85 results about "Muscle functions" patented technology

The invention discloses an application of ganoderma lucidum spore oil in preparation of a medicine or health food for improving sarcopenia. Ganoderma lucidum spore oil can effectively improve weight loss and muscle hypofunction induced by glucocorticoid, and improve the holding power and exercise tolerance level of the body; meanwhile, the skeletal muscle mass and the muscle fiber cross sectional area can be increased, and the skeletal muscle tissue morphological structure is improved; in addition, the ganoderma lucidum spore oil can improve the oxidation resistance of the body and skeletal muscle and reduce the oxidative stress level, so that the skeletal muscle injury related to aging is relieved on the whole. Therefore, the ganoderma lucidum spore oil has a definite application value in the aspect of improving the skeletal muscle function.

The present invention is a biarticular forearm support brace comprising a hand wrap, an arm wrap, vibrational motors, and EMG sensors. In the preferred embodiment of the present invention, the present invention further comprises medical-grade materials with elastic properties and a plurality of straps. The present invention takes the tension off the extensor muscles in the forearm by pulling the hand towards the elbow, replacing muscle function and allowing the extensor muscles in the forearm to be shortened while not being contracted.

The invention discloses lactobacillus delbrueckii with a muscle protection function in a fat reducing period as well as a product and application thereof, belongs to the technical field of microorganisms, and discloses lactobacillus delbrueckii subsp. Lactis Turb8 with the preservation number of CGMCC No.35627. The lactobacillus delbrueckii subsp. Lactis Turb8 has the advantages that the preservation number is CGMCC No.35627; the strain or the preparation thereof can effectively prevent or improve the accompanying problems of muscle loss and function decline in the process of applying fat-reducing drugs such as GLP-1 receptor agonists (such as liraglutide and semeglutide), and the effect of reducing fat but not reducing muscle is achieved. The strain disclosed by the invention can be used for remarkably increasing the lean body mass ratio of a user, increasing the muscle mass of lower limbs, increasing the cross sectional area of muscle fibers and improving muscle function indexes such as strength of four limbs and suspension endurance while keeping the original weight-reducing effect of a fat-reducing medicine. The invention also relates to microbial agents comprising this strain, various preparations, their use in the preparation of products for ameliorating (in particular drug-induced) muscle reduction.

The invention relates to the technical field of biological medicine, in particular to an oligonucleotide molecule for inhibiting expression of ACTRIIB and application of the oligonucleotide molecule. The oligonucleotide molecule comprises at least 12 contiguous nucleotides of any one of the nucleotide sequences of SEQ ID NO: 1 to SEQ ID NO: 70, SEQ ID NO: 141 to SEQ ID NO: 185, SEQ ID NO: 231 to SEQ ID NO: 244 and SEQ ID NO: 71 to SEQ ID NO: 140, SEQ ID NO: 186 to SEQ ID NO: 230, SEQ ID NO: 245 to SEQ ID NO: 258, or a sequence that differs from the at least 12 contiguous nucleotides by no more than 3 nucleotides, or a sequence complementary thereto, the nucleotides being in a modified or unmodified state. The oligonucleotide molecule mediates RNA interference on the ACTRIIB, so that muscle building, muscle function improvement, exercise capability enhancement and prevention or treatment of muscle system related diseases are realized.

The invention provides a peripheral facial paralysis rehabilitation device. The peripheral facial paralysis rehabilitation device comprises a host and at least one stimulation patch electrically connected with the host, the stimulation patch is prefabricated into a special-shaped geometric structure matched with the anatomical direction of facial muscles, and at least integrates a myoelectricity acquisition part, an electrical stimulation part and a heating part; the host is configured to collect a surface electromyographic signal sequence of a user under a specified facial action through the electromyographic collection part of the worn stimulation patch, and the stimulation patch worn by the user is in one-to-one correspondence with target facial muscles involved in the specified facial action; determining at least one muscle function state index according to the surface electromyogram signal sequence; determining a working mode according to the muscle function state index; and controlling the electrical stimulation part and / or the heating part of the stimulation patch worn by the user to work according to the working parameters corresponding to the determined working mode.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

The present application belongs to the field of nutritional biotechnology, in particular, the present application relates to an anti-aging composition and its application. Through a large number of research and screening, it is found that the combination of specific grape seed extract, ergothioneine and specific black ginger extract can exert the synergistic effect of the three, fully exert the grape seed extract (antioxidant, free radical scavenging), black ginger (testosterone enhancement, muscle function enhancement), ergothioneine (protection of mitochondria and lysosome), form a multi-pathway mechanism, multi-level improvement of aging, improvement of fertility and muscle capacity.

A muscle function preservation type total temporomandibular joint prosthesis includes an articular fossa member (1) and an articular head member (2) abutting against the articular fossa member (1). The articular head member (2) includes a mandibular trailing edge fixing plate (21), a sigmoid notch fixing plate (22) and an articular head portion (23). The mandibular trailing edge fixing plate (21) is connected to a bottom end of the articular head portion (23) and extends downwards, and has a plate-shaped structure and includes a mandibular-trailing-edge-surface attaching surface. The sigmoid notch fixing plate (22) protrudes from one side of the mandibular trailing edge fixing plate (21) and extends in a direction away from the mandibular trailing edge fixing plate (21), and has a plate-shaped structure and includes a mandibular-ramus-proximal-sigmoid-notch-portion attaching surface.

The present invention relates to methods of improving muscle function in a subject suffering from a disease or condition in which muscle function is impaired, the method comprising administering an effective amount of, an inhibitor of FGFR3 signaling, an NPR-B agonist or an NPR-C agonist to said subject.

The invention discloses a screening method of skeletal muscle senescence markers, clock construction and a kit, and belongs to the technical field of biomedical engineering. The method comprises the following steps: acquiring multi-modal biomarker data of an individual, wherein the multi-modal biomarker data comprises an inflammatory marker, a metabolic marker, a hormone marker and a muscle function marker; inputting the data into a trained skeletal muscle biological age prediction model to obtain skeletal muscle biological age (SMBA); based on the skeletal muscle biological age (SMBA), screening out a specific methylation site set related to the skeletal muscle senescence state from the methylation sites of the whole genome; constructing a methylation aging clock model by using methylation data of the site set; and finally, accurately predicting and evaluating the skeletal muscle senescence state of an individual by using the model. According to the invention, conversion from multi-modal clinical indexes to specific single-dimensional molecular markers is realized, and the constructed senescence clock model and derivative products can be used for personalized evaluation and early risk early warning of skeletal muscle senescence.

The invention belongs to the field of pharmaceutical compositions, and relates to a composition for improving exercise fatigue and application thereof. The composition comprises milk-derived protein peptides, cod collagen peptides, vitamins and minerals, and intervention of the composition can help to improve exercise fatigue and improve muscle quality and muscle exercise ability. The composition has both functionality and nutrition, and shows a wide application prospect in the aspects of improving muscle functions and athletic ability.

The application provides a portable multi-modal muscle health state detection system and method suitable for patients with bone fracture, and relates to the technical field of medical diagnosis. The system comprises: the flexible sensing patch comprises a flexible substrate and a bioelectrical impedance detection module, a surface electromyography detection module and a near-infrared spectroscopy muscle oxygen detection module collectively integrated on the flexible substrate, and the flexible sensing patch is used for non-invasive collection of multi-modal original monitoring data of a muscle part to be detected. The handheld host is electrically connected with the flexible sensing patch, the handheld host is used for sending control instructions to each detection module and receiving the multi-modal original monitoring data, and a comprehensive evaluation report containing three dimensions of muscle structure, muscle function and muscle metabolism is generated based on each parameter. The application overcomes the technical defects of single evaluation dimension of the existing portable device.

The present application relates to a kind of knee joint muscle function physiological age assessment characterization method, comprising the following steps: collecting the phenotype parameter of subject, establishes community sample database, and phenotype parameter includes the parameter in four categories of body composition, knee joint muscle function, cognitive function and life habit;Correlation analysis is carried out to each phenotype parameter with actual age, and the candidate phenotype parameter significantly related with age is screened;Based on candidate phenotype parameter, establish knee joint muscle function physiological age model;By calculating multi-domain standardization score, construct radar chart to carry out individual deviation characterization.The physiological age assessment characterization method provided by the present application can simultaneously output physiological age estimation result and multi-dimensional function deviation information, provide systematic technical support for early risk identification, health stratified management, individualized intervention of user, compared with prior art, in evaluation precision, information integrity and application adaptability All have obvious promotion, with good popularization and application prospect.

The invention belongs to the technical field of fermented food, and particularly relates to an application of a ginseng fermentation liquor of phytobacterium plantarum HCS03-001 in an anti-fatigue product. The preparation method comprises the following steps: adding water into ginseng, extracting twice, combining extracting solutions, adding isomaltooligosacharide, and sterilizing to obtain a fermentation substrate; the preparation method comprises the following steps: carrying out activation culture on plant lactobacillus HCS03-001 to obtain an activated bacterium solution, inoculating a fermentation substrate, carrying out fermentation and centrifugation, and sterilizing the supernate to obtain ginseng fermentation liquor, so as to play a remarkable anti-fatigue role by regulating ATP synthesis and lactic acid metabolism in vivo, the composition can be used for accelerating metabolism recovery after exercise, prolonging exhaustive exercise time, improving skeletal muscle tolerance, reducing exercise muscle injury and the like, and can be applied to preparation of exercise nutrition / anti-fatigue food, health care products or medicines, including products for regulating sex hormone metabolism level and promoting protein synthesis and muscle function recovery. The method has the advantages of safety, high efficiency and wide application range.

Disclosed herein are compounds for treating and / or managing muscular dystrophy. According to the embodiment of the invention, the compound can inhibit the activity of DPP-IV, so that the muscle nutrition related protein level in muscles is up-regulated, and the integral improvement of muscle functions is realized. Embodiments herein also result in a composition for upregulating muscle nutrition related protein levels in muscle cells.

The utility model discloses a kind of swallowing function training devices, it is related to medical care technical field, including regulator, the inside of regulator is rotatably connected with two neck pads by bearing, the side of two neck pads is connected with positioning sleeve, the inside of positioning sleeve is slidably connected with support frame, the top of support frame is connected with massage piece, the inside of massage piece is equipped with sliding slot, the inside of sliding slot is slidably connected with sliding block.The utility model has the beneficial effect that: the swallowing function training device, the meshing between the inside gear set of regulator can drive two neck pads to rotate simultaneously, adjust its angle, and fixed in neck, logically, positioning sleeve and support frame can be vertically rotated, make massage piece adhere throat or masseter, carry out muscle massage and swallowing training, and electrode piece is installed on massage rod, adopt low-frequency current stimulation activation or cause muscle contraction, it is favorable to improve muscle function, strengthen swallowing training effect.

The invention discloses a flexible electronic tongue position induction device for children muscle function training, which relates to the technical field of children muscle function training and comprises a flexible substrate, a piezoresistive sensor array integrated on the substrate, a microcontroller, a vibration feedback array and a wireless communication module. The thickness of the flexible substrate is smaller than or equal to 0.5 mm, and the curvature radius is matched with the anatomical form of the hard palate of a child The piezoresistive sensor array is arranged in an 8-row * 6-column matrix, and the unit spacing is 2.5 mm; the vibration feedback array comprises a 5 * 3 micro linear motor, a topological mapping relation is established between the spatial position of the vibration feedback array and the piezoresistive sensor array, the comfort and interestingness of muscle function training of children are improved through the arrangement of the flexible substrate, and mechanical stimulation of traditional hard equipment to oral mucosa of children is eliminated; the problem of asynchronism of tongue position errors and feedback instructions is solved through a topological mapping relation established between the spatial position of the vibration feedback array and the piezoresistive sensor array.

Provided is a composition for preventing, improving, or treating muscular disorders including sulfonamide-based compounds or salts thereof. According to the present disclosure, the sulfonamide-based compounds or salts thereof may prevent inhibition of differentiation of myoblasts by regulating the expression of PHF20 and YY1. Accordingly, since the composition may prevent or alleviate muscle loss, promote muscle regeneration, and improve muscle exercise function, balance ability, and grip strength recovery ability through increased muscles and changes in ratio of muscle fibers, the composition may be effectively used for therapeutic agents, foods, or feeds for preventing, improving or treating muscle disorders, and improving muscle functions or muscle mass.

The application discloses a kind of multi-actuator collaborative targeting control method and system of intelligent waist pad.The method is first based on anatomical static weight and muscle collaborative coupling matrix to calculate muscle function importance score, introduce historical habit and hardware state factor to generate integrated control priority;Subsequently, based on priority, construct trapezoidal motion envelope, according to the score dynamically set gradual time window, execute intermittent unloading cycle containing recovery phase;Finally, through staggered start strategy, air line bus pressure monitoring and mechanical resonance suppression algorithm, the action of multiple actuators is finely scheduled.The application realizes the precise hierarchical intervention to the core and auxiliary muscle groups of waist and back, while ensuring physiological comfort, solves the surge current and air line pressure loss problem caused by multiple load concurrency, improves the electrical safety and mechanical stability of system operation.

The present invention relates to the use of a hemp seed extract for preventing or ameliorating muscle diseases by promoting myoblast differentiation or muscle regeneration. In the present invention, the hemp seed extract may exhibit preventive or therapeutic effects on various muscle diseases by increasing muscle mass, strengthening muscle power, improving muscle function, and enhancing exercise performance, and also has an effect of improving muscle function in healthy individuals in addition to treating muscle diseases.

The invention discloses a wearable muscular function enhancement and muscular index monitoring and analysis system. The system comprises a wearable main body, and an anti-resistance module, a multi-modal data acquisition module, an electrical stimulation module, a control module and a power supply module which are arranged on the wearable main body; wherein the electrical stimulation module is used for activating deep muscle fibers and comprises a flexible electrode group; the multi-modal data acquisition module comprises a plurality of sensors and is used for acquiring multi-dimensional sensing data of a user, and the plurality of sensors are arranged on the wearable main body; the control module is connected with the resistance module, the electrical stimulation module and the multi-modal data acquisition module, and is used for adjusting the electrical stimulation module and the resistance module based on the acquired multi-dimensional sensing data. According to the invention, active resistance and intelligent electrical stimulation functions are integrated, and multi-modal sensing fusion and function integration are carried out, so that monitoring-intervention integration is realized, the collaboration of resistance and electrical stimulation is improved, the monitoring accuracy is ensured, and the portability of the product is also improved due to the compact design.

1. Name of the design product: body measurement instrument (Rossbody cloud 1.0 version). 2. Use of the design product: used for body girth, body shape, metabolism, muscle function evaluation. 3. Design points of the design product: in shape. 4. Picture or photo that best indicates the design points: perspective view. 5. The bottom of the design product is the part that is not easy to see or cannot be seen during use, and the top view is omitted.

The present application relates to the technical field of signal processing, and discloses a muscle tension nerve feedback electric signal data processing method, which comprises preliminary noise reduction, noise suppression, feature extraction, determination of muscle tension baseline and nerve feedback threshold, muscle tension data calculation and correction: a multi-stage noise reduction mode combining sliding average filtering, median filtering and wavelet transform is adopted to effectively remove periodic, pulse and high-frequency noise; the root mean square value and discrete Fourier transform are used to extract features from amplitude and frequency components in multiple dimensions, so as to accurately reflect physiological information such as muscle contraction strength and fatigue state; the muscle tension baseline is determined by collecting individual relaxation state signals, and the nerve feedback threshold is set in combination with subjective feeling, so that the individualization and accuracy of evaluation are enhanced; muscle tension data are calculated in real time, and are dynamically corrected according to energy characteristics of different frequency bands, so that the evaluation result is further optimized, and high-precision and reliable data support is provided for muscle function evaluation and nerve feedback treatment.

The application relates to the technical field of data analysis, and discloses a data analysis method combining muscle synergy analysis and muscle function network, which comprises the following steps: step S1: collecting surface electromyogram signals of each muscle block during movement; step S2: muscle synergy mode analysis, integrating the collected surface electromyogram signal data by using non-negative matrix decomposition, extracting a muscle synergy mode, and quantifying the quality of a reconstruction matrix by using a variance explanation rate; and step S3: muscle function network analysis, obtaining normalized mutual information between each muscle channel as a nonlinear correlation characteristic parameter of multi-channel surface electromyogram, and constructing a muscle function network. The data analysis method of the application combines muscle synergy analysis and muscle function network based on surface electromyogram signals, uses non-negative matrix decomposition for muscle synergy analysis, quantifies the mutual relationship between channels by using normalized mutual information, and constructs a muscle function network, so that potential and valuable structured and modularized information in electromyogram data can be found.

A method for enhancing or improving muscle functions and / or improving athletic performance and / or preventing or relieving fatigue and / or increasing or improving a nitric oxide signal or level, comprising: administering a citrulline dipeptide or a salt, ester, and derivative thereof to a subject.

The present invention relates to a composition for increasing muscle mass, improving muscle function, or preventing or treating muscle disease, comprising Phocaeicola vulgatus or cultures thereof. In addition, the present invention relates to a method for increasing muscle mass, improving muscle function,, or preventing or treating muscular disease, comprising administering or taking a composition comprising Phocaeicola vulgatus or a culture thereof as an active ingredient to an individual in need. The Phocaeicola vulgatus of the present invention has the outstanding effect of increasing muscle strength, increasing muscle weight, and increasing muscle fiber.

The application discloses application of papyriquinone in treatment of muscular dystrophy. The inventors find that papyriquinone can be combined with ERRa, activate ERRa and downstream signal pathways, promote muscle cell differentiation, improve muscle function, promote skeletal muscle regeneration, and finally plays a therapeutic role on Duchenne muscular dystrophy.

The application discloses a brain-muscle function change coupling analysis method based on bidirectional delay compensation, which comprises the following steps: designing an experiment paradigm, collecting signals and pre-processing the signals; determining a bidirectional cortical muscle delay estimation algorithm based on a sliding window and transfer entropy TE, and quantifying the conduction time of the EEG->EMG outgoing path and the EMG->EEG incoming path of the cortical muscle of a test person; performing signal time alignment compensation, calculating the transfer entropy with delay compensation and the average delay compensation transfer entropy, and constructing a directional delay compensation directional cortical muscle connection CMC network based on the transfer entropy with delay compensation and the average delay compensation transfer entropy; extracting evaluation features, and performing brain-muscle function change coupling analysis based on the evaluation features; and the evaluation features are extracted based on the dimensions of the CMC coupling strength, the hemispheric lateralization index and the correlation of the delay-motor function behavior index score based on conduction delay, hemispheric division and task stage. The application also discloses a corresponding system, an electronic device and a computer readable storage medium.