127 results about "Inner ear" patented technology

The present disclosure provides preventing and / or treating hearing loss in an individual in need thereof comprising administering a composition comprising one or more viral vectors comprising a nucleic acid encoding COL18A1 protein, SPARC protein, and IGFBP2 protein. The present disclosure also provides method for preventing and / or treating hearing loss in an individual in need thereof comprising administering an effective amount of COL18A1, SPARC, and IGFBP2 proteins to the inner ear of the individual.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

A body supports a speaker and an ear cushion adjacent a proximal portion thereof. The ear cushion is sized to fit within an ear canal of a user for holding of the earbud in position and directing sound from the speaker into the ear of the user. A distal end of the body supports a turn wheel in a rotational fashion relative to the body. The turn wheel has frictional resistance to rotation relative to the body which is less than friction force between the ear cushion and the inner ear of the user, such that torque applied to the turn wheel causes the turn wheel to rotate relative to the body. Rotation of the turn wheel causes at least one characteristic of sound emanating from the speaker of the earbud to be modified. A charger box is also provided which can contain and wirelessly charge a pair of earbuds.

The system according to the embodiment aims to eliminate inconveniences in daily life caused by hearing impairments or hearing loss. According to an embodiment, the system includes a collection unit, an analysis unit, and a transmission unit. The collection unit collects ambient sound. The analysis unit analyzes the sound collected by the collection unit. The transmission unit transmits the sound analyzed by the analysis unit to the inner ear using bone conduction technology.

The application relates to a micro actuator for inner ear injection sampling surgery, and relates to the field of medical instruments.The application solves the problems that the existing actuator cannot more accurately assist the doctor in judging the surgery progress, lacks clinical surgery practicability in design, and makes the otological surgery still have certain operation difficulty.The microneedle puncture mechanism module is embedded in the driving and sensing module, the driving and sensing module is installed on the high-precision linear driving module, the end operation mechanism module is installed at the front of the driving and sensing module, the microneedle puncture mechanism module passes through the end operation mechanism module and extends out, and the endoscope camera module in the end operation mechanism module provides real-time images in the surgery process, the tension sensor in the driving and sensing module monitors the change of the steel wire tension in real time, and safety interaction with the ear canal environment is ensured.The application is used for inner ear injection sampling surgery.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The invention discloses a rotating steel bar damper of a four-connecting-rod structure. The rotating steel bar damper comprises an outer lug plate, an inner lug plate, an energy dissipation steel bar, a pin shaft and a sleeve. According to the rotating steel bar damper of the four-connecting-rod structure, the damper can deform in any direction in a plane, each pin shaft and the corresponding energy dissipation steel bar surrounding one circle of the pin shaft form a single rotating unit, under the earthquake effect, when the outer lug plate moves in a certain direction, the outer lug plate and the inner lug plate rotate relatively, and therefore the rotating steel bar damper can deform in any direction. The shearing force between the outer lug plate and the inner lug plate is borne by the pin shaft, the bending moment generated by relative rotation of the outer lug plate and the inner lug plate is borne by the energy dissipation steel bar, bending-shearing separation is achieved through the structure, overall plastic deformation of the damper is concentrated on the energy dissipation section of the energy dissipation steel bar, and earthquake energy is dissipated through shearing plastic deformation of the energy dissipation steel bar. And according to the damper, translation deformation is converted into rotation deformation through a four-connecting-rod structure, and the deformation capacity of the metal shearing type damper is improved.

This utility model discloses a low-noise centrifugal pump for petrochemical applications, comprising a centrifugal pump body, an impeller movably mounted inside the pump body with an impeller shaft mounted on it, an inlet pipe at the front of the pump body, a drain pipe at the top of the pump body, and a low-noise mechanism wrapped around the outside of the pump body. The low-noise mechanism consists of noise reduction covers A, B, C, and D. Noise reduction cover B is fixedly mounted at one end of noise reduction cover A, and noise reduction cover D is fixedly mounted at one end of noise reduction cover C. This low-noise centrifugal pump for petrochemical applications features modularly designed noise reduction covers that can be quickly installed using a mounting bracket without complex tools or specialized skills, reducing the noise level generated by the centrifugal pump and preventing damage to the inner ear hair cells of factory workers, thus avoiding irreversible hearing loss. The rock wool itself has a porous fiber structure, primarily absorbing mid-to-high frequency noise.

The application provides a press-immersion type waste pipette tip storage and disinfection container, which comprises a multi-groove inner ear seat barrel cup, a rack, an upper push rod, a lower rod piece, a pressing plate, an elastic sheet, a ventilation protrusion and a base, the lower part of the outer wall of the multi-groove inner ear seat barrel cup is detachably connected to the base, the upper part of the lower rod piece is hingedly connected to the lower end of the upper push rod, the gear at the lower part of the lower rod piece is hingedly connected inside the multi-groove inner ear seat barrel cup, one end of the pressing plate is hingedly connected to the middle part inside the multi-groove inner ear seat barrel cup, the rack is slidingly connected to the inner wall of the multi-groove inner ear seat barrel cup, the teeth on the rack are engaged with the gears on the lower rod piece and the gears on the pressing plate, one side of the elastic sheet is fixedly connected to the lower surface of the pressing plate, and the ventilation protrusion is arranged on one side of the elastic sheet or the lower surface of the pressing plate. The application not only prevents tilting and saves energy, but also enables the waste pipette tip thrown each time to be immersed in disinfectant for complete disinfection in time, and the disinfectant and the waste pipette tip are separated for convenient operation.

The present solution provides a system and method for transround window membrane drug delivery. In summary, the system includes a micropump connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce a patient's round window membrane. The handpiece allows the cannula to be inserted into the round window membrane, improving distribution of the delivered drug throughout the inner ear. The present solution can function as a small, implantable or wearable device that can be used for chronic and acute transround window membrane drug delivery. This configuration allows the micropump to deliver small amounts of drug from an internal reservoir continuously or intermittently over a period of days to months.

The utility model provides a kind of medical handheld device and inner ear dosing device;The medical handheld device includes handheld shell and connector at one end of handheld shell;The connector has the through setting connector inner cavity, and handheld shell has the shell inner cavity being communicated with connector inner cavity;The connector is used for the detachable connection with the needle holder of puncture needle, and the connector inner cavity of connector is used for the sealed insertion of duct, so that, operator only needs to insert puncture needle into inner ear by medical handheld device, direct dosing of inner ear can be carried out, there is only one insertion operation in the whole process, effectively simplify operation process, improve operation convenience.

1. The name of the design product: hairpin (inner ear decorative panda). 2. The use of the design product: hairpin, doll. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: front view. 5. The design for which protection is sought includes color. 6. The bottom of the design product is not easily visible or invisible during use, and the top view is omitted.

The utility model discloses an earphone and an earphone system. The earphone comprises a shell, the shell comprises a sound output part and an ear clip part, the sound output part is provided with a containing cavity, the containing cavity is provided with a loudspeaker, a connecting sub-part of the ear clip part is connected between the sound output part and a hook-shaped sub-part of the ear clip part, at least part of the sound output part is located in an auricular conchae cavity of a user, and the ear clip part extends to the position between auricles and the head through an antihelix and a helix. The sound emitting surface of the sound emitting part and the outer surface of the hook-shaped sub-part are curved surfaces, and in a first projection plane where the width split of the hook-shaped sub-part is located, the tangent points of the common tangent of the projection of the sound emitting surface and the projection of the outer surface of the hook-shaped sub-part and the projection of the sound emitting surface and the projection of the outer surface of the hook-shaped sub-part are a first tangent point and a second tangent point respectively. An outer envelope line is projected on the shell, the outer envelope line comprises a first section and a second section which are connected, the first section extends to a second tangent point from a first tangent point in the first envelope direction, the second section extends to the second tangent point from the first tangent point in the second envelope direction, and the first section and the common tangent jointly define a first surface; the area of the first surface is greater than or equal to 300 mm and less than or equal to 1000 mm.

A pair of headphones that conduct sound using skin vibration and a method for wearing the same are disclosed. The headphones include a main body and a wearing structure. The main body includes a vibration generator and a skin contact portion. The vibration generator vibrates at least partially when powered on, and is assembled to the skin contact portion in a manner capable of transmitting its vibration to the skin contact portion. The wearing structure is connected to the main body and is adapted to be detachably placed on a user's ear, thereby allowing the main body to be worn on the user's ear. When the wearing structure is placed on the user's ear, the skin contact portion of the main body is in contact with the user's earlobe, so that when the skin contact portion vibrates, the vibration is transmitted to the skin of the earlobe and then to the user's inner ear, allowing the user to hear sound.

The invention discloses an HSP70-targeting chimeric antigen receptor-macrophage and application thereof in treatment of noise-induced hearing loss, an extracellular domain of the HSP70-targeting chimeric antigen receptor comprises an HSP70 specific binding fragment, an intracellular domain comprises an IL-4 signal channel functional element, a signal switch type CAR structure of the HSP70 is formed, and the macrophage can be used for treating noise-induced hearing loss, so that the HSP70-targeting chimeric antigen receptor-macrophage can be used for treating noise-induced hearing loss. The HSP70-targeted chimeric antigen receptor-macrophage can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage, is used for mediating polarization of the macrophage to an M2 type and exerting an anti-inflammatory function, is proved to be capable of specifically responding to an inner ear inflammation microenvironment, switching an anti-inflammatory phenotype and protecting hair cells and auditory nerves, can be used for treating noise-induced hearing loss, and can be used for preparing the HSP70-targeted chimeric antigen receptor-macrophage. The limitation that traditional hearing-aid equipment supports treatment on symptoms is broken through, and the hearing-aid device has a remarkable application prospect.

The invention belongs to the field of artificial vestibules, and discloses a bionic artificial vestibule device and method for passive energy collection and driving coupling of inner ear lost non-intrusive nerve regulation, and the device comprises a passive bionic vestibule sensor and a passive energy collection unit. The passive bionic vestibular sensor and the passive energy collection unit are both electrically connected with the control unit, the control unit is bidirectionally and electrically connected with the data storage unit for storing and calling data, the control unit is bidirectionally and electrically connected with the arithmetic unit, and the data in the data storage unit are processed according to the arithmetic unit. And the processing result is input to the second digital-to-analog conversion unit, the output end of the second digital-to-analog conversion unit is electrically connected with the input end of the nerve regulation and control energy driving unit, and the output end of the nerve regulation and control energy driving unit is electrically connected with the regulation and control energy delivery array. In combination with the real-time processing and self-adaptive control capability of the operation unit, a nerve regulation and control signal can be accurately generated, and core symptoms such as vibration magical vision and balance disorder can be effectively improved.

The embodiment of the invention provides a cell guiding device, and the device comprises a receiving coil which is used for receiving a radio frequency signal transmitted by an in-vitro energy supply device; the stimulator is electrically connected with the receiving coil and is used for generating an electrical stimulation pulse according to the radio frequency signal; the electrode array is used for being arranged in the cochlea and electrically connected with the stimulator; the electrode array is used for applying the electrical stimulation pulse to hair cells in the cochlea so as to stimulate the hair cells to proliferate and differentiate. According to the technical scheme provided by the embodiment of the invention, the electrical stimulation pulse is generated according to the in-vitro radio frequency signal and is applied to the hair cells in the cochlea, so that accurate and efficient electrical stimulation on the hair cells can be realized. Meanwhile, the implanted design is adopted to directly act on the hair cells in the cochlea, so that the trauma to the body can be reduced, and the safety and comfort of treatment are improved.

The utility model relates to the technical field of bird hearing perception system research, concretely relates to a bird brain stereoscopic positioning device, is applicable to small and medium size birds, including bottom plate, ear canal positioner, bill angle positioner and bill mouth positioner, the stand is set up on the bottom plate, the ear lever is fixed on the cross arm of stand, the ear canal positioner includes the left and right two parallel setting stands, left and right two ear levers, the stand is in the shape of " " the ear lever includes inner ear lever, outside sleeve lever, top cone and fastening screw, outside sleeve lever can along inner ear lever and carry out the translational sliding, and the position is fixed through fastening screw, the bill angle positioner includes side plate, bill lever and locking screw, the bill mouth positioner includes base, positioning stand, bill mouth positioning head, compression ring, the base can slide horizontally, the utility model has reduced the ear canal blockage and the phenomenon of weak support because of traditional embedded ear lever and single side bill lever, greatly improves the listening range and effect of bird hearing perception system to sound stimulation.

The present invention provides a technology for creating functional inner ear stria vascularis marginal cells that are potentially applicable for screening of chemical agents and pathological analysis of hearing impairment. This method for producing inner ear stria vascularis marginal cells comprises a step for culturing a cell population including inner ear precursor cells, in an insulin-free culture medium that does not contain insulin or contains insulin only in a trace amount.

The invention provides viral vectors on the basis of adeno-associated virus (AAV) for transducing cells with a nucleic acid construct contained in the viral vector for delivery of a nucleic acid construct by the viral vector, which in their capsid proteins contain an insert arranged at an integration site for a peptide insert in viral proteins which integration site is located on a protruding loop of VP1, VP2 and / or VP3. The insert provides the viral vectors with specificity for targeting inner ear cells, especially for delivery of nucleic acid constructs contained in the viral vectors to inner ear cells.

The invention discloses a method for establishing a rat bionic model for sudden deafness caused by inner ear microcirculation disturbance, and relates to the technical field of animal model construction.The method comprises the steps that exosome extraction and purification are conducted, specifically, healthy rat bone marrow is obtained, mesenchymal stem cells are extracted and placed in a culture bottle to be cultured, cell culture supernate is collected, and the exosome is obtained; extracting exosomes by adopting an ultracentrifugation method; loading of the procoagulant factor and the exosome: selecting a prothrombin fragment as the procoagulant factor, treating the prothrombin fragment, and mixing the obtained exosome resuspension and the prothrombin fragment solution according to the volume ratio of 1: 1. The exosome derived from the mesenchymal stem cells is adopted as a procoagulant factor carrier, the source is wide, and the exosome is easy to obtain; the exosome is stable in yield and good in biocompatibility, damage to inner ear tissues of rats can be reduced, and the exosome has natural targeting transportation capacity and can be specifically combined with inner ear vascular endothelial cells, so that the concentration of a procoagulant factor at a target site is increased, and the accuracy of model establishment is enhanced.

The utility model discloses an earphone and an earphone system. The earphone comprises a shell, the shell comprises a sound making part and an ear clip part, the sound making part is provided with a containing cavity, a loudspeaker is arranged in the containing cavity, the ear clip part comprises a connecting sub-part and a hook-shaped sub-part, the connecting sub-part is connected between the sound making part and the hook-shaped sub-part, and under the condition that a user wears the earphone, the sound making part is configured to be at least partially located in a conchae cavity of the user, and the hook-shaped sub-part is configured to be at least partially located in the conchae cavity of the user. The ear clip part extends to the position between the auricles and the head through the antihelix and the helix, the loudspeaker is provided with a sound emitting surface for sound waves to penetrate out, the sound emitting part is provided with a sound emitting hole, the sound emitting hole is used for sound emitted by the loudspeaker to penetrate out of the sound emitting part, the sound emitting surface faces the sound emitting surface, and the value range of the ratio of the closure area of the sound emitting hole to the area of the sound emitting surface is larger than or equal to 0.2. And less than or equal to 0.65.

The utility model relates to the technical field of medical instruments, and provides an ossicular prosthesis for tympanic sclerosis, comprising: an abutting disc for abutting against the tympanic membrane of a patient; one end of the connecting column is connected with the abutting disc, the other end of the connecting column is provided with a safety limiting piece, the end, away from the abutting disc, of the connecting column is used for being inserted into the inner ear vestibule of the patient, and the safety limiting piece is used for limiting the depth of the portion, inserted into the inner ear vestibule of the patient, of the connecting column; wherein the connecting column is provided with at least one winding ring, and the winding ring is used for adjusting the length of the connecting column. In the process of installing the ossicular prosthesis, when the connecting column needs to be lengthened, a doctor can clamp the winding ring through a clamp so that the two ends of the connecting column can be lengthened; when the connecting column needs to be shortened, a doctor can expand the winding ring with a tool to shorten the two ends of the winding ring. Therefore, the technical effect of quickly and conveniently adjusting the length of the connecting column is achieved. The ossicular prosthesis is more adaptive to the in-ear environment of a patient, and the operation efficiency of a doctor is improved.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

The invention relates to the technical field of nano medicines, and discloses an ATP / cerium coordination polymer nano regulator as well as a preparation method and application thereof. The invention relates to an ATP / cerium coordination polymer nano regulator. The invention relates to a self-assembly hydrogel which is prepared from raw materials including cerous nitrate (III), adenosine-5 '-disodium triphosphate, phospholipid polyethylene glycol amino, SS31 peptide and a diselenide cross-linking agent through a self-assembly and cross-linking method, can effectively remove ROS (reactive oxygen species) in an inner ear and protect cells from oxidative stress injury, thereby protecting auditory cells and improving the quality of the inner ear. The traditional Chinese medicine composition has the effect of treating hearing loss caused by oxidative stress induced by noise, can be used for treating hearing loss through middle ear cavity local administration, is simple in preparation method and mild in reaction condition, and can realize large-scale production. Cascade catalysis of cerium (III) and cerium (IV), ATP (adenosine triphosphate) energy supply and a nano system of a selenium biological material are utilized, and a novel method is provided for treating noise-induced hearing loss.

The invention discloses an earphone which comprises a sound production part, an abutting part and an ear hook, the ear hook is connected with the sound production part and the abutting part, in a wearing state, the sound production part and the abutting part form a clamping state on the two sides of a helix, and the sound production part is located in an auricular conchae cavity; the abutting part comprises a first shell and a first sound inlet hole formed in the first shell; the sound production part comprises a second shell and a second sound inlet hole formed in the second shell, the second shell is further provided with a sound outlet hole, and the sound outlet hole is provided with a first sound outlet end located on the outer wall face of the second shell; the ear hook is provided with a symmetry plane arranged in the length direction of the ear hook, the interior of the symmetry plane, the ear hook, the sound production part and the abutting part are provided with inner contours, and on the symmetry plane, the outer wall face of the second shell is provided with a third reference point closest to the abutting part. A fourth reference point farthest from the third reference point is arranged in the area, close to the edge of the helix, of the inner contour of the ear hook in the wearing state, a fifth reference point farthest from the fourth reference point is further arranged on the outer wall face of the second shell, and the first sound outlet end and the sound inlet end of the second sound inlet hole are located on the two sides of the fifth reference point. Through the above mode, the possibility that sound transmitted from the first sound outlet end is guided in by the second sound inlet hole is reduced, and the sound receiving effect of the earphone is improved.

The invention discloses a hearing health prompting device and a related device. The method comprises the following steps: acquiring in-ear audio data through an in-ear microphone of a first earphone; displaying the first progress information of the noise exposure in the first period on the volume bar; the first progress information is determined based on the audio data within the ear within the first period. Therefore, the real-time progress information of the noise exposure is displayed to the user on the volume bar to prompt the user to pay attention to the risk of the noise exposure to hearing health, so that the user can conveniently turn down the volume of the earphone or reduce the wearing time of the earphone in time, thereby avoiding hearing impairment.

The present application relates to a composition using an endothelin B receptor agonist, such as Sovastatin (N-succinyl-[Glu9, Ala11, 15] endothelin 1, IRL-1620), for promoting cell proliferation and protecting the original neuroepithelium of cochlear and vestibular cells located within the ear sac. The pharmaceutical composition is systemically administered by means of tympanic membrane puncture, cochleostomy or intravenous or intramuscular injection. A pharmaceutical composition for the treatment of sensorineural hearing loss and vestibular disorders caused by inner ear cell degeneration, the pharmaceutical composition comprising a compound of an endothelin analogue, the use being treated by the neuroprotection and neurogenesis mechanism of cochlear vestibular hair cells and synapses.

The utility model provides a kind of ear temperature gun shell for children, comprising: telephone toy shell, the inside of telephone toy shell is provided with the accommodating cavity compatible with ear temperature gun, telephone toy shell is reserved hole at the gun head of ear temperature gun, telephone toy shell is reserved operation area at the display screen and switch of ear temperature gun.Corresponding ear temperature gun is put into the accommodating cavity in telephone toy shell when children patient needs to use ear temperature gun, the gun head of ear temperature gun is stretched out from the hole of telephone toy shell, the telephone toy shell is child toy telephone shape, when the ear of child is measured, the joy of ear temperature detection of child is improved, and the acceptance of child is higher, effectively alleviate the fear of ear temperature detection of child, reduce the crying mood of child, can help medical staff to carry out ear temperature detection to child faster, improve the efficiency of ear temperature, simultaneously, telephone toy shell plays certain protective effect to ear temperature gun.

The utility model discloses a transduction assembly, an earphone and an earphone system. The transduction assembly comprises a shell, an active vibration assembly and a passive vibration assembly. The shell comprises a contact area and a non-contact area which are in contact with the ear part and is provided with an accommodating cavity, the contact area is provided with a sound outlet hole, and the non-contact area is provided with a mounting hole. The active vibration assembly is contained in the containing cavity and used for generating a first sound wave through vibration, at least part of the first sound wave is output from the sound outlet hole, part of the first sound wave output from the sound outlet hole is transmitted to the inner ear through the ear canal, and the other part of the first sound wave is transmitted to the environment. The passive vibration assembly is mounted in the mounting hole, the passive vibration assembly vibrates under the action of vibration of the active vibration assembly to generate second sound waves, and the second sound waves are used for counteracting the first sound waves in the environment.