190 results about "Inner ear" patented technology

A tuned-frequency-spectrum earpiece for selectively tuning audio frequencies that enter an inner ear of a user wearing the earpiece, the earpiece including a base having an emitter end and receiver end, the base including a channel that passes through an entirety of the base; a sound-attenuation plug, wherein the sound-attenuation plug is configured to couple to the base such that the sound-attenuation plug surrounds at least a portion of the channel of the base; a first filter device configured to insert into the channel of the base and to selectively reject undesired frequencies of the audio frequencies that enter the earpiece; and a frequency-selective sound collector operatively coupled to the receiver end of the base and configured to increase an amount of desired frequencies of the audio frequencies that enter the first filter device. Some embodiments increase the amount of sound from some directions while reducing sound from other directions.

Disclosed embodiments relate to devices, systems, and methods of shaping, shrinking, opening, dilating, stiffening, or otherwise modifying a Eustachian tube and its surrounding tissue in order to improve the Eustachian tube's function. For example, patients with blocked, closed, or hypertrophic Eustachian tubes may be able to achieve improved function including easier equalization of pressure between the inner ear and environment.

The present disclosure provides preventing and / or treating hearing loss in an individual in need thereof comprising administering a composition comprising one or more viral vectors comprising a nucleic acid encoding COL18A1 protein, SPARC protein, and IGFBP2 protein. The present disclosure also provides method for preventing and / or treating hearing loss in an individual in need thereof comprising administering an effective amount of COL18A1, SPARC, and IGFBP2 proteins to the inner ear of the individual.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

The invention relates to a dietary therapy formula for improving microcirculation of inner ears and a preparation method. Components with homology of medicine and food are selected, the black rice, the blueberries and the purple cabbages are rich in anthocyanin and beneficial to removing free radicals in cochlea and inhibiting hair cell apoptosis, the walnut kernels and the Chinese wolfberry fruits can improve blood vessel elasticity and protect auditory neurons, and the radix salviae miltiorrhizae, the hawthorn fruits and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, reduce blood viscosity and reduce vasospasm, so that the health-care food is suitable for being eaten by people. The whole component is low in sugar content, suitable for diabetics and capable of expanding the crowd. Effective components are processed into non-medicinal products, food therapy is beneficial to improving microcirculation of inner ears, relieving ear symptoms such as tinnitus and the like and delaying hearing loss, and a user can eat the food for a long time without psychological burden of medication.

A body supports a speaker and an ear cushion adjacent a proximal portion thereof. The ear cushion is sized to fit within an ear canal of a user for holding of the earbud in position and directing sound from the speaker into the ear of the user. A distal end of the body supports a turn wheel in a rotational fashion relative to the body. The turn wheel has frictional resistance to rotation relative to the body which is less than friction force between the ear cushion and the inner ear of the user, such that torque applied to the turn wheel causes the turn wheel to rotate relative to the body. Rotation of the turn wheel causes at least one characteristic of sound emanating from the speaker of the earbud to be modified. A charger box is also provided which can contain and wirelessly charge a pair of earbuds.

The system according to the embodiment aims to eliminate inconveniences in daily life caused by hearing impairments or hearing loss. According to an embodiment, the system includes a collection unit, an analysis unit, and a transmission unit. The collection unit collects ambient sound. The analysis unit analyzes the sound collected by the collection unit. The transmission unit transmits the sound analyzed by the analysis unit to the inner ear using bone conduction technology.

The application relates to a micro actuator for inner ear injection sampling surgery, and relates to the field of medical instruments.The application solves the problems that the existing actuator cannot more accurately assist the doctor in judging the surgery progress, lacks clinical surgery practicability in design, and makes the otological surgery still have certain operation difficulty.The microneedle puncture mechanism module is embedded in the driving and sensing module, the driving and sensing module is installed on the high-precision linear driving module, the end operation mechanism module is installed at the front of the driving and sensing module, the microneedle puncture mechanism module passes through the end operation mechanism module and extends out, and the endoscope camera module in the end operation mechanism module provides real-time images in the surgery process, the tension sensor in the driving and sensing module monitors the change of the steel wire tension in real time, and safety interaction with the ear canal environment is ensured.The application is used for inner ear injection sampling surgery.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The utility model discloses a medicine spraying device for ear-nose-throat, which comprises a handle part, a positioning blocking component and a jet-propelled medicine applying component, the positioning blocking component is arranged at the front end of the handle part, and the jet-propelled medicine applying component is arranged in the middle of the handle part. The positioning blocking assembly comprises a front-end catheter, a cross-shaped positioning frame, a hard guide wire, a self-adaptive telescopic assembly, a telescopic control assembly and a reset assembly, the front end of the handle part is fixedly connected with the front-end catheter, the front-end catheter is communicated with the handle part, and the cross-shaped positioning frame is fixedly connected to the middle of the end, away from the handle part, of the front-end catheter. According to the medicine spraying device for the ear-nose-throat, the positioning blocking assembly is arranged, after the traction ring is separated from the surface of the elastic piece, the elastic piece is automatically unfolded and matched with the telescopic soft film to be unfolded according to the shape of the interior of the ear, the interior of the ear can be isolated from the exterior, and at the moment, medicine does not enter the inner ear when applied to the interior of the ear; therefore, the convenience of medicine application is improved.

The invention discloses a rotating steel bar damper of a four-connecting-rod structure. The rotating steel bar damper comprises an outer lug plate, an inner lug plate, an energy dissipation steel bar, a pin shaft and a sleeve. According to the rotating steel bar damper of the four-connecting-rod structure, the damper can deform in any direction in a plane, each pin shaft and the corresponding energy dissipation steel bar surrounding one circle of the pin shaft form a single rotating unit, under the earthquake effect, when the outer lug plate moves in a certain direction, the outer lug plate and the inner lug plate rotate relatively, and therefore the rotating steel bar damper can deform in any direction. The shearing force between the outer lug plate and the inner lug plate is borne by the pin shaft, the bending moment generated by relative rotation of the outer lug plate and the inner lug plate is borne by the energy dissipation steel bar, bending-shearing separation is achieved through the structure, overall plastic deformation of the damper is concentrated on the energy dissipation section of the energy dissipation steel bar, and earthquake energy is dissipated through shearing plastic deformation of the energy dissipation steel bar. And according to the damper, translation deformation is converted into rotation deformation through a four-connecting-rod structure, and the deformation capacity of the metal shearing type damper is improved.

This utility model discloses a low-noise centrifugal pump for petrochemical applications, comprising a centrifugal pump body, an impeller movably mounted inside the pump body with an impeller shaft mounted on it, an inlet pipe at the front of the pump body, a drain pipe at the top of the pump body, and a low-noise mechanism wrapped around the outside of the pump body. The low-noise mechanism consists of noise reduction covers A, B, C, and D. Noise reduction cover B is fixedly mounted at one end of noise reduction cover A, and noise reduction cover D is fixedly mounted at one end of noise reduction cover C. This low-noise centrifugal pump for petrochemical applications features modularly designed noise reduction covers that can be quickly installed using a mounting bracket without complex tools or specialized skills, reducing the noise level generated by the centrifugal pump and preventing damage to the inner ear hair cells of factory workers, thus avoiding irreversible hearing loss. The rock wool itself has a porous fiber structure, primarily absorbing mid-to-high frequency noise.

An ear-worn electronic device comprises a housing configured for deployment in, on or about an ear of a wearer and a power source situated in the housing. A sensor is situated in or on the housing and coupled to the power source. The sensor is configured to generate a sensor signal representative of motion of the wearer's head and relative motion between the sensor and skin of the wearer's ear resulting from the wearer's head motion. A controller is situated in the housing and coupled to the power source and the sensor. The controller is configured to assess a fit of the device using the sensor signal.

The invention relates to the technical field of biology, in particular to a construction method of an Elmod3 gene mutation mouse model. Based on clinical data of hereditary deafness family patients, ELMOD3c.512Agt is found; g abnormal mutation can cause delayed progressive sensorineural deafness of a patient. According to the invention, a molecular marker with Elmod3c.512Agt is constructed; the G point mutation mouse model is consistent with the mutation site of a patient, and after the mouse is born, the disease progresses under the normal feeding environment and the natural growth rule, so that the experiment conditions of the disease research of the model mouse are closer to the real disease development of family patients, and a researcher can deeply research how the ELMOD3 gene mutation causes deafness. And a foundation is laid for functional research and subsequent gene therapy research of the ELMOD3 in an inner ear auditory system.

The application provides a press-immersion type waste pipette tip storage and disinfection container, which comprises a multi-groove inner ear seat barrel cup, a rack, an upper push rod, a lower rod piece, a pressing plate, an elastic sheet, a ventilation protrusion and a base, the lower part of the outer wall of the multi-groove inner ear seat barrel cup is detachably connected to the base, the upper part of the lower rod piece is hingedly connected to the lower end of the upper push rod, the gear at the lower part of the lower rod piece is hingedly connected inside the multi-groove inner ear seat barrel cup, one end of the pressing plate is hingedly connected to the middle part inside the multi-groove inner ear seat barrel cup, the rack is slidingly connected to the inner wall of the multi-groove inner ear seat barrel cup, the teeth on the rack are engaged with the gears on the lower rod piece and the gears on the pressing plate, one side of the elastic sheet is fixedly connected to the lower surface of the pressing plate, and the ventilation protrusion is arranged on one side of the elastic sheet or the lower surface of the pressing plate. The application not only prevents tilting and saves energy, but also enables the waste pipette tip thrown each time to be immersed in disinfectant for complete disinfection in time, and the disinfectant and the waste pipette tip are separated for convenient operation.

The present solution provides a system and method for transround window membrane drug delivery. In summary, the system includes a micropump connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce a patient's round window membrane. The handpiece allows the cannula to be inserted into the round window membrane, improving distribution of the delivered drug throughout the inner ear. The present solution can function as a small, implantable or wearable device that can be used for chronic and acute transround window membrane drug delivery. This configuration allows the micropump to deliver small amounts of drug from an internal reservoir continuously or intermittently over a period of days to months.

The utility model discloses a bone conduction earphone loudspeaker structure, which comprises a conduction surface cover, a support, a vibrating reed, a voice coil, a PCB (printed circuit board), U iron, a washer and a magnet, the support is arranged at one end of the conduction surface cover, the support is provided with a cavity, the PCB, the voice coil, the washer, the magnet and the U iron are sequentially arranged on the cavity, the vibrating reed is a titanium vibrating reed, the vibrating reed is arranged between the conduction surface cover and the support, and the vibrating reed and the U iron are in contact positioning; thus, through the design that the vibrating reed is made of a metal material, and the vibrating reed is arranged between the bracket and the conduction surface cover, the structural firmness and the anti-falling effect of the bone conduction loudspeaker on the earphone are improved, and the stability when the bone conduction loudspeaker drives the earphone shell to vibrate so as to conduct sound waves to the inner ear is ensured; the sound conduction of the bone conduction earphone is clearer, so that the use experience of a user is improved, the usability is good, and the application range is wide.

The utility model provides a kind of medical handheld device and inner ear dosing device;The medical handheld device includes handheld shell and connector at one end of handheld shell;The connector has the through setting connector inner cavity, and handheld shell has the shell inner cavity being communicated with connector inner cavity;The connector is used for the detachable connection with the needle holder of puncture needle, and the connector inner cavity of connector is used for the sealed insertion of duct, so that, operator only needs to insert puncture needle into inner ear by medical handheld device, direct dosing of inner ear can be carried out, there is only one insertion operation in the whole process, effectively simplify operation process, improve operation convenience.

1. The name of the design product: hairpin (inner ear decorative panda). 2. The use of the design product: hairpin, doll. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: front view. 5. The design for which protection is sought includes color. 6. The bottom of the design product is not easily visible or invisible during use, and the top view is omitted.

The utility model discloses an earphone and an earphone system. The earphone comprises a shell, the shell comprises a sound output part and an ear clip part, the sound output part is provided with a containing cavity, the containing cavity is provided with a loudspeaker, a connecting sub-part of the ear clip part is connected between the sound output part and a hook-shaped sub-part of the ear clip part, at least part of the sound output part is located in an auricular conchae cavity of a user, and the ear clip part extends to the position between auricles and the head through an antihelix and a helix. The sound emitting surface of the sound emitting part and the outer surface of the hook-shaped sub-part are curved surfaces, and in a first projection plane where the width split of the hook-shaped sub-part is located, the tangent points of the common tangent of the projection of the sound emitting surface and the projection of the outer surface of the hook-shaped sub-part and the projection of the sound emitting surface and the projection of the outer surface of the hook-shaped sub-part are a first tangent point and a second tangent point respectively. An outer envelope line is projected on the shell, the outer envelope line comprises a first section and a second section which are connected, the first section extends to a second tangent point from a first tangent point in the first envelope direction, the second section extends to the second tangent point from the first tangent point in the second envelope direction, and the first section and the common tangent jointly define a first surface; the area of the first surface is greater than or equal to 300 mm and less than or equal to 1000 mm.

A pair of headphones that conduct sound using skin vibration and a method for wearing the same are disclosed. The headphones include a main body and a wearing structure. The main body includes a vibration generator and a skin contact portion. The vibration generator vibrates at least partially when powered on, and is assembled to the skin contact portion in a manner capable of transmitting its vibration to the skin contact portion. The wearing structure is connected to the main body and is adapted to be detachably placed on a user's ear, thereby allowing the main body to be worn on the user's ear. When the wearing structure is placed on the user's ear, the skin contact portion of the main body is in contact with the user's earlobe, so that when the skin contact portion vibrates, the vibration is transmitted to the skin of the earlobe and then to the user's inner ear, allowing the user to hear sound.

The invention discloses an HSP70-targeting chimeric antigen receptor-macrophage and application thereof in treatment of noise-induced hearing loss, an extracellular domain of the HSP70-targeting chimeric antigen receptor comprises an HSP70 specific binding fragment, an intracellular domain comprises an IL-4 signal channel functional element, a signal switch type CAR structure of the HSP70 is formed, and the macrophage can be used for treating noise-induced hearing loss, so that the HSP70-targeting chimeric antigen receptor-macrophage can be used for treating noise-induced hearing loss. The HSP70-targeted chimeric antigen receptor-macrophage can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage, is used for mediating polarization of the macrophage to an M2 type and exerting an anti-inflammatory function, is proved to be capable of specifically responding to an inner ear inflammation microenvironment, switching an anti-inflammatory phenotype and protecting hair cells and auditory nerves, can be used for treating noise-induced hearing loss, and can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage. The limitation that traditional hearing-aid equipment supports treatment on symptoms is broken through, and the hearing-aid device has a remarkable application prospect.

It is provided an equipment for treatment of a person, wherein the equipment is configured to achieve a target denture geometry characterized by a target denture plane (3), the target denture plane lying parallel to an internal ear line (11) through a left internal ear point (7) and a right internal ear point (9) of the person. Further, a manufacturing method is provided.

The invention belongs to the field of artificial vestibules, and discloses a bionic artificial vestibule device and method for passive energy collection and driving coupling of inner ear lost non-intrusive nerve regulation, and the device comprises a passive bionic vestibule sensor and a passive energy collection unit. The passive bionic vestibular sensor and the passive energy collection unit are both electrically connected with the control unit, the control unit is bidirectionally and electrically connected with the data storage unit for storing and calling data, the control unit is bidirectionally and electrically connected with the arithmetic unit, and the data in the data storage unit are processed according to the arithmetic unit. And the processing result is input to the second digital-to-analog conversion unit, the output end of the second digital-to-analog conversion unit is electrically connected with the input end of the nerve regulation and control energy driving unit, and the output end of the nerve regulation and control energy driving unit is electrically connected with the regulation and control energy delivery array. In combination with the real-time processing and self-adaptive control capability of the operation unit, a nerve regulation and control signal can be accurately generated, and core symptoms such as vibration magical vision and balance disorder can be effectively improved.

The embodiment of the invention provides a cell guiding device, and the device comprises a receiving coil which is used for receiving a radio frequency signal transmitted by an in-vitro energy supply device; the stimulator is electrically connected with the receiving coil and is used for generating an electrical stimulation pulse according to the radio frequency signal; the electrode array is used for being arranged in the cochlea and electrically connected with the stimulator; the electrode array is used for applying the electrical stimulation pulse to hair cells in the cochlea so as to stimulate the hair cells to proliferate and differentiate. According to the technical scheme provided by the embodiment of the invention, the electrical stimulation pulse is generated according to the in-vitro radio frequency signal and is applied to the hair cells in the cochlea, so that accurate and efficient electrical stimulation on the hair cells can be realized. Meanwhile, the implanted design is adopted to directly act on the hair cells in the cochlea, so that the trauma to the body can be reduced, and the safety and comfort of treatment are improved.

The utility model relates to the technical field of bird hearing perception system research, concretely relates to a bird brain stereoscopic positioning device, is applicable to small and medium size birds, including bottom plate, ear canal positioner, bill angle positioner and bill mouth positioner, the stand is set up on the bottom plate, the ear lever is fixed on the cross arm of stand, the ear canal positioner includes the left and right two parallel setting stands, left and right two ear levers, the stand is in the shape of " " the ear lever includes inner ear lever, outside sleeve lever, top cone and fastening screw, outside sleeve lever can along inner ear lever and carry out the translational sliding, and the position is fixed through fastening screw, the bill angle positioner includes side plate, bill lever and locking screw, the bill mouth positioner includes base, positioning stand, bill mouth positioning head, compression ring, the base can slide horizontally, the utility model has reduced the ear canal blockage and the phenomenon of weak support because of traditional embedded ear lever and single side bill lever, greatly improves the listening range and effect of bird hearing perception system to sound stimulation.

The present invention provides a technology for creating functional inner ear stria vascularis marginal cells that are potentially applicable for screening of chemical agents and pathological analysis of hearing impairment. This method for producing inner ear stria vascularis marginal cells comprises a step for culturing a cell population including inner ear precursor cells, in an insulin-free culture medium that does not contain insulin or contains insulin only in a trace amount.

The invention provides viral vectors on the basis of adeno-associated virus (AAV) for transducing cells with a nucleic acid construct contained in the viral vector for delivery of a nucleic acid construct by the viral vector, which in their capsid proteins contain an insert arranged at an integration site for a peptide insert in viral proteins which integration site is located on a protruding loop of VP1, VP2 and / or VP3. The insert provides the viral vectors with specificity for targeting inner ear cells, especially for delivery of nucleic acid constructs contained in the viral vectors to inner ear cells.

The invention discloses a method for establishing a rat bionic model for sudden deafness caused by inner ear microcirculation disturbance, and relates to the technical field of animal model construction.The method comprises the steps that exosome extraction and purification are conducted, specifically, healthy rat bone marrow is obtained, mesenchymal stem cells are extracted and placed in a culture bottle to be cultured, cell culture supernate is collected, and the exosome is obtained; extracting exosomes by adopting an ultracentrifugation method; loading of the procoagulant factor and the exosome: selecting a prothrombin fragment as the procoagulant factor, treating the prothrombin fragment, and mixing the obtained exosome resuspension and the prothrombin fragment solution according to the volume ratio of 1: 1. The exosome derived from the mesenchymal stem cells is adopted as a procoagulant factor carrier, the source is wide, and the exosome is easy to obtain; the exosome is stable in yield and good in biocompatibility, damage to inner ear tissues of rats can be reduced, and the exosome has natural targeting transportation capacity and can be specifically combined with inner ear vascular endothelial cells, so that the concentration of a procoagulant factor at a target site is increased, and the accuracy of model establishment is enhanced.

The utility model discloses an earphone and an earphone system. The earphone comprises a shell, the shell comprises a sound making part and an ear clip part, the sound making part is provided with a containing cavity, a loudspeaker is arranged in the containing cavity, the ear clip part comprises a connecting sub-part and a hook-shaped sub-part, the connecting sub-part is connected between the sound making part and the hook-shaped sub-part, and under the condition that a user wears the earphone, the sound making part is configured to be at least partially located in a conchae cavity of the user, and the hook-shaped sub-part is configured to be at least partially located in the conchae cavity of the user. The ear clip part extends to the position between the auricles and the head through the antihelix and the helix, the loudspeaker is provided with a sound emitting surface for sound waves to penetrate out, the sound emitting part is provided with a sound emitting hole, the sound emitting hole is used for sound emitted by the loudspeaker to penetrate out of the sound emitting part, the sound emitting surface faces the sound emitting surface, and the value range of the ratio of the closure area of the sound emitting hole to the area of the sound emitting surface is larger than or equal to 0.2. And less than or equal to 0.65.