355 results about "Inner ear" patented technology

Disclosed embodiments relate to devices, systems, and methods of shaping, shrinking, opening, dilating, stiffening, or otherwise modifying a Eustachian tube and its surrounding tissue in order to improve the Eustachian tube's function. For example, patients with blocked, closed, or hypertrophic Eustachian tubes may be able to achieve improved function including easier equalization of pressure between the inner ear and environment.

The invention relates to a cochlea spiral neuron in-vitro organ as well as a construction method and application thereof, and provides a method for obtaining a mature inner ear neuron by utilizing human pluripotent stem cell differentiation in vitro and further constructing an inner ear neuron in-vitro organ on the basis of the mature inner ear neuron. The internal ear neuron in-vitro organoid function stage obtained by the method and the application thereof are also provided.

The invention discloses a Myo6 gene enhancer and application thereof, and belongs to the field of gene engineering. The Myo6 gene enhancer can drive the expression capacity of a reporter gene EGFP or Myo6 gene in the inner ear to be obviously enhanced, can be used for biological materials such as recombinant DNA, vectors or adenoviruses and the like, promotes the expression of the Myo6 gene or other genes in the inner ear so as to carry out gene expression regulation and control research, and is expected to be used for gene therapy of deafness.

This disclosure relates compositions and methods to delivery of various agents to the inner ear of a subject.

The invention discloses a construction method for a large-span truss steel structure roof. The construction method comprises the following steps that 1, roof splicing is completed on a floor slab surface; the joint shaft joint outer lug plate is fixed to the roof; 2, the roof is lifted upwards through a lifting system, and after the roof is lifted to the first height, the assembling jig frame is disassembled; 3, a joint shaft joint inner lug plate fixed to the end of the bifurcated column is inserted between the two joint shaft joint outer lug plates, and a pin shaft is inserted into a pin shaft hole in the lug plate; 4, the roof is lifted step by step, and in the lifting process, the bifurcated columns are adjusted to be in the vertical posture from the inclined posture; continuously lifting the roof to the designed height; and 5, adjusting the posture of the bifurcated column, and connecting the lower end of the bifurcated column with the top of the supporting column. The method solves the problems that the joint shaft of the bifurcated column is difficult to install, the bifurcated column cannot be hoisted in place in a high-altitude narrow space, and the pin shaft of the joint shaft of the bifurcated column is high in high-altitude assembly difficulty.

The present invention relates to a method for automatically segmenting the cochlea of a person comprised in an image (M) comprised of voxels (v) each voxel comprising an intensity value being indicative of the intensity of the respective voxel (v).

A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

Systems and methods can be employed for facilitating access and procedures in the outer, middle, and inner ear in order to diagnose or treat ear disorders including, but not limited to hearing loss and excessive ear wax. In some examples, the systems and methods include instruments and techniques that facilitate trans-tympanic membrane or trans-fibrous ring access to the middle ear. The systems and methods can also be used to improve accessibility for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

Cochlear implant systems can include an inner ear sensor configured to receive a stimulus signal from the cochlear tissue of a wearer and generate an input signal based on the received stimulus signal. The inner ear sensor can be configured to detect pressure, for example, within a wearer's cochlear tissue and generate an input signal based on the detected pressure. The inner ear sensor can be integrated with a cochlear electrode implanted in the cochlear tissue. Systems can include a signal processor programmed with a transfer function and configured to receive an input signal and output a stimulation signal based on the received input signal and transfer function. Systems can include an implantable battery and / or communication module in communication with the signal processor. The implantable battery and / or communication module can be configured to interface with and update the transfer function of the signal processor.

A tuned-frequency-spectrum earpiece for selectively tuning audio frequencies that enter an inner ear of a user wearing the earpiece, the earpiece including a base having an emitter end and receiver end, the base including a channel that passes through an entirety of the base; a sound-attenuation plug, wherein the sound-attenuation plug is configured to couple to the base such that the sound-attenuation plug surrounds at least a portion of the channel of the base; a first filter device configured to insert into the channel of the base and to selectively reject undesired frequencies of the audio frequencies that enter the earpiece; and a frequency-selective sound collector operatively coupled to the receiver end of the base and configured to increase an amount of desired frequencies of the audio frequencies that enter the first filter device. Some embodiments increase the amount of sound from some directions while reducing sound from other directions.

The invention discloses a temporal bone CT automatic segmentation method based on a convolutional neural network, and relates to the technical field of medical image processing, and the method comprises the steps: S1, data standardization; s2, a coarse segmentation stage; s3, a fine segmentation stage; and S4, a post-processing step. According to the temporal bone CT automatic segmentation method based on the convolutional neural network, through the four main steps of data standardization, coarse segmentation, fine segmentation and post-processing, rapid, accurate and automatic segmentation of the inner ear area in the temporal bone CT image can be achieved, the segmentation efficiency and accuracy are remarkably improved, and compared with the prior art, the method has the advantages that the segmentation efficiency is improved, and the segmentation efficiency is improved. According to the temporal bone CT key anatomical structure segmentation method, rapid and accurate segmentation of the temporal bone CT key anatomical structure is achieved through the two-stage convolutional neural network, the temporal bone CT key anatomical structure segmentation method has the advantages of being high in segmentation speed, precision and generalization ability and the like, important support is provided for clinical diagnosis, and the temporal bone CT key anatomical structure segmentation method has high clinical application value.

Presented herein are systems and techniques for using an external component / device to collect eye movement data that is complementary to neurological measures / measurements (e.g., EEG measurements, inner ear measurements, or other electrophysiological measurements) obtained by an implantable component / device. Recipient eye movement can be tracked directly (e.g., with smart glasses) and / or indirectly (e.g., using eye movement-related eardrum oscillations (EMREO) measurements). The systems and techniques presented herein can use an implantable component (e.g., a cochlear implant, an EEG implant, etc.) to obtain electrophysiological measurements from a recipient. According to aspects presented herein, the electrophysiological measurements and the eye movement measurements are analyzed together in order to, for example, diagnosis a medical condition, predict or characterize a medical event, etc.

This disclosure relates to delivery of various agents to the inner ear of a subject.

Disclosed embodiments relate to devices, systems, and methods of shaping, shrinking, opening, dilating, stiffening, or otherwise modifying a Eustachian tube and its surrounding tissue in order to improve the Eustachian tube's function. For example, patients with blocked, closed, or hypertrophic Eustachian tubes may be able to achieve improved function including easier equalization of pressure between the inner ear and environment.

The present application relates to a mass-loaded earplug with a ventilated chamber. An intra-concha earphone is disclosed. In an embodiment, the intra-concha earphone includes a housing having a rear space, which is divided into a rear cavity volume, a bass duct, and a ventilated chamber between a driver and a rear wall. The ventilated chamber can be acoustically coupled to the rear cavity volume through both an acoustic port and a bass duct. In addition, the ventilated chamber can be acoustically coupled to the surrounding environment through a vent port, wherein the vent port can be the only acoustic opening in the rear wall. Therefore, the sound emitted by the driver can propagate through the acoustic port and the bass duct to meet in the ventilated chamber before being released to the surrounding environment through the vent port. Other embodiments are also described and claimed.

Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

The present disclosure provides preventing and / or treating hearing loss in an individual in need thereof comprising administering a composition comprising one or more viral vectors comprising a nucleic acid encoding COL18A1 protein, SPARC protein, and IGFBP2 protein. The present disclosure also provides method for preventing and / or treating hearing loss in an individual in need thereof comprising administering an effective amount of COL18A1, SPARC, and IGFBP2 proteins to the inner ear of the individual.

The invention discloses a method for promoting maturation of cochlea organs in a GELMA-MXene matrix based on electroacoustic stimulation, and belongs to the field of cochlea organ culture for hair cell regeneration. The preparation method of the cochlea organ culture component comprises the following steps: preparing GelMA; sequentially adding LiF, MAX, pure water and acid into the reaction container; stirring the mixture until the reaction is completed, centrifuging the mixture, and removing supernate and MXene to obtain Ti3C2Tx; dissolving GelMA by using a light curing agent, and adding Ti < 3 > C < 2 > T < x >; and irradiating with blue light to obtain the cochlea organ culture component. Using the cochlea organ culture component to culture inner ear stem cells, and adding a differential medium; and after the differentiation is completed, applying low-frequency electroacoustic stimulation to the differentiated organoid. The advantages of a culture support and electroacoustic stimulation are combined, and differentiation and maturation of cochlea organs are more effectively promoted.

Disclosed are a fitting method and apparatus for a hearing earphone, which relate to the field of mobile Internet services. A specific embodiment of the method comprises: obtaining a test result of hearing threshold of a user, transmitting the test result of hearing threshold to a server, and then receiving a target compensation gain value of each of frequency bands, which value is calculated based on hearing earphone configuration information; and sending a generated pure tone signal to a hearing earphone for playing, receiving sound in an ear canal by means of an inner ear microphone arranged in the hearing earphone, so as to receive speech information generated by playing the pure tone signal, and further adjusting gain data of each of frequency bands to approximate a corresponding target compensation gain value. Therefore, the embodiments of the present invention can solve the problems of low fitting efficiency and reliability and high costs of existing hearing earphones.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

The invention relates to a dietary therapy formula for improving microcirculation of inner ears and a preparation method. Components with homology of medicine and food are selected, the black rice, the blueberries and the purple cabbages are rich in anthocyanin and beneficial to removing free radicals in cochlea and inhibiting hair cell apoptosis, the walnut kernels and the Chinese wolfberry fruits can improve blood vessel elasticity and protect auditory neurons, and the radix salviae miltiorrhizae, the hawthorn fruits and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, reduce blood viscosity and reduce vasospasm, so that the health-care food is suitable for being eaten by people. The whole component is low in sugar content, suitable for diabetics and capable of expanding the crowd. Effective components are processed into non-medicinal products, food therapy is beneficial to improving microcirculation of inner ears, relieving ear symptoms such as tinnitus and the like and delaying hearing loss, and a user can eat the food for a long time without psychological burden of medication.

A vestibular function improvement device (100) according to the present invention comprises: a generation unit (1) that generates an electric signal that causes a vibration including a frequency component in the range of 450-1500 hertz; and an output unit (2) that outputs a stimulus on the basis of the electric signal. The stimulus outputted by the output unit (2) is transmitted to the vestibular system of the inner ear. According to the present invention, vestibular functions can be improved by stimulating the vestibular system of the inner ear.

The Y-shaped battery tab comprises a tab metal belt and a tab adhesive tape, and the tab adhesive tape is hot-pressed on the tab metal belt and is used for being compositely sealed with a battery packaging film; the tab metal belt comprises an outer tab belt located outside the battery and at least two inner tab belts located inside the battery, one inner tab belt is a main metal belt integrated with the outer tab belt, the other inner tab belt is an auxiliary metal belt, the head end of the auxiliary metal belt is welded with the main metal belt in parallel, and the outer tab belt and the auxiliary metal belt are welded in parallel. The tail end of the auxiliary metal belt is branched from the main metal belt and is respectively welded with the positive electrode or the negative electrode of a battery current collector so as to lead out current; and the two symmetrically arranged tab rubber strips are compounded at the welding seam in a hot pressing manner. And the tab lead welding process is reduced, and the energy density is improved. And the related production cost of the battery cell and the tab can be greatly reduced. And the traditional welding mode of the positive and negative current collectors of the laminated battery is changed. The purpose of higher charging speed is achieved, and the welding difficulty of the positive and negative current collectors and the tabs is reduced.

A body supports a speaker and an ear cushion adjacent a proximal portion thereof. The ear cushion is sized to fit within an ear canal of a user for holding of the earbud in position and directing sound from the speaker into the ear of the user. A distal end of the body supports a turn wheel in a rotational fashion relative to the body. The turn wheel has frictional resistance to rotation relative to the body which is less than friction force between the ear cushion and the inner ear of the user, such that torque applied to the turn wheel causes the turn wheel to rotate relative to the body. Rotation of the turn wheel causes at least one characteristic of sound emanating from the speaker of the earbud to be modified. A charger box is also provided which can contain and wirelessly charge a pair of earbuds.

The system according to the embodiment aims to eliminate inconveniences in daily life caused by hearing impairments or hearing loss. According to an embodiment, the system includes a collection unit, an analysis unit, and a transmission unit. The collection unit collects ambient sound. The analysis unit analyzes the sound collected by the collection unit. The transmission unit transmits the sound analyzed by the analysis unit to the inner ear using bone conduction technology.

The application relates to a micro actuator for inner ear injection sampling surgery, and relates to the field of medical instruments.The application solves the problems that the existing actuator cannot more accurately assist the doctor in judging the surgery progress, lacks clinical surgery practicability in design, and makes the otological surgery still have certain operation difficulty.The microneedle puncture mechanism module is embedded in the driving and sensing module, the driving and sensing module is installed on the high-precision linear driving module, the end operation mechanism module is installed at the front of the driving and sensing module, the microneedle puncture mechanism module passes through the end operation mechanism module and extends out, and the endoscope camera module in the end operation mechanism module provides real-time images in the surgery process, the tension sensor in the driving and sensing module monitors the change of the steel wire tension in real time, and safety interaction with the ear canal environment is ensured.The application is used for inner ear injection sampling surgery.

Disclosed herein are compositions and methods for preventing or attenuating the development of fibrosis and scarring, or for treating fibrosis and scarring that have resulted from implantation trauma, implantation and maintenance of a foreign body in the inner ear, such as a cochlear or vestibular implant, or from damage resulting from other injury to the inner ear, such as, for example, from electrical stimulation from an implant electrode.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The utility model discloses a medicine spraying device for ear-nose-throat, which comprises a handle part, a positioning blocking component and a jet-propelled medicine applying component, the positioning blocking component is arranged at the front end of the handle part, and the jet-propelled medicine applying component is arranged in the middle of the handle part. The positioning blocking assembly comprises a front-end catheter, a cross-shaped positioning frame, a hard guide wire, a self-adaptive telescopic assembly, a telescopic control assembly and a reset assembly, the front end of the handle part is fixedly connected with the front-end catheter, the front-end catheter is communicated with the handle part, and the cross-shaped positioning frame is fixedly connected to the middle of the end, away from the handle part, of the front-end catheter. According to the medicine spraying device for the ear-nose-throat, the positioning blocking assembly is arranged, after the traction ring is separated from the surface of the elastic piece, the elastic piece is automatically unfolded and matched with the telescopic soft film to be unfolded according to the shape of the interior of the ear, the interior of the ear can be isolated from the exterior, and at the moment, medicine does not enter the inner ear when applied to the interior of the ear; therefore, the convenience of medicine application is improved.

The invention discloses a rotating steel bar damper of a four-connecting-rod structure. The rotating steel bar damper comprises an outer lug plate, an inner lug plate, an energy dissipation steel bar, a pin shaft and a sleeve. According to the rotating steel bar damper of the four-connecting-rod structure, the damper can deform in any direction in a plane, each pin shaft and the corresponding energy dissipation steel bar surrounding one circle of the pin shaft form a single rotating unit, under the earthquake effect, when the outer lug plate moves in a certain direction, the outer lug plate and the inner lug plate rotate relatively, and therefore the rotating steel bar damper can deform in any direction. The shearing force between the outer lug plate and the inner lug plate is borne by the pin shaft, the bending moment generated by relative rotation of the outer lug plate and the inner lug plate is borne by the energy dissipation steel bar, bending-shearing separation is achieved through the structure, overall plastic deformation of the damper is concentrated on the energy dissipation section of the energy dissipation steel bar, and earthquake energy is dissipated through shearing plastic deformation of the energy dissipation steel bar. And according to the damper, translation deformation is converted into rotation deformation through a four-connecting-rod structure, and the deformation capacity of the metal shearing type damper is improved.