258 results about "Inner ear" patented technology

The invention relates to a cochlea spiral neuron in-vitro organ as well as a construction method and application thereof, and provides a method for obtaining a mature inner ear neuron by utilizing human pluripotent stem cell differentiation in vitro and further constructing an inner ear neuron in-vitro organ on the basis of the mature inner ear neuron. The internal ear neuron in-vitro organoid function stage obtained by the method and the application thereof are also provided.

The invention discloses a construction method for a large-span truss steel structure roof. The construction method comprises the following steps that 1, roof splicing is completed on a floor slab surface; the joint shaft joint outer lug plate is fixed to the roof; 2, the roof is lifted upwards through a lifting system, and after the roof is lifted to the first height, the assembling jig frame is disassembled; 3, a joint shaft joint inner lug plate fixed to the end of the bifurcated column is inserted between the two joint shaft joint outer lug plates, and a pin shaft is inserted into a pin shaft hole in the lug plate; 4, the roof is lifted step by step, and in the lifting process, the bifurcated columns are adjusted to be in the vertical posture from the inclined posture; continuously lifting the roof to the designed height; and 5, adjusting the posture of the bifurcated column, and connecting the lower end of the bifurcated column with the top of the supporting column. The method solves the problems that the joint shaft of the bifurcated column is difficult to install, the bifurcated column cannot be hoisted in place in a high-altitude narrow space, and the pin shaft of the joint shaft of the bifurcated column is high in high-altitude assembly difficulty.

The present invention relates to a method for automatically segmenting the cochlea of a person comprised in an image (M) comprised of voxels (v) each voxel comprising an intensity value being indicative of the intensity of the respective voxel (v).

A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

Systems and methods can be employed for facilitating access and procedures in the outer, middle, and inner ear in order to diagnose or treat ear disorders including, but not limited to hearing loss and excessive ear wax. In some examples, the systems and methods include instruments and techniques that facilitate trans-tympanic membrane or trans-fibrous ring access to the middle ear. The systems and methods can also be used to improve accessibility for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

A tuned-frequency-spectrum earpiece for selectively tuning audio frequencies that enter an inner ear of a user wearing the earpiece, the earpiece including a base having an emitter end and receiver end, the base including a channel that passes through an entirety of the base; a sound-attenuation plug, wherein the sound-attenuation plug is configured to couple to the base such that the sound-attenuation plug surrounds at least a portion of the channel of the base; a first filter device configured to insert into the channel of the base and to selectively reject undesired frequencies of the audio frequencies that enter the earpiece; and a frequency-selective sound collector operatively coupled to the receiver end of the base and configured to increase an amount of desired frequencies of the audio frequencies that enter the first filter device. Some embodiments increase the amount of sound from some directions while reducing sound from other directions.

Disclosed embodiments relate to devices, systems, and methods of shaping, shrinking, opening, dilating, stiffening, or otherwise modifying a Eustachian tube and its surrounding tissue in order to improve the Eustachian tube's function. For example, patients with blocked, closed, or hypertrophic Eustachian tubes may be able to achieve improved function including easier equalization of pressure between the inner ear and environment.

The present application relates to a mass-loaded earplug with a ventilated chamber. An intra-concha earphone is disclosed. In an embodiment, the intra-concha earphone includes a housing having a rear space, which is divided into a rear cavity volume, a bass duct, and a ventilated chamber between a driver and a rear wall. The ventilated chamber can be acoustically coupled to the rear cavity volume through both an acoustic port and a bass duct. In addition, the ventilated chamber can be acoustically coupled to the surrounding environment through a vent port, wherein the vent port can be the only acoustic opening in the rear wall. Therefore, the sound emitted by the driver can propagate through the acoustic port and the bass duct to meet in the ventilated chamber before being released to the surrounding environment through the vent port. Other embodiments are also described and claimed.

Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

The present disclosure provides preventing and / or treating hearing loss in an individual in need thereof comprising administering a composition comprising one or more viral vectors comprising a nucleic acid encoding COL18A1 protein, SPARC protein, and IGFBP2 protein. The present disclosure also provides method for preventing and / or treating hearing loss in an individual in need thereof comprising administering an effective amount of COL18A1, SPARC, and IGFBP2 proteins to the inner ear of the individual.

The invention discloses a method for promoting maturation of cochlea organs in a GELMA-MXene matrix based on electroacoustic stimulation, and belongs to the field of cochlea organ culture for hair cell regeneration. The preparation method of the cochlea organ culture component comprises the following steps: preparing GelMA; sequentially adding LiF, MAX, pure water and acid into the reaction container; stirring the mixture until the reaction is completed, centrifuging the mixture, and removing supernate and MXene to obtain Ti3C2Tx; dissolving GelMA by using a light curing agent, and adding Ti < 3 > C < 2 > T < x >; and irradiating with blue light to obtain the cochlea organ culture component. Using the cochlea organ culture component to culture inner ear stem cells, and adding a differential medium; and after the differentiation is completed, applying low-frequency electroacoustic stimulation to the differentiated organoid. The advantages of a culture support and electroacoustic stimulation are combined, and differentiation and maturation of cochlea organs are more effectively promoted.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

The invention relates to a dietary therapy formula for improving microcirculation of inner ears and a preparation method. Components with homology of medicine and food are selected, the black rice, the blueberries and the purple cabbages are rich in anthocyanin and beneficial to removing free radicals in cochlea and inhibiting hair cell apoptosis, the walnut kernels and the Chinese wolfberry fruits can improve blood vessel elasticity and protect auditory neurons, and the radix salviae miltiorrhizae, the hawthorn fruits and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, reduce blood viscosity and reduce vasospasm, so that the health-care food is suitable for being eaten by people. The whole component is low in sugar content, suitable for diabetics and capable of expanding the crowd. Effective components are processed into non-medicinal products, food therapy is beneficial to improving microcirculation of inner ears, relieving ear symptoms such as tinnitus and the like and delaying hearing loss, and a user can eat the food for a long time without psychological burden of medication.

The Y-shaped battery tab comprises a tab metal belt and a tab adhesive tape, and the tab adhesive tape is hot-pressed on the tab metal belt and is used for being compositely sealed with a battery packaging film; the tab metal belt comprises an outer tab belt located outside the battery and at least two inner tab belts located inside the battery, one inner tab belt is a main metal belt integrated with the outer tab belt, the other inner tab belt is an auxiliary metal belt, the head end of the auxiliary metal belt is welded with the main metal belt in parallel, and the outer tab belt and the auxiliary metal belt are welded in parallel. The tail end of the auxiliary metal belt is branched from the main metal belt and is respectively welded with the positive electrode or the negative electrode of a battery current collector so as to lead out current; and the two symmetrically arranged tab rubber strips are compounded at the welding seam in a hot pressing manner. And the tab lead welding process is reduced, and the energy density is improved. And the related production cost of the battery cell and the tab can be greatly reduced. And the traditional welding mode of the positive and negative current collectors of the laminated battery is changed. The purpose of higher charging speed is achieved, and the welding difficulty of the positive and negative current collectors and the tabs is reduced.

A body supports a speaker and an ear cushion adjacent a proximal portion thereof. The ear cushion is sized to fit within an ear canal of a user for holding of the earbud in position and directing sound from the speaker into the ear of the user. A distal end of the body supports a turn wheel in a rotational fashion relative to the body. The turn wheel has frictional resistance to rotation relative to the body which is less than friction force between the ear cushion and the inner ear of the user, such that torque applied to the turn wheel causes the turn wheel to rotate relative to the body. Rotation of the turn wheel causes at least one characteristic of sound emanating from the speaker of the earbud to be modified. A charger box is also provided which can contain and wirelessly charge a pair of earbuds.

The system according to the embodiment aims to eliminate inconveniences in daily life caused by hearing impairments or hearing loss. According to an embodiment, the system includes a collection unit, an analysis unit, and a transmission unit. The collection unit collects ambient sound. The analysis unit analyzes the sound collected by the collection unit. The transmission unit transmits the sound analyzed by the analysis unit to the inner ear using bone conduction technology.

The application relates to a micro actuator for inner ear injection sampling surgery, and relates to the field of medical instruments.The application solves the problems that the existing actuator cannot more accurately assist the doctor in judging the surgery progress, lacks clinical surgery practicability in design, and makes the otological surgery still have certain operation difficulty.The microneedle puncture mechanism module is embedded in the driving and sensing module, the driving and sensing module is installed on the high-precision linear driving module, the end operation mechanism module is installed at the front of the driving and sensing module, the microneedle puncture mechanism module passes through the end operation mechanism module and extends out, and the endoscope camera module in the end operation mechanism module provides real-time images in the surgery process, the tension sensor in the driving and sensing module monitors the change of the steel wire tension in real time, and safety interaction with the ear canal environment is ensured.The application is used for inner ear injection sampling surgery.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The utility model discloses a medicine spraying device for ear-nose-throat, which comprises a handle part, a positioning blocking component and a jet-propelled medicine applying component, the positioning blocking component is arranged at the front end of the handle part, and the jet-propelled medicine applying component is arranged in the middle of the handle part. The positioning blocking assembly comprises a front-end catheter, a cross-shaped positioning frame, a hard guide wire, a self-adaptive telescopic assembly, a telescopic control assembly and a reset assembly, the front end of the handle part is fixedly connected with the front-end catheter, the front-end catheter is communicated with the handle part, and the cross-shaped positioning frame is fixedly connected to the middle of the end, away from the handle part, of the front-end catheter. According to the medicine spraying device for the ear-nose-throat, the positioning blocking assembly is arranged, after the traction ring is separated from the surface of the elastic piece, the elastic piece is automatically unfolded and matched with the telescopic soft film to be unfolded according to the shape of the interior of the ear, the interior of the ear can be isolated from the exterior, and at the moment, medicine does not enter the inner ear when applied to the interior of the ear; therefore, the convenience of medicine application is improved.

The invention discloses a rotating steel bar damper of a four-connecting-rod structure. The rotating steel bar damper comprises an outer lug plate, an inner lug plate, an energy dissipation steel bar, a pin shaft and a sleeve. According to the rotating steel bar damper of the four-connecting-rod structure, the damper can deform in any direction in a plane, each pin shaft and the corresponding energy dissipation steel bar surrounding one circle of the pin shaft form a single rotating unit, under the earthquake effect, when the outer lug plate moves in a certain direction, the outer lug plate and the inner lug plate rotate relatively, and therefore the rotating steel bar damper can deform in any direction. The shearing force between the outer lug plate and the inner lug plate is borne by the pin shaft, the bending moment generated by relative rotation of the outer lug plate and the inner lug plate is borne by the energy dissipation steel bar, bending-shearing separation is achieved through the structure, overall plastic deformation of the damper is concentrated on the energy dissipation section of the energy dissipation steel bar, and earthquake energy is dissipated through shearing plastic deformation of the energy dissipation steel bar. And according to the damper, translation deformation is converted into rotation deformation through a four-connecting-rod structure, and the deformation capacity of the metal shearing type damper is improved.

This utility model discloses a low-noise centrifugal pump for petrochemical applications, comprising a centrifugal pump body, an impeller movably mounted inside the pump body with an impeller shaft mounted on it, an inlet pipe at the front of the pump body, a drain pipe at the top of the pump body, and a low-noise mechanism wrapped around the outside of the pump body. The low-noise mechanism consists of noise reduction covers A, B, C, and D. Noise reduction cover B is fixedly mounted at one end of noise reduction cover A, and noise reduction cover D is fixedly mounted at one end of noise reduction cover C. This low-noise centrifugal pump for petrochemical applications features modularly designed noise reduction covers that can be quickly installed using a mounting bracket without complex tools or specialized skills, reducing the noise level generated by the centrifugal pump and preventing damage to the inner ear hair cells of factory workers, thus avoiding irreversible hearing loss. The rock wool itself has a porous fiber structure, primarily absorbing mid-to-high frequency noise.

An ear-worn electronic device comprises a housing configured for deployment in, on or about an ear of a wearer and a power source situated in the housing. A sensor is situated in or on the housing and coupled to the power source. The sensor is configured to generate a sensor signal representative of motion of the wearer's head and relative motion between the sensor and skin of the wearer's ear resulting from the wearer's head motion. A controller is situated in the housing and coupled to the power source and the sensor. The controller is configured to assess a fit of the device using the sensor signal.

The invention relates to the technical field of biology, in particular to a construction method of an Elmod3 gene mutation mouse model. Based on clinical data of hereditary deafness family patients, ELMOD3c.512Agt is found; g abnormal mutation can cause delayed progressive sensorineural deafness of a patient. According to the invention, a molecular marker with Elmod3c.512Agt is constructed; the G point mutation mouse model is consistent with the mutation site of a patient, and after the mouse is born, the disease progresses under the normal feeding environment and the natural growth rule, so that the experiment conditions of the disease research of the model mouse are closer to the real disease development of family patients, and a researcher can deeply research how the ELMOD3 gene mutation causes deafness. And a foundation is laid for functional research and subsequent gene therapy research of the ELMOD3 in an inner ear auditory system.

The application provides a press-immersion type waste pipette tip storage and disinfection container, which comprises a multi-groove inner ear seat barrel cup, a rack, an upper push rod, a lower rod piece, a pressing plate, an elastic sheet, a ventilation protrusion and a base, the lower part of the outer wall of the multi-groove inner ear seat barrel cup is detachably connected to the base, the upper part of the lower rod piece is hingedly connected to the lower end of the upper push rod, the gear at the lower part of the lower rod piece is hingedly connected inside the multi-groove inner ear seat barrel cup, one end of the pressing plate is hingedly connected to the middle part inside the multi-groove inner ear seat barrel cup, the rack is slidingly connected to the inner wall of the multi-groove inner ear seat barrel cup, the teeth on the rack are engaged with the gears on the lower rod piece and the gears on the pressing plate, one side of the elastic sheet is fixedly connected to the lower surface of the pressing plate, and the ventilation protrusion is arranged on one side of the elastic sheet or the lower surface of the pressing plate. The application not only prevents tilting and saves energy, but also enables the waste pipette tip thrown each time to be immersed in disinfectant for complete disinfection in time, and the disinfectant and the waste pipette tip are separated for convenient operation.

The present solution provides a system and method for transround window membrane drug delivery. In summary, the system includes a micropump connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce a patient's round window membrane. The handpiece allows the cannula to be inserted into the round window membrane, improving distribution of the delivered drug throughout the inner ear. The present solution can function as a small, implantable or wearable device that can be used for chronic and acute transround window membrane drug delivery. This configuration allows the micropump to deliver small amounts of drug from an internal reservoir continuously or intermittently over a period of days to months.

The utility model discloses a bone conduction earphone loudspeaker structure, which comprises a conduction surface cover, a support, a vibrating reed, a voice coil, a PCB (printed circuit board), U iron, a washer and a magnet, the support is arranged at one end of the conduction surface cover, the support is provided with a cavity, the PCB, the voice coil, the washer, the magnet and the U iron are sequentially arranged on the cavity, the vibrating reed is a titanium vibrating reed, the vibrating reed is arranged between the conduction surface cover and the support, and the vibrating reed and the U iron are in contact positioning; thus, through the design that the vibrating reed is made of a metal material, and the vibrating reed is arranged between the bracket and the conduction surface cover, the structural firmness and the anti-falling effect of the bone conduction loudspeaker on the earphone are improved, and the stability when the bone conduction loudspeaker drives the earphone shell to vibrate so as to conduct sound waves to the inner ear is ensured; the sound conduction of the bone conduction earphone is clearer, so that the use experience of a user is improved, the usability is good, and the application range is wide.

The utility model relates to a sliding rail box sleeving full-automatic packaging machine. A sliding rail folding mechanism, a sliding rail box sleeving mechanism, a finished product conveying support, a box piece conveying mechanism, a box piece adsorption mechanism, a box piece pull-down mechanism, a paper box conveying mechanism, a box folding mechanism and a box pushing mechanism are arranged on a rack. Comprising the steps of sliding rail folding, sliding rail falling and sliding rail pushing to a box sleeving station; obliquely arranging the box piece, inclining the box piece, horizontally arranging the box piece, adsorbing the formed box, converging the inner lugs, bending the box cover, cutting and pressing the insertion lugs, pushing and pressing the box cover and inserting the insertion lugs, and sealing the box at a box insertion station; the two ends of the sliding rail are sleeved with boxes. The device has the advantages that the box pieces are obliquely placed and cannot fall down, all mechanisms are compact, and installation and maintenance are convenient.

The utility model provides a kind of medical handheld device and inner ear dosing device;The medical handheld device includes handheld shell and connector at one end of handheld shell;The connector has the through setting connector inner cavity, and handheld shell has the shell inner cavity being communicated with connector inner cavity;The connector is used for the detachable connection with the needle holder of puncture needle, and the connector inner cavity of connector is used for the sealed insertion of duct, so that, operator only needs to insert puncture needle into inner ear by medical handheld device, direct dosing of inner ear can be carried out, there is only one insertion operation in the whole process, effectively simplify operation process, improve operation convenience.

1. The name of the design product: hairpin (inner ear decorative panda). 2. The use of the design product: hairpin, doll. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: front view. 5. The design for which protection is sought includes color. 6. The bottom of the design product is not easily visible or invisible during use, and the top view is omitted.

The utility model discloses an RIC type hearing aid, and aims to solve the problems that an existing hearing aid is charged mainly through an external USB charging line, poor contact is caused due to frequent plugging and unplugging, the hearing aid cannot be charged at any time, and inconvenience is brought to a user. The hearing aid comprises a charging bin, a cover rotationally connected with the charging bin and two hearing-aid earphones, two earphone charging grooves are formed in the front side of the upper surface of the charging bin, two charging plugs are installed on the inner bottom walls of the earphone charging grooves, a groove is formed in the rear side of the upper surface of the charging bin, and each hearing-aid earphone comprises a host, a sound guide tube, an ear cap and a loudspeaker. The storage battery is arranged in the charging bin, the earphone charging groove and the groove are formed in the upper portion of the charging bin, and the hearing-aid earphone can be charged only by placing the host in the earphone charging groove, placing the ear cap in the groove and closing the cover during charging, so that charging of the hearing-aid earphone is more convenient and faster, and stable transmission of electric energy can be achieved.