62 results about "Neural function" patented technology

Methods of using tetanus toxin to modulate or control neural functions or nonneural cellular activities at selected sites in animals, particularly in mammals, and more particularly in humans, are provided. Pharmaceutical formulations to modulate neural functions or non-neural cellular activities of an animal at selected sites in animals, particularly in mammals, and more particularly in humans are also provided. Uses of tetanus toxin in preparation of medicaments for methods of treating clinical disorders or symptoms of animals, particularly mammals and more particularly humans are also provided.

Methods of using tetanus toxin to modulate or control neural functions or normeural cellular activities at selected sites in animals, particularly in mammals, and more particularly in humans, are provided. Pharmaceutical formulations to modulate neural functions or non-neural cellular activities of an animal at selected sites in animals, particularly in mammals, and more particularly in humans are also provided. Uses of tetanus toxin in preparation of medicaments for methods of treating clinical disorders or symptoms of animals, particularly mammals and more particularly humans are also provided.

A method and a device for non-invasive blood pressure measurement wherein the angle between the hand and the wrist, and the turning angle of the wrist relative to the middle part of the forearm, are kept to the most suitable degree for measuring the blood pressure of the radial artery. At least one pressure bladder and one arterial pulse transducer array are placed on the skin over the radial artery of the wrist to apply the external pressure to the artery and to detect the change of the arterial pulse signals. This method and device can correctly measure the intermittent or continuous blood pressure of the radial artery or the ulnar artery based on the principles of oscillation method and volume compensation method, and effectively eliminate the influence on the measurement due to body movement and the influence on blood circulation and neural function of the hand caused by long-term blood pressure measurement.

A pharmaceutical for prevention and treatment of demyelination-associated neural function impairing diseases contains erythropoietin as an active ingredient, and protectively act on the survival of oligodendrocytes, which form a myelin sheath, in cerebrovascular dementia typified by multiple sclerosis and Binswanger disease, diseases involving demyelination. The pharmaceutical and method also promote maturation of undifferentiated oligodendrocytes present in the brain, activating remyelination. Through these mechanisms, the pharmaceutical and method can prevent and treat demyelination-associated neural function impairing diseases.

A method and apparatus for monitoring optic function is provided. The apparatus and method relies on two principle modes of measuring the function of the optic nerve, namely, monitoring VEPs for neural function, and monitoring at least one additional parameter of optic function such as intraocular pressure, blood flow or location of the eye to provide a multi-variable optic function monitor. The method and apparatus is proposed for the use to diagnose and potentially prevent the incidence of POVL and anaesthesia awareness in patients during medical procedures.

Assessment of one of the sensory nervous systems of a human subject using patterns of null and non-null stimuli. Parts of the visual system for example, are presented with two simultaneous sequences of stimuli. Each sequence is varied over time between a null stimulus and one or more less frequent non-null stimuli. The variation of each sequence is also controlled so that neighbouring parts of the sensory system are less likely to receive simultaneous non-null stimuli. The stimuli are therefore sparse both in time and in some other aspect, typically a spatial dimension. One or more responses of the subject are measured and weight functions are determined for assessment of the sensory system.

Fitting systems and fitting methods for prostheses are provided. An instrumented prosthesis (IP), such as an instrumented prosthetic hand (IPH), can include sensors and can be connected to a neural stimulation system (NSS) or neural recording system (NRS), which includes an implanted system having electrodes. The NSS / NRS can also be connected to a software module, which can assist in calibrating the electrodes and mapping sensor values to stimulation parameters and / or mapping motor intent from recorded neural activity to control of prostheses.

Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.

The invention discloses a traditional Chinese medicine combination, which is formed by raw medicines according to the proportion by weight as follows: ginseng or ginseng cauline leaf is 1 to 15 parts, and erigeron is 5 to 30 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc.; more particularly, for the improved aspect to the neurological symptom, the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance. The invention further discloses a preparation method of the traditional Chinese medicine combination and the pharmaceutical application.

The invention relates to application of a salvianolic acid A composition in preparing medicines for improving neural function symptom after cerebral ischemia. The composition is prepared from the following components in percentage by weight: 90-99% of salvianolic acid A, 0.1-3% of alkannic acid, 0.1-3% of rosmarinic acid, 0.1-3% of salvianolic acid B and 0.1-5% of salvianolic acid C.

The invention provides a neural electrode with high charge injection efficiency and good biocompatibility. The neural electrode comprises a current generating device, a first electrode and a second electrode, wherein the current generating device is connected with the first electrode and the second electrode through conductive metal wires; at least one of the first electrode and the second electrode is a graphene electrode; the graphene electrode is a three-dimensional porous graphene electrode, is soft in texture and good in stability, and can bear repeated pressing and folding; the neural electrode has extremely high charge injection efficiency, is used for electrically stimulating tissues and organs such as a heart and nerve, and can be used for promoting electrical stimulation recovery of nerve cells and further promoting recovery of neural function; the neural electrode is good in biocompatibility and good in stability in vivo; the nerve cells can be cultured on the surface of the neural electrode and are high in survival rate.

The invention discloses a drug combination, which is mainly formed by traditional Chinese medicine extracts according to the proportion by weight as follows: the total saponin extract of ginseng or ginseng cauline leaf is 1 to 20 parts, the total flavone extract of erigeron is 1 to 20 parts, and the total caffeic acid ester of the erigeron is 1 to 20 parts. Adopting the conventional traditional Chinese medicine combination formula, the drug combination has obvious neuroprotective effect and neural function improving, etc, by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the drug combination can effectively block most pathological mechanisms of a plurality of disease nerve injuries such as ischemic cerebrovascular disease; particularly, in the aspect of improving the neurological symptom, the traditional Chinese medicine injection is helpful to enhance the living quality of the patient, achieves the purpose of improving prognosis, and has important clinical application significance. The invention futher discloses the pharmaceutical application of the drug combination.

The invention discloses a medicinal composition for treating dizziness, headache, neural headache and migraine caused by cerebral thrombosis, hypertension, cerebral arteriosclerosis, cervical spondylosis and the like and a preparation method thereof. The medicinal composition is prepared from the following raw materials in part by mass: 20 to 180 parts of kudzuvine root, 10 to 70 parts of Szechuan lovage rhizome, 10 to 50 parts of gambir plant and 10 to 70 parts of root of red-rooted salvia. The method for the medicinal composition comprises the following steps of: decocting the raw materials for preparing the medicinal composition by adding water, extracting the decoction, collecting filtrate, concentrating the filtrate to obtain thin paste, adding 60 to 90 percent ethanol into the thin paste so that the ethanol content reaches 30 to 60 percent, standing the mixture, taking supernate and reclaiming all ethanol to obtain thick paste, drying the thick paste, crushing the dried thick paste to obtain powder, and preparing the powder into capsules or tablets and the like. Clinical experiments show that the medicinal composition has the effects of activating blood, dissolving stasis and dredging the channel, and is used for treating dizziness, headache, neural headache and migraine caused by cerebral thrombosis, hypertension, cerebral arteriosclerosis, cervical spondylosis and the like. The medicinal composition can improve cerebral ischemia and cerebral blood supply insufficiency, is favorable for recovery of neural function, enhances the memory, and can improve the blood circulation of the lower limb and enhance the activity of the lower limb.

Assessment of one of the sensory nervous systems of a human subject using patterns of null and non-null stimuli. Parts of the visual system for example, are presented with two simultaneous sequences of stimuli. Each sequence is varied over time between a null stimulus and one or more less frequent non-null stimuli. The variation of each sequence is also controlled so that neighboring parts of the sensory system are less likely to receive simultaneous non-null stimuli. The stimuli are therefore sparse both in time and in some other aspect, typically a spatial dimension. One or more responses of the subject are measured and weight functions are determined for assessment of the sensory system.

The invention provides a protein with a similar function of an irisin structural domain. The protein is a brand-new protein, is simple in structure, convenient to obtain, and is capable of rapidly carrying out mutation transformation. An experiment proves that the protein has similar characteristic of the irisin structural domain, and is capable of transforming white fat in a body into brown fat to cause energy consumption and immunity enhancement, so that a new effective way is provided for prevention or treatment of diseases or states caused by excessive energy intake / storage; the protein has the major performances that white fat accumulation in the body is reduced; the blood glucose and insulin level is regulated and balanced; the pressure of the organism is relieved, so as to reach the efficacy of treating obesity; hypomnesia caused by senile and organic neural function degradation is improved; the memory ability is improved; the energy storage level in the body is reduced; the telomere shortening speed is retarded, so as to retard organism ageing. The protein provided by the invention has safe and efficient favorable conditions on regulation of a natural signal channel.

The invention discloses a pharmaceutical composition of cefdinir and its medical application. The pharmaceutical composition of cefdinir provided by the invention contains cefdinir and a novel natural product compound (I), cefdinir Compound (Ⅰ) can significantly improve the neurological function scores of rats with cerebral ischemia-reperfusion and significantly reduce the expression levels of inflammatory cytokines TNF-α, IL-1β and adhesion molecules VCAM-1 and ICAM-1. The combined effect is better than single use, and can be developed into a drug for protecting cerebral ischemia-reperfusion injury.

The invention discloses a traditional Chinese medicine injection, which mainly makes a squirt cut by a traditional Chinese medicine extract according to the proportion by weight as follows: the total saponin extract of ginseng or ginseng cauline leaf is 1 to 20 parts, the total flavone extract of erigeron is 1 to 20 parts, and the total caffeic acid ester of the erigeron is 1 to 20 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc. More particularly, for the improved aspect to the neurological symptom, the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance. The invention further discloses a preparation method of the traditional Chinese medicine injection and the pharmaceutical application.

A method for creating a dynamic neural function library that relates to Artificial Intelligence systems and devices is provided. Within a dynamic neural network (artificial intelligent device), a plurality of control values are autonomously generated during a learning process and thus stored in synaptic registers of the artificial intelligent device that represent a training model of a task or a function learned by the artificial intelligent device. Control Values include, but are not limited to, values that indicate the neurotransmitter level that is present in the synapse, the neurotransmitter type, the connectome, the neuromodulator sensitivity, and other synaptic, dendric delay and axonal delay parameters. These values form collectively a training model. Training models are stored in the dynamic neural function library of the artificial intelligent device. The artificial intelligent device copies the function library to an electronic data processing device memory that is reusable to train another artificial intelligent device.

The invention relates to a cell growth and / or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and / or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals. Further, the invention relates to antibodies against the peptides, inter alia for diagnostic use, for example, the diagnosis of stress-induced male infertility. The invention also relates to in vitro and in vivo methods for screening of drugs that affect the central nervous system, and are potential modulators of interactions between the “readthrough” form of acetylcholinesterase, AChE-R, the intracellular receptor RACK1 and the kinase PKC.

The invention discloses an integrated eye and brain visual function imaging system. The system includes: a visual stimulus presentation device which presents pictures and videos comprising a plurality of stimulus-inducing patterns; an eye vision imaging device which is a retina and pupil imaging device based on multi-spectrum; a brain vision imaging device which is a visual cortex blood flow signal imaging device based on a spectrum technology related to near infrared diffusion; and a cooperative working station which comprises an imaging acquisition control module and an image analysis module and is used for cooperatively controlling the eye vision imaging device and the brain vision imaging device and processing and analyzing the acquired multispectral retina and pupil images and visual cortex blood flow images. The system can realize synchronous recording of nerve function response of eye retina, pupil and brain visual cortex, carry out joint analysis on multi-mode multi-parameter visual physiological signals, and provide a method for visual information coding and decoding, visual reconstruction mechanism research, visual nerve regulation and quantitative evaluation damage positioning and the like.

A method for creating a dynamic neural function library that relates to Artificial Intelligence systems and devices is provided. Within a dynamic neural network (artificial intelligent device), a plurality of control values are autonomously generated during a learning process and thus stored in synaptic registers of the artificial intelligent device that represent a training model of a task or a function learned by the artificial intelligent device. Control Values include, but are not limited to, values that indicate the neurotransmitter level that is present in the synapse, the neurotransmitter type, the connectome, the neuromodulator sensitivity, and other synaptic, dendric delay and axonal delay parameters. These values form collectively a training model. Training models are stored in the dynamic neural function library of the artificial intelligent device. The artificial intelligent device copies the function library to an electronic data processing device memory that is reusable to train another artificial intelligent device.

The invention provides a heat-resistant, antibacterial and sun-proof camellia flower nanometer microcapsule with long-term slow release effect and a preparation method thereof. An essence capsule is characterized in that camellia flower oil is used as a core material, titanium dioxide and silicon dioxide are used as wall materials, and a sol-gel-spraying reaction method is adopted to prepare the heat-resistant, antibacterial and sun-proof camellia flower nanometer microcapsule with long-term slow release effect by one step. The essence capsule has the characteristics that the heat-resistant property is good, the antibacterial, sun-proof and weather-resistant properties are realized, the poison is avoided, the agglomeration amount is small, the content of impurities is low, and the re-dispersing processing is easy; the medical effects of clearing heat and dehumidification, dispelling wind and relieving itching, killing insects and detoxifying, clearing stomach and moistening intestines,restringing and nourishing skin, eliminating swelling and relieving pain, promoting eyesight and brightening hairs, enhancing elasticity and toughness of blood vessels, delaying atherosclerosis, enhancing intestine and stomach absorption function, promoting hormone excretion of endocrine glands, preventing degrading of neural functions, enhancing immunity of a human body, preventing and treatinghypertension, preventing and treating cardiovascular diseases and the like are realized; the heat-resistant, antibacterial and sun-proof camellia flower nanometer microcapsule can be widely applied tothe industries of textiles, daily chemicals, foods, medicines, face beautifying, health care and the like.

Compositions and methods are provided for biologically relevant in vitro screening of neural function, including determination of the effects of an agent on neural cells. The compositions of the invention useful in such screening methods include a neural co-culture system comprising human pluripotent stem cell (PSC)-derived neurons and human glial cells, which may be derived by culture methods allowing for rapid and robust development of highly mature neuronal activity, particularly spontaneous synchronous network bursts.

Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

A process for preparing or manufacturing target molecular weight silk-derived oligopeptides with bioactive properties includes providing silk cocoon, extracting proteins or peptides from the silk cocoon, introducing an enzyme solution to obtain oligopeptides, and separating target oligopeptides from other peptides. Silk-derived oligopeptides in accordance with the present disclosure possess one or more of antioxidant properties, cholesterol lowering activity, lipid oxidation prevention properties, blood sugar lowering properties, blood pressure lowering properties, natural killer cell enhancement activity, insulin production enhancement activity, body weight regulatory activity, central nervous system stimulant properties, and neuroprotective, cognitive function protective, memory protective, and / or neural function improvement properties (e.g., memory deficit alleviation, spatial memory improvement, recognition memory improvement, learning improvement, synaptic transmission facilitation, and anti -neurodegenerative properties).

The present invention discloses the use of potassium 2-(α-hydroxypentyl) benzoate in the manufacture of medicaments for preventing, relieving or treating senile dementia diseases or symptom, and for relieving oxidative stress injury in brain tissue, increasing neural function of choline, protecting neuron and / or raising the content of brain nerve growth factor. The present invention also discloses a pharmaceutical composition comprising potassium 2-(α-hydroxypentyl) benzoate in prophylactically or therapeutically effective dose, optionally, a pharmaceutically acceptable carrier and / or adjuvant.

The invention discloses a production process of tea gamma-aminobutyric acid, comprising the following steps of: filtering and mixing fermentation product gamma-aminobutyric acid bacterial liquid which is obtained by lactic acid bacteria fermentation and cell transformation and a gamma-aminobutyric acid extract extracted from the tea; adding an enzyme reaction solution; and carrying out vacuum condensation and spraying and drying to obtain tea gamma-aminobutyric acid powder. The gamma-aminobutyric acid powder has the functions of improving the neural function and brain function, settling down the sprit, improving liver function and kidney function, adjusting hormone secretion, promoting the alcohol metabolism and deodorizing.