217 results about "Muscle functions" patented technology

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

Disclosed are aqueous formulations comprising urolithins particularly water-based formulations comprising urolithins and maltodextrin. Also disclosed are compositions for admixture with water, methods for the preparation of such aqueous formulations, and to the uses of such formulations for both the treatment of diseases, disorders and conditions, for example, diseases disorders or conditions characterized by inadequate mitochondrial function and for administration to generally healthy individuals for example, for improving health and improving muscle function and performance.

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

The invention discloses a skeletal muscle degeneration chronic disease prediction method and device, equipment and a medium. The method comprises the steps of data preparation and privacy protection; initializing and broadcasting a global model; updating a local model and calculating a weight; an AFA adaptive mechanism is applied; aggregating and updating a global model; performing testing and accuracy evaluation; carrying out iterative training and model optimization; disease prediction and early diagnosis. According to the invention, the accuracy and stability of disease prediction can be effectively improved; through the federated learning technology, the risk of privacy disclosure caused by concentrated data storage in a traditional method is avoided on the premise that the privacy of a patient is protected; besides, in combination with an adaptive aggregation strategy, the problem of data heterogeneity between different medical institutions can be solved, malicious or untrusted updates can be effectively identified and filtered, the precision and reliability of a global model are ensured, and the risk of performance reduction or model failure caused by data inconsistency or malicious clients is avoided.

The invention discloses a biological age assessment method, which comprises the following steps: acquiring a key protein index of a to-be-assessed person, and inputting an improved biological age assessment model I to obtain the biological age of the to-be-assessed person; the improved biological age assessment model I is constructed and obtained based on an elastic network regression algorithm by taking proteome data and body composition age of an individual as training data. The invention also discloses a construction method of the model, namely a two-step method. According to the method, the user is allowed to calculate the biological age according to the proteome data of the user, personalized monitoring of the muscle aging state is achieved, and the method has great guiding significance in the aspects of identifying individuals with premature aging of muscle functions and formulating personalized precise anti-aging schemes.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The invention relates to the technical field of medical rehabilitation equipment, in particular to a surgical postoperative rehabilitation nursing auxiliary device and method based on the Internet of Things, and the device comprises a bearing part, a driving part, a base, a monitoring part and a remote interaction part, the driving part comprises a first driving assembly for providing relative resistance for a using object and a second driving assembly for driving the thigh and the shank to move relatively. The method comprises the steps that in a single training period, the passive muscle activation degree and the active muscle activation degree are determined to determine the rehabilitation degree of the muscle function of a using object; according to the limb movement track and the muscle strength balance condition of the feature movement part, the movement control ability of the using object is determined, and a rehabilitation training scheme of the using object is adjusted according to the rehabilitation degree or the movement control ability. According to the invention, comprehensive monitoring and remote transmission of the rehabilitation process of the use object are realized, and the rehabilitation process can be accurately controlled by medical personnel.

The present invention relates to a composition comprising Lactobacillus gasseri for preventing and treating sarcopenia and, particularly, to: a composition comprising Lactobacillus gasseri BNR17 for preventing, treating or alleviating sarcopenia, a decrease in muscle mass and muscle function, and a decrease in muscular strength and muscular endurance, which are induced by causes such as stress, obesity, aging, drugs, tumors, and the like.

The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for improving muscle functions and application. The nutritional composition for improving the muscle function, provided by the invention, is prepared from the following components in parts by mass: 40 to 60 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride and 20 to 70 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. A specific amount of OPO and OPL are compounded, and the two components have a synergistic effect, so that the exercise amount and the ATP content of an organism are remarkably increased, sarcopenia is relieved by improving energy metabolism, the muscle function is improved, and the food has a wide application prospect in the field of food and is worthy of popularization and application. The food can be used in health-care food, formula food for special medical purposes, infant formula food or special diet food.

The invention discloses an active constant-speed treatment and training method for patients with neurodegenerative diseases and myasthenia, and the method comprises the steps: promoting nerve remodeling through active constant-speed training, enabling the patients to use active constant-speed training equipment, and adjusting the training speed, the angle range and the impedance torque. The device activates a specific muscle group in a safe and controllable environment through an adaptive impedance training technology, gradually enhances training impedance to improve muscle strength, enhances muscle contraction efficiency through targeted training, promotes neural pathway reconstruction and improves nerve-muscle cooperative control ability, and thus achieves neural function recovery and improvement. Therefore, drug therapy provides neuroprotection and muscle function support for a patient, active constant-speed training further promotes the rehabilitation progress through accurate control and real-time feedback, and meanwhile, the flexibility and individuation of training are improved through the multi-mode man-machine interaction and cloud remote guidance functions, so that the rehabilitation effect of the patient is improved. And the treatment effect and life quality of patients with neurodegenerative diseases and myasthenia are improved.

The invention discloses a muscle function rhythm analysis method and system based on unhealthy side cooperation and electronic equipment, and relates to the technical field of data processing. The method comprises the following steps: acquiring an uninjured side electromyographic signal of a patient, and a joint angle signal and a movement track signal of an affected side; based on the electromyographic signal, extracting an uninjured-side cooperative adjustment decline trajectory, and based on the joint angle signal and the motion trajectory signal, extracting an affected-side function take-over response trajectory; identifying a critical point of affected-side function takeover; calculating a first change curvature and a second change curvature, and taking a time point when the first change curvature is greater than the second change curvature for the first time as a motion stability starting point of the affected side; extreme point distribution is extracted, the motion rhythm period of the affected side is determined, and the time length change trend is calculated; and based on the time length change trend, determining a function autonomous maintenance score, and calculating a muscle function rhythm index of the upper limb of the affected side according to the function autonomous maintenance score. By implementing the technical scheme provided by the invention, the accuracy of analyzing the motion data of the limb on the affected side can be improved.

The invention relates to the technical field of medical instruments, in particular to a cerebral apoplexy early rehabilitation robot which comprises a robot body, a mounting plate is mounted on one side of the robot body, a seat is mounted in the mounting plate in a penetrating mode, and a turnover mechanism used for training feet is arranged on one side of the robot body. The top of the robot body is provided with a stretching mechanism used for training the shoulders, the two sides of the seat are provided with massage mechanisms used for massaging the legs, eccentric wheels and the like are driven by a driving motor, foot plates swing left and right in a reciprocating mode, the turning motion of ankle joints is simulated, a guide rod drives a movable plug, and inflation and deflation of an air bag are achieved; in addition, when the massage mechanism works, the stretching and bending mechanism is driven to be matched with the turnover mechanism, multi-dimensional movement of the foot plate is achieved, and functional recovery of ankle joints and foot muscles is promoted.

The invention discloses an application of ganoderma lucidum spore oil in preparation of a medicine or health food for improving sarcopenia. Ganoderma lucidum spore oil can effectively improve weight loss and muscle hypofunction induced by glucocorticoid, and improve the holding power and exercise tolerance level of the body; meanwhile, the skeletal muscle mass and the muscle fiber cross sectional area can be increased, and the skeletal muscle tissue morphological structure is improved; in addition, the ganoderma lucidum spore oil can improve the oxidation resistance of the body and skeletal muscle and reduce the oxidative stress level, so that the skeletal muscle injury related to aging is relieved on the whole. Therefore, the ganoderma lucidum spore oil has a definite application value in the aspect of improving the skeletal muscle function.

Provided are compositions comprising, and methods of administering, gene therapy vectors, particularly recombinant AAV vectors encoding AUF1 proteins for expression in muscle cells for restoring or increasing muscle mass, muscle function or performance, and / or reducing or reversing muscle atrophy. The compositions and methods may be used for the treatment of subject suffering from sarcopenia, muscle degenerative disease or traumatic injury.

The invention belongs to the field of pharmaceutical compositions, and relates to a composition for delaying muscle aging and application thereof. The composition comprises curcumin and milk-derived protein, and can help to delay the problems of muscle atrophy, muscle movement ability decline and the like caused by muscle aging. The composition has both functionality and nutrition, and shows a wide application prospect in the aspects of improving muscle functions and athletic ability.

The invention discloses a composition for preventing and / or treating sarcopenia, which is prepared from the following raw material medicines in parts by weight: 9 to 11 parts of rhizoma polygonati, 7.2 to 8.8 parts of rhizoma dioscoreae, 7.2 to 8.8 parts of folium cortex eucommiae, 9 to 11 parts of fructus mori, 7.2 to 8.8 parts of fructus lycii, 7.2 to 8.8 parts of poria cocos, 9.9 to 12.1 parts of fructus ziziphi jujubae and 7.2 to 8.8 parts of rhizoma curcumae longae. The composition can improve muscle strength, muscle content and muscle function, reduce body fat content, delay senescence process and improve skeletal muscle pathological injury, which indicates that the traditional Chinese medicine composition can be used as a medicine for treating sarcopenia.

The present invention relates to a composition for preventing or treating sarcopenia containing Lactobacillus gasseri, and specifically, to a composition for preventing, treating or improving sarcopenia, reduction of muscle mass and muscle function, and reduction of muscle strength and muscle endurance caused by causes such as stress, obesity, aging, drugs, tumors, etc., containing Lactobacillus gasseri BNR17.

The present invention relates to a use of Cyclo-His Pro (CHP) alone or zinc and Cyclo-His Pro (zinc and CHP, Cycloz) for inhibiting muscle loss or alleviating muscle function decline caused by anti-obesity drugs. More specifically, the present invention provides a pharmaceutical composition and a health functional food composition, which when administered in combination with an anti-obesity drug, exhibit an effect of inhibiting the anti-obesity drug-induced side effect of muscle loss while maintaining a weight loss effect, and exhibit an effect of preventing, alleviating, or treating sarcopenic obesity, and a method for inhibiting muscle loss or alleviating muscle function decline caused by an anti-obesity drug and a method for preventing, alleviating or treating sarcopenic obesity using same.

The present invention is a biarticular forearm support brace comprising a hand wrap, an arm wrap, vibrational motors, and EMG sensors. In the preferred embodiment of the present invention, the present invention further comprises medical-grade materials with elastic properties and a plurality of straps. The present invention takes the tension off the extensor muscles in the forearm by pulling the hand towards the elbow, replacing muscle function and allowing the extensor muscles in the forearm to be shortened while not being contracted.

The present invention relates to a method of improving muscle function in a subject suffering from a disease or condition of impaired muscle function, the method comprising administering to the subject an effective amount of an FGFR3 signaling inhibitor, an NPR-B agonist, or an NPR-C agonist.

It was confirmed that probiotic metabolites of the present invention protect muscle cells and promote differentiation of muscle fibers. In addition, it was confirmed in an animal model of muscle atrophy or sarcopenia induced by dexamethasone that probiotic metabolites increased muscle mass and muscle function, inhibited expression of factors associated with muscle degradation, and increased expression of factors associated with muscle synthesis and regeneration. It was confirmed that probiotic metabolites contribute to alleviation of muscle atrophy by regulating sugar, amino acid, and fatty acid metabolism altered by dexamethasone.

The present invention relates to the field of muscle function assessment based on precise measurement of perioral muscle strength, specifically a device and method for rhythmic training assessment of perioral muscle strength. The method comprises the following steps: 1) collecting the resistance value signal of the perioral muscle strength during training using a thin film pressure sensor; 2) preprocessing the resistance value signal to obtain perioral muscle strength training information for a single movement; 3) calculating the effectiveness of the single training movement; 4) determining whether the training time has reached the overall training time; if so, executing step 5); otherwise, repeating steps 1) to 3); and 5) comprehensively evaluating the training movements throughout the entire training process and outputting an evaluation score for this training session. The present invention employs automated analysis methods to evaluate each training movement in real time and output the overall training effectiveness results.

The invention discloses lactobacillus delbrueckii with a muscle protection function in a fat reducing period as well as a product and application thereof, belongs to the technical field of microorganisms, and discloses lactobacillus delbrueckii subsp. Lactis Turb8 with the preservation number of CGMCC No.35627. The lactobacillus delbrueckii subsp. Lactis Turb8 has the advantages that the preservation number is CGMCC No.35627; the strain or the preparation thereof can effectively prevent or improve the accompanying problems of muscle loss and function decline in the process of applying fat-reducing drugs such as GLP-1 receptor agonists (such as liraglutide and semeglutide), and the effect of reducing fat but not reducing muscle is achieved. The strain disclosed by the invention can be used for remarkably increasing the lean body mass ratio of a user, increasing the muscle mass of lower limbs, increasing the cross sectional area of muscle fibers and improving muscle function indexes such as strength of four limbs and suspension endurance while keeping the original weight-reducing effect of a fat-reducing medicine. The invention also relates to microbial agents comprising this strain, various preparations, their use in the preparation of products for ameliorating (in particular drug-induced) muscle reduction.

The invention discloses a BCI method and system based on EOG autonomous rehabilitation, and the method comprises the steps: constructing a graphical user interface comprising button flickering visual clues and corresponding upper limb motion types, enabling all buttons to flicker circularly according to a set time interval, and enabling a user to select a target motion function through synchronous blinking and then stop flickering; the method comprises the following steps: acquiring an EOG signal when a user blinking through a wearable BCI device, and synchronously marking a motion type corresponding to button flickering to form motion intention information; a decision control unit is optimized based on the threshold parameter obtained in the calibration stage, EOG signal features are extracted by using the optimized decision control unit, and a blinking event corresponding to button blinking is detected; a target button function is recognized according to the blink detection result, and a control instruction corresponding to upper limb rehabilitation exercise is generated and sent to the lower computer; the lower computer receives the instruction, drives the motor to execute rehabilitation actions, and assists the user in completing upper limb joint and muscle function training.

The invention relates to the technical field of biological medicine, in particular to an oligonucleotide molecule for inhibiting expression of ACTRIIB and application of the oligonucleotide molecule. The oligonucleotide molecule comprises at least 12 contiguous nucleotides of any one of the nucleotide sequences of SEQ ID NO: 1 to SEQ ID NO: 70, SEQ ID NO: 141 to SEQ ID NO: 185, SEQ ID NO: 231 to SEQ ID NO: 244 and SEQ ID NO: 71 to SEQ ID NO: 140, SEQ ID NO: 186 to SEQ ID NO: 230, SEQ ID NO: 245 to SEQ ID NO: 258, or a sequence that differs from the at least 12 contiguous nucleotides by no more than 3 nucleotides, or a sequence complementary thereto, the nucleotides being in a modified or unmodified state. The oligonucleotide molecule mediates RNA interference on the ACTRIIB, so that muscle building, muscle function improvement, exercise capability enhancement and prevention or treatment of muscle system related diseases are realized.

The invention provides a peripheral facial paralysis rehabilitation device. The peripheral facial paralysis rehabilitation device comprises a host and at least one stimulation patch electrically connected with the host, the stimulation patch is prefabricated into a special-shaped geometric structure matched with the anatomical direction of facial muscles, and at least integrates a myoelectricity acquisition part, an electrical stimulation part and a heating part; the host is configured to collect a surface electromyographic signal sequence of a user under a specified facial action through the electromyographic collection part of the worn stimulation patch, and the stimulation patch worn by the user is in one-to-one correspondence with target facial muscles involved in the specified facial action; determining at least one muscle function state index according to the surface electromyogram signal sequence; determining a working mode according to the muscle function state index; and controlling the electrical stimulation part and / or the heating part of the stimulation patch worn by the user to work according to the working parameters corresponding to the determined working mode.

The portable controllable suspension vibrator for rehabilitation is installed on a rope of a suspension instrument and comprises a shell, a vibration motor and two vibration plates, the vibration motor is arranged in the shell, and the two vibration plates are symmetrically arranged at the two ends of the shell and extend in the length direction of the shell; the front end faces of the two vibration plates are each provided with a connecting piece, and the two connecting pieces are symmetrically arranged and detachably connected with the corresponding ropes. According to the utility model, the suspension apparatus of the rehabilitation training device is connected with the vibrating plate through the rope, the vibrating plate is vibrated through the vibrating motor, and the vibration is transmitted to a patient on the rehabilitation training device through the rope, so that the patient is subjected to vibration treatment, and the rehabilitation training device is used for assisting in treating neuromuscular diseases, relieving pain, activating muscle functions and the like. The device is externally connected to the rehabilitation training device and can be adjusted according to the requirements of a patient, the structure of an original rehabilitation training device does not need to be changed, installation is convenient, and cost is low.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.