28 results about "Muscle functions" patented technology

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

A muscle function preservation type total temporomandibular joint prosthesis includes an articular fossa member (1) and an articular head member (2) abutting against the articular fossa member (1). The articular head member (2) includes a mandibular trailing edge fixing plate (21), a sigmoid notch fixing plate (22) and an articular head portion (23). The mandibular trailing edge fixing plate (21) is connected to a bottom end of the articular head portion (23) and extends downwards, and has a plate-shaped structure and includes a mandibular-trailing-edge-surface attaching surface. The sigmoid notch fixing plate (22) protrudes from one side of the mandibular trailing edge fixing plate (21) and extends in a direction away from the mandibular trailing edge fixing plate (21), and has a plate-shaped structure and includes a mandibular-ramus-proximal-sigmoid-notch-portion attaching surface.

The present invention relates to methods of improving muscle function in a subject suffering from a disease or condition in which muscle function is impaired, the method comprising administering an effective amount of, an inhibitor of FGFR3 signaling, an NPR-B agonist or an NPR-C agonist to said subject.

The application provides a portable multi-modal muscle health state detection system and method suitable for patients with bone fracture, and relates to the technical field of medical diagnosis. The system comprises: the flexible sensing patch comprises a flexible substrate and a bioelectrical impedance detection module, a surface electromyography detection module and a near-infrared spectroscopy muscle oxygen detection module collectively integrated on the flexible substrate, and the flexible sensing patch is used for non-invasive collection of multi-modal original monitoring data of a muscle part to be detected. The handheld host is electrically connected with the flexible sensing patch, the handheld host is used for sending control instructions to each detection module and receiving the multi-modal original monitoring data, and a comprehensive evaluation report containing three dimensions of muscle structure, muscle function and muscle metabolism is generated based on each parameter. The application overcomes the technical defects of single evaluation dimension of the existing portable device.

The present application relates to a kind of knee joint muscle function physiological age assessment characterization method, comprising the following steps: collecting the phenotype parameter of subject, establishes community sample database, and phenotype parameter includes the parameter in four categories of body composition, knee joint muscle function, cognitive function and life habit;Correlation analysis is carried out to each phenotype parameter with actual age, and the candidate phenotype parameter significantly related with age is screened;Based on candidate phenotype parameter, establish knee joint muscle function physiological age model;By calculating multi-domain standardization score, construct radar chart to carry out individual deviation characterization.The physiological age assessment characterization method provided by the present application can simultaneously output physiological age estimation result and multi-dimensional function deviation information, provide systematic technical support for early risk identification, health stratified management, individualized intervention of user, compared with prior art, in evaluation precision, information integrity and application adaptability All have obvious promotion, with good popularization and application prospect.

The utility model discloses a kind of swallowing function training devices, it is related to medical care technical field, including regulator, the inside of regulator is rotatably connected with two neck pads by bearing, the side of two neck pads is connected with positioning sleeve, the inside of positioning sleeve is slidably connected with support frame, the top of support frame is connected with massage piece, the inside of massage piece is equipped with sliding slot, the inside of sliding slot is slidably connected with sliding block.The utility model has the beneficial effect that: the swallowing function training device, the meshing between the inside gear set of regulator can drive two neck pads to rotate simultaneously, adjust its angle, and fixed in neck, logically, positioning sleeve and support frame can be vertically rotated, make massage piece adhere throat or masseter, carry out muscle massage and swallowing training, and electrode piece is installed on massage rod, adopt low-frequency current stimulation activation or cause muscle contraction, it is favorable to improve muscle function, strengthen swallowing training effect.

Provided is a composition for preventing, improving, or treating muscular disorders including sulfonamide-based compounds or salts thereof. According to the present disclosure, the sulfonamide-based compounds or salts thereof may prevent inhibition of differentiation of myoblasts by regulating the expression of PHF20 and YY1. Accordingly, since the composition may prevent or alleviate muscle loss, promote muscle regeneration, and improve muscle exercise function, balance ability, and grip strength recovery ability through increased muscles and changes in ratio of muscle fibers, the composition may be effectively used for therapeutic agents, foods, or feeds for preventing, improving or treating muscle disorders, and improving muscle functions or muscle mass.

The application discloses a kind of multi-actuator collaborative targeting control method and system of intelligent waist pad.The method is first based on anatomical static weight and muscle collaborative coupling matrix to calculate muscle function importance score, introduce historical habit and hardware state factor to generate integrated control priority;Subsequently, based on priority, construct trapezoidal motion envelope, according to the score dynamically set gradual time window, execute intermittent unloading cycle containing recovery phase;Finally, through staggered start strategy, air line bus pressure monitoring and mechanical resonance suppression algorithm, the action of multiple actuators is finely scheduled.The application realizes the precise hierarchical intervention to the core and auxiliary muscle groups of waist and back, while ensuring physiological comfort, solves the surge current and air line pressure loss problem caused by multiple load concurrency, improves the electrical safety and mechanical stability of system operation.

The present invention relates to the use of a hemp seed extract for preventing or ameliorating muscle diseases by promoting myoblast differentiation or muscle regeneration. In the present invention, the hemp seed extract may exhibit preventive or therapeutic effects on various muscle diseases by increasing muscle mass, strengthening muscle power, improving muscle function, and enhancing exercise performance, and also has an effect of improving muscle function in healthy individuals in addition to treating muscle diseases.

The present application relates to the technical field of signal processing, and discloses a muscle tension nerve feedback electric signal data processing method, which comprises preliminary noise reduction, noise suppression, feature extraction, determination of muscle tension baseline and nerve feedback threshold, muscle tension data calculation and correction: a multi-stage noise reduction mode combining sliding average filtering, median filtering and wavelet transform is adopted to effectively remove periodic, pulse and high-frequency noise; the root mean square value and discrete Fourier transform are used to extract features from amplitude and frequency components in multiple dimensions, so as to accurately reflect physiological information such as muscle contraction strength and fatigue state; the muscle tension baseline is determined by collecting individual relaxation state signals, and the nerve feedback threshold is set in combination with subjective feeling, so that the individualization and accuracy of evaluation are enhanced; muscle tension data are calculated in real time, and are dynamically corrected according to energy characteristics of different frequency bands, so that the evaluation result is further optimized, and high-precision and reliable data support is provided for muscle function evaluation and nerve feedback treatment.

The present invention relates to a composition for increasing muscle mass, improving muscle function, or preventing or treating muscle disease, comprising Phocaeicola vulgatus or cultures thereof. In addition, the present invention relates to a method for increasing muscle mass, improving muscle function,, or preventing or treating muscular disease, comprising administering or taking a composition comprising Phocaeicola vulgatus or a culture thereof as an active ingredient to an individual in need. The Phocaeicola vulgatus of the present invention has the outstanding effect of increasing muscle strength, increasing muscle weight, and increasing muscle fiber.

The application discloses application of papyriquinone in treatment of muscular dystrophy. The inventors find that papyriquinone can be combined with ERRa, activate ERRa and downstream signal pathways, promote muscle cell differentiation, improve muscle function, promote skeletal muscle regeneration, and finally plays a therapeutic role on Duchenne muscular dystrophy.

This invention belongs to the field of small molecule pharmaceutical compounds and relates to the application of trimetazidine in the preparation of drugs for treating glycogen storage diseases. This invention provides a novel treatment strategy for glycogen storage diseases, discovering that the small molecule compound trimetazidine can reduce the load on lysosomal pathways, further reducing cellular glycogen accumulation, thus achieving a therapeutic effect on glycogen storage diseases. In animal experiments, observations of skeletal muscle movement in mice confirmed that trimetazidine significantly enhances muscle function and strength in mice with glycogen storage diseases. Therefore, trimetazidine can be used clinically for the prevention or treatment of glycogen storage diseases, and possesses the advantages of small molecular weight, oral administration, and low cost for industrialization.

To provide compositions for use in increasing muscle mass, preventing muscle atrophy, promoting muscle growth, and treating various other conditions and diseases, and methods for the treatment.SOLUTION: A composition for increasing muscle mass comprises: a. dileucine; b. leucine; and c. pharmaceutically acceptable carriers thereof. Disclosed compositions comprise dileucine and leucine and pharmaceutically acceptable salts thereof. The compositions are administered to subjects in need thereof to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.SELECTED DRAWING: None

The application provides a use of Qixuekang in preparation of a medicine for improving aging. Experimental researches prove that Qixuekang can significantly improve natural aging of mice, improve the exercise capacity and muscle function of old mice, and Qixuekang can improve the mitochondrial membrane potential, increase the expression of mitochondrial neogenesis related genes and reduce the production of active oxygen, improve the mitochondrial function of replicative senescent cells, and further improve the replicative senescence state of the natural aging cell line 2BS.

This product is an ankle support sticker that is attached to the lower part of the outer ankle bone to promote blood circulation, improve core muscle function, and increase flexibility.

This invention provides a method for constructing and applying an animal model of sarcopenia, belonging to the field of animal model construction technology. This invention uses... adora2b Targeting genes, by knocking out the aforementioned adora2b Genetic constructing of a sarcopenia animal model. This invention uses CRISPANT technology to construct a knockout gene. adora2b Zebrafish model of genes adora2b Mutant zebrafish exhibit muscle atrophy and dysfunction, showing reduced muscle fluorescence area and average intensity, increased cellular senescence, and significantly decreased expression of muscle function-related genes, indicating that the mutant zebrafish have experienced muscle degeneration and dysfunction. The present invention provides… adora2b Mutant zebrafish serve as an animal model of sarcopenia. adora2b Research on the relationship between gene mutations and the pathogenesis of sarcopenia, as well as the screening of drugs for the prevention and treatment of sarcopenia, have laid a theoretical foundation.

A composition contains Nicotinamide and Vitamin B6, for example pyridoxine. The composition may be an oral nutritional composition, for example an infant formula, a follow up formula, a nutritional supplement, an oral nutritional supplement, a food product. The composition can be administered to an individual in need thereof for promoting muscle growth and / or for maintaining and / or increasing muscle function and / or muscle mass in infants and children. For example, the composition can be useful for increasing muscle function and / or muscle mass by modulating muscle stem cells.

The application is suitable for the technical field of intelligent algorithm, and provides a sarcopenia rehabilitation strategy generation method and related equipment, including: acquiring four-limb skeletal muscle data, whole-body muscle density data and bone density value data of a target user, and acquiring muscle function data of the target user according to a user type of the target user and according to a preset rule; performing profiling on the target user by a preset diagnosis algorithm based on the four-limb skeletal muscle data, the whole-body muscle density data and the muscle function data, to obtain a profiling result; and selecting a rehabilitation strategy for the target user in a preset database according to the user type, the profiling result and the bone density value data.

The application discloses an individualized muscle function growth adaptive orthodontic retainer, a design method and a system, relates to the technical field of tooth correction, and the method comprises the following steps: constructing an annual physiological growth value; constructing a front tooth area inertia coefficient and a back tooth area inertia coefficient; constructing an initial tooth and jaw digital model; determining a target tooth and jaw digital model of optimized occlusion relationship according to the initial tooth and jaw digital model; constructing a front tooth rebound prediction model and a back tooth rebound prediction model according to the front tooth area inertia coefficient, the back tooth area inertia coefficient, the initial tooth and jaw digital model and the target tooth and jaw digital model; generating an orthodontic retainer model according to the target tooth and jaw digital model; respectively constructing avoidance spaces on tooth grooves and tracks of the orthodontic retainer model according to the annual physiological growth value, the front tooth rebound prediction model and the back tooth rebound prediction model; and respectively adjusting the lip baffle wall thickness and the cheek screen wall thickness of the orthodontic retainer model according to the front tooth area inertia coefficient and the back tooth area inertia coefficient. By adopting the application, the orthodontic retainer model is more in line with anatomical physiological facts, and the correction effect is better.

This application belongs to the field of medical device technology and provides a smart mirror for orofacial muscle function training, including: a support base; a device body disposed on the support base, the support base supporting the device body; and a single lens disposed on the device body, the single lens including a reflective surface and a single-transparent surface disposed opposite to each other, a display screen disposed on the single-transparent surface, the single-transparent surface transmitting light unidirectionally towards the reflective surface, and the display screen displaying light towards the single-transparent surface; at least one of the support base and the device body is provided with a circuit board. The single lens in this invention can both display the content on the display screen and also function as a reflective lens, allowing patients to follow the images on the display screen for orofacial muscle function training, and enabling real-time comparison and correction, improving the patient's training accuracy. The device can also capture images of the patient's face using a camera, helping the patient better assess the training effect and improving the overall effectiveness of the orofacial muscle function training.

This invention discloses a muscle electrical stimulation device and method. The device includes: an electrical stimulation component, which is a flexible structure with electrode contacts on its surface, and can be flexibly fitted onto the muscle to be stimulated; a control module, wiredly connected to the electrical stimulation component, which has multiple preset electrical stimulation programs and executes the corresponding programs according to different muscle sites, controlling the electrical stimulation component to apply electrical stimulation to the muscle; a power supply unit, connected to the control module, providing power to the muscle electrical stimulation device; and fixing components, disposed on both sides of the electrical stimulation component. The device provided by this invention allows for passive muscle movement through electrical stimulation without requiring active human effort, effectively maintaining muscle activity and blood circulation. It is suitable for muscle function maintenance scenarios in confined spaces, offering convenience and strong applicability.

Provided herein are compositions and methods of treating muscular dystrophy by administering an effective amount of a composition comprising a bifunctional protein comprising a first binding moiety that binds to a muscle-specific molecule and a second functional domain that activates Notch signaling, thereby activating Notch signaling in muscle tissue in space and time to potentiate satellite cell in situ renewal, and thus enhance muscle repair / regeneration to improve muscle function, as a treatment for various muscular dystrophies and muscle-reducing conditions. Also provided are engineered DLL4 extracellular domains and protein constructs comprising the same.

A composition and a method for use in neuroprotection or improving cognitive ability, enhancing athletic performance or improving muscle function, combatting inflammation, combatting aging, extending lifespan or improving healthspan, managing stress or improving mood. The composition comprises: salidroside or a pharmaceutically acceptable salt, ester, or derivative thereof; and ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog, or derivative thereof.

The application discloses a postoperative patient limb function recovery intelligent evaluation and rehabilitation training path planning system, which comprises a multi-modal data acquisition module for acquiring postoperative limb movement data of a patient, and an intelligent evaluation module for calculating a limb function recovery index FR multidimensional precise evaluation based on the movement data; multi-modal sensor data (IMU, EMG, depth camera) are fused to cover whole-dimensional information such as kinematics and muscle function, the data integrity is improved by more than 60%, a dynamic model is used for tracking a recovery trend, and the evaluation precision is significantly improved compared with a traditional scheme. Personalized intelligent training: a personalized scheme containing 10-15 actions is generated through reinforcement learning, and a rehabilitation cycle is shortened by 23%; training parameters are dynamically adjusted in real time, and fatigue is warned, the fatigue occurrence rate is reduced from 65% to 39%, and safety and compliance are improved.

1. Name of the product in this design: Vibration Rehabilitation Training Bed. 2. Purpose of this design: To improve muscle function, balance, and coordination in patients with motor dysfunction. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention discloses a strain of *Lactobacillus delbrueckii* with muscle-protecting function during fat loss, its products, and applications, belonging to the field of microbial technology. The invention discloses *Lactobacillus delbrueckii* subspecies Turb8, with accession number CGMCC No. 35627. This strain or its preparations can effectively prevent or improve muscle loss and functional decline during the use of fat-loss drugs such as GLP-1 receptor agonists (e.g., liraglutide, smegglutide), achieving the effect of "fat loss without muscle loss." While maintaining the original weight-loss effect of fat-loss drugs, the strain of this invention can significantly increase the user's lean body mass percentage, increase lower limb muscle mass, increase muscle fiber cross-sectional area, and improve muscle function indicators such as limb strength and suspension endurance. This invention also relates to bacterial agents containing this strain, various preparations, and their application in the preparation of products for improving (especially drug-induced) muscle loss.

Exemplary methods, compositions and uses thereof can be provided for preventing, reducing and / or treating loss of muscle function. In particular, e.g., it is possible to administer to a subject a pharmaceutical composition comprising a therapeutically effective amount of an agent that enhances Interleukin-6 (IL) release during exercise, and optionally a pharmaceutically acceptable carrier or excipient.