138 results about "Muscle functions" patented technology

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for improving muscle functions and application. The nutritional composition for improving the muscle function, provided by the invention, is prepared from the following components in parts by mass: 40 to 60 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride and 20 to 70 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. A specific amount of OPO and OPL are compounded, and the two components have a synergistic effect, so that the exercise amount and the ATP content of an organism are remarkably increased, sarcopenia is relieved by improving energy metabolism, the muscle function is improved, and the food has a wide application prospect in the field of food and is worthy of popularization and application. The food can be used in health-care food, formula food for special medical purposes, infant formula food or special diet food.

The invention discloses a muscle function rhythm analysis method and system based on unhealthy side cooperation and electronic equipment, and relates to the technical field of data processing. The method comprises the following steps: acquiring an uninjured side electromyographic signal of a patient, and a joint angle signal and a movement track signal of an affected side; based on the electromyographic signal, extracting an uninjured-side cooperative adjustment decline trajectory, and based on the joint angle signal and the motion trajectory signal, extracting an affected-side function take-over response trajectory; identifying a critical point of affected-side function takeover; calculating a first change curvature and a second change curvature, and taking a time point when the first change curvature is greater than the second change curvature for the first time as a motion stability starting point of the affected side; extreme point distribution is extracted, the motion rhythm period of the affected side is determined, and the time length change trend is calculated; and based on the time length change trend, determining a function autonomous maintenance score, and calculating a muscle function rhythm index of the upper limb of the affected side according to the function autonomous maintenance score. By implementing the technical scheme provided by the invention, the accuracy of analyzing the motion data of the limb on the affected side can be improved.

The invention discloses an application of ganoderma lucidum spore oil in preparation of a medicine or health food for improving sarcopenia. Ganoderma lucidum spore oil can effectively improve weight loss and muscle hypofunction induced by glucocorticoid, and improve the holding power and exercise tolerance level of the body; meanwhile, the skeletal muscle mass and the muscle fiber cross sectional area can be increased, and the skeletal muscle tissue morphological structure is improved; in addition, the ganoderma lucidum spore oil can improve the oxidation resistance of the body and skeletal muscle and reduce the oxidative stress level, so that the skeletal muscle injury related to aging is relieved on the whole. Therefore, the ganoderma lucidum spore oil has a definite application value in the aspect of improving the skeletal muscle function.

The present invention relates to a use of Cyclo-His Pro (CHP) alone or zinc and Cyclo-His Pro (zinc and CHP, Cycloz) for inhibiting muscle loss or alleviating muscle function decline caused by anti-obesity drugs. More specifically, the present invention provides a pharmaceutical composition and a health functional food composition, which when administered in combination with an anti-obesity drug, exhibit an effect of inhibiting the anti-obesity drug-induced side effect of muscle loss while maintaining a weight loss effect, and exhibit an effect of preventing, alleviating, or treating sarcopenic obesity, and a method for inhibiting muscle loss or alleviating muscle function decline caused by an anti-obesity drug and a method for preventing, alleviating or treating sarcopenic obesity using same.

The present invention is a biarticular forearm support brace comprising a hand wrap, an arm wrap, vibrational motors, and EMG sensors. In the preferred embodiment of the present invention, the present invention further comprises medical-grade materials with elastic properties and a plurality of straps. The present invention takes the tension off the extensor muscles in the forearm by pulling the hand towards the elbow, replacing muscle function and allowing the extensor muscles in the forearm to be shortened while not being contracted.

It was confirmed that probiotic metabolites of the present invention protect muscle cells and promote differentiation of muscle fibers. In addition, it was confirmed in an animal model of muscle atrophy or sarcopenia induced by dexamethasone that probiotic metabolites increased muscle mass and muscle function, inhibited expression of factors associated with muscle degradation, and increased expression of factors associated with muscle synthesis and regeneration. It was confirmed that probiotic metabolites contribute to alleviation of muscle atrophy by regulating sugar, amino acid, and fatty acid metabolism altered by dexamethasone.

The invention discloses lactobacillus delbrueckii with a muscle protection function in a fat reducing period as well as a product and application thereof, belongs to the technical field of microorganisms, and discloses lactobacillus delbrueckii subsp. Lactis Turb8 with the preservation number of CGMCC No.35627. The lactobacillus delbrueckii subsp. Lactis Turb8 has the advantages that the preservation number is CGMCC No.35627; the strain or the preparation thereof can effectively prevent or improve the accompanying problems of muscle loss and function decline in the process of applying fat-reducing drugs such as GLP-1 receptor agonists (such as liraglutide and semeglutide), and the effect of reducing fat but not reducing muscle is achieved. The strain disclosed by the invention can be used for remarkably increasing the lean body mass ratio of a user, increasing the muscle mass of lower limbs, increasing the cross sectional area of muscle fibers and improving muscle function indexes such as strength of four limbs and suspension endurance while keeping the original weight-reducing effect of a fat-reducing medicine. The invention also relates to microbial agents comprising this strain, various preparations, their use in the preparation of products for ameliorating (in particular drug-induced) muscle reduction.

The invention relates to the technical field of biological medicine, in particular to an oligonucleotide molecule for inhibiting expression of ACTRIIB and application of the oligonucleotide molecule. The oligonucleotide molecule comprises at least 12 contiguous nucleotides of any one of the nucleotide sequences of SEQ ID NO: 1 to SEQ ID NO: 70, SEQ ID NO: 141 to SEQ ID NO: 185, SEQ ID NO: 231 to SEQ ID NO: 244 and SEQ ID NO: 71 to SEQ ID NO: 140, SEQ ID NO: 186 to SEQ ID NO: 230, SEQ ID NO: 245 to SEQ ID NO: 258, or a sequence that differs from the at least 12 contiguous nucleotides by no more than 3 nucleotides, or a sequence complementary thereto, the nucleotides being in a modified or unmodified state. The oligonucleotide molecule mediates RNA interference on the ACTRIIB, so that muscle building, muscle function improvement, exercise capability enhancement and prevention or treatment of muscle system related diseases are realized.

The invention provides a peripheral facial paralysis rehabilitation device. The peripheral facial paralysis rehabilitation device comprises a host and at least one stimulation patch electrically connected with the host, the stimulation patch is prefabricated into a special-shaped geometric structure matched with the anatomical direction of facial muscles, and at least integrates a myoelectricity acquisition part, an electrical stimulation part and a heating part; the host is configured to collect a surface electromyographic signal sequence of a user under a specified facial action through the electromyographic collection part of the worn stimulation patch, and the stimulation patch worn by the user is in one-to-one correspondence with target facial muscles involved in the specified facial action; determining at least one muscle function state index according to the surface electromyogram signal sequence; determining a working mode according to the muscle function state index; and controlling the electrical stimulation part and / or the heating part of the stimulation patch worn by the user to work according to the working parameters corresponding to the determined working mode.

The portable controllable suspension vibrator for rehabilitation is installed on a rope of a suspension instrument and comprises a shell, a vibration motor and two vibration plates, the vibration motor is arranged in the shell, and the two vibration plates are symmetrically arranged at the two ends of the shell and extend in the length direction of the shell; the front end faces of the two vibration plates are each provided with a connecting piece, and the two connecting pieces are symmetrically arranged and detachably connected with the corresponding ropes. According to the utility model, the suspension apparatus of the rehabilitation training device is connected with the vibrating plate through the rope, the vibrating plate is vibrated through the vibrating motor, and the vibration is transmitted to a patient on the rehabilitation training device through the rope, so that the patient is subjected to vibration treatment, and the rehabilitation training device is used for assisting in treating neuromuscular diseases, relieving pain, activating muscle functions and the like. The device is externally connected to the rehabilitation training device and can be adjusted according to the requirements of a patient, the structure of an original rehabilitation training device does not need to be changed, installation is convenient, and cost is low.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

The present application belongs to the field of nutritional biotechnology, in particular, the present application relates to an anti-aging composition and its application. Through a large number of research and screening, it is found that the combination of specific grape seed extract, ergothioneine and specific black ginger extract can exert the synergistic effect of the three, fully exert the grape seed extract (antioxidant, free radical scavenging), black ginger (testosterone enhancement, muscle function enhancement), ergothioneine (protection of mitochondria and lysosome), form a multi-pathway mechanism, multi-level improvement of aging, improvement of fertility and muscle capacity.

A muscle function preservation type total temporomandibular joint prosthesis includes an articular fossa member (1) and an articular head member (2) abutting against the articular fossa member (1). The articular head member (2) includes a mandibular trailing edge fixing plate (21), a sigmoid notch fixing plate (22) and an articular head portion (23). The mandibular trailing edge fixing plate (21) is connected to a bottom end of the articular head portion (23) and extends downwards, and has a plate-shaped structure and includes a mandibular-trailing-edge-surface attaching surface. The sigmoid notch fixing plate (22) protrudes from one side of the mandibular trailing edge fixing plate (21) and extends in a direction away from the mandibular trailing edge fixing plate (21), and has a plate-shaped structure and includes a mandibular-ramus-proximal-sigmoid-notch-portion attaching surface.

The present invention relates to methods of improving muscle function in a subject suffering from a disease or condition in which muscle function is impaired, the method comprising administering an effective amount of, an inhibitor of FGFR3 signaling, an NPR-B agonist or an NPR-C agonist to said subject.

The invention discloses a cortex and muscle coupling analysis method based on information flow decomposition. The method comprises the following steps: collecting and pre-processing EEG signals and EMG signals of multiple channels; constructing a cortical muscle function connection network through an ordinal number division conversion method; using a Helmholtz-Hough-Ketaria decomposition method to decompose and remove a circulating flow in the cortex muscle function connection network to obtain a residual gradient flow network; analyzing and comparing topological characteristics of the cortex muscle function connection network and the gradient flow network by using node access intensity; performing causal hierarchy analysis on the gradient flow network; the node input intensity and the causal hierarchy are used as classification features, and a support vector machine is used as a classifier for classification. According to the method, a high-credibility cortical muscle function connection network is constructed through an ordinal number division conversion network, the network is decoupled into a circulation flow and a gradient flow through Helmholtz-Hough-Cotela decomposition, and finally, the information transmission and causal relationship in a cortical muscle coupling system is intuitively reflected by utilizing causal hierarchical division.

The invention discloses a screening method of skeletal muscle senescence markers, clock construction and a kit, and belongs to the technical field of biomedical engineering. The method comprises the following steps: acquiring multi-modal biomarker data of an individual, wherein the multi-modal biomarker data comprises an inflammatory marker, a metabolic marker, a hormone marker and a muscle function marker; inputting the data into a trained skeletal muscle biological age prediction model to obtain skeletal muscle biological age (SMBA); based on the skeletal muscle biological age (SMBA), screening out a specific methylation site set related to the skeletal muscle senescence state from the methylation sites of the whole genome; constructing a methylation aging clock model by using methylation data of the site set; and finally, accurately predicting and evaluating the skeletal muscle senescence state of an individual by using the model. According to the invention, conversion from multi-modal clinical indexes to specific single-dimensional molecular markers is realized, and the constructed senescence clock model and derivative products can be used for personalized evaluation and early risk early warning of skeletal muscle senescence.

The present disclosure provides a method for treating a condition or disease associated with weight gain, the method comprising co-administering an apelin receptor agonist and a GLP-1 receptor agonist. Also provided are methods of increasing overall weight loss in a subject relative to weight loss caused by administration of a predetermined amount of a GLP-1 receptor agonist alone. In some embodiments, the methods are used to maintain or maintain muscle mass, muscle function, and / or muscle strength in a subject undergoing a weight loss therapy.

The utility model aims to provide the auxiliary recovery equipment for the leg sport injury, which can improve the recovery speed of a patient with the leg injury and has the function of activating deep muscles. The lifting assembly is arranged on the base and used for adjusting the height, the sliding seat is in sliding fit with the lifting assembly and used for adjusting the front-back position, the angle adjusting assembly is rotationally connected to the sliding seat, and the leg fixing seat is rotationally connected with the angle adjusting assembly. A placing cavity for placing legs is formed in the leg fixing seat, a plurality of micro-current sheets are arranged in the placing cavity, and a plurality of fixing belts for fixing the legs are arranged at the upper part of the leg fixing seat. The leg rehabilitation assisting device is applied to the technical field of leg rehabilitation assisting devices.

The invention belongs to the field of pharmaceutical compositions, and relates to a composition for improving exercise fatigue and application thereof. The composition comprises milk-derived protein peptides, cod collagen peptides, vitamins and minerals, and intervention of the composition can help to improve exercise fatigue and improve muscle quality and muscle exercise ability. The composition has both functionality and nutrition, and shows a wide application prospect in the aspects of improving muscle functions and athletic ability.

A method for treating lysosomal storage disease in an individual is provided, comprising administering to the individual a ketogenic agent, a composition comprising a mixture of metabolic enhancing agents, or administering both the ketogenic agent and the metabolic enhancing composition. The treatment is effective to improve muscle function, autophagic activity and / or mitochondrial capacity in an individual having a lysosomal storage disease.

The application provides a portable multi-modal muscle health state detection system and method suitable for patients with bone fracture, and relates to the technical field of medical diagnosis. The system comprises: the flexible sensing patch comprises a flexible substrate and a bioelectrical impedance detection module, a surface electromyography detection module and a near-infrared spectroscopy muscle oxygen detection module collectively integrated on the flexible substrate, and the flexible sensing patch is used for non-invasive collection of multi-modal original monitoring data of a muscle part to be detected. The handheld host is electrically connected with the flexible sensing patch, the handheld host is used for sending control instructions to each detection module and receiving the multi-modal original monitoring data, and a comprehensive evaluation report containing three dimensions of muscle structure, muscle function and muscle metabolism is generated based on each parameter. The application overcomes the technical defects of single evaluation dimension of the existing portable device.

The present application relates to a kind of knee joint muscle function physiological age assessment characterization method, comprising the following steps: collecting the phenotype parameter of subject, establishes community sample database, and phenotype parameter includes the parameter in four categories of body composition, knee joint muscle function, cognitive function and life habit;Correlation analysis is carried out to each phenotype parameter with actual age, and the candidate phenotype parameter significantly related with age is screened;Based on candidate phenotype parameter, establish knee joint muscle function physiological age model;By calculating multi-domain standardization score, construct radar chart to carry out individual deviation characterization.The physiological age assessment characterization method provided by the present application can simultaneously output physiological age estimation result and multi-dimensional function deviation information, provide systematic technical support for early risk identification, health stratified management, individualized intervention of user, compared with prior art, in evaluation precision, information integrity and application adaptability All have obvious promotion, with good popularization and application prospect.

The invention belongs to the technical field of fermented food, and particularly relates to an application of a ginseng fermentation liquor of phytobacterium plantarum HCS03-001 in an anti-fatigue product. The preparation method comprises the following steps: adding water into ginseng, extracting twice, combining extracting solutions, adding isomaltooligosacharide, and sterilizing to obtain a fermentation substrate; the preparation method comprises the following steps: carrying out activation culture on plant lactobacillus HCS03-001 to obtain an activated bacterium solution, inoculating a fermentation substrate, carrying out fermentation and centrifugation, and sterilizing the supernate to obtain ginseng fermentation liquor, so as to play a remarkable anti-fatigue role by regulating ATP synthesis and lactic acid metabolism in vivo, the composition can be used for accelerating metabolism recovery after exercise, prolonging exhaustive exercise time, improving skeletal muscle tolerance, reducing exercise muscle injury and the like, and can be applied to preparation of exercise nutrition / anti-fatigue food, health care products or medicines, including products for regulating sex hormone metabolism level and promoting protein synthesis and muscle function recovery. The method has the advantages of safety, high efficiency and wide application range.

The application discloses a biological age evaluation method, comprising the following steps: obtaining a key protein index of a person to be evaluated, inputting an improved biological age evaluation model I, and obtaining the biological age of the person to be evaluated; the improved biological age evaluation model I is obtained based on an elastic network regression algorithm by taking proteomic data and body composition age of an individual as training data. The application also discloses a construction method of the model, i.e., a two-step method. The application allows a user to calculate the biological age according to the proteomic data, realizes personalized monitoring of muscle aging state, and has great guiding significance in identifying individuals with early muscle function decline and formulating personalized and accurate anti-aging schemes.

The present application relates to the technical field of pattern recognition, in particular to a stroke rehabilitation evaluation method based on brain muscle function network features, comprising the following steps: S1, collecting electroencephalogram signals and electromyogram signals, collecting electroencephalogram signals and electromyogram signals of a stroke patient under a hand dynamometer test; S2, respectively pre-processing the electroencephalogram signals and electromyogram signals; S3, constructing a variational mode decomposition transfer entropy; S4, constructing a CMFN model based on EEG and EMG; S5, brain muscle function network analysis. The method considers that the research on motor recovery of stroke stays in analyzing the consistency or coupling relationship changes between the cerebral cortex and the muscle, realizes the quantification of stroke evaluation, and greatly improves the evaluation accuracy.

A pre-workout lollipop composition for enhancing workout performance and supporting muscle function and recovery is disclosed. The lollipop is a unique blend of essential pre-workout ingredients, comprising 1.5 weight percentage caffeine anhydrous, 10 weight percentage beta alanine, 0.05 weight percentage vitamins B6 and B12, 50 weight percentage mixture of corn syrup and brown rice syrup, 15 weight percentage L-citrulline, 1.5 weight percentage electrolytes, and 22 weight percentage natural flavors and sweeteners. The lollipop is consumed about 30 minutes before physical activity, offering a convenient and effective supplement solution. In one embodiment, the ingredients are combined into a syrup base, mixed uniformly, and then poured into molds to form the lollipops. This innovative delivery system provides rapid absorption of ingredients in the mouth and stomach, enhancing alertness, endurance, and overall workout performance.

Disclosed herein are compounds for treating and / or managing muscular dystrophy. According to the embodiment of the invention, the compound can inhibit the activity of DPP-IV, so that the muscle nutrition related protein level in muscles is up-regulated, and the integral improvement of muscle functions is realized. Embodiments herein also result in a composition for upregulating muscle nutrition related protein levels in muscle cells.

The utility model discloses a kind of swallowing function training devices, it is related to medical care technical field, including regulator, the inside of regulator is rotatably connected with two neck pads by bearing, the side of two neck pads is connected with positioning sleeve, the inside of positioning sleeve is slidably connected with support frame, the top of support frame is connected with massage piece, the inside of massage piece is equipped with sliding slot, the inside of sliding slot is slidably connected with sliding block.The utility model has the beneficial effect that: the swallowing function training device, the meshing between the inside gear set of regulator can drive two neck pads to rotate simultaneously, adjust its angle, and fixed in neck, logically, positioning sleeve and support frame can be vertically rotated, make massage piece adhere throat or masseter, carry out muscle massage and swallowing training, and electrode piece is installed on massage rod, adopt low-frequency current stimulation activation or cause muscle contraction, it is favorable to improve muscle function, strengthen swallowing training effect.