178 results about "Muscle functions" patented technology

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

The invention discloses a skeletal muscle degeneration chronic disease prediction method and device, equipment and a medium. The method comprises the steps of data preparation and privacy protection; initializing and broadcasting a global model; updating a local model and calculating a weight; an AFA adaptive mechanism is applied; aggregating and updating a global model; performing testing and accuracy evaluation; carrying out iterative training and model optimization; disease prediction and early diagnosis. According to the invention, the accuracy and stability of disease prediction can be effectively improved; through the federated learning technology, the risk of privacy disclosure caused by concentrated data storage in a traditional method is avoided on the premise that the privacy of a patient is protected; besides, in combination with an adaptive aggregation strategy, the problem of data heterogeneity between different medical institutions can be solved, malicious or untrusted updates can be effectively identified and filtered, the precision and reliability of a global model are ensured, and the risk of performance reduction or model failure caused by data inconsistency or malicious clients is avoided.

The invention discloses a biological age assessment method, which comprises the following steps: acquiring a key protein index of a to-be-assessed person, and inputting an improved biological age assessment model I to obtain the biological age of the to-be-assessed person; the improved biological age assessment model I is constructed and obtained based on an elastic network regression algorithm by taking proteome data and body composition age of an individual as training data. The invention also discloses a construction method of the model, namely a two-step method. According to the method, the user is allowed to calculate the biological age according to the proteome data of the user, personalized monitoring of the muscle aging state is achieved, and the method has great guiding significance in the aspects of identifying individuals with premature aging of muscle functions and formulating personalized precise anti-aging schemes.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for improving muscle functions and application. The nutritional composition for improving the muscle function, provided by the invention, is prepared from the following components in parts by mass: 40 to 60 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride and 20 to 70 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. A specific amount of OPO and OPL are compounded, and the two components have a synergistic effect, so that the exercise amount and the ATP content of an organism are remarkably increased, sarcopenia is relieved by improving energy metabolism, the muscle function is improved, and the food has a wide application prospect in the field of food and is worthy of popularization and application. The food can be used in health-care food, formula food for special medical purposes, infant formula food or special diet food.

The invention discloses an active constant-speed treatment and training method for patients with neurodegenerative diseases and myasthenia, and the method comprises the steps: promoting nerve remodeling through active constant-speed training, enabling the patients to use active constant-speed training equipment, and adjusting the training speed, the angle range and the impedance torque. The device activates a specific muscle group in a safe and controllable environment through an adaptive impedance training technology, gradually enhances training impedance to improve muscle strength, enhances muscle contraction efficiency through targeted training, promotes neural pathway reconstruction and improves nerve-muscle cooperative control ability, and thus achieves neural function recovery and improvement. Therefore, drug therapy provides neuroprotection and muscle function support for a patient, active constant-speed training further promotes the rehabilitation progress through accurate control and real-time feedback, and meanwhile, the flexibility and individuation of training are improved through the multi-mode man-machine interaction and cloud remote guidance functions, so that the rehabilitation effect of the patient is improved. And the treatment effect and life quality of patients with neurodegenerative diseases and myasthenia are improved.

The invention discloses a muscle function rhythm analysis method and system based on unhealthy side cooperation and electronic equipment, and relates to the technical field of data processing. The method comprises the following steps: acquiring an uninjured side electromyographic signal of a patient, and a joint angle signal and a movement track signal of an affected side; based on the electromyographic signal, extracting an uninjured-side cooperative adjustment decline trajectory, and based on the joint angle signal and the motion trajectory signal, extracting an affected-side function take-over response trajectory; identifying a critical point of affected-side function takeover; calculating a first change curvature and a second change curvature, and taking a time point when the first change curvature is greater than the second change curvature for the first time as a motion stability starting point of the affected side; extreme point distribution is extracted, the motion rhythm period of the affected side is determined, and the time length change trend is calculated; and based on the time length change trend, determining a function autonomous maintenance score, and calculating a muscle function rhythm index of the upper limb of the affected side according to the function autonomous maintenance score. By implementing the technical scheme provided by the invention, the accuracy of analyzing the motion data of the limb on the affected side can be improved.

The invention discloses an application of ganoderma lucidum spore oil in preparation of a medicine or health food for improving sarcopenia. Ganoderma lucidum spore oil can effectively improve weight loss and muscle hypofunction induced by glucocorticoid, and improve the holding power and exercise tolerance level of the body; meanwhile, the skeletal muscle mass and the muscle fiber cross sectional area can be increased, and the skeletal muscle tissue morphological structure is improved; in addition, the ganoderma lucidum spore oil can improve the oxidation resistance of the body and skeletal muscle and reduce the oxidative stress level, so that the skeletal muscle injury related to aging is relieved on the whole. Therefore, the ganoderma lucidum spore oil has a definite application value in the aspect of improving the skeletal muscle function.

Provided are compositions comprising, and methods of administering, gene therapy vectors, particularly recombinant AAV vectors encoding AUF1 proteins for expression in muscle cells for restoring or increasing muscle mass, muscle function or performance, and / or reducing or reversing muscle atrophy. The compositions and methods may be used for the treatment of subject suffering from sarcopenia, muscle degenerative disease or traumatic injury.

The invention belongs to the field of pharmaceutical compositions, and relates to a composition for delaying muscle aging and application thereof. The composition comprises curcumin and milk-derived protein, and can help to delay the problems of muscle atrophy, muscle movement ability decline and the like caused by muscle aging. The composition has both functionality and nutrition, and shows a wide application prospect in the aspects of improving muscle functions and athletic ability.

The present invention relates to a composition for preventing or treating sarcopenia containing Lactobacillus gasseri, and specifically, to a composition for preventing, treating or improving sarcopenia, reduction of muscle mass and muscle function, and reduction of muscle strength and muscle endurance caused by causes such as stress, obesity, aging, drugs, tumors, etc., containing Lactobacillus gasseri BNR17.

The present invention relates to a use of Cyclo-His Pro (CHP) alone or zinc and Cyclo-His Pro (zinc and CHP, Cycloz) for inhibiting muscle loss or alleviating muscle function decline caused by anti-obesity drugs. More specifically, the present invention provides a pharmaceutical composition and a health functional food composition, which when administered in combination with an anti-obesity drug, exhibit an effect of inhibiting the anti-obesity drug-induced side effect of muscle loss while maintaining a weight loss effect, and exhibit an effect of preventing, alleviating, or treating sarcopenic obesity, and a method for inhibiting muscle loss or alleviating muscle function decline caused by an anti-obesity drug and a method for preventing, alleviating or treating sarcopenic obesity using same.

The present invention is a biarticular forearm support brace comprising a hand wrap, an arm wrap, vibrational motors, and EMG sensors. In the preferred embodiment of the present invention, the present invention further comprises medical-grade materials with elastic properties and a plurality of straps. The present invention takes the tension off the extensor muscles in the forearm by pulling the hand towards the elbow, replacing muscle function and allowing the extensor muscles in the forearm to be shortened while not being contracted.

The present invention relates to a method of improving muscle function in a subject suffering from a disease or condition of impaired muscle function, the method comprising administering to the subject an effective amount of an FGFR3 signaling inhibitor, an NPR-B agonist, or an NPR-C agonist.

It was confirmed that probiotic metabolites of the present invention protect muscle cells and promote differentiation of muscle fibers. In addition, it was confirmed in an animal model of muscle atrophy or sarcopenia induced by dexamethasone that probiotic metabolites increased muscle mass and muscle function, inhibited expression of factors associated with muscle degradation, and increased expression of factors associated with muscle synthesis and regeneration. It was confirmed that probiotic metabolites contribute to alleviation of muscle atrophy by regulating sugar, amino acid, and fatty acid metabolism altered by dexamethasone.

The present invention relates to the field of muscle function assessment based on precise measurement of perioral muscle strength, specifically a device and method for rhythmic training assessment of perioral muscle strength. The method comprises the following steps: 1) collecting the resistance value signal of the perioral muscle strength during training using a thin film pressure sensor; 2) preprocessing the resistance value signal to obtain perioral muscle strength training information for a single movement; 3) calculating the effectiveness of the single training movement; 4) determining whether the training time has reached the overall training time; if so, executing step 5); otherwise, repeating steps 1) to 3); and 5) comprehensively evaluating the training movements throughout the entire training process and outputting an evaluation score for this training session. The present invention employs automated analysis methods to evaluate each training movement in real time and output the overall training effectiveness results.

The invention discloses lactobacillus delbrueckii with a muscle protection function in a fat reducing period as well as a product and application thereof, belongs to the technical field of microorganisms, and discloses lactobacillus delbrueckii subsp. Lactis Turb8 with the preservation number of CGMCC No.35627. The lactobacillus delbrueckii subsp. Lactis Turb8 has the advantages that the preservation number is CGMCC No.35627; the strain or the preparation thereof can effectively prevent or improve the accompanying problems of muscle loss and function decline in the process of applying fat-reducing drugs such as GLP-1 receptor agonists (such as liraglutide and semeglutide), and the effect of reducing fat but not reducing muscle is achieved. The strain disclosed by the invention can be used for remarkably increasing the lean body mass ratio of a user, increasing the muscle mass of lower limbs, increasing the cross sectional area of muscle fibers and improving muscle function indexes such as strength of four limbs and suspension endurance while keeping the original weight-reducing effect of a fat-reducing medicine. The invention also relates to microbial agents comprising this strain, various preparations, their use in the preparation of products for ameliorating (in particular drug-induced) muscle reduction.

The invention discloses a BCI method and system based on EOG autonomous rehabilitation, and the method comprises the steps: constructing a graphical user interface comprising button flickering visual clues and corresponding upper limb motion types, enabling all buttons to flicker circularly according to a set time interval, and enabling a user to select a target motion function through synchronous blinking and then stop flickering; the method comprises the following steps: acquiring an EOG signal when a user blinking through a wearable BCI device, and synchronously marking a motion type corresponding to button flickering to form motion intention information; a decision control unit is optimized based on the threshold parameter obtained in the calibration stage, EOG signal features are extracted by using the optimized decision control unit, and a blinking event corresponding to button blinking is detected; a target button function is recognized according to the blink detection result, and a control instruction corresponding to upper limb rehabilitation exercise is generated and sent to the lower computer; the lower computer receives the instruction, drives the motor to execute rehabilitation actions, and assists the user in completing upper limb joint and muscle function training.

The invention relates to the technical field of biological medicine, in particular to an oligonucleotide molecule for inhibiting expression of ACTRIIB and application of the oligonucleotide molecule. The oligonucleotide molecule comprises at least 12 contiguous nucleotides of any one of the nucleotide sequences of SEQ ID NO: 1 to SEQ ID NO: 70, SEQ ID NO: 141 to SEQ ID NO: 185, SEQ ID NO: 231 to SEQ ID NO: 244 and SEQ ID NO: 71 to SEQ ID NO: 140, SEQ ID NO: 186 to SEQ ID NO: 230, SEQ ID NO: 245 to SEQ ID NO: 258, or a sequence that differs from the at least 12 contiguous nucleotides by no more than 3 nucleotides, or a sequence complementary thereto, the nucleotides being in a modified or unmodified state. The oligonucleotide molecule mediates RNA interference on the ACTRIIB, so that muscle building, muscle function improvement, exercise capability enhancement and prevention or treatment of muscle system related diseases are realized.

The invention provides a peripheral facial paralysis rehabilitation device. The peripheral facial paralysis rehabilitation device comprises a host and at least one stimulation patch electrically connected with the host, the stimulation patch is prefabricated into a special-shaped geometric structure matched with the anatomical direction of facial muscles, and at least integrates a myoelectricity acquisition part, an electrical stimulation part and a heating part; the host is configured to collect a surface electromyographic signal sequence of a user under a specified facial action through the electromyographic collection part of the worn stimulation patch, and the stimulation patch worn by the user is in one-to-one correspondence with target facial muscles involved in the specified facial action; determining at least one muscle function state index according to the surface electromyogram signal sequence; determining a working mode according to the muscle function state index; and controlling the electrical stimulation part and / or the heating part of the stimulation patch worn by the user to work according to the working parameters corresponding to the determined working mode.

The portable controllable suspension vibrator for rehabilitation is installed on a rope of a suspension instrument and comprises a shell, a vibration motor and two vibration plates, the vibration motor is arranged in the shell, and the two vibration plates are symmetrically arranged at the two ends of the shell and extend in the length direction of the shell; the front end faces of the two vibration plates are each provided with a connecting piece, and the two connecting pieces are symmetrically arranged and detachably connected with the corresponding ropes. According to the utility model, the suspension apparatus of the rehabilitation training device is connected with the vibrating plate through the rope, the vibrating plate is vibrated through the vibrating motor, and the vibration is transmitted to a patient on the rehabilitation training device through the rope, so that the patient is subjected to vibration treatment, and the rehabilitation training device is used for assisting in treating neuromuscular diseases, relieving pain, activating muscle functions and the like. The device is externally connected to the rehabilitation training device and can be adjusted according to the requirements of a patient, the structure of an original rehabilitation training device does not need to be changed, installation is convenient, and cost is low.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

The present application belongs to the field of nutritional biotechnology, in particular, the present application relates to an anti-aging composition and its application. Through a large number of research and screening, it is found that the combination of specific grape seed extract, ergothioneine and specific black ginger extract can exert the synergistic effect of the three, fully exert the grape seed extract (antioxidant, free radical scavenging), black ginger (testosterone enhancement, muscle function enhancement), ergothioneine (protection of mitochondria and lysosome), form a multi-pathway mechanism, multi-level improvement of aging, improvement of fertility and muscle capacity.

A muscle function preservation type total temporomandibular joint prosthesis includes an articular fossa member (1) and an articular head member (2) abutting against the articular fossa member (1). The articular head member (2) includes a mandibular trailing edge fixing plate (21), a sigmoid notch fixing plate (22) and an articular head portion (23). The mandibular trailing edge fixing plate (21) is connected to a bottom end of the articular head portion (23) and extends downwards, and has a plate-shaped structure and includes a mandibular-trailing-edge-surface attaching surface. The sigmoid notch fixing plate (22) protrudes from one side of the mandibular trailing edge fixing plate (21) and extends in a direction away from the mandibular trailing edge fixing plate (21), and has a plate-shaped structure and includes a mandibular-ramus-proximal-sigmoid-notch-portion attaching surface.

The present invention is focused on extending the lifespan and the healthy period of life (healthspan), delaying the development of chronic diseases and dysfunctions, which is a growing need of aging societies. Among the strategies to promote and extend healthspan, nutrition and food ingredients play a central role. The present invention is related to standardized delphinidin-rich maqui berry composition comprising different amounts and combination of delphinidins, which represent a potent class of antioxidant anthocyanins as agent for reducing progressive loss of skeletal muscle, increasing muscle mass and anti-aging agent or geroprotective agent, and thereby, enhancing the healthspan and preserving locomotive functions for longer periods of life. Such effect was measured as climbing ability during life time in an animal model (Drosophila melanogaster), Experimental assays demonstrated that delphinidin-rich standardized maqui berry extracts upregulate the expression of antioxidant enzymes and mitochondrial homeostasis-related proteins, which determine contractile muscle function. Such delphinidin-rich standardized maqui berry composition is useful as antioxidant supplement for adults and elderly.

The present invention relates to methods of improving muscle function in a subject suffering from a disease or condition in which muscle function is impaired, the method comprising administering an effective amount of, an inhibitor of FGFR3 signaling, an NPR-B agonist or an NPR-C agonist to said subject.

The present invention discloses a video-based muscle contraction measurement and facial muscle synergy analysis system, which includes a data acquisition module, a data processing module, a muscle contraction signal extraction module, a facial muscle synergy analysis module and a comprehensive analysis module. The video-based muscle contraction measurement method extracts muscle contraction strength and direction information through video. In the normal feature entry stage of facial muscle synergy analysis, the synergy feature vectors of the normal user group are stored in a local server, and the standard feature ranges in different modes are obtained as a basis for judging whether the muscle synergy function is normal or abnormal. In the detection stage, the user's synergy feature vector is extracted and compared with the synergy feature vector in the local server. The facial synergy analysis is used to determine whether the current muscle function is normal, and the position of the pathological muscle is located according to the direction of the synergy feature vector.

The invention discloses a cortex and muscle coupling analysis method based on information flow decomposition. The method comprises the following steps: collecting and pre-processing EEG signals and EMG signals of multiple channels; constructing a cortical muscle function connection network through an ordinal number division conversion method; using a Helmholtz-Hough-Ketaria decomposition method to decompose and remove a circulating flow in the cortex muscle function connection network to obtain a residual gradient flow network; analyzing and comparing topological characteristics of the cortex muscle function connection network and the gradient flow network by using node access intensity; performing causal hierarchy analysis on the gradient flow network; the node input intensity and the causal hierarchy are used as classification features, and a support vector machine is used as a classifier for classification. According to the method, a high-credibility cortical muscle function connection network is constructed through an ordinal number division conversion network, the network is decoupled into a circulation flow and a gradient flow through Helmholtz-Hough-Cotela decomposition, and finally, the information transmission and causal relationship in a cortical muscle coupling system is intuitively reflected by utilizing causal hierarchical division.

Disclosed is a traditional Chinese medicine composition for preventing and / or treating sarcopenia. The traditional Chinese medicine composition comprises, in parts by weight, 9-11 parts of Citri Reticulatae Pericarpium, 9-11 parts of Achyranthis Bidentatae Radix, 9-11 parts of Hordei Germinatus Fructus, 9-11 parts of Drynariae Rhizoma, 9-11 parts of Eucommiae Cortex, 9-11 parts of Lycii Fructus, 13.5-16.5 parts of Astragali Radix, and 13.5-16.5 parts of Cibotii Rhizoma. The traditional Chinese medicine composition in the present invention can improve the muscle strength, muscle mass and muscle functions, reduce the body fat mass, and delay the aging process, and has no significant influence on the food intake, suggesting that the traditional Chinese medicine composition can be used as a medicine for treating sarcopenia.