the saccharomycetes comprise Saccharomyces cerevisiae (Saccharomyces cerevisiae) and Saccharomyces fibulligera (Saccharomyces fibulligera), and the saccharomycetes comprise Saccharomyces cerevisiae (Saccharomyces fibulligera) and Saccharomyces fibulligera (Saccharomyces fibulligera). The rice and the barley seeds are fermented in a microbial fermentation mode, the bioavailability of the rice and the barley seeds is improved, the content of active ingredients in the fermentation liquor prepared through the fermentation technology is increased, the fermentation liquor has the ideal effects of controlling oil, resisting inflammation, inhibiting bacteria, adjusting scalp micro-ecology and the like, the preparation technology is simple, and the method is suitable for industrial production. The fermentation conditions are mild, no organic solvent is used, and safety is achieved.

The invention discloses an anti-allergic probiotic composition as well as a preparation method and application thereof. The probiotic composition is prepared from the following raw materials in parts by weight: 10 to 50 parts of lactobacillus reuteri PG-LRL116, 10 to 50 parts of lactobacillus acidophilus, 10 to 50 parts of lactobacillus rhamnosus, 10 to 30 parts of lactobacillus gasseri, 10 to 30 parts of lactobacillus salivarius, 5 to 15 parts of cordyceps militaris aqueous extract, 5 to 15 parts of rosemary aqueous extract and 5 to 15 parts of dendrobium huoshanense yeast. The preparation method of the probiotic composition comprises the following steps: preparing the cordyceps militaris aqueous extract, the rosemary aqueous extract and the dendrobium huoshanense yeast; the preparation method comprises the following steps: uniformly mixing lactobacillus reuteri PG-LRL116, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus gasseri, lactobacillus salivarius, a cordyceps militaris aqueous extract, a rosemary aqueous extract and a dendrobium huoshanense fermentation product, so as to prepare the anti-allergic probiotic composition. The probiotic composition disclosed by the invention can be used for effectively inhibiting the occurrence of food sensitization reaction.

The present invention addresses the problem of providing a composition for dendritic cell activation that is highly safe and can be more easily ingested by many people. The composition for dendritic cell activation according to the present invention includes an exopolysaccharide produced from a Lactobacillaceae-family lactic acid bacterium. Moreover, the Lactobacillaceae-family lactic acid bacterium is preferably a Lactobacillus-genus lactic acid bacterium or a Lacticaseibacillus-genus lactic acid bacterium, and is preferably Lactobacillus delbrueckii, Lactobacillus delbrueckii subspecies bulgaricus, Lactobacillus gasseri, Lactobacillus paragasseri, or Lacticaseibacillus paracasei.

According to the probiotic composition and the application of the probiotic composition in preparation of products for preventing and treating vagina inflammation, the probiotic composition composed of lactobacillus gasseri B13.52 and lactobacillus mucus B14.46 screened from vaginal secretion of healthy women can effectively inhibit growth of escherichia coli, gardnerella and prevotella; the secretion of proinflammatory factors in vaginal epithelial cells can be obviously reduced, so that an anti-inflammatory effect is achieved.

Lactobacillus gasseri BDUP, the use thereof and a product thereof. The Lactobacillus gasseri BDUP can be used for producing GABA and preventing and / or treating depression. The Lactobacillus gasseri BDUP can produce GABA at a high yield under the condition of not additionally adding glutamic acid, can improve depressive behaviors of mice, and can provide potential strains for probiotic treatment for stress mood disorders such as depression and insomnia, and therefore has great potential market value.

The invention discloses a preparation method and application of white tea fermentation liquor with oil control and acne removal effects, lactobacillus plantarum and lactobacillus gasseri are adopted to ferment white tea, other organic reagents do not need to be added, conditions are mild in the fermentation process, the structure of active ingredients of the white tea is not damaged, and the natural activity of the white tea is kept. The production cost is saved, the stability of the product quality is fully guaranteed, chemical components such as essence are not added into the fermentation primary pulp, and the safety to a human body is improved; the white tea can be directly used as a skin care product, and the white tea fermentation liquor is rich in polyphenols, amino acids and the like, and has a synergistic effect with some fermentation product probiotics in the fermentation liquor, so that a stronger effect is shown.

The invention provides lactobacillus gasseri JY01, and belongs to the technical field of probiotic application, the lactobacillus gasseri JY01 is preserved in Guangdong Microbial Culture Collection Center on May 21, 2025, the preservation number is GDMCC NO. 66341, and the nucleotide sequence is shown as SEQ ID No: 1. The strain is obtained by separating and purifying a pickle sample produced in Liaoning region of China, has multiple functions of producing gamma-aminobutyric acid (GABA) at high yield, reducing blood sugar, resisting oxidation, regulating gastrointestinal tracts and the like, and has very high application value and economic value.

The invention discloses a lactobacillus gasseri strain capable of improving memory and promoting growth and a metagen thereof, and belongs to the technical field of microbial fermentation. A strain of lactobacillus gasseri is obtained through screening, thalli and metabiotics of the thalli are obtained through culture, the metabiotics and the reed rhizome extract form the compound, and the compound shows a synergistic interaction effect which is specifically shown as follows: in a water maze test, the incubation period of a mouse is shortened; in a rat growth test, the body length, the body width and the testis weight of the rat are all improved. The lactobacillus gasseri and the preparation method thereof have practical value on comprehensive utilization of lactobacillus gasseri and the metaplasts thereof, and also have important value in the aspects of improving memory of an organism and promoting growth.

The present invention relates to a composition for preventing or treating sarcopenia containing Lactobacillus gasseri, and specifically, to a composition for preventing, treating or improving sarcopenia, reduction of muscle mass and muscle function, and reduction of muscle strength and muscle endurance caused by causes such as stress, obesity, aging, drugs, tumors, etc., containing Lactobacillus gasseri BNR17.

The present invention provides a probiotic active antibacterial tablet for preventing and treating female reproductive system infection and a preparation method thereof. The present invention is a probiotic active antibacterial tablet for preventing and treating female reproductive system infection, comprising the following raw materials in parts by weight: 1.8-2.5 parts of Lactobacillus reuteri, 1.0-1.2 parts of Lactobacillus rhamnosus, 1.2-1.7 parts of Lactobacillus crispatus, 0.5-0.8 parts of Lactobacillus gasseri, 1.0-1.5 parts of stachyose, 0.8-1.2 parts of inulin, and 2.5-3 parts of plant extract, wherein the plant extract is prepared from the following raw materials: Bletilla striata, Chinese tallow tree leaf, Gentiana scabra, and grapefruit seed. The probiotic active antibacterial tablet prepared by the present invention has a significant inhibitory effect on IGFBP7 protein, can effectively prevent and treat female reproductive system infection, and has good tolerance and safety.

The invention discloses a lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 for transforming curcumin to produce tetrahydrocurcumin to relieve nervous anxiety, and belongs to the technical field of microorganisms. The lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 screened by the invention has the capability of converting curcumin, and can utilize curcumin and generate tetrahydrocurcumin. The invention further provides a synbiotic preparation prepared from the lactobacillus gasseri CCFM1481 and curcumin, the synbiotic preparation can be used as an anti-fatigue functional medicine, the individual behavioral memory level can be improved, the imbalance of body neurotransmitters (DA, 5-HT and NE) can be slowed down, the expression of body neuroprotection related genes (BDNF, TrkB, DRD1 and TH) can be improved, and the synbiotic preparation has a huge application prospect.

The invention belongs to the technical field of microorganisms, and particularly relates to a probiotic composition with the effects of losing weight and reducing blood sugar and application of the probiotic composition. The probiotic composition is prepared from the following raw materials: lactobacillus gasseri and lactobacillus reuteri, wherein the lactobacillus gasseri is a culture or a progeny culture of lactobacillus gasseri LG08. The lactobacillus reuteri is a culture or a progeny culture of the lactobacillus reuteri PRS-156 with the preservation number of CCTCC (China Center for Type Culture Collection) NO: M2023591 (China Center for Type Culture Collection). According to the probiotic composition containing lactobacillus gasseri and lactobacillus reuteri in a specific proportion and specific content, obesity and hyperglycemia diseases or symptoms can be obviously improved, and the probiotic composition has a good application prospect.

This invention relates to the field of probiotic technology, specifically to a combination probiotic agent for improving Alzheimer's disease and its application. The combination probiotic agent includes *Lactobacillus gasseri* LFLG-245 and inactivated *Ackermania maughanii* AKKLF; *Lactobacillus gasseri* (… Lactobacillus gasseri LFLG-245 was deposited on March 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 33952. (Ackermania pseudomallei) Akkermansia muciniphila AKKLF was deposited on March 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 33955. The combined bacterial agent provided by this invention can improve Alzheimer's disease.

The invention relates to a preparation method, a product and application of a composite wormwood probiotic metagen, and the preparation method of the metagen comprises the following steps: inoculating lactobacillus gasseri TM13 and lactobacillus crispatus LG55 into a culture medium containing a wormwood extract, and fermenting to obtain fermentation liquor; and inactivating the fermentation liquor to obtain a finished product. The lactobacillus gasseri TM13 and the lactobacillus crispatus LG55 can mutually cooperate and cooperatively grow, and the wormwood extract is added in the fermentation process, so that the fermentation biomass can be remarkably increased, the pH value can be reduced, the bacteriostatic ability of a fermentation product on vaginal harmful bacteria can be improved, particularly, the candida albicans can be inhibited, and the synergistic interaction effect of the plant extract and the strain can be exerted. The form of a metagen product can break through the limitation of application of viable bacteria, external intervention can directly act on an affected part to regulate the micro-ecological environment of the vagina, loss caused by similar extreme environments of gastrointestinal tracts is avoided, and the effect is more prominent.

The invention discloses a broiler chicken staged combined feed additive, a using method and application, and belongs to the technical field of poultry breeding, the broiler chicken staged combined feed additive comprises a first-stage additive and a second-stage additive; the first-stage additive comprises a bacillus amyloliquefaciens TL preparation, and the second-stage additive comprises a lactobacillus gasseri preparation. Through combined application of the two strains, expression of fat synthesis related genes is promoted, host lipid metabolism is regulated and controlled, the growth performance of the broiler chickens can be remarkably improved, and the method has great significance in improving the breeding efficiency of the broiler chickens.

The invention provides a vaginal flora repairing liquid and a preparation method thereof. Specifically, the repair liquid prepared from the lactobacillus paracasei CGMCC No. 1.12731, the lactobacillus rhamnosus CGMCC 24282 and the lactobacillus gasseri CGMCC No. 22909 in a specific mass ratio can be used for well killing pathogenic bacteria, has no obvious toxic or side effect and is low in cost. The broad-spectrum vaginitis bactericidal peptide YDG-C screened by the invention is further added into the repair liquid, so that the treatment effect on bacterial vaginitis can be further improved. The preparation method is simple, low in cost and suitable for large-scale popularization and application.

The invention provides a strain capable of resisting radiation damage as well as a product and application thereof, and relates to the technical field of probiotics capable of resisting radiation damage. The probiotic strains are separated from healthy breast milk and comprise lactobacillus gasseri LG02, lactococcus lactis LL6 and bifidobacterium adolescentis BA18, and the three probiotic strains can improve the survival rate after ionizing radiation; the LG02 or LL6 strain relieves damage of ionizing radiation to tissue structures of the heart, the liver, the spleen, the lung, the kidney, the stomach, the small intestine, the colon and the femur, the physiological function of an organism is maintained, and recovery of the tissue structures is accelerated; the LG02 or LL6 strain accelerates the body repair after radiotherapy, reduces the side reactions of diarrhea, stomachache, constipation and cough, and reduces the incidence rate of hematochezia and radiation pneumonitis; the LG02 or LL6 strain increases or recovers the number of leukocytes, and improves the hematopoietic ability and immunity of the organism; the LG02 or LL6 strain has the effects of inhibiting harmful bacteria, improving the anti-infection and anti-inflammation capability of the body and improving the resistance; the LG02 or LL6 strain can improve the oxidation resistance of the body and enhance the aging resistance of the body.